TNF-alpha

Summary

Gene Symbol: TNF-alpha
Description: tumor necrosis factor
Alias: DIF, TNF-alpha, TNFA, TNFSF2, TNLG1F, tumor necrosis factor, APC1 protein, TNF, macrophage-derived, TNF, monocyte-derived, TNF-a, cachectin, tumor necrosis factor ligand 1F, tumor necrosis factor ligand superfamily member 2, tumor necrosis factor-alpha
Species: human
Products:     TNF-alpha

Top Publications

  1. Papadopoulou E, Tripsianis G, Anagnostopoulos K, Tentes I, Kakolyris S, Galazios G, et al. Significance of serum tumor necrosis factor-alpha and its combination with HER-2 codon 655 polymorphism in the diagnosis and prognosis of breast cancer. Int J Biol Markers. 2010;25:126-35 pubmed
    ..The present study was conducted to clarify the diagnostic and prognostic significance of TNF-alpha and its combination with HER-2 Ile655Val SNP in breast cancer...
  2. Holler N, Zaru R, Micheau O, Thome M, Attinger A, Valitutti S, et al. Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat Immunol. 2000;1:489-95 pubmed
    ..RIP is also required for necrotic death induced by tumor necrosis factor (TNF) and TNF-related apoptosis-inducing ligand (TRAIL)...
  3. Liu H, Lin Y, Wu J, Sun H, Gong Z, Hu P, et al. Impact of genetic polymorphisms of leptin and TNF-alpha on rosiglitazone response in Chinese patients with type 2 diabetes. Eur J Clin Pharmacol. 2008;64:663-71 pubmed publisher
    Leptin and tumor necrosis factor-alpha (TNF-alpha) play important role in homeostasis and insulin resistance in the treatment of Type 2 diabetes (T2DM)...
  4. Kumaramanickavel G, Sripriya S, Vellanki R, Upadyay N, Badrinath S, Arokiasamy T, et al. Tumor necrosis factor allelic polymorphism with diabetic retinopathy in India. Diabetes Res Clin Pract. 2001;54:89-94 pubmed
    The association of tumor necrosis factor (TNF) with diabetic retinopathy (DR) has been described previously. A total of 207 Asian Indian patients of 15-year duration of type 2 diabetes were identified...
  5. Li C, Wang G, Gao Y, Liu L, Gao T. TNF-alpha gene promoter -238G>A and -308G>A polymorphisms alter risk of psoriasis vulgaris: a meta-analysis. J Invest Dermatol. 2007;127:1886-92 pubmed
    b>Tumor necrosis factor-alpha (TNF-alpha) is a major proinflammatory cytokine and involved in the etiology of psoriasis...
  6. Morgan D, Dominguez R, Keku T, Heidt P, Martin C, Galanko J, et al. Gastric cancer and the high combination prevalence of host cytokine genotypes and Helicobacter pylori in Honduras. Clin Gastroenterol Hepatol. 2006;4:1103-11 pubmed
    ..Interleukin (IL)-Ibeta-511, IL-1RN, IL-10-1082, and tumor necrosis factor-alpha-308 genotypes were determined...
  7. Crider K, Whitehead N, Buus R. Genetic variation associated with preterm birth: a HuGE review. Genet Med. 2005;7:593-604 pubmed
    ..Studies of a polymorphism in tumor necrosis factor-alpha, a proinflammatory cytokine, showed the most consistent increase in the risk of PTB...
  8. Mugnier B, Balandraud N, Darque A, Roudier C, Roudier J, Reviron D. Polymorphism at position -308 of the tumor necrosis factor alpha gene influences outcome of infliximab therapy in rheumatoid arthritis. Arthritis Rheum. 2003;48:1849-52 pubmed
    To test whether the G-to-A polymorphism at position -308 in the promoter of the tumor necrosis factor alpha (TNFalpha) gene influences response to infliximab therapy in patients with rheumatoid arthritis (RA)...
  9. Wang Y, Lan J, Yang L, Wang De J, Kuang J. TNF-? and IL-1RA polymorphisms and silicosis susceptibility in Chinese workers exposed to silica particles: a case-control study. Biomed Environ Sci. 2012;25:517-25 pubmed publisher
    ..Further independent studies on the interaction between SNPs and exposure to silica particles with a larger sample size are therefore warranted. ..
  10. Dourmishev L, Kamenarska Z, Hristova M, Dodova R, Kaneva R, Mitev V. Association of TNF-? polymorphisms with adult dermatomyositis and systemic lupus erythematosus in Bulgarian patients. Int J Dermatol. 2012;51:1467-73 pubmed publisher
    Single-nucleotide polymorphisms (SNPs) of tumor necrosis factor-alpha (TNF-?) have been implicated in various autoimmune diseases; however, the results are quite controversial, and there is still no widely accepted opinion about their ..

Detail Information

Publications62

  1. Papadopoulou E, Tripsianis G, Anagnostopoulos K, Tentes I, Kakolyris S, Galazios G, et al. Significance of serum tumor necrosis factor-alpha and its combination with HER-2 codon 655 polymorphism in the diagnosis and prognosis of breast cancer. Int J Biol Markers. 2010;25:126-35 pubmed
    ..The present study was conducted to clarify the diagnostic and prognostic significance of TNF-alpha and its combination with HER-2 Ile655Val SNP in breast cancer...
  2. Holler N, Zaru R, Micheau O, Thome M, Attinger A, Valitutti S, et al. Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat Immunol. 2000;1:489-95 pubmed
    ..RIP is also required for necrotic death induced by tumor necrosis factor (TNF) and TNF-related apoptosis-inducing ligand (TRAIL)...
  3. Liu H, Lin Y, Wu J, Sun H, Gong Z, Hu P, et al. Impact of genetic polymorphisms of leptin and TNF-alpha on rosiglitazone response in Chinese patients with type 2 diabetes. Eur J Clin Pharmacol. 2008;64:663-71 pubmed publisher
    Leptin and tumor necrosis factor-alpha (TNF-alpha) play important role in homeostasis and insulin resistance in the treatment of Type 2 diabetes (T2DM)...
  4. Kumaramanickavel G, Sripriya S, Vellanki R, Upadyay N, Badrinath S, Arokiasamy T, et al. Tumor necrosis factor allelic polymorphism with diabetic retinopathy in India. Diabetes Res Clin Pract. 2001;54:89-94 pubmed
    The association of tumor necrosis factor (TNF) with diabetic retinopathy (DR) has been described previously. A total of 207 Asian Indian patients of 15-year duration of type 2 diabetes were identified...
  5. Li C, Wang G, Gao Y, Liu L, Gao T. TNF-alpha gene promoter -238G>A and -308G>A polymorphisms alter risk of psoriasis vulgaris: a meta-analysis. J Invest Dermatol. 2007;127:1886-92 pubmed
    b>Tumor necrosis factor-alpha (TNF-alpha) is a major proinflammatory cytokine and involved in the etiology of psoriasis...
  6. Morgan D, Dominguez R, Keku T, Heidt P, Martin C, Galanko J, et al. Gastric cancer and the high combination prevalence of host cytokine genotypes and Helicobacter pylori in Honduras. Clin Gastroenterol Hepatol. 2006;4:1103-11 pubmed
    ..Interleukin (IL)-Ibeta-511, IL-1RN, IL-10-1082, and tumor necrosis factor-alpha-308 genotypes were determined...
  7. Crider K, Whitehead N, Buus R. Genetic variation associated with preterm birth: a HuGE review. Genet Med. 2005;7:593-604 pubmed
    ..Studies of a polymorphism in tumor necrosis factor-alpha, a proinflammatory cytokine, showed the most consistent increase in the risk of PTB...
  8. Mugnier B, Balandraud N, Darque A, Roudier C, Roudier J, Reviron D. Polymorphism at position -308 of the tumor necrosis factor alpha gene influences outcome of infliximab therapy in rheumatoid arthritis. Arthritis Rheum. 2003;48:1849-52 pubmed
    To test whether the G-to-A polymorphism at position -308 in the promoter of the tumor necrosis factor alpha (TNFalpha) gene influences response to infliximab therapy in patients with rheumatoid arthritis (RA)...
  9. Wang Y, Lan J, Yang L, Wang De J, Kuang J. TNF-? and IL-1RA polymorphisms and silicosis susceptibility in Chinese workers exposed to silica particles: a case-control study. Biomed Environ Sci. 2012;25:517-25 pubmed publisher
    ..Further independent studies on the interaction between SNPs and exposure to silica particles with a larger sample size are therefore warranted. ..
  10. Dourmishev L, Kamenarska Z, Hristova M, Dodova R, Kaneva R, Mitev V. Association of TNF-? polymorphisms with adult dermatomyositis and systemic lupus erythematosus in Bulgarian patients. Int J Dermatol. 2012;51:1467-73 pubmed publisher
    Single-nucleotide polymorphisms (SNPs) of tumor necrosis factor-alpha (TNF-?) have been implicated in various autoimmune diseases; however, the results are quite controversial, and there is still no widely accepted opinion about their ..
  11. Helmig S, Aliahmadi N, Schneider J. Tumour necrosis factor-alpha gene polymorphisms in asbestos-induced diseases. Biomarkers. 2010;15:400-9 pubmed publisher
    ..89; 95% CI 1.49-10.17; p = 0.006) with asbestos-induced lung cancer patients. The results confirm the hypothesis that TNF-alpha polymorphisms are associated with asbestos-induced fibrotic or malignant lung diseases in Germans...
  12. Zou Y, Feng X, Pan F, Su H, Tao J, Ye D. Meta-analysis of TNF-alpha promoter - 238A/G polymorphism and SLE susceptibility. Autoimmunity. 2010;43:264-74 pubmed publisher
    The tumor necrosis factor-alpha (TNF-alpha) promoter--238A/G polymorphism has been repeatedly associated with systemic lupus erythematosus (SLE), but findings are not consistent across studies...
  13. Kim H, Kang M, Lee S, Jin H, Kim J, Kim B, et al. Combined effect of tumour necrosis factor-alpha and interleukin-13 polymorphisms on bronchial hyperresponsiveness in Korean children with asthma. Clin Exp Allergy. 2008;38:774-80 pubmed publisher
    ..In addition, there appears to be a synergistic effect between the TNF-alpha promoter polymorphism and an IL-13 coding region polymorphism in terms of asthma susceptibility and BHR in this population. ..
  14. Shin H, Park B, Kim L, Jung J, Wang H, Kim Y, et al. Association of tumor necrosis factor polymorphisms with asthma and serum total IgE. Hum Mol Genet. 2004;13:397-403 pubmed
    Tumor necrosis factors (TNF; TNFA and TNFB) are major pro-inflammatory cytokines that are thought to be important in the pathogenesis of asthma...
  15. Nishimura M, Obayashi H, Mizuta I, Hara H, Adachi T, Ohta M, et al. TNF, TNF receptor type 1, and allograft inflammatory factor-1 gene polymorphisms in Japanese patients with type 1 diabetes. Hum Immunol. 2003;64:302-9 pubmed
    ..Because it contains many genes related to inflammatory and immune responses, including tumor necrosis factor (TNF), lymphotoxin-alpha (LT-alpha), and allograft inflammatory factor 1 (AIF-1) genes, it is unclear ..
  16. Till A, Rosenstiel P, Krippner Heidenreich A, Mascheretti Croucher S, Croucher P, Schäfer H, et al. The Met-196 -> Arg variation of human tumor necrosis factor receptor 2 (TNFR2) affects TNF-alpha-induced apoptosis by impaired NF-kappaB signaling and target gene expression. J Biol Chem. 2005;280:5994-6004 pubmed
    b>Tumor necrosis factor-alpha (TNF-alpha)-induced signaling is pivotally involved in the pathogenesis of chronic inflammatory diseases...
  17. Plomgaard P, Nielsen A, Fischer C, Mortensen O, Broholm C, Penkowa M, et al. Associations between insulin resistance and TNF-alpha in plasma, skeletal muscle and adipose tissue in humans with and without type 2 diabetes. Diabetologia. 2007;50:2562-71 pubmed
    ..However, findings on the TNF-alpha protein levels in plasma and skeletal muscle indicate that measurement of TNF mRNA content in adipose or muscle tissue provides no information with regard to the degree of insulin resistance. ..
  18. Zhang J, Dou C, Song Y, Ji C, Gu S, Xie Y, et al. Polymorphisms of tumor necrosis factor-alpha are associated with increased susceptibility to gastric cancer: a meta-analysis. J Hum Genet. 2008;53:479-89 pubmed publisher
    We conducted a meta-analysis to assess the association between tumor necrosis factor-alpha (TNF-alpha) gene TNFA-308 (G > A) and TNFA-857 (C > T) polymorphisms and gastric cancer (GC) susceptibility...
  19. Niewczas M, Ficociello L, Johnson A, Walker W, Rosolowsky E, Roshan B, et al. Serum concentrations of markers of TNFalpha and Fas-mediated pathways and renal function in nonproteinuric patients with type 1 diabetes. Clin J Am Soc Nephrol. 2009;4:62-70 pubmed publisher
    ..We measured markers of the tumor necrosis factor alpha (TNFalpha) pathway [TNFalpha, soluble TNF receptor 1 (sTNFR1), and 2 (sTNFR2)], its downstream ..
  20. Maury C, Liljestrom M, Laiho K, Tiitinen S, Kaarela K, Hurme M. Tumor necrosis factor alpha, its soluble receptor I, and -308 gene promoter polymorphism in patients with rheumatoid arthritis with or without amyloidosis: implications for the pathogenesis of nephropathy and anemia of chronic disease in reactive amy. Arthritis Rheum. 2003;48:3068-76 pubmed
    To study tumor necrosis factor alpha (TNFalpha) -308 gene promoter polymorphism and circulating levels of TNFalpha and soluble TNF receptor type I (sTNFRI) in rheumatoid arthritis (RA) patients with and without reactive amyloidosis...
  21. Mei Q, Xu J, Cao H, Bao D, Hu N, Zhang L, et al. Associations of the IL-1 and TNF gene polymorphisms in the susceptibility to duodenal ulcer disease in Chinese Han population. Int J Immunogenet. 2010;37:9-12 pubmed publisher
    ..pylori positivity. These findings show that no evidence for the involvement of a proinflammatory polymorphism in the IL-1Beta-511, IL-1RN and TNF-A-308 in the susceptibility to DU in China. ..
  22. Kotsaki A, Raftogiannis M, Routsi C, Baziaka F, Kotanidou A, Antonopoulou A, et al. Genetic polymorphisms within tumor necrosis factor gene promoter region: a role for susceptibility to ventilator-associated pneumonia. Cytokine. 2012;59:358-63 pubmed publisher
    ..studies regarding the impact of single nucleotide polymorphisms (SNPs) within the promoter region of the tumor necrosis factor (TNF) gene for susceptibility to infections...
  23. Richardson A, Sisay Joof F, Ackerman H, Usen S, Katundu P, Taylor T, et al. Nucleotide diversity of the TNF gene region in an African village. Genes Immun. 2001;2:343-8 pubmed
    ..007). We conclude that, at the TNF locus, the nucleotide diversity found within a single African village is similar to the global value for human autosomal genes sampled across different continents. ..
  24. Koch W, Tiroch K, von Beckerath N, Schomig A, Kastrati A. Tumor necrosis factor-alpha, lymphotoxin-alpha, and interleukin-10 gene polymorphisms and restenosis after coronary artery stenting. Cytokine. 2003;24:161-71 pubmed
    ..The cytokines tumor necrosis factor (TNF)-alpha, lymphotoxin (LT)-alpha, and interleukin (IL)-10 are critically involved in inflammatory ..
  25. Sprowl J, Reed K, Armstrong S, Lanner C, Guo B, Kalatskaya I, et al. Alterations in tumor necrosis factor signaling pathways are associated with cytotoxicity and resistance to taxanes: a study in isogenic resistant tumor cells. Breast Cancer Res. 2012;14:R2 pubmed
    ..Paclitaxel has been shown to induce soluble tumor necrosis factor alpha (sTNF-?) production in macrophages, but the involvement of TNF production in taxane cytotoxicity or ..
  26. Endeman H, Meijvis S, Rijkers G, van Velzen Blad H, van Moorsel C, Grutters J, et al. Systemic cytokine response in patients with community-acquired pneumonia. Eur Respir J. 2011;37:1431-8 pubmed publisher
    ..IL-1RA, IL-6, IL-8 and IL-10 are acute phase proteins, independent of genotype. Their levels are influenced by the nature of the causative microorganism and the start of corticosteroids therapy. ..
  27. Reid J, Simpson N, Walker R, Economidou O, Shillito J, Gooi H, et al. The carriage of pro-inflammatory cytokine gene polymorphisms in recurrent pregnancy loss. Am J Reprod Immunol. 2001;45:35-40 pubmed
    ..The genes for interleukin-1 beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) carry functional gene polymorphisms...
  28. Azizah M, Kuak S, Ainol S, Rahim M, Normaznah Y, Norella K. Association of the tumor necrosis factor alpha gene polymorphism with susceptibility and clinical-immunological findings of systemic lupus erythematosus. Asian Pac J Allergy Immunol. 2004;22:159-63 pubmed
    ..The tumor necrosis factor alpha (TNFa) gene, encoded at the TNF locus in the MHC class III region, is now known to be an important ..
  29. Pantelidis P, Fanning G, Wells A, Welsh K, du Bois R. Analysis of tumor necrosis factor-alpha, lymphotoxin-alpha, tumor necrosis factor receptor II, and interleukin-6 polymorphisms in patients with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2001;163:1432-6 pubmed
    ..In the present study, we examined 12 biallelic polymorphisms in the genes for tumor necrosis factor (TNF)-alpha (+488[G/A], -238[G/A], -308[G/A]), lymphotoxin (LT)-alpha (+720[C/A], +365[C/G], and +249[A/G],..
  30. Clausen T, Kaastrup P, Stallknecht B. Proinflammatory tissue response and recovery of adipokines during 4 days of subcutaneous large-pore microdialysis. J Pharmacol Toxicol Methods. 2009;60:281-7 pubmed publisher
    ..Insertion of a large-pore microdialysis catheter into human SAT results in tissue trauma leading to changes in the interstitial concentrations of IL-1beta, IL-6, IL-8, MCP-1, TNF-alpha and adiponectin. ..
  31. Rath P, Aggarwal B. TNF-induced signaling in apoptosis. J Clin Immunol. 1999;19:350-64 pubmed
    ..This cascade also does not explain how type II TNF receptors which lack the death domain, induce apoptosis. Nevertheless, this review of apoptosis signaling will be limited to those proteins that makeup the cascade. ..
  32. Lin Y, Chen R, Wan L, Sheu J, Huang C, Lin C, et al. Association of TNF-alpha gene polymorphisms with systemic lupus erythematosus in Taiwanese patients. Lupus. 2009;18:974-9 pubmed publisher
    ..031; photosensitivity, P = 0.044). These results suggest that TNF-alpha genetic polymorphisms contribute to SLE susceptibility in the Taiwanese population. ..
  33. Wu F, Qu Y, Tang Y, Cao D, Sun P, Xia Z. Lack of association between cytokine gene polymorphisms and silicosis and pulmonary tuberculosis in Chinese iron miners. J Occup Health. 2008;50:445-54 pubmed
    ..The aims of the current investigation were to determine whether functional polymorphisms in the tumor necrosis factor-alpha (TNF-alpha) gene at position -308; in the transforming growth factor-beta 1 (TGF-beta1) gene at ..
  34. Hamajima N, Shibata A, Katsuda N, Matsuo K, Ito H, Saito T, et al. Subjects with TNF-A-857TT and -1031TT genotypes showed the highest Helicobacter pylori seropositive rate compared with those with other genotypes. Gastric Cancer. 2003;6:230-6 pubmed
    A possible association between Helicobacter pylori seropositivity and tumor necrosis factor (TNF) a G-308A has been reported in Korea. The present study examined the associations of H...
  35. Furuta M, Yano Y, Ito K, Gabazza E, Katsuki A, Tanaka T, et al. Relationship of the tumor necrosis factor-alpha -308 A/G promoter polymorphism with insulin sensitivity and abdominal fat distribution in Japanese patients with type 2 diabetes mellitus. Diabetes Res Clin Pract. 2002;56:141-5 pubmed
    We investigated the relationship of the A/G variant of the tumor necrosis factor-alpha (TNF-alpha) gene promoter at position -308 with insulin resistance and abdominal fat distribution in type 2 diabetic patients in the Japanese ..
  36. Dalziel B, Gosby A, Richman R, Bryson J, Caterson I. Association of the TNF-alpha -308 G/A promoter polymorphism with insulin resistance in obesity. Obes Res. 2002;10:401-7 pubmed
    Obesity is a major risk factor for the development of type 2 diabetes. Tumor necrosis factor (TNF)-alpha is a candidate gene for the development of both obesity and insulin resistance...
  37. Um J, Lee J, Joo J, Kim K, Lee E, Shin T, et al. Association between tumor necrosis factor-alpha gene polymorphism and Sasang constitution in cerebral infarction. Am J Chin Med. 2005;33:547-57 pubmed
    ..b>Tumor necrosis factor-alpha (TNF-alpha), a potent immunomodulator and pro-inflammatory cytokine, has been implicated in many ..
  38. Sohail M, Kaul A, Bali P, Raziuddin M, Singh M, Singh O, et al. Alleles -308A and -1031C in the TNF-alpha gene promoter do not increase the risk but associated with circulating levels of TNF-alpha and clinical features of vivax malaria in Indian patients. Mol Immunol. 2008;45:1682-92 pubmed
    ....
  39. Sargen K, Demaine A, Kingsnorth A. Cytokine gene polymorphisms in acute pancreatitis. JOP. 2000;1:24-35 pubmed
    ..METHODS, Three TNF microsatellite loci (TNFa, TNFb, TNFc), the TNF-308 polymorphism, the IL-10...
  40. Huang J, Liao N, HUANG Q, Xie Z. Association between tumor necrosis factor-?-308G/A polymorphism and obstructive sleep apnea: a meta-analysis. Genet Test Mol Biomarkers. 2012;16:246-51 pubmed publisher
    The tumor necrosis factor (TNF)-?-308G/A polymorphism has been implicated in susceptibility to obstructive sleep apnea (OSA). However, results from previous studies are inconsistent...
  41. Tekeli O, Turacli M, Egin Y, Akar N, Elhan A. Tumor necrosis factor alpha-308 gene polymorphism and pseudoexfoliation glaucoma. Mol Vis. 2008;14:1815-8 pubmed
    To investigate the possible association between tumor necrosis factor alpha (TNF-alpha)-308 G/A polymorphism and pseudoexfoliation (PEX) glaucoma...
  42. Menezo V, Bond S, Towler H, Kuo N, Baharlo B, Wilson A, et al. Cytokine gene polymorphisms involved in chronicity and complications of anterior uveitis. Cytokine. 2006;35:200-6 pubmed
    ..TaqMan PCR amplification was used to genotype five single nucleotide polymorphisms in cytokine genes; IL-1RN+2018, IL-6-174, IL-10-1082, TNF-238, TNF-308 and these were correlated with clinical phenotype...
  43. Ovsyannikova I, Ryan J, Vierkant R, O Byrne M, Pankratz V, Jacobson R, et al. Influence of host genetic variation on rubella-specific T cell cytokine responses following rubella vaccination. Vaccine. 2009;27:3359-66 pubmed publisher
    ....
  44. Aringer M, Smolen J. Tumour necrosis factor and other proinflammatory cytokines in systemic lupus erythematosus: a rationale for therapeutic intervention. Lupus. 2004;13:344-7 pubmed
    ..Therefore, anti-TNF alpha therapy may constitute an interesting candidate approach for treating SLE inflammatory organ disease, but ..
  45. Sharma S, Rathored J, Ghosh B, Sharma S. Genetic polymorphisms in TNF genes and tuberculosis in North Indians. BMC Infect Dis. 2010;10:165 pubmed publisher
    ..Of these, both tumor necrosis factor alpha (TNF-alpha) and lymphotoxin alpha (LT-alpha) play important immunoregulatory roles...
  46. Lee G, Choi Y, Kim S, Hong M, Oh S, Lim Y, et al. Association of tumor necrosis factor-{alpha} gene polymorphisms with advanced stage endometriosis. Hum Reprod. 2008;23:977-81 pubmed publisher
    ..whether specific haplotypes and several single nucleotide polymorphisms in the promoter region of the tumor necrosis factor (TNF)-alpha gene are associated with the risk of advanced stage endometriosis in a Korean population...
  47. Ghaderi M, Nikitina L, Peacock C, Hjelmstrom P, Hallmans G, Wiklund F, et al. Tumor necrosis factor a-11 and DR15-DQ6 (B*0602) haplotype increase the risk for cervical intraepithelial neoplasia in human papillomavirus 16 seropositive women in Northern Sweden. Cancer Epidemiol Biomarkers Prev. 2000;9:1067-70 pubmed
    ..The aim of this study was to analyze the association between CIN and a microsatellite polymorphism of tumor necrosis factor (TNFa) taking HPV exposure and CIN-associated HLA haplotypes into account...
  48. Yang Y, Sun R, Yang H, Zheng F, Gong F. -308 G > A of TNF-? gene promoter decreases the risk of multiple sclerosis: a meta-analysis. Mult Scler. 2011;17:658-65 pubmed publisher
    ..Polymorphisms of tumor necrosis factor (TNF)-? -308 were implicated in MS risk in several case-control association studies...
  49. Yea S, Yang Y, Jang W, Lee Y, Bae H, Paik K. Association between TNF-alpha promoter polymorphism and Helicobacter pylori cagA subtype infection. J Clin Pathol. 2001;54:703-6 pubmed
    ..TNF-alpha -308A polymorphism was significantly related to infection with the H pylori cagA subtype in Korean patients with gastric disease. ..
  50. Settin A, Hassan H, El Baz R, Hassan T. Association of cytokine gene polymorphisms with psoriasis in cases from the Nile Delta of Egypt. Acta Dermatovenerol Alp Pannonica Adriat. 2009;18:105-12 pubmed
    ..Genetic polymorphisms related to the IL6, IL10, and TNF-alpha genes showed a particular pattern of association with psoriasis that may have a potential impact on disease counseling and management. ..
  51. Trajkov D, Trajchevska M, Arsov T, Petlichkovski A, Strezova A, Efinska Mladenovska O, et al. Association of 22 cytokine gene polymorphisms with tuberculosis in Macedonians. Indian J Tuberc. 2009;56:117-31 pubmed
    ..These results suggest that some cytokine polymorphisms are significantly associated and affect host susceptibility/resistance to TB in Macedonians. ..
  52. Alakulppi N, Kyllönen L, Jäntti V, Matinlauri I, Partanen J, Salmela K, et al. Cytokine gene polymorphisms and risks of acute rejection and delayed graft function after kidney transplantation. Transplantation. 2004;78:1422-8 pubmed
    ..6, 95% CI 1.1-2.6, P = 0.040). Our results confirm that cytokine gene polymorphisms influence the outcome of kidney transplantation. Our data especially identify the TNF-alpha -308AA-genotype as a factor predisposing for AR episodes. ..
  53. Beghe B, Padoan M, Moss C, Barton S, Holloway J, Holgate S, et al. Lack of association of HLA class I genes and TNF alpha-308 polymorphism in toluene diisocyanate-induced asthma. Allergy. 2004;59:61-4 pubmed
    ..of TDI-induced asthma, we analyzed the distribution of human leukocyte antigen (HLA) class I genes and of tumor necrosis factor (TNF)-alpha A-308G polymorphism in 142 patients with TDI-induced asthma and in 50 asymptomatic exposed ..
  54. Shi K, Cai X, Xiao D, Wu S, Peng M, Lin X, et al. Tumour necrosis factor-?-857T allele reduces the risk of hepatitis B virus infection in an Asian population. J Viral Hepat. 2012;19:e66-72 pubmed publisher
    ..So, we draw the conclusion that the TNF-?-857T allele reduces the risk of chronic HBV infection in this Asian population. ..
  55. Wang C, Shen Y, Wei L, Lin K, Feng S, Yang Y, et al. Polymorphism in the TNF-?(-863) locus associated with reduced risk of primary open angle glaucoma. Mol Vis. 2012;18:779-85 pubmed
    b>Tumor necrosis factor-? (TNF-?), an important proinflammatory cytokine, exerts a variety of physiologic and pathogenic effects that lead to tissue destruction...
  56. Morris A, Heilbronn L, Noakes M, Kind K, Clifton P. -308 Nco I polymorphism of tumour necrosis factor alpha in overweight Caucasians. Diabetes Res Clin Pract. 2003;62:197-201 pubmed
    ..The AA variant at position -308 in the promoter region of the TNFalpha gene does not influence the amount of weight lost in overweight and obese men and women on a 30% energy restricted diet. ..
  57. Vatay A, Bene L, Kovacs A, Prohaszka Z, Szalai C, Romics L, et al. Relationship between the tumor necrosis factor alpha polymorphism and the serum C-reactive protein levels in inflammatory bowel disease. Immunogenetics. 2003;55:247-52 pubmed
    ..The aim of the study was to determine the prevalence of the tumor necrosis factor alpha (TNF-alpha) promoter polymorphisms at positions -238 and -308, and to measure the serum CRP levels in ..
  58. Vandenabeele P, Declercq W, Van Herreweghe F, Vanden Berghe T. The role of the kinases RIP1 and RIP3 in TNF-induced necrosis. Sci Signal. 2010;3:re4 pubmed publisher
    b>Tumor necrosis factor (TNF) is a pleiotropic molecule with a crucial role in cellular stress and inflammation during infection, tissue damage, and cancer...
  59. Mukhopadhyay S, Hoidal J, Mukherjee T. Role of TNFalpha in pulmonary pathophysiology. Respir Res. 2006;7:125 pubmed
    b>Tumor necrosis factor alpha (TNFalpha) is the most widely studied pleiotropic cytokine of the TNF superfamily...
  60. Tsytsykova A, Falvo J, Schmidt Supprian M, Courtois G, Thanos D, Goldfeld A. Post-induction, stimulus-specific regulation of tumor necrosis factor mRNA expression. J Biol Chem. 2007;282:11629-38 pubmed
    The tumor necrosis factor (TNF) gene is activated by multiple extracellular signals in a stimulus- and cell type-specific fashion...
  61. Densem C, Hutchinson I, Yonan N, Brooks N. Tumour necrosis factor alpha gene polymorphism: a predisposing factor to non-ischaemic myocardial dysfunction?. Heart. 2002;87:153-5 pubmed
    Tumour necrosis factor alpha (TNF alpha) is implicated in the pathophysiology of heart failure. Plasma TNF alpha is raised in patients with myocardial dysfunction in proportion to the symptoms...
  62. Sezgin M, Barlas I, Ankarali H, Altintaş Z, Turkmen E, Gokdogan T, et al. Tumour necrosis factor alpha -308G/A gene polymorphism: lack of association with knee osteoarthritis in a Turkish population. Clin Exp Rheumatol. 2008;26:763-8 pubmed
    ..05). These findings suggest that the examined polymorphism in the TNFalpha gene does not contribute to susceptibility to or severity of knee osteoarthritis in the Turkish population. ..