Amelx

Summary

Gene Symbol: Amelx
Description: amelogenin, X-linked
Alias: ALGN, AMGL, AMGX, Amel, Amg, LRAP, Rgsc888, amelogenin, X isoform, amelogenin X chromosome, enamel matrix protein, leucine-rich amelogenin peptide
Species: mouse

Top Publications

  1. ncbi Transgenic mice that express normal and mutated amelogenins
    C W Gibson
    Department of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, 240 S 40th Street, Philadelphia, PA 19104 6030, USA
    J Dent Res 86:331-5. 2007
  2. ncbi A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2
    J Collignon
    Laboratory of Developmental Genetics, MRC National Institute for Medical Research, London, UK
    Development 122:509-20. 1996
  3. ncbi Alternative splicing of the mouse amelogenin primary RNA transcript contributes to amelogenin heterogeneity
    E C Lau
    University of Southern California, Center for Craniofacial Molecular Biology, Los Angeles 90033
    Biochem Biophys Res Commun 188:1253-60. 1992
  4. ncbi Human and mouse amelogenin gene loci are on the sex chromosomes
    E C Lau
    Laboratory for Developmental Biology, University of Southern California, School of Dentistry, Los Angeles 90089
    Genomics 4:162-8. 1989
  5. ncbi Alternative splicing of the mouse amelogenin primary RNA transcript
    J P Simmer
    University of Texas School of Dentistry, Department of Pediatric Dentistry, San Antonio 78284 7888
    Calcif Tissue Int 55:302-10. 1994
  6. ncbi Early determination and permissive expression of amelogenin transcription during mouse mandibular first molar development
    R I Couwenhoven
    Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry, Los Angeles 90033
    Dev Biol 164:290-9. 1994
  7. ncbi Molecular cloning and DNA sequence of rat amelogenin and a comparative analysis of mammalian amelogenin protein sequence divergence
    W A Bonass
    Division of Oral Biology, Leeds Dental Institute, University of Leeds, U K
    Biochem Biophys Res Commun 198:755-63. 1994
  8. ncbi Antisense inhibition of AMEL translation demonstrates supramolecular controls for enamel HAP crystal growth during embryonic mouse molar development
    T Diekwisch
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles 90033
    Development 117:471-82. 1993
  9. ncbi Immunohistochemical similarities and differences between amelogenin and tuftelin gene products during tooth development
    T G Diekwisch
    Baylor College of Dentistry, Department for Biomedical Sciences, Dallas, Texas 75246, USA
    J Histochem Cytochem 45:859-66. 1997
  10. ncbi Sonic hedgehog regulates growth and morphogenesis of the tooth
    H R Dassule
    Department of Molecular and Cellular Biology, The Biolabs, Divinity Avenue, Cambridge, MA 02138, USA
    Development 127:4775-85. 2000

Research Grants

  1. REGULATION OF EXPRESSION OF THE AMELOGENIN GENES
    CAROLYN GIBSON; Fiscal Year: 2001
  2. The Impact of Fluoride on the Rho Signaling Pathway and the Actin Cytoskeleton
    CAROLYN GIBSON; Fiscal Year: 2008
  3. LECTIN-LIKE PROPERTIES OF AMELOGENINS
    RAJESWARI RAVINDRANATH; Fiscal Year: 2004
  4. MMP-20 AND MMP-20 DOMAIN FUNCTION IN FORMING ENAMEL
    John Bartlett; Fiscal Year: 2006
  5. DETERMINANTS OF ROOT RESORPTION DUE TO ORTHODONTIC MOVEMENT
    Margarita Zeichner David; Fiscal Year: 2005
  6. CEMENTOGENESIS: ROLE OF HERTWIG'S EPITHELIAL ROOT SHEATH
    Margarita Zeichner David; Fiscal Year: 2006
  7. Eda/Edar Regulation of Embryonic SMG Development
    Tina Jaskoll; Fiscal Year: 2007
  8. TISSUE ENGINEERING FOR PERIODONTIUM REPAIR
    Margarita Zeichner David; Fiscal Year: 2003
  9. THE GENOTYPE AND PHENOTYPE AMELOGENESIS IMPERFECTA
    John Wright; Fiscal Year: 2004
  10. MODIFYING GENE DETERMINANTS OF TOOTH AND BONE PHENOTYPES
    John Wright; Fiscal Year: 2007

Scientific Experts

Detail Information

Publications120 found, 100 shown here

  1. ncbi Transgenic mice that express normal and mutated amelogenins
    C W Gibson
    Department of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, 240 S 40th Street, Philadelphia, PA 19104 6030, USA
    J Dent Res 86:331-5. 2007
    ..mice with expression of M180, or M180 with the proline-to-threonine (P70T) mutation, under control of the Amelx gene regulatory regions...
  2. ncbi A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2
    J Collignon
    Laboratory of Developmental Genetics, MRC National Institute for Medical Research, London, UK
    Development 122:509-20. 1996
    ..However our findings imply that if this is true, then Sry has undergone concomitant changes resulting in loss of CNS expression and altered DNA-binding properties...
  3. ncbi Alternative splicing of the mouse amelogenin primary RNA transcript contributes to amelogenin heterogeneity
    E C Lau
    University of Southern California, Center for Craniofacial Molecular Biology, Los Angeles 90033
    Biochem Biophys Res Commun 188:1253-60. 1992
    ..Four additional cDNAs derived from alternatively spliced amelogenin mRNAs have been cloned and characterized. The five transcripts encode amelogenins 180, 156, 141, 74, and 59 amino acids in length...
  4. ncbi Human and mouse amelogenin gene loci are on the sex chromosomes
    E C Lau
    Laboratory for Developmental Biology, University of Southern California, School of Dentistry, Los Angeles 90089
    Genomics 4:162-8. 1989
    ..We have determined the chromosomal locations for the human and mouse amelogenin (AMEL) loci using Southern blot analyses of DNA from human, mouse, or somatic cell hybrids by hybridization to a ..
  5. ncbi Alternative splicing of the mouse amelogenin primary RNA transcript
    J P Simmer
    University of Texas School of Dentistry, Department of Pediatric Dentistry, San Antonio 78284 7888
    Calcif Tissue Int 55:302-10. 1994
    ..Antibodies were raised to synthetic exon 4-encoded polypeptides and used to immunostain Western transfers and histologic tooth sections...
  6. ncbi Early determination and permissive expression of amelogenin transcription during mouse mandibular first molar development
    R I Couwenhoven
    Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry, Los Angeles 90033
    Dev Biol 164:290-9. 1994
    ....
  7. ncbi Molecular cloning and DNA sequence of rat amelogenin and a comparative analysis of mammalian amelogenin protein sequence divergence
    W A Bonass
    Division of Oral Biology, Leeds Dental Institute, University of Leeds, U K
    Biochem Biophys Res Commun 198:755-63. 1994
    ....
  8. ncbi Antisense inhibition of AMEL translation demonstrates supramolecular controls for enamel HAP crystal growth during embryonic mouse molar development
    T Diekwisch
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles 90033
    Development 117:471-82. 1993
    ..We conclude that secreted extracellular proteins form a supramolecular aggregate, which controls both the orientation and dimensions of enamel crystal formation during tooth development...
  9. ncbi Immunohistochemical similarities and differences between amelogenin and tuftelin gene products during tooth development
    T G Diekwisch
    Baylor College of Dentistry, Department for Biomedical Sciences, Dallas, Texas 75246, USA
    J Histochem Cytochem 45:859-66. 1997
    ..The spatial differences in the distribution of amelogenin and tuftelin as observed in this study may be interpreted as an indication of functional differences between both proteins during early enamel biomineralization...
  10. ncbi Sonic hedgehog regulates growth and morphogenesis of the tooth
    H R Dassule
    Department of Molecular and Cellular Biology, The Biolabs, Divinity Avenue, Cambridge, MA 02138, USA
    Development 127:4775-85. 2000
    ..These studies demonstrate that Shh regulates growth and determines the shape of the tooth. However, Shh signaling is not essential for differentiation of ameloblasts or odontoblasts...
  11. ncbi Amelogenin-deficient mice display an amelogenesis imperfecta phenotype
    C W Gibson
    Department of Anatomy and Histology, University of Pennsylvania School of Dental Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 276:31871-5. 2001
    ..These null mice will be useful for understanding the functions of amelogenin proteins during enamel formation and for developing therapeutic approaches for treating this developmental defect that affects the enamel...
  12. ncbi Amelogenin interacts with cytokeratin-5 in ameloblasts during enamel growth
    Rajeswari M H Ravindranath
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles 90033 1004, USA
    J Biol Chem 278:20293-302. 2003
    ..Upon secretion of amelogenin, K5 pairs with K14. Pairing of K5 and K14 commences on day 3 and ends on day 9. The pairing of K5 and K14 marks the end of secretion of amelogenin...
  13. ncbi Expression of amelogenin in odontoblasts
    P Papagerakis
    Department of Pediatric Dentistry, Dental School, University of Texas Health Science Center at San Antonio, San Antonio, TX 78284, USA
    Bone 32:228-40. 2003
    ..This developmental regulated expression pattern is enhanced under vitamin-D-deficiency status and in a broader context may play an important role during ameloblast and odontoblast differentiation and function...
  14. ncbi The receptor activator of nuclear factor-kappa B ligand-mediated osteoclastogenic pathway is elevated in amelogenin-null mice
    Junko Hatakeyama
    Functional Genomics Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:35743-8. 2003
    ..time the expression of two alternate splice forms of amelogenins, M180 and the leucine-rich amelogenin peptide (LRAP), in the periodontal region of mouse tooth roots...
  15. ncbi Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signaling and ameloblast differentiation
    Xiu Ping Wang
    Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, PO Box 56, University of Helsinki, FIN 00014 Helsinki, Finland
    Dev Cell 7:719-30. 2004
    ....
  16. ncbi Reuptake of extracellular amelogenin by dental epithelial cells results in increased levels of amelogenin mRNA through enhanced mRNA stabilization
    Liming Xu
    Biomaterials Center, National Institute for Materials Science, 1 1 Namiki, Tsukuba, Ibaraki 305 0044, Japan
    J Biol Chem 281:2257-62. 2006
    ..Here we speculated that during differentiation, dental epithelial cells utilize a unique mechanism for increasing the production of amelogenin, the reuptake of secreted amelogenin...
  17. ncbi A developmental comparison of matrix metalloproteinase-20 and amelogenin null mouse enamel
    John D Bartlett
    Department of Cytokine Biology, Forsyth Institute, Boston, MA 02115, USA
    Eur J Oral Sci 114:18-23; discussion 39-41, 379. 2006
    ..Both genes are essential for the generation of full-thickness enamel containing the characteristic decussating prism pattern...
  18. ncbi Amelogenin, a major structural protein in mineralizing enamel, is also expressed in soft tissues: brain and cells of the hematopoietic system
    Dan Deutsch
    Dental Research Laboratory, Institute of Dental Sciences, Hebrew University Hadassah, Faculty of Dental Medicine, Jerusalem, Israel, and Institute of Anatomy, Charite Medical Center, Berlin, Germany
    Eur J Oral Sci 114:183-9; discussion 201-2, 381. 2006
    ..Several different potential functions of amelogenin are discussed...
  19. ncbi Comparison of body weight and gene expression in amelogenin null and wild-type mice
    Yong Li
    Department of Anatomy and Cell Biology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA
    Eur J Oral Sci 114:190-3; discussion 201-2, 381. 2006
    Amelogenin (AmelX) null mice develop hypomineralized enamel lacking normal prism structure, but are healthy and fertile...
  20. ncbi Amelogenin and ameloblastin show growth-factor like activity in periodontal ligament cells
    Maggie Zeichner-David
    Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry, Los Angeles, CA 90033, USA
    Eur J Oral Sci 114:244-53; discussion 254-6, 381-2. 2006
    ..Amelogenin also induced the expression of bone sialoprotein. These results suggest that amelogenin, as well as ameloblastin, might have some 'growth factor' activity during periodontium development and regeneration...
  21. ncbi Changes in gene-expression during development of the murine molar tooth germ
    Harald Osmundsen
    Department of Oral Biology, University of Oslo, Box 1052 Blindern, 0316 Oslo, Norway
    Arch Oral Biol 52:803-13. 2007
    ..Such data is therefore useful in directing attention towards genes, or cellular activities, which likely are worthy of further studies as regards their involvement in odontogenesis...
  22. pmc Determination of protein regions responsible for interactions of amelogenin with CD63 and LAMP1
    Yanming Zou
    University of Southern California School of Dentistry, Center for Craniofacial Molecular Biology, 2250 Alcazar Street, CSA Room 103, Los Angeles, CA 90033 1004, USA
    Biochem J 408:347-54. 2007
    The enamel matrix protein amelogenin is secreted by ameloblasts into the extracellular space to guide the formation of highly ordered hydroxyapatite mineral crystallites, and, subsequently, is almost completely removed during mineral ..
  23. pmc An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors
    Ophir D Klein
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, CA 94143 2711, USA
    Development 135:377-85. 2008
    ..These data reveal that the generation of differentiated progeny from a particular stem cell population can be differently regulated in the embryo and adult...
  24. doi Amelogenin binds to both heparan sulfate and bone morphogenetic protein 2 and pharmacologically suppresses the effect of noggin
    Kan Saito
    Division of Pediatric Dentistry, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8588, Japan
    Bone 43:371-6. 2008
    ..Together with the above findings, our findings suggest that the BMP2/4 contaminated during the purification process of EMD because of the avidity of amelogenin plays an important role in signaling pathway of calcification...
  25. pmc The cell adhesion molecule nectin-1 is critical for normal enamel formation in mice
    Martin J Barron
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Hum Mol Genet 17:3509-20. 2008
    ..Importantly, our results show that integrity of the SI-ameloblast interface is essential for normal enamel mineralization...
  26. pmc Human and mouse enamel phenotypes resulting from mutation or altered expression of AMEL, ENAM, MMP20 and KLK4
    J Timothy Wright
    Department of Pediatric Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA
    Cells Tissues Organs 189:224-9. 2009
    Amelogenesis imperfecta (AI) is caused by AMEL, ENAM, MMP20 and KLK4 gene mutations. Mice lacking expression of the AmelX, Enam and Mmp20 genes have been generated...
  27. pmc A solution NMR investigation into the early events of amelogenin nanosphere self-assembly initiated with sodium chloride or calcium chloride
    Garry W Buchko
    Pacific Northwest National Laboratory, Richland, Washington, USA
    Biochemistry 47:13215-22. 2008
    ..1 nm in the absence of salt to 10 nm in the presence of salt. These results suggest a possible stepwise interaction mechanism, starting with the N-terminus and followed by the C-terminus, leading to amelogenin nanosphere assembly...
  28. doi Amelogenin in cranio-facial development: the tooth as a model to study the role of amelogenin during embryogenesis
    Yael Gruenbaum-Cohen
    Dental Research Laboratory, Institute of Dental Sciences, Hebrew University, Hadassah, Faculty of Dental Medicine, Jerusalem, Israel
    J Exp Zool B Mol Dev Evol 312:445-57. 2009
    ..The present results indicate that amelogenin has an important role in many tissues of the cranio-facial complex during mouse embryonic development and differentiation, and might be a multifunctional protein...
  29. pmc Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis
    Olga Golonzhka
    Department of Pharmaceutical Sciences, Oregon State University, Corvallis, OR 97331, USA
    Proc Natl Acad Sci U S A 106:4278-83. 2009
    ..These results suggest that Ctip2 functions as a critical regulator of epithelial cell fate and differentiation during tooth morphogenesis...
  30. pmc Synergistic roles of amelogenin and ameloblastin
    J Hatakeyama
    Functional Genomics Section, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Dent Res 88:318-22. 2009
    ..To identify their synergistic roles in enamel development, we generated Amel X(-/-)/Ambn(-/-) mice. These mice showed additional enamel defects in comparison with Amel X(-/-) or Ambn(-/-) mice...
  31. ncbi Putative signaling action of amelogenin utilizes the Wnt/beta-catenin pathway
    M Matsuzawa
    Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Periodontal Res 44:289-96. 2009
    ..In this article we report the successful purification of a recombinant mouse amelogenin protein and demonstrate that it has signaling activity in isolated mouse calvarial cells and human periodontal ligament cells...
  32. pmc The amelogenin C-terminus is required for enamel development
    M K Pugach
    Department of Anatomy and Cell Biology, University of Pennsylvania School of Dental Medicine, Philadelphia, 19104 6030, USA
    J Dent Res 89:165-9. 2010
    ..Because transgenic full-length amelogenin partially rescues both density and volume of KO molar enamel, it was concluded that the amelogenin C-terminus is essential for proper enamel density, volume, and organization...
  33. pmc A mutation in the mouse Amelx tri-tyrosyl domain results in impaired secretion of amelogenin and phenocopies human X-linked amelogenesis imperfecta
    Martin J Barron
    Faculty of Life Sciences and School of Dentistry, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK
    Hum Mol Genet 19:1230-47. 2010
    ..Using a multi-disciplinary approach, we describe here a mis-sense mutation in the mouse Amelx gene resulting in a Y --> H substitution in the tri-tyrosyl domain of the enamel extracellular matrix protein ..
  34. pmc BmprIa is required in mesenchymal tissue and has limited redundant function with BmprIb in tooth and palate development
    Lu Li
    Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA
    Dev Biol 349:451-61. 2011
    ..Our results demonstrate an essential role for BmprIa in the mesenchymal component and a limited functional redundancy between BmprIa and BmprIb in a tissue-specific manner during tooth and palate development...
  35. pmc Phenotype-genotype correlations in mouse models of amelogenesis imperfecta caused by Amelx and Enam mutations
    Thomas Liam Coxon
    School of Dentistry, Faculty of Health and Life Sciences, Dental Hospital, Liverpool, UK
    Cells Tissues Organs 196:420-30. 2012
    Mutations in human and in mouse orthologous genes Amelx and Enam result in a diverse range of enamel defects...
  36. pmc Gene Expression Profiling during Murine Tooth Development
    Maria A Dos Santos Silva Landin
    Department of Oral Biology, University of Oslo Oslo, Norway
    Front Genet 3:139. 2012
    The aim of this study was to describe the expression of genes, including ameloblastin (Ambn), amelogenin X chromosome (Amelx), and enamelin (Enam) during early (pre-secretory) tooth development...
  37. pmc Expression and function of enamel-related gene products in calvarial development
    P Atsawasuwan
    Brodie Laboratory for Craniofacial Genetics, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Dent Res 92:622-8. 2013
    ..Developing skulls from both Amel- and Ambn-deficient animals were approximately 15% shorter when compared with those of wild-type controls, and ..
  38. pmc Leucine rich amelogenin peptide alters ameloblast differentiation in vivo
    Jonathan Stahl
    Department of Orofacial Sciences, School of Dentistry, University of California, San Francisco, CA, USA
    Matrix Biol 32:432-42. 2013
    ..Here we examined the role of the 59 amino acid alternatively spliced amelogenin known as leucine rich amelogenin peptide (LRAP) on enamel formation, using transgenic murine models in which LRAP overexpression is driven by ..
  39. ncbi Cloning, characterization, and heterologous expression of exon-4-containing amelogenin mRNAs
    C C Hu
    University of Texas School of Dentistry, Health Science Center at San Antonio, Department of Pediatric Dentistry 78284 7888, USA
    J Dent Res 76:641-7. 1997
    ..The exon-4-containing amelogenin isoforms were heterologously expressed in E. coli by means of the pET11 expression system (Novagen, Madison, WI)...
  40. pmc Partial rescue of the amelogenin null dental enamel phenotype
    Yong Li
    Department of Anatomy and Cell Biology, University of Pennsylvania School of Dental Medicine, 240 S 40th Street, Philadelphia, PA 19104 6030, USA
    J Biol Chem 283:15056-62. 2008
    The amelogenins are the most abundant secreted proteins in developing dental enamel. Enamel from amelogenin (Amelx) null mice is hypoplastic and disorganized, similar to that observed in X-linked forms of the human enamel defect ..
  41. pmc Enamel-free teeth: Tbx1 deletion affects amelogenesis in rodent incisors
    Javier Caton
    Department of Craniofacial Development, King s College London, GKT Dental Institute, London SE1 9RT, UK
    Dev Biol 328:493-505. 2009
    ..These results demonstrate that Tbx1 is essential for the maintenance of ameloblast progenitor cells in rodent incisors and that its deletion results in the absence of enamel formation...
  42. pmc Amelogenin genes and sexual dimorphism of teeth in humans and mice
    S R Blecher
    Am J Hum Genet 51:1451-2. 1992
  43. ncbi Determination of a molecular map position for Hyp using a new interspecific backcross produced by in vitro fertilization
    G Kay
    Section of Comparative Biology, MRC Clinical Research Centre, Harrow, Middlesex, United Kingdom
    Genomics 11:651-7. 1991
    ..of each of 241 backcross progeny has been established using the X-linked anchor loci Otc, Hprt, Dmd, Pgk-1, and Amg and the additional probes DXSmh43 and Cbx-rs1...
  44. ncbi Chromosomal assignment of genes involved in glycosylphosphatidylinositol anchor biosynthesis: implications for the pathogenesis of paroxysmal nocturnal hemoglobinuria
    R E Ware
    Department of Pediatrics, Duke University Medical Center, Durham, NC
    Blood 83:3753-7. 1994
    ..The location of Pigf and Pigh suggests that mutations on both alleles of these autosomal genes would be necessary to produce PNH. This helps to explain the predominant class A defect in PNH...
  45. ncbi Expression of matrix proteins during the development of mineralized tissues
    B Sommer
    Laboratory for Oral Cell Biology, Dental School, Bern, Switzerland
    Bone 19:371-80. 1996
    ..The expression patterns of the transcripts encoding the bone matrix proteins suggest different biological roles depending on the time and site of expression...
  46. ncbi Characterization of Cxorf5 (71-7A), a novel human cDNA mapping to Xp22 and encoding a protein containing coiled-coil alpha-helical domains
    L de Conciliis
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Genomics 51:243-50. 1998
    ....
  47. ncbi Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution
    I E Ehrmann
    Transplantation Biology Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    Hum Mol Genet 7:1725-37. 1998
    ..These results shed light on the evolution of X-Y homologous genes...
  48. ncbi Amelogenin: a potential regulator of cementum-associated genes
    Hema L Viswanathan
    Department of Periodontics, Prevention and Geriatrics, University of Michigan School of Dentistry, Ann Arbor, MI, USA
    J Periodontol 74:1423-31. 2003
    ..Amelogenins have been reported to induce expression of a mineralized tissue-specific marker, bone sialoprotein (BSP), indicating that epithelial products can regulate the activity of mesenchyme-derived cells...
  49. pmc Amelogenin supramolecular assembly in nanospheres defined by a complex helix-coil-PPII helix 3D-structure
    Xu Zhang
    Brodie Laboratory for Craniofacial Genetics, College of Dentistry, University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 6:e24952. 2011
    ..spectra of the full-length amelogenin central domain region completely overlapped with spectra of the monomeric Amel-M fragment, suggesting that the central amelogenin coil region did not involve in assembly, even in assembled ..
  50. pmc A pituitary homeobox 2 (Pitx2):microRNA-200a-3p:β-catenin pathway converts mesenchymal cells to amelogenin-expressing dental epithelial cells
    Thad Sharp
    From the Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242
    J Biol Chem 289:27327-41. 2014
    ..This pathway and reprogramming can be used to reprogram mesenchymal or oral epithelial cells to dental epithelial (ameloblast) cells, which can be used in tissue repair and regeneration studies. ..
  51. pmc Weaker dental enamel explains dental decay
    Alexandre R Vieira
    Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 10:e0124236. 2015
    ..Mechanical tests showed that dental enamel developed with less amelogenin is "weaker" while the dental enamel of animals over-expressing amelogenin appears to be more resistant to acid dissolution. ..
  52. pmc PERP regulates enamel formation via effects on cell-cell adhesion and gene expression
    Andrew H Jheon
    Department of Orofacial Sciences and Program in Craniofacial and Mesenchymal Biology, University of California, San Francisco, CA 94143, USA
    J Cell Sci 124:745-54. 2011
    ..Together, our data show that PERP is necessary for the integrity of the ameloblast-SI interface and that a lack of Perp causes downregulation of genes that are required for proper enamel formation...
  53. pmc Phosphorylation and ionic strength alter the LRAP-HAP interface in the N-terminus
    Jun Xia Lu
    Pacific Northwest National Laboratory, Richland, WA 99354, USA
    Biochemistry 52:2196-205. 2013
    ..that two of these changing conditions, pH and ionic strength, have in modulating the interaction of the amelogenin, LRAP, with hydroxyapatite (HAP)...
  54. pmc The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation
    Huojun Cao
    Department of Anatomy and Cell Biology, The University of Iowa, Iowa City, IA 52242, USA
    Development 140:3348-59. 2013
    ..Our in vivo and in vitro studies reveal a multistep transcriptional program involving the Pitx2:miR-200c/141:noggin regulatory pathway that is important in epithelial cell differentiation and tooth development. ..
  55. ncbi The X-Y homologous gene amelogenin maps to the short arms of both the X and Y chromosomes and is highly conserved in primates
    D M Bailey
    Department of Pathology, Cambridge University, United Kingdom
    Genomics 14:203-5. 1992
  56. ncbi Maintenance of amelogenin gene expression by transformed epithelial cells of mouse enamel organ
    L S Chen
    Center for Craniofacial Molecular Biology, University of Southern California, School of Dentistry, Los Angeles 90033
    Arch Oral Biol 37:771-8. 1992
    ....
  57. pmc Telomere-related markers for the pseudoautosomal region of the mouse genome
    E M Eicher
    Jackson Laboratory, Bar Harbor, ME 04609
    Proc Natl Acad Sci U S A 89:2160-4. 1992
    ..Both fragments were closely linked to each other and located on the X chromosome distal to amelogenin (Amg)--in agreement with X or PA linkage...
  58. ncbi A candidate spermatogenesis gene on the mouse Y chromosome is homologous to ubiquitin-activating enzyme E1
    G F Kay
    Section of Comparative Biology, MRC Clinical Research Centre, Harrow, UK
    Nature 354:486-9. 1991
    ..These Y-linked genes may form part of a coregulated group of genes which function during spermatogenesis...
  59. ncbi Of mice and men: anatomy of the amelogenin gene
    M L Snead
    School of Dentistry, University of Southern California, Los Angeles 90089 0191
    Connect Tissue Res 22:101-9. 1989
    ..The mouse genome has been shown to contain only one copy of the amelogenin (AMEL) gene which is not amplified or rearranged during ameloblast determination...
  60. ncbi DNA sequence for cloned cDNA for murine amelogenin reveal the amino acid sequence for enamel-specific protein
    M L Snead
    Biochem Biophys Res Commun 129:812-8. 1985
    ..However, an additional 10-residues were found at the carboxy terminus of the murine amelogenin. This is the most complete sequence database for amelogenin peptides and the only DNA sequence for enamel specific genes...
  61. ncbi The locus for pyruvate dehydrogenase E1 alpha subunit (Pdha1) lies between Plp and Amg on the mouse X chromosome
    H J Blair
    Genetics Division, MRC Radiobiology Unit, Didcot, Oxon, UK
    Mamm Genome 4:230-3. 1993
  62. ncbi Cloning and characterization of the mouse PIG-A gene
    J Yu
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Biochim Biophys Acta 1255:344-50. 1995
    ..Spretus backcross DNA localized the mouse PIG-A gene near the telomeric end of the mouse X chromosome. The isolation of the mouse PIG-A gene opens the possibility for the development of a mouse model of PNH...
  63. ncbi Amelogenin signal peptide mutation: correlation between mutations in the amelogenin gene (AMGX) and manifestations of X-linked amelogenesis imperfecta
    M Lagerstrom-Fermer
    Department of Medical Genetics, Biomedical Center, University of Uppsala, Sweden
    Genomics 26:159-62. 1995
    ..In this study we describe a 9-bp deletion in exon 2 of the amelogenin gene (AMGX) causing X-linked hypoplastic amelogenesis imperfecta, a disease characterized by defective enamel...
  64. ncbi Mapping of the X-linked cataract (Xcat) mutation, the gene implicated in the Nance Horan syndrome, on the mouse X chromosome
    D Stambolian
    Department of Ophthalmology, Scheie Eye Institute, School of Medicine, University of Pennsylvania, Philadelphia 19104
    Genomics 22:377-80. 1994
    ....
  65. ncbi Analysis of CAG trinucleotide repeats from mouse cDNA sequences
    C Abbott
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK
    Ann Hum Genet 58:87-94. 1994
    ..Sinh1b maps very distally on the X chromosome, and Chat maps to chromosome 14...
  66. pmc Structural variation of the pseudoautosomal region between and within inbred mouse strains
    D Kipling
    Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom
    Proc Natl Acad Sci U S A 93:171-5. 1996
    ..Two pseudoautosomal probes can also hybridize to the distal telomeres of chromosomes 9 and 13, and all three telomeres contain DXYMov15. The similarity between these telomeres may reflect ancestral telomere-telomere exchange...
  67. ncbi Structure and location of the murine adrenoleukodystrophy gene
    M A Kennedy
    Cytogenetic and Molecular Oncology Unit, Christchurch School of Medicine, New Zealand
    Genomics 32:395-400. 1996
    ..We found evidence for other sequences in the mouse genome related to the 3' end of Aldgh. This study paves the way for the construction of gene-targeting plasmids that may be used to develop an animal model of ALD...
  68. ncbi Isolation and characterization of a mouse homolog of the X-linked ocular albinism (OA1) gene
    J M Newton
    Department of Pediatrics, Stanford University School of Medicine, California 94305 5428, USA
    Genomics 37:219-25. 1996
    ..Interspecific backcross mapping yielded a map order and distances (cM) of cen-Moa1-3.1 +/- 1.8-Piga-2.1 +/- 1.5-Amel, indicating that Moa1 is located much farther away from the pseudoautosomal region than its human homolog...
  69. ncbi Protein interactions during assembly of the enamel organic extracellular matrix
    M L Paine
    University of Southern California, School of Dentistry, Center for Craniofacial Molecular Biology, Los Angeles, USA
    J Bone Miner Res 12:221-7. 1997
    ..Amelogenin and tuftelin fail to interact with each other. Based upon this data, and advances in the field, a model for amelogenin assemblies that direct enamel biomineralization is presented...
  70. ncbi A novel human serine-threonine phosphatase related to the Drosophila retinal degeneration C (rdgC) gene is selectively expressed in sensory neurons of neural crest origin
    E Montini
    Telethon Institute of Genetics and Medicine TIGEM, San Raffaele Biomedical Science Park, Milan, Italy
    Hum Mol Genet 6:1137-45. 1997
    ..The selective pattern of expression makes PPEF an important marker for sensory neuron differentiation and suggests a role for serine-threonine phosphatases in mammalian development...
  71. ncbi Patchy fur, a mouse coat mutation associated with X-Y nondisjunction, maps to the pseudoautosomal boundary region
    O Korobova
    Molecular Biology Program, University of Southern California, Los Angeles, California, 90089 1340, USA
    Genomics 54:556-9. 1998
    ..2-cM interval that includes the pseudoautosomal boundary. The meiotic nondisjunction phenotype may result from a chromosomal rearrangement that includes pseudoautosomal sequences and affects XY pairing...
  72. ncbi Regulation of amelogenin gene expression
    C W Gibson
    Department of Anatomy and Histology, University of Pennnsylvania School of Dental Medicine, Philadelphia 19104, USA
    Crit Rev Eukaryot Gene Expr 9:45-57. 1999
    ..The pattern of alternative splicing varies both between species and during development, which is expected to result in some diversity through varying complements of amelogenin proteins associated with this highly conserved gene...
  73. ncbi Altered amelogenin self-assembly based on mutations observed in human X-linked amelogenesis imperfecta (AIH1)
    Michael L Paine
    University of Southern California, School of Dentistry, Center for Craniofacial Molecular Biology, Los Angeles, California 90033 1004, USA
    J Biol Chem 277:17112-6. 2002
    ....
  74. ncbi Model system for evaluation of alternative splicing: exon skipping
    Z A Yuan
    Department of Anatomy and Histology, University of Pennsylvania School of Dental Medicine, Philadelphia, Pennsylvania 19104, USA
    DNA Cell Biol 20:807-13. 2001
    ....
  75. ncbi Polypeptides translated from alternatively spliced transcripts of the amelogenin gene, devoid of the exon 6a, b, c region, have specific effects on tooth germ development in culture
    Kevin Tompkins
    Department of Cell and Molecular Biology, Northwestern University, Ward 13 100, 303 E Chicago Avenue, Chicago, IL 60611, USA
    Connect Tissue Res 43:224-31. 2002
    ..Since the recombinant peptides are active, their corresponding tissue forms may be important in the stimulation of mesenchymal tissue differentiation. Thus, these specific amelogenin proteins may be involved in tooth morphogenesis...
  76. ncbi The small bovine amelogenin LRAP fails to rescue the amelogenin null phenotype
    E Chen
    Department of Anatomy and Cell Biology, University of Pennsylvania School of Dental Medicine, 240 S 40th St, Philadelphia, PA, USA
    Calcif Tissue Int 73:487-95. 2003
    ..one of the amelogenins, we have created a transgenic mouse that expresses bovine leucine-rich amelogenin peptide (LRAP) in the enamel-secreting ameloblast cells of the dental organ...
  77. ncbi Two related low molecular mass polypeptide isoforms of amelogenin have distinct activities in mouse tooth germ differentiation in vitro
    Kevin Tompkins
    Department of Cell and Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    J Bone Miner Res 20:341-9. 2005
    ..Our results show that these individual proteins have specific but quite different effects on epithelial-derived ameloblasts versus mesenchymal-derived odontoblasts...
  78. ncbi Expression pattern of Dlx3 during cell differentiation in mineralized tissues
    Sonia Ghoul-Mazgar
    Laboratoire de Biologie Oro faciale et Pathologie INSERM U 714, 15 21 rue de l Ecole de Médecine 75270, Universités Paris 7 and Paris 6 IFR58, Paris Cedex 06, France
    Bone 37:799-809. 2005
    ..The present data on Dlx3 and recently published functional studies show that this transcription factor may be instrumental during growth in the control of matrix deposition and biomineralization in the entire skeleton...
  79. ncbi Thermal denaturation of a recombinant mouse amelogenin: circular dichroism and differential scanning calorimetric studies
    Motohisa Oobatake
    Protein Engineering Research Institute, Osaka, Japan
    Proteins 62:461-9. 2006
    ..The thermodynamic characteristics of rM179 are unique and different from a typical globular protein, proline-rich peptides, and a molten globule state...
  80. ncbi Altering biomineralization by protein design
    DanHong Zhu
    University of Southern California, Center for Craniofacial Molecular Biology, Los Angeles, 90033, USA
    J Biol Chem 281:21173-82. 2006
    ....
  81. pmc Origin, splicing, and expression of rodent amelogenin exon 8
    J D Bartlett
    Department of Cytokine Biology, Harvard School of Dental Medicine, Boston, MA 02115, USA
    J Dent Res 85:894-9. 2006
    ..No downstream genomic sequences homologous to exons 4-5 were present in the bovine or human amelogenin genes, suggesting that this translocation occurred only in rodents...
  82. pmc Physical dissection of the CCAAT/enhancer-binding protein alpha in regulating the mouse amelogenin gene
    Yucheng Xu
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA
    Biochem Biophys Res Commun 354:56-61. 2007
    ..Co-immunoprecipitation analyses identified that the carboxyl-terminal domain (residues 218-359) of C/EBPalpha is required for the C/EBPalpha-Msx2 protein-protein interactions...
  83. ncbi Amelogenin- and enamelysin (Mmp-20)-deficient mice display altered birefringence in the secretory-stage enamel organic extracellular matrix
    Alexandre R Espírito Santo
    Department of Morphology, Piracicaba Dental School, State University of Campinas, Piracicaba, SP, Brazil
    Connect Tissue Res 48:39-45. 2007
    ..In the present work we analyzed the birefringence of secretory-stage enamel organic ECM in amelogenin (Amelx)- and enamelysin (Mmp20)-deficient mice...
  84. ncbi Spatiotemporal expression of ameloblastin isoforms during murine tooth development
    Rajeswari M H Ravindranath
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California Los Angeles, California 90033, USA
    J Biol Chem 282:36370-6. 2007
    ..These observations suggest that the 37-kDa isoform interacts with amelogenin during early tooth development...
  85. pmc Identification of the functional activity of the [A-4] amelogenin gene splice product in newborn mouse ameloblasts
    Stanca Iacob
    Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Bone 42:1072-9. 2008
    ..is characterized by the prominent expression and subsequent secretion of two isoforms of amelogenin, M180 and M59 (LRAP, [A-4]). Amelogenin deposition into the ameloblast extracellular matrix promotes enamel biomineralization...
  86. pmc The leucine-rich amelogenin peptide alters the amelogenin null enamel phenotype
    Carolyn W Gibson
    Department of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104 6030, USA
    Cells Tissues Organs 189:169-74. 2009
    ..b>Amelx null (KO) mice have hypoplastic, disorganized enamel similar to that of human patients with mutations in the AMELX ..
  87. pmc Biglycan overexpression on tooth enamel formation in transgenic mice
    Xin Wen
    University of Southern California School of Dentistry, Center for Craniofacial Molecular Biology, Los Angeles, California, USA
    Anat Rec (Hoboken) 291:1246-53. 2008
    ..These results suggested that increasing the biglycan expression, in the cells that synthesize the precursor protein matrix for enamel, has a negligible influence on amelogenesis...
  88. pmc The LIM homeodomain transcription factors Lhx6 and Lhx7 are key regulators of mammalian dentition
    Myrto Denaxa
    Division of Molecular Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Dev Biol 333:324-36. 2009
    ..Our experiments demonstrate that the redundant activities of the LIM homeodomain proteins Lhx6 and Lhx7 are critical for craniofacial development and patterning of mammalian dentition...
  89. doi Cytomegalovirus induces stage-dependent enamel defects and misexpression of amelogenin, enamelin and dentin sialophosphoprotein in developing mouse molars
    Tina Jaskoll
    Laboratory for Developmental Genetics, University of Southern California, Los Angeles, CA 90089 0641, USA
    Cells Tissues Organs 192:221-39. 2010
    ..This viral-induced pathology is coincident with stage-dependent changes in Amelx, Enam and Dspp gene expression, distribution of amelogenin, enamelin and DSP proteins, cell proliferation ..
  90. pmc Tbx1 regulates progenitor cell proliferation in the dental epithelium by modulating Pitx2 activation of p21
    Huojun Cao
    Institute of Biosciences and Technology, Texas A and M Health Science Center, Houston, TX 77030, USA
    Dev Biol 347:289-300. 2010
    ..These data demonstrate new functional mechanisms for Tbx1 in tooth morphogenesis and provide a molecular basis for craniofacial defects in DiGeorge syndrome patients...
  91. pmc Wnt5a regulates growth, patterning, and odontoblast differentiation of developing mouse tooth
    Minkui Lin
    Department of Periodontology, Affiliated Stomatological Hospital, Fujian Medical University, Fuzhou, Fujian, China
    Dev Dyn 240:432-40. 2011
    ..Our results suggest that Wnt5a regulates growth, patterning, and odontoblast differentiation during odontogenesis, at least partially by modulating Wnt/β-catenin canonical signaling...
  92. pmc Alk5-mediated transforming growth factor β signaling acts upstream of fibroblast growth factor 10 to regulate the proliferation and maintenance of dental epithelial stem cells
    Hu Zhao
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Mol Cell Biol 31:2079-89. 2011
    ..Therefore, we propose that Alk5 functions upstream of Fgf10 to regulate TA cell proliferation and stem cell maintenance and that this signaling mechanism is crucial for stem cell-mediated tooth regeneration...
  93. pmc SMAD4-mediated WNT signaling controls the fate of cranial neural crest cells during tooth morphogenesis
    Jingyuan Li
    Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Development 138:1977-89. 2011
    ..Taken together, our study demonstrates that SMAD4 plays a crucial role in regulating the interplay between TGFβ/BMP and WNT signaling to ensure the proper CNC cell fate decision during organogenesis...
  94. doi Amelogenin promotes odontoblast-like MDPC-23 cell differentiation via activation of ERK1/2 and p38 MAPK
    Naihui Yao
    Department of Stomatology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, People s Republic of China
    Mol Cell Biochem 355:91-7. 2011
    Amelogenin (AMG) is a highly conserved protein secreted by ameloblasts. Some research indicates that AMG might induce the differentiation and maturation of odontoblasts...
  95. ncbi Mapping of a mouse homolog of a heterochromatin protein gene the X chromosome
    R M Hamvas
    Department of Biochemistry and Molecular Genetics, St Mary s Hospital Medical School, London, UK
    Mamm Genome 2:72-5. 1992
    ..One of these loci--Cbx-rs1--maps to the X Chromosome (Chr), 1 cM proximal to Amg and outside the X-inactivation center region.
  96. ncbi Linkage of amelogenin (Amel) to the distal portion of the mouse X chromosome
    V M Chapman
    Molecular and Cellular Biology Department, Roswell Park Cancer Institute, Buffalo, New York 14263
    Genomics 10:23-8. 1991
    ..of genomic DNA from the mouse using this cDNA as a probe indicates that there is only one mouse amelogenin (Amel) gene...
  97. pmc A synthetic, chemically modified ribozyme eliminates amelogenin, the major translation product in developing mouse enamel in vivo
    S P Lyngstadaas
    Biotechnology Centre of Oslo, The National Hospital, University of Oslo, Norway
    EMBO J 14:5224-9. 1995
    ....
  98. ncbi Alternative splicing of amelogenins
    J P Simmer
    University of Texas School of Dentistry, Health Science Center at San Antonio, Department of Pediatric Dentistry 78284 7888, USA
    Connect Tissue Res 32:131-6. 1995
    ..These data indicate that alternatively spliced amelogenin mRNAs are translated into protein and secreted into the enamel matrix...
  99. ncbi Different chromosomal localization of the Clcn4 gene in Mus spretus and C57BL/6J mice
    E I Rugarli
    Telethon Institute of Genetics and Medicine TIGEM, San Raffaele Biomedical Science Park, Milano, Italy
    Nat Genet 10:466-71. 1995
    ..Our data provide molecular evidence for a major divergence near the pseudoautosomal region, consistent with the hypothesis that hybrid sterility in these species results from abnormal pairing of sex chromosomes during male meiosis...
  100. ncbi Linkage of phosphoribosylpyrophosphate synthetases 1 and 2, Prps1 and Prps2, on the mouse X chromosome
    K Lee
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263
    Mamm Genome 5:612-5. 1994
    ..a mouse X Chr region that is homologous to Xq21-24 on the human X Chr while Prps2 mapped between DXWas31 and Amg, a region that is homologous to the map position of PRPS2 on Xp22 of the human X Chr...
  101. ncbi Distal-less and other homeobox genes in the development of the dentition
    K M Weiss
    Department of Anthropology, Penn State University, University Park 16802
    J Exp Zool 270:273-84. 1994
    ..The screening approach with degenerate primers is a successful way to identify new as well as previously known regulatory genes expressed in developing tooth embryos...

Research Grants12

  1. REGULATION OF EXPRESSION OF THE AMELOGENIN GENES
    CAROLYN GIBSON; Fiscal Year: 2001
    ..Alternative splicing of exon 6 results in translation of LRAP (leucine rich amelogenin protein), which is highly represented in developing bovine enamel; exon 3 includes the ..
  2. The Impact of Fluoride on the Rho Signaling Pathway and the Actin Cytoskeleton
    CAROLYN GIBSON; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  3. LECTIN-LIKE PROPERTIES OF AMELOGENINS
    RAJESWARI RAVINDRANATH; Fiscal Year: 2004
    ..These experiments are a logical extension of the newly identified lectin-like properties of amelogenins (Ravindranath et al. Submitted), which are postulated to play a functional role in normal enamel biomineralization. ..
  4. MMP-20 AND MMP-20 DOMAIN FUNCTION IN FORMING ENAMEL
    John Bartlett; Fiscal Year: 2006
    ..This application builds on results from a highly productive R29 grant (DE12098). ..
  5. DETERMINANTS OF ROOT RESORPTION DUE TO ORTHODONTIC MOVEMENT
    Margarita Zeichner David; Fiscal Year: 2005
    ....
  6. CEMENTOGENESIS: ROLE OF HERTWIG'S EPITHELIAL ROOT SHEATH
    Margarita Zeichner David; Fiscal Year: 2006
    ..Although rare, individuals with root agenesis have been documented. ..
  7. Eda/Edar Regulation of Embryonic SMG Development
    Tina Jaskoll; Fiscal Year: 2007
    ....
  8. TISSUE ENGINEERING FOR PERIODONTIUM REPAIR
    Margarita Zeichner David; Fiscal Year: 2003
    ..The data generated in this study will also provide information related to the regulation of root formation and possible ways to improve the diagnosis, treatment, and prognosis of tooth loss due to aging or periodontal diseases. ..
  9. THE GENOTYPE AND PHENOTYPE AMELOGENESIS IMPERFECTA
    John Wright; Fiscal Year: 2004
    ..Knowledge of the molecular determinants of morphogenesis and tissue formation will allow novel and more effective treatments and more accurate diagnosis of the diverse hereditary conditions affecting teeth. ..
  10. MODIFYING GENE DETERMINANTS OF TOOTH AND BONE PHENOTYPES
    John Wright; Fiscal Year: 2007
    ..abstract_text> ..
  11. Phenotype and Gene Expression in Odontogenic Tumors
    JOHN T WRIGHT; Fiscal Year: 2010
    ..Gene data will be placed on our web site in a timely fashion for data sharing. These studies will provide the first detailed mutational and gene profile studies of human odontogenic tumors. ..
  12. MOLECULAR REGULATION OF PERIODONTIUM FORMATION
    Margarita Zeichner David; Fiscal Year: 2010
    ..Additionally, understanding root and periodontium development is critical to establish genetical and tissue engineering therapies for periodontium regeneration. ..