Akt1

Summary

Gene Symbol: Akt1
Description: thymoma viral proto-oncogene 1
Alias: Akt, LTR-akt, PKB, PKB/Akt, PKBalpha, Rac, RAC-alpha serine/threonine-protein kinase, AKT1 kinase, Akt1m protein, PKB alpha, RAC-PK-alpha, protein kinase B-alpha, proto-oncogene c-AKT, related to A and C kinases, tumor rejection antigen peptide pRLib
Species: mouse
Products:     Akt1

Top Publications

  1. Liu X, Bruxvoort K, Zylstra C, Liu J, Cichowski R, Faugere M, et al. Lifelong accumulation of bone in mice lacking Pten in osteoblasts. Proc Natl Acad Sci U S A. 2007;104:2259-64 pubmed
    ..3-kinase (PI3K), which enhances cell survival and antagonizes apoptosis through activation of Akt/PKB. This process is negatively regulated by the Pten phosphatase, which inhibits the activity of PI3K...
  2. Calautti E, Li J, Saoncella S, Brissette J, Goetinck P. Phosphoinositide 3-kinase signaling to Akt promotes keratinocyte differentiation versus death. J Biol Chem. 2005;280:32856-65 pubmed
    ..We show here that the phosphoinositide 3-kinase (PI3K)/Akt pathway is activated at early stages of mouse keratinocyte differentiation both in culture and in the intact ..
  3. Sumitani S, Goya K, Testa J, Kouhara H, Kasayama S. Akt1 and Akt2 differently regulate muscle creatine kinase and myogenin gene transcription in insulin-induced differentiation of C2C12 myoblasts. Endocrinology. 2002;143:820-8 pubmed
    ..Heterologous expression of Akt1/PKB(alpha) potently suppressed MCK gene transcription without affecting myogenin gene transcription, whereas ..
  4. Watson K, Moorehead R. Loss of Akt1 or Akt2 delays mammary tumor onset and suppresses tumor growth rate in MTB-IGFIR transgenic mice. BMC Cancer. 2013;13:375 pubmed publisher
    ..However, there are three mammalian isoforms of Akt (Akt1, Akt2 and Akt3) and these isoforms regulate distinct physiologic properties within cells...
  5. Humphrey S, Yang G, Yang P, Fazakerley D, Stöckli J, Yang J, et al. Dynamic adipocyte phosphoproteome reveals that Akt directly regulates mTORC2. Cell Metab. 2013;17:1009-20 pubmed publisher
    ..This led to the identification of an Akt substrate, SIN1, a core component of the mTORC2 complex...
  6. Biggs W, Meisenhelder J, Hunter T, Cavenee W, Arden K. Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc Natl Acad Sci U S A. 1999;96:7421-6 pubmed
    ..Protein kinase B (PKB)/Akt, a key mediator of PI3 kinase signal transduction, phosphorylated recombinant FKHR1 in vitro at threonine-24 ..
  7. Xiang B, Zhang G, Liu J, Morris A, Smyth S, Gartner T, et al. A G(i) -independent mechanism mediating Akt phosphorylation in platelets. J Thromb Haemost. 2010;8:2032-41 pubmed publisher
    The serine-threonine kinase Akt plays an important role in regulating platelet activation. Stimulation of platelets with various agonists results in Akt activation as indicated by Akt phosphorylation...
  8. Dillon R, Marcotte R, Hennessy B, Woodgett J, Mills G, Muller W. Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression. Cancer Res. 2009;69:5057-64 pubmed publisher
    ..Our previous studies have shown that coexpression of activated Akt1 with activated ErbB2 or polyoma virus middle T antigen uncoupled from the PI3K pathway (PyVmT Y315/322F) ..
  9. Flores A, Narayanan S, Morse E, Shick H, Yin X, Kidd G, et al. Constitutively active Akt induces enhanced myelination in the CNS. J Neurosci. 2008;28:7174-83 pubmed publisher
    The serine/threonine kinase Akt regulates multiple cellular functions. The current studies identify a new role for Akt in CNS myelination...
  10. Somanath P, Chen J, Byzova T. Akt1 is necessary for the vascular maturation and angiogenesis during cutaneous wound healing. Angiogenesis. 2008;11:277-88 pubmed publisher
    Previous in vivo and in vitro studies have shown that Akt1 serves as a crucial regulator of vascular maturation, extracellular matrix composition, and angiogenesis in tumors...

Detail Information

Publications62

  1. Liu X, Bruxvoort K, Zylstra C, Liu J, Cichowski R, Faugere M, et al. Lifelong accumulation of bone in mice lacking Pten in osteoblasts. Proc Natl Acad Sci U S A. 2007;104:2259-64 pubmed
    ..3-kinase (PI3K), which enhances cell survival and antagonizes apoptosis through activation of Akt/PKB. This process is negatively regulated by the Pten phosphatase, which inhibits the activity of PI3K...
  2. Calautti E, Li J, Saoncella S, Brissette J, Goetinck P. Phosphoinositide 3-kinase signaling to Akt promotes keratinocyte differentiation versus death. J Biol Chem. 2005;280:32856-65 pubmed
    ..We show here that the phosphoinositide 3-kinase (PI3K)/Akt pathway is activated at early stages of mouse keratinocyte differentiation both in culture and in the intact ..
  3. Sumitani S, Goya K, Testa J, Kouhara H, Kasayama S. Akt1 and Akt2 differently regulate muscle creatine kinase and myogenin gene transcription in insulin-induced differentiation of C2C12 myoblasts. Endocrinology. 2002;143:820-8 pubmed
    ..Heterologous expression of Akt1/PKB(alpha) potently suppressed MCK gene transcription without affecting myogenin gene transcription, whereas ..
  4. Watson K, Moorehead R. Loss of Akt1 or Akt2 delays mammary tumor onset and suppresses tumor growth rate in MTB-IGFIR transgenic mice. BMC Cancer. 2013;13:375 pubmed publisher
    ..However, there are three mammalian isoforms of Akt (Akt1, Akt2 and Akt3) and these isoforms regulate distinct physiologic properties within cells...
  5. Humphrey S, Yang G, Yang P, Fazakerley D, Stöckli J, Yang J, et al. Dynamic adipocyte phosphoproteome reveals that Akt directly regulates mTORC2. Cell Metab. 2013;17:1009-20 pubmed publisher
    ..This led to the identification of an Akt substrate, SIN1, a core component of the mTORC2 complex...
  6. Biggs W, Meisenhelder J, Hunter T, Cavenee W, Arden K. Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc Natl Acad Sci U S A. 1999;96:7421-6 pubmed
    ..Protein kinase B (PKB)/Akt, a key mediator of PI3 kinase signal transduction, phosphorylated recombinant FKHR1 in vitro at threonine-24 ..
  7. Xiang B, Zhang G, Liu J, Morris A, Smyth S, Gartner T, et al. A G(i) -independent mechanism mediating Akt phosphorylation in platelets. J Thromb Haemost. 2010;8:2032-41 pubmed publisher
    The serine-threonine kinase Akt plays an important role in regulating platelet activation. Stimulation of platelets with various agonists results in Akt activation as indicated by Akt phosphorylation...
  8. Dillon R, Marcotte R, Hennessy B, Woodgett J, Mills G, Muller W. Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression. Cancer Res. 2009;69:5057-64 pubmed publisher
    ..Our previous studies have shown that coexpression of activated Akt1 with activated ErbB2 or polyoma virus middle T antigen uncoupled from the PI3K pathway (PyVmT Y315/322F) ..
  9. Flores A, Narayanan S, Morse E, Shick H, Yin X, Kidd G, et al. Constitutively active Akt induces enhanced myelination in the CNS. J Neurosci. 2008;28:7174-83 pubmed publisher
    The serine/threonine kinase Akt regulates multiple cellular functions. The current studies identify a new role for Akt in CNS myelination...
  10. Somanath P, Chen J, Byzova T. Akt1 is necessary for the vascular maturation and angiogenesis during cutaneous wound healing. Angiogenesis. 2008;11:277-88 pubmed publisher
    Previous in vivo and in vitro studies have shown that Akt1 serves as a crucial regulator of vascular maturation, extracellular matrix composition, and angiogenesis in tumors...
  11. Peng X, Xu P, Chen M, Hahn Windgassen A, Skeen J, Jacobs J, et al. Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. Genes Dev. 2003;17:1352-65 pubmed
    To elucidate the functions of the serine/threonine kinase Akt/PKB in vivo, we generated mice lacking both akt1 and akt2 genes. Akt1/Akt2 double-knockout (DKO) mice exhibit severe growth deficiency and die shortly after birth...
  12. Laine J, Künstle G, Obata T, Sha M, Noguchi M. The protooncogene TCL1 is an Akt kinase coactivator. Mol Cell. 2000;6:395-407 pubmed
    ..In yeast two-hybrid screening, we found that TCL1 interacts with Akt. All TCL1 isoforms bind to the Akt pleckstrin homology domain...
  13. Cotter L, Ozcelik M, Jacob C, Pereira J, Locher V, Baumann R, et al. Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral nerve overmyelination. Science. 2010;328:1415-8 pubmed publisher
    ..Indeed, the Dlg1 brake is no longer functional in a mouse model of Charcot-Marie-Tooth disease. Therefore, negative regulation of myelination appears to be essential for optimization of nerve conduction velocity and myelin maintenance. ..
  14. Yang Z, Tschopp O, Baudry A, Dummler B, Hynx D, Hemmings B. Physiological functions of protein kinase B/Akt. Biochem Soc Trans. 2004;32:350-4 pubmed
    ..During the past few years, a variety of transgenic and knockout mouse models of PKB (protein kinase B)/Akt have been generated and investigated...
  15. Zhou G, Tucker D, Bae S, Bhatheja K, Birnbaum M, Field J. Opposing roles for Akt1 and Akt2 in Rac/Pak signaling and cell migration. J Biol Chem. 2006;281:36443-53 pubmed
    The Akt/PKB isoforms have different roles in animals, with Akt2 primarily regulating metabolic signaling and Akt1 regulating growth and survival...
  16. Guertin D, Stevens D, Thoreen C, Burds A, Kalaany N, Moffat J, et al. Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev Cell. 2006;11:859-71 pubmed
    ..raptor-mTOR, interaction, and both mLST8 and rictor are required for the hydrophobic motif phosphorylation of Akt/PKB and PKCalpha, but not S6K1...
  17. Peter A, Ko C, Kim M, Hsu N, Ouchi N, Rhie S, et al. Myogenic Akt signaling upregulates the utrophin-glycoprotein complex and promotes sarcolemma stability in muscular dystrophy. Hum Mol Genet. 2009;18:318-27 pubmed publisher
    ..Here we show that myogenic Akt signaling in mouse models of dystrophy promotes increased expression of utrophin, which replaces the function of ..
  18. Juntilla M, Wofford J, Birnbaum M, Rathmell J, Koretzky G. Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation. Proc Natl Acad Sci U S A. 2007;104:12105-10 pubmed
    ..In this study, we explore the role of the two Akt isoforms most highly expressed in the thymus, Akt1 and Akt2, in early T cell development...
  19. Di R, Wu X, Chang Z, Zhao X, Feng Q, Lu S, et al. S6K inhibition renders cardiac protection against myocardial infarction through PDK1 phosphorylation of Akt. Biochem J. 2012;441:199-207 pubmed publisher
    ..Cardiomyocyte-specific deletion of PDK1 (phosphoinositide-dependent kinase 1) and Akt1/3 abolished cardioprotection after MI in the presence of rapamycin administration...
  20. Katsanakis K, Pillay T. Cross-talk between the two divergent insulin signaling pathways is revealed by the protein kinase B (Akt)-mediated phosphorylation of adapter protein APS on serine 588. J Biol Chem. 2005;280:37827-32 pubmed
    ..In this study, we have identified APS as a novel substrate for protein kinase B/Akt using an antibody that exhibits insulin-dependent immunoreactivity with a phosphospecific antibody raised against ..
  21. Khwaja A. Akt is more than just a Bad kinase. Nature. 1999;401:33-4 pubmed
  22. Kunkel M, Ni Q, Tsien R, Zhang J, Newton A. Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter. J Biol Chem. 2005;280:5581-7 pubmed
    The serine/threonine kinase protein kinase B (PKB)/Akt is a critical regulator of insulin signaling, cell survival, and oncogenesis. The activation mechanisms of this key kinase are well characterized...
  23. Beaulieu J, Sotnikova T, Marion S, Lefkowitz R, Gainetdinov R, Caron M. An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. Cell. 2005;122:261-73 pubmed
    ..Here we show that D2 class-receptor-mediated Akt regulation involves the formation of signaling complexes containing beta-arrestin 2, PP2A, and Akt...
  24. Haxhinasto S, Mathis D, Benoist C. The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells. J Exp Med. 2008;205:565-74 pubmed publisher
    ..We identify AKT as a strong repressor of entry into the T reg phenotype in vitro and in vivo...
  25. Schwertfeger K, Richert M, Anderson S. Mammary gland involution is delayed by activated Akt in transgenic mice. Mol Endocrinol. 2001;15:867-81 pubmed
    Activation of the antiapoptotic protein kinase Akt is induced by a number of growth factors that regulate mammary gland development. Akt is expressed during mammary gland development, and expression decreases at the onset of involution...
  26. Maroulakou I, Oemler W, Naber S, Tsichlis P. Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice. Cancer Res. 2007;67:167-77 pubmed
    ..The effects of ablation of Akt1, Akt2, and Akt3 on the induction and the biology of these tumors were dramatically different, with ablation of Akt1 ..
  27. Jones R, Parsons M, Bonnard M, Chan V, Yeh W, Woodgett J, et al. Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo. J Exp Med. 2000;191:1721-34 pubmed
    The serine/threonine kinase protein kinase B (PKB)/Akt mediates cell survival in a variety of systems...
  28. Zhang H, Lipovsky A, Dibble C, Sahin M, Manning B. S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt. Mol Cell. 2006;24:185-97 pubmed
    Feedback inhibition of the PI3K-Akt pathway by the mammalian target of rapamycin complex 1 (mTORC1) has emerged as an important signaling event in tumor syndromes, cancer, and insulin resistance...
  29. Sun J, Phung T, Shiojima I, Felske T, Upalakalin J, Feng D, et al. Microvascular patterning is controlled by fine-tuning the Akt signal. Proc Natl Acad Sci U S A. 2005;102:128-33 pubmed
    We investigated the functions of Akt during vascular development and remodeling by using an inducible endothelial cell-specific driver of the dominant-active myrAkt...
  30. Calmont A, Wandzioch E, Tremblay K, Minowada G, Kaestner K, Martin G, et al. An FGF response pathway that mediates hepatic gene induction in embryonic endoderm cells. Dev Cell. 2006;11:339-48 pubmed
    ..The finding of separate pathways for endoderm tissue specification and growth provides insights for guiding cellular regeneration and stem cell differentiation. ..
  31. Mounir Z, Krishnamoorthy J, Wang S, Papadopoulou B, Campbell S, Muller W, et al. Akt determines cell fate through inhibition of the PERK-eIF2α phosphorylation pathway. Sci Signal. 2011;4:ra62 pubmed publisher
    ..of eIF2α in mammalian cells after either pharmacological inhibition of the phosphoinositide 3-kinase (PI3K)-Akt pathway or genetic or small interfering RNA-mediated ablation of Akt...
  32. Bae G, Lee J, Kim B, Han J, Leem Y, Lee H, et al. Cdo interacts with APPL1 and activates Akt in myoblast differentiation. Mol Biol Cell. 2010;21:2399-411 pubmed publisher
    ..Cdo activates p38MAPK via interaction with two scaffold proteins JLP and Bnip-2 to promote myogenesis. p38MAPK and Akt signaling are required for myogenic differentiation and activation of both signaling pathways is crucial for ..
  33. Larance M, Rowland A, Hoehn K, Humphreys D, Preiss T, Guilhaus M, et al. Global phosphoproteomics identifies a major role for AKT and 14-3-3 in regulating EDC3. Mol Cell Proteomics. 2010;9:682-94 pubmed publisher
    ..and many of the underlying biochemical pathways are regulated via the canonical phosphatidylinositol 3-kinase/AKT pathway...
  34. Izumiya Y, Hopkins T, Morris C, Sato K, Zeng L, Viereck J, et al. Fast/Glycolytic muscle fiber growth reduces fat mass and improves metabolic parameters in obese mice. Cell Metab. 2008;7:159-72 pubmed publisher
    ..we generated a skeletal muscle-specific, conditional transgenic mouse expressing a constitutively active form of Akt1. Transgene activation led to muscle hypertrophy due to the growth of type IIb muscle fibers, which was accompanied ..
  35. Jacobs S, Herman C, Maciver N, Wofford J, Wieman H, Hammen J, et al. Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways. J Immunol. 2008;180:4476-86 pubmed
    ..To further examine the regulation of glucose uptake, we analyzed CD28 activation of Akt, which appeared necessary for maximal glucose uptake of stimulated cells and which we have shown can promote Glut1 ..
  36. Byon C, Javed A, Dai Q, Kappes J, Clemens T, Darley Usmar V, et al. Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling. J Biol Chem. 2008;283:15319-27 pubmed publisher
    ..Inhibition of H2O2-activated AKT signaling blocked VSMC calcification and Runx2 induction concurrently. This blockage did not cause VSMC apoptosis...
  37. Huang J, Dibble C, Matsuzaki M, Manning B. The TSC1-TSC2 complex is required for proper activation of mTOR complex 2. Mol Cell Biol. 2008;28:4104-15 pubmed publisher
    ..mTOR complex 1 (mTORC1) phosphorylates S6K1, while mTORC2 phosphorylates Akt. The TSC1-TSC2 complex is a critical negative regulator of mTORC1...
  38. Yang W, Wang J, Chan C, Lee S, Campos A, Lamothe B, et al. The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science. 2009;325:1134-8 pubmed publisher
    b>Akt signaling plays a central role in many biological functions, such as cell proliferation and apoptosis...
  39. Kane S, Sano H, Liu S, Asara J, Lane W, Garner C, et al. A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain. J Biol Chem. 2002;277:22115-8 pubmed
    ..This method was applied to the identification of substrates for the protein kinase Akt, which specifically phosphorylates the RXRXXS/T motif...
  40. Blaauw B, Mammucari C, Toniolo L, Agatea L, Abraham R, Sandri M, et al. Akt activation prevents the force drop induced by eccentric contractions in dystrophin-deficient skeletal muscle. Hum Mol Genet. 2008;17:3686-96 pubmed publisher
    ..Using inducible transgenesis in mice, we show that when Akt activity is increased the force drop induced by eccentric contractions in mdx mice becomes similar to that of wild-..
  41. Cong L, Chen H, Li Y, Zhou L, McGibbon M, Taylor S, et al. Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells. Mol Endocrinol. 1997;11:1881-90 pubmed
    ..b>Akt is a serine-threonine kinase recently identified as a direct downstream target of phosphatidylinositol 3-kinase...
  42. Chen J, De S, Damron D, Chen W, Hay N, Byzova T. Impaired platelet responses to thrombin and collagen in AKT-1-deficient mice. Blood. 2004;104:1703-10 pubmed
    We investigated the role of Akt-1, one of the major downstream effectors of phosphoinositide 3-kinase (PI3K), in platelet function using mice in which the gene for Akt-1 had been inactivated...
  43. Ganesan L, Wei G, Pengal R, Moldovan L, Moldovan N, Ostrowski M, et al. The serine/threonine kinase Akt Promotes Fc gamma receptor-mediated phagocytosis in murine macrophages through the activation of p70S6 kinase. J Biol Chem. 2004;279:54416-25 pubmed
    ..We and others have previously reported that Akt is phosphorylated in response to Fc gamma R clustering...
  44. Chen C, Stairs D, Boxer R, Belka G, Horseman N, Alvarez J, et al. Autocrine prolactin induced by the Pten-Akt pathway is required for lactation initiation and provides a direct link between the Akt and Stat5 pathways. Genes Dev. 2012;26:2154-68 pubmed publisher
    ..Conditional activation of the PI3K-Akt pathway in the mammary glands of virgin mice by either Akt1 expression or Pten deletion rapidly induced terminal mammary epithelial differentiation accompanied by the ..
  45. Hagiwara A, Cornu M, Cybulski N, Polak P, Betz C, Trapani F, et al. Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c. Cell Metab. 2012;15:725-38 pubmed publisher
    Mammalian target of rapamycin complex 2 (mTORC2) phosphorylates and activates AGC kinase family members, including Akt, SGK1, and PKC, in response to insulin/IGF1. The liver is a key organ in insulin-mediated regulation of metabolism...
  46. Humphrey R, Yu S, Flores L, Jhala U. Glucose regulates steady-state levels of PDX1 via the reciprocal actions of GSK3 and AKT kinases. J Biol Chem. 2010;285:3406-16 pubmed publisher
    ..Glucose-stimulated activation of AKT and inhibition of GSK3 decrease PDX1 phosphorylation and delay degradation...
  47. Fernandez Hernando C, Ackah E, Yu J, Suarez Y, Murata T, Iwakiri Y, et al. Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease. Cell Metab. 2007;6:446-57 pubmed
    ..Here, we show that the genetic ablation of Akt1 on an apolipoprotein E knockout background (ApoE(-/-)Akt1(-/-)) increases aortic lesion expansion and promotes ..
  48. Takahashi A, Kureishi Y, Yang J, Luo Z, Guo K, Mukhopadhyay D, et al. Myogenic Akt signaling regulates blood vessel recruitment during myofiber growth. Mol Cell Biol. 2002;22:4803-14 pubmed
    ..VEGF synthesis were specifically inhibited by the transduction of a dominant-negative mutant of the Akt1 serine-threonine protein kinase...
  49. Kawamura N, Kugimiya F, Oshima Y, Ohba S, Ikeda T, Saito T, et al. Akt1 in osteoblasts and osteoclasts controls bone remodeling. PLoS ONE. 2007;2:e1058 pubmed
    ..This study initially showed that the disruption of Akt1, a major Akt in osteoblasts and osteoclasts, in mice led to low-turnover osteopenia through dysfunctions of both ..
  50. Mao C, Tili E, Dose M, Haks M, Bear S, Maroulakou I, et al. Unequal contribution of Akt isoforms in the double-negative to double-positive thymocyte transition. J Immunol. 2007;178:5443-53 pubmed
    ..pre-TCR signals activate Akt and that pharmacological inhibition of the PI3K/Akt pathway, or combined ablation of Akt1 and Akt2, and to a lesser extent Akt1 and Akt3, interfere with the differentiation of DN3 and the accumulation of ..
  51. Chang R, Wang E. Mouse translation elongation factor eEF1A-2 interacts with Prdx-I to protect cells against apoptotic death induced by oxidative stress. J Cell Biochem. 2007;100:267-78 pubmed
    ..is correlated with reduced activation of caspases 3 and 8, and with increased expression of pro-survival factor Akt. Thus, our results suggest that eEF1A-2 interacts with Prdx-I to functionally provide cells with extraordinary ..
  52. Dogra C, Changotra H, Wergedal J, Kumar A. Regulation of phosphatidylinositol 3-kinase (PI3K)/Akt and nuclear factor-kappa B signaling pathways in dystrophin-deficient skeletal muscle in response to mechanical stretch. J Cell Physiol. 2006;208:575-85 pubmed
    Phosphatidylinositol 3-kinase (PI3K)/Akt and nuclear factor-kappa B (NF-kappaB) signaling pathways play a critical role in mediating survival signals...
  53. Sugatani T, Hruska K. Akt1/Akt2 and mammalian target of rapamycin/Bim play critical roles in osteoclast differentiation and survival, respectively, whereas Akt is dispensable for cell survival in isolated osteoclast precursors. J Biol Chem. 2005;280:3583-9 pubmed
    ..Here we show that Akt1/Akt2 play a critical role in osteoclast differentiation but not cell survival and that mammalian target of ..
  54. Trotman L, Niki M, Dotan Z, Koutcher J, Di Cristofano A, Xiao A, et al. Pten dose dictates cancer progression in the prostate. PLoS Biol. 2003;1:E59 pubmed
    ..The dose of Pten affects key downstream targets such as Akt, p27(Kip1), mTOR, and FOXO3...
  55. Di Poï N, Tan N, Michalik L, Wahli W, Desvergne B. Antiapoptotic role of PPARbeta in keratinocytes via transcriptional control of the Akt1 signaling pathway. Mol Cell. 2002;10:721-33 pubmed
    ..We show herein that PPARbeta modulates Akt1 activation via transcriptional upregulation of ILK and PDK1, revealing a mechanism for the control of Akt1 ..
  56. Pereira J, Benninger Y, Baumann R, Gonçalves A, Ozcelik M, Thurnherr T, et al. Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system. J Cell Biol. 2009;185:147-61 pubmed publisher
    ..ILK also facilitates axon remyelination, likely by promoting the activation of downstream molecules such as AKT/protein kinase B.
  57. Iliopoulos D, Polytarchou C, Hatziapostolou M, Kottakis F, Maroulakou I, Struhl K, et al. MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells. Sci Signal. 2009;2:ra62 pubmed publisher
    ..We expressed each isoform individually in an Akt1(-/-)/Akt2(-/-)/Akt3(-/-) cell line...
  58. Xin X, Chen S, Khan Z, Chakrabarti S. Akt activation and augmented fibronectin production in hyperhexosemia. Am J Physiol Endocrinol Metab. 2007;293:E1036-44 pubmed
    ..We studied Akt1/PKBalpha knockout mice and wild-type control littermates...
  59. Boxer R, Stairs D, Dugan K, Notarfrancesco K, Portocarrero C, Keister B, et al. Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation. Cell Metab. 2006;4:475-90 pubmed
    ..By evaluating mice bearing targeted deletions in Akt1 or Akt2, we demonstrate that Akt1 is specifically required for lactating mice to synthesize sufficient quantities ..
  60. Troutman T, Hu W, Fulenchek S, Yamazaki T, Kurosaki T, Bazan J, et al. Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt. Proc Natl Acad Sci U S A. 2012;109:273-8 pubmed publisher
    ..Our results demonstrate that BCAP is a unique TIR domain-containing TLR signaling adapter crucial for linking TLRs to PI3K activation and regulating the inflammatory response. ..
  61. Tan S, Ng Y, Meoli C, Kumar A, Khoo P, Fazakerley D, et al. Amplification and demultiplexing in insulin-regulated Akt protein kinase pathway in adipocytes. J Biol Chem. 2012;287:6128-38 pubmed publisher
    b>Akt plays a major role in insulin regulation of metabolism in muscle, fat, and liver. Here, we show that in 3T3-L1 adipocytes, Akt operates optimally over a limited dynamic range...
  62. DeBosch B, Treskov I, Lupu T, Weinheimer C, Kovacs A, Courtois M, et al. Akt1 is required for physiological cardiac growth. Circulation. 2006;113:2097-104 pubmed
    ..that includes the protein kinase Akt regulates the growth and survival of many cell types, but the precise role of Akt1 in either form of cardiac hypertrophy is unknown...