ZnT 8

Summary

Gene Symbol: ZnT 8
Description: solute carrier family 30 member 8
Alias: ZNT8, ZnT-8, zinc transporter 8, solute carrier family 30 (zinc transporter), member 8, zinc transporter ZnT-8
Species: human

Top Publications

  1. ncbi ZnT-8, a pancreatic beta-cell-specific zinc transporter
    Fabrice Chimienti
    Laboratoire des Lésions des Acides Nucléiques, DRFMC SCIB LAN, CEA Grenoble, 17, rue des Martyrs, 38054, Grenoble Cedex 9, France
    Biometals 18:313-7. 2005
  2. ncbi Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9
    Silke Overbeck
    Institute of Immunology, RWTH Aachen University Hospital, Pauwelsstrasse 30, D 52074 Aachen, Germany
    J Leukoc Biol 83:368-80. 2008
  3. doi Prediction and prevention of Type 1 diabetes mellitus
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Diabetes 3:48-57. 2011
  4. ncbi Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules
    Fabrice Chimienti
    DRFMC SCIB LAN, CEA Grenoble, 17, rue des Martyrs, 38054 Grenoble Cedex 9, France
    Diabetes 53:2330-7. 2004
  5. doi Predictive power of screening for antibodies against insulinoma-associated protein 2 beta (IA-2beta) and zinc transporter-8 to select first-degree relatives of type 1 diabetic patients with risk of rapid progression to clinical onset of the disease: impli
    J De Grijse
    Diabetes Research Center, Brussels Free University VUB, Laarbeeklaan 103, B 1090 Brussels, Belgium
    Diabetologia 53:517-24. 2010
  6. pmc Down-regulation of ZnT8 expression in INS-1 rat pancreatic beta cells reduces insulin content and glucose-inducible insulin secretion
    Yi Fu
    Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 4:e5679. 2009
  7. doi HHEX-IDE polymorphism is associated with low birth weight in offspring with a family history of type 1 diabetes
    Christiane Winkler
    Institut fuer Diabetesforschung der Forschergruppe Diabetes e V at the Helmholtz Center Munich, 85764 Neuherberg, Germany
    J Clin Endocrinol Metab 94:4113-5. 2009
  8. doi Association between rs13266634 C/T polymorphisms of solute carrier family 30 member 8 (SLC30A8) and type 2 diabetes, impaired glucose tolerance, type 1 diabetes--a meta-analysis
    Kuanfeng Xu
    Department of Endocrinology, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, Jiangsu, PR China
    Diabetes Res Clin Pract 91:195-202. 2011
  9. pmc Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function
    Harald Staiger
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    PLoS ONE 2:e832. 2007
  10. ncbi Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function
    Laura Pascoe
    Diabetes Research Group, Newcastle University, Newcastle upon Tyne, UK
    Diabetes 56:3101-4. 2007

Research Grants

  1. Zinc Transporter-8-Specific T Cell Responses in the Prediction of Type 1 Diabetes
    HELENA KRISTIINA REIJONEN; Fiscal Year: 2013
  2. Analysis of diabetogenic human T cell receptors
    Howard W Davidson; Fiscal Year: 2011
  3. Christiane S Hampe; Fiscal Year: 2016
  4. Malek El Muayed; Fiscal Year: 2016
  5. Marian J Rewers; Fiscal Year: 2016
  6. The Environmental Triggers of Diabetes (TEDDY)
    Ake Lernmark; Fiscal Year: 2013
  7. MASSIMO T PIETROPAOLO; Fiscal Year: 2014
  8. Howard W Davidson; Fiscal Year: 2014
  9. High throughput Point-of-Care assays for diabetes auto-antibody detection
    KUMAR SUBRAMANIAN; Fiscal Year: 2013
  10. REGULATION OF HEPATIC INSULIN EXTRACTION
    Kenneth S Polonsky; Fiscal Year: 2013

Detail Information

Publications143 found, 100 shown here

  1. ncbi ZnT-8, a pancreatic beta-cell-specific zinc transporter
    Fabrice Chimienti
    Laboratoire des Lésions des Acides Nucléiques, DRFMC SCIB LAN, CEA Grenoble, 17, rue des Martyrs, 38054, Grenoble Cedex 9, France
    Biometals 18:313-7. 2005
    ..We discovered mammalian orthologs (rat, mouse, chimpanzee, and dog) and found these ZnT-8 proteins very similar (98% conserved amino acids) to human ZnT-8, indicating a high conservation during evolution...
  2. ncbi Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9
    Silke Overbeck
    Institute of Immunology, RWTH Aachen University Hospital, Pauwelsstrasse 30, D 52074 Aachen, Germany
    J Leukoc Biol 83:368-80. 2008
    ..These data provide insight into the regulation of intracellular zinc homeostasis in cells of the immune system and may explain the variable effects of zinc deficiency on different leukocyte subsets...
  3. doi Prediction and prevention of Type 1 diabetes mellitus
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Diabetes 3:48-57. 2011
    ..against insulin, glutamic acid decarboxylase 65, insulinoma antigen (IA)-2 (ICA512) and the zinc transporter ZnT8. We can also prevent T1DM in animal models, but the final goal is the prevention of T1DM in humans...
  4. ncbi Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules
    Fabrice Chimienti
    DRFMC SCIB LAN, CEA Grenoble, 17, rue des Martyrs, 38054 Grenoble Cedex 9, France
    Diabetes 53:2330-7. 2004
    ....
  5. doi Predictive power of screening for antibodies against insulinoma-associated protein 2 beta (IA-2beta) and zinc transporter-8 to select first-degree relatives of type 1 diabetic patients with risk of rapid progression to clinical onset of the disease: impli
    J De Grijse
    Diabetes Research Center, Brussels Free University VUB, Laarbeeklaan 103, B 1090 Brussels, Belgium
    Diabetologia 53:517-24. 2010
    ..for insulinoma-associated protein (IA-2) beta (IA-2beta) autoantibodies (IA-2betaA) and zinc transporter-8 (ZnT8) autoantibodies (ZnT8A) improves identification of first-degree relatives of type 1 diabetic patients with a high 5-..
  6. pmc Down-regulation of ZnT8 expression in INS-1 rat pancreatic beta cells reduces insulin content and glucose-inducible insulin secretion
    Yi Fu
    Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 4:e5679. 2009
    The SLC30A8 gene codes for a pancreatic beta-cell-expressed zinc transporter, ZnT8. A polymorphism in the SLC30A8 gene is associated with susceptibility to type 2 diabetes, although the molecular mechanism through which this phenotype is ..
  7. doi HHEX-IDE polymorphism is associated with low birth weight in offspring with a family history of type 1 diabetes
    Christiane Winkler
    Institut fuer Diabetesforschung der Forschergruppe Diabetes e V at the Helmholtz Center Munich, 85764 Neuherberg, Germany
    J Clin Endocrinol Metab 94:4113-5. 2009
    ....
  8. doi Association between rs13266634 C/T polymorphisms of solute carrier family 30 member 8 (SLC30A8) and type 2 diabetes, impaired glucose tolerance, type 1 diabetes--a meta-analysis
    Kuanfeng Xu
    Department of Endocrinology, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, Jiangsu, PR China
    Diabetes Res Clin Pract 91:195-202. 2011
    ..To investigate the association of solute carrier family 30 member 8 (SLC30A8) rs13266634 C/T polymorphism with type 2 diabetes (T2DM), impaired glucose tolerance (IGT), and type 1 diabetes (T1DM)...
  9. pmc Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function
    Harald Staiger
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    PLoS ONE 2:e832. 2007
    ..However, associations of these variations with insulin resistance and/or beta-cell dysfunction were not assessed...
  10. ncbi Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function
    Laura Pascoe
    Diabetes Research Group, Newcastle University, Newcastle upon Tyne, UK
    Diabetes 56:3101-4. 2007
    ..Our objective was to explore the relationships between the diabetes-associated alleles and measures of beta-cell function and whole-body insulin sensitivity...
  11. doi Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion
    K Kirchhoff
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, Eberhard Karls Universitat Tubingen, Otfried Muller Str 10, 72076 Tubingen, Germany
    Diabetologia 51:597-601. 2008
    ..We investigated whether these polymorphisms are also associated with impaired proinsulin to insulin conversion...
  12. doi Genetic analysis of recently identified type 2 diabetes loci in 1,638 unselected patients with type 2 diabetes and 1,858 control participants from a Norwegian population-based cohort (the HUNT study)
    J K Hertel
    Department of Clinical Medicine, University of Bergen, Bergen, Norway
    Diabetologia 51:971-7. 2008
    ..To get a better estimation of the true risk conferred by these novel loci, we tested a completely unselected population of type 2 diabetes patients from a Norwegian health survey (the HUNT study)...
  13. doi Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes
    N Pulizzi
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Diabetologia 52:825-9. 2009
    ....
  14. doi The inhibitory effect of recent type 2 diabetes risk loci on insulin secretion is modulated by insulin sensitivity
    Axel Haupt
    Medical Clinic, Department of Endocrinology, Metabolism, Nephrology and Angiology, Otfried Muller Strasse 10, 72076 Tubingen, Germany
    J Clin Endocrinol Metab 94:1775-80. 2009
    ..We assessed whether the risk alleles in TCF7L2, CDKAL1, HHEX, SLC30A8, IGF2BP2, CDKN2A/2B, JAZF1, and WFS1 reduce insulin secretion in an additive manner and whether their impact is influenced by insulin sensitivity...
  15. pmc In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression
    Michel Seve
    DRFMC SCIB LAN, CEA Grenoble, Grenoble, France
    BMC Genomics 5:32. 2004
    ..ZnT proteins are members of the cation diffusion facilitator (CDF) family of metal ion transporters...
  16. ncbi In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion
    Fabrice Chimienti
    DRFMC SCIB LAN, UMR E3 CEA UJF, CEA Grenoble, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France
    J Cell Sci 119:4199-206. 2006
    ..e. >10 mM glucose. Altogether, these data strongly suggest that the zinc transporter ZnT-8 is a key protein for both zinc accumulation and regulation of insulin secretion in pancreatic beta cells...
  17. ncbi A genome-wide association study identifies novel risk loci for type 2 diabetes
    Robert Sladek
    Department of Human Genetics, McGill University and Genome Quebec Innovation Centre, Montreal H3A 1A4, Canada
    Nature 445:881-5. 2007
    ..These associations explain a substantial portion of disease risk and constitute proof of principle for the genome-wide approach to the elucidation of complex genetic traits...
  18. ncbi A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
    Valgerdur Steinthorsdottir
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 39:770-5. 2007
    ..The insulin response for homozygotes was approximately 20% lower than for heterozygotes or noncarriers, suggesting that this variant confers risk of T2D through reduced insulin secretion...
  19. ncbi Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
    Richa Saxena
    Broad Institute of Harvard and Massachusetts Institute of Technology MIT, Cambridge, MA 02142, USA
    Science 316:1331-6. 2007
    ..The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases...
  20. pmc A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
    Laura J Scott
    Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Science 316:1341-5. 2007
    ..This brings the number of T2D loci now confidently identified to at least 10...
  21. pmc Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    Eleftheria Zeggini
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
    Science 316:1336-41. 2007
    ..The regions identified underscore the importance of pathways influencing pancreatic beta cell development and function in the etiology of type 2 diabetes...
  22. ncbi Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population
    M Horikoshi
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Diabetologia 50:2461-6. 2007
    ..The aim of this study was to determine the association between single nucleotide polymorphisms (SNPs) in these genes and type 2 diabetes in participants from the Japanese population...
  23. pmc The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes
    Janet M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, 1775 North Ursula Street, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 104:17040-5. 2007
    ..A high-ranking candidate, the zinc transporter ZnT8 (Slc30A8), was targeted by autoantibodies in 60-80% of new-onset T1D compared with <2% of controls and <3% ..
  24. ncbi Polymorphisms in the IDE-KIF11-HHEX gene locus are reproducibly associated with type 2 diabetes in a Japanese population
    Yasushi Furukawa
    The First Department of Medicine, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8509, Japan
    J Clin Endocrinol Metab 93:310-4. 2008
    ..A genome-wide association study in the French population has detected that novel single-nucleotide polymorphisms (SNPs) in the IDE-KIF11-HHEX gene locus and the SLC30A8 gene locus are associated with susceptibility to type 2 diabetes...
  25. ncbi Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population
    Shintaro Omori
    Laboratory for Diabetic Nephropathy, SNP Research Center, RIKEN, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Diabetes 57:791-5. 2008
    ....
  26. doi Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study
    Stephane Cauchi
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    J Mol Med (Berl) 86:341-8. 2008
    ..E.S.I.R. prospective cohort. However, in contrast to TCF7L2, the contribution of novel loci to T2D incidence seems only modest in the general middle-aged French population and should be replicated in larger cohorts...
  27. doi Quantitative trait analysis of type 2 diabetes susceptibility loci identified from whole genome association studies in the Insulin Resistance Atherosclerosis Family Study
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Diabetes 57:1093-100. 2008
    ....
  28. doi The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients--the EUGENE2 study
    T W Boesgaard
    Steno Diabetes Center, Niels Steensens Vej 1, NLC2 12, DK 2820, Gentofte, Copenhagen, Denmark
    Diabetologia 51:816-20. 2008
    ..Here, we investigate whether the polymorphism is related to altered insulin release in response to intravenous and oral glucose loads in non-diabetic offspring of type 2 diabetic patients...
  29. pmc Association analysis of type 2 diabetes Loci in type 1 diabetes
    Hui Qi Qu
    Departments of Pediatrics and Human Genetics, McGill University, Montreal, Quebec, Canada
    Diabetes 57:1983-6. 2008
    ..To search for a possible association of type 1 diabetes with 10 validated type 2 diabetes loci, i.e., PPARG, KCNJ11, WFS1, HNF1B, IDE/HHEX, SLC30A8, CDKAL1, CDKN2A/B, IGF2BP2, and FTO/RPGRIP1L...
  30. pmc Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value
    Stephane Cauchi
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    PLoS ONE 3:e2031. 2008
    ..Our aims were to validate these markers in other European and non-European populations, then to assess their combined effect in a large French study comparing T2D and normal glucose tolerant (NGT) individuals...
  31. pmc Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians
    Maggie C Y Ng
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
    Diabetes 57:2226-33. 2008
    ..However, the implications of these genes in Asians are unclear...
  32. doi Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan
    Yukio Horikawa
    Department of Diabetes and Endocrinology, Division of Molecule and Structure, Gifu University School of Medicine, Gifu, Japan
    J Clin Endocrinol Metab 93:3136-41. 2008
    ....
  33. pmc The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies
    Stephane Cauchi
    CNRS UMR8090, Institut de Biologie de Lille, Génomique et Physiologie Moléculaire des Maladies Métaboliques, Lille, France
    BMC Med Genet 9:45. 2008
    ....
  34. pmc Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program
    Allan F Moore
    Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Diabetes 57:2503-10. 2008
    ....
  35. pmc A common nonsynonymous single nucleotide polymorphism in the SLC30A8 gene determines ZnT8 autoantibody specificity in type 1 diabetes
    Janet M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes 57:2693-7. 2008
    ..The type 2 diabetes nonsynonymous single nucleotide polymorphism (SNP) affecting aa(325) lies within the region of highest ZnT8 autoantibody (ZnT8A) binding, prompting an investigation of its relationship to type 1 diabetes.
  36. pmc Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk
    Hana Lango
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
    Diabetes 57:3129-35. 2008
    ..Here, we assess the ability of 18 confirmed type 2 diabetes variants to differentiate between type 2 diabetic case and control subjects...
  37. pmc Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk
    Dharambir K Sanghera
    Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    BMC Med Genet 9:59. 2008
    ....
  38. doi Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps
    M J Groenewoud
    Department of Molecular Cell Biology, Leiden University Medical Center LUMC, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Diabetologia 51:1659-63. 2008
    ..Genome-wide association studies have recently identified novel type 2 diabetes susceptibility gene regions. We assessed the effects of six of these regions on insulin secretion as determined by a hyperglycaemic clamp...
  39. doi Zinc transporter-8 gene (SLC30A8) is associated with type 2 diabetes in Chinese
    Jie Xiang
    Department of Endocrinology and Metabolism, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    J Clin Endocrinol Metab 93:4107-12. 2008
    ....
  40. pmc Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population
    Ying Wu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Diabetes 57:2834-42. 2008
    ..We aimed to replicate these observations in a population-based cohort of Chinese Hans and examine the associations of these variants with type 2 diabetes and diabetes-related phenotypes...
  41. pmc Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study
    Mandy van Hoek
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Diabetes 57:3122-8. 2008
    ..Genome-wide association (GWA) studies identified multiple new genetic variants that associate with type 2 diabetes. The predictive value of genetic testing for prediction of type 2 diabetes in the general population is unclear...
  42. doi Beta cell glucose sensitivity is decreased by 39% in non-diabetic individuals carrying multiple diabetes-risk alleles compared with those with no risk alleles
    L Pascoe
    The Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Diabetologia 51:1989-92. 2008
    ..The aim of this study was to test the cumulative effects of diabetes-risk alleles on measures of beta cell function in non-diabetic individuals...
  43. pmc Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians
    Rong Rong
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 58:478-88. 2009
    ..We investigated the association of these single nucleotide polymorphisms (SNPs) and some additional tag SNPs with type 2 diabetes and related quantitative traits in Pima Indians...
  44. pmc Genotype score in addition to common risk factors for prediction of type 2 diabetes
    James B Meigs
    General Medicine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 359:2208-19. 2008
    ..We tested the hypothesis that knowledge of these loci allows better prediction of risk than knowledge of common phenotypic risk factors alone...
  45. doi Clinical risk factors, DNA variants, and the development of type 2 diabetes
    Valeriya Lyssenko
    Department of Clinical Sciences, Lund University, Malmo, Sweden
    N Engl J Med 359:2220-32. 2008
    ..Type 2 diabetes mellitus is thought to develop from an interaction between environmental and genetic factors. We examined whether clinical or genetic factors or both could predict progression to diabetes in two prospective cohorts...
  46. pmc Replication study of candidate genes associated with type 2 diabetes based on genome-wide screening
    Yasuharu Tabara
    Department of Basic Medical Research and Education, Ehime University Graduate School of Medicine, Toon City, Ehime, Japan
    Diabetes 58:493-8. 2009
    ..A total of 11 previously reported single-nucleotide polymorphisms (SNPs) from the TCF7L2, CDKAL1, HHEX, IGF2BP2, CDKN2A/B, SLC30A8, and KCNJ11 genes were analyzed...
  47. pmc Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data
    Nicholas J Timpson
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Diabetes 58:505-10. 2009
    ..This study examined how differences in the BMI distribution of type 2 diabetic case subjects affected genome-wide patterns of type 2 diabetes association and considered the implications for the etiological heterogeneity of type 2 diabetes...
  48. doi Association between insulin secretion, insulin sensitivity and type 2 diabetes susceptibility variants identified in genome-wide association studies
    Stephanie May Ruchat
    Department of Preventive Medicine, Laval University, Quebec City, QC, Canada
    Acta Diabetol 46:217-26. 2009
    ..These variants were found to account for 2.0-8.5% of the variance of T2DM-related traits...
  49. doi SlC30A8 is a major target of humoral autoimmunity in type 1 diabetes and a predictive marker in prediabetes
    Janet M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA
    Ann N Y Acad Sci 1150:256-9. 2008
    ..The highest ranking candidate was Slc30A8 (zinc transporter 8; ZnT8), which was screened by radioimmunoprecipitation assays against new-onset T1D and prediabetic sera...
  50. doi The risk allele load accelerates the age-dependent decline in beta cell function
    A Haupt
    Medical Clinic, Department of Internal Medicine IV Diabetology, Endocrinology, Nephrology, Angiology, and Clinical Chemistry, Eberhard Karls University, Otfried Muller Strasse 10, 72076, Tubingen, Germany
    Diabetologia 52:457-62. 2009
    ..In the present study we examined the effect of these genes' risk alleles on the age-dependent decline in insulin secretion...
  51. pmc Type 2 diabetes risk alleles are associated with reduced size at birth
    Rachel M Freathy
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
    Diabetes 58:1428-33. 2009
    ..We tested whether common genetic variants that predispose to type 2 diabetes also reduce birth weight...
  52. ncbi Novel antigens in type 1 diabetes: the importance of ZnT8
    Janet M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, PO Box 6511, 1775 North Ursula Court, Aurora, CO 80045, USA
    Curr Diab Rep 9:105-12. 2009
    ..b>ZnT8 was recently defined as a candidate autoantigen based on a -bioinformatics analysis focused on discovery of beta-..
  53. pmc Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry
    Marilyn C Cornelis
    Harvard School of Public Health, Channing Laboratory, Boston, MA 02115, USA
    Ann Intern Med 150:541-50. 2009
    ..Genome-wide association studies have identified novel type 2 diabetes loci, each of which has a modest impact on risk...
  54. pmc Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men
    Alena Stancakova
    Department of Medicine, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
    Diabetes 58:2129-36. 2009
    ..We investigated the effects of 18 confirmed type 2 diabetes risk single nucleotide polymorphisms (SNPs) on insulin sensitivity, insulin secretion, and conversion of proinsulin to insulin...
  55. pmc Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants
    Tamara J Nicolson
    Section of Cell Biology, Division of Medicine, Imperial College London, London, U K
    Diabetes 58:2070-83. 2009
    ..single nucleotide polymorphism rs13266634 in the SLC30A8 gene, encoding the secretory granule zinc transporter ZnT8, is associated with type 2 diabetes...
  56. doi Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk
    P Achenbach
    Diabetes Research Institute of Forschergruppe Diabetes e V, Helmholtz Center Munich, Ingolstaedter Landstr 1, 85764, Neuherberg, Germany
    Diabetologia 52:1881-8. 2009
    Our aim was to determine the relationships between autoantibodies to zinc transporter 8 (ZnT8), genotypes of the ZnT8-encoding gene SLC30A8 and type 1 diabetes risk.
  57. pmc Examination of type 2 diabetes loci implicates CDKAL1 as a birth weight gene
    Jianhua Zhao
    Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Diabetes 58:2414-8. 2009
    ..In order to investigate whether type 2 diabetes risk-conferring alleles associate with low birth weight in our Caucasian childhood cohort, we examined the effects of 20 such loci on this trait...
  58. doi Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia
    Johan Rung
    McGill University and Genome Quebec Innovation Centre, Montreal, Canada
    Nat Genet 41:1110-5. 2009
    ....
  59. pmc Zinc transporter 8 antibodies complement GAD and IA-2 antibodies in the identification and characterization of adult-onset autoimmune diabetes: Non Insulin Requiring Autoimmune Diabetes (NIRAD) 4
    Vito Lampasona
    Diabetes Research Institute, San Raffaele Scientific Institute, Milan, Italy
    Diabetes Care 33:104-8. 2010
    b>Zinc transporter 8 (ZnT8) is an islet beta-cell secretory granule membrane protein recently identified as an autoantibody antigen in type 1 diabetes...
  60. pmc PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population
    Cheng Hu
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai, China
    PLoS ONE 4:e7643. 2009
    ..In this study, we attempt to analyze the independent and joint effect of variants from these loci on type 2 diabetes and clinical phenotypes related to glucose metabolism...
  61. pmc New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
    Josee Dupuis
    Department of Biostatistics, Boston University School of Public Health, Massachusetts, USA
    Nat Genet 42:105-16. 2010
    ....
  62. doi Meta-analysis and functional effects of the SLC30A8 rs13266634 polymorphism on isolated human pancreatic islets
    Stephane Cauchi
    CNRS UMR 8090, Institute of Biology, Genomics and Molecular Physiology of Metabolic Diseases, Lille, France
    Mol Genet Metab 100:77-82. 2010
    The C-allele of rs13266634 located in SLC30A8 (ZNT8) has been strongly associated with decreased insulin release and with type 2 diabetes (T2D) susceptibility in some but not all studies...
  63. pmc Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans
    Erik Ingelsson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Diabetes 59:1266-75. 2010
    ..Our findings emphasize the importance of detailed physiological characterization of such loci for improved understanding of pathways associated with alterations in glucose homeostasis and eventually type 2 diabetes...
  64. pmc Kinetics of the post-onset decline in zinc transporter 8 autoantibodies in type 1 diabetic human subjects
    J M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Clin Endocrinol Metab 95:4712-9. 2010
    b>Zinc transporter 8 (ZnT8) is a newly discovered islet autoantigen in human type 1A diabetes (T1D).
  65. doi Correlations between islet autoantibody specificity and the SLC30A8 genotype with HLA-DQB1 and metabolic control in new onset type 1 diabetes
    Caroline Brorsson
    Hagedorn Research Institute and Steno Diabetes Center, Gentofte, Denmark
    Autoimmunity 44:107-14. 2011
    We hypothesised that the correlation between autoantibody specificity for the ZnT8 Arg325Trp isoforms and the type 2 diabetes-associated rs13266634 may affect β-cell function at type 1 diabetes (T1D) onset...
  66. doi The three ZNT8 autoantibody variants together improve the diagnostic sensitivity of childhood and adolescent type 1 diabetes
    C Andersson
    Department of Clinical Sciences, Skåne University Hospital SUS, Lund University, CRC, Malmo, Sweden
    Autoimmunity 44:394-405. 2011
    ....
  67. doi Relationship between ZnT8Ab, the SLC30A8 gene and disease progression in children with newly diagnosed type 1 diabetes
    Lotte B Nielsen
    Department of Paediatrics, Glostrup University Hospital, Glostrup, Denmark
    Autoimmunity 44:616-23. 2011
    Autoantibodies against the newly established autoantigen in type 1 diabetes, zinc transporter 8, ZnT8, are presented as two types, ZnT8RAb and ZnT8WAb...
  68. pmc Antibodies recognizing Mycobacterium avium paratuberculosis epitopes cross-react with the beta-cell antigen ZnT8 in Sardinian type 1 diabetic patients
    Speranza Masala
    Sezione di Microbiologia e Virologia, Dipartimento di Scienze Biomediche, Universita degli Studi di Sassari, Sassari, Italy
    PLoS ONE 6:e26931. 2011
    ..against one of these proteins, namely MAP3865c, which displays a sequence homology with the β-cell protein zinc transporter 8 (ZnT8) could be cross-reactive with ZnT8 epitopes...
  69. pmc Genetic association of zinc transporter 8 (ZnT8) autoantibodies in type 1 diabetes cases
    J M M Howson
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Department of Medical Genetics, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0XY, UK
    Diabetologia 55:1978-84. 2012
    Autoantibodies to zinc transporter 8 (ZnT8A) are associated with risk of type 1 diabetes. Apart from the SLC30A8 gene itself, little is known about the genetic basis of ZnT8A...
  70. pmc Zinc transporter (ZnT)8(186-194) is an immunodominant CD8+ T cell epitope in HLA-A2+ type 1 diabetic patients
    M Scotto
    INSERM, U986, DeAR Lab Avenir, Saint Vincent de Paul Hospital, 82 avenue Denfert Rochereau, 75674 Paris Cedex 14, France
    Diabetologia 55:2026-31. 2012
    Anti-zinc transporter (ZnT)8 autoantibodies are commonly detected in type 1 diabetic patients. We hypothesised that ZnT8 is also recognised by CD8(+) T cells and aimed to identify HLA-A2 (A*02:01)-restricted epitope targets.
  71. pmc ZnT8 is a major CD8+ T cell-recognized autoantigen in pediatric type 1 diabetes
    Emmanuelle Enée
    INSERM, Unité 1013, Paris, France
    Diabetes 61:1779-84. 2012
    ..1) to develop a CD8(+) T-cell interferon-γ ELISpot assay for pediatric patients and 2) to determine whether zinc transporter 8 (ZnT8), a recently described target of autoantibodies in a majority of patients, is also recognized by ..
  72. pmc Zinc transporter 8 autoantibodies and their association with SLC30A8 and HLA-DQ genes differ between immigrant and Swedish patients with newly diagnosed type 1 diabetes in the Better Diabetes Diagnosis study
    Ahmed J Delli
    Department of Clinical Sciences, Diabetes and Celiac Diseases, Lund University, Malmo, Sweden
    Diabetes 61:2556-64. 2012
    We examined whether zinc transporter 8 autoantibodies (ZnT8A; arginine ZnT8-RA, tryptophan ZnT8-WA, and glutamine ZnT8-QA variants) differed between immigrant and Swedish patients due to different polymorphisms of SLC30A8, HLA-DQ, or both...
  73. pmc ZnT8-Specific CD4+ T cells display distinct cytokine expression profiles between type 1 diabetes patients and healthy adults
    Daisuke Chujo
    Baylor Institute for Immunology Research, Dallas, Texas, USA
    PLoS ONE 8:e55595. 2013
    ..Out of ten donors, the Direct assay identified GAD65-specific CD4(+) T cells in three adults and zinc transporter 8 (ZnT8)-specific CD4(+) T cells in five adults...
  74. pmc Zinc transporter 8 and MAP3865c homologous epitopes are recognized at T1D onset in Sardinian children
    Speranza Masala
    Universita degli Studi di Sassari, Dipartimento di Scienze Biomediche, Sezione di Microbiologia e Virologia, Sassari, Sardinia, Italy
    PLoS ONE 8:e63371. 2013
    ..Therefore, we investigated the seroreactivity against epitopes derived from the ZnT8 autoantigen involved in children at T1D onset and their homologous sequences of the MAP3865c protein...
  75. pmc Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies
    Joshua P Lewis
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Diabetes 57:2220-5. 2008
    ..Our objective was to examine the influence of type 2 diabetes genes identified in whole-genome association studies in a large African American case-control population...
  76. pmc SLC30A8 (ZnT8) Polymorphism is Associated with Young Age at Type 1 Diabetes Onset
    Henning Gohlke
    Institute of Epidemiology, Helmholtz Zentrum, Neuherberg, Germany
    Rev Diabet Stud 5:25-7. 2008
    It was recently shown that the major allele of the SLC30A8 (zinc transporter 8, ZnT8) single nucleotide polymorphism (SNP) rs13266634 was associated with type 2 diabetes and with reduced insulin secretion in non-diabetic relatives...
  77. doi A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population
    Caroline Brorsson
    Steno Diabetes Center, Niels Steensensvej 1, DK 2820 Gentofte, Denmark
    Mol Genet Metab 94:386-8. 2008
    ..We genotyped rs13266634 in 3008 cases and controls and 246 families from Denmark. Association to T1D could not be demonstrated...
  78. doi Association between anti-ZnT8 autoantibody specificities and SLC30A8 Arg325Trp variant in Japanese patients with type 1 diabetes
    E Kawasaki
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
    Diabetologia 51:2299-302. 2008
    We analysed the association between humoral autoreactivity to zinc transporter-8 (ZnT8) and the SLC30A8 rs13266634 polymorphism (Arg325Trp), which is located at the most distal loop in the ZnT8 protein.
  79. doi Autoantibodies to insulin, insulinoma-associated antigen-2, and zinc transporter 8 improve the prediction of early insulin requirement in adult-onset autoimmune diabetes
    Eiji Kawasaki
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    J Clin Endocrinol Metab 95:707-13. 2010
    ..The aim of this study was to identify the predictive marker for early insulin requirement in adult-onset autoimmune diabetes in the Japanese populations...
  80. pmc Enterovirus infection and progression from islet autoimmunity to type 1 diabetes: the Diabetes and Autoimmunity Study in the Young (DAISY)
    Lars C Stene
    Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway
    Diabetes 59:3174-80. 2010
    ..To investigate whether enterovirus infections predict progression to type 1 diabetes in genetically predisposed children repeatedly positive for islet autoantibodies...
  81. pmc SLC30A3 responds to glucose- and zinc variations in beta-cells and is critical for insulin production and in vivo glucose-metabolism during beta-cell stress
    Kamille Smidt
    Department of Pharmacology, University of Aarhus, Arhus, Denmark
    PLoS ONE 4:e5684. 2009
    ..Ion transporters of the Slc30A- (ZnT-) family regulate zinc fluxes into sub-cellular compartments. beta-cells depend on zinc for both insulin crystallization and regulation of cell mass...
  82. doi Expression of ZnT and ZIP zinc transporters in the human RPE and their regulation by neurotrophic factors
    Kar Wah Leung
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Invest Ophthalmol Vis Sci 49:1221-31. 2008
    ..The expression and regulation of zinc transporters in the RPE and the toxicity of zinc to these cells were examined...
  83. doi Investigation of transport mechanisms and regulation of intracellular Zn2+ in pancreatic alpha-cells
    Armen V Gyulkhandanyan
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    J Biol Chem 283:10184-97. 2008
    ..We observed that Zip1, Zip10, and Zip14 were the most abundantly expressed Zips and ZnT4, ZnT5, and ZnT8 the dominant ZnTs...
  84. doi Dissecting the nutrigenomics, diabetes, and gastrointestinal disease interface: from risk assessment to health intervention
    Lynnette R Ferguson
    The University of Auckland, Auckland, New Zealand
    OMICS 12:237-44. 2008
    ..An even greater challenge may be in implementing population level changes in diet and behavior to fully exploit the potential of this field...
  85. doi Diabetes-linked zinc transporter ZnT8 is a homodimeric protein expressed by distinct rodent endocrine cell types in the pancreas and other glands
    C Murgia
    INRAN, National Research Institute on Food and Nutrition, Via Ardeatina 546, Roma 00178, Italy
    Nutr Metab Cardiovasc Dis 19:431-9. 2009
    ..b>ZnT8 is a member of the SLC30A family of zinc transporters whose overexpression in cultured pancreatic beta cells leads ..
  86. pmc Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion
    Lynley D Pound
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, TN 37232, USA
    Biochem J 421:371-6. 2009
    ..In summary, Slc30a8 gene deletion is accompanied by a modest impairment in insulin secretion without major alterations in glucose metabolism...
  87. pmc Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice
    K Lemaire
    Gene Expression Unit, Department Molecular Cell Biology, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 106:14872-7. 2009
    ..In this study we assessed the role of the zinc transporter ZnT8 using ZnT8-knockout (ZnT8(-/-)) mice...
  88. pmc ZnT8 autoantibody titers in type 1 diabetes patients decline rapidly after clinical onset
    Fariba Vaziri-Sani
    Department of Clinical Sciences, University Hospital MAS, Lund University, Malmo, Sweden
    Autoimmunity 43:598-606. 2010
    Autoantibodies to the islet-specific zinc transporter isoform 8 (ZnT8) are detected in the majority of type 1 diabetes patients prior to and at clinical diagnosis. The presence of ZnT8Ab after diagnosis has not been investigated...
  89. pmc The pancreatic islet β-cell-enriched transcription factor Pdx-1 regulates Slc30a8 gene transcription through an intronic enhancer
    Lynley D Pound
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Biochem J 433:95-105. 2011
    ....
  90. doi Downregulation of ZnT8 expression in pancreatic β-cells of diabetic mice
    Motoyuki Tamaki
    Department of Medicine, Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Bunkyo ku, Tokyo, Japan
    Islets 1:124-8. 2009
    b>Zinc transporter 8 (ZnT8) has been identified as a β-cell-specific Zinc transporter expressed in insulin-secretory granules...
  91. doi Zinc, zinc transporters and diabetes
    J Rungby
    Department of Endocrinology, Aarhus University Hospital, Tage Hansensgade, DK 8000 Aarhus C, Denmark
    Diabetologia 53:1549-51. 2010
    ..role of zinc in islet function has recently achieved new attention as a consequence of the identification of zinc transporter 8 (ZNT8) in islets, and the association of mutations in the gene for this zinc transporter with glucose ..
  92. pmc Imaging the Beta-cell mass: why and how
    Frantisek Saudek
    Diabetes Center, Institute for Clinical and Experimental Medicine, Videnska 1958 9, 14021 Prague 4, Czech Republic
    Rev Diabet Stud 5:6-12. 2008
    ..In the near future, these promising findings may offer a new way to monitor the beta-cell mass in vivo under disease and therapy conditions so that we can learn more about diabetes pathogenesis and options for disease prevention...
  93. doi New antigenic targets in type 1 diabetes
    Janet M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80045, USA
    Curr Opin Endocrinol Diabetes Obes 15:315-20. 2008
    ..We examine the hypothesis that the cell specificity and cellular localization of this granule membrane protein are significant factors in its contribution to the pathogenesis of these diseases...
  94. doi Association analyses between type 2 diabetes genes and obesity traits in pigs
    Zhi Qiang Du
    Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, Iowa, USA
    Obesity (Silver Spring) 17:323-9. 2009
    ..Further replication of this research in other pig populations should be considered, so that the possibility of utilizing these genetic markers in pig breeding or in animal model research can be explored...
  95. pmc No association of multiple type 2 diabetes loci with type 1 diabetes
    S M Raj
    Cambridge Institute for Medical Research, University of Cambridge, UK
    Diabetologia 52:2109-16. 2009
    ..11 at a false-positive rate of 0.003...
  96. pmc Diabetes genes and prostate cancer in the Atherosclerosis Risk in Communities study
    Tamra E Meyer
    Human Genetics Center and Division of Epidemiology, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 19:558-65. 2010
    ..02; blacks only). The TCF7L2 rs7903146 T allele was inversely associated with PrCa using a dominant genetic model (HR, 0.79; 95% CI, 0.65-0.97). Further knowledge of T2D gene-PrCa mechanisms may improve understanding of PrCa etiology...
  97. pmc Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion
    Martin Heni
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    Diabetes 59:3247-52. 2010
    ..Several single nucleotide polymorphisms (SNPs) in diabetes risk genes reduce glucose- and/or incretin-induced insulin secretion. Here, we investigated interactions between glycemia and such diabetes risk polymorphisms...
  98. doi Think zinc: New roles for zinc in the control of insulin secretion
    Guy A Rutter
    Department of Cell Biology, Imperial College London, UK
    Islets 2:49-50. 2010
    Genome wide association studies have identified the islet-restricted zinc transporter ZnT8 (SLC30A8) as a likely player in the control of insulin secretion and the risk of developing type 2 diabetes...
  99. doi New gene variants alter type 2 diabetes risk predominantly through reduced beta-cell function
    John R B Perry
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
    Curr Opin Clin Nutr Metab Care 11:371-7. 2008
    ..In this study, we focus on explaining the genome-wide approach that has led to most of these discoveries and discuss some of the early insights the new gene loci have provided into the aetiology of type 2 diabetes...
  100. pmc Mouse pancreatic endocrine cell transcriptome defined in the embryonic Ngn3-null mouse
    Kirstine Juhl
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes 57:2755-61. 2008
    ..A further objective was to identify endocrine cell biomarkers, targets of diabetic autoimmunity, and regulatory pathways underlying islet responses to physiological and pathological stimuli...
  101. doi Autoimmune mechanisms in type 1 diabetes
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Autoimmun Rev 7:550-7. 2008
    ....

Research Grants18

  1. Zinc Transporter-8-Specific T Cell Responses in the Prediction of Type 1 Diabetes
    HELENA KRISTIINA REIJONEN; Fiscal Year: 2013
    ..The overall goal of the project is to provide a novel approach to T cel-mediated autoimmunity in T1D which could be applied to prediction. ..
  2. Analysis of diabetogenic human T cell receptors
    Howard W Davidson; Fiscal Year: 2011
    Our demonstration that the islet-specific zinc transporter ZnT8 is a major target of autoantibodies in newly diabetic subjects was arguably the most significant new diabetes biomarker discovered in over a decade...
  3. Christiane S Hampe; Fiscal Year: 2016
    ..Autoantigen-Fc fusion proteins of all four major autoantigens (insulin, GAD65, IA-2, and ZnT8) will be used in this approach...
  4. Malek El Muayed; Fiscal Year: 2016
    ..A widely prevalent inherited variation in the zinc transporter ZnT8 has been shown to be genetic risk factors for developing type 2 diabetes mellitus...
  5. Marian J Rewers; Fiscal Year: 2016
    ..In the last study period we also collaborated with Dr. Hutton who discovered the fourth major islet autoantigen (ZnT8) to define the predictive potential of ZnT8 autoantibodies...
  6. The Environmental Triggers of Diabetes (TEDDY)
    Ake Lernmark; Fiscal Year: 2013
    ..trigger or protect against the development of defined islet autoantibodies (against insulin, GAD65, IA-2 as well as ZnT8) or clinical T1D;B) to assess potential gene-environment interactions affecting development of islet autoimmunity ..
  7. MASSIMO T PIETROPAOLO; Fiscal Year: 2014
    ..of novel biomarkers detecting antibodies directed to IA-2, GAD65 specific epitopes and the newly discovered antigen ZnT8 will further enhance sensitivity and the predictive value of T1DM progression as compared to conventional islet ..
  8. Howard W Davidson; Fiscal Year: 2014
    ..Specific Aim 1: Characterization of spontaneously-arising autoreactive T cells recognizing ZnT8 in NOD mice...
  9. High throughput Point-of-Care assays for diabetes auto-antibody detection
    KUMAR SUBRAMANIAN; Fiscal Year: 2013
    ..homogenous (no wash steps), sensor array specifically for the detection of four insulin auto-antibodies namely, Insulin auto-antibodies (IAA), glutamic acid decarboxylase (GAD65), IA-2 or ICA512 auto-antibodies, and ZnT8 auto-antibodies.
  10. REGULATION OF HEPATIC INSULIN EXTRACTION
    Kenneth S Polonsky; Fiscal Year: 2013
    ....
  11. Fast multiplexed point-of-care diabetes autoantibody detection by homogeneous FRE
    Andrew M Arsham; Fiscal Year: 2013
    ..In particular, auto-antibodies against the proteins insulin, IA-1, GAD65, and ZnT8 are hallmarks of high T1D risk, and the more ICAs are present, the higher the risk...
  12. Sonia Caprio; Fiscal Year: 2014
    ....
  13. T Cell Specificity and Phenotypes in Preclinical Type 1 Diabetes
    HELENA KRISTIINA REIJONEN; Fiscal Year: 2013
    ..Furthermore, improved knowledge of the mechanisms of autoimmune process leading to T1D will contribute to discovery of new therapeutic targets. ..
  14. Recurrence of T1D in Pancreas Transplantation
    George Burke; Fiscal Year: 2009
    ..The knowledge gained should also be relevant to islet cell transplantation and spontaneous disease. ..
  15. Frontiers in Statistical Genetics for NIAMS Researchers
    Hemant Tiwari; Fiscal Year: 2005
    ..abstract_text> ..
  16. International Congress of the Immunology of Diabetes Soc
    George Eisenbarth; Fiscal Year: 2002
    ..Travel grants for young investigators will be chosen by numerical rating of submitted abstracts and additional travel funding will be applied to plenary lectures chosen by the international organizing committee. ..
  17. Phenotype-Genotype Interactions and Type 2 Diabetes
    James Meigs; Fiscal Year: 2005
    ..Results will provide a foundation for future laboratory efforts and will increase understanding of phenotype-genotype interactions in diabetes pathogenesis. ..
  18. Regulation of Celluar Zinc Distribution
    Wolfgang Maret; Fiscal Year: 2004
    ..abstract_text> ..