TLR7

Summary

Gene Symbol: TLR7
Description: toll like receptor 7
Alias: TLR7-like, toll-like receptor 7, toll-like receptor 7-like
Species: human

Top Publications

  1. ncbi Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides
    Veit Hornung
    Department of Internal Medicine, Division of Clinical Pharmacology, University of Munich, Munich, Germany
    J Immunol 168:4531-7. 2002
  2. doi Association of TLR7 copy number variation with susceptibility to childhood-onset systemic lupus erythematosus in Mexican population
    Humberto García-Ortiz
    Genomic of Complex Diseases Laboratory, Instituto Nacional de Medicina Genomica, Mexico City, Mexico
    Ann Rheum Dis 69:1861-5. 2010
  3. pmc TLR1/2, TLR7, and TLR9 signals directly activate human peripheral blood naive and memory B cell subsets to produce cytokines, chemokines, and hematopoietic growth factors
    Sudhanshu Agrawal
    Division of Basic and Clinical Immunology, Medical Sciences I, C 240, University of California, Irvine, CA 92697, USA
    J Clin Immunol 31:89-98. 2011
  4. doi Expression of Toll-like receptor 3 and Toll-like receptor 7 in muscle is characteristic of inflammatory myopathy and is differentially regulated by Th1 and Th17 cytokines
    A Tournadre
    University of Lyon, Edouard Herriot Hospital, Lyon, France
    Arthritis Rheum 62:2144-51. 2010
  5. doi Toll-like receptor 7 and 9 expression in peripheral blood mononuclear cells from patients with chronic hepatitis B and related hepatocellular carcinoma
    Ning Xu
    Key Laboratory of Health Ministry, Institute of Infectious Diseases, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310031, China
    Acta Pharmacol Sin 29:239-44. 2008
  6. doi The involvement of hypoxia-inducible factor 1 alpha in Toll-like receptor 7/8-mediated inflammatory response
    Sally A Nicholas
    Medway School of Pharmacy, University of Kent, Kent ME4 4TB, UK
    Cell Res 19:973-83. 2009
  7. ncbi Expression of toll-like receptors and type 1 interferon specific protein MxA in biliary atresia
    Ying Hsien Huang
    Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center and the Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Kaohsiung, Taiwan, ROC
    Lab Invest 87:66-74. 2007
  8. ncbi The bacterium, nontypeable Haemophilus influenzae, enhances host antiviral response by inducing Toll-like receptor 7 expression: evidence for negative regulation of host anti-viral response by CYLD
    Akihiro Sakai
    Department of Microbiology and Immunology, University of Rochester Medical Center, NY 14642, USA
    FEBS J 274:3655-68. 2007
  9. pmc Expressions of Toll-like receptors 3, 4, 7, and 9 in cervical lesions and their correlation with HPV16 infection in Uighur women
    Ayshamgul Hasimu
    Department of Pathology, Xinjiang Medical University, Urumqi, Xinjiang 830011, P R China
    Chin J Cancer 30:344-50. 2011
  10. pmc Toll-like receptor 7 mediates pruritus
    Tong Liu
    Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Neurosci 13:1460-2. 2010

Research Grants

  1. miR-155 regulation of cellular susceptibility to HIV-1 infection
    JULIO MARTIN-GARCIA; Fiscal Year: 2013
  2. Akiko Iwasaki; Fiscal Year: 2015
  3. STUART MICHAEL LEVITZ; Fiscal Year: 2016
  4. Carla M Cuda; Fiscal Year: 2016
  5. TLR7 mediates immune cell infiltration and homing to combat West Nile virus infec
    Fengwei Bai; Fiscal Year: 2010
  6. Yong Jun Liu; Fiscal Year: 2014
  7. Virus interference with Toll like Receptor Response on Dendritic Cells
    Elina I Zuniga; Fiscal Year: 2010
  8. Nina Bhardwaj; Fiscal Year: 2015
  9. Melissa Victoria Fernandez; Fiscal Year: 2014
  10. Inhibitors of Toll-like receptors 7 & 9 for treatment of skin inflammation
    FRANCK BARRAT; Fiscal Year: 2010

Detail Information

Publications261 found, 100 shown here

  1. ncbi Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides
    Veit Hornung
    Department of Internal Medicine, Division of Clinical Pharmacology, University of Munich, Munich, Germany
    J Immunol 168:4531-7. 2002
    ..High expression of TLR2 was characteristic for monocytes. PDC and B cells expressed marked levels of TLR7 and TLR9 and were directly sensitive to CpG ODN...
  2. doi Association of TLR7 copy number variation with susceptibility to childhood-onset systemic lupus erythematosus in Mexican population
    Humberto García-Ortiz
    Genomic of Complex Diseases Laboratory, Instituto Nacional de Medicina Genomica, Mexico City, Mexico
    Ann Rheum Dis 69:1861-5. 2010
    ..Recent studies have shown that Tlr7 gene dosage has a significant contribution in the autoimmune-enhancing effect in mouse models of systemic lupus ..
  3. pmc TLR1/2, TLR7, and TLR9 signals directly activate human peripheral blood naive and memory B cell subsets to produce cytokines, chemokines, and hematopoietic growth factors
    Sudhanshu Agrawal
    Division of Basic and Clinical Immunology, Medical Sciences I, C 240, University of California, Irvine, CA 92697, USA
    J Clin Immunol 31:89-98. 2011
    ..to direct and exclusive signaling provided by toll-like receptor (TLR) ligands Pam3CSK (TLR1/TLR2), Imiquimod (TLR7), and GpG-ODN2006 (TLR9)...
  4. doi Expression of Toll-like receptor 3 and Toll-like receptor 7 in muscle is characteristic of inflammatory myopathy and is differentially regulated by Th1 and Th17 cytokines
    A Tournadre
    University of Lyon, Edouard Herriot Hospital, Lyon, France
    Arthritis Rheum 62:2144-51. 2010
    ..To assess the expression of Toll-like receptor 3 (TLR-3) and TLR-7 in muscle tissue from patients with polymyositis (PM) and dermatomyositis (DM) and to investigate the function and regulation of TLR-3 in cultured muscle cells...
  5. doi Toll-like receptor 7 and 9 expression in peripheral blood mononuclear cells from patients with chronic hepatitis B and related hepatocellular carcinoma
    Ning Xu
    Key Laboratory of Health Ministry, Institute of Infectious Diseases, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310031, China
    Acta Pharmacol Sin 29:239-44. 2008
    ....
  6. doi The involvement of hypoxia-inducible factor 1 alpha in Toll-like receptor 7/8-mediated inflammatory response
    Sally A Nicholas
    Medway School of Pharmacy, University of Kent, Kent ME4 4TB, UK
    Cell Res 19:973-83. 2009
    ..b>TLR7/8 downstream signaling leads to a dramatic cellular stress associated with energy consumption...
  7. ncbi Expression of toll-like receptors and type 1 interferon specific protein MxA in biliary atresia
    Ying Hsien Huang
    Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center and the Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Kaohsiung, Taiwan, ROC
    Lab Invest 87:66-74. 2007
    ..These results show that there were significantly higher TLR7 and lower TLR3 and TLR9 mRNA expression in early stage of BA than in CC...
  8. ncbi The bacterium, nontypeable Haemophilus influenzae, enhances host antiviral response by inducing Toll-like receptor 7 expression: evidence for negative regulation of host anti-viral response by CYLD
    Akihiro Sakai
    Department of Microbiology and Immunology, University of Rochester Medical Center, NY 14642, USA
    FEBS J 274:3655-68. 2007
    ..bacterial pathogen, augments the host antiviral response by up-regulating epithelial Toll-like receptor 7 (TLR7) expression in vitro and in vivo...
  9. pmc Expressions of Toll-like receptors 3, 4, 7, and 9 in cervical lesions and their correlation with HPV16 infection in Uighur women
    Ayshamgul Hasimu
    Department of Pathology, Xinjiang Medical University, Urumqi, Xinjiang 830011, P R China
    Chin J Cancer 30:344-50. 2011
    ..the role of TLRs expression in cervical carcinogenesis in Uighur women, we detected the expressions of TLR3, TLR4, TLR7, and TLR9 in 25 normal cervical tissues, 64 cervical intraepithelial neoplasia (CIN) tissues, and 63 cervical ..
  10. pmc Toll-like receptor 7 mediates pruritus
    Tong Liu
    Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Neurosci 13:1460-2. 2010
    ..We found that functional Toll-like receptor 7 (TLR7) was expressed in C-fiber primary sensory neurons and was important for inducing itch (pruritus), but was not ..
  11. doi Toll-like receptors 7 and 8 expression is associated with poor outcome and greater inflammatory response in acute ischemic stroke
    David Brea
    Clinical Neuroscience Research Laboratory, Department of Neurology, Hospital Clinico Universitario, University of Santiago de Compostela, Santiago de Compostela, Spain
    Clin Immunol 139:193-8. 2011
    ..Infarct volume at 4-7 days was measured on Computed Tomography imaging. TLR7 and TLR8 at different time points were independently associated with poor outcome...
  12. doi Polymorphism in 3'-untranslated region of toll-like receptor 4 gene is associated with protection from hepatitis B virus recurrence after liver transplantation
    L Zhou
    Key Laboratory of Organ Transplantation, Zhejiang Province
    Transpl Infect Dis 13:250-8. 2011
    ..This study focused on the association between polymorphisms in the TLRs and HBV recurrence after liver transplantation in Han Chinese patients...
  13. pmc Activation of anti-hepatitis C virus responses via Toll-like receptor 7
    Jongdae Lee
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093 0663, USA
    Proc Natl Acad Sci U S A 103:1828-33. 2006
    ..Here we present evidence showing that a ligand of Toll-like receptor 7 (TLR7) can induce anti-HCV immunity not only by IFN induction, but also through an IFN-independent mechanism...
  14. ncbi The functional effects of physical interactions among Toll-like receptors 7, 8, and 9
    Jianyong Wang
    Department of Pharmacology, 3M Pharmaceutical Division, St Paul, Minnesota 55144, USA
    J Biol Chem 281:37427-34. 2006
    ..The other TLRs that are evolutionarily closely related and highly homologous are TLR7, TLR8, and TLR9...
  15. pmc Anti-HIV activity mediated by natural killer and CD8+ cells after toll-like receptor 7/8 triggering
    Erika Schlaepfer
    Division of Infectious Diseases and Hospital Epidemiology, Department of Internal Medicine, University Hospital of Zurich, Zurich, Switzerland
    PLoS ONE 3:e1999. 2008
    We previously found that triggering TLR7/8 either by single stranded HIV RNA or synthetic compounds induced changes in the lymphoid microenvironment unfavorable to HIV...
  16. doi Toll-like receptors 3 and 7 agonists enhance tumor cell lysis by human gammadelta T cells
    Hamed Shojaei
    Institute of Immunology, University Hospital Schleswig Holstein, Campus Kiel, Germany
    Cancer Res 69:8710-7. 2009
    ..cytotoxicity and granzyme A/B production were enhanced after pretreatment of tumor cells with TLR3 [poly(I:C)] or TLR7 ligand (imiquimod)...
  17. doi Multiplex screening of 22 single-nucleotide polymorphisms in 7 Toll-like receptors: an association study in rheumatoid arthritis
    Christian Enevold
    Institute for Inflammation Research, National University Hospital, Copenhagen, Denmark
    J Rheumatol 37:905-10. 2010
    ..Toll-like receptors (TLR) have been implicated in the pathogenesis of arthritis. We investigated the role of functional variants of TLR in the disease phenotype and severity of rheumatoid arthritis (RA)...
  18. pmc A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in Toll/IL-1R-induced inflammatory signaling
    Navin Rao
    Johnson and Johnson Pharmaceutical Research and Development, 3210 Merryfield Row, San Diego, CA 92121, USA
    Mol Cell Biol 25:6521-32. 2005
    ....
  19. ncbi TLR8 and TLR7 are involved in the host's immune response to human parechovirus 1
    Kathy Triantafilou
    University of Sussex, Infection and Immunity Group, School of Life Sciences, Brighton, UK
    Eur J Immunol 35:2416-23. 2005
    ..In this study we show that mainly TLR8 and also TLR7 act as the host sensors for human parechovirus 1, a single-stranded RNA (ssRNA) virus...
  20. doi TLR activation pathways in HIV-1-exposed seronegative individuals
    Mara Biasin
    Cattedra di Immunologia, Universita degli Studi di Milano, Milan, Italy
    J Immunol 184:2710-7. 2010
    ..from heterosexually ESN individuals were stimulated with agonists specific for TLR3 (poly I:C), TLR4 (LPS), TLR7 (imiquimod), and TLR7/8 (ssRNA40)...
  21. ncbi Cloning and characterization of a sub-family of human toll-like receptors: hTLR7, hTLR8 and hTLR9
    T H Chuang
    Department of Immunology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037 USA
    Eur Cytokine Netw 11:372-8. 2000
    ..Human TLR7-9, like the previously described members hTLR1-6 contain an ectodomain with multiple leucine-rich repeats (LRRs) ..
  22. ncbi Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848
    Marion Jurk
    Nat Immunol 3:499. 2002
  23. pmc Interferon-alpha and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets
    Tomoki Ito
    First Department of Internal Medicine, Kansai Medical University, 10 15 Fumizono cho, Moriguchi City, Osaka 570 8506, Japan
    J Exp Med 195:1507-12. 2002
    ..This study demonstrates that TLR-7 exerts its biological effect in a DC subset-specific manner...
  24. ncbi The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling
    Annett Schoenemeyer
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 280:17005-12. 2005
    ..we show that in contrast to IRF3 and IRF7, IRF5 is not a target of the TLR3 signaling pathway but is activated by TLR7 or TLR8 signaling...
  25. ncbi Plasmacytoid dendritic cells control TLR7 sensitivity of naive B cells via type I IFN
    Isabelle Béatrice Bekeredjian-Ding
    Department of Internal Medicine, Division of Clinical Pharmacology, University of Munich, Munich, Germany
    J Immunol 174:4043-50. 2005
    ..In this study we identified a fundamental difference in the regulation of TLR7- and TLR9-mediated B cell stimulation: whereas the induction of polyclonal naive B cell proliferation by the TLR7 ..
  26. ncbi Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA
    Katalin Kariko
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Immunity 23:165-75. 2005
    ..We show that RNA signals through human TLR3, TLR7, and TLR8, but incorporation of modified nucleosides m5C, m6A, m5U, s2U, or pseudouridine ablates activity...
  27. ncbi Isatoribine, an agonist of TLR7, reduces plasma virus concentration in chronic hepatitis C infection
    Yves Horsmans
    Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Unit de Pharmacologie Clinique, Brussels, Belgium
    Hepatology 42:724-31. 2005
    ..Isatoribine is a selective agonist of TLR7. In a proof-of-concept study, we found that once-daily 7-day treatment with intravenous isatoribine 800 mg caused a ..
  28. ncbi Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses
    Kun Yang
    Laboratory of Human Genetics of Infectious Diseases, University of Paris René Descartes INSERM U550, Necker Medical School, 75015 Paris, France
    Immunity 23:465-78. 2005
    ..The TLR-7-, TLR-8-, and TLR-9-dependent induction of IFN-alpha/beta and -lambda is strictly IRAK-4 dependent and paradoxically redundant for protective immunity to most viruses in humans...
  29. ncbi Toll-like receptor 7-dependent loss of B cell tolerance in pathogenic autoantibody knockin mice
    Robert Berland
    Department of Pathology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Immunity 25:429-40. 2006
    ..This autoantibody production was largely dependent on Toll-like receptor 7 (TLR7). We further show that production of these autoantibodies was sufficient to cause kidney pathology in these mice...
  30. ncbi Polymorphisms in Toll-like receptor 9 influence the clinical course of HIV-1 infection
    Pierre Yves Bochud
    Institute for Systems Biology, Seattle, Washington State, USA
    AIDS 21:441-6. 2007
    ..Toll-like receptors (TLRs) have a key role in innate immunity and mutations in the genes encoding these receptors have been associated with increased or decreased susceptibility to infections...
  31. ncbi A Toll-like receptor 7 single nucleotide polymorphism protects from advanced inflammation and fibrosis in male patients with chronic HCV-infection
    Eckart Schott
    Department of Hepatology and Gastroenterology, CVK, Charite Universitatsmedizin Berlin, Germany
    J Hepatol 47:203-11. 2007
    ..Since HCV is an RNA virus, a role for TLR7 in the immune response against HCV is likely...
  32. pmc Manipulation of the toll-like receptor 7 signaling pathway by Epstein-Barr virus
    Heather J Martin
    Johns Hopkins School of Medicine, Bunting Blaustein Building CRB308, 1650 Orleans Street, Baltimore, MD 21231 1000, USA
    J Virol 81:9748-58. 2007
    ..Both UV-inactivated and untreated EBV upregulated the expression of TLR7 and downregulated the expression of TLR9 in naive B cells...
  33. pmc HIV turns plasmacytoid dendritic cells (pDC) into TRAIL-expressing killer pDC and down-regulates HIV coreceptors by Toll-like receptor 7-induced IFN-alpha
    Andrew W Hardy
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:17453-8. 2007
    ..We also show that HIV-1-induced IKpDC depended on Toll-like receptor 7 (TLR7) activation...
  34. ncbi Genetic polymorphisms of viral infection-associated Toll-like receptors in Chinese population
    Pei Lin Cheng
    Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Transl Res 150:311-8. 2007
    ..for the single nucleotide polymorphisms (SNPs) in TLRs associated with viral infection, including TLR2, TLR3, TLR4, TLR7, TLR8, and TLR9...
  35. ncbi Association of TLR7 single nucleotide polymorphisms with chronic HCV-infection and response to interferon-a-based therapy
    E Schott
    Department of Hepatology and Gastroenterology, CVK, Charite Universitatsmedizin, Berlin, Germany
    J Viral Hepat 15:71-8. 2008
    ..As HCV is a single-stranded RNA virus, a role for TLR7 in the immune response against HCV is possible, and early clinical studies have demonstrated an antiviral effect of ..
  36. doi Recognition of nucleic acid and nucleic acid analogs by Toll-like receptors 7, 8 and 9
    Stefan Bauer
    Institut fur Immunology, Philipps Universitat Marburg, BMFZ, Hans Meerweinstr 2, 35043 Marburg, Germany
    Immunobiology 213:315-28. 2008
    ..b>TLR7-9 recognize single-stranded RNA, nucleoside analogs and single-stranded CpG-DNA, respectively, and their activation ..
  37. doi Association analysis identifies TLR7 and TLR8 as novel risk genes in asthma and related disorders
    S Møller-Larsen
    Institute of Human Genetics, The Bartholin Building, University of Aarhus, 8000 Aarhus C, Denmark
    Thorax 63:1064-9. 2008
    ..By genome scanning, evidence of linkage between chromosome Xp22 and asthma and related atopic disorders has previously been obtained. Xp22 harbours the TLR7 and TLR8 genes.
  38. doi Role of atopic status in Toll-like receptor (TLR)7- and TLR9-mediated activation of human eosinophils
    Anne Mansson
    Laboratory of Clinical and Experimental Allergy Research, Department of Otorhinolaryngology, Malmo University Hospital, Lund University, Malmo, Sweden
    J Leukoc Biol 85:719-27. 2009
    ..Herein, we investigated the expression and function of TLR7 and TLR9 in purified eosinophils from peripheral blood and assessed their role in allergic airway inflammation...
  39. pmc TLR7 stimulation in human plasmacytoid dendritic cells leads to the induction of early IFN-inducible genes in the absence of type I IFN
    Jérémy Di Domizio
    Universite Joseph Fourier, Grenoble, France
    Blood 114:1794-802. 2009
    On recognition of influenza virus (Flu) by TLR7, plasmacytoid dendritic cells (pDCs) produce type I IFN in significant amounts...
  40. doi Impaired expression and function of toll-like receptor 7 in hepatitis C virus infection in human hepatoma cells
    Serena Chang
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
    Hepatology 51:35-42. 2010
    ..We hypothesize that HCV infection may interfere with the expression and/or function of TLR7, a sensor of single-stranded RNA...
  41. doi Expression of Toll-like receptors 7, 8, and 9 in primary Sjögren's syndrome
    Lingyan Zheng
    Department of Oral and Maxillofacial Surgery, Ninth People s Hospital, School of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, Shanghai, China
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109:844-50. 2010
    ..was to investigate the level of Toll-like receptors (TLRs) 7, 8, and 9 in peripheral mononuclear blood cells (PMBCs) from patients with primary Sjögren's syndrome (pSS) and whether TLR7 and 9 exist in the parotid glands of pSS patients.
  42. pmc TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus
    Cristiana Guiducci
    Dynavax Technologies Corporation, 2929 Seventh Street, Suite 100, Berkeley, California 94710, USA
    Nature 465:937-41. 2010
    ..Recognition of self nucleic acids by toll-like receptors TLR7 and TLR9 on B cells and plasmacytoid dendritic cells (PDCs) is an important step in the pathogenesis of SLE, ..
  43. pmc Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus
    Nan Shen
    Shanghai Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
    Proc Natl Acad Sci U S A 107:15838-43. 2010
    ..Previous findings that duplicated Toll-like receptor 7 (Tlr7) promotes lupus-like disease in male BXSB mice prompted us to evaluate TLR7 in human SLE...
  44. doi Toll-like receptor 7 rs179008/Gln11Leu gene variants in chronic hepatitis C virus infection
    Eva Askar
    Department of Gastroenterology and Endocrinology, University Medical Center, Georg August University, Goettingen, Germany
    J Med Virol 82:1859-68. 2010
    ..Sensing of viral single-stranded RNA (ssRNA) by Toll-like receptor 7 (TLR7) is likely involved in early pathogen detection and host response to viral infections...
  45. pmc TLR7 single-nucleotide polymorphisms in the 3' untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association study
    Aya Kawasaki
    Molecular and Genetic Epidemiology Laboratory, Doctoral Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba 305 8575, Japan
    Arthritis Res Ther 13:R41. 2011
    The Toll-like receptor 7 (TLR7) gene, encoded on human chromosome Xp22.3, is crucial for type I interferon production...
  46. pmc Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c⁺ B-cell population is important for the development of autoimmunity
    Anatoly V Rubtsov
    Howard Hughes Medical Institute and Department of Immunology, National Jewish Health and University of Colorado Health Sciences Center, Denver, CO 80206, USA
    Blood 118:1305-15. 2011
    ..We were able to detect a similar population of B cells in the peripheral blood of some elderly women with autoimmune disease, suggesting that there may be parallels between the creation of ABC-like cells between mice and humans...
  47. pmc TLR7 and TLR8 gene variations and susceptibility to hepatitis C virus infection
    Chiou Huey Wang
    Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    PLoS ONE 6:e26235. 2011
    ..We previously evaluated associations between TLR7 and TLR8 gene SNPs and susceptibility to hepatitis C virus (HCV) infection...
  48. doi TLR7/8/9 polymorphisms and their associations in systemic lupus erythematosus patients from southern Brazil
    B P dos Santos
    Laboratory of Immunogenetics, Department of Genetics, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Lupus 21:302-9. 2012
    ..It is characterized by high production of autoantibodies against nuclear compounds. TLR7/8/9 are responsible for nucleic acid recognition and they trigger proinflammatory responses through activation of ..
  49. doi An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration
    Sabrina M Lehmann
    Department of Neurology, Charite Universitaetsmedizin Berlin, Berlin, Germany
    Nat Neurosci 15:827-35. 2012
    ..let-7 activates the RNA-sensing Toll-like receptor (TLR) 7 and induces neurodegeneration through neuronal TLR7. Cerebrospinal fluid (CSF) from individuals with Alzheimer’s disease contains increased amounts of let-7b, and ..
  50. pmc B cell TLR7 expression drives anti-RNA autoantibody production and exacerbates disease in systemic lupus erythematosus-prone mice
    Sun Hee Hwang
    Department of Immunology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    J Immunol 189:5786-96. 2012
    ..Recent data have highlighted an important role for the TLR family, particularly TLR7, in both human disease and murine models...
  51. pmc MicroRNA-3148 modulates allelic expression of toll-like receptor 7 variant associated with systemic lupus erythematosus
    Yun Deng
    Division of Rheumatology, University of California Los Angeles, Los Angeles, California, USA
    PLoS Genet 9:e1003336. 2013
    We previously reported that the G allele of rs3853839 at 3'untranslated region (UTR) of Toll-like receptor 7 (TLR7) was associated with elevated transcript expression and increased risk for systemic lupus erythematosus (SLE) in 9,274 ..
  52. doi Differential TLR7-mediated expression of proinflammatory and antiviral cytokines in response to laboratory and clinical enterovirus strains
    Wassim Chehadeh
    Virology Unit, Department of Microbiology, Faculty of Medicine, Kuwait University, Safat 13310, Kuwait
    Virus Res 174:88-94. 2013
    ..Toll-like receptor 7 (TLR7) mediates the activation of type I interferon genes and the development of inflammatory cytokine response...
  53. doi Distinct autoantibody profiles in systemic lupus erythematosus patients are selectively associated with TLR7 and TLR9 upregulation
    Sudhir Kumar Chauhan
    Department of Molecular and Human Genetics, Banaras Hindu University, Varanasi 221005, India
    J Clin Immunol 33:954-64. 2013
    ..We took up this study to identify if unique TLR expression patterns are associated with distinct autoantibody profiles in SLE...
  54. pmc A modified dinucleotide motif specifies tRNA recognition by TLR7
    Steffen Kaiser
    Institute of Pharmacy and Biochemistry, Johannes Gutenberg University Mainz, 55128 Mainz, Germany
    RNA 20:1351-5. 2014
    ..The recognition of tRNA as either self or nonself RNA by TLR7 depends on its modification patterns...
  55. ncbi Sensitization of IL-2 signaling through TLR-7 enhances B lymphoma cell immunogenicity
    Jelena Tomic
    Division of Molecular and Cellular Biology, Research Institute, Sunnybrook and Women s College Health Sciences Center, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    J Immunol 176:3830-9. 2006
    ..These findings suggest that TLR-7 "licenses" human B cells to respond to cytokines of the adaptive immune system (such as IL-2) and provide a strategy to increase the immunogenicity of lymphoma cells for therapeutic purposes...
  56. ncbi Variation in the relative copy number of the TLR7 gene in patients with systemic lupus erythematosus and healthy control subjects
    James Kelley
    The University of Alabama at Birmingham, AL 35294, USA
    Arthritis Rheum 56:3375-8. 2007
    To determine whether there is an increase in the number of TLR7 gene copies in patients diagnosed as having systemic lupus erythematosus (SLE) and whether gene amplification influences the autoantibody profiles in SLE patients, as has ..
  57. ncbi Investigation of TLR5 and TLR7 as candidate genes for susceptibility to systemic lupus erythematosus
    E Sanchez
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Clin Exp Rheumatol 27:267-71. 2009
    The aim of this study was to evaluate the relevance of genetic variants of TLR5 (rs5744168) and TLR7 (rs179008) gene in systemic lupus erythematosus (SLE) in a Spanish population.
  58. doi Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9
    Ning Yu
    Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, PR China
    J Dermatol Sci 56:113-20. 2009
    ..However, the mechanisms of recognition of microbes by melanocytes have not yet been fully established...
  59. pmc The heterogeneous allelic repertoire of human toll-like receptor (TLR) genes
    Philippe Georgel
    Laboratoire d Immunogénétique Moléculaire Humaine, Centre de Recherche d Immunologie et d Hématologie, Faculte de Medecine, Universite de Strasbourg, Strasbourg, France
    PLoS ONE 4:e7803. 2009
    ..Hence this work depicts a first overview of the diversity of almost all human TLR genes, a prelude for large-scale population genetics as well as genetic association studies...
  60. doi Increased expression of TLR7 in CD8(+) T cells leads to TLR7-mediated activation and accessory cell-dependent IFN-gamma production in HIV type 1 infection
    Yang Song
    Department of Infectious Diseases, Tangdu Hospital Affiliated to the Fourth Military Medical University, Xi an 710038, PR China
    AIDS Res Hum Retroviruses 25:1287-95. 2009
    ..In this study, we analyzed expression of TLR4, TLR5, TLR7, and TLR8 in CD8(+) T cells in HIV-1 infection...
  61. ncbi Three novel mammalian toll-like receptors: gene structure, expression, and evolution
    X Du
    Scripps Research Institute, 10550 N Torrey Pines Road, IMM 31, R204, La Jolla, CA 92037, USA
    Eur Cytokine Netw 11:362-71. 2000
    We describe three novel genes, encoding members of the Toll-like receptor (Tlr) family (TLR7, TLR8, and TLR9). These Tlr family members, unlike others reported to date, were identified within a genomic database...
  62. ncbi Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling
    Christian Kollewe
    Department of Pharmacology, Hannover Medical School, D 30623 Hannover, Germany
    J Biol Chem 279:5227-36. 2004
    ..Thus, IRAK-1 regulates its own availability as an adapter molecule by sequential autophosphorylation...
  63. doi Identification, characterization and genetic mapping of TLR7, TLR8a1 and TLR8a2 genes in rainbow trout (Oncorhynchus mykiss)
    Yniv Palti
    United States Department of Agriculture, Agriculture Research Service, National Center for Cool and Cold Water Aquaculture, Kearneysville, WV 25430, USA
    Dev Comp Immunol 34:219-33. 2010
    ..Herein, we identify and describe the rainbow trout (Oncorhynchus mykiss) TLR7 and TLR8 gene orthologs and their mRNA expression...
  64. pmc TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA
    Hiroyasu Konno
    Division of Cellular and Molecular Biology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    PLoS ONE 4:e5674. 2009
    ..Toll-like receptor 7 (TLR7) and TLR9 detect viral RNA and DNA, respectively, in endosomal compartments, leading to the activation of nuclear ..
  65. ncbi Sensitivity of TLR4- and -7-induced NF kappa B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages
    Katie J Loniewski
    Division of Pathology, Department of Physiology, Michigan State University, East Lansing, MI 48824, USA
    Mol Immunol 44:3715-23. 2007
    ..Recent studies using macrophages from TRAF6 knockout mice have revealed that TRAF6 is required for TLR7 signaling. However, an essential role of TRAF6 in TLR4 signaling and cytokine production is slightly controversial...
  66. ncbi U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells through TLR7
    Emina Savarese
    Department of Internal Medicine, Technical University Munich, Germany
    Blood 107:3229-34. 2006
    ..by U1snRNPs in murine bone marrow-derived PDCs required the presence of intact U1RNA and was largely dependent on Tlr7 but independent of Tlr3...
  67. doi Type I interferons might form the link between Toll-like receptor (TLR) 3/7 and TLR4-mediated synovial inflammation in rheumatoid arthritis (RA)
    M F Roelofs
    Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen 6500 HB, The Netherlands
    Ann Rheum Dis 68:1486-93. 2009
    ..Toll-like receptors (TLR) probably play a role in synovial inflammation and may also contribute to the understanding of the role of infections in RA...
  68. pmc TLR7-dependent and FcgammaR-independent production of type I interferon in experimental mouse lupus
    Pui Y Lee
    Division of Rheumatology and Clinical Immunology and Center for Autoimmune Disease, University of Florida, Gainesville, FL 32610, USA
    J Exp Med 205:2995-3006. 2008
    ..In vitro studies revealed that TMPD augments the effect of TLR7 ligands but does not directly activate TLR7 itself...
  69. pmc First-line therapy for human cutaneous leishmaniasis in Peru using the TLR7 agonist imiquimod in combination with pentavalent antimony
    Cesar Miranda-Verastegui
    Universidad Peruana Cayetano Heredia, Lima, Peru
    PLoS Negl Trop Dis 3:e491. 2009
    ..We evaluated if pentavalent antimony (an anti-parasitic drug) combined with imiquimod (an immunomodulator) was more effective than pentavalent antimony alone in patients who had not previously been treated...
  70. doi miR-155 and its star-form partner miR-155* cooperatively regulate type I interferon production by human plasmacytoid dendritic cells
    Haibo Zhou
    Joint Molecular Rheumatology Laboratory of the Institute of Health Sciences and Shanghai Renji Hospital, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Shanghai Jiaotong University School of Medicine, Shanghai, China
    Blood 116:5885-94. 2010
    ..miRNA profiling showed the significantly differential expression of 19 miRNAs in PDCs after Toll-like receptor 7 (TLR7) stimulation, among which miR-155* and miR-155 were the most highly induced...
  71. pmc Enhanced immunogenicity of Plasmodium falciparum peptide vaccines using a topical adjuvant containing a potent synthetic Toll-like receptor 7 agonist, imiquimod
    Caroline Othoro
    Department of Medical Parasitology, New York University Cancer Institute, School of Medicine, New York University, New York, New York 10010, USA
    Infect Immun 77:739-48. 2009
    ..A synthetic TLR7 agonist, imiquimod, which is FDA approved for topical treatment of various skin conditions, can function as a ..
  72. pmc TLR-mediated up-regulation of serum retroviral gp70 is controlled by the Sgp loci of lupus-prone mice
    Lucie Baudino
    Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland
    J Autoimmun 35:153-9. 2010
    ..Given critical roles of TLR7 and TLR9 in the pathogenesis of SLE, we assessed their contribution to the acute phase expression of serum gp70, ..
  73. pmc Transcriptional networks in plasmacytoid dendritic cells stimulated with synthetic TLR 7 agonists
    Woubalem Birmachu
    Pharmacology, 3M Pharmaceuticals, St Paul, Minnesota, USA
    BMC Immunol 8:26. 2007
    ..To this end, we evaluated changes in global gene expression upon stimulation of 99.9% pure human pDC with the TLR7 selective agonists 3M-852A, and the TLR7/8 agonist 3M-011.
  74. ncbi Immunoadjuvant effects of polyadenylic:polyuridylic acids through TLR3 and TLR7
    Takahiro Sugiyama
    Laboratory for Host Defense, RIKEN Research Center for Allergy and Immunology, Suehiro cho 1 7 22, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Int Immunol 20:1-9. 2008
    ..Poly(A:U)-induced IFN-alpha production depended on a DC subset, plasmacytoid dendritic cell (pDC), and required TLR7. IL-12p40 was also produced by poly(A:U)-stimulated pDC in a TLR7-dependent manner...
  75. doi Toll-like receptor 7 function is reduced in adolescents with asthma
    M Roponen
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Australia
    Eur Respir J 35:64-71. 2010
    ..The aim of the present study was to investigate TLR7 and TLR3 function in 14-yr-old adolescents with asthma...
  76. ncbi TLR7 imidazoquinoline ligand 3M-019 is a potent adjuvant for pure protein prototype vaccines
    Dean Johnston
    Hunter College School of Health Sciences, New York, NY, USA
    Cancer Immunol Immunother 56:1133-41. 2007
    ..b>TLR7 ligands produce strong cellular responses and specific IgG2a and IgG2b antibody responses to protein immunogens...
  77. ncbi Engagement of TLR3, TLR7, and NKG2D regulate IFN-gamma secretion but not NKG2D-mediated cytotoxicity by human NK cells stimulated with suboptimal doses of IL-12
    María V Girart
    Laboratorio de Inmunogenética, Hospital de Clinicas Jose de San Martin, Buenos Aires, Argentina
    J Immunol 179:3472-9. 2007
    NK cells express different TLRs, such as TLR3, TLR7, and TLR9, but little is known about their role in NK cell stimulation...
  78. doi TLR7 and TLR8 ligands and antiphospholipid antibodies show synergistic effects on the induction of IL-1beta and caspase-1 in monocytes and dendritic cells
    Julia Hurst
    Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg University, Lagenbeckstr 1, 55131 Mainz, Germany
    Immunobiology 214:683-91. 2009
    ..We investigated the induction of IL-1beta production in monocytes and pDCs stimulated with ligands for TLR7 and TLR8 and with antiphospholipid antibodies (aPL)...
  79. pmc Increased susceptibility for superinfection with Streptococcus pneumoniae during influenza virus infection is not caused by TLR7-mediated lymphopenia
    Sabine Stegemann
    Otto von Guericke University, Institute of Molecular and Clinical Immunology, Magdeburg, Germany
    PLoS ONE 4:e4840. 2009
    ..We previously demonstrated that triggering of TLR7 causes immune incompetence in mice by induction of lymphopenia...
  80. pmc Lactate dehydrogenase-elevating virus induces systemic lymphocyte activation via TLR7-dependent IFNalpha responses by plasmacytoid dendritic cells
    Christoph G Ammann
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA
    PLoS ONE 4:e6105. 2009
    ..The mechanism of this activation has not been fully described and is the focus of the current studies...
  81. pmc Stimulation of human dendritic cells by wild-type and M protein mutant vesicular stomatitis viruses engineered to express bacterial flagellin
    Maryam Ahmed
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Virol 84:12093-8. 2010
    ..as recombinant wild-type (rwt) virus, stimulate maturation of dendritic cells (DC) through Toll-like receptor 7 (TLR7) and its adaptor molecule MyD88...
  82. ncbi Identification of signaling pathways in macrophage exposed to Porphyromonas gingivalis or to its purified cell wall components
    Qingde Zhou
    Department of Periodontology and Oral Biology, School of Dental Medicine, Boston University, Boston, MA 02118, USA
    J Immunol 179:7777-90. 2007
    ..Using gene knockout mice and siRNA to silence mouse genes, we showed that both TLR2 and TLR7 are essential for the induction of NFkappaB-containing genes and NFkappaB-IFN-sensitive response element (ISRE) ..
  83. ncbi TLR7/9 antagonists as therapeutics for immune-mediated inflammatory disorders
    Siquan Sun
    Department of Immunology, Johnson and Johnson Pharmaceutical Research and Development, L L C, 3210 Merryfield Row, San Diego, CA 92121, USA
    Inflamm Allergy Drug Targets 6:223-35. 2007
    There is an increasing interest in ligands of nucleic acid-sensing Toll-like receptors (TLR), especially TLR7 and TLR9, for pharmacological intervention in various diseases...
  84. pmc Toll-like receptor 7 and 9 defects in common variable immunodeficiency
    Joyce E Yu
    Department of Medicine, Mount Sinai Medical Center, New York, NY 10029, USA
    J Allergy Clin Immunol 124:349-56, 356.e1-3. 2009
    ..Common variable immunodeficiency (CVID) is characterized by hypogammaglobulinemia, reduced numbers of peripheral blood isotype-switched memory B cells, and loss of plasma cells...
  85. pmc Nanoparticle-delivered multimeric soluble CD40L DNA combined with Toll-Like Receptor agonists as a treatment for melanoma
    Geoffrey W Stone
    Department of Medicine, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 4:e7334. 2009
    ..TLR2/6 (FSL-1 and MALP2), TLR3 (polyinosinic-polycytidylic acid, poly(I:C)), TLR4 ( monophosphoryl lipid A, MPL), TLR7 (imiquimod), or TLR9 (Class B CpG phosphorothioate oligodeoxynucleotide, CpG)...
  86. pmc Phosphorothioate 2' deoxyribose oligomers as microbicides that inhibit human immunodeficiency virus type 1 (HIV-1) infection and block Toll-like receptor 7 (TLR7) and TLR9 triggering by HIV-1
    Joseph A Fraietta
    Department of Microbiology and Immunology, Center for Immunology and Vaccine Science, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    Antimicrob Agents Chemother 54:4064-73. 2010
    ..Phosphorothioate 2' deoxyribose oligomers may therefore be promising microbicide candidates that inhibit HIV-1 infection and also dampen the inflammation which is critical for the initial spread of the virus...
  87. doi Effect of TLR3 and TLR7 activation in uterine NK cells from non-obese diabetic (NOD) mice
    Yi Lin
    Institute of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiaotong University, PR China
    J Reprod Immunol 82:12-23. 2009
    ..Herein, we investigated the effect of specific TLR3 and TLR7 agonists, poly (I:C) and R837, individually and in combination, on uterine immune cell function and their ..
  88. pmc Investigating Toll-like receptor agonists for potential to treat hepatitis C virus infection
    Amy Thomas
    Discovery Biology IPC424, Pfizer Global Research and Development, Sandwich, Kent, UK
    Antimicrob Agents Chemother 51:2969-78. 2007
    ..Recently, agonists of TLR7 and TLR9 have been shown to have clinical efficacy in HCV patients, and this is correlated with their ability to ..
  89. ncbi Expression and function of Toll-like receptors in eosinophils: activation by Toll-like receptor 7 ligand
    Hiroyuki Nagase
    Department of Respiratory Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    J Immunol 171:3977-82. 2003
    ..Eosinophils constitutively expressed TLR1, TLR4, TLR7, TLR9, and TLR10 mRNAs (TLR4 greater than TLR1, TLR7, TLR9, and TLR10 greater than TLR6)...
  90. ncbi TLR3-, TLR7-, and TLR9-mediated production of proinflammatory cytokines and chemokines from murine connective tissue type skin-derived mast cells but not from bone marrow-derived mast cells
    Hironori Matsushima
    Department of Dermatology, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Tamaho, Nakakoma, Yamanashi 409 3898, Japan
    J Immunol 173:531-41. 2004
    ..Although TLR2 and TLR4 mRNA were detected in both cells at comparable levels, TLR3, TLR7, and TLR9 mRNA were expressed by FSMC at higher levels than by BMMC, suggesting distinct TLR expression profiles ..
  91. ncbi Human Toll-like receptor-dependent induction of interferons in protective immunity to viruses
    Shen Ying Zhang
    Laboratory of Human Genetics of Infectious Diseases, Institut National de la Sante et de la Recherche Medicale, Paris, France, EU
    Immunol Rev 220:225-36. 2007
    Five of the 10 human Toll-like receptors (TLRs) (TLR3, TLR4, TLR7, TLR8, and TLR9), and four of the 12 mouse TLRs (TLR3, TLR4, TLR7, TLR9) can trigger interferon (IFN)-alpha, IFN-beta, and IFN-lambda, which are critical for antiviral ..
  92. pmc Vesicular stomatitis virus M protein mutant stimulates maturation of Toll-like receptor 7 (TLR7)-positive dendritic cells through TLR-dependent and -independent mechanisms
    Maryam Ahmed
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Virol 83:2962-75. 2009
    ..vesicular stomatitis virus (VSV) strains stimulate plasmacytoid dendritic cells (pDC) through Toll-like receptor 7 (TLR7) and its adaptor molecule, MyD88...
  93. ncbi The small antitumoral immune response modifier imiquimod interacts with adenosine receptor signaling in a TLR7- and TLR8-independent fashion
    Michael P Schön
    Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine and Department of Dermatology, Bayerische Julius Maximilians University, Wurzburg, Germany
    J Invest Dermatol 126:1338-47. 2006
    ..of the transcription factor NF-kappaB and the downstream production of proinflammatory cytokines in the absence of TLR7 and TLR8...
  94. ncbi Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines
    Akiko Uehara
    Department of Microbiology and Immunology, Tohoku University Graduate School of Dentistry, 4 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Mol Immunol 44:3100-11. 2007
    ..In this study, we found clear expressions of Toll-like receptor (TLR)2, TLR3, TLR4, TLR7, NOD1 and NOD2 in oral, tongue, salivary gland, pharyngeal, esophageal, intestinal, cervical, breast, lung, and ..
  95. ncbi TLR3 and TLR7 are involved in expression of IL-23 subunits while TLR3 but not TLR7 is involved in expression of IFN-beta by Theiler's virus-infected RAW264.7 cells
    Fahd Al-Salleeh
    Department of Oral Biology, University of Nebraska Medical Center, 40th and Holdrege Streets, Lincoln, NE 68583 0740, USA
    Microbes Infect 9:1384-92. 2007
    ..Because TMEV may induce macrophages' cytokines through TLR3 and TLR7 (toll-like receptors), their role in TMEV-induced IL-23 and IFN-beta expression by the RAW264...
  96. ncbi Evidence for genes in addition to Tlr7 in the Yaa translocation linked with acceleration of systemic lupus erythematosus
    Marie Laure Santiago-Raber
    Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland
    J Immunol 181:1556-62. 2008
    ..was identified to be a translocation from the telomeric end of the X chromosome (containing the gene encoding TLR7) onto the Y chromosome...
  97. pmc Nuclear factor kappaB (NF-kappaB) activation primes cells to a pro-inflammatory polarized response to a Toll-like receptor 7 (TLR7) agonist
    Jongdae Lee
    Department of Medicine, University of California San Diego, La Jolla, CA 92093 0663, USA
    Biochem J 421:301-10. 2009
    b>TLR7 (Toll-like receptor 7) mediates anti-viral immunity by recognizing ssRNA (single-stranded RNA) viruses. Small-molecular-mass TLR7 agonists have been approved, or are being evaluated, for treatment of cancers or infectious diseases...
  98. pmc Toll-like receptor 7-induced immune response to cutaneous West Nile virus infection
    Thomas Welte
    Departments of Microbiology and Immunology, and Pathology, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    J Gen Virol 90:2660-8. 2009
    ..Here, we investigated the role of the TLR7-induced immune response following cutaneous WNV infection...
  99. doi Signaling through TLR7 enhances the immunosuppressive activity of murine CD4+CD25+ T regulatory cells
    Nicholas A Forward
    Department of Microbiology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Leukoc Biol 87:117-25. 2010
    Although signaling through certain TLRs is known to modulate the function of T lymphocytes, the effect of TLR7 stimulation on CD4(+)CD25(+) T(reg) cell activity has not yet been elucidated...
  100. pmc Short-term cultured, interleukin-15 differentiated dendritic cells have potent immunostimulatory properties
    Sébastien Anguille
    University of Antwerp Faculty of Medicine, Vaccine and Infectious Disease Institute VAXINFECTIO, Laboratory of Experimental Hematology, Universiteitsplein 1, B 2610 Wilrijk Antwerp, Belgium
    J Transl Med 7:109. 2009
    ..The applicability of these so-called IL-15 DCs has not yet been firmly established. We therefore developed a novel pre-clinical approach for the generation of IL-15 DCs with potent immunostimulatory properties...
  101. doi SNP discovery and development of genetic markers for mapping innate immune response genes in common carp (Cyprinus carpio)
    Pawapol Kongchum
    Department of Fisheries and Wildlife Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Fish Shellfish Immunol 29:356-61. 2010
    ..carp, we have amplified and sequenced 11 candidate genes for viral disease resistance including TLR2, TLR3, TLR4ba, TLR7, TLR9, TLR21, TLR22, MyD88, TRAF6, type I IFN and IL-1beta...

Research Grants64

  1. miR-155 regulation of cellular susceptibility to HIV-1 infection
    JULIO MARTIN-GARCIA; Fiscal Year: 2013
    ..We have found that stimulation of human monocyte-derived macrophages (MDMs) through TLR3 and 4, but not through TLR7 and 9, abrogates their susceptibility to HIV-1 infection...
  2. Akiko Iwasaki; Fiscal Year: 2015
    ..In previous studies we demonstrated the requirement of TLR9 and TLR7 in the activation and IFN1 secretion in response to double stranded (ds) DNA viruses, herpes simplex viruses (HSV), ..
  3. STUART MICHAEL LEVITZ; Fiscal Year: 2016
    ..cryptococcal antigens will be combined with ligands for the pathogen recognition receptors, dectin-1, TLR2, TLR7/8 and TLR9...
  4. Carla M Cuda; Fiscal Year: 2016
    ..The increased activation potential of CreCD11cCasp8flox/flox DCs may be controlled by toll-like receptos 7 and 9 (TLR7/9) since caspase 8-deficient DCs display a hyper- responsiveness to TLR7/9 ligation with increased DNA binding ..
  5. TLR7 mediates immune cell infiltration and homing to combat West Nile virus infec
    Fengwei Bai; Fiscal Year: 2010
    ..and mortality in humans and animals in North American, is a single-stranded RNA virus that can be recognized by Tlr7. Our preliminary studies demonstrated that Tlr7 deficient (Tlr7-/-) mice increase susceptibility to WNV infection...
  6. Yong Jun Liu; Fiscal Year: 2014
    ..IFN)-producing cells of the immune system3-8 that are specialized in recognizing viral RNA and DNA via endosomal TLR7 and TLR9, respectively...
  7. Virus interference with Toll like Receptor Response on Dendritic Cells
    Elina I Zuniga; Fiscal Year: 2010
    ..with Lymphocytic choriomeningitis virus (LCMV) differentially modulates subsequent TLR challenges inhibiting TLR3, TLR7 and TLR9 responses and enhancing TLR4 signaling (Zuniga et al. Cell Host &Microbe. 2008)...
  8. Nina Bhardwaj; Fiscal Year: 2015
    ..pDCs, but not cDCs, undergo activation following CD4 mediated endocytosis of HIV-1 and subsequent activation of TLR7 with genomic RNA...
  9. Melissa Victoria Fernandez; Fiscal Year: 2014
    ..pDCs, but not cDCs, undergo activation following CD4 mediated endocytosis of HIV-1 and subsequent activation of TLR7 with genomic RNA...
  10. Inhibitors of Toll-like receptors 7 & 9 for treatment of skin inflammation
    FRANCK BARRAT; Fiscal Year: 2010
    ..activation of both cell types appears due to stimulation by DNA and RNA acting through the innate immune receptors, TLR7 and TLR9...
  11. HEATHER WINONA STOUT-DELGADO; Fiscal Year: 2015
    ..and represent a major source of type 1 IFN post exposure to viral infections or Toll-Like Receptor 9 (TLR9) or TLR7 specific ligands...
  12. Claudia V Jakubzick; Fiscal Year: 2016
    ..Our central hypothesis is that both TLR3+CD103+ DC and TLR7+CD11bhi lung DCs, possess the capacity to promote the development of cytotoxic T cells directed to tumor-associated ..
  13. EDUARTA K HOLL; Fiscal Year: 2014
    ..For example, inhibition of TLR7 and 9 results in reduced inflammation and glomerulonephritis, a hallmark of SLE...
  14. Immunomodulation in melanoma therapy
    NOAH A CRAFT; Fiscal Year: 2012
    ..Preliminary data suggests that the TLR7 agonist, imiquimod, is an effective adjuvant to immunization with recombinant Listeria monocytogenes (rLM) ..
  15. Hidde L Ploegh; Fiscal Year: 2015
    ..These include a TLR9-GFP transgenic mouse, to be complemented by a TLR7-GFP mouse, and a transnuclear (TN) mouse model made by somatic cell nuclear transfer, using the nucleus of an ..
  16. Development of TLR8 inhibitors for treatment of autoimmune diseases
    Cristiana Guiducci; Fiscal Year: 2013
    ..significantly to sterile inflammation and autoimmunity, with the clearest example being the role played by TLR9 and TLR7 in the pathogenesis of systemic lupus erythematosus (SLE)...
  17. Defining the Pathogenesis of Immune Deficiency in Chronic HIV Infection
    MICHAEL MARCEL LEDERMAN; Fiscal Year: 2012
    ..of Montreal, will examine the role of innate immune system activation through the interaction between HIV RNAs and TLR7/8 on the expression of PDL-1 and 2 and their effects on the function and survival of HIV reactive T cells...
  18. TLR-mediated gender differences in HIV-1 pathogenesis
    Marcus Altfeld; Fiscal Year: 2013
    ..produce significantly higher amounts of pro-inflammatory cytokines than pDCs from men in response to HIV-1 encoded TLR7 ligands...
  19. T Cell Tolerance &Autoimmunity to Nuclear Antigen La
    A Darise Farris; Fiscal Year: 2012
    ..presenting cell (APC) and T cell phenotypes in mice mildly (2X) over-expressing RNA-binding Toll-like receptor 7 (TLR7) in the absence of other lupus susceptibility loci suggest that one cue could be constitutive stimulation of ..
  20. A transfollicular nanovaccine against leishmaniasis
    PAIMAN PETER GHOROGHCHIAN; Fiscal Year: 2012
    ..AIM 1 Construct a nanovaccine encapsulating the antigen LACK and TLR7/8 agonist RSQ (LACK/RSQ-NPS)...
  21. Sterile Hepatic Inflammation
    Wajahat Zafar Mehal; Fiscal Year: 2012
    ..ii) Activation of TLR7 and 9 is required for up-regulation of pro-IL-1b and pro-IL-18 transcripts in the liver and full APAP ..
  22. Akiko Iwasaki; Fiscal Year: 2014
    ..work has demonstrated that autophagy plays a key role in recognizing signatures of viral infection in pDCs through TLR7. In contrast to pDCs, most other cell types of the body utilize cytosolic sensors of viral replication via RIG-I ..
  23. Immunomodulation in melanoma: Toll like receptors and therapeutic vaccines
    NOAH A CRAFT; Fiscal Year: 2010
    ..Preliminary data suggests that the TLR7 agonist, imiquimod, is an effective adjuvant to immunization with recombinant Listeria monocytogenes (rLM) ..
  24. Identification of agents that induce E-selectin on human endothelial cells
    RACHAEL ANN CLARK; Fiscal Year: 2012
    ..Treatment of SCC with the TLR7 agonist imiquimod induces vascular E-selectin, influx of skin homing effector T cells and immunologic destruction ..
  25. Eric G Pamer; Fiscal Year: 2016
    ..difficile infection in antibiotic treated mice and demonstrated that stimulating TLR-5 with bacterial flagellin or TLR7/8 with resiquimod markedly enhances resistance to C. difficile infection...
  26. Robert E Lanford; Fiscal Year: 2014
    ..In aim 3, we will knockdown TLR7, the primary receptor on plasmacytoid dendritic cells sensing viral RNA and triggering IFN production...
  27. Immune Evasion in Human Squamous Cell Carcinomas of the Skin
    RACHAEL ANN CLARK; Fiscal Year: 2013
    ..Imiquimod, a TLR7 agonist effective in the treatment of skin cancers, neutralizes both of these defenses, inducing expression of E-..
  28. Qing Yi; Fiscal Year: 2016
    ..role at the interface of innate and acquired immunity in anti-viral responses by sensing viral infection through TLR7/TLR9 and rapidly producing large amounts of type 1 interferons (IFNs)...
  29. Clustered receptor-signaling domains as novel HIV vaccine genetic adjuvants
    GEOFFREY WILLIAM STONE; Fiscal Year: 2012
    ..Other models have shown protection from tumor challenge with mixtures of TLR7 agonists and CD40 stimulation...
  30. Kun Ping Lu; Fiscal Year: 2015
    ..Recently, Hypothesizing a role for Pin1 in TLR signaling, we have shown that TLR7/9 ligation activates Pin1, which then activates IRAK1 in TLR7/9 signaling and type I IFN-mediated innate and ..
  31. Mahyar Nouri-Shirazi; Fiscal Year: 2014
    ..data revealed that among TLR agonists tested, nicotine has limited adverse effect on DC and NK cells responses to a TLR7/8 agonist (Fig. 2)...
  32. NLR control of antiviral defense in the respiratory mucosa
    Akiko Iwasaki; Fiscal Year: 2010
    ..Influenza virus infection is known to be recognized by two innate sensors, the Toll like receptor 7 (TLR7) and cytosolic RNA sensor RIG-I...
  33. Screening for Inhibitors of TLR8 for Treatment of Rheumatoid Arthritis
    Robert L Coffman; Fiscal Year: 2013
    ..significantly t sterile inflammation and autoimmunity, with the clearest example being the role played by TLR9 and TLR7 in the pathogenesis of systemic lupus erythematosus (SLE)...
  34. Ramon G B Bonegio; Fiscal Year: 2016
    ..In preliminary studies using this model, we discovered an important role of Toll-like receptor 7 (TLR7), a receptor activated by single stranded RNA, in the pathogenesis of immune complex glomerulonephritis...
  35. T-follicular helper cells in Env-immunized macaques
    CHARLES DAVID PAUZA; Fiscal Year: 2013
    ..of Env (changing protein or glycan structures), incorporation of cytokines, or vaccine formulations which add TLR7/8 agonists, all strategies to improve the Tfh response and memory B cell formation...
  36. Westley H Reeves; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Dysregulated production of Type I interferon (IFN-I) mediated by TLR7 is likely to be involved in the pathogenesis of SLE. In mice with lupus caused by i.p...
  37. Mark J Shlomchik; Fiscal Year: 2014
    ..we showed that TLR9 was required for anti-DNA type ANAs and that RNA-associated autoantibodies required TLR7. Together these discoveries have led to a new understanding of the pathogenesis of autoimmune diseases, as well as ..
  38. TLR-7 Agonists as Targeted Anti-inflammatory Agents in Arthritis
    MARY P CORR; Fiscal Year: 2013
    ..We have chosen to use a TLR7 agonist, as TLR7 is intracellular, and ligands must permeate the cell for activity...
  39. Yorgo Modis; Fiscal Year: 2015
    ..Viral RNA is recognized by!TLR3, TLR7 and TLR8, and microbial DNA is recognized by TLR9...
  40. PAUL CAMILLE TUMEH; Fiscal Year: 2015
    ..system that integrates/encapsulates the model antigen ovalbumin (OVA) and the adjuvant Toll-Like-Receptor-7 (TLR7)-agonist imiquimod (IMQ), generating OVA/IMQ-NPSs...
  41. Lee Ann Garrett-Sinha; Fiscal Year: 2014
    ..Recently Toll- like receptor (TLR) signaling, particularly via TLR7 and TLR9, has been implicated in the activation of autoreactive B cells to differentiate into ASCs...
  42. Genotypic Variation and B. burgdorferi Pathogenesis
    Ira Schwartz; Fiscal Year: 2009
    ..recognized by phagocytic cells, leading to uptake and subsequent stimulation of type I IFN production via TLR7/9 signaling from within the phagolysosome and that the ability of a B...
  43. Argyrios N Theofilopoulos; Fiscal Year: 2014
    ..models, recently an ENU mutation in the Slc15a4 gene, called feeble, was discovered that resulted in defective TLR7/9-induced type I interferon production in specifically pDCs...
  44. Inhibitors of PI3K-delta for Treatment of Skin Inflammation
    Cristiana Guiducci; Fiscal Year: 2012
    ..Triggering of the innate receptors TLR7 and TLR9 by self nucleic acids in plasmacytoid dendritic cell (PDC) precursors and B cells is key in the ..
  45. Toll-Like Receptors in Systemic Autoimmune Disease
    Ann Marshak-Rothstein; Fiscal Year: 2013
    ..For example. Tolllike receptors 9 and 7 (TLR9, TLR7) can trigger responses to self nucleic acids...
  46. Photo-assisted targeting of immunotherapy to the bladder
    DIMITRI SIMBERG; Fiscal Year: 2013
    ..In the Carson laboratory, formulations of synthetic Toll-like receptor 7 ligands (TLR7) were found to be potent inducers of inflammation in the bladder, mimicking BCG treatment without resulting in any ..
  47. Anne Davidson; Fiscal Year: 2014
    ..Disease is accelerated in male W/B mice that carry the Yaa locus containing a reduplication of the TLR7 gene...
  48. Ian A Wilson; Fiscal Year: 2016
    ..have been accomplished by several groups, including our own, but major unresolved questions remain concerning how TLR7/8/9 interact with and are regulated by nucleic acid and other ligands in response to microbial pathogens...
  49. HIV-1 Replication and Pathogenesis in vivo
    Lishan Su; Fiscal Year: 2012
    ..signaling defects in pOC cells Second, we will define the role of each relevant receptor (CD4, CCR5, CXCR4, BDCA2, TLR7 and TLR9) in pDC activation with specific inhibitors and with genetic approaches...
  50. Regulation of the anti-phospholipid response in SLE
    Anne Davidson; Fiscal Year: 2009
    ..Disease is accelerated in male W/B mice that carry the Yaa locus containing a reduplication of the TLR7 gene...
  51. David B Jacoby; Fiscal Year: 2016
    ..We have demonstrated this effect in guinea pigs and mice, and in human airway tissues. TLR7 dependent broncho-dilation in guinea pigs and in human airways is mediated by production of nitric oxide, while ..
  52. Regulation of Type I Interferon Gene Expression in the Innate Immune Response
    Katherine A Fitzgerald; Fiscal Year: 2010
    ..These PRRs, which include both TLRs (TLR3, TLR7, TLR8 and TLR9) and cytoplasmic RNA helicases (RIG-I, Mda-5 and possibly others) are capable of detecting viral ..
  53. Bronchodilator Effects of Toll-Like Receptor-7 Agonists.
    David B Jacoby; Fiscal Year: 2011
    Our recent studies have demonstrated an entirely new and previously unrecognized effect of toll-like receptor 7 (TLR7) agonists in the airways, namely that they are potent bronchodilators, and prevent bronchoconstriction caused by ..
  54. Innate Immunity and Cancer Therapy
    SARAH ANNE COOLEY; Fiscal Year: 2011
    ..of haploidentical NK cell therapy to treat metastatic breast cancer, and Specific Aim 2 will test the efficacy of a TLR7 agonist against chronic lymphocytic leukemia...
  55. Peter D Katsikis; Fiscal Year: 2014
    ..A 14mer PDB we show here has no toxicity, is a potent inhibitor of HIV and has the advantage of being a TLR7/9 antagonist that inhibits HIV-induced IFN[unreadable] production...
  56. GREGG JOSHUA SILVERMAN; Fiscal Year: 2014
    ..block the pro-inflammatory effects of pathogenic IgG autoantibodies to nuclear antigens, postulated to trigger TLR7 and TLR9...
  57. Kei Yasuda; Fiscal Year: 2015
    ..mechanism whereby IRF5 might contribute to lupus pathogenesis is through its role in Toll-like receptor-7 (TLR7) and TLR9 signaling cascades...
  58. Role of toll like receptors (TLRs)in Gd contrast agent induced skin fibrosis
    Sergio A Jimenez; Fiscal Year: 2013
    ..activated macrophages are required to induce these lesions;and 3) the induction requires engagement of TLR4 and/or TLR7. To test these hypotheses, the following specific aims are proposed: SPECIFIC AIM 1: Induce fibrosis by GdBCA ..
  59. Silvia C Formenti; Fiscal Year: 2015
    ..2. Determine the effects of TLR7 agonist IMQ and RT on tumor-specific T cell immunity and tumor immune signature...
  60. Center for Lupus Research
    MARIA VIRGINIA PASCUAL; Fiscal Year: 2010
    ..on the role of monocytes, neutrophils and B cells in SLE pathogenesis, iv) Pre-clinical therapeutic value of TLR7/8/9 inhibitors...
  61. Mary P Stenzel-Poore; Fiscal Year: 2014
    ..Determine the optimal dose to achieve neuroprotective efficacy for TLR9 (K- and D-mix CpG ODNs) and TLR7 (IMQ) candidate drugs as prophylactic therapy in a NHP model of cortical stroke. Aim 2...
  62. The effect of innate immunity on B cell tolerance
    Thereza Imanishi-Kari; Fiscal Year: 2013
    ..has already made an important contribution to the emerging understanding of the role played by TLRs, in particular TLR7, in the development of SLE...
  63. MICROBES, DENDRITIC CELL SUBSETS AND T-CELL IMMUNITY
    Bali Pulendran; Fiscal Year: 2007
    ..tubercolosis, and the small synthetic molecules Pam3 Cys, and MALP], the TLR5 stimulus flagellin, the TLR7 stimuli imidazoquinolines, the TLR9 stimulus CpG DNA, and the TLR3 stimulus poly-I-C, as well as classic Th2 ..
  64. Enterovirus Pathogenesis
    VINCENT RACANIELLO; Fiscal Year: 2007
    ..We will determine the roles of TLR3, TLR7/8, RIG-I, and MDA-5 in sensing poliovirus replication in mice and in cultured cells...