TLR8

Summary

Gene Symbol: TLR8
Description: toll like receptor 8
Alias: CD288, toll-like receptor 8
Species: human
Products:     TLR8

Top Publications

  1. Morris G, Parker L, Ward J, Jones E, Whyte M, Brightling C, et al. Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses. FASEB J. 2006;20:2153-5 pubmed
    ..In keeping with these data, ASMC expressed TLR3 but not TLR7 or TLR8. Activation of ASMC by poly(I:C) induced a specific cytokine repertoire characterized by induction of CXCL10 ..
  2. Du X, Poltorak A, Wei Y, Beutler B. Three novel mammalian toll-like receptors: gene structure, expression, and evolution. Eur Cytokine Netw. 2000;11:362-71 pubmed
    We describe three novel genes, encoding members of the Toll-like receptor (Tlr) family (TLR7, TLR8, and TLR9). These Tlr family members, unlike others reported to date, were identified within a genomic database...
  3. Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, Akira S, et al. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science. 2004;303:1526-9 pubmed
    ..By using Toll-like receptor (TLR)-deficient mice and genetic complementation, we show that murine TLR7 and human TLR8 mediate species-specific recognition of GU-rich ssRNA...
  4. dos Santos B, Valverde J, Rohr P, Monticielo O, Brenol J, Xavier R, et al. TLR7/8/9 polymorphisms and their associations in systemic lupus erythematosus patients from southern Brazil. Lupus. 2012;21:302-9 pubmed publisher
    ..We analyzed the frequency of TLR7 rs179008, TLR8 rs3764880, TLR9 rs5743836 and rs352140 in 370 patients with SLE and 415 healthy controls from southern Brazil...
  5. Møller Larsen S, Nyegaard M, Haagerup A, Vestbo J, Kruse T, Børglum A. Association analysis identifies TLR7 and TLR8 as novel risk genes in asthma and related disorders. Thorax. 2008;63:1064-9 pubmed publisher
    ..Xp22 harbours the TLR7 and TLR8 genes...
  6. Saruta M, Targan S, Mei L, Ippoliti A, Taylor K, Rotter J. High-frequency haplotypes in the X chromosome locus TLR8 are associated with both CD and UC in females. Inflamm Bowel Dis. 2009;15:321-7 pubmed publisher
    ..Innate immune defects have been associated with CD, specifically CARD15/NOD2. Recently, Toll-like receptor 8 (TLR8) signaling has been shown to enhance generation of both cytokines...
  7. Gringhuis S, van der Vlist M, van den Berg L, den Dunnen J, Litjens M, Geijtenbeek T. HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells. Nat Immunol. 2010;11:419-26 pubmed publisher
    ..Here we show that HIV-1 required signaling by the PRRs Toll-like receptor 8 (TLR8) and DC-SIGN for replication in dendritic cells (DCs)...
  8. Ablasser A, Poeck H, Anz D, Berger M, Schlee M, Kim S, et al. Selection of molecular structure and delivery of RNA oligonucleotides to activate TLR7 versus TLR8 and to induce high amounts of IL-12p70 in primary human monocytes. J Immunol. 2009;182:6824-33 pubmed publisher
    ..In monocytes, the response to RNA oligonucleotides was mediated by either TLR8 or RIG-I...
  9. Larangé A, Antonios D, Pallardy M, Kerdine Romer S. TLR7 and TLR8 agonists trigger different signaling pathways for human dendritic cell maturation. J Leukoc Biol. 2009;85:673-83 pubmed publisher
    ..In particular, the intracellular TLR7 and TLR8, mediating the recognition of ssRNA by DCs, play a major role in the immune response during viral infection...
  10. Sacre S, Lo A, Gregory B, Simmonds R, Williams L, Feldmann M, et al. Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures. J Immunol. 2008;181:8002-9 pubmed
    ..The key observation that indicated the importance of TLR8 was the inhibition of spontaneous TNF production by imiquimod, which we discovered to be an inhibitor of TLR8...

Detail Information

Publications62

  1. Morris G, Parker L, Ward J, Jones E, Whyte M, Brightling C, et al. Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses. FASEB J. 2006;20:2153-5 pubmed
    ..In keeping with these data, ASMC expressed TLR3 but not TLR7 or TLR8. Activation of ASMC by poly(I:C) induced a specific cytokine repertoire characterized by induction of CXCL10 ..
  2. Du X, Poltorak A, Wei Y, Beutler B. Three novel mammalian toll-like receptors: gene structure, expression, and evolution. Eur Cytokine Netw. 2000;11:362-71 pubmed
    We describe three novel genes, encoding members of the Toll-like receptor (Tlr) family (TLR7, TLR8, and TLR9). These Tlr family members, unlike others reported to date, were identified within a genomic database...
  3. Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, Akira S, et al. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science. 2004;303:1526-9 pubmed
    ..By using Toll-like receptor (TLR)-deficient mice and genetic complementation, we show that murine TLR7 and human TLR8 mediate species-specific recognition of GU-rich ssRNA...
  4. dos Santos B, Valverde J, Rohr P, Monticielo O, Brenol J, Xavier R, et al. TLR7/8/9 polymorphisms and their associations in systemic lupus erythematosus patients from southern Brazil. Lupus. 2012;21:302-9 pubmed publisher
    ..We analyzed the frequency of TLR7 rs179008, TLR8 rs3764880, TLR9 rs5743836 and rs352140 in 370 patients with SLE and 415 healthy controls from southern Brazil...
  5. Møller Larsen S, Nyegaard M, Haagerup A, Vestbo J, Kruse T, Børglum A. Association analysis identifies TLR7 and TLR8 as novel risk genes in asthma and related disorders. Thorax. 2008;63:1064-9 pubmed publisher
    ..Xp22 harbours the TLR7 and TLR8 genes...
  6. Saruta M, Targan S, Mei L, Ippoliti A, Taylor K, Rotter J. High-frequency haplotypes in the X chromosome locus TLR8 are associated with both CD and UC in females. Inflamm Bowel Dis. 2009;15:321-7 pubmed publisher
    ..Innate immune defects have been associated with CD, specifically CARD15/NOD2. Recently, Toll-like receptor 8 (TLR8) signaling has been shown to enhance generation of both cytokines...
  7. Gringhuis S, van der Vlist M, van den Berg L, den Dunnen J, Litjens M, Geijtenbeek T. HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells. Nat Immunol. 2010;11:419-26 pubmed publisher
    ..Here we show that HIV-1 required signaling by the PRRs Toll-like receptor 8 (TLR8) and DC-SIGN for replication in dendritic cells (DCs)...
  8. Ablasser A, Poeck H, Anz D, Berger M, Schlee M, Kim S, et al. Selection of molecular structure and delivery of RNA oligonucleotides to activate TLR7 versus TLR8 and to induce high amounts of IL-12p70 in primary human monocytes. J Immunol. 2009;182:6824-33 pubmed publisher
    ..In monocytes, the response to RNA oligonucleotides was mediated by either TLR8 or RIG-I...
  9. Larangé A, Antonios D, Pallardy M, Kerdine Romer S. TLR7 and TLR8 agonists trigger different signaling pathways for human dendritic cell maturation. J Leukoc Biol. 2009;85:673-83 pubmed publisher
    ..In particular, the intracellular TLR7 and TLR8, mediating the recognition of ssRNA by DCs, play a major role in the immune response during viral infection...
  10. Sacre S, Lo A, Gregory B, Simmonds R, Williams L, Feldmann M, et al. Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures. J Immunol. 2008;181:8002-9 pubmed
    ..The key observation that indicated the importance of TLR8 was the inhibition of spontaneous TNF production by imiquimod, which we discovered to be an inhibitor of TLR8...
  11. Jurk M, Heil F, Vollmer J, Schetter C, Krieg A, Wagner H, et al. Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848. Nat Immunol. 2002;3:499 pubmed
  12. Georgel P, Macquin C, Bahram S. The heterogeneous allelic repertoire of human toll-like receptor (TLR) genes. PLoS ONE. 2009;4:e7803 pubmed publisher
    ..Hence this work depicts a first overview of the diversity of almost all human TLR genes, a prelude for large-scale population genetics as well as genetic association studies. ..
  13. Melchjorsen J, Jensen S, Malmgaard L, Rasmussen S, Weber F, Bowie A, et al. Activation of innate defense against a paramyxovirus is mediated by RIG-I and TLR7 and TLR8 in a cell-type-specific manner. J Virol. 2005;79:12944-51 pubmed
    ..RIG-I for activation of an antiviral response, myeloid cells utilized both the single-stranded RNA sensing TLR7 and TLR8 and dsRNA-dependent mechanisms independent of RIG-I, TLR3, and dsRNA-activated protein kinase R to trigger this ..
  14. Yang K, Puel A, Zhang S, Eidenschenk C, Ku C, Casrouge A, et al. Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses. Immunity. 2005;23:465-78 pubmed
    ..The TLR-7-, TLR-8-, and TLR-9-dependent induction of IFN-alpha/beta and -lambda is strictly IRAK-4 dependent and paradoxically redundant for protective immunity to most viruses in humans. ..
  15. Tanji H, Ohto U, Shibata T, Miyake K, Shimizu T. Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands. Science. 2013;339:1426-9 pubmed publisher
    Toll-like receptor 7 (TLR7) and TLR8 recognize single-stranded RNA and initiate innate immune responses...
  16. Bochud P, Hersberger M, Taffe P, Bochud M, Stein C, Rodrigues S, et al. Polymorphisms in Toll-like receptor 9 influence the clinical course of HIV-1 infection. AIDS. 2007;21:441-6 pubmed
    ..Because of its potential implications for intervention strategies and vaccine developments, additional epidemiological and experimental studies are needed to confirm this association. ..
  17. Miettinen M, Sareneva T, Julkunen I, Matikainen S. IFNs activate toll-like receptor gene expression in viral infections. Genes Immun. 2001;2:349-55 pubmed
    ..TLR1, TLR2, TLR4, TLR6, and TLR8 mRNAs were expressed at basal levels in macrophages...
  18. Cherfils Vicini J, Platonova S, Gillard M, Laurans L, Validire P, Caliandro R, et al. Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance. J Clin Invest. 2010;120:1285-97 pubmed publisher
    ..Here we have demonstrated expression of TLR7 and TLR8, the natural receptors for single-stranded RNA, by tumor cells in human lung cancer in situ and in human lung tumor ..
  19. Chuang T, Ulevitch R. Cloning and characterization of a sub-family of human toll-like receptors: hTLR7, hTLR8 and hTLR9. Eur Cytokine Netw. 2000;11:372-8 pubmed
    ..Expression of constitutively active hTLR7-9 stimulates an NF-kappaB signaling pathway indirectly supporting the contention that these receptors are involved in cellular responses to stimuli, which activate innate immunity. ..
  20. Cheng P, Eng H, Chou M, You H, Lin T. Genetic polymorphisms of viral infection-associated Toll-like receptors in Chinese population. Transl Res. 2007;150:311-8 pubmed
    ..single nucleotide polymorphisms (SNPs) in TLRs associated with viral infection, including TLR2, TLR3, TLR4, TLR7, TLR8, and TLR9...
  21. Kumar M, Adurthi S, Ramachandran S, Mukherjee G, Joy O, Krishnamurthy H, et al. Toll-like receptors 7, 8, and 9 expression and function in primary human cervical cancer Langerhans cells: evidence of anergy. Int J Gynecol Cancer. 2013;23:184-92 pubmed publisher
    ..We explored the status of expression and function of TLR7, TLR8, and TLR9 in primary human Langerhans cells (LCs) isolated from cervical tumors...
  22. Kariko K, Buckstein M, Ni H, Weissman D. Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA. Immunity. 2005;23:165-75 pubmed
    ..We show that RNA signals through human TLR3, TLR7, and TLR8, but incorporation of modified nucleosides m5C, m6A, m5U, s2U, or pseudouridine ablates activity...
  23. Peng G, Guo Z, Kiniwa Y, Voo K, Peng W, Fu T, et al. Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function. Science. 2005;309:1380-4 pubmed
    ..receptor (TLR) 8 signaling to the control of Treg cell function, in which synthetic and natural ligands for human TLR8 can reverse Treg cell function...
  24. Bauer S, Pigisch S, Hangel D, Kaufmann A, Hamm S. Recognition of nucleic acid and nucleic acid analogs by Toll-like receptors 7, 8 and 9. Immunobiology. 2008;213:315-28 pubmed publisher
    ..However, a role in the generation or perpetuation of autoimmune diseases such as systemic lupus erythematosus (SLE) has also been suggested. ..
  25. Steenholdt C, Andresen L, Pedersen G, Hansen A, Brynskov J. Expression and function of toll-like receptor 8 and Tollip in colonic epithelial cells from patients with inflammatory bowel disease. Scand J Gastroenterol. 2009;44:195-204 pubmed publisher
    ..Since the receptor is functionally active, our data suggest that TLR-8 signalling is important in the pathogenesis of IBD. ..
  26. Rao N, Nguyen S, Ngo K, Fung Leung W. A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in Toll/IL-1R-induced inflammatory signaling. Mol Cell Biol. 2005;25:6521-32 pubmed
    ....
  27. Liu J, Xu C, Hsu L, Luo Y, Xiang R, Chuang T. A five-amino-acid motif in the undefined region of the TLR8 ectodomain is required for species-specific ligand recognition. Mol Immunol. 2010;47:1083-90 pubmed publisher
    Toll-like receptors play important roles in regulating immunity against microbial infections. Toll-like receptor 8 (TLR8) belongs to a subfamily comprising TLR7, TLR8 and TLR9...
  28. Shayan G, Kansy B, Gibson S, Srivastava R, Bryan J, Bauman J, et al. A Phase Ib Study of Immune Biomarker Modulation with Neoadjuvant Cetuximab and TLR8 stimulation in Head and Neck Cancer to Overcome Suppressive Myeloid Signals. Clin Cancer Res. 2017;: pubmed publisher
    ..Since immunosuppression is common in HNSCC, we hypothesized that adding a pro-inflammatory TLR8 agonist to cetuximab therapy might result in enhanced T lymphocyte stimulation and anti-EGFR specific priming.
  29. Itoh H, Tatematsu M, Watanabe A, Iwano K, Funami K, Seya T, et al. UNC93B1 physically associates with human TLR8 and regulates TLR8-mediated signaling. PLoS ONE. 2011;6:e28500 pubmed publisher
    ..b>TLR8 is phylogenetically and structurally related to TLR7 and TLR9, but little is known about its localization or ..
  30. Larson P, Kucaba T, Xiong Z, Olin M, Griffith T, Ferguson D. Design and Synthesis of N1-Modified Imidazoquinoline Agonists for Selective Activation of Toll-like Receptors 7 and 8. ACS Med Chem Lett. 2017;8:1148-1152 pubmed publisher
    ..Results are presented showing both TLR7/8 activations are highly correlated to N1-substitution, with TLR8 selectivity achieved through inclusion of an ethyl-, propyl-, or butylamino group at this position...
  31. Yanagisawa S, Koarai A, Sugiura H, Ichikawa T, Kanda M, Tanaka R, et al. Oxidative stress augments toll-like receptor 8 mediated neutrophilic responses in healthy subjects. Respir Res. 2009;10:50 pubmed publisher
    ..Among these receptors, TLR8 has been reported as a key receptor that recognizes single-strand RNA virus...
  32. Jiang H, Li J, Li L, Zhang X, Yuan L, Chen J. Selective evolution of Toll-like receptors 3, 7, 8, and 9 in bats. Immunogenetics. 2017;69:271-285 pubmed publisher
    ..The coding sequences of TLR3, TLR7, TLR8, and TLR9 were sequenced in ten bats...
  33. Cervantes J, La Vake C, Weinerman B, Luu S, O Connell C, Verardi P, et al. Human TLR8 is activated upon recognition of Borrelia burgdorferi RNA in the phagosome of human monocytes. J Leukoc Biol. 2013;94:1231-41 pubmed publisher
    ..Bb), the Lyme disease spirochete, induces a robust and complex innate immune response in human monocytes, in which TLR8 cooperates with TLR2 in the induction of NF-κB-mediated cytokine production, whereas TLR8 is solely responsible ..
  34. Kastelijn E, van Moorsel C, Rijkers G, Ruven H, Karthaus V, Kwakkel van Erp J, et al. Polymorphisms in innate immunity genes associated with development of bronchiolitis obliterans after lung transplantation. J Heart Lung Transplant. 2010;29:665-71 pubmed publisher
    ..Polymorphisms in TLR2, TLR4 and TLR9 that recognize bacterial and viral pathogens are associated with BOS after lung transplantation. ..
  35. Triantafilou K, Vakakis E, Orthopoulos G, Ahmed M, Schumann C, Lepper P, et al. TLR8 and TLR7 are involved in the host's immune response to human parechovirus 1. Eur J Immunol. 2005;35:2416-23 pubmed
    ..In this study we show that mainly TLR8 and also TLR7 act as the host sensors for human parechovirus 1, a single-stranded RNA (ssRNA) virus...
  36. Brown V, Brown R, Ozinsky A, Hesselberth J, Fields S. Binding specificity of Toll-like receptor cytoplasmic domains. Eur J Immunol. 2006;36:742-53 pubmed
    ..In summary, interactions between the TLR, MyD88, and novel associated proteins have been characterized. ..
  37. Zhou Y, Ye L, Wan Q, Zhou L, Wang X, Li J, et al. Activation of Toll-like receptors inhibits herpes simplex virus-1 infection of human neuronal cells. J Neurosci Res. 2009;87:2916-25 pubmed publisher
    ..Human neuronal cells expressed TLR family members 1-10 and IFN-alpha/beta. The activation of TLR3 or TLR8 by double-stranded RNA (poly-I:C) or single-stranded RNA (ssRNA) induced IFN-alpha/beta expression...
  38. Zhang Z, Ohto U, Shibata T, Krayukhina E, Taoka M, Yamauchi Y, et al. Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA. Immunity. 2016;45:737-748 pubmed publisher
    ..The first site conserved in TLR7 and TLR8 was used for small ligand-binding essential for its activation...
  39. Wang C, Chang S, Wu Y, Lin J, Ho H, Chou T, et al. Genetic variations in Toll-like receptors (TLRs 3/7/8) are associated with systemic lupus erythematosus in a Taiwanese population. Sci Rep. 2014;4:3792 pubmed publisher
    ..Six SNPs of TLR3, TLR7, and TLR8 were genotyped to determine their associations with systemic lupus erythematosus (SLE) and clinical manifestations ..
  40. Tatematsu M, Funami K, Ishii N, Seya T, Obuse C, Matsumoto M. LRRC59 Regulates Trafficking of Nucleic Acid-Sensing TLRs from the Endoplasmic Reticulum via Association with UNC93B1. J Immunol. 2015;195:4933-42 pubmed publisher
    ..These findings help us understand how NA-sensing TLRs control their proper distribution in the infection/inflammatory state. ..
  41. Wang C, Eng H, Lin K, Chang C, Hsieh C, Lin Y, et al. TLR7 and TLR8 gene variations and susceptibility to hepatitis C virus infection. PLoS ONE. 2011;6:e26235 pubmed publisher
    ..We previously evaluated associations between TLR7 and TLR8 gene SNPs and susceptibility to hepatitis C virus (HCV) infection...
  42. Jefferies C, Doyle S, Brunner C, Dunne A, Brint E, Wietek C, et al. Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4. J Biol Chem. 2003;278:26258-64 pubmed
    ..Detailed analysis of the interaction between Btk and TLR8 demonstrates that the presence of both Box 2 and 3 motifs in the Toll/interleukin-1 receptor domain was required ..
  43. Nouri Shirazi M, Tamjidi S, Nourishirazi E, Guinet E. TLR8 combined withTLR3 or TLR4 agonists enhances DC-NK driven effector Tc1 cells. Immunol Lett. 2017;: pubmed publisher
    ..These studies suggest that combining more than one of TLR ligands enhances the magnitude of immune responses to cancer and infectious disease...
  44. Wang J, Shao Y, Bennett T, Shankar R, Wightman P, Reddy L. The functional effects of physical interactions among Toll-like receptors 7, 8, and 9. J Biol Chem. 2006;281:37427-34 pubmed
    ..The other TLRs that are evolutionarily closely related and highly homologous are TLR7, TLR8, and TLR9...