Apoe

Summary

Gene Symbol: Apoe
Description: apolipoprotein E
Alias: AI255918, Apo-E, apolipoprotein E
Species: mouse
Products:     Apoe

Top Publications

  1. Tsiantoulas D, Diehl C, Witztum J, Binder C. B cells and humoral immunity in atherosclerosis. Circ Res. 2014;114:1743-56 pubmed publisher
    ..Moreover, we will highlight potential therapeutic approaches focusing on B-cell depletion that could be used to translate experimental evidence to human disease...
  2. Zhou C, Liu L, Liu L, Zhang M, Guo H, Pan J, et al. Salusin-β not salusin-α promotes vascular inflammation in ApoE-deficient mice via the I-κBα/NF-κB pathway. PLoS ONE. 2014;9:e91468 pubmed publisher
    ..In this study, we observed the effects of salusins on vascular inflammation in apoE-deficient (apoE-/-) mice...
  3. Kayashima Y, Tomita H, Zhilicheva S, Kim S, Kim H, Bennett B, et al. Quantitative trait loci affecting atherosclerosis at the aortic root identified in an intercross between DBA2J and 129S6 apolipoprotein E-null mice. PLoS ONE. 2014;9:e88274 pubmed publisher
    b>Apolipoprotein E-null mice on a DBA/2J genetic background (DBA-apoE) are highly susceptible to atherosclerosis in the aortic root area compared with those on a 129S6 background (129-apoE)...
  4. Secchiero P, Candido R, Corallini F, Zacchigna S, Toffoli B, Rimondi E, et al. Systemic tumor necrosis factor-related apoptosis-inducing ligand delivery shows antiatherosclerotic activity in apolipoprotein E-null diabetic mice. Circulation. 2006;114:1522-30 pubmed
    ..human TRAIL and an adeno-associated virus vector expressing human TRAIL were used to deliver TRAIL in apolipoprotein E (apoE)-null mice in which diabetes mellitus was induced by destruction of islet cells with streptozotocin...
  5. Langheinrich A, Sedding D, Kampschulte M, Moritz R, Wilhelm J, Haberbosch W, et al. 3-Deazaadenosine inhibits vasa vasorum neovascularization in aortas of ApoE(-/-)/LDL(-/-) double knockout mice. Atherosclerosis. 2009;202:103-10 pubmed publisher
    ..c(3)Ado), an anti-inflammatory and anti-proliferative drug, on plaque progression and VV neovascularization in apoE(-/-)/LDL(-/-) double knockout mice...
  6. Nathan B, Nisar R, Short J, Randall S, Grissom E, Griffin G, et al. Delayed olfactory nerve regeneration in ApoE-deficient mice. Brain Res. 2005;1041:87-94 pubmed
    b>Apolipoprotein E (apoE), a lipid transporting protein, is extensively expressed in the primary olfactory pathway, but its function is unknown...
  7. Lewis R, Jackson C, Morgan B, Hughes T. The membrane attack complex of complement drives the progression of atherosclerosis in apolipoprotein E knockout mice. Mol Immunol. 2010;47:1098-105 pubmed publisher
    ..C6 (C6(-/-)) deficient and CD59a (Cd59a(-/-)) knockout mice were separately crossed onto the apolipoprotein E knockout (apoE(-/-)) background...
  8. Bien Ly N, Gillespie A, Walker D, Yoon S, Huang Y. Reducing human apolipoprotein E levels attenuates age-dependent Aβ accumulation in mutant human amyloid precursor protein transgenic mice. J Neurosci. 2012;32:4803-11 pubmed publisher
    ..Brain amyloid-β (Aβ) accumulation depends on age and apoE isoforms (apoE4 > apoE3) both in humans and in transgenic mouse models...
  9. Huang Y, Liu X, Rall S, Taylor J, von Eckardstein A, Assmann G, et al. Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemia. J Biol Chem. 1998;273:26388-93 pubmed
    ..we found that expressing high plasma levels of human apoE3 in transgenic mice lacking endogenous mouse apoE caused HTG...
  10. Ervinna N, Mita T, Yasunari E, Azuma K, Tanaka R, Fujimura S, et al. Anagliptin, a DPP-4 inhibitor, suppresses proliferation of vascular smooth muscles and monocyte inflammatory reaction and attenuates atherosclerosis in male apo E-deficient mice. Endocrinology. 2013;154:1260-70 pubmed publisher
    ..To gain insights into their mechanism of action, 9-wk-old male apolipoprotein E (apoE)-deficient mice were fed a DPP-4 inhibitor, anagliptin-containing diet...

Detail Information

Publications62

  1. Tsiantoulas D, Diehl C, Witztum J, Binder C. B cells and humoral immunity in atherosclerosis. Circ Res. 2014;114:1743-56 pubmed publisher
    ..Moreover, we will highlight potential therapeutic approaches focusing on B-cell depletion that could be used to translate experimental evidence to human disease...
  2. Zhou C, Liu L, Liu L, Zhang M, Guo H, Pan J, et al. Salusin-β not salusin-α promotes vascular inflammation in ApoE-deficient mice via the I-κBα/NF-κB pathway. PLoS ONE. 2014;9:e91468 pubmed publisher
    ..In this study, we observed the effects of salusins on vascular inflammation in apoE-deficient (apoE-/-) mice...
  3. Kayashima Y, Tomita H, Zhilicheva S, Kim S, Kim H, Bennett B, et al. Quantitative trait loci affecting atherosclerosis at the aortic root identified in an intercross between DBA2J and 129S6 apolipoprotein E-null mice. PLoS ONE. 2014;9:e88274 pubmed publisher
    b>Apolipoprotein E-null mice on a DBA/2J genetic background (DBA-apoE) are highly susceptible to atherosclerosis in the aortic root area compared with those on a 129S6 background (129-apoE)...
  4. Secchiero P, Candido R, Corallini F, Zacchigna S, Toffoli B, Rimondi E, et al. Systemic tumor necrosis factor-related apoptosis-inducing ligand delivery shows antiatherosclerotic activity in apolipoprotein E-null diabetic mice. Circulation. 2006;114:1522-30 pubmed
    ..human TRAIL and an adeno-associated virus vector expressing human TRAIL were used to deliver TRAIL in apolipoprotein E (apoE)-null mice in which diabetes mellitus was induced by destruction of islet cells with streptozotocin...
  5. Langheinrich A, Sedding D, Kampschulte M, Moritz R, Wilhelm J, Haberbosch W, et al. 3-Deazaadenosine inhibits vasa vasorum neovascularization in aortas of ApoE(-/-)/LDL(-/-) double knockout mice. Atherosclerosis. 2009;202:103-10 pubmed publisher
    ..c(3)Ado), an anti-inflammatory and anti-proliferative drug, on plaque progression and VV neovascularization in apoE(-/-)/LDL(-/-) double knockout mice...
  6. Nathan B, Nisar R, Short J, Randall S, Grissom E, Griffin G, et al. Delayed olfactory nerve regeneration in ApoE-deficient mice. Brain Res. 2005;1041:87-94 pubmed
    b>Apolipoprotein E (apoE), a lipid transporting protein, is extensively expressed in the primary olfactory pathway, but its function is unknown...
  7. Lewis R, Jackson C, Morgan B, Hughes T. The membrane attack complex of complement drives the progression of atherosclerosis in apolipoprotein E knockout mice. Mol Immunol. 2010;47:1098-105 pubmed publisher
    ..C6 (C6(-/-)) deficient and CD59a (Cd59a(-/-)) knockout mice were separately crossed onto the apolipoprotein E knockout (apoE(-/-)) background...
  8. Bien Ly N, Gillespie A, Walker D, Yoon S, Huang Y. Reducing human apolipoprotein E levels attenuates age-dependent Aβ accumulation in mutant human amyloid precursor protein transgenic mice. J Neurosci. 2012;32:4803-11 pubmed publisher
    ..Brain amyloid-β (Aβ) accumulation depends on age and apoE isoforms (apoE4 > apoE3) both in humans and in transgenic mouse models...
  9. Huang Y, Liu X, Rall S, Taylor J, von Eckardstein A, Assmann G, et al. Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemia. J Biol Chem. 1998;273:26388-93 pubmed
    ..we found that expressing high plasma levels of human apoE3 in transgenic mice lacking endogenous mouse apoE caused HTG...
  10. Ervinna N, Mita T, Yasunari E, Azuma K, Tanaka R, Fujimura S, et al. Anagliptin, a DPP-4 inhibitor, suppresses proliferation of vascular smooth muscles and monocyte inflammatory reaction and attenuates atherosclerosis in male apo E-deficient mice. Endocrinology. 2013;154:1260-70 pubmed publisher
    ..To gain insights into their mechanism of action, 9-wk-old male apolipoprotein E (apoE)-deficient mice were fed a DPP-4 inhibitor, anagliptin-containing diet...
  11. Reddick R, Zhang S, Maeda N. Aortic atherosclerotic plaque injury in apolipoprotein E deficient mice. Atherosclerosis. 1998;140:297-305 pubmed
    The acute platelet response and chronic smooth muscle cell (SMC) proliferation following aortic injury in apolipoprotein E-deficient mice was investigated...
  12. Rozenberg I, Sluka S, Rohrer L, Hofmann J, Becher B, Akhmedov A, et al. Histamine H1 receptor promotes atherosclerotic lesion formation by increasing vascular permeability for low-density lipoproteins. Arterioscler Thromb Vasc Biol. 2010;30:923-30 pubmed publisher
    ..Whether this affects the formation of atherosclerotic lesions, however, remains elusive. Apolipoprotein E-null (ApoE(-/-)) mice treated with a histamine H1 receptor but not an H2 receptor antagonist developed 40% ..
  13. Di Bartolo B, Cartland S, Harith H, Bobryshev Y, Schoppet M, Kavurma M. TRAIL-deficiency accelerates vascular calcification in atherosclerosis via modulation of RANKL. PLoS ONE. 2013;8:e74211 pubmed publisher
    ..isolated from TRAIL(-/-) and wild-type mice, as well as in vivo, in advanced atherosclerotic lesions of TRAIL(-/-)ApoE(-/-) mice. The involvement of OPG and RANKL in this process was also examined...
  14. Malloy S, Altenburg M, Knouff C, Lanningham Foster L, Parks J, Maeda N. Harmful effects of increased LDLR expression in mice with human APOE*4 but not APOE*3. Arterioscler Thromb Vasc Biol. 2004;24:91-7 pubmed
    ..hypothesis, doubling Ldlr expression caused severe atherosclerosis with marked accumulation of cholesterol-rich, apoE-poor remnants in mice with human apoE4, but not apoE3, when the animals were fed a Western-type diet...
  15. Maekawa T, Takahashi N, Tabeta K, Aoki Y, Miyashita H, Miyauchi S, et al. Chronic oral infection with Porphyromonas gingivalis accelerates atheroma formation by shifting the lipid profile. PLoS ONE. 2011;6:e20240 pubmed publisher
    ..Although several studies have suggested that certain periodontopathic bacteria accelerate atherogenesis in apolipoprotein E-deficient mice, the mechanistic link between cholesterol accumulation and periodontal infection-induced ..
  16. Smith E, Prasad K, Butcher M, Dobrian A, Kolls J, Ley K, et al. Blockade of interleukin-17A results in reduced atherosclerosis in apolipoprotein E-deficient mice. Circulation. 2010;121:1746-55 pubmed publisher
    ..IL-17A was found to be elevated in the plasma and tissues of apolipoprotein E-deficient (Apoe(-/-)) mice...
  17. Wu D, Sharan C, Yang H, Goodwin J, Zhou L, Grabowski G, et al. Apolipoprotein E-deficient lipoproteins induce foam cell formation by downregulation of lysosomal hydrolases in macrophages. J Lipid Res. 2007;48:2571-8 pubmed
    b>Apolipoprotein E (apoE) deficiency has been suggested to induce foam cell formation...
  18. Yu Z, Crichton I, Tang S, Hui Y, Ricciotti E, Levin M, et al. Disruption of the 5-lipoxygenase pathway attenuates atherogenesis consequent to COX-2 deletion in mice. Proc Natl Acad Sci U S A. 2012;109:6727-32 pubmed publisher
    ..When crossed into ApoE-deficient hyperlipidemic mice, COX-2 deletion accelerated atherogenesis in both genders, with lesions exhibiting ..
  19. Yuan Z, Pei H, Roberts D, Zhang Z, Rowlan J, Matsumoto A, et al. Quantitative trait locus analysis of neointimal formation in an intercross between C57BL/6 and C3H/HeJ apolipoprotein E-deficient mice. Circ Cardiovasc Genet. 2009;2:220-8 pubmed publisher
    ..and C3H/HeJ (C3H) exhibit marked differences in neointimal formation after arterial injury when deficient in apolipoprotein E (apoE(-/-)) and fed a Western diet...
  20. Fryer J, DeMattos R, McCormick L, O Dell M, Spinner M, Bales K, et al. The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice. J Biol Chem. 2005;280:25754-9 pubmed
    b>Apolipoprotein E (apoE), a chaperone for the amyloid beta (Abeta) peptide, regulates the deposition and structure of Abeta that deposits in the brain in Alzheimer disease (AD)...
  21. Ortiz Muñoz G, Martin Ventura J, Hernandez Vargas P, Mallavia B, Lopez Parra V, Lopez Franco O, et al. Suppressors of cytokine signaling modulate JAK/STAT-mediated cell responses during atherosclerosis. Arterioscler Thromb Vasc Biol. 2009;29:525-31 pubmed publisher
    ..SOCS were also increased in aortic lesions from apoE(-/-) mice...
  22. Hans C, Feng Y, Naura A, Zerfaoui M, Rezk B, Xia H, et al. Protective effects of PARP-1 knockout on dyslipidemia-induced autonomic and vascular dysfunction in ApoE mice: effects on eNOS and oxidative stress. PLoS ONE. 2009;4:e7430 pubmed publisher
    ..Apolipoprotein (ApoE)(-/-) mice fed a high-fat diet were used as a model of atherosclerosis...
  23. Mitchel R, Hasu M, Bugden M, Wyatt H, Hildebrandt G, Chen Y, et al. Low-dose radiation exposure and protection against atherosclerosis in ApoE(-/-) mice: the influence of P53 heterozygosity. Radiat Res. 2013;179:190-9 pubmed publisher
    We recently described the effects of low-dose γ-radiation exposures on atherosclerosis in genetically susceptible (ApoE(-/-)) mice with normal p53 function...
  24. Manning Tobin J, Moore K, Seimon T, Bell S, Sharuk M, Alvarez Leite J, et al. Loss of SR-A and CD36 activity reduces atherosclerotic lesion complexity without abrogating foam cell formation in hyperlipidemic mice. Arterioscler Thromb Vasc Biol. 2009;29:19-26 pubmed publisher
    ..To test the impact of deleting these receptors, we generated Apoe(-/-) mice lacking both SR-A and CD36 and fed them a Western diet for 12 weeks...
  25. Thorp E, Li G, Seimon T, Kuriakose G, Ron D, Tabas I. Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP. Cell Metab. 2009;9:474-81 pubmed publisher
    ..To test the effect of CHOP deficiency in vivo, aortic root lesions of fat-fed Chop+/+;Apoe-/- and Chop-/-;Apoe-/- mice were analyzed for size and morphology...
  26. Altenburg M, Arbones Mainar J, Johnson L, Wilder J, Maeda N. Human LDL receptor enhances sequestration of ApoE4 and VLDL remnants on the surface of hepatocytes but not their internalization in mice. Arterioscler Thromb Vasc Biol. 2008;28:1104-10 pubmed publisher
    ..Here we investigate the mechanism by which mice expressing human apoE isoforms recapitulate this association when they also express high levels of human low-density lipoprotein receptor ..
  27. Kunieda T, Minamino T, Nishi J, Tateno K, Oyama T, Katsuno T, et al. Angiotensin II induces premature senescence of vascular smooth muscle cells and accelerates the development of atherosclerosis via a p21-dependent pathway. Circulation. 2006;114:953-60 pubmed
    ..Our results suggest a critical role of p21-dependent premature senescence of VSMCs in the pathogenesis of atherosclerosis. ..
  28. Akiyama T, Sakai S, Lambert G, Nicol C, Matsusue K, Pimprale S, et al. Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux. Mol Cell Biol. 2002;22:2607-19 pubmed
    ..Reductions in the basal levels of apolipoprotein E (apoE) mRNA in macrophages and apoE protein in total plasma and high-density lipoprotein (HDL) were also ..
  29. Wang C, Wilson W, Moore S, Mace B, Maeda N, Schmechel D, et al. Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology. Neurobiol Dis. 2005;18:390-8 pubmed
    The human APOE*4 allele is associated with an early age of onset and increased risk of Alzheimer's disease (AD). Long before the onset of AD, cognitive deficits can be identified in APOE*4 carriers...
  30. Bourassa P, Milos P, Gaynor B, Breslow J, Aiello R. Estrogen reduces atherosclerotic lesion development in apolipoprotein E-deficient mice. Proc Natl Acad Sci U S A. 1996;93:10022-7 pubmed
    We have studied the effects of endogenous and exogenous estrogen on atherosclerotic lesions in apolipoprotein E-deficient mice. Female mice ovariectomized (OVX) at weaning displayed increases (P < 0...
  31. Massberg S, Brand K, Grüner S, Page S, Müller E, Muller I, et al. A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation. J Exp Med. 2002;196:887-96 pubmed
    ..Here, we show in vivo that platelets adhere to the vascular endothelium of the carotid artery in ApoE(-)(/)(-) mice before the development of manifest atherosclerotic lesions...
  32. Lammers B, Out R, Hildebrand R, Quinn C, Williamson D, Hoekstra M, et al. Independent protective roles for macrophage Abcg1 and Apoe in the atherosclerotic lesion development. Atherosclerosis. 2009;205:420-6 pubmed publisher
    ATP-binding cassette transporter G1 (Abcg1) and apolipoprotein E (Apoe) play a role in macrophage cholesterol efflux and consequently the development of atherosclerosis...
  33. Deane R, Sagare A, Hamm K, Parisi M, Lane S, Finn M, et al. apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. J Clin Invest. 2008;118:4002-13 pubmed publisher
    ..How apoE isoforms influence Abeta accumulation in the brain has, however, remained unclear...
  34. Nathan B, Chang K, Bellosta S, Brisch E, Ge N, Mahley R, et al. The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization. J Biol Chem. 1995;270:19791-9 pubmed
    ....
  35. Dansky H, Charlton S, Barlow C, Tamminen M, Smith J, Frank J, et al. Apo A-I inhibits foam cell formation in Apo E-deficient mice after monocyte adherence to endothelium. J Clin Invest. 1999;104:31-9 pubmed
    We have previously shown that expression of the human apo A-I transgene on the apo E-deficient background increases HDL cholesterol and greatly diminishes fatty streak lesion formation...
  36. Doran A, Lipinski M, Oldham S, Garmey J, Campbell K, Skaflen M, et al. B-cell aortic homing and atheroprotection depend on Id3. Circ Res. 2012;110:e1-12 pubmed publisher
    ..Loss of Id3 in Apoe(-/-) mice resulted in early and increased atherosclerosis...
  37. Moura R, Tjwa M, Vandervoort P, Van Kerckhoven S, Holvoet P, Hoylaerts M. Thrombospondin-1 deficiency accelerates atherosclerotic plaque maturation in ApoE-/- mice. Circ Res. 2008;103:1181-9 pubmed publisher
    ..Therefore, the development of atherosclerosis was compared in ApoE(-/-) and Tsp1(-/-)ApoE(-/-) mice kept on a normocholesterolemic diet...
  38. Potteaux S, Gautier E, Hutchison S, Van Rooijen N, Rader D, Thomas M, et al. Suppressed monocyte recruitment drives macrophage removal from atherosclerotic plaques of Apoe-/- mice during disease regression. J Clin Invest. 2011;121:2025-36 pubmed publisher
    ..Mice lacking the gene Apoe (Apoe-/- mice) have high levels of cholesterol and spontaneously develop atherosclerotic lesions...
  39. Paszty C, Maeda N, Verstuyft J, Rubin E. Apolipoprotein AI transgene corrects apolipoprotein E deficiency-induced atherosclerosis in mice. J Clin Invest. 1994;94:899-903 pubmed
    b>Apolipoprotein E (apo E)-deficient mice are severely hypercholesterolemic and develop advanced atheromas independent of diet...
  40. Brodbeck J, McGuire J, Liu Z, Meyer Franke A, Balestra M, Jeong D, et al. Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors. J Biol Chem. 2011;286:17217-26 pubmed publisher
    ..Correcting the pathological structure of apoE4 by disrupting domain interaction is a potential therapeutic approach to treat or prevent AD related to apoE4. ..
  41. Piedrahita J, Zhang S, Hagaman J, Oliver P, Maeda N. Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells. Proc Natl Acad Sci U S A. 1992;89:4471-5 pubmed
    We have inactivated the endogenous apolipoprotein E (apoE) gene by using gene targeting in mouse embryonic stem (ES) cells...
  42. Ozaki M, Kawashima S, Yamashita T, Hirase T, Namiki M, Inoue N, et al. Overexpression of endothelial nitric oxide synthase accelerates atherosclerotic lesion formation in apoE-deficient mice. J Clin Invest. 2002;110:331-40 pubmed
    ..We crossed eNOS-overexpressing (eNOS-Tg) mice with atherogenic apoE-deficient (apoE-KO) mice to determine whether eNOS overexpression in the endothelium could inhibit the development ..
  43. Aiello R, Perry B, Bourassa P, Robertson A, Weng W, Knight D, et al. CCR2 receptor blockade alters blood monocyte subpopulations but does not affect atherosclerotic lesions in apoE(-/-) mice. Atherosclerosis. 2010;208:370-5 pubmed publisher
    ..Elevations in CCL2 and margination of Ly-6C(hi) cells demonstrate that the role of CCR2 in controlling monocyte levels goes beyond the control of monocyte emigration. ..
  44. Shamshiev A, Ampenberger F, Ernst B, Rohrer L, Marsland B, Kopf M. Dyslipidemia inhibits Toll-like receptor-induced activation of CD8alpha-negative dendritic cells and protective Th1 type immunity. J Exp Med. 2007;204:441-52 pubmed
    ..These results show that a dyslipidemic microenvironment can directly interfere with DC responses to pathogen-derived signals and skew the development of T cell-mediated immunity. ..
  45. Wang Z, Klipfell E, Bennett B, Koeth R, Levison B, Dugar B, et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature. 2011;472:57-63 pubmed publisher
    ....
  46. Hartley C, Reddy A, Madala S, Martin McNulty B, Vergona R, Sullivan M, et al. Hemodynamic changes in apolipoprotein E-knockout mice. Am J Physiol Heart Circ Physiol. 2000;279:H2326-34 pubmed
    b>Apolipoprotein E-knockout (ApoE-KO) mice develop advanced atherosclerotic lesions by 1 yr of age and have been well characterized pathologically and morphologically, but little is known regarding their cardiovascular physiology and ..
  47. Podrez E, Byzova T, Febbraio M, Salomon R, Ma Y, Valiyaveettil M, et al. Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype. Nat Med. 2007;13:1086-95 pubmed
    ..Thus, interactions of platelet CD36 with specific endogenous oxidized lipids play a crucial role in the well-known clinical associations between dyslipidemia, oxidant stress and a prothrombotic phenotype. ..
  48. van den Elzen P, Garg S, Leon L, Brigl M, Leadbetter E, Gumperz J, et al. Apolipoprotein-mediated pathways of lipid antigen presentation. Nature. 2005;437:906-10 pubmed
    ..b>Apolipoprotein E binds lipid antigens and delivers them by receptor-mediated uptake into endosomal compartments containing CD1 ..
  49. Deuchar G, McLean D, Hadoke P, Brownstein D, Webb D, Mullins J, et al. 11β-hydroxysteroid dehydrogenase type 2 deficiency accelerates atherogenesis and causes proinflammatory changes in the endothelium in apoe-/- mice. Endocrinology. 2011;152:236-246 pubmed publisher
    ..On chow diet, E/b2 mice developed atherosclerotic lesions by 3 months of age, whereas Apolipoprotein E (Apoe(-/-)) mice remained lesion free...
  50. Xu P, Schmechel D, Rothrock Christian T, Burkhart D, Qiu H, Popko B, et al. Human apolipoprotein E2, E3, and E4 isoform-specific transgenic mice: human-like pattern of glial and neuronal immunoreactivity in central nervous system not observed in wild-type mice. Neurobiol Dis. 1996;3:229-45 pubmed
    b>Apolipoprotein E (apoE) and its three major alleles (APOE2, E3, and E4) have been implicated in Alzheimer's disease and other neurological disorders. Little is known of the role apoE plays in normal brain function and pathology...
  51. Zhang H, Guo C, Zhang A, Fan Y, Gu T, Wu D, et al. Effect of S-aspirin, a novel hydrogen-sulfide-releasing aspirin (ACS14), on atherosclerosis in apoE-deficient mice. Eur J Pharmacol. 2012;697:106-16 pubmed publisher
    ..ACS14 (2-acetyloxybenzoic acid 4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl ester), on atherosclerotic plaques in fat-fed apoE(-/-) mice and the underlying mechanism with respect to CX3C chemokine receptor 1 (CX3CR1) in macrophages...
  52. Tam S, Ancsin J, Tan R, Kisilevsky R. Peptides derived from serum amyloid A prevent, and reverse, aortic lipid lesions in apoE-/- mice. J Lipid Res. 2005;46:2091-101 pubmed
    ..1, when delivered in liposomal formulation, are effective at preventing and reversing aortic lipid lesions in apolipoprotein E-deficient mice maintained on high-fat diets...
  53. Ji Y, Gong Y, Gan W, Beach T, Holtzman D, Wisniewski T. Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients. Neuroscience. 2003;122:305-15 pubmed
    ..A role for apoE is implicated in regeneration of synaptic circuitry after neural injury...
  54. Harrington S, Simari R, Conover C. Genetic deletion of pregnancy-associated plasma protein-A is associated with resistance to atherosclerotic lesion development in apolipoprotein E-deficient mice challenged with a high-fat diet. Circ Res. 2007;100:1696-702 pubmed
    ..determine whether PAPP-A plays an active role in the development of atherosclerosis, we crossed mice lacking apolipoprotein E (ApoE) with PAPP-A-deficient mice, generating ApoE knock-out (KO), PAPP-A KO, wild-type (WT/WT), and ApoE/..
  55. Fryer J, Simmons K, Parsadanian M, Bales K, Paul S, Sullivan P, et al. Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model. J Neurosci. 2005;25:2803-10 pubmed
    ..As in AD, the epsilon4 allele of the apolipoprotein E (apoE) gene (APOE) is a risk factor for CAA...
  56. Methia N, Andre P, Hafezi Moghadam A, Economopoulos M, Thomas K, Wagner D. ApoE deficiency compromises the blood brain barrier especially after injury. Mol Med. 2001;7:810-5 pubmed
    b>Apolipoprotein E (apoE) mediates lipoprotein uptake by receptors such as the LDL receptor (LDLR). The isoform apoE4 has been linked to Alzheimer's disease and to poor outcomes after brain injury...
  57. Barton M, Haudenschild C, d Uscio L, Shaw S, Munter K, Luscher T. Endothelin ETA receptor blockade restores NO-mediated endothelial function and inhibits atherosclerosis in apolipoprotein E-deficient mice. Proc Natl Acad Sci U S A. 1998;95:14367-72 pubmed
    ..b>Apolipoprotein E (apoE)-deficient mice and C57BL/6 control mice were treated with a Western-type diet to accelerate ..
  58. Döring Y, Drechsler M, Wantha S, Kemmerich K, Lievens D, Vijayan S, et al. Lack of neutrophil-derived CRAMP reduces atherosclerosis in mice. Circ Res. 2012;110:1052-6 pubmed publisher
    ..Compared to Apoe(-/-) mice, Cramp(-/-) Apoe(-/-) mice exhibit reduced lesion sizes with lower macrophage numbers...
  59. Daugherty A, Pure E, Delfel Butteiger D, Chen S, Leferovich J, Roselaar S, et al. The effects of total lymphocyte deficiency on the extent of atherosclerosis in apolipoprotein E-/- mice. J Clin Invest. 1997;100:1575-80 pubmed
    ..The effect of total lymphocyte deficiency on atherogenesis was investigated by crossing apo E-deficient mice (which develop atherosclerosis resembling human disease) with mice deficient in RAG2 (which is ..
  60. Satoh K, Nigro P, Matoba T, O Dell M, Cui Z, Shi X, et al. Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms. Nat Med. 2009;15:649-56 pubmed publisher
    ..Using the angiotensin II (AngII)-induced AAA model in Apoe-/- mice, we show that Apoe-/-Ppia-/- mice are completely protected from AngII-induced AAA formation, in contrast to ..
  61. Nakashima Y, Plump A, Raines E, Breslow J, Ross R. ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler Thromb. 1994;14:133-40 pubmed
    ..Mice fed the Western-type diet generally had more advanced lesions than those fed a chow diet. The apoE-deficient mouse contains the entire spectrum of lesions observed during atherogenesis and is the first mouse model ..
  62. Bruemmer D, Collins A, Noh G, Wang W, Territo M, Arias Magallona S, et al. Angiotensin II-accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice. J Clin Invest. 2003;112:1318-31 pubmed
    ..To determine the role of OPN in atherogenesis, ApoE-/-OPN+/+, ApoE-/-OPN+/-, and ApoE-/-OPN-/- mice were infused with Ang II, inducing vascular OPN expression and ..