TSPY

Summary

Gene Symbol: TSPY
Description: testis specific protein, Y-linked 1
Alias: CT78, DYS14, TSPY, pJA923, testis-specific Y-encoded protein 1, cancer/testis antigen 78
Species: human

Top Publications

  1. ncbi Testis-specific protein, Y-encoded (TSPY) expression in testicular tissues
    F Schnieders
    Institut fur Humangenetik, Medizinische Hochschule Hannover, Germany
    Hum Mol Genet 5:1801-7. 1996
  2. ncbi Structure and function of TSPY, the Y-chromosome gene coding for the "testis-specific protein"
    T Vogel
    Institute of Human Genetics, Medizinische Hochschule Hannover, Germany
    Cytogenet Cell Genet 80:209-13. 1998
  3. pmc Gonadoblastoma, testicular and prostate cancers, and the TSPY gene
    Y F Lau
    Division of Cell and Developmental Genetics, Department of Medicine, VAMC 111C5, University of California, San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    Am J Hum Genet 64:921-7. 1999
  4. ncbi Expression analysis of thirty one Y chromosome genes in human prostate cancer
    Y F Lau
    Division of Cell and Developmental Genetics, Department of Medicine, VA Medical Center, 111C5, University of California, San Francisco, San Francisco, California 94121, USA
    Mol Carcinog 27:308-21. 2000
  5. ncbi Expression of a candidate gene for the gonadoblastoma locus in gonadoblastoma and testicular seminoma
    Y Lau
    Department of Medicine, VA Medical Center, University of California, San Francisco CA, USA
    Cytogenet Cell Genet 91:160-4. 2000
  6. ncbi Expression, alternative splicing and haplotype analysis of transcribed testis specific protein (TSPY) genes
    Roswitha Krick
    Institute of Human Genetics, Johann Wolfgang Goethe University Hospital, Theodor Stern Kai 7 Haus 9, D 60590, Frankfurt am Main, Germany
    Gene 302:11-9. 2003
  7. ncbi Expression pattern of a gonadoblastoma candidate gene suggests a role of the Y chromosome in prostate cancer
    Y F C Lau
    Department of Medicine, VA Medical Center, University of California, San Francisco, San Francisco, CA 94121, USA
    Cytogenet Genome Res 101:250-60. 2003
  8. ncbi A Cre gene directed by a human TSPY promoter is specific for germ cells and neurons
    Tatsuo Kido
    Division of Cell and Developmental Genetics, Department of Medicine, VA Medical Center, University of California, San Francisco, San Francisco, California 94121, USA
    Genesis 42:263-75. 2005
  9. ncbi CK2-dependent C-terminal phosphorylation at T300 directs the nuclear transport of TSPY protein
    Roswitha Krick
    Institute of Human Genetics, Johann Wolfgang Goethe University Hospital, Frankfurt am Main, Germany
    Biochem Biophys Res Commun 341:343-50. 2006
  10. pmc TSPY potentiates cell proliferation and tumorigenesis by promoting cell cycle progression in HeLa and NIH3T3 cells
    Shane W Oram
    Department of Medicine, VA Medical Center, University of California, San Francisco, USA
    BMC Cancer 6:154. 2006

Research Grants

  1. Yun Fai Chris Lau; Fiscal Year: 2014
  2. FUNCTIONS OF SRY AND SRY INTERACTIVE PROTEIN GENES
    Yun Fai Chris Lau; Fiscal Year: 2004

Detail Information

Publications145 found, 100 shown here

  1. ncbi Testis-specific protein, Y-encoded (TSPY) expression in testicular tissues
    F Schnieders
    Institut fur Humangenetik, Medizinische Hochschule Hannover, Germany
    Hum Mol Genet 5:1801-7. 1996
    b>TSPY, the 'testis-specific protein, Y-encoded', is the product of a tandem gene cluster on human proximal Yp...
  2. ncbi Structure and function of TSPY, the Y-chromosome gene coding for the "testis-specific protein"
    T Vogel
    Institute of Human Genetics, Medizinische Hochschule Hannover, Germany
    Cytogenet Cell Genet 80:209-13. 1998
    The TSPY genes are arranged in clusters on the Y chromosome of many mammalian species. TSPY is believed to function in early spermatogenesis and is a candidate for GBY, the putative gonadoblastoma-inducing gene on the Y...
  3. pmc Gonadoblastoma, testicular and prostate cancers, and the TSPY gene
    Y F Lau
    Division of Cell and Developmental Genetics, Department of Medicine, VAMC 111C5, University of California, San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    Am J Hum Genet 64:921-7. 1999
  4. ncbi Expression analysis of thirty one Y chromosome genes in human prostate cancer
    Y F Lau
    Division of Cell and Developmental Genetics, Department of Medicine, VA Medical Center, 111C5, University of California, San Francisco, San Francisco, California 94121, USA
    Mol Carcinog 27:308-21. 2000
    ..g., ZFY, PRKY, DFFRY, TB4Y, EIF1AY, and UTY) and Y-specific genes (e.g., SRY, TSPY, PRY, and XKRY)...
  5. ncbi Expression of a candidate gene for the gonadoblastoma locus in gonadoblastoma and testicular seminoma
    Y Lau
    Department of Medicine, VA Medical Center, University of California, San Francisco CA, USA
    Cytogenet Cell Genet 91:160-4. 2000
    ..To evaluate the candidacy of one of these five genes, testis-specific protein Y-encoded (TSPY), as the gene for GBY, expression patterns of TSPY in four gonadoblastoma from three patients were analyzed by ..
  6. ncbi Expression, alternative splicing and haplotype analysis of transcribed testis specific protein (TSPY) genes
    Roswitha Krick
    Institute of Human Genetics, Johann Wolfgang Goethe University Hospital, Theodor Stern Kai 7 Haus 9, D 60590, Frankfurt am Main, Germany
    Gene 302:11-9. 2003
    Testis specific protein (TSPY) is a human Y-chromosome derived gene with numerous functional and non-functional copies...
  7. ncbi Expression pattern of a gonadoblastoma candidate gene suggests a role of the Y chromosome in prostate cancer
    Y F C Lau
    Department of Medicine, VA Medical Center, University of California, San Francisco, San Francisco, CA 94121, USA
    Cytogenet Genome Res 101:250-60. 2003
    ..Recently a candidate gene, the testis-specific protein Y-encoded (TSPY) that resides on the GBY critical region, has been demonstrated to express preferentially in tumor cells in ..
  8. ncbi A Cre gene directed by a human TSPY promoter is specific for germ cells and neurons
    Tatsuo Kido
    Division of Cell and Developmental Genetics, Department of Medicine, VA Medical Center, University of California, San Francisco, San Francisco, California 94121, USA
    Genesis 42:263-75. 2005
    The testis-specific protein Y-encoded (TSPY) gene is a candidate for the gonadoblastoma locus on the Y chromosome and is expressed in normal testicular germ cells and gonadoblastoma cells of XY sex-reversed females...
  9. ncbi CK2-dependent C-terminal phosphorylation at T300 directs the nuclear transport of TSPY protein
    Roswitha Krick
    Institute of Human Genetics, Johann Wolfgang Goethe University Hospital, Frankfurt am Main, Germany
    Biochem Biophys Res Commun 341:343-50. 2006
    b>TSPY (testis-specific protein, Y-encoded) is a member of the greater SET/NAP family of molecules with various functions, e.g...
  10. pmc TSPY potentiates cell proliferation and tumorigenesis by promoting cell cycle progression in HeLa and NIH3T3 cells
    Shane W Oram
    Department of Medicine, VA Medical Center, University of California, San Francisco, USA
    BMC Cancer 6:154. 2006
    b>TSPY is a repeated gene mapped to the critical region harboring the gonadoblastoma locus on the Y chromosome (GBY), the only oncogenic locus on this male-specific chromosome...
  11. doi The human Y-encoded testis-specific protein interacts functionally with eukaryotic translation elongation factor eEF1A, a putative oncoprotein
    Tatsuo Kido
    Division of Cell and Developmental Genetics, Department of Medicine, Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
    Int J Cancer 123:1573-85. 2008
    Testis-specific protein Y-encoded (TSPY) is the putative gene for the gonadoblastoma locus on the Y chromosome...
  12. doi The chromosome Y-linked testis-specific protein locus TSPY1 is characteristically present in gonadoblastoma
    Johann D Hertel
    Lauren V Ackerman Laboratory of Surgical Pathology, Department of Pathology and Immunology, Washington University Medical Center, St Louis, MO 63110 1093, USA
    Hum Pathol 41:1544-9. 2010
    ....
  13. doi Role of the Y-located putative gonadoblastoma gene in human spermatogenesis
    Yun Fai Chris Lau
    Division of Cell and Developmental Genetics, Department of Medicine, Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
    Syst Biol Reprod Med 57:27-34. 2011
    ..The testis-specific protein Y-linked (TSPY) repeat gene has recently been demonstrated to be the putative gene for GBY, based on its location on the GBY ..
  14. doi Sequence recombination in exon 1 of the TSPY gene in men with impaired fertility
    Veronika Svacinova
    Department of Medical Genetics and Foetal Medicine, Palacky University Olomouc and University Hospital Olomouc, Czech Republic
    Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 155:287-98. 2011
    The aim of this study was to evaluate TSPY (testis specific protein on the Y chromosome) gene and 5'UTR (UnTranslated Region) polymorphisms in men with impaired fertility compared to fertile controls.
  15. ncbi Identification of germ cells at risk for neoplastic transformation in gonadoblastoma: an immunohistochemical study for OCT3/4 and TSPY
    Anne Marie F Kersemaekers
    Department of Pathology, Josephine Nefkens Institute, Daniel de Hoed Cancer Center, Erasmus MC University Medical Center Rotterdam, The Netherlands
    Hum Pathol 36:512-21. 2005
    ..In this process, part of the Y chromosome (GBY region) is involved, for which TSPY is a candidate gene...
  16. ncbi Molecular isolation and characterization of an expressed gene from the human Y chromosome
    J S Zhang
    Division of Cell and Developmental Genetics, VA Medical Center, University of California, San Francisco 94121
    Hum Mol Genet 1:717-26. 1992
    ..high (97%) identity at the DNA level to a previously described Y-specific gene, testis specific protein Y-encoded (TSPY) gene, suggesting the possibility that these two genes are related, if not identical...
  17. ncbi Cloning and sequence analysis of a human Y-chromosome-derived, testicular cDNA, TSPY
    J Arnemann
    National Institute for Medical Research, Laboratory of Eukaryotic Molecular Genetics, London, United Kingdom
    Genomics 11:108-14. 1991
    ..Using this probe we have now isolated the cDNA sequence pJA923 from a human testis cDNA library...
  18. ncbi Characterization of a new TSPY gene family member in Yq (TSPYq1)
    A Ratti
    Istituto di Clinica Neurologica, Universita di Milano, Ospedale Policlinico IRCCS, Chieti Italy
    Cytogenet Cell Genet 88:159-62. 2000
    ..TSPYq1, a member of the TSPY multi-copy gene family, was isolated and characterized from a yOX17 cosmid subclone...
  19. ncbi TSPY variants in six loci on the human Y chromosome
    F Dechend
    Institut fur Humangenetik, Medizinische Hochschule, Hannover, Germany
    Cytogenet Cell Genet 91:67-71. 2000
    We have studied the structure, organization, and evolution of the human TSPY gene family by mapping three sequence variants identified through RT-PCR analysis onto genomic clones derived from two different YAC contigs...
  20. ncbi Detection and incidence of cryptic Y chromosome sequences in Turner syndrome patients
    P C Patsalis
    Department of Cytogenetics, The Cyprus Institute of Neurology and Genetics, Nicosia
    Clin Genet 53:249-57. 1998
    ..by Southern blot analysis of three genes the sex determining region Y (SRY), testis specific protein Y encoded (TSPY) and RNA binding motif protein (RBM) (previously designated as YRRM) and nine additional STSs spanning all seven ..
  21. doi SRY gene increases the risk of developing gonadoblastoma and/or nontumoral gonadal lesions in Turner syndrome
    Bianca Bianco
    Division of Endocrinology, Department of Medicine, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    Int J Gynecol Pathol 28:197-202. 2009
    ..Genomic DNA was extracted from peripheral blood and genes SRY and TSPY and DYZ3 repeat of the Y chromosome were amplified by polymerase chain reaction...
  22. ncbi Supernumerary marker chromosomes (SMCs) in Turner syndrome are mostly derived from the Y chromosome
    P C Patsalis
    Department of Cytogenetics, Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus
    Clin Genet 51:184-90. 1997
    ..The Sex determining Region Y (SRY), Testis Specific Protein Y-encoded (TSPY) and Y-chromosome RNA Recognition Motif (YRRM) genes, which map at Yp11.31, Yp11.1-11.2 and Yp11.2/Yq11.21-11...
  23. ncbi Cercopithecine Y-chromosome data provide a test of competing morphological evolutionary hypotheses
    Anthony J Tosi
    Department of Anthropology, Molecular Anthropology Laboratory, New York University, New York, NY 10003, USA
    Mol Phylogenet Evol 27:510-21. 2003
    ..A total of 44 individuals were surveyed for approximately 2.2 kb of the testis-specific protein, Y-chromosome (TSPY). The TSPY sequences were subjected to parsimony analyses in PAUP 4...
  24. doi Gonadoblastoma locus and the TSPY gene on the human Y chromosome
    Yun Fai Chris Lau
    Division of Cell and Developmental Genetics, Department of Medicine, VA Medical Center, University of California, San Francisco, California 94121, USA
    Birth Defects Res C Embryo Today 87:114-22. 2009
    ..Recent studies establish the testis-specific protein Y-encoded (TSPY) gene to be the putative gene for GBY...
  25. ncbi Tumor risk in disorders of sex development (DSD)
    Leendert H J Looijenga
    Department of Pathology, Erasmus MC University Medical Center Rotterdam, Daniel den Hoed Cancer Center, Josephine Nefkens Institute, Building Be, Room 430b, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Best Pract Res Clin Endocrinol Metab 21:480-95. 2007
    ..region) is a prerequisite for malignant transformation, for which the testis-specific protein on the Y chromosome (TSPY) is a likely candidate gene...
  26. doi New insights into type II germ cell tumor pathogenesis based on studies of patients with various forms of disorders of sex development (DSD)
    Remko Hersmus
    Department of Pathology, Erasmus MC University Medical Center Rotterdam, Daniel den Hoed Cancer Center, Josephine Nefkens Institute, Rotterdam, The Netherlands
    Mol Cell Endocrinol 291:1-10. 2008
    ..II GCT formation is the presence of a specific part of the Y chromosome (referred to as the GBY region), with the TSPY gene being the most likely candidate...
  27. doi Macroscopic sertoli cell nodule: a study of 6 cases that presented as testicular masses
    Bethany D Vallangeon
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Clarian Pathology Laboratory, Indianapolis, IN, USA
    Am J Surg Pathol 34:1874-80. 2010
    ..An antibody for testis-specific protein, Y-encoded (TSPY), stained the spermatogonia (2 of 2 cases), whereas OCT 3/4 was negative in all the cases (5 of 5 cases)...
  28. ncbi Histologic analysis of gonadal tissue in patients with Ullrich-Turner syndrome and derivative Y chromosomes
    L C Horn
    Institute of Pathology, Division of Perinatal and Gynecologic Pathology, University of Leipzig, Liebigstrasse 26, Leipzig D 04103, Germany
    Pediatr Dev Pathol 8:197-203. 2005
    ..Molecular analysis represented loci PABY, SRY, ZFY, TSPY, DYZ3, DYZ1 DXYS, 19Y, DYS-273, DYS-148, DYS218, DYS224, and DYZ1...
  29. ncbi Testis-specific protein Y-encoded gene is expressed in early and late stages of gonadoblastoma and testicular carcinoma in situ
    Yunmin Li
    Department of Medicine, VA Medical Center, University of California, San Francisco, CA 94121, USA
    Urol Oncol 25:141-6. 2007
    The testis-specific protein Y-encoded gene (TSPY) is a tandem repeat gene located at the critical region for the gonadoblastoma locus on Y chromosome that predisposes the dysgenetic gonads of intersex individuals to oncogenesis...
  30. ncbi TSPY, the candidate gonadoblastoma gene on the human Y chromosome, has a widely expressed homologue on the X - implications for Y chromosome evolution
    Margaret L Delbridge
    INSERM U 491 Faculté de Médecine, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
    Chromosome Res 12:345-56. 2004
    b>TSPY, a candidate gene for a factor that promotes gonadoblastoma formation (GBY), is a testis-specific multicopy gene family in the male-specific region of the human Y (MSY) chromosome...
  31. ncbi Sex chromosome phylogenetics indicate a single transition to terrestriality in the guenons (tribe Cercopithecini)
    Anthony J Tosi
    Department of Anthropology, New York University, NY 10003, USA
    J Hum Evol 46:223-37. 2004
    ..We surveyed 20 guenons (tribe Cercopithecini) and 4 outgroup taxa for two Y-chromosomal genes, TSPY ( approximately 2240 bp) and SRY ( approximately 780 bp), and one X-chromosomal intergenic region ( approximately ..
  32. ncbi Fetal microchimerism in Hashimoto's thyroiditis: a quantitative approach
    Michael Klintschar
    Institute of Legal Medicine, University Halle Wittenberg, Halle Saale, Germany
    Eur J Endocrinol 154:237-41. 2006
    ..The goal of the study was to reliably estimate the number of fetal engrafted cells and to further investigate factors influencing the development of MCH...
  33. pmc Male microchimerism in women with systemic sclerosis and healthy women who have never given birth to a son
    N C Lambert
    INSERM U639, Faculté de médecine La Timone, 13005 Marseille, France
    Ann Rheum Dis 64:845-8. 2005
    ..Male DNA or cells are often used to measure microchimerism in a woman. In studies of autoimmune diseases male microchimerism is most often attributed to the previous birth of a son...
  34. doi Fetal microchimerism in breast from women with and without breast cancer
    Vijayakrishna K Gadi
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Breast Cancer Res Treat 121:241-4. 2010
    ..DNA, presumably from a prior male fetus, was determined with a quantitative PCR assay for the Y chromosome gene, DYS14. Proportions of tissues harboring fetal microchimerism were compared...
  35. ncbi [Correlation of free fetal DNA with beta-human chorionin gonadotropin in circulation in pregnant women with high risk of Down's syndrome]
    Jin Lai Meng
    Department of Obstetrics and Gynecology, Provincial Hospital affiliated to Shandong University, Jinan 250021, China
    Zhonghua Fu Chan Ke Za Zhi 44:661-4. 2009
    ..To investigate significance and correlation of free fetal DNA (fDNA) and beta-human chorionic gonadotropin (beta-hCG) in circulation in pregnant women with high-risk of Down's syndrome (DS)...
  36. ncbi Male microchimerism in healthy women and women with scleroderma: cells or circulating DNA? A quantitative answer
    Nathalie C Lambert
    Fred Hutchinson Cancer Research Center the University of Washington Medical Center and the Virginia Mason Medical Center, Seattle, WA 98109 1024, USA
    Blood 100:2845-51. 2002
    ..we developed a real-time quantitative polymerase chain reaction (PCR) assay for the Y-chromosome-specific sequence DYS14, and tested 114 women in peripheral blood mononuclear cells (PBMCs) and/or plasma...
  37. ncbi Correlation of maternal plasma total cell-free DNA and fetal DNA levels with short term outcome of first-trimester vaginal bleeding
    Aihua Yin
    Department of Anatomy, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, Guangdong 510089, People s Republic of China
    Hum Reprod 22:1736-43. 2007
    ..The aim of this study was to determine whether maternal plasma fetal DNA and total DNA levels could be used to predict spontaneous abortion...
  38. ncbi Molecular characterization of a polymorphic 3-Mb deletion at chromosome Yp11.2 containing the AMELY locus in Singapore and Malaysia populations
    Rita Y Y Yong
    Defence Medical and Environmental Research Institute, DSO National Laboratories, 27 Medical Drive 12 00, Singapore, Singapore
    Hum Genet 122:237-49. 2007
    ..7-Mb located at the Yp11.2 region. Both breakpoints were located in TSPY repeat arrays, suggesting a non-allelic homologous recombination (NAHR) mechanism of deletion...
  39. doi A new cause of male infertility after cisplatin exposure: the effect of cisplatin on Y chromosomes
    Cem Akbal
    Department of Urology, Marmara University School of Medicine, Istanbul Turkey
    Urology 73:1145-9. 2009
    To investigate the impact of cisplatin (CP) on the testes-specific protein, Y-linked (TSPY) gene situated on the Y chromosome.
  40. ncbi A mapping and evolutionary study of porcine sex chromosome genes
    Claire R Quilter
    Human Molecular Genetics Group, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Mamm Genome 13:588-94. 2002
    ..of 10 NRY genes were found, and the following order was established: Ypter-(AMELY-EIF2S3Y/ZFY-USP9Y-DBY/UTY)-(TSPY-SMCY-UBE1Y-SRY)-CEN. This gene order showed greater conservation with the murine Y than with the human Y Chr...
  41. ncbi Why human extragonadal germ cell tumours occur in the midline of the body: old concepts, new perspectives
    J Wolter Oosterhuis
    Department of Pathology, Erasmus University Medical Center, Josephine Nefkens Institute, Rotterdam, The Netherlands
    Int J Androl 30:256-63; discussion 263-4. 2007
    ..tumours develop have in common that they contain feeder cells expressing stem cell factor (SCF) - the ligand for the SCF receptor c-KIT, involved in proliferation and survival of PGCs/gonocytes - and contain GBY including the gene TSPY.
  42. ncbi Organization and concerted evolution of the ampliconic Y-chromosomal TSPY genes from cattle
    Edward L C Verkaar
    Faculty of Veterinary Medicine, Yalelaan 1, 3584 CL Utrecht, The Netherlands
    Genomics 84:468-74. 2004
    The Y-chromosomal gene TSPY (testis-specific protein Y-encoded) is probably involved in early spermatogenesis and has a variable copy number in different mammalian species...
  43. ncbi Organization and expression of bovine TSPY
    T Vogel
    Institut fur Humangenetik, Medizinische Hochschule Hannover, D 30623 Hannover, Germany
    Mamm Genome 8:491-6. 1997
    ..genomic sequences as well as transcripts from the bovine homolog of the human testis-specific protein, Y-encoded, TSPY which-in both species-is located on the Y Chromosome (Chr), organized as a gene family with a variable number of ..
  44. ncbi Identification of differentially expressed nucleolar TGF-beta1 target (DENTT) in human lung cancer cells that is a new member of the TSPY/SET/NAP-1 superfamily
    L L Ozbun
    Department of Cell and Cancer Biology, National Cancer Institute, Medicine Branch, 9610 Medical Center Drive, Rockville, MD 20850, USA
    Genomics 73:179-93. 2001
    ..DENTT contains a conserved 191-residue domain that shows significant identity to, and defines, the TSPY/TSPY-like/SET/NAP-1 superfamily...
  45. ncbi Differentially expressed nucleolar TGF-beta1 target (DENTT) in mouse development
    Laurent L Ozbun
    National Cancer Institute, Cell and Cancer Biology Branch, Rockville, Maryland 20850, USA
    Dev Dyn 226:491-511. 2003
    ..differentially affected by TGF-beta1 in TGF-beta1-responsive human lung cancer cells and who is a new member of the TSPY/TSPY-like/SET/NAP-1 (TTSN) protein superfamily...
  46. ncbi Differentially expressed nucleolar TGF-beta1 target (DENTT) shows tissue-specific nuclear and cytoplasmic localization and increases TGF-beta1-responsive transcription in primates
    Laurent L Ozbun
    National Cancer Institute, Cell and Cancer Biology Branch, 9610 Medical Center Drive, Suite 300, Rockville, MD 20850, USA
    Biochim Biophys Acta 1728:163-80. 2005
    Differentially Expressed Nucleolar TGF-beta1 Target (DENTT) is a new member of the TSPY/TSPY-like/SET/NAP-1 (TTSN) superfamily whose mRNA is induced by TGF-beta1 in TGF-beta1-responsive human lung cancer cells...
  47. pmc TSPY is a cancer testis antigen expressed in human hepatocellular carcinoma
    Y H Yin
    Immunology Department, Peking University Health Science Center, Beijing, China
    Br J Cancer 93:458-63. 2005
    ..for genes associated with hepatocellular carcinoma (HCC) by cDNA microarray, we found that the transcription of TSPY, 'testis-specific protein Y-encoded', was upregulated in HCC...
  48. ncbi Direct quantification of fetal cells in maternal blood by real-time PCR
    Xiao Yan Zhong
    Laboratory for Prenatal Medicine and Experimental Oncology, Department of Research, University Women s Hospital Basel, Basel, Switzerland
    Prenat Diagn 26:850-4. 2006
    ..We developed a simple, robust TaqMan real-time PCR assay to directly quantify male fetal cells in maternal blood using the multi-copy DYS14, without the need for any additional enrichment procedure.
  49. ncbi A human candidate spermatogenesis gene, RBM1, is conserved and amplified on the marsupial Y chromosome
    M L Delbridge
    School of Genetics and Human Variation, La Trobe University, Bundoora, Victoria, Australia
    Nat Genet 15:131-6. 1997
    Three genes, RBM1, DAZ and TSPY, map to a small region of the long arm of the human Y chromosome which is deleted in azoospermic men. RBM1, but not DAZ or TSPY, has a Y-linked homologue in marsupials which is transcribed in the testis...
  50. ncbi High-resolution fluorescence in situ hybridization of human Y-linked genes on released chromatin
    B Glaser
    Institute of Human Genetics and Anthropology, University of Freiburg, Germany
    Chromosome Res 5:23-30. 1997
    ..hybridization technique as an alternative strategy for physically mapping the PRKY and AMELY genes as well as the TSPY, RBM and DAZ gene families to human Y chromosomes in prometaphase and to extended Y chromatin in interphase...
  51. ncbi Retroactive DNA analysis for sex determination and dystrophin gene by polymerase chain reaction with archived cytogenetic slides
    S K Choi
    Samsung Cheil Hospital and Women s Healthcare Center, Medical Research Institute, Sungkyunkwan University, Seoul, Korea
    Exp Mol Med 31:36-41. 1999
    ..the marker chromosome was derived from Y chromosome, we studied the six loci (PABY, SRY, RPS4Y (SY16, 17), ZFY, DYS14) on the short arm, one locus (DYZ3) on the centromere and one locus (DYZ1) on the long arm...
  52. ncbi Fetal gender determination in early pregnancy through qualitative and quantitative analysis of fetal DNA in maternal serum
    Hiroshi Honda
    Department of Obstetrics and Gynecology, Hiroshima University School of Medicine, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Hum Genet 110:75-9. 2002
    ..Fetal gender was determined by conventional polymerase chain reaction (PCR) to detect a Y-chromosomal sequence (DYS14) in maternal serum during early gestation and confirmed by examination of the newborns after delivery...
  53. ncbi A fiber-FISH contig spanning the non-recombining region of the human Y chromosome
    Susanne Röttger
    Institute of Human Genetics and Anthropology, University of Freiburg, Breisacher Str 33, 79106 Freiburg, Germany
    Chromosome Res 10:621-35. 2002
    ..used signals of these marker clones to build a fiber-FISH contig for the multicopy gene families, CDY, DAZ, RBMY, TSPY and XKRY, along the NRY...
  54. ncbi Paternal, maternal, and biparental molecular markers provide unique windows onto the evolutionary history of macaque monkeys
    Anthony J Tosi
    Department of Anthropology, Columbia University, New York, New York 10027, USA
    Evolution 57:1419-35. 2003
    ..1 Kb) consists of the genes SRY and TSPY; the two autosomal datasets include IRBP intron 3 (1.6 Kb) and the 5' half of C4 "long" intron 9 (3.3 Kb)...
  55. ncbi [Screening for Y chromosome sequences in patients with Turner syndrome]
    Lénia Ferrão
    Centro de Genética Humana, Instituto Nacional de Saude Dr Ricardo Jorge, Lisboa
    Acta Med Port 15:89-100. 2002
    ..was carried out by simplex PCR and by nested PCR of the following Y specific loci: SRY (sex determining region Y), TSPY (testis specific protein Y encoded), DYZ3 (centromeric locus) and DAZ1 (deleted in azoospermia)...
  56. ncbi Developmental model for the pathogenesis of testicular carcinoma in situ: genetic and environmental aspects
    Ewa Rajpert-De Meyts
    University Department of Growth and Reproduction, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Hum Reprod Update 12:303-23. 2006
    ..g. PLAP and KIT), some of the germ cell-specific markers (e.g. MAGEA4, VASA, TSPY and NY-ESO-1), supported by studies of regulatory elements of the cell cycle (e.g...
  57. ncbi Tspy is nonfunctional in the Mongolian gerbil but functional in the Syrian hamster
    Violetta Karwacki
    Institute of Human Genetics, Medical School Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    Genomics 88:65-73. 2006
    The TSPY gene is conserved in placental mammals and encodes the testis-specific protein, Y encoded...
  58. ncbi Detection of cell-free fetal DNA in maternal urine
    S Illanes
    Fetal Medicine Research Unit, Division of Obstetrics and Gynaecology, University of Bristol, Bristol, UK
    Prenat Diagn 26:1216-8. 2006
    ..To evaluate the presence of cell-free fetal DNA signals in maternal urine as a potential source of material for non-invasive prenatal diagnosis...
  59. pmc Structural variation on the short arm of the human Y chromosome: recurrent multigene deletions encompassing Amelogenin Y
    Mark A Jobling
    Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK
    Hum Mol Genet 16:307-16. 2007
    ..mapping strongly implicates a mechanism of non-allelic homologous recombination between the proximal major array of TSPY gene-containing repeats, and a single distal copy of TSPY; this is supported by the estimation of TSPY copy number ..
  60. doi Foreign fetal cells persist in the maternal circulation
    Zev Williams
    Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Fertil Steril 91:2593-5. 2009
    ..To determine whether allogenic fetal cells resulting from donor egg pregnancies persist in maternal circulation...
  61. ncbi [Noninvasive fetal sex detection from maternal plasma in pregnant women]
    R Vodicka
    Ustav lékarské genetiky a fetální medicíny, Fakultnńemocnice Olomouc
    Ceska Gynekol 73:150-3. 2008
    ..Objective of our study was optimization of noninvasive fetal sex detection from maternal plasma in pregnant women...
  62. ncbi [Preliminary application of MLPA-based array in detecting Y chromosome abnormalities]
    Da wen Zhou
    Shanghai Institute of Medical Genetics, School of Medicine, and Center Laboratory, Shanghai Children s Hospital, Shanghai Jiao Tong University, Shanghai 200040, China
    Yi Chuan 30:1629-34. 2008
    ..in detecting sex chromosome abnormalities, MLPA probes were designed to target against three gene loci, TSPY (p11.2), PRY (q11), and RBMY (q11.2) in human Y chromosome...
  63. doi Detection of increased amounts of cell-free fetal DNA with short PCR amplicons
    Aleksandra Sikora
    Department of Biomedicine, University Women s Hospital, Basel, Switzerland
    Clin Chem 56:136-8. 2010
    ....
  64. doi Partial rescue of the KIT-deficient testicular phenotype in KitW-v/KitW-v Tg(TSPY) mice
    Anja Schöner
    Institutes of Human Genetics and Biometry, Hannover Medical School, Hannover, Germany
    Biol Reprod 83:20-6. 2010
    b>TSPY encodes the testis-specific protein Y-linked. In man, expression of TSPY is restricted to the testis, where TSPY is expressed in spermatogonia, primary spermatocytes, and round spermatids, and to the prostate gland...
  65. doi OCT4 gonadal gene expression related to the presence of Y-chromosome sequences in Turner syndrome
    Bianca Bianco
    Division of Endocrinology, Department of Medicine, Federal University of Sao Paulo, Sao Paulo, Brazil
    Fertil Steril 94:2347-9. 2010
    ..no significant difference was found regarding the expression of the genes DAX1, FOG2, GATA4, OCT4, SF1, SRY, TSPY, WT1, and STRA8 compared with controls, except for genes OCT4, SRY, and TSPY in both gonads of a patient whose ..
  66. doi Tumor risk in disorders of sex development
    J Pleskacova
    Department of Pediatrics, Charles University, 2nd Faculty of Medicine, Prague, Czech Republic
    Sex Dev 4:259-69. 2010
    ..Also TSPY (testis-specific protein Y-encoded), the main candidate for the so-called gonadoblastoma locus on Y chromosome, is ..
  67. doi Expression of the human TSPY gene in the brains of transgenic mice suggests a potential role of this Y chromosome gene in neural functions
    Tatsuo Kido
    Division of Cell and Developmental Genetics, Department of Medicine, VA Medical Center, and Institute for Human Genetics, University of California, San Francisco, CA 94121, USA
    J Genet Genomics 38:181-91. 2011
    The testis specific protein Y-encoded (TSPY) is a member of TSPY/SET/NAP1 superfamily, encoded within the gonadoblastoma locus on the Y chromosome...
  68. doi Malignant ovarian germ cell tumours in gonadal Y chromosome mosaicism
    Reza Shahsiah
    Department of Pathology, Tehran University of Medical Sciences, Tehran, Iran
    J Clin Pathol 64:973-6. 2011
    ..The aim of this study was to evaluate the frequency of Y chromosome material in these tumours...
  69. doi Effective detection of fetal sex using circulating fetal DNA in first-trimester maternal plasma
    Ji Hyae Lim
    Kwan Dong University College of Medicine, Seoul, Korea
    FASEB J 26:250-8. 2012
    ..Multiplex real-time PCR was used to simultaneously quantify the amount of DYS14 and GAPDH in maternal plasma. The results were confirmed by phenotype at birth...
  70. doi Testis-specific protein Y-encoded copy number is correlated to its expression and the field fertility of Canadian Holstein bulls
    C K Hamilton
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ont, Canada
    Sex Dev 6:231-9. 2012
    Testis-specific protein Y-encoded (TSPY) is present in varying copy number in both human (20-76 copies) and cattle (37-200 copies), and some studies have linked this variation to semen quality in men...
  71. pmc Gene entropy-fractal dimension informatics with application to mouse-human translational medicine
    T Holden
    Queensborough Community College of CUNY, 222 05 56th Avenve Bayside, NY 11364, USA
    Biomed Res Int 2013:582358. 2013
    ..The Y-chromosome DYS14 in fetal micro chimerism that could offer protection from Alzheimer's disease is given as an example.
  72. pmc Transgenic Mouse Studies to Understand the Regulation, Expression and Function of the Testis-Specific Protein Y-Encoded (TSPY) Gene
    Stephanie Schubert
    Institute of Human Genetics, Hannover Medical School, D 30625 Hannover, Germany
    Genes (Basel) 1:244-62. 2010
    The TSPY gene, which encodes the testis-specific protein, Y-encoded, was first discovered and characterized in humans, but orthologous genes were subsequently identified on the Y chromosome of many other placental mammals...
  73. pmc Molecular analysis of testis biopsy and semen pellet as complementary methods with histopathological analysis of testis in non-obstructive azoospermia
    Maryam Eghbali
    Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Poursina Ave, 16 Azar St Keshavarz BLVD, Tehran, Iran, 1417613151
    J Assist Reprod Genet 31:707-15. 2014
    ..Therefore, we evaluated sperm production through analyses of germ cell-specific transcripts (DAZ, TSPY1, SPTRX3 and SPTRX1) in semen and testicular biopsies of men with azoospermia...
  74. doi Maternal smoking does not affect the amount of cell-free fetal DNA in maternal plasma during the 1st trimester of pregnancy
    F Tarquini
    Department of Obstetrics and Gynaecology, University of Perugia, Perugia, Italy
    J Obstet Gynaecol 35:42-5. 2015
    ..33 ex-smoking pregnant women at 11 (+0)-13 (+6) gestational weeks, was extracted and quantified by the multicopy DYS14, as the fetal DNA marker and using the quantitative real-time PCR 7300 detection system...
  75. doi [Research progress of TSPY1 gene family]
    Ying Shen
    Department of Medical Genetics, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 31:600-3. 2014
    ..In this review, the structure characteristics of the gene family were illustrated, and the functional studies of TSPY1 in the process of tumorigenesis and spermatogenesis were discussed. ..
  76. doi Blastocele fluid from in vitro- and in vivo-produced equine embryos contains nuclear DNA
    C Herrera
    Instituto de Investigaciones Biotecnológicas IIB INTECH Dr Rodolfo Ugalde, Universidad Nacional de San Martin, San Martin, Buenos Aires, Argentina Cría Tanoira Embriones, Pilar, Buenos Aires, Argentina Electronic address
    Theriogenology 83:415-20. 2015
    ..DNA could be used to diagnose the sex of the embryos by conventional PCR, using specific primers that target the TSPY and AMEL equine genes...
  77. pmc Copy number variation in the human Y chromosome in the UK population
    Wei Wei
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK
    Hum Genet 134:789-800. 2015
    ..duplication encompassing the AMELY and TBL1Y genes that probably has no phenotypic effect, partial deletions of the TSPY cluster and AZFc region that may influence spermatogenesis, and other variants with unknown functional implications,..
  78. doi Mitochondrial DNA and two Y-chromosome genes of common long-tailed macaques (Macaca fascicularis fascicularis) throughout Thailand and vicinity
    Srichan Bunlungsup
    Faculty of Science, Department of Biology, Chulalongkorn University, Bangkok, Thailand
    Am J Primatol 79:1-13. 2017
    ..using mitochondrial DNA (mtDNA), including the hypervariable region 1, and Y-chromosomal DNA, including SRY and TSPY genes. The mtDNA phylogenetic analysis divided M. f...
  79. doi Identification of a TSPY co-expression network associated with DNA hypomethylation and tumor gene expression in somatic cancers
    Tatsuo Kido
    Division of Cell and Developmental Genetics, Department of Medicine, Veterans Affairs Medical Center, and Institute for Human Genetics, University of California, San Francisco, CA 94121, USA
    J Genet Genomics 43:577-585. 2016
    Testis specific protein Y-encoded (TSPY) is a Y-located proto-oncogene predominantly expressed in normal male germ cells and various types of germ cell tumor...
  80. ncbi X-chromosomal localization of mammalian Y-linked genes in two XO species of the Ryukyu spiny rat
    Y Arakawa
    Laboratory of Ecology and Genetics, Graduate School of Environmental Earth Science, Hokkaido University, Sapporo, Japan
    Cytogenet Genome Res 99:303-9. 2002
    ..osimensis and in one male and one female of Tokudaia sp. Fluorescence in situ hybridization with the Tspy (testis-specific protein, Y-encoded) gene from both male and female cells of Tokudaia sp...
  81. doi Gonadoblastoma-associated mixed germ cell tumour in 46,XY complete gonadal dysgenesis (Swyer syndrome): analysis of Y chromosomal genotype and OCT3/4 and TSPY expression profile
    S B Ng
    Histopathology 52:644-6. 2008
  82. ncbi Molecular cytogenetic techniques in detecting subtle chromosomal imbalances
    Bogdan Kałuzewski
    Department of Medical Genetics, Medical University of Łódź, Łódź, Poland
    J Appl Genet 44:539-46. 2003
    ..on the short arm of chromosome X was confirmed by the FISH technique, employing two Yp-specific probes for SRY and TSPY genes...
  83. ncbi Pathobiological implications of the expression of markers of testicular carcinoma in situ by fetal germ cells
    Friedemann Honecker
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC University Medical Center Rotterdam, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    J Pathol 203:849-57. 2004
    ..In addition to these markers, the presence of VASA (a protein specific for the germ cell lineage), TSPY (the testis-specific protein, Y-encoded), and the proliferation index (Ki-67 antigen) was analysed...
  84. ncbi TSPY detection in blood, buccal, and urine cells of patients with 45,X karyotype
    Ana Karina Bartmann
    Am J Med Genet A 130:320-1. 2004
  85. ncbi Mice overexpression of human augmenter of liver regeneration (hALR) in male germ cells shows abnormal spermatogenesis and reduced fertility
    Yan Cao
    Beijing Institute of Radiation Medicine, Beijing, China
    Endocr J 59:989-99. 2012
    ..physiological effects of hALR in spermatogenesis, we generated a hALR transgenic mouse model driven by the human TSPY (testis-specific protein, Y-encoded) promoter that allows the transgene to be specifically activated in the testes...
  86. pmc Fetal-maternal interactions in the synepitheliochorial placenta using the eGFP cloned cattle model
    Flavia Thomaz Verechia Pereira
    University Estadual Paulista, Campus of Dracena, Dracena, Brazil
    PLoS ONE 8:e64399. 2013
    ..In addition, we searched for male specific DNA in the blood of females carrying in vitro produced male embryos. Our hypothesis is that the bovine placenta is more permeable to fetal-derived products than described elsewhere...
  87. pmc Prevalence of c-KIT mutations in gonadoblastoma and dysgerminomas of patients with disorders of sex development (DSD) and ovarian dysgerminomas
    Remko Hersmus
    Department of Pathology, Erasmus MC University Medical Center Rotterdam, Josephine Nefkens Institute, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    PLoS ONE 7:e43952. 2012
    ..The results are combined with data on TSPY and OCT3/4 expression in a series of 16 DSD patients presenting with gonadoblastoma and dysgerminoma and 15 ..
  88. doi Sexing single bovine blastomeres using TSPY gene amplification
    M C A Carneiro
    Departamento de Genetica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil
    Genet Mol Res 10:3937-41. 2011
    The testis-specific protein Y-encoded gene (TSPY) is a Y-specific gene present in variable copy number in many mammalian species, including cattle...
  89. doi A novel approach to sexing bovine blastocysts using male-specific gene expression
    C K Hamilton
    Department of Biomedical Sciences, University of Guelph, Guelph, ON, Canada
    Theriogenology 77:1587-96. 2012
    ..objective of this study was to systematically examine eight Y chromosome linked genes (DDX3Y, EIF1AY, HSFY, SRY, TSPY, USP9Y, ZFY, and ZRSR2Y) to characterize their expression in bovine blastocysts and to examine the usefulness of ..
  90. pmc A human Y-chromosomal DNA sequence expressed in testicular tissue
    J Arnemann
    Institut fur Humangenetik, Universitat Gottingen, FRG
    Nucleic Acids Res 15:8713-24. 1987
    Clone pJA36B (DYS14) was isolated from a human Y chromosome enriched cosmid library. Southern blot analysis revealed a male-specific hybridization pattern...
  91. ncbi TSPY-related sequences represent a microheterogeneous gene family organized as constitutive elements in DYZ5 tandem repeat units on the human Y chromosome
    E Manz
    Institut fur Humangenetik, Medizinische Hochschule Hannover, Germany
    Genomics 17:726-31. 1993
    b>TSPY (testis-specific protein, Y-encoded) is encoded by members of a Y-chromosome-specific sequence family. We show here that TSPY elements are part of the DYZ5 repeat unit...
  92. ncbi A comparison of TSPY genes from Y-chromosomal DNA of the great apes and humans: sequence, evolution, and phylogeny
    H S Kim
    Department of Cellular and Molecular Biology, Kyoto University, Aichi, Japan
    Am J Phys Anthropol 100:301-9. 1996
    The genes for testis-specific protein Y (TSPY) were sequenced from chimpanzee (Pan troglodytes), gorilla (Gorilla gorilla), orangutan (Pongo pygmaeus), and baboon (Papio hamadryas)...
  93. ncbi Rodent Y chromosome TSPY gene is functional in rat and non-functional in mouse
    S Mazeyrat
    INSERM U406, Faculte de Medecine, 27 Boulevard Jean Moulin, 13385 Marseille, France
    Hum Mol Genet 7:557-62. 1998
    ..Here we present definitive evidence that functional Y genes can be lost from the mammalian genome. TSPY genes must have been selectively maintained on the mammalian Y chromosome since before the radiation of eutheria, ..
  94. ncbi A murine TSPY
    T Vogel
    Institute of Human Genetics, Medizinische Hochschule Hannover, Germany
    Chromosome Res 6:35-40. 1998
    Sequences homologous to human and bovine TSPY were isolated from M. musculus testicular cDNA, and a nearly full-length gene was polymerase chain reaction (PCR) amplified from mouse genomic DNA. This gene is apparently non-functional...
  95. ncbi The mouse Y chromosome interval necessary for spermatogonial proliferation is gene dense with syntenic homology to the human AZFa region
    S Mazeyrat
    INSERM U491, Faculte de Medecine, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France
    Hum Mol Genet 7:1713-24. 1998
    ..from two novel genes were isolated and placed together with Dffry and Uty on the contig in the order Dffry-Dby-Uty-Tspy-Eif2gammay-Smcy- Ube1y-Zfy1...
  96. ncbi Silencing of the Y-chromosomal gene tspy during murine evolution
    S Schubert
    Institut fur Humangenetik, Medizinische Hochschule, Hannover, Germany
    Mamm Genome 11:288-91. 2000
    We have studied the process of tspy gene silencing in murine evolution. We have isolated functional tspy sequences from Apodemus agrarius, A. sylvaticus, A...
  97. ncbi Successful diagnosis of fetal gender using conventional PCR analysis of maternal serum
    H Honda
    Department of Obstetrics and Gynecology, Hiroshima University School of Medicine, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Clin Chem 47:41-6. 2001
    ..Fetal DNA has been found in maternal plasma and serum. Diagnosis of fetal gender using maternal plasma and serum has been attempted in an effort to develop a new noninvasive method of prenatal diagnosis...
  98. ncbi SET-related cell division autoantigen-1 (CDA1) arrests cell growth
    Z Chai
    Department of Pathology and Immunology, Monash University Medical School, Prahran, Victoria 3181, Australia
    J Biol Chem 276:33665-74. 2001
    ..The same basic region is also homologous to nucleosome assembly proteins, testis TSPY protein, and an uncharacterized brain protein...
  99. ncbi Mosaic AZF deletions and susceptibility to testicular tumors
    Nestor O Bianchi
    Instituto Multidisciplinario de Biología Celular IMBICE, La Plata, Argentina
    Mutat Res 503:51-62. 2002
    ..We propose that AZF deletions occur in early embryogenesis due to mutations of TSPY, mismatch repair (MMR), or X-specific genes...
  100. ncbi Expression of differentially expressed nucleolar transforming growth factor-beta1 target (DENTT) in adult mouse tissues
    Alfredo Martinez
    National Cancer Institute, Cell and Cancer Biology Branch, Rockville, Maryland, 20850, USA
    Dev Dyn 224:186-99. 2002
    Differentially expressed nucleolar TGF-beta1 target (DENTT) is a novel member of the TSPY/TSPY-L/SET/NAP-1 (TTSN) superfamily that we have previously identified in human lung cancer cells...
  101. ncbi Engraftment assessment in human and mouse liver tissue after sex-mismatched liver cell transplantation by real-time quantitative PCR for Y chromosome sequences
    Ling Jia Wang
    Department of Pediatrics, Northwestern University, Children s Memorial Hospital, Children s Memorial Institute for Education and Research, Chicago, IL 60614, USA
    Liver Transpl 8:822-8. 2002
    ..and probes complementary to human testis determining gene (SRY) and mouse testis-specific Y-encoded protein (TSPY) pseudogene...

Research Grants2

  1. Yun Fai Chris Lau; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): The testis-specific protein Y-encoded (TSPY) gene is a tandemly repeated gene on the short arm of the human Y chromosome. Its 2...
  2. FUNCTIONS OF SRY AND SRY INTERACTIVE PROTEIN GENES
    Yun Fai Chris Lau; Fiscal Year: 2004
    ..Understanding the mechanisms of sex determination in mouse may shed insights on those in humans, and eventually may lead to developments of clinical diagnosis and treatment of gonadal dysgenesis and infertility. ..