Amigo1

Summary

Gene Symbol: Amigo1
Description: adhesion molecule with Ig like domain 1
Alias: Amigo, ali2, amphoterin-induced protein 1, AMIGO-1, alivin 2, amigo1, amphoterin induced gene and ORF (Amigo)
Species: mouse
Products:     Amigo1

Top Publications

  1. Ramamoorthy S, Leibach F, Mahesh V, Han H, Yang Feng T, Blakely R, et al. Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta. Biochem J. 1994;300 ( Pt 3):893-900 pubmed
    ..9 kb transcript. Somatic cell hybrid and in situ hybridization studies indicate that the cloned taurine transporter is localized to human chromosome 3 p24-->p26. ..
  2. Kuja Panula J, Kiiltomäki M, Yamashiro T, Rouhiainen A, Rauvala H. AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats. J Cell Biol. 2003;160:963-73 pubmed
    ..We named this gene amphoterin-induced gene and ORF (AMIGO), and also cloned two other novel genes homologous to AMIGO (AMIGO2 and AMIGO3)...
  3. Ono T, Sekino Suzuki N, Kikkawa Y, Yonekawa H, Kawashima S. Alivin 1, a novel neuronal activity-dependent gene, inhibits apoptosis and promotes survival of cerebellar granule neurons. J Neurosci. 2003;23:5887-96 pubmed
    ..Mouse ali1 was mapped to a locus approximately 55.3 cM from the centromere on chromosome 15 that is syntenic to positional candidate loci for familial Alzheimer's disease type 5 and Parkinson's disease 8 on human chromosome 12. ..
  4. Mandai K, Guo T, St Hillaire C, Meabon J, Kanning K, Bothwell M, et al. LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development. Neuron. 2009;63:614-27 pubmed publisher
    ..These findings show that LIGs physically interact with RTKs and modulate their activities to control axonal extension, guidance and branching. ..
  5. Chen Y, Hor H, Tang B. AMIGO is expressed in multiple brain cell types and may regulate dendritic growth and neuronal survival. J Cell Physiol. 2012;227:2217-29 pubmed publisher
    Amphoterin-induced gene and ORF (AMIGO) is a brain-enriched transmembrane immunoglobulin (Ig) superfamily protein with six extracellular leucine-rich repeats (LRR) and a single immunoglobulin-like (Ig) domain...
  6. Peltola M, Kuja Panula J, Lauri S, Taira T, Rauvala H. AMIGO is an auxiliary subunit of the Kv2.1 potassium channel. EMBO Rep. 2011;12:1293-9 pubmed publisher
    ..Here we identify AMIGO (amphoterin-induced gene and ORF), a neuronal adhesion protein with leucine-rich repeat and immunoglobin domains, ..
  7. Peltola M, Kuja Panula J, Liuhanen J, Voikar V, Piepponen P, Hiekkalinna T, et al. AMIGO-Kv2.1 Potassium Channel Complex Is Associated With Schizophrenia-Related Phenotypes. Schizophr Bull. 2016;42:191-201 pubmed publisher
    ..The Kv2.1 auxiliary subunit AMIGO constitutes an integral part of the Kv2.1 channel complex in brain and regulates the activity of the channel...

Scientific Experts

Detail Information

Publications7

  1. Ramamoorthy S, Leibach F, Mahesh V, Han H, Yang Feng T, Blakely R, et al. Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta. Biochem J. 1994;300 ( Pt 3):893-900 pubmed
    ..9 kb transcript. Somatic cell hybrid and in situ hybridization studies indicate that the cloned taurine transporter is localized to human chromosome 3 p24-->p26. ..
  2. Kuja Panula J, Kiiltomäki M, Yamashiro T, Rouhiainen A, Rauvala H. AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats. J Cell Biol. 2003;160:963-73 pubmed
    ..We named this gene amphoterin-induced gene and ORF (AMIGO), and also cloned two other novel genes homologous to AMIGO (AMIGO2 and AMIGO3)...
  3. Ono T, Sekino Suzuki N, Kikkawa Y, Yonekawa H, Kawashima S. Alivin 1, a novel neuronal activity-dependent gene, inhibits apoptosis and promotes survival of cerebellar granule neurons. J Neurosci. 2003;23:5887-96 pubmed
    ..Mouse ali1 was mapped to a locus approximately 55.3 cM from the centromere on chromosome 15 that is syntenic to positional candidate loci for familial Alzheimer's disease type 5 and Parkinson's disease 8 on human chromosome 12. ..
  4. Mandai K, Guo T, St Hillaire C, Meabon J, Kanning K, Bothwell M, et al. LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development. Neuron. 2009;63:614-27 pubmed publisher
    ..These findings show that LIGs physically interact with RTKs and modulate their activities to control axonal extension, guidance and branching. ..
  5. Chen Y, Hor H, Tang B. AMIGO is expressed in multiple brain cell types and may regulate dendritic growth and neuronal survival. J Cell Physiol. 2012;227:2217-29 pubmed publisher
    Amphoterin-induced gene and ORF (AMIGO) is a brain-enriched transmembrane immunoglobulin (Ig) superfamily protein with six extracellular leucine-rich repeats (LRR) and a single immunoglobulin-like (Ig) domain...
  6. Peltola M, Kuja Panula J, Lauri S, Taira T, Rauvala H. AMIGO is an auxiliary subunit of the Kv2.1 potassium channel. EMBO Rep. 2011;12:1293-9 pubmed publisher
    ..Here we identify AMIGO (amphoterin-induced gene and ORF), a neuronal adhesion protein with leucine-rich repeat and immunoglobin domains, ..
  7. Peltola M, Kuja Panula J, Liuhanen J, Voikar V, Piepponen P, Hiekkalinna T, et al. AMIGO-Kv2.1 Potassium Channel Complex Is Associated With Schizophrenia-Related Phenotypes. Schizophr Bull. 2016;42:191-201 pubmed publisher
    ..The Kv2.1 auxiliary subunit AMIGO constitutes an integral part of the Kv2.1 channel complex in brain and regulates the activity of the channel...