TRIM25

Summary

Gene Symbol: TRIM25
Description: tripartite motif containing 25
Alias: EFP, RNF147, Z147, ZNF147, E3 ubiquitin/ISG15 ligase TRIM25, RING finger protein 147, RING-type E3 ubiquitin transferase, RING-type E3 ubiquitin transferase TRIM25, estrogen-responsive finger protein, tripartite motif protein TRIM25, tripartite motif-containing protein 25, ubiquitin/ISG15-conjugating enzyme TRIM25, zinc finger protein 147 (estrogen-responsive finger protein), zinc finger protein-147
Species: human

Top Publications

  1. ncbi Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth
    Tomohiko Urano
    Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Nature 417:871-5. 2002
  2. ncbi IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
    Taro Kawai
    Exploratory Research for Advanced Technology, Japan Science and Technology Agency
    Nat Immunol 6:981-8. 2005
  3. ncbi A ubiquitin E3 ligase Efp is up-regulated by interferons and conjugated with ISG15
    Norie Nakasato
    Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan
    Biochem Biophys Res Commun 351:540-6. 2006
  4. ncbi TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity
    Michaela U Gack
    Department of Microbiology and Molecular Genetics and Tumor Virology Division, New England Primate Research Center, Harvard Medical School, 1 Pine Hill Drive, Southborough, Massachusetts 01772, USA
    Nature 446:916-920. 2007
  5. pmc Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction
    Michaela U Gack
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Harlyne J Norris Cancer Research Tower, 1450 Biggy Street, Los Angeles, CA 90033, USA
    Proc Natl Acad Sci U S A 105:16743-8. 2008
  6. doi Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection
    Hiroyuki Oshiumi
    Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Biol Chem 284:807-17. 2009
  7. pmc Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I
    Michaela Ulrike Gack
    Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Cell Host Microbe 5:439-49. 2009
  8. pmc REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid-inducible gene-I
    Dong Gao
    Key Laboratory of Cell Proliferation and Differentiation Ministry of Education, College of Life Sciences, Peking University, Beijing, China
    PLoS ONE 4:e5760. 2009
  9. pmc Phosphorylation-mediated negative regulation of RIG-I antiviral activity
    Michaela U Gack
    Department of Microbiology and Molecular Genetics, New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Box 9102, Southborough, MA 01772 9102, USA
    J Virol 84:3220-9. 2010
  10. pmc Oestrogen causes degradation of KLF5 by inducing the E3 ubiquitin ligase EFP in ER-positive breast cancer cells
    Ke Wen Zhao
    Department of Hematology and Medical Oncology, School of Medicine, Emory University, Atlanta, GA 30322, USA
    Biochem J 437:323-33. 2011

Detail Information

Publications180 found, 100 shown here

  1. ncbi Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth
    Tomohiko Urano
    Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Nature 417:871-5. 2002
    ..b>Efp, a target gene product of ER alpha, is a member of the RING-finger B-box coiled-coil (RBCC) motif family...
  2. ncbi IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
    Taro Kawai
    Exploratory Research for Advanced Technology, Japan Science and Technology Agency
    Nat Immunol 6:981-8. 2005
    ..Knockdown' of IPS-1 by small interfering RNA blocked interferon induction by virus infection. Thus, IPS-1 is an adaptor involved in RIG-I- and Mda5-mediated antiviral immune responses...
  3. ncbi A ubiquitin E3 ligase Efp is up-regulated by interferons and conjugated with ISG15
    Norie Nakasato
    Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan
    Biochem Biophys Res Commun 351:540-6. 2006
    ..Here we demonstrate that Efp mRNA as well as protein expression could be up-regulated by Type I IFN in HeLa cells and HepG2 cells...
  4. ncbi TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity
    Michaela U Gack
    Department of Microbiology and Molecular Genetics and Tumor Virology Division, New England Primate Research Center, Harvard Medical School, 1 Pine Hill Drive, Southborough, Massachusetts 01772, USA
    Nature 446:916-920. 2007
    ..that the amino-terminal caspase recruitment domains (CARDs) of RIG-I undergo robust ubiquitination induced by TRIM25 in mammalian cells...
  5. pmc Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction
    Michaela U Gack
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Harlyne J Norris Cancer Research Tower, 1450 Biggy Street, Los Angeles, CA 90033, USA
    Proc Natl Acad Sci U S A 105:16743-8. 2008
    ..the N-terminal CARDs of RIG-I undergo the K(63)-linked ubiquitination induced by tripartite motif protein 25 (TRIM25), critical for the interaction of RIG-I with its downstream signaling partner MAVS/VISA/IPS-1/Cardif...
  6. doi Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection
    Hiroyuki Oshiumi
    Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Biol Chem 284:807-17. 2009
    ..Activation of RIG-I requires the ubiquitin ligase, TRIM25, which mediates lysine 63-linked polyubiquitination of the RIG-I N-terminal CARD-like region...
  7. pmc Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I
    Michaela Ulrike Gack
    Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Cell Host Microbe 5:439-49. 2009
    The ubiquitin ligase TRIM25 mediates Lysine 63-linked ubiquitination of the N-terminal CARD domains of the viral RNA sensor RIG-I to facilitate type I interferon (IFN) production and antiviral immunity...
  8. pmc REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid-inducible gene-I
    Dong Gao
    Key Laboratory of Cell Proliferation and Differentiation Ministry of Education, College of Life Sciences, Peking University, Beijing, China
    PLoS ONE 4:e5760. 2009
    ..These findings suggest that REUL is an E3 ubiquitin ligase of RIG-I and specifically stimulates RIG-I-mediated innate antiviral activity...
  9. pmc Phosphorylation-mediated negative regulation of RIG-I antiviral activity
    Michaela U Gack
    Department of Microbiology and Molecular Genetics, New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Box 9102, Southborough, MA 01772 9102, USA
    J Virol 84:3220-9. 2010
    ..of viral RNA, the Lys-172 residue of RIG-I undergoes ubiquitination induced by tripartite motif protein 25 (TRIM25), an essential protein for antiviral signal transduction...
  10. pmc Oestrogen causes degradation of KLF5 by inducing the E3 ubiquitin ligase EFP in ER-positive breast cancer cells
    Ke Wen Zhao
    Department of Hematology and Medical Oncology, School of Medicine, Emory University, Atlanta, GA 30322, USA
    Biochem J 437:323-33. 2011
    ..The oestrogen-inducible E3 ligase EFP (oestrogen-responsive finger protein) was identified as a key player in oestrogen-mediated degradation of KLF5, as ..
  11. doi Ubiquitin-mediated modulation of the cytoplasmic viral RNA sensor RIG-I
    Hiroyuki Oshiumi
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku Sapporo 060 8638, Japan
    J Biochem 151:5-11. 2012
    ..RIG-I activation is regulated by ubiquitination. Three ubiquitin ligases target the RIG-I protein. TRIM25 and Riplet ubiquitin ligases are positive regulators of RIG-I and deliver the K63-linked polyubiquitin moiety to ..
  12. pmc The mitochondrial targeting chaperone 14-3-3ε regulates a RIG-I translocon that mediates membrane association and innate antiviral immunity
    Helene Minyi Liu
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195 7950, USA
    Cell Host Microbe 11:528-37. 2012
    ..partner and essential component of a translocation complex or "translocon" containing RIG-I, 14-3-3ε, and the TRIM25 ubiquitin ligase...
  13. pmc Species-specific inhibition of RIG-I ubiquitination and IFN induction by the influenza A virus NS1 protein
    Ricardo Rajsbaum
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS Pathog 8:e1003059. 2012
    ..The NS1 protein inhibits type-I interferon (IFN) production partly by blocking the TRIM25 ubiquitin E3 ligase-mediated Lys63-linked ubiquitination of the viral RNA sensor RIG-I, required for its optimal ..
  14. pmc Cellular reporter screens for inhibitors of Burkholderia pseudomallei targets in Pseudomonas aeruginosa
    Donald T Moir
    Microbiotix, Inc, Worcester, MA, USA
    Trans R Soc Trop Med Hyg 102:S152-62. 2008
    ..IPTG levels varied from complete dependence (ftsQ, gyrA, glmU, secA) to slower growth in the absence of IPTG (coaD, efp, mesJ), to apparently normal growth in the absence of IPTG (ligA, lpxA, folA, ipk)...
  15. ncbi The longitudinal effects of fenfluramine-phentermine use
    Richard M Fleming
    Critical Care and Cardiology Section, Department of Internal Medicine, Sierra Nevada Veterans Affairs, Reno, NV, USA
    Angiology 58:353-9. 2007
    ..Valvular regurgitation was greatest among patients who had recently discontinued the use of Fen-Phen (EFP) with 57% of all valves having regurgitation, 87.5% of which were "mild...
  16. ncbi Helicobacter pylori in areas of gastric metaplasia in the gallbladder and isolation of H. pylori DNA from gallstones
    Vatsala Misra
    Department of Pathology, MLN Medical College, Allahabad, India
    Pathology 39:419-24. 2007
    ..To assess if the areas of gastric metaplasia in the gallbladder are colonised by Helicobacter pylori and to conduct a molecular study of gallstones for presence of H. pylori DNA...
  17. ncbi Protein signatures distinctive of chlamydial species: horizontal transfers of cell wall biosynthesis genes glmU from archaea to chlamydiae and murA between chlamydiae and Streptomyces
    Emma Griffiths
    Department of Biochemistry, McMaster University, Hamilton, Ontario, CanadaL8N 3Z5
    Microbiology 148:2541-9. 2002
    ..Additionally, a fragment of the murA gene from Waddlia chondrophila and the efp gene from Simkania negevensis, two chlamydia-like species, were also cloned and sequenced...
  18. doi Amplified fragment length polymorphism and multilocus sequence analysis-based genotypic relatedness among pathogenic variants of Xanthomonas citri pv. citri and Xanthomonas campestris pv. bilvae
    Lan Bui Thi Ngoc
    CIRAD, UMR Peuplements Végétaux et Bioagresseurs en Milieu Tropical CIRAD Université de la Réunion, Pole de protection des plantes, 7 chemin de l IRAT, 97410 Saint Pierre, La Reunion, France
    Int J Syst Evol Microbiol 60:515-25. 2010
    ..AFLP) and multilocus sequence analysis (MLSA) based on four partial housekeeping gene sequences (atpD, dnaK, efp and gyrB ) for the genotypic classification of Xanthomonas citri pv...
  19. pmc Menstrual cycle effects on sympathetic neural responses to upright tilt
    Qi Fu
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Dallas, TX 75231, USA
    J Physiol 587:2019-31. 2009
    ..30 deg for 6 min, 60 deg for 45 min or till presyncope) in 11 young men and 11 women during the early follicular (EFP) and mid-luteal phase (MLP) of the menstrual cycle...
  20. ncbi Down-regulation of the tumor suppressor protein 14-3-3sigma is a sporadic event in cancer of the breast
    Jose M A Moreira
    Department of Proteomics in Cancer, Institute of Cancer Biology and Danish Centre for Translational Breast Cancer Research, Danish Cancer Society, DK 2100 Copenhagen
    Mol Cell Proteomics 4:555-69. 2005
    ..Our data suggest that, contrary to what was previously thought, loss of expression of 14-3-3sigma protein is not a frequent event in breast tumorigenesis...
  21. pmc Predicting the pathway involved in post-translational modification of elongation factor P in a subset of bacterial species
    Marc Bailly
    Department of Microbiology and Cell Science, University of Florida, Gainesville, FL, USA
    Biol Direct 5:3. 2010
    ..The homologous lysine of EF-P is also modified to a spermidine derivative in Escherichia coli. However, the biosynthesis pathway of this modification in the bacterial EF-P is yet to be elucidated...
  22. ncbi Strychnine-induced epileptiform activity in hippocampal and neocortical slice preparations: suppression by the organic calcium antagonists verapamil and flunarizine
    H Straub
    Institut fur Physiologie, Universitat Munster, Germany
    Brain Res 773:173-80. 1997
    ..calcium currents through L-type channels contribute to strychnine-induced epileptiform field potentials (EFP)...
  23. ncbi Applying a traditional individual psychotherapy model to Equine-facilitated Psychotherapy (EFP): theory and method
    Jane Karol
    Bear Spot Foundation, Concord, USA
    Clin Child Psychol Psychiatry 12:77-90. 2007
    ..method of psychotherapy using horses to aid in the therapeutic process (Equine-facilitated Psychotherapy or EFP)...
  24. ncbi The gene encoding the elongation factor P protein is essential for viability and is required for protein synthesis
    H Aoki
    Banting and Best Department of Medical Research, Nucleic Acids, Protein Synthesis and Molecular Genetics, University of Toronto, Toronto, Ontario M5G 1L6, Canada
    J Biol Chem 272:32254-9. 1997
    Elongation factor P (EFP) is a protein that stimulates the peptidyltransferase activity of fully assembled 70 S prokaryotic ribosomes and enhances the synthesis of certain dipeptides initiated by N-formylmethionine...
  25. ncbi The lateral spread of epileptiform discharges in rat neocortical slices: effect of focal phencyclidine application
    A Gorji
    Institut fur Physiologie, Universitat Munster, 48149 Munster, Germany
    Pharmacopsychiatry 36:113-20. 2003
    ..were used to examine phencyclidine (PCP) effects on the lateral propagation of epileptiform field potentials (EFP) across adjacent areas of rat frontal neocortex...
  26. doi Preliminary phylogenetic identification of virulent Chlamydophila pecorum strains
    Khalil Yousef Mohamad
    INRA, UR1282 Infectiologie Animale et Santé Publique, F 37380 Nouzilly, France
    Infect Genet Evol 8:764-71. 2008
    ..6 potential virulence genes (ompA, incA, incB, incC, mip and copN), 5 housekeeping genes (recA, hemD, aroC, efp, gap), and the ORF663 gene encoding a hypothetical protein (HP) that includes a variant 15-nucleotides coding ..
  27. ncbi Epidemiology of onychomycosis and paronychia in the area of ANCONA (ITALY) over a period of 5 years
    O Simonetti
    Clinica Dermatologica, Ospedale Regionale, Via Conca 71, 60020, Torrette, Ancona, Italy
    Mycopathologia 158:271-4. 2004
    ..agents of these infections, an increasing prevalence of fungal infections due to emerging fungal pathogens (EFP) was noted throughout this time period...
  28. doi Catabolic pathways and cellular responses of Pseudomonas putida P8 during growth on benzoate with a proteomics approach
    Bin Cao
    Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore
    Biotechnol Bioeng 101:1297-312. 2008
    ..amino acid/protein and energy metabolism (isocitrate dehydrogenase, SucC, SucD, AcnB, GabD, ArcA, ArgI, Efp and periplasmic binding proteins of several ABC-transporters); and (iii) cell envelope and cell division (bacterial ..
  29. ncbi Is opioidergic activity responsible for the circadian variation observed in the gonadotrophin responsiveness of early follicular phase women?
    W G Rossmanith
    Department of Obstetrics Gynecology, University of Ulm, Germany
    Clin Endocrinol (Oxf) 49:499-503. 1998
    ..response to gonadotrophin-releasing hormone (GnRH) displays a circadian rhythm during the early follicular phase (EFP), with GnRH-stimulated luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release found to be markedly ..
  30. ncbi [Research of relationship between endoneurial fluid pressure and electroneurography of the facial nerve]
    Bing Chen
    Department of Otorhinolaryngology, Eye Ear Nose and Throat Hospital of Fudan University, Shanghai 200031, China
    Zhonghua Er Bi Yan Hou Ke Za Zhi 38:268-71. 2003
    The relationship between endoneurial fluid pressure (EFP) and electroneurography (ENoG) of the facial nerve was studied in order to evaluate the ENoG as the basis of pathophysiology of the decompression of the facial nerve.
  31. ncbi Glycosylated trypsin-like proteases from earthworm Eisenia fetida
    Jin Xia Wu
    College of Life Science, Hebei University, 180 Wusi East Road, Baoding City 071002, Hebei, China
    Int J Biol Macromol 40:399-406. 2007
    ..Here, eight glycosylated fibrinolytic proteases (EfP-0-1, EfP-0-2, EfP-I-1, EfP-I-2, EfP-II-1, EfP-II-2, EfP-III-1 and EfP-III-2) were isolated from an earthworm ..
  32. ncbi [Cloning, expression of fibrinolytic enzyme gene Efp-I from Eisenia fetida in Escherichia coli and activity analysis]
    Xiao Yu Zhao
    College of Life Sciences, Hebei University, Baoding 071002, China
    Sheng Wu Gong Cheng Xue Bao 23:452-6. 2007
    ..in which only one sequence, AY438624, whose translated protein had similar N-terminal amino-acid sequence to EfP-I purified from Eisenia fetida...
  33. doi The endocrine and follicular growth dynamics throughout the menstrual cycle in women with consistently or variably elevated early follicular phase FSH compared with controls
    C H de Koning
    Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, Vrije Universiteit Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Hum Reprod 23:1416-23. 2008
    Elevated early follicular phase (EFP) FSH is frequently observed in subfertile patients. In these women, temporary normalization of FSH concentrations is known to occur...
  34. doi What motivates farmers to participate in the Nova Scotia environmental farm plan program? Evidence and environmental policy implications
    Dominic O A Atari
    School for Resource and Environmental Studies, Dalhousie University, Halifax, Nova Scotia, Canada
    J Environ Manage 90:1269-79. 2009
    ..farmers' experience, and factors that affect farmer participation in the relatively new Environmental Farm Plan (EFP) program, implemented in several provinces in Canada...
  35. doi The assessment of lower urinary tract function in children with anorectal malformations before and after PSARP
    B Jindal
    Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, India
    Eur J Pediatr Surg 19:34-7. 2009
    ..Posterior sagittal anorectoplasty (PSARP) is believed to have a minimal deleterious effect on lower urinary tract function...
  36. doi Structure of large nitrate-water clusters at ambient temperatures: simulations with effective fragment potentials and force fields with implications for atmospheric chemistry
    Yifat Miller
    Department of Physical Chemistry and the Fritz Haber Research Center for Molecular Dynamics, Hebrew University, Jerusalem 91904, Israel
    J Phys Chem A 113:12805-14. 2009
    ..In addition, a comparison between the electronic structure based EFP and the classical force field description of the 32 water cluster system is presented...
  37. doi Knockdown of Efp by DNA-modified small interfering RNA inhibits breast cancer cell proliferation and in vivo tumor growth
    K Ueyama
    Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Hidaka, Saitama, Japan
    Cancer Gene Ther 17:624-32. 2010
    The estrogen-responsive gene Efp promotes the growth of breast cancer cells by stimulating the degradation of a negative cell-cycle regulator, 14-3-3sigma, and is hence considered a suitable molecular target for breast cancer therapy...
  38. ncbi Solvent effects on the electronic transitions of p-nitroaniline: a QM/EFP study
    Dmytro Kosenkov
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
    J Phys Chem A 115:392-401. 2011
    ..singles with perturbative doubles (CIS(D)) method while the solvent is treated by the effective fragment potential (EFP) method...
  39. doi Emotional facial palsy following striato-capsular infarction
    L Michel
    Department of Neurology, University Hospital, Nantes, France
    J Neurol Neurosurg Psychiatry 79:193-4. 2008
    Emotional facial palsy (EFP) is a rare condition in which facial paresis is only apparent during reflex movements of the hemiface, such as smiling and laughter...
  40. pmc The chvH locus of Agrobacterium encodes a homologue of an elongation factor involved in protein synthesis
    W T Peng
    Department of Microbiology, University of Washington, Seattle, Washington 98195 7242, USA
    J Bacteriol 183:36-45. 2001
    ..The E. coli efp gene complemented detergent sensitivity, virulence, and expression of VirE2 in the chvH mutant, suggesting that ..
  41. ncbi A novel eIF5A complex functions as a regulator of p53 and p53-dependent apoptosis
    Ai Ling Li
    Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing, China
    J Biol Chem 279:49251-8. 2004
    ..Overexpression of eIF5A or its EFP domain resulted in up-regulation of p53, and silencing eIF5A by small interfering RNA reduced the p53 protein level...
  42. ncbi In situ localization and substrate specificity of earthworm protease-II and protease-III-1 from Eisenia fetida
    Jing Zhao
    State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Graduate School, Baiao Pharmaceuticals Beijing CL, The Chinese Academy of Sciences, Chao Yang District, Beijing, China
    Int J Biol Macromol 40:67-75. 2007
    ..In our experiments, earthworm protease-II (EfP-II) and earthworm protease-III-1 (EfP-III-1) were isolated and purified from Eisenia fetida...
  43. ncbi [A component of earthworm fibrinolytic enzyme having higher thrombolytic activity than total components in vivo]
    Xiao Yu Zhao
    Life Science College of Hebei University, Baoding 071002, China
    Yao Xue Xue Bao 41:1068-73. 2006
    ..To select higher thrombolytic and lower toxic single component of earthworm fibrinolytic enzymes (EFE)...
  44. ncbi Multilocus sequence typing (MLST) of Mycoplasma hyopneumoniae: a diverse pathogen with limited clonality
    Désirée Mayor
    Institute of Veterinary Bacteriology, University of Bern, Bern, Switzerland
    Vet Microbiol 127:63-72. 2008
    ..Out of 12 housekeeping genes chosen and experimentally validated, the 7 genes efp, metG, pgiB, recA, adk, rpoB, and tpiA were finally used to establish the MLST scheme...
  45. doi Preventing lower extremity distal embolization using embolic filter protection: results of the PROTECT registry
    Nicolas W Shammas
    Midwest Cardiovascular Research Foundation, Davenport, IA 52803, USA
    J Endovasc Ther 15:270-6. 2008
    ..the results from a single-center prospective registry (PROTECT) established to evaluate the safety and effectiveness of embolic filter protection (EFP) in reducing distal embolization during percutaneous lower extremity interventions.
  46. doi Indications for extra full projection anatomical cohesive silicone gel implants in cosmetic and reconstructive breast surgery
    Avelina I Mario
    Department of Plastic and Reconstructive Surgery, Addenbrooke s Hospital, Cambridge University Hospitals NHS Trust, Cambridge
    Ann Plast Surg 61:607-12. 2008
    In 2003, a new extra full projection (EFP) anatomic cohesive silicone gel breast implant was introduced onto the European market. This review presents the early experience of a single surgeon with this new implant over a 29-month period...
  47. ncbi Pre- rather than co-application of vigabatrin increases the efficacy of tiagabine in hippocampal slices
    Rüdiger Köhling
    Institute of Physiology, University of Munster, Munster, Germany
    Epilepsia 43:1455-61. 2002
    ..A blockade of the GABA uptake is the main mechanism of action of tiagabine (TGB). Based on this, the two antiepileptic drugs (AEDs) can be speculated to act synergistically so that their combined antiepileptic efficacy is supraadditive...
  48. ncbi Diurnal actions of melatonin on epileptic activity in hippocampal slices of rats
    Ulrich Musshoff
    Institute of Physiology, University of Muenster, Robert Koch Str 27a, 48149 Muenster, Germany
    Life Sci 73:2603-10. 2003
    ..The effect of melatonin (10 nM/l and 1 microM/l) on frequency and amplitude of epileptiform field potentials (EFP) elicited by low Mg(2+) or by bicuculline was tested in the CA1 region of hippocampal slices of rats...
  49. ncbi Pharmacy discounts on generic medicines in France: is there room for further efficiency savings?
    Panos Kanavos
    LSE Health, London School of Economics and Political Science, UK
    Curr Med Res Opin 23:2467-76. 2007
    ..Generic manufacturers and wholesalers may offer discounts, rebates or promotions to pharmacies in order to gain an edge over their competitors, but their true extent is unknown...
  50. pmc Interaction of slow cortical rhythm with somatosensory information processing in urethane-anesthetized rats
    Attila Toth
    Department of Physiology and Neurobiology, Eotvos Lorand University, Budapest, Hungary
    Brain Res 1226:99-110. 2008
    ..silent states. Short-latency (<50 ms) eFP responses consisted of a sequence of deep-negative and deep-positive waves...
  51. doi ISG15 and immune diseases
    Young Joo Jeon
    School of Biological Sciences, Seoul National University, Seoul 151 742, Republic of Korea
    Biochim Biophys Acta 1802:485-96. 2010
    ..g., EFP and HERC5), catalyzes ISG15 conjugation (ISGylation) of a specific protein...
  52. ncbi Antidepressant effects of thyrotropin-releasing hormone analogues using a rodent model of depression
    R L Lloyd
    Department of Psychology, University of Minnesota, 332 Bohannon Hall, 10 University Drive, Duluth, MN 55812 2496, USA
    Pharmacol Biochem Behav 70:15-22. 2001
    ..naturally occurring analogues of thyrotropin-releasing hormone (TRH), pGLU-GLU-PRO-NH2 (EEP) and pGLU-PHE-PRO-NH2 (EFP), were examined using a rodent model of antidepressant efficacy...
  53. ncbi Ab initio structure of the active site of phosphotriesterase
    M Krauss
    Center Advanced Research Biotechnology NIST, Rockville, Maryland 20850, USA
    J Chem Inf Comput Sci 41:8-17. 2001
    ..The GAMESS suite of electronic structure codes has implemented this new methodology, effective fragment potentials (EFP), to make theoretical calculations on structure, spectroscopy, and reactivity tractable for systems involving ..
  54. ncbi Effects of retigabine on rhythmic synchronous activity of human neocortical slices
    H Straub
    Institut fur Physiologie, Universitat Munster, Robert Koch Str 27a, D 48149, Munster, Germany
    Epilepsy Res 44:155-65. 2001
    ..events consisted of spontaneously occurring rhythmic sharp waves, as well as of epileptiform field potentials (EFP) elicited by superfusion with Mg(2+)-free solution without or with addition of 10 micromol/l bicuculline...
  55. ncbi Cell cycle regulatory E3 ubiquitin ligases as anticancer targets
    Todd R Pray
    Rigel Pharmaceuticals, Inc, 240 East Grand Avenue, South San Francisco, California 94080, USA
    Drug Resist Updat 5:249-58. 2002
    ..g. Smurf family, CHFR, and Efp), will be discussed...
  56. ncbi Brief wake episodes modulate sleep-inhibited luteinizing hormone secretion in the early follicular phase
    Janet E Hall
    Reproductive Endocrine Unit, Bartlett Hall Extension 5, Massachusetts General Hospital, 50 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 90:2050-5. 2005
    ..of sleep, sleep stage, and time of day on the dynamics of pulsatile LH secretion in the early follicular phase (EFP) of the menstrual cycle, 11 normal women underwent simultaneous polysomnographic monitoring of sleep and ..
  57. ncbi Physiologic changes in breast magnetic resonance imaging during the menstrual cycle: perfusion imaging, signal enhancement, and influence of the T1 relaxation time of breast tissue
    Jean Paul Delille
    Division of Breast Imaging, Department of Radiology, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02135, USA
    Breast J 11:236-41. 2005
    ..Pre-contrast T1 relaxation times were measured before calculating extraction flow product (EFP) maps using a multicompartmental model...
  58. ncbi Date palm pollen allergoid: characterization of its chemical-physical and immunological properties
    G Mistrello
    Lofarma S p A, Milan, Italy
    Int Arch Allergy Immunol 145:224-30. 2008
    ..The aim of our work was to evaluate IgE cross-reactivity between DP and autochthonous palm (European fan palm, EFP) pollen extracts, to chemically modify DP extract with potassium cyanate in order to obtain an allergoid, and to ..
  59. ncbi Accurate methods for large molecular systems
    Mark S Gordon
    Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA
    J Phys Chem B 113:9646-63. 2009
    ..The effective fragment potential (EFP) method is a sophisticated approach for the prediction of nonbonded and intermolecular interactions...
  60. pmc Negative role of RIG-I serine 8 phosphorylation in the regulation of interferon-beta production
    Estanislao Nistal-Villán
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1124, New York, NY 10029, USA
    J Biol Chem 285:20252-61. 2010
    RIG-I (retinoic acid-inducible gene I) and TRIM25 (tripartite motif protein 25) have emerged as key regulatory factors to induce interferon (IFN)-mediated innate immune responses to limit viral replication...
  61. doi Solvent-induced frequency shifts: configuration interaction singles combined with the effective fragment potential method
    Pooja Arora
    Department of Chemistry and Ames Laboratory, Iowa State University, Ames, Iowa 50011, USA
    J Phys Chem A 114:6742-50. 2010
    ..configuration interaction with single excitations (CIS), has been interfaced with the effective fragment potential (EFP) method to provide an effective and computationally efficient approach for studying the qualitative effects of ..
  62. pmc Noncovalent interactions in extended systems described by the effective fragment potential method: theory and application to nucleobase oligomers
    Debashree Ghosh
    Department of Chemistry, University of Southern California, Los Angeles, California 90089 0482, United States
    J Phys Chem A 114:12739-54. 2010
    The implementation of the effective fragment potential (EFP) method within the Q-CHEM electronic structure package is presented. The EFP method is used to study noncovalent π-π and hydrogen-bonding interactions in DNA strands...
  63. doi Direct simulations of anharmonic infrared spectra using quantum mechanical/effective fragment potential molecular dynamics (QM/EFP-MD): methanol in water
    Manik Kumer Ghosh
    Department of Chemistry and Green Nano Materials Research Center, College of Natural Sciences, Kyungpook National University, Taegu 702 701, South Korea
    J Phys Chem A 116:8965-71. 2012
    ..Here, the applicability of hybrid QM/effective fragment potential (EFP) to the simulations of methanol infrared spectra is investigated in detail...
  64. doi The investigation of degradation and mineralization of high concentrations of formaldehyde in an electro-Fenton process combined with the biodegradation
    Gholamreza Moussavi
    Department of Environmental Health Engineering, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
    J Hazard Mater 237:147-52. 2012
    ..done to evaluate the degradation and mineralization of formaldehyde (≈ 8000 mg/L) in an electro-Fenton process (EFP) in combination with biodegradation...
  65. doi Periodontitis and adverse pregnancy outcomes: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases
    Mariano Sanz
    Facultad de Odontologia, Universidad Complutense de Madrid, Ciudad Universitaria, 28040 Madrid, Spain
    J Clin Periodontol 40:S164-9. 2013
    ..Maternal periodontitis directly and/or indirectly have potential to influence the health of the foetal-maternal unit...
  66. doi Solvent electronic polarization effects on Na(+)-Na(+) and Cl(-)-Cl(-) pair associations in aqueous solution
    Cheol Ho Choi
    Department of Chemistry and Green Nano Materials Research Center, College of Natural Sciences, Kyungpook National University, Taegu 702 701, Korea
    J Phys Chem B 117:9273-9. 2013
    ..aqueous solution was studied by high-level ab initio methods, classical molecular dynamics (MD), QM/TIP5P, and QM/EFP MD (quantum mechanics/effective fragment potential molecular dynamics)...
  67. pmc Methodological approaches for using synchrotron X-ray fluorescence (SXRF) imaging as a tool in ionomics: examples from Arabidopsis thaliana
    Tracy Punshon
    Dartmouth College, Department of Biological Sciences, Life Science Center, 78 College Street, Hanover, NH 03755, USA
    Metallomics 5:1133-45. 2013
    ..will be familiar, in particular the Ionomics Hub and online transcriptomic databases such as the Arabidopsis eFP browser...
  68. doi Efficient and accurate fragmentation methods
    Spencer R Pruitt
    Department of Chemistry, Iowa State University, Ames, Iowa 50011, United States
    Acc Chem Res 47:2786-94. 2014
    ..g., proteins), and to materials that are used as heterogeneous catalysts. The effective fragment potential (EFP) method is a model potential approach that is fully derived from first principles and has no empirically fitted ..
  69. pmc EF-P dependent pauses integrate proximal and distal signals during translation
    Sara Elgamal
    Department of Microbiology and The Center for RNA Biology, Ohio State University, Columbus, Ohio, United States of America
    PLoS Genet 10:e1004553. 2014
    ..reports also demonstrated that levels of most diprolyl-containing proteins are not altered by the deletion of efp. To define the particular sequences that trigger ribosome stalling at diprolyl (PPX) motifs, we used ribosome ..
  70. doi Study on the rheological properties and volatile release of cold-set emulsion-filled protein gels
    Like Mao
    Teagasc Food Research Centre, Moorepark, Fermoy, Co Cork, Ireland
    J Agric Food Chem 62:11420-8. 2014
    Emulsion-filled protein gels (EFP gels) were prepared through a cold-set gelation process, and they were used to deliver volatile compounds...
  71. pmc Structure-function based molecular relationships in Ewing's sarcoma
    Roumiana Todorova
    Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad G Bonchev Strasse, Building 21, 1113 Sofia, Bulgaria
    Biomed Res Int 2015:798426. 2015
    ..The DNA-binding domain, provided by EFP, is bound to the promoter. Rpb4/7 binds RNA, stabilizing the transcription complex...
  72. doi An improved functional assay for rapid detection of marine toxins, saxitoxin and brevetoxin using a portable cardiomyocyte-based potential biosensor
    Qin Wang
    Biosensor National Special Laboratory, Zhejiang University, Hangzhou 310027, PR China Key Laboratory of Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou 310027, PR China Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, PR China
    Biosens Bioelectron 72:10-7. 2015
    ..amplitude, firing rate and 50% of spike potential duration (SPD50) extracted from extracelluar field potential (EFP) signals of the potential biosensor is analyzed to quantitatively evaluate toxicological risk of STX and PbTX-2...
  73. pmc Differential Expression Profile of Chicken Embryo Fibroblast DF-1 Cells Infected with Cell-Adapted Infectious Bursal Disease Virus
    Raymond K Hui
    School of Biological Sciences, The University of Hong Kong, Hong Kong, People s Republic of China
    PLoS ONE 10:e0111771. 2015
    ..of viral RNA genomes and intermediates was presumably enhanced by the elevated levels of IFIH1, DHX58 and TRIM25 genes which possess properties on detecting viral dsRNA...
  74. doi Benefit of ECG-gated rest and stress N-13 cardiac PET imaging for quantification of LVEF in ischemic patients
    Srikara V Peelukhana
    Departments of aMechanical and Materials Engineering bNuclear Medicine cDepartment of Cardiology, Division of Cardiovascular Health and Disease dDepartment of Biomedical Engineering, University of Cincinnati eVeteran Affairs Medical Center, Cincinnati, Ohio, USA
    Nucl Med Commun 36:986-98. 2015
    ..In this study, our aim was to assess the benefit of rest and stress PET ejection fraction (EF) (EFp) in relation to single-photon emission computed tomography (SPECT) EF (EFs) and echocardiography EF (EFe)...
  75. doi A new algorithm to improve assessment of cortical bone geometry in pQCT
    Tomas Cervinka
    Department of Electronics and Communications Engineering, Tampere University of Technology, Korkeakoulunkatu 3, 33720 Tampere, Finland Institute of Bioscience and Medical Technology BioMediTech, Tampere, Finland Electronic address
    Bone 81:721-30. 2015
    ..Using pQCT images of European Forearm Phantom (EFP), and pQCT and HR-pQCT images of the distal tibia from 15 cadavers, we compared the results from the OBS algorithm ..
  76. doi Derivation and Implementation of the Gradient of the R(-7) Dispersion Interaction in the Effective Fragment Potential Method
    Emilie B Guidez
    Department of Chemistry, Iowa State University, Ames, Iowa 50011, United States
    J Phys Chem A 120:639-47. 2016
    ..Because the effective fragment potential (EFP) method contains no empirically fitted parameters, the EFP method provides a useful vehicle for examining the ..
  77. pmc The RNA- and TRIM25-Binding Domains of Influenza Virus NS1 Protein Are Essential for Suppression of NLRP3 Inflammasome-Mediated Interleukin-1β Secretion
    Miyu Moriyama
    Division of Viral Infection, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo, Japan Department of Life Science and Medical Bioscience, Waseda University, Shinjuku ku, Tokyo, Japan Department of Pathology, National Institute of Infectious Diseases, Shinjukuu ku, Tokyo, Japan
    J Virol 90:4105-14. 2016
    ..The NS1 RNA-binding domain (basic residues 38 and 41) and TRIM25-binding domain (acidic residues 96 and 97) were required for suppression of NLRP3 inflammasome-mediated IL-1β ..
  78. doi Solvatochromic Shifts in UV-Vis Absorption Spectra: The Challenging Case of 4-Nitropyridine N-Oxide
    Simon Budzák
    CEISAM, UMR CNRS 6230, BP 92208, 2 rue de la Houssiniere, 44322 Nantes, Cedex 3, France
    J Chem Theory Comput 12:1919-29. 2016
    ..several flavors of the polarizable continuum model, as well as dynamics using an effective fragment potential (EFP) description of the solvent molecules...
  79. doi Dissemination of veterinary antibiotics and corresponding resistance genes from a concentrated swine feedlot along the waste treatment paths
    Jian Wang
    Key Laboratory of Drinking Water Science and Technology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, 18 Shuang Qing Road, Beijing 100085, China University of Chinese Academy of Sciences, 19A Yu Quan Road, Beijing 100049, China
    Environ Int 92:317-23. 2016
    ..Fourteen tetracycline resistance genes (TRGs) encoding ribosomal protection proteins (RPP), efflux proteins (EFP) and enzymatic inactivation proteins, three sulfonamide resistance genes (SRGs), and two integrase genes were ..
  80. pmc Dynamic modulation of expression of lentiviral restriction factors in primary CD4+ T cells following SIV infection
    Andrew R Rahmberg
    Virology Program, Harvard University, Graduate School of Arts and Sciences, Division of Medical Science, Boston MA 02115
    J Virol . 2017
    ..T cells exhibited significantly lower expression of multiple restriction factors, including APOBEC3G, MX2, and TRIM25, which may contribute to the exquisite susceptibility of these cells to SIV infection...
  81. ncbi [The research of thrombolytic and hemolysis effect from Eupolyphage fibrinolyric protein and its inhibitory effect on S180 ascites tumor of mice]
    Zi Wei Li
    Faculty of light and Chemical, Guangdong University of Technology, Guangzhou 510006, China
    Zhong Yao Cai 33:859-63. 2010
    Eupolyphage fibrinolyric protein (EFP) was isolated and purified from Eupolyphage sineses, and its thrombolytic effect, hemolysis effect and inhibitory effect on S180 ascites tumor were investigated.
  82. doi C-H bond activation of methane in aqueous solution: a hybrid quantum mechanical/effective fragment potential study
    Júlio C S Da Silva
    Laboratório de Química Computacional e Modelagem Molecular LQC MM, Departamento de Quimica, ICEx, Universidade Federal de Minas Gerais, Campus Universitário Pampulha, 31270 901 Belo Horizonte, Minas Gerias, Brazil
    J Comput Chem 32:3383-92. 2011
    ..methane catalyzed by the complex [PtCl(4)](2-), using the hybrid quantum mechanical/effective fragment potential (EFP) approach...
  83. doi Proteomic analysis of ubiquitination-associated proteins in a cisplatin-resistant human lung adenocarcinoma cell line
    Xia Qin
    The First Affiliated Hospital of Chongqing Medical University, Chongqing, P R China
    Int J Mol Med 29:791-800. 2012
    ..scanning microscopy indicated that the expression levels of the E3 ubiquitin ligases RNF6, LRSAM1 and TRIM25 in A549 cells were significantly lower than those in the A549/CDDP cell line...
  84. ncbi Methylseleninic acid (MSA) inhibits 17β-estradiol-induced cell growth in breast cancer T47D cells via enhancement of the antioxidative thioredoxin/ thioredoxin reductase system
    Tomofumi Okuno
    Department of Public Health and Preventive Pharmacology, Setsunan University, Nagaotogecho, Hirakata, Osaka, Japan
    Biomed Res 33:201-10. 2012
    ..mRNA levels and subsequent protein levels; further decreasing expression of estrogen-responsive finger protein (Efp) which is a target gene product of ERα and promotes G2/M progression of the cell cycle...
  85. doi Agaricus bisporus fucogalactan: structural characterization and pharmacological approaches
    Andrea C Ruthes
    Departamento de Bioquimica e Biologia Molecular, Universidade Federal do Parana, CP 19046, CEP 81531 980, Curitiba, PR, Brazil
    Carbohydr Polym 92:184-91. 2013
    The fucogalactan from Agaricus bisporus (EFP-Ab) obtained on aqueous extraction followed by purification had M(w) 37...
  86. doi Diabetes and periodontal diseases: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases
    Iain L C Chapple
    Periodontal Research Group and MRC Centre for Immune Regulation, University of Birmingham School of Dentistry, Birmingham, UK
    J Clin Periodontol 40:S106-12. 2013
    ....
  87. ncbi Epileptogenic effect of cyclosporine in guinea-pig hippocampal slices
    A Gorji
    Institut fur Physiologie, Universitat Munster, Robert Koch Strasse 27a, 48149, Munster, Germany
    Neuroscience 115:993-7. 2002
    ..fluid of the patients suffering from seizure attacks was ineffective to induce epileptiform field potentials (EFP) in in vitro brain-slice preparation...
  88. ncbi Efp as a new molecular target for breast cancer therapy
    Kuniko Horie
    Research Center for Genomic Medicine, Saitama Medical School, Hidaka shi, Saitama, Japan
    Anticancer Drugs 14:1-2. 2003
  89. ncbi Therapeutic anti-cancer targets upstream of the proteasome
    Grzegorz Nalepa
    Program in Cellular and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Cancer Treat Rev 29:49-57. 2003
    ..F-box proteins, such as Skp2, and the inhibition of the ubiquitin ligases such as the SCF family, Mdm2, and Efp. A general pathway under investigation is the cullin neddylation and deneddylation system, with promising enzymatic ..
  90. ncbi [Effects of epimedium total flavonoids phytosomes on preventing and treating bone-loss of ovariectomized rats]
    Yong nan Jiang
    Guangzhou Railway Central Hospital, Guangzhou 510080, Guangdong, China
    Zhongguo Zhong Yao Za Zhi 27:221-4. 2002
    ..To observe the effects of Epimedium total Flavonoids Phytosomes on preventing and treating bone-loss of the castrate osteoporosis rat model...
  91. ncbi Muscle strength testing: evaluation of tests of explosive force production
    Dragan M Mirkov
    Department of Biophysics, School of Medicine, Belgrade University, Dr Subotica 8, 11 000, Belgrade, Yugoslavia
    Eur J Appl Physiol 91:147-54. 2004
    The purpose of the study was to evaluate four tests of explosive force production (EFP)...
  92. ncbi The interferon-inducible ubiquitin-protein isopeptide ligase (E3) EFP also functions as an ISG15 E3 ligase
    Weiguo Zou
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Biol Chem 281:3989-94. 2006
    ..Here, we report the identification of the ubiquitin-protein isopeptide ligase (E3) EFP (estrogen-responsive finger protein) as the ISG15 E3 ligase for 14-3-3sigma protein...
  93. pmc Power Doppler ultrasound assessment of follicular vascularity in the early follicular phase and its relationship with outcome of in vitro fertilization
    S M Shrestha
    School of Women s and Children s Health, University of New South Wales, Sydney, New South Wales, Australia
    J Assist Reprod Genet 23:161-9. 2006
    To determine whether ovarian perifollicular blood flow (PFBF) in the early follicular phase (EFP) was associated with treatment outcome.
  94. doi Solvent-induced shifts in electronic spectra of uracil
    Albert DeFusco
    Department of Chemistry and Ames Laboratory, Iowa State University, Ames, Iowa 50011, United States
    J Phys Chem A 115:4574-82. 2011
    ..Implementation of the effective fragment potential (EFP) solvent method with CASSCF and MCQDPT enables the prediction of highly accurate solvated spectra, along with a ..
  95. ncbi The oxidation of Al atoms embedded in water clusters: a dynamical study of the relay (Grotthuss-like) mechanism
    S Alvarez-Barcia
    Departamento de Química Física, Facultad de Química, Universidade de Vigo, Vigo Pontevedra, Spain
    J Chem Phys 134:244305. 2011
    ..theory (DFT) theory and the other m = {52, 56} waters have been represented by an effective fragment potential (EFP)...
  96. doi Interionic hydration structures of NaCl in aqueous solution: a combined study of quantum mechanical cluster calculations and QM/EFP-MD simulations
    Manik K Ghosh
    Department of Chemistry and Green Nano Materials Research Center, College of Natural Sciences, Kyungpook National University, Taegu 702 701, Korea
    J Phys Chem B 117:289-95. 2013
    ..on NaCl(H(2)O)(n) (n = 1-6) clusters and quantum mechanical/effective fragment potential-molecular dynamics (QM/EFP-MD) simulations for NaCl in 292 EFP waters...
  97. pmc Tripartite motif ligases catalyze polyubiquitin chain formation through a cooperative allosteric mechanism
    Frederick C Streich
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Biol Chem 288:8209-21. 2013
    ..Initial rate studies under biochemically defined conditions show that TRIM32 and TRIM25 are specific for the Ubc5 family of E2-conjugating proteins and, along with TRIM5α, exhibit cooperative kinetics ..
  98. ncbi Estrogen receptor activation at serine 305 is sufficient to upregulate cyclin D1 in breast cancer cells
    Seetharaman Balasenthil
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    FEBS Lett 567:243-7. 2004
    ..e., cyclin D1 and zinc finger protein 147 (estrogen-responsive finger protein), while there was no significant change in the expression of ..
  99. ncbi Estrogen receptors and their downstream targets in cancer
    Kazuhiro Ikeda
    Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical School, 1397 1 Yamane, Hidaka shi, Saitama 350 1241, USA
    Arch Histol Cytol 67:435-42. 2004
    ..Among these genes, the estrogen-responsive finger protein (Efp) was found to be highly expressed in breast cancer...
  100. doi Electrocortical indices of selective attention predict adolescent executive functioning
    Christine L Lackner
    Psychology Department, Brock University, St Catharines, ON, Canada
    Biol Psychol 93:325-33. 2013
    ..reports on the Behavior Rating Inventory of Executive Function (BRIEF) revealed that an early frontal positivity (EFP) elicited by to-be-ignored/unattended tones was larger in those with poorer executive functions, driven by scores ..
  101. pmc Type I IFN triggers RIG-I/TLR3/NLRP3-dependent inflammasome activation in influenza A virus infected cells
    Julien Pothlichet
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    PLoS Pathog 9:e1003256. 2013
    ..RIG-I had the strongest effect through a MAVS/TRIM25/Riplet-dependent type I IFN signaling pathway upstream of TLR3 and NLRP3...

Research Grants20

  1. Host-pathogen competition in IFN mediated antiviral defense
    Jae U Jung; Fiscal Year: 2013
    ..Project 1 utilizes cell biological and immunological approaches to study RIG-I and TRIM25 mediated immune surveillance against virus;Project 2 focuses on the structural basis of RIG-I and MDA-5 mediated ..
  2. Michaela Ulrike Gack; Fiscal Year: 2016
    ..RIG-I undergoes robust Lys 63- linked ubiquitination induced by TRIM25, enabling RIG-I to interact with the CARD-containing adaptor MAVS, and thereby triggering anti-viral signal ..
  3. RIG-I and TRIM25 mediated immune surveillance against virus
    Jae U Jung; Fiscal Year: 2010
    ..Subsequently, RIG-I undergoes a robust ubiquitination induced by the TRIM25 E3 ligase, enabling RIG-I to interact with the downstream CARD-containing mitochondrial anti-viral signaling (MAVS)..
  4. ATP-Ubiquitin Dependent Proteolysis
    Arthur L Haas; Fiscal Year: 2011
    ..Kinetic studies will quantify the ability of UbcH7 (ubiquitin specific) and UbcH8 (ISG15 specific) to support Epf/Trim25 ligase in regulating levels of the anti-mitotic 14-3-3C protein implicated in breast and prostate cancers...
  5. Intrahepatic IRF-3 and NF-kB Signaling and Interferon Responses in Hepatitis C
    Stanley M Lemon; Fiscal Year: 2010
    ..and proinflammatory cytokines (including the PAMP receptors, RIG-I and TLR3, as well as 2'5'OAS, PKR, TRIM25, RNF125, and NLRX1), and determine if their expression is altered by HCV infection...
  6. Quantum Computation with Effective Fragment Potential
    Jing Kong; Fiscal Year: 2010
    ..by applicant): This Phase II proposal seeks support for completing implementation of effective fragment potential (EFP) method [J. Phys. Chem. A, v.105 p.293 (2001)] in the Q-Chem electronic structure program...
  7. Quantum Computation with Effective Fragment Potential
    Jing Kong; Fiscal Year: 2006
    ..provided by applicant): This Phase I proposal seeks support for implementing effective fragment potential (EFP) method [J. Phys. Chem. A, v.105 p.293 (2001)] in the Q-Chem electronic structure program...
  8. High Throughput Screen for Inhibitors of Influenza NS1 Protein Function
    Daniel Engel; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  9. CHROMATIN TARGETS FOR CANCER THERAPY
    Daniel Engel; Fiscal Year: 2002
    ..Lead compounds will be tested further in mammalian cell culture systems to examine their potential as therapeutic agents, and their specific effects on mammalian chromatin dynamics. ..
  10. PHYSIOLOGY OF ESTROGEN'S MOOD EFFECT IN MENOPAUSAL WOMEN
    Hadine Joffe; Fiscal Year: 2007
    ..Such training will lay the foundation for a career of clinical investigation into the physiology of perimenopausal depression and the impact of hot flushes on sleep, mood, and quality-of-life. ..
  11. Novel Tool Compounds for Chromatin Research
    Daniel Engel; Fiscal Year: 2004
    ..These two areas will be the main thrust of the future development of this project. ..
  12. Development of Yeast-Based Assays for anti-influenza drug discovery
    Daniel Engel; Fiscal Year: 2006
    ..This system will be used to establish microtiter plate assays and robotics screening. [unreadable] [unreadable] [unreadable]..
  13. ADENOVIRUS E1A PROTEIN AND THE SWI/SNF COMPLEX
    Daniel Engel; Fiscal Year: 2005
    ..The yeast proteins that interact with E1A will be identified and their influence on E1A activity will be determined. Similar studies will then be conducted in mammalian cells using the information gained from the yeast system. ..
  14. NEUROENDOCRINE CONTROL OF REPRODUCTION IN THE FEMALE
    Janet Hall; Fiscal Year: 2008
    ..Taken together, these projects provide a strong program for training in clinical investigation that utilizes a variety of methodologies to address critical hypotheses in reproductive biology. ..
  15. Discovery of B. pseudomallei Therapeutics for Biodefense
    Donald Moir; Fiscal Year: 2008
    ..pseudomallei targets. In Phase III, a potent, safe, orally active B. pseudomallei inhibitor will be advanced into IND enabling toxicology and safety pharmacology studies and file an IND. [unreadable] [unreadable] [unreadable]..
  16. Gender & orthostatic intolerance: mechanisms and therapy
    Qi Fu; Fiscal Year: 2008
    ..The combination of advanced training in patient-oriented research and in-depth study of an important clinical problem will prepare me well for a career as an independent investigator. ..
  17. Type III Secretion Inhibitors for Anti-Infective Therapy
    Donald Moir; Fiscal Year: 2007
    ..aeruginosa TTSS; (3) Screen a diverse compound library to identify and validate TTSS inhibitors; and (4) Prioritize validated screening hits for in vitro potency, mechanism, spectrum, and selectivity. [unreadable] [unreadable]..
  18. FSH, Estradiol and Inhibin in Female Reproduction
    Janet Hall; Fiscal Year: 2006
    ..This information is ultimately required for the design of therapeutic options for patients with reproductive disorders including infertility. ..
  19. DNA helicase and primase inhibitors for biodefense
    Donald Moir; Fiscal Year: 2006
    ..Finally, compounds will be tested for lack of toxicity to mammalian cells in culture, and lack of activity against eukaryotic polymerase alpha and helicase, resulting in a collection of validated hits. ..
  20. Sensing Biowarfare Agents by Surface Enhanced Raman
    Donald Moir; Fiscal Year: 2005
    ....