TANK

Summary

Gene Symbol: TANK
Description: TRAF family member associated NFKB activator
Alias: I-TRAF, ITRAF, TRAF2, TRAF family member-associated NF-kappa-B activator, TRAF-interacting protein
Species: human

Top Publications

  1. pmc The scaffold protein TANK/I-TRAF inhibits NF-kappaB activation by recruiting polo-like kinase 1
    Wanqiao Zhang
    State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, China
    Mol Biol Cell 21:2500-13. 2010
  2. ncbi Induction of IRF-3 and IRF-7 phosphorylation following activation of the RIG-I pathway
    S Paz
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, 3755 Cote Ste Catherine, Montreal, Quebec, Canada H3T 1E2
    Cell Mol Biol (Noisy-le-grand) 52:17-28. 2006
  3. pmc Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming protein
    K M Kaye
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Proc Natl Acad Sci U S A 93:11085-90. 1996
  4. pmc NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase
    J L Pomerantz
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    EMBO J 18:6694-704. 1999
  5. ncbi Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK
    Beichu Guo
    Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California 90095, USA
    J Biol Chem 282:11817-26. 2007
  6. pmc SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK
    Grigory Ryzhakov
    Medical Research Council Laboratory of Molecular Biology, Cambridge, UK
    EMBO J 26:3180-90. 2007
  7. ncbi Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF
    Jean Stéphane Gatot
    Interdisciplinary Cluster for Applied Genoproteomics, Medical Chemistry, and Virology Immunology units, University of Liege, Sart Tilman, 4000 Liege, Belgium
    J Biol Chem 282:31131-46. 2007
  8. pmc I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction
    M Rothe
    Tularik, Inc, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 93:8241-6. 1996
  9. ncbi NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation
    F Nomura
    Department of Host Defense, Core Research for Evolutional Science and Technology of Japan Science and Technology Corporation, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Genes Cells 5:191-202. 2000
  10. ncbi Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases
    Alain Chariot
    Laboratory of Immunoregulation, NIAID, National Institutes of Health, Bethesda, Maryland 20892 1876, USA
    J Biol Chem 277:37029-36. 2002

Research Grants

  1. Development of an Acoustic Biological Shaker
    TODD MCADAMS; Fiscal Year: 2005
  2. Multi-component In Situ Chemical Analyzer for Cell Culture Processes
    RONALD MICHEELS; Fiscal Year: 2007
  3. ENHANCED ROLLER BOTTLE
    John Wilson; Fiscal Year: 2003
  4. Negative regulation of NF-kB and inflammation by TAX1BP1
    Edward W Harhaj; Fiscal Year: 2012
  5. GAMMA DELTA T CELLS IN LYME ARTHRITIS
    Ralph C Budd; Fiscal Year: 2011
  6. Heat Shock-Induced Apoptosis
    Shawn B Bratton; Fiscal Year: 2012
  7. DOUGLAS LOWELL MANN; Fiscal Year: 2016
  8. Cytoprotective cytokine signaling and reperfusion injury
    DOUGLAS LOWELL MANN; Fiscal Year: 2010
  9. BTK SIGNALING IN B CELL SURVIVAL BY BAFF-R
    Wasif N Khan; Fiscal Year: 2011
  10. The role of MCPIP1 in regulating NF-kB signaling and macrophage activation
    Mingui Fu; Fiscal Year: 2012

Detail Information

Publications566 found, 100 shown here

  1. pmc The scaffold protein TANK/I-TRAF inhibits NF-kappaB activation by recruiting polo-like kinase 1
    Wanqiao Zhang
    State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, China
    Mol Biol Cell 21:2500-13. 2010
    b>TANK/I-TRAF is a TRAF-binding protein that negatively regulates NF-kappaB activation. The underlying mechanism of this activity remains unclear. Here we show that TANK directly interacts with PLK1, a conserved cell cycle-regulated kinase...
  2. ncbi Induction of IRF-3 and IRF-7 phosphorylation following activation of the RIG-I pathway
    S Paz
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, 3755 Cote Ste Catherine, Montreal, Quebec, Canada H3T 1E2
    Cell Mol Biol (Noisy-le-grand) 52:17-28. 2006
    ..These studies link RIG-I sensing of viral RNA to downstream kinase signaling and phosphorylation of IRF-3 and IRF-7 via the MAVS/IPS/VISA/Cardif adaptor...
  3. pmc Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming protein
    K M Kaye
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Proc Natl Acad Sci U S A 93:11085-90. 1996
    ..A TRAF interacting protein, TANK, inhibits NF-kappa B activation by more than 70% from both LMP1 CT domains...
  4. pmc NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase
    J L Pomerantz
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    EMBO J 18:6694-704. 1999
    ..TBK1, TANK and TRAF2 can form a ternary complex, and complex formation appears to be required for TBK1 activity...
  5. ncbi Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK
    Beichu Guo
    Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California 90095, USA
    J Biol Chem 282:11817-26. 2007
    ..that the TRAF (tumor necrosis factor receptor-associated factor) family member-associated NF-kappaB activator (TANK) plays an important role in interferon induction through both retinoic acid-inducible gene I- and Toll-like ..
  6. pmc SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK
    Grigory Ryzhakov
    Medical Research Council Laboratory of Molecular Biology, Cambridge, UK
    EMBO J 26:3180-90. 2007
    ..Activation of IRF3 requires its phosphorylation by TBK1 (TANK-binding kinase) or IKKi (inhibitor of nuclear factor kappaB kinase, inducible)...
  7. ncbi Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF
    Jean Stéphane Gatot
    Interdisciplinary Cluster for Applied Genoproteomics, Medical Chemistry, and Virology Immunology units, University of Liege, Sart Tilman, 4000 Liege, Belgium
    J Biol Chem 282:31131-46. 2007
    ..The scaffold proteins that assemble these kinase complexes are poorly characterized. We show here that TANK/ITRAF is required for the TBK1- and IKKepsilon-mediated IRF3/7 phosphorylations through some Toll-like receptor-..
  8. pmc I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction
    M Rothe
    Tularik, Inc, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 93:8241-6. 1996
    ..b>TRAF2 is required for CD40- and TNF-mediated activation of the transcription factor NF-kappa B...
  9. ncbi NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation
    F Nomura
    Department of Host Defense, Core Research for Evolutional Science and Technology of Japan Science and Technology Corporation, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Genes Cells 5:191-202. 2000
    ..Unlike IKK-alpha and IKK-beta, IKK-i phosphorylated Ser36 but not Ser32 in vitro, suggesting that IKK-i activates NF-kappaB by distinct mechanisms from the conventional IKKs...
  10. ncbi Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases
    Alain Chariot
    Laboratory of Immunoregulation, NIAID, National Institutes of Health, Bethesda, Maryland 20892 1876, USA
    J Biol Chem 277:37029-36. 2002
    ..Here we identify TANK (TRAF family member-associated NF-kappa B activator) as a NEMO/IKK gamma-interacting protein via yeast two-hybrid ..
  11. pmc TNFalpha- and IKKbeta-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKKgamma and NF-kappaB activation
    Marianne Bonif
    Laboratory of Medical Chemistry and Human Genetics, Center for Biomedical Integrated Genoproteomics, University of Liege, Sart Tilman, B 4000 Liege, Belgium
    Biochem J 394:593-603. 2006
    ..Here, we show that the pro-inflammatory cytokine TNFalpha (tumour necrosis factor alpha) promotes TANK [TRAF (TNF receptor-associated factor) family member associated NF-kappaB activator] recruitment to the IKK complex ..
  12. doi Association of a TANK gene polymorphism with outcomes of hepatitis B virus infection in a Chinese Han population
    Qi Long Song
    Institute of Liver Diseases, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Viral Immunol 25:73-8. 2012
    ..tumor necrosis factor receptor-associated factor family member-associated nuclear factor-κB (NF-κB) activator (TANK) takes part in the tumor necrosis factor-α (TNF-α)-mediated NF-κB signaling pathway and the interferon (IFN)-..
  13. ncbi [Characteristics of enterotoxigenic Escherichia coli and E. coli harboring enteroaggregative E. coli heat-stable enterotoxin-1 (EAST-1) gene isolated from a water-borne outbreak]
    J Yatsuyanagi
    Akita Prefectural Institute of Public Health, Japan
    Kansenshogaku Zasshi 70:215-23. 1996
    ..enterotoxin-1 (EAST-1) gene were isolated from 5 of 13 patient's feces and 1 feces sample obtained from the septic tank. Both of the E...
  14. ncbi [Central nervous system infection by free-living amebas: report of 3 Venezuelan cases]
    R Rodriguez
    Facultad de Medicina, Universidad del Zulia, Venezuela
    Rev Neurol 26:1005-8. 1998
    ..The disease becomes evident in two different clinical fashions: Primary Amebic Meningoencephalitis (PAM) caused by Naegleria fowleri and Granulomatous Amebic Encephalitis (GAE) induced by Spp. of Acanthamoeba and Balamuthia...
  15. ncbi Affinity chromatography of human estrogen receptor-alpha expressed in Saccharomyces cerevisiae. Combination of heparin- and 17beta-estradiol-affinity chromatography
    W Feng
    Institute for Applied Microbiology, University of Agricultural Sciences, Vienna, Austria
    J Chromatogr A 852:161-73. 1999
    ..J. Steroid Biochem. Mol. Biol. 57 (1996) 293] in a 14 l stirred tank reactor. The yeast extract contained 2-4 pmol of receptor protein per mg total protein...
  16. doi Biodegradation of international jet A-1 aviation fuel by microorganisms isolated from aircraft tank and joint hydrant storage systems
    A Y Itah
    University of Uyo, Uyo, Nigeria
    Bull Environ Contam Toxicol 83:318-27. 2009
    Microorganisms contaminating international Jet A-1 aircraft fuel and fuel preserved in Joint Hydrant Storage Tank (JHST) were isolated, characterized and identified...
  17. ncbi Orientation of Aplysia californica to distant food sources
    T Teyke
    Center for Neurobiology and Behavior, New York State Psychiatric Institute, NY
    J Comp Physiol A 170:281-9. 1992
    ..In a small, open field tank with still water, the animals took an average of 42 min to find a piece of seaweed, even though the stimulus was ..
  18. ncbi Profiles of alpha-melanocyte-stimulating hormone in the Japanese flounder as revealed by a newly developed time-resolved fluoroimmunoassay and immunohistochemistry
    Noriko Amiya
    School of Fisheries Sciences, Kitasato University, Ofunato, Iwate 022 0101, Japan
    Gen Comp Endocrinol 151:135-41. 2007
    ..newly developed, and its levels in the pituitary gland and plasma of Japanese flounder reared in a white or black tank for 5 months were compared...
  19. ncbi CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization
    S S Pullen
    Department of Biology, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut 06877 0368, USA
    Biochemistry 37:11836-45. 1998
    ..TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain...
  20. ncbi Clarification of Muscat musts using wheat proteins and the flotation technique
    Richard Marchal
    Laboratoire d Oenologie, Universite de Reims, URVVC, B P 1039, 51687 Reims Cedex 2, France
    J Agric Food Chem 51:2040-8. 2003
    ..Clairette de Die (French-controlled appellation) is a sparkling sweet wine. The alcoholic fermentation begins in a tank, continues in a crown-cap bottle, and stops before the complete consumption of sugar...
  21. ncbi Sensory evoked potentials in unanesthetized unrestrained cuttlefish: a new preparation for brain physiology in cephalopods
    T H Bullock
    Neurobiology Unit, Scripps Institution of Oceanography, University of California, San Diego, La Jolla
    J Comp Physiol A 168:141-50. 1991
    ..The Lower Fusion Frequency of averaged responses is less than 30/s. Gentle tapping of the tank wall evokes local, brief, fast potentials...
  22. ncbi Sodium sensitive and sodium retaining hypertension
    G Kimura
    Department of Medicine, National Cardiovascular Center, Osaka, Japan
    Am J Hypertens 3:854-8. 1990
    ..differences between sodium sensitive and sodium retaining hypertension were theoretically considered using a water tank model of body fluid volume-blood pressure regulation...
  23. ncbi Minimizing the level of Bacillus cereus spores in farm tank milk
    M M M Vissers
    Department of Health and Safety, NIZO Food Research, PO Box 20, 6710 BA Ede, The Netherlands
    J Dairy Sci 90:3286-93. 2007
    In a year-long survey on 24 Dutch farms, Bacillus cereus spore concentrations were measured in farm tank milk (FTM), feces, bedding material, mixed grass and corn silage, and soil from the pasture...
  24. ncbi Antimicrobial treatment of fish tank granuloma
    R B Laing
    Regional Infectious Diseases Unit, City Hospital, Edinburgh, UK
    J Hand Surg Br 22:135-7. 1997
    Three patients with fish tank granuloma of the hand and forearm are reported. Each patient was treated with antimicrobial regimes which have rarely or never been previously used in this condition...
  25. ncbi [Increase in the colony count in drinking water tanks caused by solvents from the coating material]
    K Frensch

    Zentralbl Bakteriol Mikrobiol Hyg B 184:556-9. 1987
    As a freshly coated storage tank was put into operation a permanent colony increase in the drinking water (up to 7400 cfu/ml) could be detected. By chlorine dosage (30 mg/l) colony counts were reduced...
  26. ncbi Paradoxical sleep deprivation increases the content of glutamate and glutamine in rat cerebral cortex
    L Bettendorff
    Laboratory of Neurochemistry, , Belgium
    Sleep 19:65-71. 1996
    ..No significant nycthemeral variations in amino acid levels could be detected. PSD (12-24 hours), using the water tank method, significantly increased the levels of glutamate and glutamine...
  27. ncbi Prevalence of foodborne pathogens in bulk tank milk
    B M Jayarao
    Minnesota South Dakota Dairy Food Research Center, Department of Dairy Science, South Dakota State University, Brookings 57007 0647, USA
    J Dairy Sci 84:2157-62. 2001
    Bulk tank milk from 131 dairy herds in eastern South Dakota and western Minnesota was examined for the presence of for foodborne pathogens...
  28. ncbi Percutaneous transtracheal ventilation: resuscitation bags do not provide adequate ventilation
    Edmond A Hooker
    Department of Health Services Administration, Xavier University, Cincinnati, OH 45207 7331, USA
    Prehosp Disaster Med 21:431-5. 2006
    ..Percutaneous, transtracheal jet ventilation (PTJV) is an effective way to ventilate both adults and children. However, some authors suggest that a resuscitation bag can be utilized to ventilate through a cannula placed into the trachea...
  29. pmc Buspirone, chlordiazepoxide and diazepam effects in a zebrafish model of anxiety
    Zachary Bencan
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, 340 Bell Building, Box 3412, Durham, NC 27710, USA
    Pharmacol Biochem Behav 94:75-80. 2009
    ..In a novel tank, zebrafish dwell in the bottom of the tank initially and then increase their swimming exploration to higher levels ..
  30. ncbi Rheology of a dilute suspension of liquid-filled elastic capsules
    Prosenjit Bagchi
    Department of Mechanical and Aerospace Engineering, Rutgers University, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 81:056320. 2010
    ..when the vesicles undergo an unsteady vacillating-breathing dynamics at the threshold of a transition between the tank-treading and tumbling motions...
  31. ncbi Characterization of Campylobacter jejuni and Campylobacter coli isolated from waste water
    W Stelzer
    , Bad Elster, GDR
    Zentralbl Bakteriol Mikrobiol Hyg A 269:188-96. 1988
    ..No reduction of the indicator bacteria was found in the activated sludge tank, there was, however, a significant reduction (94.5%) of campylobacters...
  32. ncbi Plasticity of the electric organ discharge waveform of male Brachyhypopomus pinnicaudatus. II. Social effects
    C R Franchina
    Department of Biological Sciences, Florida International University, Miami 33199, USA
    J Comp Physiol A 187:45-52. 2001
    ..Introduction of a second fish to the experimental tank restored electric organ discharge duration and amplitude...
  33. ncbi Haptoglobin and serum amyloid A in relation to the somatic cell count in quarter, cow composite and bulk tank milk samples
    Maria Akerstedt
    Department of Food Science, Swedish University of Agricultural Sciences, SE 750 07 Uppsala, Sweden
    J Dairy Res 74:198-203. 2007
    ..The aim of this study was to investigate relationships between Hp, SAA and SCC in quarter, cow composite, and bulk tank milk samples...
  34. ncbi Minimizing the level of butyric acid bacteria spores in farm tank milk
    M M M Vissers
    Department of Health and Safety, NIZO Food Research, PO Box 20, 6710 BA Ede, The Netherlands
    J Dairy Sci 90:3278-85. 2007
    ..to determine the effects of farm management on the concentrations of butyric acid bacteria (BAB) spores in farm tank milk (FTM). The results were used to validate a control strategy derived from model simulations...
  35. ncbi Effect of feeding fermented liquid feed and fermented grain on gastrointestinal ecology and growth performance in piglets
    N Canibe
    University of Aarhus, Faculty of Agricultural Sciences, Department of Animal Health, Welfare and Nutrition, Denmark
    J Anim Sci 85:2959-71. 2007
    ..The FLG diet was prepared by storing the dietary cereals (barley and wheat) and water (1:2.5, wt/wt) in a closed tank at 20 degrees C and adding the remaining dietary ingredients immediately before feeding...
  36. doi Spray droplet size, drift potential, and risks to nontarget organisms from aerially applied glyphosate for coca control in Colombia
    Andrew J Hewitt
    The University of Queensland, Centre for Pesticide Application and Safety, Gatton, Australia
    J Toxicol Environ Health A 72:921-9. 2009
    ..The droplet size spectra for tank mixes containing glyphosate and Cosmo-Flux were considerably finer than water and became finer with higher aircraft ..
  37. ncbi Modeling and measuring lateral line excitation patterns to changing dipole source locations
    S Coombs
    Parmly Hearing Institute, Loyola University of Chicago, IL 60626, USA
    J Comp Physiol A 178:359-71. 1996
    ..to pressure distributions measured for the same dipole source with a miniature hydrophone placed in a small test tank used for neurophysiological experiments...
  38. ncbi TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation
    Liusheng He
    Flow Cytometry Section in the Office of Science and Technology, National Institute of Arthritis and Musculoskeletal and Skin Diseases NIH, 9000 Rockville Pike, Building 10, Bethesda, MD 20892, USA
    J Biol Chem 279:55855-65. 2004
    ..of HeLa cells with plasmids expressing CFP- or YFP-TRAF fusion proteins, constitutive homotypic association of TRAF2, -3, and -5 was observed, as well as heterotypic association of TRAF1-TRAF2 and TRAF3-TRAF5...
  39. ncbi [The behavior of polychlorinated biphenyls (PCB) in water purification plants. I. Mathematical balancing in a model purification plant]
    M Emmrich

    Zentralbl Bakteriol Mikrobiol Hyg B 186:205-19. 1988
    ..Because there is no loss of PCB through the ventilation of the activated sludge tank and according to the isomeric mass balance, it can be concluded that the less chlorinated PCB are decomposed ..
  40. pmc Allosteric regulation of the ubiquitin:NIK and ubiquitin:TRAF3 E3 ligases by the lymphotoxin-beta receptor
    Hideki Sanjo
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA
    J Biol Chem 285:17148-55. 2010
    ..in unstimulated cells by the ubiquitin:NIK E3 ligase comprised of subunits TNFR-associated factors (TRAF)3, TRAF2, and cellular inhibitor of apoptosis (cIAP)...
  41. ncbi Involvement of stress in the sleep rebound mechanism induced by sleep deprivation in the rat: use of alpha-helical CRH (9-41)
    M M Gonzalez
    Departement de Medecine Experimentale, INSERM U480, Faculte de Medecine, Universite Claude Bernard, Lyon, France
    Behav Pharmacol 9:655-62. 1998
    ..Rats were subjected for 10 h to the classical water-tank sleep-deprivation technique and were given, every 2 h throughout the sleep deprivation period, ..
  42. ncbi [An outbreak of waterborne Cryptosporidiosis in Kanagawa, Japan]
    T Kuroki
    Department of Bacteriology and Pathology, Kanagawa Prefectural Public Health Laboratory
    Kansenshogaku Zasshi 70:132-40. 1996
    ..0%) of the 25 stool samples. The oocysts were also found in tap water and other water samples from a receiving tank which was directly connected with the public waterworks, and an elevated tank on the roof, a wastewater pits, a ..
  43. pmc Specificities of CD40 signaling: involvement of TRAF2 in CD40-induced NF-kappaB activation and intercellular adhesion molecule-1 up-regulation
    H H Lee
    Department of Microbiology and Molecular Genetics, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 96:1421-6. 1999
    Several tumor necrosis factor receptor-associated factor (TRAF) family proteins including TRAF2, TRAF3, TRAF5, and TRAF6, as well as Jak3, have been implicated as potential mediators of CD40 signaling...
  44. pmc The role of TRAF2 binding to the type I interferon receptor in alternative NF kappaB activation and antiviral response
    Chuan He Yang
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, and the Center for Cancer Research, Memphis, TN 38163, USA
    J Biol Chem 283:14309-16. 2008
    ..of p50-containing NFkappaB complexes, as well as an alternative pathway that involves NFkappaB-inducing kinase and TRAF2, which results in the formation of p52-containing NFkappaB complexes...
  45. ncbi Fish tank granuloma in a 14-month-old girl
    E L Speight
    Department of Dermatology, University Hospital, Queen's Medical Centre, Nottingham, England
    Pediatr Dermatol 14:209-12. 1997
    ..A clinical diagnosis of fish tank granuloma was suspected because of tropical fish tanks at home...
  46. ncbi TRAF2 is essential for TNF-alpha-induced osteoclastogenesis
    Kiyoshi Kanazawa
    Department of Life Science, Tokyo Institute of Technology, Yokohama, Japan
    J Bone Miner Res 20:840-7. 2005
    b>TRAF2-deficient mice show embryonic lethality, and we developed a new in vitro differentiation system to show the function of TRAF2 in osteoclastogenesis, in which osteoclast progenitors are derived from the fetal liver of TRAF2-..
  47. doi A prospective matched nested case-control study of bacterial gill disease outbreaks in Ontario, Canada government salmonid hatcheries
    Christopher M Good
    The Conservation Fund s Freshwater Institute, 1098 Turner Road, Shepherdstown, WV 25443, USA
    Prev Vet Med 95:152-7. 2010
    ..Ongoing husbandry data were collected on all early-rearing (<9 months of age) fish tank-lots ("tank-lot"=a group of fish from a specific lot existing in a single hatchery tank for a given period during ..
  48. pmc Epstein-Barr virus-encoded latent membrane protein 1 activates the JNK pathway through its extreme C terminus via a mechanism involving TRADD and TRAF2
    A G Eliopoulos
    CRC Institute for Cancer Studies, The University of Birmingham Medical School, Birmingham B15 2TA, England
    J Virol 73:1023-35. 1999
    ..appears to be attributable to the direct interaction of tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2), while recent work indicates that CTAR2-induced NF-kappaB is mediated through its association with TNF receptor-..
  49. ncbi Control of Glossina longipennis (Diptera: Glossinidae) by insecticide-treated targets at Galana ranch, Kenya, and confirmation of the role of G. longipennis as a vector of cattle trypanosomiasis
    J N Makumi
    Kenya Trypanosomiasis Research Institute, PO Box 362, Kikuyu, Kenya
    Bull Entomol Res 90:397-406. 2000
    Glossina longipennis Corti was studied in Galana Ranch, Kenya over a four year period, in two areas (Tank E and Lali) where the species was abundant and other species were absent or scarce...
  50. pmc A critical approach to stress-related disorders in African Americans
    J S Mattis
    Department of Psychology, University of Michigan, Ann Arbor 48109 1109, USA
    J Natl Med Assoc 91:80-5. 1999
    ..It is the product of the work of an African-American mental health think tank situated at the Community Mental Health Council, Chicago, Illinois...
  51. ncbi Risk evaluation for staphylococcal food poisoning in processed milk produced with skim milk powder
    T Soejima
    Analytical Research Center, Morinaga Milk Industry Co, Ltd, 5 1 83 Higashihara, Zama, Kanagawa 228 8583, Japan
    Int J Food Microbiol 115:29-34. 2007
    ..enterotoxin A (SEA) in skim milk concentrates stored at inappropriate temperatures in a recovery milk tank (tank for excess concentrated skim milk) used in the manufacture of skimmed milk powder were investigated...
  52. ncbi Signaling pathways from membrane lipid rafts to JNK1 activation in reactive nitrogen species-induced non-apoptotic cell death
    Y T Wu
    Department of Community, Occupational and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    Cell Death Differ 15:386-97. 2008
    ..Next, we identified tumor necrosis factor receptor-associated factor 2 (TRAF2) and apoptosis signal-regulating kinase 1 (ASK1) as the essential upstream molecules for RNS-induced JNK ..
  53. pmc TRAF3 controls activation of the canonical and alternative NFkappaB by the lymphotoxin beta receptor
    Pradeep Bista
    Department of Immunology, Biogen Idec, Inc, Cambridge, Massachusetts 02142, USA
    J Biol Chem 285:12971-8. 2010
    Components of lymphotoxin beta receptor (LTBR)-associated signaling complexes, including TRAF2, TRAF3, NIK, IKK1, and IKK2 have been shown to participate in the coupling of LTBR to NFkappaB...
  54. ncbi Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein assoc
    T Yuasa
    Diabetes Research Laboratory, Medical Services, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Biol Chem 273:22681-92. 1998
    ..germinal center kinase (GCK) can interact in vivo with the TNFR1 signal transducer TNFR-associated factor-2 (TRAF2) and with MAPK/ERK kinase kinase 1 (MEKK1), a MAPK kinase kinase (MAPKKK) upstream of the SAPKs, thereby coupling ..
  55. ncbi Occurrence of Clostridium perfringens in the broiler chicken processing plant as determined by recovery in iron milk medium
    S E Craven
    USDA, ARS, R B Russell Agricultural Research Center, Athens, Georgia 30604 5677, USA
    J Food Prot 64:1956-60. 2001
    ..perfringens in the water of the scald tank, the water of the chill tank, and the rinse water of the processed carcasses from modern broiler chicken processing ..
  56. ncbi Anxiolytic effects of nicotine in zebrafish
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, USA
    Physiol Behav 90:54-8. 2007
    ..When zebrafish are placed in a novel environment, they dive to the bottom of the tank. In the wild, diving could help to escape predation...
  57. ncbi [Microbial community structure of beer wastewater treatment plants analyzed by PCR-DGGE technique]
    Ji Hong Zhao
    School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou 450001, China
    Huan Jing Ke Xue 29:2950-5. 2008
    ..Activated sludge samples were collected from both hydrolyze-acidification tank and SBR tank at different depth and disposal period...
  58. doi Evaluation of enzyme-linked immunosorbent assay using milk samples as a potential screening test of bovine tuberculosis of dairy cows in Korea
    Bo Young Jeon
    Department of Microbiology and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 120 752 Seoul, Republic of Korea
    Res Vet Sci 88:390-3. 2010
    An enzyme-linked immunosorbent assay (ELISA) using bulk tank milk samples was evaluated as a screening test for bovine tuberculosis (TB), a contagious chronic disease of cattle...
  59. doi Management practices associated with the bulk-milk prevalence of Staphylococcus aureus in Canadian dairy farms
    Richard G M Olde Riekerink
    Department of Health Management, University of Prince Edward Island, 550 University Avenue, C1A 4P3 Charlottetown, Canada
    Prev Vet Med 97:20-8. 2010
    ..and (3) associations of certain management practices with the isolation of Staphylococcus aureus from the bulk tank milk from Canadian dairy farms...
  60. ncbi Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation
    S Aizawa
    Department of Pathology, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108, Japan
    J Biol Chem 272:2042-5. 1997
    ..with two tumor necrosis factor receptor-associated factor (TRAF) proteins with NFkappaB activating capacity, TRAF2 and TRAF5. TRAF5 is the newest member of the TRAF family that binds to lymphotoxin beta receptor and CD40...
  61. ncbi Nuclear factor kB-independent cytoprotective pathways originating at tumor necrosis factor receptor-associated factor 2
    G Natoli
    Fondazione Andrea Cesalpino, Policlinico Umberto I, University of Rome La Sapienza, Viale del Policlinico 155, 00161 Rome, Italy
    J Biol Chem 273:31262-72. 1998
    ..Cellular resistance to TNF requires TNF receptor-associated factor 2 (TRAF2), which has been hypothesized to act mainly by mediating activation of the transcription factors nuclear factor kB ..
  62. pmc Regulation of the subcellular localization of tumor necrosis factor receptor-associated factor (TRAF)2 by TRAF1 reveals mechanisms of TRAF2 signaling
    Joseph R Arron
    Tri Institutional MD PhD Program, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 196:923-34. 2002
    ..Upon receptor engagement, TRAF2 is recruited to CD40 and translocates to lipid rafts in a RING finger-dependent process, which enables the ..
  63. ncbi Comparison of antimicrobial susceptibility of Staphylococcus aureus isolated from bulk tank milk in organic and conventional dairy herds in the midwestern United States and Denmark
    K Sato
    College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824 1314, USA
    J Food Prot 67:1104-10. 2004
    ..was conducted to compare the antimicrobial susceptibility patterns of Staphylococcus aureus isolated from bulk tank milk in organic and conventional dairy farms in Wisconsin, United States, and southern Jutland, Denmark...
  64. ncbi Characterization of Staphylococcus aureus strains isolated from bovine milk in Hungary
    F Peles
    Department of Food Processing, Quality Control, and Microbiology, Center of Agricultural Sciences, University of Debrecen, Boszormenyi ut 138, 4032 Debrecen, Hungary
    Int J Food Microbiol 118:186-93. 2007
    ..aureus isolates recovered from mammary quarter milk of mastitic cows and from bulk tank milk produced on Hungarian dairy farms of different sizes. Macrorestriction analysis of chromosomal DNA from S...
  65. doi Roles of TRAF2 and TRAF3 in Epstein-Barr virus latent membrane protein 1-induced alternative NF-kappaB activation
    Yoon Jae Song
    Department of Life Science, Kyungwon University, Kyeonggi Do, Korea
    Virus Genes 41:174-80. 2010
    ..While CTAR2 activates TRAF6, IKKbeta and IKKgamma-dependent canonical NF-kappaB pathway, CTAR1 interacts with TRAF2 and TRAF3 and activates NIK and IKKalpha-dependent alternative NF-kappaB pathway involving p100 processing into ..
  66. ncbi Exposure of a liquefied gas container to an external fire
    Phani K Raj
    Technology and Management Systems, Inc, Burlington, MA 01803, USA
    J Hazard Mater 122:37-49. 2005
    In liquefied gas, bulk-storage facilities and plants, the separation distances between storage tanks and between a tank and a line of adjoining property that can be built are governed by local regulations and/or codes (e.g...
  67. ncbi Assessment of alternative management techniques of tank bottom petroleum sludge in Oman
    Ahmed Al-Futaisi
    Department of Civil and Architectural Engineering, Sultan Qaboos University, P O Box 33, Al Khoud 123, Oman
    J Hazard Mater 141:557-64. 2007
    This paper investigated several options for environmentally acceptable management techniques of tank bottom oily sludge...
  68. ncbi Effects of acoustic alarms, designed to reduce small cetacean bycatch in gillnet fisheries, on the behaviour of North Sea fish species in a large tank
    Ronald A Kastelein
    Sea Mammal Research Company SEAMARCO, Julianalaan 46, 3843 CC Harderwijk, The Netherlands
    Mar Environ Res 64:160-80. 2007
    ..the effects of seven commercially-available pingers on the behaviour of five North Sea fish species in a large tank were quantified...
  69. ncbi RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation
    Haifeng Zhang
    Interdepartmental Program in Vascular Biology and Transplantation, Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 282:14788-96. 2007
    ..family, opens its conformation in response to tumor necrosis factor (TNF), allowing it to form a complex with TRAF2-ASK1 that leads to activation of ASK1-JNK/p38 signaling in endothelial cells (EC)...
  70. pmc Structural basis for the lack of E2 interaction in the RING domain of TRAF2
    Qian Yin
    Weill Medical College of Cornell University, New York, New York 10021, USA
    Biochemistry 48:10558-67. 2009
    TRAF proteins are intracellular signal transducers for a number of immune receptor superfamilies. Specifically, TRAF2 interacts with members of the TNF receptor superfamily and connects the receptors to downstream signaling proteins...
  71. ncbi Exposure to methyl tert-butyl ether and tert-amyl methyl ether from gasoline during tank lorry loading and its measurement using biological monitoring
    S Vainiotalo
    Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Helsinki
    Int Arch Occup Environ Health 71:391-6. 1998
    The exposure of Finnish tank lorry drivers to methyl tert-butyl ether (MTBE) and tert-amyl methyl ether (TAME) during loading of gasoline was studied using biological and breathing-zone sampling...
  72. ncbi Microbial community analysis of a biogas-producing completely stirred tank reactor fed continuously with fodder beet silage as mono-substrate
    Michael Klocke
    Leibniz Institut für Agrartechnik Potsdam Bornim e V, Abteilung Bioverfahrenstechnik, Max Eyth Allee 100, D 14469 Potsdam Bornim, Germany
    Syst Appl Microbiol 30:139-51. 2007
    ..of renewable raw material to biogas by anaerobic microbial fermentation processes in completely stirred tank reactors (CSTR) is a valuable alternative resource of energy especially for rural areas...
  73. ncbi Associations between anti-Fasciola hepatica antibody levels in bulk-tank milk samples and production parameters in dairy herds
    Johannes Charlier
    Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Prev Vet Med 78:57-66. 2007
    Our primary objective was to determine the relationships between Fasciola-specific antibody levels in bulk-tank milk and measures of productivity to estimate economic losses that are associated with Fasciola infections...
  74. ncbi [Arrhythmia and vago-sympathetic equilibrium in athletic divers]
    A Bonneau
    INSERM U 138, CHU Henri-Mondor,
    Arch Mal Coeur Vaiss 82:99-105. 1989
    ..recordings by the Holter method were performed in 16 athletic divers : the first series in a man-made tank 15 m deep and containing water at 28 degrees C, with only exercises in apnoea ; the second series in a natural ..
  75. ncbi A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction
    Y C Park
    Department of Biochemistry, Weill Medical College and Graduate School of Medical Sciences of Cornell University, New York, New York 10021, USA
    Cell 101:777-87. 2000
    ..We now report the structure of the TRADD-TRAF2 complex, which is highly distinct from receptor-TRAF2 interactions...
  76. ncbi Effects of flotation-REST on muscle tension pain
    A Kjellgren
    Department of Psychology, Karlstad University, Karlstad, Sweden
    Pain Res Manag 6:181-9. 2001
    ..Flotation-REST consists of a procedure whereby an individual is immersed in a tank filled with water of an extremely high salt concentration...
  77. ncbi A novel RING finger protein interacts with the cytoplasmic domain of CD40
    H M Hu
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109
    J Biol Chem 269:30069-72. 1994
    ..to the tumor necrosis factor receptor-associated factor (TRAF) domain that is found in two proteins (TRAF1 and TRAF2) that associate with the cytoplasmic domain of the related 75-kDa tumor necrosis factor receptor...
  78. ncbi Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase
    B G Darnay
    Cytokine Research Laboratory, Department of Molecular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 273:20551-5. 1998
    ..From this deletion analysis, we determined that TRAF2, TRAF5, and TRAF6 interact with RANK at its C-terminal 85-amino acid tail; the binding affinity appeared to be in ..
  79. ncbi Aerosol-bound emissions of polycyclic aromatic hydrocarbons and sterols from aeration tanks of a municipal waste water treatment plant
    Michael Radke
    Chair of Hydrology, University of Bayreuth, 95440 Bayreuth, Germany
    Environ Sci Technol 37:2109-13. 2003
    ..Aerosol emissions from an activated treatment tank equipped with fine bubble diffusers were low; however, at the preaeration tank equipped with coarse bubble ..
  80. ncbi Conservation principles suspended solids distribution modelling to support ATS introduction on a recirculating WWTP
    Krist V Gernaey
    CAPEC, Department of Chemical Engineering, Technical University of Denmark, DK 2800 Lyngby, Denmark
    Water Sci Technol 50:179-88. 2004
    ..predictions of the SS load to the secondary clarifiers, an essential variable for the operation of the aeration tank settling (ATS) process...
  81. pmc Sequestration of TRAF2 into stress granules interrupts tumor necrosis factor signaling under stress conditions
    Woo Jae Kim
    National Research Laboratory, Postech Biotech Center, Department of Life Science, Division of Molecular and Life Sciences, Pohang University of Science and Technology, Hyoja Dong San 31, Pohang, Kyungbuk 790 784, Korea
    Mol Cell Biol 25:2450-62. 2005
    ..Here we report that eIF4GI, which is a scaffold protein interacting with many translation factors, interacts with TRAF2, a signaling molecule that plays a key role in activation of NF-kappaB through TNF-alpha...
  82. pmc Localized recruitment and activation of RhoA underlies dendritic spine morphology in a glutamate receptor-dependent manner
    Vanessa Schubert
    Cavalieri Ottolenghi Scientific Institute, Universita degli Studi di Torino, Azienda Ospedaliera San Luigi Gonzaga, Regione Gonzole 10, 10043 Orbassano Torino, Italy
    J Cell Biol 172:453-67. 2006
    ..M., and S.B. Kater. 1994. Annu. Rev. Neurosci. 17:341-371; Yuste, R., and D.W. Tank. 1996. Neuron. 16:701-716)...
  83. ncbi Development of a tri-polar concentric ring electrode for acquiring accurate Laplacian body surface potentials
    W Besio
    Department of Biomedical Engineering, Louisiana Tech University, Ruston, LA 71270, USA
    Ann Biomed Eng 34:426-35. 2006
    ..of bipolar, quasi-bipolar and tri-polar concentric ring electrodes were evaluated and compared, and verified with tank experiments...
  84. ncbi Multiple equilibria in complex chemical reaction networks: extensions to entrapped species models
    G Craciun
    Mathematical Biosciences Institute, Ohio State University, Columbus, OH 43210, USA
    Syst Biol (Stevenage) 153:179-86. 2006
    ..kinetics, to admit multiple equilibria in the context of the isothermal homogeneous continuous flow stirred tank reactor (CFSTR)...
  85. ncbi Five new CYLD mutations in skin appendage tumors and evidence that aspartic acid 681 in CYLD is essential for deubiquitinase activity
    Stephanie Almeida
    Service of Dermatology, University Hospital Center and University of Lausanne, Lausanne, Switzerland
    J Invest Dermatol 128:587-93. 2008
    ..NF-kappaB activation, tumor necrosis factor-alpha (TNFalpha)-induced JNK signaling, and to deubiquitinate TRAF2. CYLD-D681G was coimmunoprecipitated by TRAF2, but was unable to cleave K63-linked polyubiquitin chains...
  86. doi Field note phytovolatilization of oxygenated gasoline-impacted groundwater at an underground storage tank site via conifers
    C W Arnold
    California Water Resources Control Board, Division of Water Quality, Sacramento, California 95814, USA
    Int J Phytoremediation 9:53-69. 2007
    ..Stand evapotranspiration was calculated using meteorological data from the California Irrigation Management Information System (CIMIS) applied in the Standardized Reference Evapotranspiration Equation...
  87. doi Local and disseminated infections caused by Mycobacterium marinum: an unusual cause of subcutaneous nodules
    Leena G Adhikesavan
    Department of Rheumatology, Geisinger Health System, Danville, PA 17822, USA
    J Clin Rheumatol 14:156-60. 2008
    ..and developed disseminated infection requiring prolonged treatment, and one had direct exposure to fish and fish tank. M...
  88. doi Total nitrogen removal in a hybrid, membrane-aerated activated sludge process
    Leon S Downing
    Department of Civil Engineering and Geological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
    Water Res 42:3697-708. 2008
    ..Air-filled hollow-fiber membranes are incorporated into an activated sludge tank, and a nitrifying biofilm develops on the membranes, producing nitrite and nitrate...
  89. doi Potentials to differentiate milk composition by different feeding strategies
    T Slots
    Department of Food Science, Faculty of Agricultural Sciences, University of Aarhus, Blichers alle 20, PO Box 50, DK 8830 Tjele, Denmark
    J Dairy Sci 92:2057-66. 2009
    To investigate the effect of the dietary intake of the cow on milk composition, bulk-tank milk was collected on 5 occasions from conventional (n = 15) and organic (n = 10) farms in Denmark and on 4 occasions from low-input nonorganic ..
  90. doi New avian suspension cell lines provide production of influenza virus and MVA in serum-free media: studies on growth, metabolism and virus propagation
    V Lohr
    Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Sandtorstr 1, 39106 Magdeburg, Germany
    Vaccine 27:4975-82. 2009
    ..metabolism was studied during growth in static (T-flasks) and dynamic cultivation systems (roller bottles, stirred tank reactor, wave bioreactor). High cell concentrations up to 5...
  91. pmc Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response
    Tatsuya Saitoh
    Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 106:20842-6. 2009
    ..show that the translocation and assembly of the essential signal transducers, stimulator of IFN genes (STING) and TANK-binding kinase 1 (TBK1), are required for dsDNA-triggered innate immune responses...
  92. doi The impact of co-contaminants and septic system effluent quality on the transport of estrogens and nonylphenols through soil
    Benjamin D Stanford
    Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, CB 7431, Chapel Hill, NC 27599 7431, USA
    Water Res 44:1598-606. 2010
    ..Biodegradation of the steroids in soil was also lower in the presence of septic tank effluents than in an organic-free control water...
  93. doi Experimental testing of the noise-canceling processor
    Michael D Collins
    Naval Research Laboratory, Stennis Space Center, Mississippi 39529, USA
    J Acoust Soc Am 130:1217-21. 2011
    Signal-processing techniques for localizing an acoustic source buried in noise are tested in a tank experiment. Noise is generated using a discrete source, a bubble generator, and a sprinkler...
  94. doi Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are required for efficient caspase-1 activation by the inflammasome
    Katherine Labbe
    Department of Microbiology and Immunology, McGill University, Montreal, Quebec H3G 0B1, Canada
    Immunity 35:897-907. 2011
    ..cIAP1, cIAP2, and the adaptor protein TRAF2 interacted with caspase-1-containing complexes and mediated the activating nondegradative K63-linked ..
  95. doi Recommendations for a definition of multiple sclerosis in support of early treatment
    H Zephir
    pôle de neurologie, Universite Lille Nord de France, Hopital Roger Salengro, CHRU de Lille, 1, rue du Professeur Emile Laine, 59037 Lille, France
    Rev Neurol (Paris) 168:328-37. 2012
    The aim of the Multiple Sclerosis Think Tank (Groupe de Réflexion sur la Sclérose en Plaques: GRESEP), composed of hospital neurologists involved in the management of patients with multiple sclerosis, is to provide recommendations in ..
  96. pmc IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication
    Martin R Jakobsen
    Department of Biomedicine and Aarhus Research Center for Innate Immunology, Aarhus University, 8000 Aarhus C, Denmark
    Proc Natl Acad Sci U S A 110:E4571-80. 2013
    ..protein 16 (IFI16), which bound immunostimulatory DNA directly and activated the stimulator of IFN genes -TANK-binding kinase 1 - IFN regulatory factors 3/7 (STING-TBK1-IRF3/7) pathway...
  97. doi Fe(III) reduction-mediated phosphate removal as vivianite (Fe3(PO4)2⋅8H2O) in septic system wastewater
    Hossain M Azam
    Civil and Environmental Engineering, University of Illinois, Urbana, IL, United States Electronic address
    Chemosphere 97:1-9. 2014
    ..conditions; a system must be amended specifically with compounds to bond to or adsorb phosphate in the septic tank or within the leach field...
  98. doi Multi-isotope (carbon and chlorine) analysis for fingerprinting and site characterization at a fractured bedrock aquifer contaminated by chlorinated ethenes
    Jordi Palau
    Departament de Cristal lografia, Mineralogia i Diposits Minerals, Facultat de Geologia, Universitat de Barcelona, Marti i Franques, s n 08028 Barcelona, Spain Electronic address
    Sci Total Environ 475:61-70. 2014
    ..The potential sources of contamination including abandoned barrels, an underground tank, and a disposal lagoon, showed a wide range in δ(13)C values from -15.6 to -40.5‰ for TCE and from -18.5 to -32...
  99. doi pH oscillations and mechanistic analysis in the hydrogen peroxide-sulfite-thiourea reaction system
    Ling Yuan
    College of Chemical Engineering, China University of Mining and Technology, Xuzhou 221116, P R China
    J Phys Chem A 118:2702-8. 2014
    ..oligo-oscillatory behavior in a closed system, and large amplitude oscillations in a continuous-flow stirred tank reactor (CSTR) were observed in a narrow range of input concentrations, flow rate, and temperature...
  100. doi Assessing the influence of CH4 concentration during culture enrichment on the biodegradation kinetics and population structure
    Juan C Lopez
    Department of Chemical Engineering and Environmental Technology, University of Valladolid, Dr Mergelina, S N, 47011, Valladolid, Spain
    J Environ Manage 146:116-23. 2014
    Methanotrophic communities were enriched in three stirred tank reactors continuously supplied with CH4-laden air at 20, 2 and 0...
  101. doi Making lignin accessible for anaerobic digestion by wet-explosion pretreatment
    Birgitte K Ahring
    BioProducts, Sciences and Engineering Laboratory BSEL, Washington State University, USA Electronic address
    Bioresour Technol 175:182-8. 2015
    ..performed in a 10L reactor at 170°C for 25min using 4bars oxygen and the material was fed to a continuous stirred tank reactor operated at 55°C for anaerobic digestion...

Research Grants64

  1. Development of an Acoustic Biological Shaker
    TODD MCADAMS; Fiscal Year: 2005
    ..drawbacks that include low oxygen transfer capability and limited applicability when scaling up to stirred-tank bioreactors...
  2. Multi-component In Situ Chemical Analyzer for Cell Culture Processes
    RONALD MICHEELS; Fiscal Year: 2007
    ..vessels including roller bottles, T-flasks, shake flasks, spinner bottles, disposable bag bioreactors, and stirred tank bioreactors...
  3. ENHANCED ROLLER BOTTLE
    John Wilson; Fiscal Year: 2003
    ..Culture devices, such as stirred-tank and hollow fiber bioreactors, have utility in large-scale production, but are impractical and cost prohibitive at ..
  4. Negative regulation of NF-kB and inflammation by TAX1BP1
    Edward W Harhaj; Fiscal Year: 2012
    ..mechanisms by which TAX1BP1 inhibits persistent NF-kB activation;(2) the mechanism by which TAX1BP1 inhibits TRAF2 ubiquitination;and (3) the role of phosphorylation in TAX1BP1 function...
  5. GAMMA DELTA T CELLS IN LYME ARTHRITIS
    Ralph C Budd; Fiscal Year: 2011
    ..This occurs via recruitment to c-FLIP of the adaptor proteins, RIP1 and TRAF2. TLR signaling of DC may also require caspase-8 and connect via TRAF6...
  6. Heat Shock-Induced Apoptosis
    Shawn B Bratton; Fiscal Year: 2012
    ..TIA-1, and that SGs in turn activate JNKs through a tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and TGF2- activating kinase 1 (TAK1)-dependent pathway...
  7. DOUGLAS LOWELL MANN; Fiscal Year: 2016
    ..Noting that TRAF2 (tumor necrosis factor receptor associated factor 2) was the only signaling protein that was common to both ..
  8. Cytoprotective cytokine signaling and reperfusion injury
    DOUGLAS LOWELL MANN; Fiscal Year: 2010
    ..Noting that the only signaling protein that was common to both receptors was a signaling protein termed TRAF2 (tumor necrosis factor receptor associated factor 2), we have performed experiments in isolated cardiac myocytes, ..
  9. BTK SIGNALING IN B CELL SURVIVAL BY BAFF-R
    Wasif N Khan; Fiscal Year: 2011
    ..Preliminary data further suggests that (i) Btk interfaces with BAFF-R via mechanisms involving TRAF2 and cIAP2, and (ii) Btk kinase function is necessary for BAFF- R-mediated activation of the classical pathway in ..
  10. The role of MCPIP1 in regulating NF-kB signaling and macrophage activation
    Mingui Fu; Fiscal Year: 2012
    ..together with a greatly increased NF-[unreadable]B activation, as well as increased polyubiquitination of TRAF2 and TRAF6. Furthermore, in vitro assay directly demonstrated the deubiquitinating activity of purified MCPIP1...
  11. Role of a novel IKK-related kinase in inflammation
    SUSAN ELAINE SWEENEY; Fiscal Year: 2010
    ..The IKK-related kinases, inducible IKK (IKKi) and TANK-binding kinase 1 (TBK1) were as originally identified as NF-kB activating kinases that phosphorylated IkB...
  12. Carol A Mancuso; Fiscal Year: 2014
    ..In particular, the candidate is an active member of the Research Methodology Core, a 'think tank'of established multi-disciplinary clinical researchers focusing on challenges in research methodology and the ..
  13. Katherine A Fitzgerald; Fiscal Year: 2016
    ..inflammasome while IFI16 activates a cytosolic signaling pathway involving Stimulator of IFN genes (STING), TANK binding kinase-1 (TBK-1) and interferon regulatory factor 3 (IRF3) to regulate transcription of type I IFN genes...
  14. Ha Linh Vu; Fiscal Year: 2016
    ..One protein that may prove to be important in this group is TANK-binding kinase 1 (TBK1), an atypical IkB kinase family member...
  15. RICARDO C AGUIAR; Fiscal Year: 2016
    ..and characterize the miRNAs that directly target the positive NF-[unreadable]B regulators CARD11, MYD88, CD79B, TRAF2, TRAF5 and TAK1;3...
  16. Role of Mixed Lineage Kinase 3/SPRK in Stress Signaling
    AJAY NMN RANA; Fiscal Year: 2010
    ..MLK3, (ii) MLK3 mediates TNF-a and ceramide-induced JNK activation, (iii) TNF-a treatment of Jurkat cells triggers TRAF2 association with MLK3, (vi) overexpression of MLK3 causes cell death, and (v) Retinoic acid induced HL-60 cell ..
  17. Impact of the interferon regulated proteins XAF1 and ZNF313 on innate immunity
    Douglas W Leaman; Fiscal Year: 2010
    ..will also pursue recent data linking XAF1 to other signaling molecules that regulate ubiquitin ligation, including TRAF2 and RIP2, and demonstrate that TRIP6, another XAF1 binding partner, may represent a novel ubiquitination regulator ..
  18. Treatment of Sleep Apnea using a Positive Airway Pressure Rebreathing Modulator
    Matthew D Tarler; Fiscal Year: 2011
    ..By controlled mixing, we hope to completely eliminate the need for the high pressure tank, or at a minimum markedly increase its life...
  19. Lalita Ramakrishnan; Fiscal Year: 2014
    ..a systemic tuberculosis-like disease in ectotherms, and a peripheral granulomatous disease in humans called fish tank granuloma. M...
  20. Kang Kim; Fiscal Year: 2014
    ..The study will include computer simulations for beamforming and tissue thermal model, water tank experiments using the tissue mimicking phantoms, the human tissue specimens from autopsy, amputation and carotid ..
  21. Inflammation and the esophageal tumor microenvironment
    TIMOTHY CRAGIN WANG; Fiscal Year: 2013
    ..is in concert with the recommendations by the NCI progress group report on upper Gl cancers, and the NCI Think Tank recommendations on the Tumor Microenvironment as well as Inflammation and Cancer...
  22. Wayne A Gordon; Fiscal Year: 2016
    ..A new element of MS-ICRC outreach will be a Policy Think Tank, to review evidence based on MS-ICRC research and from the established knowledge base, and then to detail means and ..
  23. Functional Neuroanatomy of Approach and Avoidance Behavior
    EDWARD CLIFTON HURLOCK; Fiscal Year: 2010
    ..In both aims, preference will be assessed in a light/dark choice tank by measuring time spent in light and dark compartments...
  24. FRANCES LOUISA TITUS; Fiscal Year: 2015
    ..LMP-1 interaction with Smurf1 is predicted to inhibit degradation of signaling molecules including Smad1, Smad5, Traf2, making them more available to mediate events leading to enhanced expression of Wnt10b...
  25. Huang Ge Zhang; Fiscal Year: 2014
    ..Urethane treatment results in the recruitment of the activated form of TRAF2 to the exosomes, and the exosomes with activated TRAF2 are taken up by the bone marrow-derived precursors of ..
  26. Sarah Spiegel; Fiscal Year: 2015
    ..In preliminary studies, we have discovered that TNF receptor-associated factor 2 (TRAF2), a key component in activation of NF-kB, is another novel intracellular target of S1P...
  27. Regulation of Type I Interferon Gene Expression in the Innate Immune Response
    Katherine A Fitzgerald; Fiscal Year: 2012
    ..b>TANK-binding kinase (TBK1) is a central signaling hub in nucleic acid sensing pathways...
  28. JEFFREY LEE GAUTHIER; Fiscal Year: 2014
    ..To investigate these mechanisms in the context of navigation, the Tank lab has recently developed new technology for calcium imaging and electrophysiological recordings to be performed ..
  29. Deepak Shukla; Fiscal Year: 2014
    ..The first Aim will focus on the possibility that HSV-1 infection interferes with OPTN phosphorylation by TANK binding kinase-1 (TBK1), which in turn results in the inhibition of autophagy induction and interferon production, ..
  30. DEBORAH LYNN GALSON; Fiscal Year: 2016
    ..IKK)-related kinases IKKe (also called IKK-/) and TANK-binding kinase 1 (TBK1) and increased levels of RIP1 and TRAF2. This results in upregulation of IL-6 and a vitamin D receptor coactivator TAFM-17 and increases OCL formation...
  31. lung tumor exosome-mediated inflammation promotes tumor progression and growth
    Huang Ge Zhang; Fiscal Year: 2010
    ..Urethane treatment results in the recruitment of the activated form of TRAF2 to the exosomes, and the exosomes with activated TRAF2 are taken up by the bone marrow-derived precursors of ..
  32. NKIP signaling and functions
    John Cambier; Fiscal Year: 2009
    ..b>TRAF2 and TRAF6 are two TRAF family proteins that are essential components in TNF-, IL-1- and TLRs-induced NF-?B ..
  33. Mechanisms of Alteration of B Lymphocyte Function by LMP1
    Gail A Bishop; Fiscal Year: 2013
    ..We recently discovered that LMP1 signaling is independent of TRAF2, a major mediator of CD40 signals, but that TRAFs 3, 5, and 6 make important contributions to LMP1 effects in B ..
  34. RANK-Associated Inhibitor (RAIN) in Osteoclast Formation
    Bryant Darnay; Fiscal Year: 2007
    ..interacts with TRAF1, 2, 3, 5, and 6, and our laboratory described the distinct regions of RANK that interact with TRAF2, 5, and 6...
  35. High throughput behavior monitoring and screening station for zebrafish larvae
    PIERRE R MARTINEAU; Fiscal Year: 2012
    ..images using consumer grade video cameras, we have designed a concept (nicknamed "Zebratrack") and implemented an 8-tank prototype (tanks are Petri dish - shaped 30mL containers) of a video-recording station to monitor, screen and ..
  36. TOMASZ J PETELENZ; Fiscal Year: 2016
    ..partners various resources at the University of Utah including the Bioengineering bioDesign program, Honors Think Tank and the School of Medicine to develop an empathetic, clinically centered experience for the engineering and design ..
  37. Transfusion Medicine/Hemostasis Clinical Trials Network
    Ellis J Neufeld; Fiscal Year: 2011
    ..In addition, specific new protocols are proposed, the result of network-wide "think tank" activities during 2006...
  38. Optimization of Core Animal Services at The Ohio State University
    JUDY MARIE HICKMAN-DAVIS; Fiscal Year: 2012
    ..The requested 224 tank 5-shelf aquatic rack will accommodate an additional 10,640 fish...
  39. Center for Clinical and Translational Sciences
    David D McPherson; Fiscal Year: 2010
    ..A CCTS "Think Tank" comprised of highly accomplished translational and clinical Investigators, basic scientists and educators, and ..
  40. Center for Clinical and Translational Sciences
    David D McPherson; Fiscal Year: 2011
    ..A CCTS "Think Tank" comprised of highly accomplished translational and clinical Investigators, basic scientists and educators, and ..
  41. Center for Clinical and Translational Sciences
    David D McPherson; Fiscal Year: 2011
    ..A CCTS "Think Tank" comprised of highly accomplished translational and clinical Investigators, basic scientists and educators, and ..
  42. A Center for the Convergence of Physical Science and Cancer Biology
    Paul Davies; Fiscal Year: 2013
    ..The conceptual driver of the program will be a Cancer Forum, a "think tank" that will critically examine the foundational assumptions of cancer research, and help develop fundamentally new ..
  43. Method for guiding ablative therapy of cardiac arrythmias
    Antonis A Armoundas; Fiscal Year: 2013
    ..We will evaluate its performance by means of saline tank and animal studies...
  44. 2D Silicon Transducer Compression Plates for Breast Ultrasound
    KAI ERIK THOMENIUS; Fiscal Year: 2010
    ..to be accomplished in order for the device to be fabricated and its performance validated initially in a test tank and finally in a clinic with a preclinical assessment...
  45. Integration of TNF Signaling in Apoptosis
    Anning Lin; Fiscal Year: 2010
    ..of the JNK signalsorne and negatively regulates TNF-induced JNK activation and cell death through suppression of TRAF2 K63-linked polyubiquitination...
  46. MECHANISMS OF IGE SYNTHESIS BY B CELLS
    Raif Geha; Fiscal Year: 2007
    ..examine the role of a). the TRAF interacting protein RIP, b). of the scaffold subunit of the I_kinase IKK}, .and c). the MAP kinases p38 and JNK...
  47. Weizhou Zhang; Fiscal Year: 2014
    ..the role of alternative NF-[unreadable]B pathways components, including NF-[unreadable]B inducing kinase (NIK), TRAF2, and TRAF3 in ErbB2-induced mammary tumor development and metastasis;and identify upstream members, if other than ..
  48. UMass BSL-3 Renovation
    JOHN LEWIS SULLIVAN; Fiscal Year: 2010
    ..Mechanical system renovations to the 6th and 8th floors and roof level will accommodate a new Biokill kill tank effluent decontamination system, mechanical controls, and a prefabricated mechanical unit, dedicated to serving the ..
  49. Role of TRAF1 in signaling by TNFR2 family members
    Erdyni Tsitsikov; Fiscal Year: 2007
    ..Each of TNFR2 family receptors may associate with one or several TRAF signal transduction molecules. TRAF2, TRAF3, TRAF5, and TRAF6 were shown to participate in signal transduction and activation of NF-kappaB and AP-1 ..
  50. CD40 SIGNAL TRANSDUCTION
    Claudius Vincenz; Fiscal Year: 1999
    ..to the tumor necrosis factor receptor-associated factor (TRAF) domain that is found in two proteins (TRAF1 and TRAF2) that associate with the cytoplasmic domain of the related 75kD tumor necrosis factor receptor...
  51. PRIMARY CARE RESEARCH METHODS & STATISTICS CONFERENCE
    Walter L Calmbach; Fiscal Year: 2010
    ..Thematic track, the Dissection of Innovative Studies Workshop, the Plenary Sessions, and the Methodological Think Tank process. Evaluation. Each conference session is evaluated by attendees and a session Moderator...
  52. COLLABORATIVE STUDY OF 1,3 BUTADIENE BIOMARKERS
    Thomas Smith; Fiscal Year: 2002
    ..during tank cleaning, and long-term low level (medians 0...
  53. CYLD Regulation of Epidermal Growth and Neoplasia
    YUNYAN JENNIFER ZHANG; Fiscal Year: 2009
    ..CYLD acts as a deubiquitinase that inhibits self-ubiquitination of TRAF2/TRAF6 proteins, the key adaptor molecules mediating signal transduction from cell surface receptors, and thereby ..
  54. CONTROL OF TNF SIGNALING BY NFKB
    ALBERT BALDWIN JR; Fiscal Year: 2003
    ..TRADD functions as an adapter to recruit to the receptor other important regulatory molecules such as FADD and TRAF2. TNF signaling leads to the activation of several important regulatory pathways, including: (1) the activation of ..
  55. Anning Lin; Fiscal Year: 2014
    ..Miz1 suppresses TNFalpha-induced K63-linked polyubiquitination of TRAF2, thereby only inhibiting activation of JNK but not ERK, p38 or IKK by TNFalpha, and only JNK activation by ..
  56. Inositol hexakisphosphate kinase 2:apoptosis regulator
    Daniel Lindner; Fiscal Year: 2006
    ..domain (IPBD) causes resistance to both the antiproliferative and anti-apoptotic functions of IFN-beta IP6K2 binds TRAF2, an inducer of NFKB activity. We hypothesize that IP6K2 inactivates TRAF2, inhibiting NFKappaB activation...
  57. TNFR ASSOCIATED FACTOR IN PULMONARY RESPONSE TO TNF-A
    Gloria Pryhuber; Fiscal Year: 2003
    ..spleen, thymus and testes suggesting tissue specific function, 2) it is highly regulated in lung cells, while TRAF2-6 are ubiquitously and constitutively expressed, 3) it forms heterodimers with other TRAF proteins and is ..
  58. Brian W Pogue; Fiscal Year: 2014
    ..in water tanks or tissue phantoms involve the use of ionization chambers, which are raster scanned in a 3D water tank, so that developing a 3D image of a beam would take the majority of a 24 hour day;therefore, it is rarely done...
  59. EXERCISE AND ANIMAL MODELS OF HYPERTENSION
    CHARLES TIPTON; Fiscal Year: 1992
    ..fore-limb hanging by rats is an effective isometric procedure; and the addition of weights to animals in a water tank is not physiologically desirable for swimming studies because of its submergence effects...
  60. MENA Think Tank Stigma and HIV Prevention
    ANKE EHRHARDT; Fiscal Year: 2009
    ..Health and the UCLA Program in Global Health, propose to conduct a Middle East/North Africa (MENA)-specific Think Tank on HIV/AIDS stigma and HIV prevention...
  61. Regulation of the Tp12 Kinase
    Philip Tsichlis; Fiscal Year: 2009
    ..Finally, Tpl2 binds the E3 ubiquitin ligases TRAF6 and TRAF2 and is required for the transduction of TRAF6, and perhaps TRAF2-induced signals...
  62. ASSEMBLY/REGULATION OF CD40 RECEPTOR COMPLEX IN B CELLS
    Randolph Noelle; Fiscal Year: 2001
    ..Preliminary data are presented that show that in a human B-cell line both TRAF2 and TRAF3 are recruited to the CD40 receptor complex within minutes of ligand binding...