TCN1

Summary

Gene Symbol: TCN1
Description: transcobalamin 1
Alias: TC-1, TC1, TCI, transcobalamin-1, haptocorin, haptocorrin, protein R, transcobalamin I (vitamin B12 binding protein, R binder family)
Species: human

Top Publications

  1. ncbi Heteronuclear NMR studies of cobalt corrinoids. 20. 31P chemical shift anisotropy of aquacobalamin and its complex with a haptocorrin from chicken serum
    K L Brown
    Department of Chemistry, Clippinger Laboratory, Ohio University, Athens 45701, USA
    J Inorg Biochem 71:199-204. 1998
  2. ncbi Haptocorrin in humans
    Anne L Morkbak
    Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
    Clin Chem Lab Med 45:1751-9. 2007
  3. doi Low fresh gas flow balanced anesthesia versus target controlled intravenous infusion anesthesia in laparoscopic cholecystectomy: a cost-minimization analysis
    Predrag D Stevanovic
    Clinic of Anaesthesiology and Reanimatology, Clinical Center Dr D Misovic DEDINJE, University of Belgrade, Belgrade, Republic of Serbia
    Clin Ther 30:1714-25. 2008
  4. doi Effect of temperature on thermal acclimation in growing pigs estimated using a nonlinear function
    D Renaudeau
    INRA UR143 Unité de Recherches Zootechniques, Petit Bourg, Guadeloupe, France
    J Anim Sci 88:3715-24. 2010
  5. pmc Chagas cardiomyopathy manifestations and Trypanosoma cruzi genotypes circulating in chronic Chagasic patients
    Juan David Ramírez
    Centro de investigaciones en Microbiología y Parasitología Tropical CIMPAT, Facultad de Ciencias, Departamento de Ciencias Biologicas, Universidad de Los Andes, Bogota, Colombia
    PLoS Negl Trop Dis 4:e899. 2010
  6. pmc Association of IL-1 RN*2 allele and methionine synthase 2756 AA genotype with dementia severity of sporadic Alzheimer's disease
    P Bosco
    IRCCS Associazione Oasi Maria SS, Institute for Research on Mental Retardation and Brain Aging, Troina, Italy
    J Neurol Neurosurg Psychiatry 75:1036-8. 2004
  7. ncbi Polymorphisms in the transcobalamin gene: association with plasma homocysteine in healthy individuals and vascular disease patients
    Karin J A Lievers
    Departments of Pediatrics, Division of Endocrinology, University Medical Center Nijmegen, 6500 HB Nijmegen, The Netherlands
    Clin Chem 48:1383-9. 2002
  8. ncbi No association between the MTHFR A1298C and transcobalamin C776G genetic polymorphisms and hyperhomocysteinemia in thrombotic disease
    Henrik Zetterberg
    Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg University, Sweden
    Thromb Res 108:127-31. 2002
  9. ncbi Transcobalamin polymorphism and serum holo-transcobalamin in relation to Alzheimer's disease
    Andrew McCaddon
    University of Wales College of Medicine, Division of General Practice, Wrexham, UK
    Dement Geriatr Cogn Disord 17:215-21. 2004
  10. pmc Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway
    Aditi Hazra
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Hum Mol Genet 18:4677-87. 2009

Research Grants

  1. Modeling TH17 Cells in Acute GVHD
    JONATHAN STUART SERODY; Fiscal Year: 2010
  2. JONATHAN STUART SERODY; Fiscal Year: 2016
  3. Role of C/EBPepsilon in myeloid differentiation
    Stephanie Halene; Fiscal Year: 2010
  4. Mary L Disis; Fiscal Year: 2014
  5. CXCL16 as a therapeutic target for atherosclerosis
    Shuhua Han; Fiscal Year: 2010
  6. STRUCTURAL BASIS OF VITAMIN B12 (COBALAMIN) DEFICIENCY
    Heidi Schubert; Fiscal Year: 2002
  7. PAUL CAMILLE TUMEH; Fiscal Year: 2015
  8. Quiescent Tc17 programmed CD8 T cells and their role in graft versus host disease
    CAMERON JOHN TURTLE; Fiscal Year: 2012
  9. CAMERON JOHN TURTLE; Fiscal Year: 2015
  10. Christopher M Walker; Fiscal Year: 2016

Detail Information

Publications208 found, 100 shown here

  1. ncbi Heteronuclear NMR studies of cobalt corrinoids. 20. 31P chemical shift anisotropy of aquacobalamin and its complex with a haptocorrin from chicken serum
    K L Brown
    Department of Chemistry, Clippinger Laboratory, Ohio University, Athens 45701, USA
    J Inorg Biochem 71:199-204. 1998
    ..3 kDa) and second virial coefficient (3.66 x 10(-4) mol mL g-2) for the complex between chicken serum haptocorrin (HC) and aquacobalamin (H2OCbl)...
  2. ncbi Haptocorrin in humans
    Anne L Morkbak
    Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
    Clin Chem Lab Med 45:1751-9. 2007
    Evolutionary haptocorrin is the youngest of the cobalamin-binding proteins. It evolved by duplication of the intrinsic factor gene and has been identified in most mammals examined...
  3. doi Low fresh gas flow balanced anesthesia versus target controlled intravenous infusion anesthesia in laparoscopic cholecystectomy: a cost-minimization analysis
    Predrag D Stevanovic
    Clinic of Anaesthesiology and Reanimatology, Clinical Center Dr D Misovic DEDINJE, University of Belgrade, Belgrade, Republic of Serbia
    Clin Ther 30:1714-25. 2008
    ..It is also considered cost saving because it has been associated with a decreased hospital length of stay. Variables that might lead to increased costs in laparoscopic surgery are the technique and drugs used in anesthesia...
  4. doi Effect of temperature on thermal acclimation in growing pigs estimated using a nonlinear function
    D Renaudeau
    INRA UR143 Unité de Recherches Zootechniques, Petit Bourg, Guadeloupe, France
    J Anim Sci 88:3715-24. 2010
    ..The thermal circulation index (TCI) was determined from rectal, cutaneous, and ambient temperature measurements...
  5. pmc Chagas cardiomyopathy manifestations and Trypanosoma cruzi genotypes circulating in chronic Chagasic patients
    Juan David Ramírez
    Centro de investigaciones en Microbiología y Parasitología Tropical CIMPAT, Facultad de Ciencias, Departamento de Ciencias Biologicas, Universidad de Los Andes, Bogota, Colombia
    PLoS Negl Trop Dis 4:e899. 2010
    ..cruzi parasite is classified into six discrete taxonomic units (DTUs) based on the recently proposed nomenclature (TcI, TcII, TcIII, TcIV, TcV and TcVI)...
  6. pmc Association of IL-1 RN*2 allele and methionine synthase 2756 AA genotype with dementia severity of sporadic Alzheimer's disease
    P Bosco
    IRCCS Associazione Oasi Maria SS, Institute for Research on Mental Retardation and Brain Aging, Troina, Italy
    J Neurol Neurosurg Psychiatry 75:1036-8. 2004
    ..Genetic polymorphisms of APO-E, homocysteine, and the IL-1 gene cluster (IL-1A, IL-1B, receptor antagonist IL-1RN) are associated with sporadic Alzheimer's disease and may involve interdependent pathways of neuronal toxicity...
  7. ncbi Polymorphisms in the transcobalamin gene: association with plasma homocysteine in healthy individuals and vascular disease patients
    Karin J A Lievers
    Departments of Pediatrics, Division of Endocrinology, University Medical Center Nijmegen, 6500 HB Nijmegen, The Netherlands
    Clin Chem 48:1383-9. 2002
    ....
  8. ncbi No association between the MTHFR A1298C and transcobalamin C776G genetic polymorphisms and hyperhomocysteinemia in thrombotic disease
    Henrik Zetterberg
    Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg University, Sweden
    Thromb Res 108:127-31. 2002
  9. ncbi Transcobalamin polymorphism and serum holo-transcobalamin in relation to Alzheimer's disease
    Andrew McCaddon
    University of Wales College of Medicine, Division of General Practice, Wrexham, UK
    Dement Geriatr Cogn Disord 17:215-21. 2004
    ..008) and between 776C homozygotes and heterozygotes (Cox's F test F(46, 108) = 1.7; p = 0.02). Proportionately fewer TC 776C homozygotes appear to develop AD at any given age, but this will require confirmation in a longitudinal study...
  10. pmc Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway
    Aditi Hazra
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Hum Mol Genet 18:4677-87. 2009
    ..40 x 10(-15)). Genome-wide significant loci were not identified for plasma folate. These data reveal new biological candidates and confirm prior candidate genes for plasma homocysteine, plasma vitamin B12 and plasma PLP...
  11. ncbi Transcobalamin 776C->G polymorphism negatively affects vitamin B-12 metabolism
    Kristina M von Castel-Dunwoody
    Food Science and Human Nutrition Department and the General Clinical Research Center, University of Florida, Gainesville, FL 32611, USA
    Am J Clin Nutr 81:1436-41. 2005
    ..Remethylation of homocysteine is dependent on the production of 5-methyltetrahydrofolate and adequate vitamin B-12 for the methionine synthase reaction...
  12. ncbi Study of four genes belonging to the folate pathway: transcobalamin 2 is involved in the onset of non-syndromic cleft lip with or without cleft palate
    Marcella Martinelli
    Department of Morphology and Embryology, University of Ferrara, Ferrara, Italy
    Hum Mutat 27:294. 2006
    ..triad design to test for linkage disequilibrium in the case of seven SNPs mapping on four different genes: transcobalamin 1 and 2 (TCN1 and TCN2), methionine synthase (MTR), and MTR reductase (MTRR)...
  13. pmc Investigation of CBS, MTR, RFC-1 and TC polymorphisms as maternal risk factors for Down syndrome
    N Fintelman-Rodrigues
    Departamento de Genetica, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil
    Dis Markers 26:155-61. 2009
    ..Our results suggest that maternal folate-related polymorphisms studied here have no influence on trisomy 21 susceptibility in subjects of Brazilian population...
  14. ncbi Effect of vitamin B12 treatment on haptocorrin
    Anne L Mørkbak
    Department of Clinical Biochemistry, Aarhus Sygehus, Denmark
    Clin Chem 52:1104-11. 2006
    b>Haptocorrin (HC) carries the major part of circulating cobalamin, but whether HC is altered on treatment with vitamin B12 remains unknown.
  15. doi Vitamin B12 absorption and metabolism in milk-fed lambs
    T M Gruner
    Animal and Food Sciences Division, Lincoln University, Canterbury 8152, New Zealand
    N Z Vet J 57:22-7. 2009
    ..To quantify aspects of absorption and retention of vitamin B12 from milk in pre-ruminant lambs, and the possible effect of activation of dependent metabolic pathways (propionate-succinate) on vitamin B12 concentrations in tissues...
  16. ncbi Human milk proteins: key components for the biological activity of human milk
    Bo Lonnerdal
    Department of Nutrition and Program of International Nutrition, University of California, Davis, CA 95616, USA
    Adv Exp Med Biol 554:11-25. 2004
    ..Proteins like lactoferrin, secretory IgA, kappa-casein, lactoperoxidase, haptocorrin, lactadherin and peptides formed from human milk proteins during digestion can inhibit the growth of pathogenic ..
  17. doi A new principle for measurement of cobalamin and corrinoids, used for studies of cobalamin analogs on serum haptocorrin
    Tore Forsingdal Hardlei
    Department of Clinical Biochemistry, As, Aarhus University Hospital, Aarhus, Denmark
    Clin Chem 55:1002-10. 2009
    Transcobalamin (TC) and haptocorrin (HC) are serum corrinoid-binding proteins. We developed new methods for measurement of the corrinoids bound to HC and TC.
  18. ncbi The cDNA sequence and the deduced amino acid sequence of human transcobalamin II show homology with rat intrinsic factor and human transcobalamin I
    O Platica
    Department of Medicine, State University of New York Health Science Center, Brooklyn
    J Biol Chem 266:7860-3. 1991
    ..TCII has 20% amino acid homology and greater than 50% nucleotide homology with human transcobalamin I (TCI) and with rat intrinsic factor (R-IF)...
  19. ncbi Isolation and characterization of a cDNA encoding porcine gastric haptocorrin
    J E Hewitt
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110
    Eur J Biochem 189:125-30. 1990
    A cDNA encoding the gastric haptocorrin was isolated from a porcine gastric mucosal lambda gt11 cDNA library using oligonucleotide probes. The 1.4-kb cDNA contains a 1.25-kb open reading frame and 178 nucleotides of 3' noncoding region...
  20. ncbi The minor components of the rat asialoglycoprotein receptor are apically located in neonatal enterocytes
    C B Hu
    Department of Medicine, Washington University Medical School, St Louis, Missouri
    Gastroenterology 101:1477-87. 1991
    Because specific uptake of the asialoglycoprotein haptocorrin has been reported in suckling distal intestine, evidence of the asialoglycoprotein receptor in rat ileum was sought...
  21. ncbi Conformational changes of transcobalamin induced by aquocobalamin binding. Mechanism of substitution of the cobalt-coordinated group in the bound ligand
    S N Fedosov
    Protein Chemistry Laboratory, Department of Molecular and Structural Biology, University of Aarhus, Science Park, Gustav Wieds Vej 10, Denmark
    J Biol Chem 275:11791-8. 2000
    ..OH(2), Cbl.CN, and Cbl.N(3), respectively) to the recombinant human transcobalamin (TC) and haptocorrin from human plasma was investigated via stopped-flow spectroscopy...
  22. doi High concentrations of haptocorrin interfere with routine measurement of cobalamins in human serum and milk. A problem and its solution
    Dorte L Lildballe
    Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
    Clin Chem Lab Med 47:182-7. 2009
    Human milk and occasional serum samples contain high concentrations of unsaturated haptocorrin, which influence accurate measurement of cobalamins.
  23. pmc Identification and characterization of Tc1/mariner-like DNA transposons in genomes of the pathogenic fungi of the Paracoccidioides species complex
    Marjorie M Marini
    Departamento de Microbiologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, 31270 901 Belo Horizonte, MG, Brazil
    BMC Genomics 11:130. 2010
    ..In this study the identification and characterization of class II transposable elements in the genomes of these fungi was carried out...
  24. ncbi Analysis of Th1 and Th2 cytokines expressing CD4+ and CD8+ T cells in rheumatoid arthritis by flow cytometry
    B Berner
    Department of Nephrology and Rheumatology, Georg August University of Goettingen, Germany
    J Rheumatol 27:1128-35. 2000
    ..Results were compared with 10 PB samples from healthy controls (HC) and 5 SF samples from patients with non-RA synovitis...
  25. ncbi A convergent validity study of Cloninger's Temperament and Character Inventory with the Coolidge Axis II Inventory
    J Griego
    University of New Mexico, USA
    J Pers Disord 13:257-67. 1999
    This study examined the convergent validity of the Temperament and Character Inventory (TCI), a measure of four biosocial temperaments and three character dimensions with the Coolidge Axis II Inventory (CATI), a measure of 14 personality ..
  26. doi Association between tinnitus retraining therapy and a tinnitus control instrument
    Mari Ito
    Department of Otolaryngology, Nippon Kokan Hospital and Kokan Clinic, Kokan tori, Kawasaki ku, Kawasaki, Japan
    Auris Nasus Larynx 36:536-40. 2009
    ..proposed by Jastreboff in 1990,consists of directive counseling and acoustic therapy with a tinnitus control instrument (TCI) or other devices. For the past 5 years, our hospital has administered TRT characterized by the use of a TCI.
  27. doi Cloud condensation nuclei and ice nucleation activity of hydrophobic and hydrophilic soot particles
    Kirsten A Koehler
    Department of Atmospheric Science, Colorado State University, Fort Collins, CO 80523, USA
    Phys Chem Chem Phys 11:7906-20. 2009
    ..TS; graphitized: GTS; and oxidized: TOS), soot from a diffusion flame in an oil lamp burning aviation kerosene (TC1), and soot from a turbulent diffusion flame in an aircraft engine combustor (AEC)...
  28. pmc Transcutaneous immunization with cross-reacting material CRM(197) of diphtheria toxin boosts functional antibody levels in mice primed parenterally with adsorbed diphtheria toxoid vaccine
    Paul Stickings
    Division of Bacteriology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, United Kingdom
    Infect Immun 76:1766-73. 2008
    Transcutaneous immunization (TCI) capitalizes on the accessibility and immunocompetence of the skin, elicits protective immunity, simplifies vaccine delivery, and may be particularly advantageous when frequent boosting is required...
  29. ncbi Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl-CoA carboxylase
    M R Munday
    MRC Protein Phosphorylation Group, Biochemistry Department, University of Dundee, Tayside, Scotland
    Eur J Biochem 175:331-8. 1988
    ..The two sites phosphorylated by each kinase can be recovered on separate peptides, TC1 and TC2, derived by combined digestion of the native enzyme by trypsin and chymotrypsin: TC1 = Ser-2Ser(P)-Met-3Ser(..
  30. pmc Temperament and character as schizophrenia-related endophenotypes in non-psychotic siblings
    Matthew J Smith
    Northwestern University, Feinberg School of Medicine, Department of Psychiatry and Behavioral Sciences, Chicago, IL 60611, United States
    Schizophr Res 104:198-205. 2008
    ..Thus, measures of temperament and character may serve as schizophrenia-related endophenotypes in individuals with schizophrenia and their non-psychotic siblings...
  31. doi Personality dimensions measured using the Temperament and Character Inventory (TCI) and NEO-FFI on a Polish sample
    Elzbieta Mikołajczyk
    Department of Psychiatry, Pomeranian Medical University, Szczecin, Poland
    Int J Methods Psychiatr Res 17:210-9. 2008
    ..on biosocial theory of personality have been compared simultaneously: the Temperament and Character Inventory (TCI) and NEO Five Factor Inventory (NEO-FFI)...
  32. doi The Narcotrend index indicates age-related changes during propofol induction in children
    Sinikka Münte
    Department of Anesthesiology and Intensive Care Medicine, Children s Hospital, Helsinki University Clinics, PL 281, 00029 HUS, Finland
    Anesth Analg 109:53-9. 2009
    ..We performed this study to evaluate the effectiveness and reliability of the Narcotrend monitor in assessing hypnotic state and loss of consciousness (LOC) during propofol anesthesia induction in children...
  33. pmc Genetically different isolates of Trypanosoma cruzi elicit different infection dynamics in raccoons (Procyon lotor) and Virginia opossums (Didelphis virginiana)
    Dawn M Roellig
    Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30606, USA
    Int J Parasitol 39:1603-10. 2009
    ..cruzi I (TcI) and TcIIa, while opossums would only serve as hosts for TcI...
  34. ncbi Temperament, character, and personality disorders
    S M de la Rie
    Department of Clinical and Health Psychology, Leiden University, The Netherlands
    J Pers Disord 12:362-72. 1998
    ..study compares two self-report instruments--the Dutch version of Cloninger's Temperament and Character Inventory (TCI) and the Questionnaire on Personality Traits (VKP)--in a Dutch sample of 148 people in a healthy population...
  35. ncbi Genomic and evolutionary analyses of Tango transposons in Aedes aegypti, Anopheles gambiae and other mosquito species
    M R Coy
    Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Insect Mol Biol 16:411-21. 2007
    Tango is a transposon of the Tc1 family and was originally discovered in the African malaria mosquito, Anopheles gambiae...
  36. ncbi A study of affective temperaments in Hungary: internal consistency and concurrent validity of the TEMPS-A against the TCI and NEO-PI-R
    Sandor Rozsa
    Department of Personality and Health Psychology, Lorand Eotvos University, Budapest, Hungary
    J Affect Disord 106:45-53. 2008
    ..of Mood States (POMS), the BarOn Emotional Quotient Inventory (BarOn EQ-i), Temperament and Character Inventory (TCI), and the NEO Personality Inventory - Revised (NEO-PI-R)...
  37. pmc Experimental infection of two South American reservoirs with four distinct strains of Trypanosoma cruzi
    Dawn M Roellig
    Southeastern Cooperative Wildlife Disease Study, Department of Population Health, The University of Georgia, Athens, GA 30602, USA
    Parasitology 137:959-66. 2010
    Trypanosoma cruzi (Tc), the causative agent of Chagas disease, is a diverse species with 2 primary genotypes, TcI and TcII, with TcII further subdivided into 5 subtypes (IIa-e)...
  38. ncbi Effects of low doses of hydrochloride tetracycline on bone metabolism and uterus in ovariectomized rats
    Qing nan Li
    Bone Biology Laboratory, Guangdong Medical College, Zhanjiang 524023, China
    Acta Pharmacol Sin 24:599-604. 2003
    ..To study the effects of low doses of hydrochloride tetracycline (Tc) on bone metabolism and uterus in the ovariectomized (Ova) rats...
  39. ncbi [Terminal cardiac failure. Circulatory assist devices]
    D Duveau
    Clinique chirurgicale thoracique et cardiovasculaire, , Nantes
    Arch Mal Coeur Vaiss 89:51-4. 1996
    ..external heterotopic uni/biventricular assist devices (Thoractec, Medos) or implantable heterotopic left ventricle (TCI), or orthotopic and implantable total artificial heart (Jarvik-CardioWest)...
  40. ncbi Promoter sequences regulated by the calcineurin-activated transcription factor Crz1 in the yeast ENA1 gene
    I Mendizabal
    Universidad del Pais Vasco, Facultad de Ciencias Quimicas, Departamento de Quimica Aplicada, San Sebastian, Spain
    Mol Genet Genomics 265:801-11. 2001
    ..the molecular mechanisms involved in ENA1 induction by the calcium-calcineurin-activated transcription factor Crzl/Tcn1. We found in the ENA1 promoter a calcium-responsive, Crzl-dependent upstream activating region (UASENA1) located ..
  41. ncbi [Comparison between TCI-TIVA, manual TIVA and balanced anaesthesia for stereotactic biopsy of the brain]
    B Weninger
    Klinik für Anästhesiologie und Intensivmedizin der Ludwig Maximilians Universität München, Munich
    Anasthesiol Intensivmed Notfallmed Schmerzther 39:212-9. 2004
    ....
  42. ncbi Temperament and character profiles of patients with tension-type headache and migraine
    Cavit Boz
    Department of Neurology, Medical Faculty of Karadeniz Technical University, Trabzon, Turkey
    Psychiatry Clin Neurosci 58:536-43. 2004
    ..All participants were instructed to complete a self-administered 240-item temperament and character inventory (TCI) questionnaire and Beck Depression Inventory (BDI)...
  43. ncbi Repeat structure of the catfish genome: a genomic and transcriptomic assessment of Tc1-like transposon elements in channel catfish (Ictalurus punctatus)
    Samiran Nandi
    Department of Fisheries and Allied Aquacultures, The Fish Molecular Genetics and Biotechnology Laboratory, Program of Cell and Molecular Biosciences, Auburn University, Auburn, AL 36849, USA
    Genetica 131:81-90. 2007
    We have assessed the distribution and diversity of members of the Tc1/mariner superfamily of transposable elements in the channel catfish (Ictalurus punctatus) genome as well as evaluating the extent of transcription of Tc1 transposases ..
  44. doi Intradermal injections of polyarginine-containing immunogenic antigens preferentially elicit Tc1 and Th1 activation and antitumour immunity
    H Mitsui
    Department of Dermatology, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo shi, Yamanashi 409 3898, Japan
    Br J Dermatol 162:29-41. 2010
    ..rR9-containing immunogenic Ag without adjuvants simultaneously induce dual immunological effects: the induction of Tc1- and Th1-dominant immune responses, and the induction of inflammatory and CTL-mediated immune responses at the ..
  45. ncbi Combining the Rorschach test and the Temperament Character Inventory: a new perspective on personality assessment
    S Fassino
    Department of Neurosciences, Psychiatry Section, Torino University School of Medicine, Via Cherasco 11, I 10126 Turin, Italy
    Psychopathology 36:84-91. 2003
    ..e. the Rorschach test) often lack objectivity. This study compared the results of personality assessment with the Temperament and Character Inventory (TCI) and the Rorschach test to verify their validity.
  46. ncbi Polymorphisms in the serotonin transporter and monoamine oxidase A genes and their relationship to personality traits measured by the Temperament and Character Inventory and NEO Five-Factor Inventory in healthy volunteers
    Jerzy Samochowiec
    Department of Psychiatry, Pomeranian Medical University, Szczecin, Poland
    Neuropsychobiology 50:174-81. 2004
    ..oxidase A (MAOA)-LPR and the dimensions of temperament evaluated using the Temperament and Character Inventory (TCI) and NEO Five-Factor Inventory (NEO-FFI) were studied...
  47. ncbi Preferential expression of very late antigen-4 on type 1 CTL cells plays a critical role in trafficking into central nervous system tumors
    Kotaro Sasaki
    Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Cancer Res 67:6451-8. 2007
    We have previously shown preferential tumor-homing and therapeutic efficacy of adoptively transferred type 1 CTL (Tc1) when compared with type 2 CTL (Tc2) in mice bearing intracranial ovalbumin-transfected melanoma (M05)...
  48. pmc Target concentration intervention is needed for tobramycin dosing in paediatric patients with cystic fibrosis--a population pharmacokinetic study
    Stefanie Hennig
    School of Pharmacy, The University of Queensland, Brisbane, Australia
    Br J Clin Pharmacol 65:502-10. 2008
    ..variability (BOV), which is necessary to justify and draw conclusions about the use of target concentration intervention (TCI). * In the publications no simulations were provided to show any new directions or evaluate current therapy.
  49. doi A comparison of induction of anaesthesia using a target-controlled infusion device in dogs with propofol or a propofol and alfentanil admixture
    Adam Auckburally
    Division of Small Animal Clinical Studies, Institute of Comparative Medicine, University of Glasgow Veterinary School, Bearsden Road, Bearsden, Glasgow, UK
    Vet Anaesth Analg 35:319-25. 2008
    To compare induction targets, and the haemodynamic and respiratory effects, of propofol, or as an admixture with two different concentrations of alfentanil, delivered via a propofol target-controlled infusion (TCI) system.
  50. pmc In vitro effector activity of Pneumocystis murina-specific T-cytotoxic-1 CD8+ T cells: role of granulocyte-macrophage colony-stimulating factor
    Florencia McAllister
    Children s Hospital of Pittsburgh, Department of Pediatrics, Suite 3765, 3705 Fifth Ave, Pittsburgh, PA 15213, USA
    Infect Immun 73:7450-7. 2005
    ..We have previously shown using adoptive transfer studies that in vivo-generated T-cytotoxic-1 (Tc1) CD8+ T cells, defined by the secretion of gamma interferon (IFN-gamma), have effector activity against ..
  51. ncbi Growth behaviour of two Trypanosoma cruzi strains in single and mixed infections: In vitro and in the intestinal tract of the blood-sucking bug, Triatoma brasiliensis
    Catarina A C Araújo
    Departamento de Protozoologia, Instituto Oswaldo Cruz, FIOCRUZ, Avenida Brasil, 4365 Manguinhos, RJ, Brazil
    Acta Trop 101:225-31. 2007
    ..mixed infection was evaluated using two isolates of Trypanosoma cruzi, previously typed as belonging to genotypes TcI and TcII. The growth in vitro and in the different compartments of the gut of Triatoma brasiliensis was studied...
  52. doi The psychobiological theory of temperament and character: comment on Farmer and Goldberg (2008)
    C Robert Cloninger
    Washington University, Department of Psychiatry, School of Medicine, St Louis, MO 63110, USA
    Psychol Assess 20:292-9; discussion 300-4. 2008
    The revised Temperament and Character Inventory (TCI-R) is the third stage of development of a widely used multiscale personality inventory that began with the Tridimensional Personality Questionnaire (TPQ) and then the Temperament and ..
  53. ncbi Clinical evaluation of target controlled infusion system for sufentanil administration
    Yan Zhao
    Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China
    Chin Med J (Engl) 122:2503-8. 2009
    Sufentanil target controlled infusion (TCI) provides stable analgesia, better hemodynamic control than a bolus injection of intravenous anesthetics, anticipated recovery and improved quality of anesthesia during perioperative period...
  54. pmc Molecular and genetic analysis of unc-7, a Caenorhabditis elegans gene required for coordinated locomotion
    T A Starich
    Department of Genetics and Cell Biology, University of Minnesota, St Paul 55108
    Genetics 133:527-41. 1993
    ..We have cloned unc-7 by transposon tagging: an unc-7 mutation was correlated with the insertion of the transposon Tc1, and reversion of the mutant phenotype was correlated with loss of the Tc1 element...
  55. ncbi Th2 and Tc2 cells in the regulation of GVHD, GVL, and graft rejection: considerations for the allogeneic transplantation therapy of leukemia and lymphoma
    D H Fowler
    National Cancer Institute, Department of Experimental Transplantation and Immunology, Bethesda, MD, USA
    Leuk Lymphoma 38:221-34. 2000
    ..T cells exist in four functionally-defined populations, the CD4+, Th1/Th2 and CD8+, Tc1/Tc2 subsets...
  56. ncbi Pharmacokinetics of sufentanil administered by target-controlled infusion in Chinese surgical patients
    Yan Zhao
    Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China
    Chin Med J (Engl) 122:291-5. 2009
    Target-controlled infusion (TCI) has been recently developed and successfully implemented in clinical practice. This study was conducted to determine the pharmacokinetics of TCI administered sufentanil in Chinese surgical patients.
  57. ncbi [Regulation of immunological balance between TH1/TH2 and Tc1/Tc2 lymphocytes by prostaglandin E2]
    Yu Shi Bao
    Department of Renal Diseases, The First Affliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang Province, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 18:431-5. 2010
    ..blood T lymphocytes, and to evaluate the regulatory role of PGE2 on immunological balance between Th1/Th2 and Tc1/Tc2 lymphocytes...
  58. ncbi Bridging-to-recovery
    R Hetzer
    Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum, Berlin, Germany
    Ann Thorac Surg 71:S109-13; discussion S114-5. 2001
    ..In a subgroup of selected patients, some hearts recovered considerable function. In these patients the device was removed and cardiac transplantation was no longer necessary. We report our long-term experience with these weaned patients...
  59. doi The relationship between bispectral index and propofol during target-controlled infusion anesthesia: a comparative study between children and young adults
    Agnes Rigouzzo
    Service d anesthésie pédiatrique, Hopital Armand Trousseau, Paris, France
    Anesth Analg 106:1109-16, table of contents. 2008
    In this prospective study, we compared the relationship between propofol concentrations and bispectral index (BIS) in children versus young adults anesthetized with target-controlled infusion (TCI) of propofol.
  60. ncbi [Effect of high mobility group box 1 protein on proliferation and apoptosis and balance between Th1/Th2 and Tc1/Tc2 of lymphocytes in vitro]
    Zhong Tang Wang
    Department of Plastic Surgery, Zhongshan Hospital, Xiamen University, Xiamen 361004, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 24:324-7. 2008
    ..To explore whether extracellular high mobility group B1 protein (HMGB1) plays a role in regulation of lymphocyte-mediated immune...
  61. ncbi Oral clonidine premedication reduces the EC50 of propofol concentration for laryngeal mask airway insertion in male patients
    H Higuchi
    Department of Anesthesia, Self Defense Force Central Hospital, Tokyo, Japan
    Acta Anaesthesiol Scand 46:372-7. 2002
    ..Target-controlled infusion (TCI) is becoming increasingly popular for propofol infusion...
  62. ncbi Identification and intracellular localization of the unc-22 gene product of Caenorhabditis elegans
    D G Moerman
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110
    Genes Dev 2:93-105. 1988
    ..Since cloning the unc-22 gene by transposon tagging, we have used conventional techniques combined with a set of Tc1 transposon insertion alleles to characterize the gene and its products...
  63. ncbi Endogenous tumor necrosis factor-alpha production by a pancreatic beta-cell line: inhibitory effects of hydrocortisone and nicotinamide
    K Yamada
    Department of Medicine, Kurume University School of Medicine, Japan
    Life Sci 59:1423-9. 1996
    ..of interleukin-1(IL-1)-induced tumor necrosis factor-alpha (TNF-alpha) production by a mouse beta-cell line (beta TC1)...
  64. doi Differentially expressed genes in human peripheral blood as potential markers for statin response
    Hong Hee Won
    Samsung Biomedical Research Institute, Samsung Medical Center, Seoul 135 710, South Korea
    J Mol Med (Berl) 90:201-11. 2012
    ..The Charcol-Leyden crystal (CLC), CCR2, CX3CR1, LRRN3, FOS, LDLR, HLA-DRB1, ERMN, and TCN1 genes were significantly associated with cholesterol levels or statin response...
  65. doi Multiple effects of pepstatin A on Trypanosoma cruzi epimastigote forms
    Leandro S Sangenito
    Laboratório de Bioquímica de Proteases, Departamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes IMPG, Universidade Federal do Rio de Janeiro UFRJ, Rio de Janeiro, Brazil
    Parasitol Res 110:2533-40. 2012
    ..Pepstatin A arrested the proliferation of epimastigotes of T. cruzi (clone Dm28c, TcI lineage), in both dose- and time-dependent manner. The IC(50) value was calculated to be 36...
  66. doi Engineering the Caenorhabditis elegans genome by Mos1-induced transgene-instructed gene conversion
    Valérie J P Robert
    Laboratory of Molecular and Cellular Biology, Ecole Normale Superieure de Lyon, Lyon, France
    Methods Mol Biol 859:189-201. 2012
    ..MosTIC is initiated by the excision of Mos1, a DNA transposon of the Tc1/Mariner super family that can be mobilized in the germ line of C. elegans...
  67. doi Changes in total and unbound concentrations of sufentanil during target controlled infusion for cardiac surgery with cardiopulmonary bypass
    C Jeleazcov
    Department of Anaesthesiology, Friedrich Alexander University Erlangen Nuremberg, Krankenhausstrasse 12, Erlangen, Germany
    Br J Anaesth 109:698-706. 2012
    Target controlled infusion (TCI) with sufentanil is usually performed using the Gepts model, which was derived from patients undergoing general surgery...
  68. doi Cross-cultural validation of the revised temperament and character inventory in the Bulgarian language
    Boris Tilov
    Department of Healthcare Management, Faculty of Public Health, Medical University, Plovidv, Bulgaria
    J Eval Clin Pract 18:1180-5. 2012
    ..The primary goal of this study was to test the conceptual validity and cross-cultural applicability of the revised TCI (TCI-R), developed in the United States, in a culturally, socially and economically diverse setting.
  69. ncbi [The association between beta-adrenergic receptor gene polymorphisms and personality traits]
    Maki Numajiri
    Laboratory of Neurophysiology the Graduate School of Environmental Health Sciences Azabu University, 1 17 71 Fuchinobe, Chuo Ku, Sagamihara, 252 5201 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 32:227-31. 2012
    ..between the polymorphisms (SNPs) of the beta-adrenergic receptor (beta-AR) gene and personality assessed by TCI (Temperament and Character Inventory), was studied among 192 healthy Japanese subjects (121 male subjects and 71 ..
  70. ncbi [Evaluation of propofol target controlled infusion with fentanyl intravenous sedation on the removal of impacted wisdom tooth]
    Ming Guan
    Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, China
    Beijing Da Xue Xue Bao 46:107-10. 2014
    To evaluate the effect and safety of propofol target controlled infusion (TCI) with a small dosage of fentanyl intravenous sedation on the removal of the third impacted molar tooth.
  71. doi Personality traits associated with suicidal behaviors in patients with depression: the CRESCEND study
    Ho Jun Seo
    Department of Psychiatry, St Vincent Hospital, College of Medicine, The Catholic University of Korea, Suwon, Republic of Korea Clinical Research Center for Depression, Seoul, Republic of Korea
    Compr Psychiatry 55:1085-92. 2014
    ..2%) who completed the Temperament and Character Inventory (TCI) were included in these analyses...
  72. doi Heterogeneity in the differentiation and function of CD8⁺ T cells
    Hans Willi Mittrücker
    Institute for Immunology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Arch Immunol Ther Exp (Warsz) 62:449-58. 2014
    ..fulfilled by the best characterized subpopulation of CD8(+) T cells, the cytotoxic T lymphocytes (also called Tc1 cells), owing to their ability to kill infected cells and to secrete cytokines such as interferon-γ and tumor ..
  73. doi Remifentanil target-controlled infusion: a safe rescue protocol for unexpected severe postoperative pain
    Cyrus Motamed
    Anesthesia Department, Institut Gustave Roussy, Villejuif, France
    J Opioid Manag 10:284-8. 2014
    Three cases are reported here in which remifentanil administered as a target-controlled infusion (TCI) was used in Post Anesthesia Care Unit as a fast rescue treatment for acute and unexpected severe postoperative pain, allowing ..
  74. doi Obsessive-compulsive disorders and anxiety disorders: A comparison of personality and emotionality patterns
    Antoine Pelissolo
    AP HP, Service de Psychiatrie, Hopital Henri Mondor, Université Paris Est Créteil, INSERM U955, Fondation FondaMental, Creteil, France Electronic address
    Psychiatry Res 229:695-701. 2015
    ..We used the Temperament and Character Inventory (TCI-R) and the Positive and Negative Emotionality (PNE) scale to compare two groups of patients with OCD (n=227) or AD (..
  75. pmc A preliminary proteomic characterisation of extracellular vesicles released by the ovine parasitic nematode, Teladorsagia circumcincta
    Thomas Tzelos
    Moredun Research Institute, Pentlands Science Park, Bush Loan, EH26 0PZ, Edinburgh, UK Electronic address
    Vet Parasitol 221:84-92. 2016
    ..circumcincta fourth stage larvae (Tci-L4ES). Furthermore, we perform a comparative proteomic analysis of vesicle-enriched and vesicle-free Tci-L4ES...
  76. pmc Genetic analysis of a major segment [LGV(left)] of the genome of Caenorhabditis elegans
    R C Johnsen
    Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia, Canada
    Genetics 129:735-52. 1991
    ..Another gene in the sparse region, lin-40, and the region near lin-40 are major targets for Tc1 mobilization-induced mutagenesis. The analysis of essential genes in large regions should help to define C...
  77. ncbi The insertion sequence element ISRm2011-2 belongs to the IS630-Tc1 family of transposable elements and is abundant in Rhizobium meliloti
    W Selbitschka
    Lehrstuhl fur Genetik, Universitat Bielefeld, Germany
    Gene 163:59-64. 1995
    ..The protein encoded by ORFB shows homology to transposases (Tps) of the recently proposed IS630-Tc1 family which includes Tps of both prokaryotic and eukaryotic transposable elements...
  78. ncbi Diminished contact hypersensitivity response in IL-4 deficient mice at a late phase of the elicitation reaction
    B Weigmann
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    Scand J Immunol 45:308-14. 1997
    Contact hypersensitivity (CHS) is thought to depend on the activation of T cells of Th1 and/or Tc1 type. The role of Th2/Tc2 cells in the contact allergic reaction is not clear...
  79. ncbi HeartSaver VAD: a totally implantable ventricular assist device. Results of in vivo studies
    T Mussivand
    Cardiovascular Devices Division, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Extra Corpor Technol 32:184-9. 2000
    ..g., Thoratec, Abiomed) or intra-abdominally (e.g., Novacor, TCI)...
  80. ncbi Tobacco and Arabidiopsis SLT1 mediate salt tolerance of yeast
    T K Matsumoto
    Center for Plant Environmental Stress Physiology, Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN 47907 1165, USA
    Plant Mol Biol 45:489-500. 2001
    ..transcription of the CaN-dependent ENA1 gene promoter and compensated the salt sensitivity of a mutant deficient in TCN1--a transcription factor that is activated by CaN and then induces ENA1 expression...
  81. ncbi CD8 T cells inhibit IgE via dendritic cell IL-12 induction that promotes Th1 T cell counter-regulation
    Matthew J Thomas
    Department of Immunology, Guy s, King s, and St Thomas s School of Medicine, Kings College, Rayne Institute, 123 Coldharbour Lane, London, SE5 9NU, United Kingdom
    J Immunol 168:216-23. 2002
    ..Transfer of either Tc1 or Tc2 Valpha2Vbeta5 TCR-transgenic CD8 T cells inhibited IgE and OVA-specific Th2 cells while promoting OVA-..
  82. ncbi Personality dimensions in social phobics with or without depression
    A Pelissolo
    Service de Psychiatrie, Hopital Fernand Widal, Assistance Publique Hopitaux de Paris, France
    Acta Psychiatr Scand 105:94-103. 2002
    This study investigated the personality traits of social phobics using the Temperament and Character Inventory (TCI).
  83. ncbi Personality dimensions measured by the Temperament and Character Inventory (TCI) in subjects with social phobia
    Ina Marteinsdottir
    Department of Neuroscience, Psychiatry, Uppsala University, Sweden
    Nord J Psychiatry 57:29-35. 2003
    The present study investigated personality dimensions by means of the Temperament and Character Inventory (TCI) in subjects with social phobia with or without a co-existing avoidant personality disorder...
  84. ncbi Glycosylation independent measurement of the cobalamin binding protein haptocorrin
    Anne L Morkbak
    Department of Clinical Biochemistry, NBG, AS Aarhus University Hospital, Nørrebrogade 44, Aarhus DK 8000, Denmark
    Clin Chim Acta 356:184-90. 2005
    b>Haptocorrin carries the major part of the circulating vitamin B12. The protein is heavily glycosylated and this may have implications for its measurement.
  85. ncbi Propofol concentration requirement for laryngeal mask airway insertion was highest with the ProSeal, next highest with the Fastrach, and lowest with the Classic type, with target-controlled infusion
    Fumi Handa-Tsutsui
    Department of Anesthesia, Saitama Medical Center, Saitama Medical School, Saitama 350 8550, Japan
    J Clin Anesth 17:344-7. 2005
    ..50% (Cp50, concentration at which there is a 50% chance that patients show no movement in response) for the Classic-, Fastrach-, and ProSeal-type laryngeal mask airway (LMA) insertion using target-controlled infusion (TCI) technique.
  86. ncbi 'Autistic' traits in non-autistic Japanese populations: relationships with personality traits and cognitive ability
    Yura Kunihira
    Department of Cognitive and Behavioral Sciences, The University of Tokyo, 153 8902, Tokyo, Japan
    J Autism Dev Disord 36:553-66. 2006
    ..Results showed the AQ was associated with tendencies toward an obsessional personality as defined by the TCI (Temperament and Character Inventory), higher depression and anxiety, and higher frequency of experience of being ..
  87. ncbi [Troponin I values during rhabdomyolysis in elderly patients admitted to the emergency department]
    Alain Viallon
    Service d Urgence et de Réanimation, Hopital Bellevue, Saint Etienne
    Presse Med 35:1632-8. 2006
    The objective of this study was to assess the utility of determining serum cardiac troponin I (TcI) levels in the elderly.
  88. ncbi CD8-mediated type 1 antitumor responses selectively modulate endogenous differentiated and nondifferentiated T cell localization, activation, and function in progressive breast cancer
    Mark J Dobrzanski
    Department of Internal Medicine, Texas Tech University School of Medicine, 1400 Wallace Boulevard, Amarillo, TX 79106, USA
    J Immunol 177:8191-201. 2006
    ..Type I CD8 T cells (Tc1) produce IFN-gamma, whereas type 2 cells (Tc2) secrete IL-4, IL-5, IL-10, and GM-CSF...
  89. ncbi Th1 and type 1 cytotoxic T cells dominate responses in T-bet overexpression transgenic mice that develop contact dermatitis
    Kazusa Ishizaki
    Department of Anatomy and Embryology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    J Immunol 178:605-12. 2007
    ..Recently, it has become clear that both CD4(+) Th1 and CD8(+) type 1 cytotoxic T (Tc1) cells can act as effectors in CHS reactions...
  90. ncbi Relationship between personality disorder symptoms and temperament in the young male general population of South Korea
    Jee Hyun Ha
    Department of Psychiatry, School of Medicine, Konkuk University, Seoul, Korea
    Psychiatry Clin Neurosci 61:59-66. 2007
    ..Subjects completed the Personality Disorder Questionnaire-IV+ (PDQ-IV+) and Temperament and Character Inventory (TCI). There were unique correlations between each personality disorder symptom and four temperament profiles...
  91. doi Target-controlled infusion versus manually-controlled infusion of propofol for general anaesthesia or sedation in adults
    Kate Leslie
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Parkville, Vic, Australia, 3050
    Cochrane Database Syst Rev . 2008
    ..be manually controlled (MCI) where the anaesthetist makes each change to the infusion rate or target-controlled (TCI) where the anaesthetist sets a target blood or effect-site concentration and the computerised infusion device makes ..
  92. doi The Team Climate Inventory: application in hospital teams and methodological considerations
    M Ouwens
    Centre for Quality of Care Research, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Qual Saf Health Care 17:275-80. 2008
    ..validity, reliability and discriminating capacity of an instrument to assess team climate, the Team Climate Inventory (TCI), in a sample of Dutch hospital teams. The TCI is based on a four-factor theory of team climate for innovation.
  93. doi High-resolution array comparative genomic hybridization analysis reveals unanticipated complexity of genetic deficiencies on chromosome V in Caenorhabditis elegans
    Martin R Jones
    Department of Medical Genetics, Life Sciences Centre, University of British Columbia, Vancouver BC, Canada
    Mol Genet Genomics 282:37-46. 2009
    ..Additionally, we confirm that transposon-induced deficiencies contain breakpoints that initiate at Tc1 elements...
  94. doi Novelty seeking among adult women is lower for the winter borns compared to the summer borns: replication in a large Finnish birth cohort
    Jayanti Chotai
    Division of Psychiatry, Department of Clinical Sciences, University of Umea, 901 85 Umea, Sweden
    Compr Psychiatry 50:562-6. 2009
    Earlier general population studies have shown that novelty seeking (NS) of the Temperament and Character Inventory (TCI) of personality is lower for persons born in winter compared to those born in summer, particularly for women...
  95. ncbi [Detection of peripheral blood Th1/Th2 and Tc1/Tc2 subsets in patients with condyloma acuminatum and its significance]
    Ning Zhu
    Department of Dermatology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou 310053, China
    Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 23:229-31. 2009
    ..To investigate the role of T-helper (Th) and cytotoxic T (Tc) lymphocyte polarization in the pathogenesis of condyloma acuminatum (CA) and its correlation with recurrence...
  96. doi Combining T-cell vaccination and application of agonistic anti-GITR mAb (DTA-1) induces complete eradication of HPV oncogene expressing tumors in mice
    Corinna Hoffmann
    Department of Obstetrics and Gynecology, Charite Campus Benjamin Franklin, Hindenburgdamm, 12200 Berlin, Germany
    J Immunother 33:136-45. 2010
    ..In a second model (TC1), it induced initial tumor mass reduction, but 90% of the animals showed delayed tumor progression...
  97. pmc Shotgun sequencing analysis of Trypanosoma cruzi I Sylvio X10/1 and comparison with T. cruzi VI CL Brener
    Oscar Franzén
    Science for Life Laboratory, Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
    PLoS Negl Trop Dis 5:e984. 2011
    ..We have generated a draft genome sequence of the TcI strain Sylvio X10/1 and compared it to the TcVI reference strain CL Brener to identify lineage-specific features...
  98. pmc IL-33 synergizes with TCR and IL-12 signaling to promote the effector function of CD8+ T cells
    Qianting Yang
    Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Eur J Immunol 41:3351-60. 2011
    ..Its role in CD8(+) T-cell-mediated immune response is, however, not known. Here we find that type 1 cytotoxic T (Tc1) cells cultured in vitro unexpectedly express high levels of the IL-33 receptor ST2...
  99. doi Phylogenetic evidence based on Trypanosoma cruzi nuclear gene sequences and information entropy suggest that inter-strain intragenic recombination is a basic mechanism underlying the allele diversity of hybrid strains
    Renata C Ferreira
    Departamento de Medicina, Disciplina de Infectologia, Universidade Federal de Sao Paulo, Rua Botucatu 740, CEP 04023 900, Sao Paulo, SP, Brazil
    Infect Genet Evol 12:1064-71. 2012
    ..cruzi III-VI. Data presented and discussed here are consistent with a scenario where TcI and TcII are phylogenetically divergent forming a hybrid zone in between (T. cruzi III-VI)...
  100. ncbi [Factorial dimensions of the Millon's MCMI-II in substance addicts]
    Eduardo J Pedrero Pérez
    Instituto de Adicciones, Madrid Salud, Ayuntamiento de Madrid, 28027 Madrid, Spain
    Psicothema 24:661-7. 2012
    ..All participants completed the MCMI-II and the TCI-R. Multivariate exploratory factor analysis was performed...
  101. ncbi [Utility of target controlled infusion technique for deciding the fentanyl infusion rate for post-cholecystectomy pain management in a patient on anticoagulant therapy]
    Kota Kamizato
    Department of Anesthesiology, Faculty of Medicine, University of the Ryukyus, Okinawa 903 0215
    Masui 61:1362-5. 2012
    The fentanyl infusion rate was controlled by employing a target controlled infusion (TCI) technique under anticoagulant therapy for postoperative pain management...

Research Grants63

  1. Modeling TH17 Cells in Acute GVHD
    JONATHAN STUART SERODY; Fiscal Year: 2010
    ..MHC disparities found on antigen-presenting cells in the host, which activate donor T cells via a presumed Th1/Tc1 pathway...
  2. JONATHAN STUART SERODY; Fiscal Year: 2016
    ..Previous work had suggested that GvHD was mediated by Th1/Tc1 T cells, although conflicting data using mice unable to generate or respond to IFN-? has been published...
  3. Role of C/EBPepsilon in myeloid differentiation
    Stephanie Halene; Fiscal Year: 2010
    ..The appearance of the secondary granule proteins (SGP) lactoferrin (LF), transcobalamin I (TCI), neutrophil collagenase (NC) and neutrophil gelatinase (NG) marks the commitment to terminal neutrophil ..
  4. Mary L Disis; Fiscal Year: 2014
    ..We will also assess whether these culture methods increase epitope spreading. ..
  5. CXCL16 as a therapeutic target for atherosclerosis
    Shuhua Han; Fiscal Year: 2010
    ..The receptor for CXCL16, CXCR6, is preferentially expressed by Th1 or Tc1 cells and is a differential marker of polarized Th1 cells...
  6. STRUCTURAL BASIS OF VITAMIN B12 (COBALAMIN) DEFICIENCY
    Heidi Schubert; Fiscal Year: 2002
    ..3) Produce a model of intrinsic factor (IF), haptocorrin and transcobalamin I (TCI) based on the high amino acid sequence identity with TCII.
  7. PAUL CAMILLE TUMEH; Fiscal Year: 2015
    ..vaccine delivery system that will topically co- deliver antigen/adjuvant for transcutaneous immunization (TCI)...
  8. Quiescent Tc17 programmed CD8 T cells and their role in graft versus host disease
    CAMERON JOHN TURTLE; Fiscal Year: 2012
    ..in the type 17 programmed pool that maintain regulation of TCR signaling or differentiation into IFN-3 secreting Tc1-like effector cells that are no longer restrained by TCR regulation...
  9. CAMERON JOHN TURTLE; Fiscal Year: 2015
    ..17 programmed pool that maintain regulation of TCR signaling or differentiation into IFN-[unreadable] secreting Tc1-like effector cells that are no longer restrained by TCR regulation...
  10. Christopher M Walker; Fiscal Year: 2016
    ..associated with changes in plasma cytokines and other pregnancy-related immunoregulatory molecules that promote Th1/Tc1 immunity...
  11. Aaron P Rapoport; Fiscal Year: 2014
    ..were stimulated by artificial antigen presenting cells under conditions that promote central memory cells and Th1/Tc1 function...
  12. Richard S Blumberg; Fiscal Year: 2016
    ..In Aim 2, we will determine how FcRn-mediated routing of IgG IC within DC leads to the establishment of Th1 and Tc1 effectors responses within the gut...
  13. Regulators of Osteoblast Protein Synthesis Initiation
    THOMAS LEO MCCARTHY; Fiscal Year: 2013
    ..During studies to reconstruct this process, we produced unique evidence for a potent ternary complex inhibitor (TCI) in the low molecular mass pool of eukaryotic RNA (sRNA)...
  14. Jay K Kolls; Fiscal Year: 2016
    ..Clearance of PC is mediated by augmented lung recruitment of CD8+ T cells, which have a Tc1-like phenotype (as defined by strong endogenous IFN production)...
  15. VINCENT ROBERT BONAGURA; Fiscal Year: 2014
    ..ligation of their AHR, can become HPV-specific TH1-like T-cells that can support the generation of cytotoxic TC1-like T-cells...
  16. T CELL MEMORY TO PATHOGENS: GENERATION AND FUNCTION
    Susan L Swain; Fiscal Year: 2013
    ..cells that their preliminary data show plays a key role in protection against influenza, and compare these Tc17 to Tc1 subsets and define their function and protective abilities and mechanisms of action...
  17. Stephania Cormier; Fiscal Year: 2016
    ..e. increased IL10 and Treg cells and decreased Th1, Tc1, and Th17 cell numbers) and not protective...
  18. Vijay K Kuchroo; Fiscal Year: 2016
    ..provided by applicant): In 2002, we cloned Tim-3 as a molecule differentially expressed of IFN?-producing Th1/Tc1 cells. However, we have found that Tim-3 is also expressed on pro-inflammatory Th17 cells...
  19. Pierre Buekens; Fiscal Year: 2014
    DESCRIPTION (provided by investigator): T. cruzi has been divided into two main lineages: T. cruzi I (TcI) and T. cruzi II (TcII)...
  20. Binfeng Lu; Fiscal Year: 2014
    ..We hypothesize that the expression of immunological "danger signal" IL-33 in the tumor environment promotes Tc1 immune responses against cancer. Following aims are proposed to test this hypothesis: Specific Aim 1...
  21. ANDREW THOMPSON TAYLOR; Fiscal Year: 2016
    ..We hypothesize that ligands based on the relatively new {Tc1(C0)3} core and structural analogues of the Al18FNODA-butyric acid complex offer the best avenue for continued ..
  22. Earnestine Willis; Fiscal Year: 2015
    ..CHIMC-Take Control IMMUNIZES! (CHIMC-TCI) will be developed to disseminate findings and to facilitate adoption of CBPR approaches for a larger population...
  23. Translational Hematology and Oncology Research Laboratory Expansion Project
    Jaroslaw P Maciejewski; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): In the last decade the Cleveland Clinic Taussig Cancer Institute (TCI) has demonstrated tremendous growth in terms of cancer care, clinical trials and translational cancer research...
  24. CHRISTOPHER BRYCE JOHNSON; Fiscal Year: 2016
    ..Priming CD8+ tumor-reactive T cells in the presence of IL-12 polarizes cells to a Tc1 phenotype...
  25. Targeting pDCs for the Generation of Effective Anti-HCV CD8+ T-Cell Immunity
    John Connolly; Fiscal Year: 2009
    ..adjuvant-based pDC targeting constructs We will 1) Generate fusion proteins of anti-BDCA2 and the immunodominant TC1 viral epitopes identified in Aim 2...
  26. Thomas Pertel; Fiscal Year: 2014
    ..provided by applicant): We cloned Tim-3 as a molecule differentially expressed on IFN-gamma producing Th1/Tc1 cells and more recently found that Tim-3 is also expressed on pathogenic pro-inflammatory Th17 cells...
  27. VISUALIZING DIABETIC FEET TO OPTIMIZE ORTHOTIC FITTING
    Michael Mueller; Fiscal Year: 2006
    ..The goal of Aim 1 is to determine the effect of a total contact insert (TCI), a metatarsal pad, and metatarsal pad placement on forefoot plantar pressures and soft tissue deformation...
  28. FACTORS REGULATING TRANSPOSITION IN C. ELEGANS
    John Collins; Fiscal Year: 1992
    ..and molecular approaches will be combined to investigate important features of four C elegans transposon families: Tc1, Tc3, Tc4, and Tc5...
  29. 800 MHz Triple Resonance Observe (TXO) Detection CryoProbe
    Gerhard Wagner; Fiscal Year: 2010
    ..cryoprobe accessory with one cryoplatform and two triple-resonance cryoprobes that are optimized for 1H detection (TCI), which will be the work horse for 3D ad 4D dispersed NOESY experiments, and a 13C/15N detection optimized probe, ..
  30. A Multicomponent Anthrax Vaccine using Phage T4 Display
    VENIGALLA RAO; Fiscal Year: 2007
    ..Three novel platform technologies, needle-free skin patch transcutaneous immunization (TCI), phage T4 multicomponent display, and liposome and emulsion adjuvant formulations, will be brought to bear on ..
  31. Asthma Induction by Dendritic Cells and Th2 Cells
    Sun Sang Sung; Fiscal Year: 2007
    ..In the lung but not lymph nodes of lung-immunized mice, large numbers of interferon-gamma-producing CD8+ T cells (Tc1) were present, resulting in a more Th2-baised environment in the lungs...
  32. Nanocarriers for transcutaneous delivery of vaccines
    John Clements; Fiscal Year: 2009
    ..One such approach, transcutaneous immunization (TCI), is a non-invasive, safe method of delivering antigens directly onto bare skin...
  33. Transcutaneous Immunization for an Anthrax Vaccine
    Richard Kenney; Fiscal Year: 2003
    Transcutaneous Immunization (TCI) is a novel, painless, and noninvasive (skin patch) method of vaccination...
  34. Glioma Immunotherapy Usingengineered T-Cells
    Michael Jensen; Fiscal Year: 2006
    ..CTL's retain IL13Ralpha-specific anti-glioma cytolytic activity as well as chimeric immunoreceptor regulated Tc1 cytokine secretion and proliferation in vitro, and, mediate the in vivo regression of established human ..
  35. STRUCTURE/FUNCTION OF EFF-2 KINASE
    ALEXEY RYAZANOV; Fiscal Year: 2003
    ..of eEF-2 kinase gene inactivation on phenotype and overall developmental pattern using three different approaches: Tc1 mutagenesis, deletion mutagenesis with rescue by plasmid transgenics, and an antisense approach...
  36. TRANSCUTANEOUS IMMUNIZATION FOR DNA
    Gregory Glenn; Fiscal Year: 1999
    ..this proposal is to evaluate the potential for delivering DNA vaccines via transcutaneous immunization technology (TCI)...
  37. HEPATIC LESIONS IN MURINE CHRONIC GRAFT VS HOST DISEASE
    John Vierling; Fiscal Year: 2001
    ..and functions of T cells isolated from inflamed portal tracts during evolution of NSDC we will assess: a) Th1/Tc1 versus Th2/Tc2 cytokine phenotypes of CD4/CD8 T cells during evolution of NSDC by flow cytometry; b) ..
  38. NORTHERN NEW JERSEY COMMUNITY CLINICAL ONCOLOGY PROGRAM
    Richard Rosenbluth; Fiscal Year: 2006
    ..Hackensack University Medical Center (HUMC) includes a pediatric program, Tomorrows Children?s Institute (TCI) and an adult program, the Northern New Jersey Cancer Center (NNJCC)...
  39. TRANSCUTANEOUS IMMUNIZATION FOR TETANUS BOOSTER
    Gregory Glenn; Fiscal Year: 1999
    DESCRIPTION: (Adapted from Applicant's Abstract) Transcutaneous immunization (TCI), the introduction of antigens using an application to intact skin, is a new technology that could decrease the complications associated with the use of ..
  40. ANALYSIS OF CD8 T CELL RESPONSES TO TUMORS
    Richard Dutton; Fiscal Year: 2009
    ..Adoptively transferred in vitro generated Tc1 or Td2 CDS effectors from tumor specific T cell receptor transgenic mice can eliminate established tumors in ..
  41. Novel Delivery of a New Vaccine for Tuberculosis
    DIANE PEREIRA; Fiscal Year: 2003
    ..This application proposes to investigate the ability of a transcutaneous immunization (TCI) to deliver this vaccine formulation to mice...
  42. TRANSPOSABLE GENETIC ELEMENTS OF THE NEMATODE
    R Anderson; Fiscal Year: 1993
    ..Genetic activity of the transposable element Tc1, contained in the nematode Caenorhabditis elegans, is subject to both strain-specific and tissue-specific ..
  43. TC1 AND TC2 ACTIVITY IN MALIGNANCY
    Patrick Flood; Fiscal Year: 1999
    ..By similarities with Th1 and Th2 subsets of CD4, the CD8+ T-cell subsets have been designated as Tc1 and Tc2. This division was made on the basis of the cytokines they produce...
  44. Immunobiology of Antigen Presenting Cells in Vivo
    Kenneth Rock; Fiscal Year: 2006
    ..that stimulation of naive T cells by different APC will lead different outcomes: Tolerance versus response, TH1/TC1 versus TH2/TC2 effector cells, and/or the generation of memory...
  45. RFLP-MAPPING OF QTLS FOR LIFE SPAN AND LIFE HISTORY
    Thomas Johnson; Fiscal Year: 1993
    ..We intend to focus especially on those RFLPs generated by transposable elements (Tc1 and Tc2)...
  46. PATHOGENIC MECHANISMS IN AUTOIMMUNITY
    Leonard Chess; Fiscal Year: 1999
    ..He will utilize two AF-1transgenics to explore the biology of AF-1 in the differentiation of TH1 and TC1 subsets in normal animals and in animals with experimental allergic encephalomyelitis (EAE). In project #2, Dr...
  47. PRIMARY STIMULATION OF HUMAN CD8+ T LYMPHOCYTES
    David Lee; Fiscal Year: 2001
    ..of T cell markers (CD45RA, CD62L), (b) proliferation, and the differentiation of (c) cytotoxic responses and (d) TC1 (IFN-gamma and IL-2) vs. TC2 (IL-4 and IL-5) cytokine production profiles. Aim 2...
  48. CYTOTOXIC CELLS AND ALLOIMMUNE RESPONSES
    Dwain Thiele; Fiscal Year: 2004
    ..In addition, dramatically increased expansion of Tc1 cytokine producing CD8+ T cells is observed after transfer of perforin deficient CD8+ T cells but not after ..
  49. LEUKEMIA THERAPY WITH MIHA SPECIFIC T CELLS
    Wei Chen; Fiscal Year: 2002
    ..2. To assess the therapeutic efficacy, toxicity and mechanisms of donor CD8+ Tc1 and Tc2 specific for host hematopoietic tissue-restricted MiHA. 3...
  50. Non-Invasive Imaging of T Cell Trafficking
    Bernd Pichler; Fiscal Year: 2006
    ..Cutaneous DTHR are mediated by Interferon gamma producing CD4+ (Th1) and CD8+ (Tc1) cells that protect against intracellular pathogens or develop therapeutic effects when directed against tumor ..
  51. TRANSCUTANEOUS IMMUNIZATION FOR ENTERIC VACCINES
    TANYA SCHARTON KERSTEN; Fiscal Year: 1999
    Transcutaneous immunization (TCI) is a novel immunization strategy in which vaccine antigens are placed on the intact skin...
  52. Synaptic Damage and Plasticity After Brain Ischemia
    Bingren Hu; Fiscal Year: 2006
    ..project is to investigate molecular mechanisms of synaptic damage and plasticity after transient cerebral ischemia (TCI). TCI selectively causes delayed neuronal death and leads to neurological deficits...
  53. RESPONSES TO RSV AND ALLERGENS AS ANTECEDENTS OF ASTHMA
    Marilyn Halonen; Fiscal Year: 2002
    ..the temporal patterns in and mechanisms of development of mitogen and RSV-specific T cytotoxic cell subsets (CD8+ Tc1 and Tc2) and mitogen and Alt-specific T helper cell subsets (CD4+ Th1 and Th2); 2) to determine the immune ..
  54. IMPACT OF EPITOPE DENSITY ON TCD8, ACTIVATION AND MEMORY
    Laurence Eisenlohr; Fiscal Year: 2003
    ..He expects that, for all but the highest epitope densities, responses will be TC1 (interferon-g-producing). 3) The number of TCD8+ entering the memory pool...
  55. 600 MHz NMR and Probes for Shared Use
    John Flanagan; Fiscal Year: 2006
    ..institutional commitment is provide in the form of COM funds to purchase a 1H, 13C, {15N} inverse triple resonance TCI cryoprobe, 100% salary support for three years and 50% salary support thereafter for the recently hired NMR ..
  56. Bruker 800 MHz TCI CryoProbe
    ROBERT CLUBB; Fiscal Year: 2006
    ..It will significantly improve the sensitivity of the Center's single 800 MHz spectrometer enabling a greater number of projects to benefit from access to this high-field instrument. [unreadable] [unreadable]..
  57. ZEBRAFISH AS A MODEL SYSTEM FOR BIOMEDICAL RESEARCH
    PERRY HACKETT; Fiscal Year: 1999
    ..to creating a transgenic vertebrate by employing a short inverted repeat type transposable element of the mariner/Tc1 superfamily of elements...
  58. Mammalian Lactoferrin Receptors: Structure and Function
    Bo Lonnerdal; Fiscal Year: 2007
    ..Overall, our understanding of the physiological significance of Lf and its receptor will be increased. ..
  59. SINGLE CELL ANALYSIS OF T CELL IMMUNITY IN HIV
    Magdalena Tary Lehmann; Fiscal Year: 2004
    ..hypothesis, that cytokine expressed by human T cells is much more highly regulated than predicted by the Th1/Th2, Tc1/Tc2 model (Aim 3)...
  60. SUBTLE DISTURBANCES OF COBALAMIN STATUS
    Ralph Carmel; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  61. Transcutaneous Immunization for an Anthrax Vaccine
    Gregory Glenn; Fiscal Year: 2005
    ....