TLR4

Summary

Gene Symbol: TLR4
Description: toll like receptor 4
Alias: ARMD10, CD284, TLR-4, TOLL, toll-like receptor 4, hToll, homolog of Drosophila toll
Species: human
Products:     TLR4

Top Publications

  1. Minoretti P, Gazzaruso C, Vito C, Emanuele E, Bianchi M, Coen E, et al. Effect of the functional toll-like receptor 4 Asp299Gly polymorphism on susceptibility to late-onset Alzheimer's disease. Neurosci Lett. 2006;391:147-9 pubmed
    Experimental data have shown an upregulated expression of toll-like receptors, particularly toll-like receptor 4 (TLR4), in neurodegeneration...
  2. Pasini A, Anselmi M, Garbin U, Franchi E, Stranieri C, Nava M, et al. Enhanced levels of oxidized low-density lipoprotein prime monocytes to cytokine overproduction via upregulation of CD14 and toll-like receptor 4 in unstable angina. Arterioscler Thromb Vasc Biol. 2007;27:1991-7 pubmed
    ..oxidized low-density lipoprotein (oxLDL) contributes to cytokine overproduction via upregulation of CD14 and toll-like receptor-4 (TLR-4) expression on circulating monocytes of unstable angina (UA) patients...
  3. Rallabhandi P, Bell J, Boukhvalova M, Medvedev A, Lorenz E, Arditi M, et al. Analysis of TLR4 polymorphic variants: new insights into TLR4/MD-2/CD14 stoichiometry, structure, and signaling. J Immunol. 2006;177:322-32 pubmed
    b>TLR4 is the signal-transducing receptor for structurally diverse microbial molecules such as bacterial LPS, respiratory syncytial virus fusion (F) protein, and chlamydial heat shock protein 60...
  4. Azzam N, Nounou H, Alharbi O, Aljebreen A, Shalaby M. CARD15/NOD2, CD14 and toll-like 4 receptor gene polymorphisms in Saudi patients with Crohn's Disease. Int J Mol Sci. 2012;13:4268-80 pubmed publisher
    ..Polymorphisms in the CARD15/NOD2 gene, in addition to functional variants of the toll-like receptor-4 (TLR4) and CD14 genes, have been associated with the development of Crohn's disease...
  5. Muzio M, Natoli G, Saccani S, Levrero M, Mantovani A. The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6). J Exp Med. 1998;187:2097-101 pubmed
    The human homologue of Drosophila Toll (hToll) is a recently cloned receptor of the interleukin 1 receptor (IL-1R) superfamily, and has been implicated in the activation of adaptive immunity...
  6. Hawn T, Scholes D, Li S, Wang H, Yang Y, Roberts P, et al. Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women. PLoS ONE. 2009;4:e5990 pubmed publisher
    ..To test the hypothesis that polymorphisms in Toll-like receptor (TLR) pathway genes are associated with susceptibility to UTIs, we conducted a population-based case-..
  7. Nuolivirta K, Hurme M, Halkosalo A, Koponen P, Korppi M, Vesikari T, et al. Gene polymorphism of IFNG +874 T/A and TLR4 +896 A/G and recurrent infections and wheezing in toddlers with history of bronchiolitis. Pediatr Infect Dis J. 2009;28:1121-3 pubmed publisher
    Cytokine and TLR4 polymorphisms and their association with the infection history of 129 children hospitalized for bronchiolitis during the first 6 months of life were analyzed...
  8. Velez D, Wejse C, Stryjewski M, Abbate E, Hulme W, Myers J, et al. Variants in toll-like receptors 2 and 9 influence susceptibility to pulmonary tuberculosis in Caucasians, African-Americans, and West Africans. Hum Genet. 2010;127:65-73 pubmed publisher
    ..b>Toll-like receptor' (TLR) polymorphisms have been associated with regulation of TLR expression and development of active ..
  9. Brett P, Zygogianni P, Griffiths G, Tomaz M, Parkar M, D Aiuto F, et al. Functional gene polymorphisms in aggressive and chronic periodontitis. J Dent Res. 2005;84:1149-53 pubmed
    ..These results suggest that there are in fact both shared and unique genetic associations in aggressive and chronic periodontitis. ..
  10. Awomoyi A, Rallabhandi P, Pollin T, Lorenz E, Sztein M, Boukhvalova M, et al. Association of TLR4 polymorphisms with symptomatic respiratory syncytial virus infection in high-risk infants and young children. J Immunol. 2007;179:3171-7 pubmed
    ..RSV fusion (F) protein activates cells through TLR4. Two single nucleotide polymorphisms (SNPs) encoding Asp299Gly and Thr399Ile substitutions in the TLR4 ectodomain ..

Detail Information

Publications62

  1. Minoretti P, Gazzaruso C, Vito C, Emanuele E, Bianchi M, Coen E, et al. Effect of the functional toll-like receptor 4 Asp299Gly polymorphism on susceptibility to late-onset Alzheimer's disease. Neurosci Lett. 2006;391:147-9 pubmed
    Experimental data have shown an upregulated expression of toll-like receptors, particularly toll-like receptor 4 (TLR4), in neurodegeneration...
  2. Pasini A, Anselmi M, Garbin U, Franchi E, Stranieri C, Nava M, et al. Enhanced levels of oxidized low-density lipoprotein prime monocytes to cytokine overproduction via upregulation of CD14 and toll-like receptor 4 in unstable angina. Arterioscler Thromb Vasc Biol. 2007;27:1991-7 pubmed
    ..oxidized low-density lipoprotein (oxLDL) contributes to cytokine overproduction via upregulation of CD14 and toll-like receptor-4 (TLR-4) expression on circulating monocytes of unstable angina (UA) patients...
  3. Rallabhandi P, Bell J, Boukhvalova M, Medvedev A, Lorenz E, Arditi M, et al. Analysis of TLR4 polymorphic variants: new insights into TLR4/MD-2/CD14 stoichiometry, structure, and signaling. J Immunol. 2006;177:322-32 pubmed
    b>TLR4 is the signal-transducing receptor for structurally diverse microbial molecules such as bacterial LPS, respiratory syncytial virus fusion (F) protein, and chlamydial heat shock protein 60...
  4. Azzam N, Nounou H, Alharbi O, Aljebreen A, Shalaby M. CARD15/NOD2, CD14 and toll-like 4 receptor gene polymorphisms in Saudi patients with Crohn's Disease. Int J Mol Sci. 2012;13:4268-80 pubmed publisher
    ..Polymorphisms in the CARD15/NOD2 gene, in addition to functional variants of the toll-like receptor-4 (TLR4) and CD14 genes, have been associated with the development of Crohn's disease...
  5. Muzio M, Natoli G, Saccani S, Levrero M, Mantovani A. The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6). J Exp Med. 1998;187:2097-101 pubmed
    The human homologue of Drosophila Toll (hToll) is a recently cloned receptor of the interleukin 1 receptor (IL-1R) superfamily, and has been implicated in the activation of adaptive immunity...
  6. Hawn T, Scholes D, Li S, Wang H, Yang Y, Roberts P, et al. Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women. PLoS ONE. 2009;4:e5990 pubmed publisher
    ..To test the hypothesis that polymorphisms in Toll-like receptor (TLR) pathway genes are associated with susceptibility to UTIs, we conducted a population-based case-..
  7. Nuolivirta K, Hurme M, Halkosalo A, Koponen P, Korppi M, Vesikari T, et al. Gene polymorphism of IFNG +874 T/A and TLR4 +896 A/G and recurrent infections and wheezing in toddlers with history of bronchiolitis. Pediatr Infect Dis J. 2009;28:1121-3 pubmed publisher
    Cytokine and TLR4 polymorphisms and their association with the infection history of 129 children hospitalized for bronchiolitis during the first 6 months of life were analyzed...
  8. Velez D, Wejse C, Stryjewski M, Abbate E, Hulme W, Myers J, et al. Variants in toll-like receptors 2 and 9 influence susceptibility to pulmonary tuberculosis in Caucasians, African-Americans, and West Africans. Hum Genet. 2010;127:65-73 pubmed publisher
    ..b>Toll-like receptor' (TLR) polymorphisms have been associated with regulation of TLR expression and development of active ..
  9. Brett P, Zygogianni P, Griffiths G, Tomaz M, Parkar M, D Aiuto F, et al. Functional gene polymorphisms in aggressive and chronic periodontitis. J Dent Res. 2005;84:1149-53 pubmed
    ..These results suggest that there are in fact both shared and unique genetic associations in aggressive and chronic periodontitis. ..
  10. Awomoyi A, Rallabhandi P, Pollin T, Lorenz E, Sztein M, Boukhvalova M, et al. Association of TLR4 polymorphisms with symptomatic respiratory syncytial virus infection in high-risk infants and young children. J Immunol. 2007;179:3171-7 pubmed
    ..RSV fusion (F) protein activates cells through TLR4. Two single nucleotide polymorphisms (SNPs) encoding Asp299Gly and Thr399Ile substitutions in the TLR4 ectodomain ..
  11. Paulus S, Hirschfeld A, Victor R, Brunstein J, Thomas E, Turvey S. Common human Toll-like receptor 4 polymorphisms--role in susceptibility to respiratory syncytial virus infection and functional immunological relevance. Clin Immunol. 2007;123:252-7 pubmed
    Evidence suggests that Toll-like receptor 4 (TLR4) contributes to immune recognition of respiratory syncytial virus (RSV). The TLR4 gene harbours a polymorphism-Asp299Gly-previously associated with reduced TLR4 signalling...
  12. de Ridder L, Weersma R, Dijkstra G, van der Steege G, Benninga M, Nolte I, et al. Genetic susceptibility has a more important role in pediatric-onset Crohn's disease than in adult-onset Crohn's disease. Inflamm Bowel Dis. 2007;13:1083-92 pubmed
    ..R702W, G908R, and 3020insC of CARD15 (caspase activating recruitment domain 15); Asp299Gly and Thr399Ile of TLR4; -207G-->C, 1672C-->T (L503F), rs3792876, rs274551, rs272893, and rs273900 of SLC22A4/5; and 113G-->A as ..
  13. Carvalho A, Pasqualotto A, Pitzurra L, Romani L, Denning D, Rodrigues F. Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis. J Infect Dis. 2008;197:618-21 pubmed publisher
    b>Toll-like receptors (TLRs) are important components of innate immunity. We investigated the association between polymorphisms in the TLR2, TLR4, and TLR9 genes and susceptibility to noninvasive forms of pulmonary aspergillosis...
  14. Choi S, Wiesner P, Almazan F, Kim J, Miller Y. Spleen tyrosine kinase regulates AP-1 dependent transcriptional response to minimally oxidized LDL. PLoS ONE. 2012;7:e32378 pubmed publisher
    ..We have demonstrated that minimally oxidized LDL (mmLDL) binds to CD14 and mediates TLR4/MD-2-dependent responses in macrophages, many of which are MyD88-independent...
  15. Chang Y, Wu M, Lin J, Sheu B, Muta T, Inoue H, et al. Induction of cyclooxygenase-2 overexpression in human gastric epithelial cells by Helicobacter pylori involves TLR2/TLR9 and c-Src-dependent nuclear factor-kappaB activation. Mol Pharmacol. 2004;66:1465-77 pubmed
    ..We explored a novel NF-kappaB activation pathway. The mutants of TLR2 and TLR9, but not TLR4, inhibited H. pylori-induced COX-2 promoter activity, and neutralizing antibodies for TLR2 and TLR9 abolished H...
  16. Uno K, Kato K, Atsumi T, Suzuki T, Yoshitake J, Morita H, et al. Toll-like receptor (TLR) 2 induced through TLR4 signaling initiated by Helicobacter pylori cooperatively amplifies iNOS induction in gastric epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2007;293:G1004-12 pubmed
    Cell-surface Toll-like receptors (TLRs) initiate innate immune responses, such as inducible nitric oxide synthase (iNOS) induction, to microorganisms' surface pathogens...
  17. Etokebe G, Knezevic J, Petricevic B, Pavelic J, Vrbanec D, Dembic Z. Single-nucleotide polymorphisms in genes encoding toll-like receptor -2, -3, -4, and -9 in case-control study with breast cancer. Genet Test Mol Biomarkers. 2009;13:729-34 pubmed publisher
    ..Single-nucleotide polymorphisms (SNPs) of Toll-like receptor (TLR) 2, TLR3, TLR4, and TLR9 genes, which are important for innate immunity, were analyzed for the association with breast cancer...
  18. Nieters A, Beckmann L, Deeg E, Becker N. Gene polymorphisms in Toll-like receptors, interleukin-10, and interleukin-10 receptor alpha and lymphoma risk. Genes Immun. 2006;7:615-24 pubmed
    ..43-5.59) and a decreased risk of chronic lymphocytic leukaemia (OR=0.61, 95% CI=0.38-0.95). Furthermore, the TLR4 Asp299Gly variant was positively associated with the risk of mucosa-associated lymphoid tissue lymphoma (OR=2...
  19. Mansell A, Brint E, Gould J, O Neill L, Hertzog P. Mal interacts with tumor necrosis factor receptor-associated factor (TRAF)-6 to mediate NF-kappaB activation by toll-like receptor (TLR)-2 and TLR4. J Biol Chem. 2004;279:37227-30 pubmed
    The Toll-interleukin-1 receptor domain-containing adapter Mal (MyD88 adapter-like protein) is involved in Toll-like receptor (TLR)-2 and TLR4 signal transduction...
  20. Sanchez E, Orozco G, Lopez Nevot M, Jimenez Alonso J, Martin J. Polymorphisms of toll-like receptor 2 and 4 genes in rheumatoid arthritis and systemic lupus erythematosus. Tissue Antigens. 2004;63:54-7 pubmed
    ..polymorphism method, the possible association between the polymorphisms of TLR2 (Arg677Trp and Arg753Gln) and TLR4 (Asp299Gly and Thr399Ile) genes with the susceptibility or severity of RA and SLE...
  21. Akil I, Ozkinay F, Onay H, Canda E, Gumuser G, Kavukcu S. Assessment of Toll-like receptor-4 gene polymorphism on pyelonephritis and renal scar. Int J Immunogenet. 2012;39:303-7 pubmed publisher
    The aim of this study was to evaluate the effect of the TLR-4 gene TLR4 c.896A < G polymorphism on the development and clinical severity of urinary tract infections (UTI) and renal scar formations in children...
  22. Tal G, Mandelberg A, Dalal I, Cesar K, Somekh E, Tal A, et al. Association between common Toll-like receptor 4 mutations and severe respiratory syncytial virus disease. J Infect Dis. 2004;189:2057-63 pubmed
    ..Toll-like receptor 4 (TLR4) and CD14 are part of a receptor complex involved in the innate immune response to RSV...
  23. Rehli M, Poltorak A, Schwarzfischer L, Krause S, Andreesen R, Beutler B. PU.1 and interferon consensus sequence-binding protein regulate the myeloid expression of the human Toll-like receptor 4 gene. J Biol Chem. 2000;275:9773-81 pubmed
    ..In mice, destructive mutations of Tlr4 impede the normal response to LPS and cause a high susceptibility to Gram-negative infection...
  24. Horie Y, Meguro A, Ota M, Kitaichi N, Katsuyama Y, Takemoto Y, et al. Association of TLR4 polymorphisms with Behcet's disease in a Korean population. Rheumatology (Oxford). 2009;48:638-42 pubmed publisher
    ..We recently reported that another gene, Toll-like receptor-4 (TLR4) is also implicated in BD in a Japanese population...
  25. Qadri Q, Rasool R, Afroze D, Naqash S, Gulzar G, Yousuf A, et al. Study of TLR4 and IL-8 gene polymorphisms in H.pylori-induced inflammation in gastric cancer in an ethnic Kashmiri population. Immunol Invest. 2014;43:324-36 pubmed publisher
    ..DNA extraction was followed by PCR detection of H. pylori infection, PCR-RFLP for the TLR 4 polymorphism and PCR-CTPP for IL-8 gene polymorphism. The adjusted OR for gastric cancer risk was 1.15 (95% CI, 0...
  26. Theodoropoulos G, Saridakis V, Karantanos T, Michalopoulos N, Zagouri F, Kontogianni P, et al. Toll-like receptors gene polymorphisms may confer increased susceptibility to breast cancer development. Breast. 2012;21:534-8 pubmed publisher
    b>Toll-like receptor (TLR) activation may be an important event in tumor cell immune evasion. TLR2 and TLR4 gene polymorphisms have been related to increased susceptibility to cancer development in various organs...
  27. Lysakova Devine T, Keogh B, Harrington B, Nagpal K, Halle A, Golenbock D, et al. Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor molecule. J Immunol. 2010;185:4261-71 pubmed publisher
    ..We have identified an 11-aa-long peptide from A46 (termed viral inhibitor peptide of TLR4, or VIPER), which, when fused to a cell-penetrating delivery sequence, potently inhibits TLR4-mediated responses...
  28. Vabulas R, Ahmad Nejad P, Ghose S, Kirschning C, Issels R, Wagner H. HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway. J Biol Chem. 2002;277:15107-12 pubmed
    ..Using the system of genetic complementation with Toll-like receptors (TLR) we found that TLR2 and TLR4 confer responsiveness to HSP70 in 293T fibroblasts...
  29. Mrazek F, Gallo J, Stahelova A, Petrek M. Coding variants of TLR2 and TLR4 genes do not substantially contribute to prosthetic joint infection. Inflamm Res. 2013;62:483-7 pubmed publisher
    ..We conducted a genetic association study that investigated whether selected coding variants of the genes for Toll-like receptors (TLR)2 and TLR4 may contribute to genetic susceptibility for PJI...
  30. Bosisio D, Polentarutti N, Sironi M, Bernasconi S, Miyake K, Webb G, et al. Stimulation of toll-like receptor 4 expression in human mononuclear phagocytes by interferon-gamma: a molecular basis for priming and synergism with bacterial lipopolysaccharide. Blood. 2002;99:3427-31 pubmed
    In human monocytes and macrophages, interferon-gamma (IFNgamma) augmented mRNA and surface expression of toll-like receptor 4 (TLR4), a crucial component of the signaling receptor complex for bacterial lipopolysaccharide (LPS)...
  31. Tahara T, Arisawa T, Shibata T, Hirata I, Nakano H. Association of polymorphism of TLR4 and CD14 genes with gastroduodenal diseases in Japan. Inflammopharmacology. 2007;15:124-8 pubmed
    ..b>Toll like receptor 4(TLR4) and CD14-mediated recognition of lipo-polysaccharide (LPS) is required for efficient recognition of ..
  32. Brightbill H, Libraty D, Krutzik S, Yang R, Belisle J, Bleharski J, et al. Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science. 1999;285:732-6 pubmed
    ..lipoproteins are potent stimulators of IL-12 production by human macrophages, and that induction is mediated by Toll-like receptors (TLRs)...
  33. Hirata T, Osuga Y, Hamasaki K, Hirota Y, Nose E, Morimoto C, et al. Expression of toll-like receptors 2, 3, 4, and 9 genes in the human endometrium during the menstrual cycle. J Reprod Immunol. 2007;74:53-60 pubmed
    Innate immunity in the endometrium has fundamental significance for reproduction. Although toll-like receptors (TLRs) play central roles in innate immune responses, their expression in the human endometrium remains to be fully elucidated...
  34. da Silva Correia J, Soldau K, Christen U, Tobias P, Ulevitch R. Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2. J Biol Chem. 2001;276:21129-35 pubmed
    ..Examples include members of the Drosophila Toll (dToll) and the mammalian Toll-like receptor (TLR) protein families...
  35. Illig T, Bongardt F, Schöpfer A, Holle R, Müller S, Rathmann W, et al. The endotoxin receptor TLR4 polymorphism is not associated with diabetes or components of the metabolic syndrome. Diabetes. 2003;52:2861-4 pubmed