tax

Summary

Gene Symbol: tax
Description: p40
Species: Human T-lymphotropic virus 1

Top Publications

  1. pmc The HTLV-1 hbz antisense gene indirectly promotes tax expression via down-regulation of p30(II) mRNA
    Gunjan Choudhary
    Division of Molecular Oncology, Washington University School of Medicine, St Louis, MO, USA
    Virology 410:307-15. 2011
  2. pmc Move or die: the fate of the Tax oncoprotein of HTLV-1
    Julie Lodewick
    Institut de Recherches Microbiologiques J M Wiame, Universite Libre de Bruxelles, B 1070 Bruxelles, Belgium
    Viruses 3:829-57. 2011
  3. pmc Activation of LTRs from different human endogenous retrovirus (HERV) families by the HTLV-1 tax protein and T-cell activators
    Chirine Toufaily
    Departement des Sciences Biologiques, Universite du Quebec a Montreal, SB R860, 2080 St Urbain, Montreal, Quebec, H2X 3X8, Canada
    Viruses 3:2146-59. 2011
  4. pmc Suppression of HTLV-1 replication by Tax-mediated rerouting of the p13 viral protein to nuclear speckles
    Vibeke Andresen
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD, USA
    Blood 118:1549-59. 2011
  5. pmc Human T-lymphotropic virus type 1 transcription and chromatin-remodeling complexes
    Rebecca Easley
    Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University, 2300 I St, NW, Ross Hall, Room 551, Washington, DC 20037, USA
    J Virol 84:4755-68. 2010
  6. pmc An RNA interference screen identifies the Deubiquitinase STAMBPL1 as a critical regulator of human T-cell leukemia virus type 1 tax nuclear export and NF-κB activation
    Alfonso Lavorgna
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami, Miller School of Medicine, Miami, Florida, USA
    J Virol 86:3357-69. 2012
  7. ncbi Dose-dependent dual effect of HTLV-1 tax oncoprotein on p53-dependent nucleotide excision repair in human T-cells
    Yana Schavinsky-Khrapunsky
    The Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences and Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Int J Cancer 122:305-16. 2008
  8. doi Human T-cell leukemia virus type 1 Tax modulates interferon-alpha signal transduction through competitive usage of the coactivator CBP/p300
    Jing Zhang
    Research and Development Center, Fuso Pharmaceutical Industries, Ltd, 2 3 30 Morinomiya, Joto ku, Osaka 536 8523, Japan
    Virology 379:306-13. 2008
  9. doi The avidity and lytic efficiency of the CTL response to HTLV-1
    Tarek Kattan
    Department of Immunology, Wright Fleming Institute, Imperial College London, United Kingdom
    J Immunol 182:5723-9. 2009
  10. doi Clonal expansion of HTLV-1 positive CD8+ cells relies on cIAP-2 but not on c-FLIP expression
    Linda Zane
    CNRS UMR5239, Universite de Lyon, Oncovirologie et Biothérapies, Centre Leon Berard, 69008 Lyon, France
    Virology 407:341-51. 2010

Research Grants

Scientific Experts

Detail Information

Publications105 found, 100 shown here

  1. pmc The HTLV-1 hbz antisense gene indirectly promotes tax expression via down-regulation of p30(II) mRNA
    Gunjan Choudhary
    Division of Molecular Oncology, Washington University School of Medicine, St Louis, MO, USA
    Virology 410:307-15. 2011
    ..with a splice acceptor mutation that disrupts expression of the predominant hbz mRNA resulted in lower levels of tax mRNA. Heterologous hbz expression restored Tax activity in cells expressing this mutant clone...
  2. pmc Move or die: the fate of the Tax oncoprotein of HTLV-1
    Julie Lodewick
    Institut de Recherches Microbiologiques J M Wiame, Universite Libre de Bruxelles, B 1070 Bruxelles, Belgium
    Viruses 3:829-57. 2011
    The HTLV-1 Tax protein both activates viral replication and is involved in HTLV-1-mediated transformation of T lymphocytes...
  3. pmc Activation of LTRs from different human endogenous retrovirus (HERV) families by the HTLV-1 tax protein and T-cell activators
    Chirine Toufaily
    Departement des Sciences Biologiques, Universite du Quebec a Montreal, SB R860, 2080 St Urbain, Montreal, Quebec, H2X 3X8, Canada
    Viruses 3:2146-59. 2011
    ..HAM/TSP) and has been shown to modulate host gene expression mainly through the expression of the powerful Tax transactivator, herein we were interested in looking at the potential modulation capacity of HTLV-1 Tax on HERV ..
  4. pmc Suppression of HTLV-1 replication by Tax-mediated rerouting of the p13 viral protein to nuclear speckles
    Vibeke Andresen
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD, USA
    Blood 118:1549-59. 2011
    ..HTLV-1 replication is positively regulated by Tax and Rex and negatively regulated by the p30 and HBZ proteins...
  5. pmc Human T-lymphotropic virus type 1 transcription and chromatin-remodeling complexes
    Rebecca Easley
    Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University, 2300 I St, NW, Ross Hall, Room 551, Washington, DC 20037, USA
    J Virol 84:4755-68. 2010
    Human T-lymphotropic virus type 1 (HTLV-1) encodes the viral protein Tax, which is believed to act as a viral transactivator through its interactions with a variety of transcription factors, including CREB and NF-kappaB...
  6. pmc An RNA interference screen identifies the Deubiquitinase STAMBPL1 as a critical regulator of human T-cell leukemia virus type 1 tax nuclear export and NF-κB activation
    Alfonso Lavorgna
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami, Miller School of Medicine, Miami, Florida, USA
    J Virol 86:3357-69. 2012
    The human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein actively shuttles between the nucleus, where it interacts with transcriptional and splicing regulatory proteins, and the cytoplasm, where it activates NF-κB...
  7. ncbi Dose-dependent dual effect of HTLV-1 tax oncoprotein on p53-dependent nucleotide excision repair in human T-cells
    Yana Schavinsky-Khrapunsky
    The Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences and Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Int J Cancer 122:305-16. 2008
    In this study we investigated the effect of Tax on nucleotide excision repair (NER) in human T-cell lines by using the host cell repair analysis of UVC-irradiated reporter plasmid...
  8. doi Human T-cell leukemia virus type 1 Tax modulates interferon-alpha signal transduction through competitive usage of the coactivator CBP/p300
    Jing Zhang
    Research and Development Center, Fuso Pharmaceutical Industries, Ltd, 2 3 30 Morinomiya, Joto ku, Osaka 536 8523, Japan
    Virology 379:306-13. 2008
    We describe here Tax protein of human T-cell leukemia virus type 1 (HTLV-1) as an interferon (IFN)-alpha antagonist counteracting the transactivation function of IFN-stimulated gene factor 3 (ISGF3)...
  9. doi The avidity and lytic efficiency of the CTL response to HTLV-1
    Tarek Kattan
    Department of Immunology, Wright Fleming Institute, Imperial College London, United Kingdom
    J Immunol 182:5723-9. 2009
    ..CTL quality determines the position of virus-host equilibrium in persistent HTLV-1 infection...
  10. doi Clonal expansion of HTLV-1 positive CD8+ cells relies on cIAP-2 but not on c-FLIP expression
    Linda Zane
    CNRS UMR5239, Universite de Lyon, Oncovirologie et Biothérapies, Centre Leon Berard, 69008 Lyon, France
    Virology 407:341-51. 2010
    ..lymphocyte-restricted cIAP-2 overexpression correlates with resistance to Fas-mediated apoptosis and depends on tax expression via NF-KappaB...
  11. pmc NF-κB hyper-activation by HTLV-1 tax induces cellular senescence, but can be alleviated by the viral anti-sense protein HBZ
    Huijun Zhi
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    PLoS Pathog 7:e1002025. 2011
    ..of I-κB kinases (IKKs) and NF-κB by the human T lymphotropic virus type 1 (HTLV-1) trans-activator/oncoprotein, Tax, is thought to promote cell proliferation and transformation...
  12. pmc Acetylation of the human T-cell leukemia virus type 1 Tax oncoprotein by p300 promotes activation of the NF-kappaB pathway
    Julie Lodewick
    Institute for Microbiological Research J M Wiame and Laboratory of Microbiology, Universite Libre de Bruxelles, 1, avenue Emile Gryson, B 1070 Brussels, Belgium
    Virology 386:68-78. 2009
    The oncogenic potential of the HTLV-1 Tax protein involves activation of the NF-kappaB pathway, which depends on Tax phosphorylation, ubiquitination and sumoylation...
  13. doi HTLV-1 Tax protein cooperates with Ras in protecting cells from apoptosis
    Nicola Vajente
    Department of Oncology and Surgical Sciences, Oncology Section, University of Padova, Via Gattamelata 64, 35128 Padova, Italy
    Apoptosis 14:153-63. 2009
    b>Tax protein of the human T-cell leukemia virus type 1 (HTLV-1) plays a critical role in HTLV-I-correlated diseases through its ability to deregulate the expression of a vast array of cellular genes...
  14. pmc Presentation of human T cell leukemia virus type 1 (HTLV-1) Tax protein by dendritic cells: the underlying mechanism of HTLV-1-associated neuroinflammatory disease
    Sharron L Manuel
    Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    J Leukoc Biol 86:1205-16. 2009
    ..a robust immune response including the oligoclonal expansion of CD8+ CTLs specific for the viral oncoprotein Tax. The key pathogenic process resulting in the proliferation of CTLs and the presentation of Tax peptide remains ..
  15. pmc Exclusive ubiquitination and sumoylation on overlapping lysine residues mediate NF-kappaB activation by the human T-cell leukemia virus tax oncoprotein
    Isabelle Lamsoul
    Institute for Microbiological Research J M Wiame, 1 Avenue E Gryson, B 1070 Brussels, Belgium
    Mol Cell Biol 25:10391-406. 2005
    ..which is linked to infection by human T-cell leukemia virus type 1 and the expression of its regulatory protein Tax. Although activation of the NF-kappaB pathway by Tax involves its interaction with the regulatory subunit of the ..
  16. ncbi Requirement of the human T-cell leukemia virus (HTLV-1) tax-stimulated HIAP-1 gene for the survival of transformed lymphocytes
    Katja Wäldele
    Institut fur Klinische und Molekulare Virologie, Universitat Erlangen Nurnberg, Schlossgarten 4, D 91054 Erlangen, Germany
    Blood 107:4491-9. 2006
    ..a consistent phenotype of HTLV-1-transformed and ATL-derived cultures and its stimulation by the viral oncoprotein Tax. Cotransfections revealed a 60-fold increase of HIAP-1 promoter activity mediated by Tax mainly via nuclear factor-..
  17. pmc Modulation of dendritic cell maturation and function by the Tax protein of human T cell leukemia virus type 1
    Pooja Jain
    Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    J Leukoc Biol 82:44-56. 2007
    ..characterized by the generation of an intense CTL cell response directed against the viral transactivator protein Tax. In addition, patients diagnosed with HAM/TSP exhibit rapid activation and maturation of dendritic cells (DC), ..
  18. doi Functional interaction of HTLV-1 tax protein with the POZ domain of the transcriptional repressor BCL6
    J Dean
    UCD Centre for Research in Infectious Diseases, School of Medicine and Medical Science, University College Dublin, Dublin, Ireland
    Oncogene 28:3723-34. 2009
    The Tax protein encoded by human T-cell leukaemia virus type 1 (HTLV-1) has a pivotal role in T-cell transformation by deregulating cellular signalling pathways...
  19. doi MicroRNA miR-146a is induced by HTLV-1 tax and increases the growth of HTLV-1-infected T-cells
    Mariko Tomita
    University of the Ryukyus, Nishihara, Okinawa, Japan
    Int J Cancer 130:2300-9. 2012
    ..b>Tax-induced miR-146a expression in a NF-κB-dependent manner and inhibited the expression of gene harboring the target ..
  20. pmc The human T-cell leukemia virus type 1 oncoprotein tax controls forkhead box O4 activity through degradation by the proteasome
    Alexandra Oteiza
    CNRS UMR 5236, Centre d Études d Agents Pathogènes et Biotechnologie pour la Santé CPBS, 1919 Route de Mende, 34 293 Montpellier Cedex 5, France
    J Virol 85:6480-91. 2011
    Activation of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway by the viral Tax oncoprotein plays a pivotal role in clonal expansion of human T-cell leukemia virus type 1 (HTLV-1)-infected cells...
  21. pmc Localization and sub-cellular shuttling of HTLV-1 tax with the miRNA machinery
    Rachel Van Duyne
    Department of Molecular and Microbiology, National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, Virginia, United States of America
    PLoS ONE 7:e40662. 2012
    ..Here, we show that HTLV-1 Tax contributes to the dysregulation of the RNAi pathway by altering the expression of key components of this pathway...
  22. doi The tumor marker Fascin is strongly induced by the Tax oncoprotein of HTLV-1 through NF-kappaB signals
    Andrea K Kress
    Institute of Clinical and Molecular Virology, Friedrich Alexander Universitat Erlangen Nurnberg, Schlossgarten 4, Erlangen, Germany
    Blood 117:3609-12. 2011
    ..T-cell leukemia/lymphoma, a process that is mainly initiated by perturbation of cellular signaling by the viral Tax oncoprotein, a potent transcriptional regulator...
  23. pmc Tax interacts with P-TEFb in a novel manner to stimulate human T-lymphotropic virus type 1 transcription
    Meisheng Zhou
    Virus Tumor Biology Section, Laboratory of Cellular Oncology, Center for Cancer Research, NCI NIH, Bethesda, MD 20892, USA
    J Virol 80:4781-91. 2006
    Human T-lymphotropic virus type 1 (HTLV-1) encodes a transcriptional activator, Tax, whose function is essential for viral transcription and replication...
  24. ncbi Molecular characterization of the Tax-containing HTLV-1 enhancer complex reveals a prominent role for CREB phosphorylation in Tax transactivation
    Young Mi Kim
    Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado 80523 1870, USA
    J Biol Chem 282:18750-7. 2007
    Transcriptional activation of human T-cell leukemia virus type 1 (HTLV-1) is mediated by the viral oncoprotein Tax, which utilizes cellular transcriptional machinery to perform this function...
  25. pmc In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor
    K T Jeang
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    J Virol 67:6224-33. 1993
    ..These experiments extend previous genetic experiments and suggest a direct interaction between Tat and Sp1 during transactivation...
  26. ncbi Interaction of HTLV-1 Tax and methyl-CpG-binding domain 2 positively regulates the gene expression from the hypermethylated LTR
    Takeshi Ego
    Department of Viral Oncology, Institute for Virus Research, Kyoto University, 53 Kawara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Oncogene 24:1914-23. 2005
    ..Gene expression of human T-cell leukemia virus type 1 (HTLV-1) is regulated by a viral transcriptional stimulator, Tax. We herein report a novel mechanism of transcription from the HTLV-1 long terminal repeat (LTR) that is regulated ..
  27. pmc HTLV-1 Tax transgenic mice develop spontaneous osteolytic bone metastases prevented by osteoclast inhibition
    Ling Gao
    Department of Medicine, Division of Oncology, Washington University School of Medicine, 660 S Euclid Ave, Box 8069, St Louis, MO 63110, USA
    Blood 106:4294-302. 2005
    ..Overexpression of the HTLV-1-encoded Tax oncoprotein under the human granzyme B promoter causes large granular lymphocytic leukemia/lymphomas in mice...
  28. pmc Human T-cell leukemia virus type 1 Tax protein down-regulates pre-T-cell receptor alpha gene transcription in human immature thymocytes
    Melanie Wencker
    Virologie Humaine U758, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
    J Virol 81:301-8. 2007
    ..Here we show that the regulatory protein Tax of the human T-cell leukemia virus type 1 (HTLV-1) efficiently suppresses the E47-mediated activation of the ..
  29. pmc Evidence for cooperative transforming activity of the human pituitary tumor transforming gene and human T-cell leukemia virus type 1 Tax
    Sergey V Sheleg
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Virol 81:7894-901. 2007
    ..Here, we report that overexpression of human PTTG cooperated with the HTLV-I Tax oncoprotein in cellular transformation...
  30. pmc Modulation of the Brd4/P-TEFb interaction by the human T-lymphotropic virus type 1 tax protein
    Won Kyung Cho
    Virus Tumor Biology Section, Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 41 Medlars Dr, Bldg 41, Rm B201, Bethesda, MD 20892, USA
    J Virol 81:11179-86. 2007
    ..Our lab has recently demonstrated that P-TEFb is required for Tax transactivation of the viral long terminal repeat (LTR)...
  31. pmc Molecular characterization of HTLV-1 Tax interaction with the KIX domain of CBP/p300
    Julita A Ramírez
    Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523 1870, USA
    J Mol Biol 372:958-69. 2007
    The viral oncoprotein Tax mediates transcriptional activation of human T-cell leukemia virus type 1 (HTLV-1)...
  32. pmc Cross talk between expression of the human T-cell leukemia virus type 1 Tax transactivator and the oncogenic bHLH transcription factor TAL1
    Jean Michel Terme
    Laboratoire de Biologie Moleculaire de la Cellule, UMR5239 CNRS ENS de Lyon, IFR 128 Biosciences Lyon Gerland, 46 allee d Italie, 69364 Lyon Cedex 07, France
    J Virol 82:7913-22. 2008
    The human T-cell leukemia virus type 1 (HTLV-1) Tax transactivator is known to induce or repress various cellular genes, several of them encoding transcription factors...
  33. pmc Human T-cell leukemia virus type 1 Tax relieves repression of proliferating cell nuclear antigen gene expression
    Dustin C Edwards
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, MS 385, One Baylor Plaza, Houston, TX 77030, USA
    J Virol 82:11714-22. 2008
    ..The transforming ability of Tax, the viral oncoprotein, is believed to depend on interactions with cell cycle regulators and on transactivation of ..
  34. pmc Induction of galectin-1 expression by HTLV-I Tax and its impact on HTLV-I infectivity
    Sonia Gauthier
    Universite du Quebec a Montreal, Departement des Sciences Biologiques, 2080 St Urbain, Montreal, Quebec, H2X 3X8, Canada
    Retrovirology 5:105. 2008
    ..Several functions have been attributed to this protein including its capacity to increase cell-to-cell adhesion. Based on previous studies, we postulated that this protein could also accentuate HTLV-I infection...
  35. pmc Peptidylproline cis-trans-isomerase Pin1 interacts with human T-cell leukemia virus type 1 tax and modulates its activation of NF-kappaB
    Jean Marie Peloponese
    Molecular Virology Section, Laboratory of Molecular, Microbiology, The National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, Maryland 20892 0460, USA
    J Virol 83:3238-48. 2009
    ..The virus encodes a Tax oncoprotein that functions in transcriptional regulation, cell cycle control, and transformation...
  36. pmc Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein
    S S Lee
    Division of Molecular Virology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 94:6670-5. 1997
    ..Human T cell leukemia virus type 1 Tax and most oncogenic human papillomavirus E6 oncoproteins also possessed PDZ domain-binding motifs at their C termini ..
  37. ncbi Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1
    D Y Jin
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892 0460, USA
    Cell 93:81-91. 1998
    In searching for cellular targets of the HTLV-I oncoprotein Tax, we identified TXBP181, which we characterized as the human homolog of yeast mitotic checkpoint MAD1 protein...
  38. pmc Physical interaction of human T-cell leukemia virus type 1 Tax with cyclin-dependent kinase 4 stimulates the phosphorylation of retinoblastoma protein
    Kerstin Haller
    Institut fur Klinische und Molekulare Virologie, D 91054 Erlangen, Germany
    Mol Cell Biol 22:3327-38. 2002
    The Tax oncoprotein of human T-cell leukemia virus type 1 (HTLV-1) induces leukemia in transgenic mice and permanent T-cell growth in vitro. In transformed lymphocytes, it acts as an essential growth factor...
  39. ncbi Stimulation of IKK-gamma oligomerization by the human T-cell leukemia virus oncoprotein Tax
    Guo Jin Huang
    National Key Laboratory for Molecular Virology, Institute of Virology, 100 Yingxin Street, 100052, Beijing, PR China
    FEBS Lett 531:494-8. 2002
    Human T-cell leukemia virus type 1 oncoprotein Tax activates NF-kappaB through direct binding to IKK-gamma, the regulatory component of the IkappaB kinase complex...
  40. ncbi Protein profile of tax-associated complexes
    Kaili Wu
    Department of Biochemistry and Molecular Biology, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA
    J Biol Chem 279:495-508. 2004
    ..b>Tax, a 40-kDa protein, regulates viral and cellular transcription, host signal transduction, the cell cycle, and ..
  41. ncbi Setting the stage for transformation: HTLV-1 Tax inhibition of p53 function
    Cynthia A Pise-Masison
    Virus Tumor Biology Section, Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 41 Room B201, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Front Biosci 10:919-30. 2005
    ..the pathogenesis has been linked to the pleiotropic activity of the viral transcriptional activator protein Tax. Tax has been shown to regulate viral and cellular gene expression and to functionally interfere with proteins ..
  42. ncbi The HTLV-I Tax oncoprotein targets the retinoblastoma protein for proteasomal degradation
    Kylene Kehn
    Department of Biochemistry and Molecular Biology, The George Washington University School of Medicine, Washington, DC 20037, USA
    Oncogene 24:525-40. 2005
    ..The transforming ability of HTLV-I has been largely attributed to the viral protein Tax, which modulates the activity of several well-known cell cycle regulators...
  43. pmc HTLV-I Tax directly binds the Cdc20-associated anaphase-promoting complex and activates it ahead of schedule
    Baoying Liu
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Proc Natl Acad Sci U S A 102:63-8. 2005
    Expression of the human T lymphotropic virus type I (HTLV-I) transactivator/oncoprotein, Tax, leads to faulty mitosis as reflected by chromosome aneuploidy, cytokinesis failure, and formation of micro- and multinucleated cells...
  44. ncbi Secretion of the human T cell leukemia virus type I transactivator protein tax
    Timothy Alefantis
    Department of Microbiology and Immunology, Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 280:17353-62. 2005
    ..The HTLV-I protein Tax is well known as a transcriptional transactivator and inducer of cellular transformation...
  45. ncbi Human T cell leukemia virus type I Tax activates CD40 gene expression via the NF-kappa B pathway
    Edward W Harhaj
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami School of Medicine, Miami, FL 33136, USA
    Virology 333:145-58. 2005
    ..In this study, we demonstrate that HTLV-I Tax induces the aberrant expression of CD40, a member of the tumor necrosis factor receptor (TNFR) family that plays an ..
  46. pmc Ku protein as a potential human T-cell leukemia virus type 1 (HTLV-1) Tax target in clastogenic chromosomal instability of mammalian cells
    Franca Majone
    Department of Biology, University of Padua, Padua, Italy
    Retrovirology 2:45. 2005
    The HTLV-1 Tax oncoprotein rapidly induces cytogenetic damage which can be measured by a significant increase in the number of micronuclei (MN) in cells. Tax is thought to have both aneuploidogenic and clastogenic effects...
  47. ncbi Human T cell leukemia virus type 1: the role of Tax in leukemogenesis
    Cynthia A Pise-Masison
    Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 5055, USA
    Arch Immunol Ther Exp (Warsz) 53:283-96. 2005
    ..the pathogenesis has been linked to the pleiotropic activity of the viral transcriptional activator protein Tax. Tax has been shown to regulate viral and cellular gene expression and to functionally interfere with proteins ..
  48. ncbi Lethal cutaneous disease in transgenic mice conditionally expressing type I human T cell leukemia virus Tax
    Hakju Kwon
    Gladstone Institute of Virology and Immunology, San Francisco, California 94158, USA
    J Biol Chem 280:35713-22. 2005
    ..T cell transformation induced by HTLV-I involves the action of the 40-kDa viral Tax transactivator protein...
  49. ncbi HTLV-1 Tax nucleocytoplasmic shuttling, interaction with the secretory pathway, extracellular signaling, and implications for neurologic disease
    Timothy Alefantis
    Vital Probes, Inc, 1300 Old Plank Road, Mayfield, PA 18433, USA
    J Biomed Sci 12:961-74. 2005
    The human T cell leukemia virus type 1 (HTLV-1) oncoprotein Tax interacts with numerous cellular pathways promoting both the survival and pathogenesis of the virus in the human population...
  50. pmc SUV39H1 interacts with HTLV-1 Tax and abrogates Tax transactivation of HTLV-1 LTR
    Koju Kamoi
    Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 4 6 1 Shirokanedai, Tokyo 108 8639, Japan
    Retrovirology 3:5. 2006
    b>Tax is the oncoprotein of HTLV-1 which deregulates signal transduction pathways, transcription of genes and cell cycle regulation of host cells...
  51. ncbi Human T-cell leukemia virus type-I oncoprotein Tax inhibits Fas-mediated apoptosis by inducing cellular FLIP through activation of NF-kappaB
    Kazuo Okamoto
    Graduate School of Biostudies, Kyoto University, Kyoto 606 8507, Japan
    Genes Cells 11:177-91. 2006
    ..Previous analyses of tax transgenic mice suggested that protection of peripheral T-cells from Fas-mediated apoptosis by virus-encoded ..
  52. ncbi Tax-dependent displacement of nucleosomes during transcriptional activation of human T-cell leukemia virus type 1
    Isabelle Lemasson
    Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado 80523 1870, USA
    J Biol Chem 281:13075-82. 2006
    ..Within the repressive chromatin environment, the virally encoded Tax protein mediates the recruitment of the coactivators CREB-binding protein/p300 to the HTLV-1 promoter, located ..
  53. ncbi Site-specific phosphorylation differentiates active from inactive forms of the human T-cell leukemia virus type 1 Tax oncoprotein
    Sarah S Durkin
    Department of Microbiology and Molecular Cell Biology, Center for Biomedical Proteomics, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    J Biol Chem 281:31705-12. 2006
    The human T-cell leukemia virus type 1 oncoprotein Tax is a phosphoprotein with a predominately nuclear subcellular localization that accomplishes multiple functions via protein-protein interactions...
  54. pmc Human T-cell leukemia virus type-1 Tax oncoprotein regulates G-protein signaling
    Jean Claude Twizere
    Department of Cellular and Molecular Biology, Faculty of Gembloux, Belgium
    Blood 109:1051-60. 2007
    ..HTLV-1 encodes the oncoprotein Tax-1, which modulates viral and cellular gene expression leading to T-cell transformation...
  55. pmc Coactivator-associated arginine methyltransferase 1 enhances transcriptional activity of the human T-cell lymphotropic virus type 1 long terminal repeat through direct interaction with Tax
    Soo Jin Jeong
    Virus Tumor Biology Section, Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 41 Medlars Drive, Building 41, Room B302, Bethesda, MD 20892, USA
    J Virol 80:10036-44. 2006
    ..which methylates histone H3 and other proteins such as p300/CBP, is positively involved in the regulation of Tax transactivation...
  56. pmc Inactivation of tumor suppressor Dlg1 augments transformation of a T-cell line induced by human T-cell leukemia virus type 1 Tax protein
    Kojiro Ishioka
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata, Japan
    Retrovirology 3:71. 2006
    ..The interaction of human T-cell leukemia virus type 1 (HTLV-1) Tax1 protein with the tumor suppressor Dlg1 is correlated with cellular transformation...
  57. ncbi Regulation of the human T-cell leukemia virus gene expression depends on the localization of regulatory proteins Tax, Rex and p30II in specific nuclear subdomains
    Hicham Baydoun
    Institute for Microbiological Research J M Wiame and Laboratory of Microbiology, University of Brussels, Belgium
    Gene 386:191-201. 2007
    The human T-cell leukemia virus HTLV-1 encodes regulatory proteins, Tax, Rex and p30(II), which are involved in the control of viral gene expression at the transcriptional and post-transcriptional levels...
  58. ncbi Activation of NF-kappa B by the human T cell leukemia virus type I Tax oncoprotein is associated with ubiquitin-dependent relocalization of I kappa B kinase
    Nicole S Harhaj
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami, Miller School of Medicine, Miami, Florida 33136, USA
    J Biol Chem 282:4185-92. 2007
    ..HTLV-1 encodes a trans-activating protein, Tax, which is largely responsible for the oncogenic properties of the virus...
  59. ncbi Heptad repeats regulate protein phosphatase 2a recruitment to I-kappaB kinase gamma/NF-kappaB essential modulator and are targeted by human T-lymphotropic virus type 1 tax
    Sohee Hong
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Biol Chem 282:12119-26. 2007
    ..HTLV-1 transactivator Tax also binds HLX2, and this interaction is enhanced by CCR2 but reduced by LZ...
  60. pmc Retroviral oncoprotein Tax deregulates NF-kappaB by activating Tak1 and mediating the physical association of Tak1-IKK
    Xuefeng Wu
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey Medical Center, PO Box 850, Hershey, Pennsylvania 17033, USA
    EMBO Rep 8:510-5. 2007
    The Tax oncoprotein of human T-cell leukaemia virus type I (HTLV-I) persistently activates nuclear factor-kappaB (NF-kappaB), which is required for HTLV-I-mediated T-cell transformation...
  61. pmc Human T-cell leukemia virus type 1 Tax enhances serum response factor DNA binding and alters site selection
    Heather Y Winter
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Virol 81:6089-98. 2007
    ..The viral transforming protein Tax regulates the transcription of viral and cellular genes by interacting with cellular transcription factors and ..
  62. pmc HTLV-1 Tax mutants that do not induce G1 arrest are disabled in activating the anaphase promoting complex
    Randall Merling
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Retrovirology 4:35. 2007
    HTLV-1 Tax is a potent activator of viral transcription and NF-kappaB...
  63. ncbi Human T-cell leukemia virus type 1 Tax oncoprotein prevents DNA damage-induced chromatin egress of hyperphosphorylated Chk2
    Saurabh K Gupta
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    J Biol Chem 282:29431-40. 2007
    De novo expression of human T-cell leukemia virus type 1 Tax results in cellular genomic instability...
  64. ncbi The PDZ domain-binding motif of the human T cell leukemia virus type 1 tax protein induces mislocalization of the tumor suppressor hScrib in T cells
    Charlotte Arpin-André
    Centre d Etudes d Agents Pathogenes et Biotechnologies pour la Sante, Centre National de la Recherche Scientifique UM 1 UM 2 UMR 5236 IFR 122, Institut de Biologie, 4 Boulevard Henri IV, Montpellier Cedex 2, France
    J Biol Chem 282:33132-41. 2007
    ..In this regard, the oncogenic potential of the human T cell leukemia virus type 1 Tax protein correlates with its binding capacity to the tumor suppressor hDlg...
  65. ncbi Human T-cell leukemia virus type 1 Tax and cellular transformation
    Jean Marie Peloponese
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
    Int J Hematol 86:101-6. 2007
    ..ATL is characterized by abnormal lymphocytes, called flower cells, which have cleaved and convoluted nuclei. Tax, encoded by the HTLV-1 pX region, is a critical nonstructural protein that plays a central role in leukemogenesis; ..
  66. ncbi Ubiquitylated Tax targets and binds the IKK signalosome at the centrosome
    Y Kfoury
    Department of Internal Medicine, American University of Beirut, Beirut, Lebanon
    Oncogene 27:1665-76. 2008
    Constitutive activation of the NF-kappaB pathway by the Tax oncoprotein plays a crucial role in the proliferation and transformation of HTLV-I infected T lymphocytes...
  67. pmc The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation
    Noula Shembade
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami, Miller School of Medicine, 1550 NW 10 Avenue, Miami, FL 33136, USA
    J Virol 81:13735-42. 2007
    Ubiquitination of the human T-cell leukemia virus 1 Tax oncoprotein provides an important regulatory mechanism that promotes the Tax-mediated activation of NF-kappaB...
  68. pmc The human T-cell leukemia virus type 1 tax protein confers CBP/p300 recruitment and transcriptional activation properties to phosphorylated CREB
    Timothy R Geiger
    Department of Biochemistry and Molecular Biology, Campus Box 1870, Colorado State University, Fort Collins, CO 80523 1870, USA
    Mol Cell Biol 28:1383-92. 2008
    The human T-cell leukemia virus-encoded oncoprotein Tax is a potent activator of viral transcription...
  69. ncbi Tax-inducible production of CC chemokine ligand 22 by human T cell leukemia virus type 1 (HTLV-1)-infected T cells promotes preferential transmission of HTLV-1 to CCR4-expressing CD4+ T cells
    Kunio Hieshima
    Department of Microbiology, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    J Immunol 180:931-9. 2008
    ..In terms of gene expression and protein secretion, we found a strong correlation between HTLV-1 Tax oncoprotein and CCL22, a CCR4 ligand, in HTLV-1-infected T cells...
  70. pmc Human T Lymphotropic Virus Type 1 protein Tax reduces histone levels
    James M Bogenberger
    Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado, USA
    Retrovirology 5:9. 2008
    ..The virally encoded Tax protein is thought to be necessary and sufficient for T-cell leukemogenesis...
  71. doi Strong induction of 4-1BB, a growth and survival promoting costimulatory receptor, in HTLV-1-infected cultured and patients' T cells by the viral Tax oncoprotein
    Klemens Pichler
    Institute of Clinical and Molecular Virology, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    Blood 111:4741-51. 2008
    ..of costimulatory receptors, while the growth-stimulating HTLV-1 functions are mediated by the viral oncoprotein Tax. Here we analyzed the impact of Tax on costimulatory receptors in T cells with repressible Tax and found that among ..
  72. pmc Human T-cell leukemia virus type 1 oncoprotein tax represses ZNF268 expression through the cAMP-responsive element-binding protein/activating transcription factor pathway
    Di Wang
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
    J Biol Chem 283:16299-308. 2008
    Expression of the human T-cell leukemia virus type 1 (HTLV-1) oncoprotein Tax is correlated with cellular transformation, contributing to the development of adult T-cell leukemia...
  73. pmc Human T-cell leukemia virus type 1 tax attenuates the ATM-mediated cellular DNA damage response
    Chandtip Chandhasin
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Virol 82:6952-61. 2008
    ..type 1 (HTLV-1), is associated with extensive genomic instability that has been attributed to the viral oncoprotein Tax. How Tax influences cellular responses to DNA damage to mediate genomic instability, however, remains unclear...
  74. pmc HTLV-1 Tax oncoprotein subverts the cellular DNA damage response via binding to DNA-dependent protein kinase
    Sarah S Durkin
    Department of Microbiology and Molecular Cell Biology, Center for Biomedical Proteomics, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    J Biol Chem 283:36311-20. 2008
    ..Previous research has established that the viral oncoprotein Tax mediates the transformation process by impairing cell cycle control and cellular response to DNA damage...
  75. pmc MicroRNA miR-146a and further oncogenesis-related cellular microRNAs are dysregulated in HTLV-1-transformed T lymphocytes
    Klemens Pichler
    Institute of Clinical and Molecular Virology, University Erlangen Nuremberg, Schlossgarten 4, Erlangen, Germany
    Retrovirology 5:100. 2008
    ..Transformation of infected cells involves HTLV-1's oncoprotein Tax, which perturbs cell cycle regulation and modulates cellular gene expression...
  76. pmc Dimerization and a novel Tax speckled structure localization signal are required for Tax nuclear localization
    Kimberly A Fryrear
    Department of Microbiology and Molecular Cell Biology, Norfolk, VA 23507, USA
    J Virol 83:5339-52. 2009
    The human T-cell leukemia virus type 1 oncoprotein Tax has pleiotropic activities, a subset of which likely leads to immortalization of T cells. Tax is expressed and known to function in both the cell nucleus and the cytoplasm...
  77. doi The prolyl isomerase Pin1 stabilizes the human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein and promotes malignant transformation
    Soo Jin Jeong
    AIDS Research Center, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Biochem Biophys Res Commun 381:294-9. 2009
    The HTLV Tax protein is crucial for viral replication and malignant transformation. We investigated the possible role of peptidyl prolyl isomerase Pin1 in the positive regulation of the human T-cell leukemia virus type 1 Tax...
  78. pmc Induction of p21(CIP1/WAF1) expression by human T-lymphotropic virus type 1 Tax requires transcriptional activation and mRNA stabilization
    Ling Zhang
    Department of Microbiology and Immunology, Uniformed Services University, Bethesda, MD 20814, USA
    Retrovirology 6:35. 2009
    HTLV-1 Tax can induce senescence by up-regulating the levels of cyclin-dependent kinase inhibitors p21(CIP1/WAF1) and p27(KIP1)...
  79. doi HTLV-1-Tax and ICAM-1 act on T-cell signal pathways to polarize the microtubule-organizing center at the virological synapse
    Mohamed Nejmeddine
    Department of Immunology, Wright Fleming Institute, Imperial College, Norfolk Pl, London W2 1PG London, United Kingdom
    Blood 114:1016-25. 2009
    ..We previously demonstrated that the combination of intracellular Tax protein expression and the stimulation of the intercellular adhesion molecule-1 (ICAM-1) on the cell surface is ..
  80. pmc Identification of a novel motif responsible for the distinctive transforming activity of human T-cell leukemia virus (HTLV) type 1 Tax1 protein from HTLV-2 Tax2
    Toshiyuki Shoji
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Retrovirology 6:83. 2009
    ..This distinction was mediated by at least two Tax1 specific functions, an interaction with host cellular factors through the PDZ domain binding motif (PBM) and the activation of NF-kappa B2 (NF-kappa B2)/p100...
  81. pmc Distinct functions of HTLV-1 Tax1 from HTLV-2 Tax2 contribute key roles to viral pathogenesis
    Masaya Higuchi
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Retrovirology 6:117. 2009
    ..In this review, we summarize the functions of Tax1 associated with cell survival, cell proliferation, persistent infection as well as pathogenesis. We emphasize special attention to distinctions between Tax1 and Tax2...
  82. pmc HTLV-I Tax-dependent and -independent events associated with immortalization of human primary T lymphocytes
    Marcia Bellon
    University of Kansas Medical Center, Department of Pathology and Laboratory Medicine, Center for Viral Oncology, KU Cancer Center, Kansas City, KS 66160, USA
    Blood 115:2441-8. 2010
    ..Although in vitro immortalization by HTLV-I virus is very efficient, we report that Tax has poor oncogenic activity in human primary T cells and that immortalization by Tax is rare...
  83. pmc Induction of reactive oxygen species by human T-cell leukemia virus type 1 tax correlates with DNA damage and expression of cellular senescence marker
    Takao Kinjo
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 84:5431-7. 2010
    Human T-cell leukemia virus type 1 (HTLV-1) Tax affects cellular genomic stability and senescence. As yet, the mechanism(s) for these events caused by Tax is incompletely understood...
  84. doi The pleiotropic protein kinase CK2 phosphorylates HTLV-1 Tax protein in vitro, targeting its PDZ-binding motif
    Carlo Bidoia
    Department of Life and Reproduction Sciences, Section of Biology and Genetics, University of Verona, Strada Le Grazie 8, Verona, Italy
    Virus Genes 41:149-57. 2010
    The HTLV-1 transactivator Tax is an oncoprotein capable of deregulating the expression of many cellular genes and interfering with signalling pathways...
  85. pmc Molecular determinants of PDLIM2 in suppressing HTLV-I Tax-mediated tumorigenesis
    J Fu
    University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Oncogene 29:6499-507. 2010
    Human T-cell leukemia virus type I (HTLV-I) encodes a Tax oncoprotein that has crucial roles in both virus replication and cell transformation...
  86. doi Association of HTLV Tax proteins with TAK1-binding protein 2 and RelA in calreticulin-containing cytoplasmic structures participates in Tax-mediated NF-κB activation
    Francesca Avesani
    Department of Life and Reproduction Sciences, Section of Biology and Genetics, University of Verona, Strada Le Grazie 8, Verona, Italy
    Virology 408:39-48. 2010
    ..Both Tax-1 protein from HTLV-1 and Tax-2 from HTLV-2 activate the NF-κB pathway...
  87. doi Human T-cell leukemia virus type 1 tax transactivates the matrix metalloproteinase 7 gene via JunD/AP-1 signaling
    Sawako Nakachi
    Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Biochim Biophys Acta 1813:731-41. 2011
    ..was induced following infection of a human T-cell line with HTLV-1, and specifically by the viral protein Tax. Functionally, MMP-7 promoted cell migration of HTLV-1-infected T cells...
  88. pmc Ubiquitin-specific peptidase 20 targets TRAF6 and human T cell leukemia virus type 1 tax to negatively regulate NF-kappaB signaling
    Junichiro Yasunaga
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 85:6212-9. 2011
    ..The HTLV-1 viral oncoprotein Tax functions pivotally in leukemogenesis through its potent activation of NF-κB...
  89. pmc The HTLV-1 Tax oncoprotein represses Ku80 gene expression
    Razvan I Ducu
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Virology 416:1-8. 2011
    The HTLV-I oncoprotein Tax interferes with DNA double strand break repair...
  90. pmc Intracellular localization and cellular factors interaction of HTLV-1 and HTLV-2 Tax proteins: similarities and functional differences
    Umberto Bertazzoni
    Department of Life and Reproduction Sciences, University of Verona, Strada Le Grazie 8, 37134, Verona, Italy
    Viruses 3:541-60. 2011
    ..Is this difference due to their transactivating Tax proteins, Tax-1 and Tax-2, which are responsible for viral and cellular gene activation? Do Tax-1 and Tax-2 differ ..
  91. doi Activation of mTOR by human T-cell leukemia virus type 1 Tax is important for the transformation of mouse T cells to interleukin-2-independent growth
    Manami Yoshita
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Cancer Sci 103:369-74. 2012
    ..HTLV-1 encodes Tax, which plays crucial roles in HTLV-1-mediated immortalization and transformation of human T cells...
  92. pmc The Sumo-targeted ubiquitin ligase RNF4 regulates the localization and function of the HTLV-1 oncoprotein Tax
    Kimberly A Fryrear
    Department of Microbiology and Molecular Cell Biology, The Leroy T Canoles Jr Cancer Research Center, Eastern Virginia Medical School, Norfolk, VA 23508, USA
    Blood 119:1173-81. 2012
    ..In the present study, we show that the Human T-cell Leukemia Virus Type 1 (HTLV-1) oncoprotein Tax is a substrate for RNF4 both in vivo and in vitro...
  93. pmc HTLV-I tax increases genetic instability by inducing DNA double strand breaks during DNA replication and switching repair to NHEJ
    Hicham H Baydoun
    University of Kansas Medical Center, Department of Pathology and Laboratory Medicine, Kansas City, Kansas, USA
    PLoS ONE 7:e42226. 2012
    ..Although HTLV-I-transformed leukemic cells have numerous genetic lesions, the precise role of the viral tax gene in this process is not fully understood.
  94. pmc NF-kappaB activation: Tax sumoylation is out, but what about Tax ubiquitination?
    Gutian Xiao
    University of Pittsburgh Cancer Institute, University of Pittsburgh Medical Centers, Pittsburgh, PA 15213, USA
    Retrovirology 9:78. 2012
    Activation of the NF-κB transcription factors by the viral protein Tax plays a vital role in the pathogenesis of diseases associated with human T-cell lymphotropic virus type I (HTLV-I)...
  95. doi Human T cell leukemia virus type 2 (HTLV-2) Tax2 has a dominant activity over HTLV-1 Tax1 to immortalize human CD4+ T cells
    Michitaka Imai
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata, Japan
    Virus Genes 46:39-46. 2013
    ..The distinct T cell immortalization activities of Tax2 and Tax1 might therefore play a role in the different pathogeneses observed for these two viruses...
  96. pmc LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription
    Hei Man Vincent Tang
    Department of Biochemistry, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong
    Retrovirology 10:40. 2013
    ..Treatment options are limited and prophylactic agents are not available. We have previously demonstrated an essential role for CREB-regulating transcriptional coactivators (CRTCs) in HTLV-1 transcription...
  97. doi Human T-cell leukemia virus type 1 Tax induces an aberrant clustering of the tumor suppressor Scribble through the PDZ domain-binding motif dependent and independent interaction
    Masaaki Okajima
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata, 951 8510, Japan
    Virus Genes 37:231-40. 2008
    ..These results suggest that Tax1 through two binding sites induce aberrant clustering of Scribble, thereby altering the functions in HTLV-1-infected cells, which may thus play a role in persistent HTLV-1 infection and the pathogenesis...
  98. ncbi Interaction of retroviral Tax oncoproteins with tristetraprolin and regulation of tumor necrosis factor-alpha expression
    Jean Claude Twizere
    Biologie Cellulaire et Moleculaire, Faculté universitaire des Sciences agronomiques, Gembloux, Belgium
    J Natl Cancer Inst 95:1846-59. 2003
    The Tax oncoproteins are transcriptional regulators of viral expression involved in pathogenesis induced by complex leukemogenic retroviruses (or delta-retroviruses, i.e., primate T-cell leukemia viruses and bovine leukemia virus)...
  99. ncbi Enhanced activation of tax-dependent transcription of human T-cell leukemia virus type I (HTLV-I) long terminal repeat by TORC3
    Hiroshi Koga
    Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    J Biol Chem 279:52978-83. 2004
    b>Tax, a protein encoded by the env-pX gene of human T-cell leukemia virus type I (HTLV-I), interacts with various host cell transcription factors...
  100. pmc Resistance to Apo2 ligand (Apo2L)/tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis and constitutive expression of Apo2L/TRAIL in human T-cell leukemia virus type 1-infected T-cell lines
    Takehiro Matsuda
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    J Virol 79:1367-78. 2005
    ..Inducible expression of the viral oncoprotein Tax in a T-cell line up-regulated Apo2L mRNA...
  101. pmc Abnormal centrosome amplification in cells through the targeting of Ran-binding protein-1 by the human T cell leukemia virus type-1 Tax oncoprotein
    Jean Marie Peloponese
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0460, USA
    Proc Natl Acad Sci U S A 102:18974-9. 2005
    ..The virus encodes a Tax oncoprotein that functions in transcriptional regulation, cell cycle control, and transformation...

Research Grants3

  1. Regulation of HTLV-I replication by the viral p30
    Christophe Nicot; Fiscal Year: 2009
    ..We have recently found that HTLV-I has evolved a protein, p30, that interacts specifically with the tax/rex viral RNA encoding positive regulators of virus expression...
  2. HTLV deregulation of NF-kappaB2 p100 processing in tumor
    Gutian Xiao; Fiscal Year: 2010
    ..b>Tax, an oncoprotein encoded by human T-cell leukemia virus type I (HTLV- I), the etiological agent of adult T-cell ..
  3. HTLV Deregulation of CD40(L) in Cancer&Neurodegeneration
    Edward Harhaj; Fiscal Year: 2007
    ..proliferation and CD40L expression in HTLV-l-infected T lymphocytes; (3) the effects of HTLV-I and HTLV-I Tax on the transcriptional regulation of CD40L; and (4) the impact of deregulated expression of CD40 and CD40L on the ..