Aqp2

Summary

Gene Symbol: Aqp2
Description: aquaporin 2
Alias: AQP-CD, WCH-CD, cph, jpk, aquaporin-2, ADH water channel, AQP-2, aquaporin-CD, collecting duct water channel protein, water channel protein for renal collecting duct
Species: mouse
Products:     Aqp2

Top Publications

  1. Moeller H, Praetorius J, Rützler M, Fenton R. Phosphorylation of aquaporin-2 regulates its endocytosis and protein-protein interactions. Proc Natl Acad Sci U S A. 2010;107:424-9 pubmed publisher
    The water channel aquaporin-2 (AQP2) is essential for urine concentration. Vasopressin regulates phosphorylation of AQP2 at four conserved serine residues at the COOH-terminal tail (S256, S261, S264, and S269)...
  2. Moeller H, Knepper M, Fenton R. Serine 269 phosphorylated aquaporin-2 is targeted to the apical membrane of collecting duct principal cells. Kidney Int. 2009;75:295-303 pubmed publisher
    ..We recently identified a novel form of aquaporin-2 that is phosphorylated at serine-269 (pS269-AQP2)...
  3. Yang B, Gillespie A, Carlson E, Epstein C, Verkman A. Neonatal mortality in an aquaporin-2 knock-in mouse model of recessive nephrogenic diabetes insipidus. J Biol Chem. 2001;276:2775-9 pubmed
    Hereditary non-X-linked nephrogenic diabetes insipidus (NDI) is caused by mutations in the aquaporin-2 (AQP2) water channel...
  4. Ge Y, Ahn D, Stricklett P, Hughes A, Yanagisawa M, Verbalis J, et al. Collecting duct-specific knockout of endothelin-1 alters vasopressin regulation of urine osmolality. Am J Physiol Renal Physiol. 2005;288:F912-20 pubmed
    ..normal water intake, urinary osmolality (Uosm), plasma Na concentration, urine volume, and renal aquaporin-2 (AQP2) levels were unchanged, but plasma AVP concentration was reduced in CD ET-1 KO animals...
  5. Gattone V, Maser R, Tian C, Rosenberg J, Branden M. Developmental expression of urine concentration-associated genes and their altered expression in murine infantile-type polycystic kidney disease. Dev Genet. 1999;24:309-18 pubmed
    ..arginine vasopressin V2 receptors (AVP-V2R), and 3) the presence of appropriate CD water channels (aquaporins, AQP 2 and 3). An increase in urine osmolarity, normally seen between 1 and 3 weeks of age, was absent in cpk cystic mice...
  6. Krane C, Towne J, Menon A. Cloning and characterization of murine Aqp5: evidence for a conserved aquaporin gene cluster. Mamm Genome. 1999;10:498-505 pubmed
    ..and physical mapping genomic fragments contiguous with Aqp5 revealed two other members of the aquaporin family: Aqp2 and Aqp6, arrayed head to tail in the order Aqp2-Aqp5-Aqp6, and provides evidence of a gene cluster conserved in ..
  7. Jeong H, Jeon U, Koo B, Kim W, Im S, Shin J, et al. Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mice. J Clin Invest. 2009;119:3290-300 pubmed publisher
    ....
  8. Rojek A, Füchtbauer E, Kwon T, Frøkiaer J, Nielsen S. Severe urinary concentrating defect in renal collecting duct-selective AQP2 conditional-knockout mice. Proc Natl Acad Sci U S A. 2006;103:6037-42 pubmed
    Aquaporin-2 (AQP2) is the predominant vasopressin-regulated water channel in kidney connecting tubule (CNT) and collecting duct (CD) and is essential for renal regulation of body water balance...
  9. Nedvetsky P, Tabor V, Tamma G, Beulshausen S, Skroblin P, Kirschner A, et al. Reciprocal regulation of aquaporin-2 abundance and degradation by protein kinase A and p38-MAP kinase. J Am Soc Nephrol. 2010;21:1645-56 pubmed publisher
    Arginine-vasopressin (AVP) modulates the water channel aquaporin-2 (AQP2) in the renal collecting duct to maintain homeostasis of body water...
  10. Veikkolainen V, Naillat F, Railo A, Chi L, Manninen A, Hohenstein P, et al. ErbB4 modulates tubular cell polarity and lumen diameter during kidney development. J Am Soc Nephrol. 2012;23:112-22 pubmed publisher
    ..Taken together, these data suggest that ErbB4 signaling modulates proliferation and polarization, cellular functions critical for the development of epithelial ducts in the kidney. ..

Detail Information

Publications62

  1. Moeller H, Praetorius J, Rützler M, Fenton R. Phosphorylation of aquaporin-2 regulates its endocytosis and protein-protein interactions. Proc Natl Acad Sci U S A. 2010;107:424-9 pubmed publisher
    The water channel aquaporin-2 (AQP2) is essential for urine concentration. Vasopressin regulates phosphorylation of AQP2 at four conserved serine residues at the COOH-terminal tail (S256, S261, S264, and S269)...
  2. Moeller H, Knepper M, Fenton R. Serine 269 phosphorylated aquaporin-2 is targeted to the apical membrane of collecting duct principal cells. Kidney Int. 2009;75:295-303 pubmed publisher
    ..We recently identified a novel form of aquaporin-2 that is phosphorylated at serine-269 (pS269-AQP2)...
  3. Yang B, Gillespie A, Carlson E, Epstein C, Verkman A. Neonatal mortality in an aquaporin-2 knock-in mouse model of recessive nephrogenic diabetes insipidus. J Biol Chem. 2001;276:2775-9 pubmed
    Hereditary non-X-linked nephrogenic diabetes insipidus (NDI) is caused by mutations in the aquaporin-2 (AQP2) water channel...
  4. Ge Y, Ahn D, Stricklett P, Hughes A, Yanagisawa M, Verbalis J, et al. Collecting duct-specific knockout of endothelin-1 alters vasopressin regulation of urine osmolality. Am J Physiol Renal Physiol. 2005;288:F912-20 pubmed
    ..normal water intake, urinary osmolality (Uosm), plasma Na concentration, urine volume, and renal aquaporin-2 (AQP2) levels were unchanged, but plasma AVP concentration was reduced in CD ET-1 KO animals...
  5. Gattone V, Maser R, Tian C, Rosenberg J, Branden M. Developmental expression of urine concentration-associated genes and their altered expression in murine infantile-type polycystic kidney disease. Dev Genet. 1999;24:309-18 pubmed
    ..arginine vasopressin V2 receptors (AVP-V2R), and 3) the presence of appropriate CD water channels (aquaporins, AQP 2 and 3). An increase in urine osmolarity, normally seen between 1 and 3 weeks of age, was absent in cpk cystic mice...
  6. Krane C, Towne J, Menon A. Cloning and characterization of murine Aqp5: evidence for a conserved aquaporin gene cluster. Mamm Genome. 1999;10:498-505 pubmed
    ..and physical mapping genomic fragments contiguous with Aqp5 revealed two other members of the aquaporin family: Aqp2 and Aqp6, arrayed head to tail in the order Aqp2-Aqp5-Aqp6, and provides evidence of a gene cluster conserved in ..
  7. Jeong H, Jeon U, Koo B, Kim W, Im S, Shin J, et al. Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mice. J Clin Invest. 2009;119:3290-300 pubmed publisher
    ....
  8. Rojek A, Füchtbauer E, Kwon T, Frøkiaer J, Nielsen S. Severe urinary concentrating defect in renal collecting duct-selective AQP2 conditional-knockout mice. Proc Natl Acad Sci U S A. 2006;103:6037-42 pubmed
    Aquaporin-2 (AQP2) is the predominant vasopressin-regulated water channel in kidney connecting tubule (CNT) and collecting duct (CD) and is essential for renal regulation of body water balance...
  9. Nedvetsky P, Tabor V, Tamma G, Beulshausen S, Skroblin P, Kirschner A, et al. Reciprocal regulation of aquaporin-2 abundance and degradation by protein kinase A and p38-MAP kinase. J Am Soc Nephrol. 2010;21:1645-56 pubmed publisher
    Arginine-vasopressin (AVP) modulates the water channel aquaporin-2 (AQP2) in the renal collecting duct to maintain homeostasis of body water...
  10. Veikkolainen V, Naillat F, Railo A, Chi L, Manninen A, Hohenstein P, et al. ErbB4 modulates tubular cell polarity and lumen diameter during kidney development. J Am Soc Nephrol. 2012;23:112-22 pubmed publisher
    ..Taken together, these data suggest that ErbB4 signaling modulates proliferation and polarization, cellular functions critical for the development of epithelial ducts in the kidney. ..
  11. Guttman J, Samji F, Li Y, Deng W, Lin A, Finlay B. Aquaporins contribute to diarrhoea caused by attaching and effacing bacterial pathogens. Cell Microbiol. 2007;9:131-41 pubmed
    ..rodentium infection may alter AQP localization in colonocytes. We demonstrate that during infection, AQP2 and AQP3 are mislocalized from their normal location along cell membranes to the cell cytoplasm...
  12. Jouret F, Auzanneau C, Debaix H, Wada G, Pretto C, Marbaix E, et al. Ubiquitous and kidney-specific subunits of vacuolar H+-ATPase are differentially expressed during nephrogenesis. J Am Soc Nephrol. 2005;16:3235-46 pubmed
    ..They provide new insights into the complex regulation of V-ATPase subunits, the maturation of IC along the nephron, and the pathophysiology of hereditary dRTA. ..
  13. Saigusa T, Reichert R, Guare J, Siroky B, Gooz M, Steele S, et al. Collecting duct cells that lack normal cilia have mislocalized vasopressin-2 receptors. Am J Physiol Renal Physiol. 2012;302:F801-8 pubmed publisher
    ..This is the site where vasopressin (AVP) stimulates vasopressin-2 receptor (V2R)-mediated aquaporin-2 (AQP2) insertion into the apical membrane...
  14. Hasler U, Nielsen S, Feraille E, Martin P. Posttranscriptional control of aquaporin-2 abundance by vasopressin in renal collecting duct principal cells. Am J Physiol Renal Physiol. 2006;290:F177-87 pubmed
    Prevailing expression levels of aquaporin-2 (AQP2) mRNA play a major role in regulating AQP2 protein abundance. Here, we investigated whether AQP2 protein abundance is regulated at a posttranscriptional level as well...
  15. Grassmeyer J, Mukherjee M, deRiso J, Hettinger C, Bailey M, Sinha S, et al. Elf5 is a principal cell lineage specific transcription factor in the kidney that contributes to Aqp2 and Avpr2 gene expression. Dev Biol. 2017;424:77-89 pubmed publisher
    ..factors, including Elf5, Elf3 and Ehf, increase the transcriptional activity of the proximal promoters of Aqp2 and Avpr2 in cultured ureteric duct cell lines...
  16. van Balkom B, Boone M, Hendriks G, Kamsteeg E, Robben J, Stronks H, et al. LIP5 interacts with aquaporin 2 and facilitates its lysosomal degradation. J Am Soc Nephrol. 2009;20:990-1001 pubmed publisher
    ..binding to the V2 receptor in renal principal cells leads to activation of protein kinase A, phosphorylation of aquaporin 2 (AQP2) at Ser256, and the translocation of AQP2 to the apical membrane, resulting in concentration of the urine...
  17. Wildman S, Boone M, Peppiatt Wildman C, Contreras Sanz A, King B, Shirley D, et al. Nucleotides downregulate aquaporin 2 via activation of apical P2 receptors. J Am Soc Nephrol. 2009;20:1480-90 pubmed publisher
    ..Basolateral exposure to dDAVP induced AQP2 localization to the apical membrane, but co-treatment with ATP internalized AQP2...
  18. Lee S, Lee Y, Yoon J, Kang D, Lee H. Effect of Poria cocos on hypertonic stress-induced water channel expression and apoptosis in renal collecting duct cells. J Ethnopharmacol. 2012;141:368-76 pubmed publisher
    A major physiological role of the kidney is to regulate body water and urine concentration. Aquaporin-2 (AQP2), a family of water channels, plays an important role in the urinary concentrating process and regulation of water balance in ..
  19. Yasuoka Y, Kobayashi M, Sato Y, Nonoguchi H, Tanoue A, Okamoto H, et al. Decreased expression of aquaporin 2 in the collecting duct of mice lacking the vasopressin V1a receptor. Clin Exp Nephrol. 2013;17:183-90 pubmed publisher
    ..Am J Physiol 295: F100-7, 2008). Water balance, plasma vasopressin, plasma and urine osmolality, and aquaporin 2 (AQP2) expression in the kidney of wild-type (WT) and V1aR(-/-) mice were therefore further examined using ..
  20. Kong K, Park S, Park H, Kim M. A novel gene, Jpk, induces apoptosis in F9 murine teratocarcinoma cell through ROS generation. Ann N Y Acad Sci. 2003;1010:433-6 pubmed
    A novel gene Jpk (Jopock) has been originally isolated through yeast 1 hybridization technique as a trans-acting factor interacting with the position-specific regulatory element of a murine Hoxa-7...
  21. Srichai M, Colleta H, Gewin L, Matrisian L, Abel T, Koshikawa N, et al. Membrane-type 4 matrix metalloproteinase (MT4-MMP) modulates water homeostasis in mice. PLoS ONE. 2011;6:e17099 pubmed publisher
    ..Thus, our results show that although MT4-MMP is expressed in the kidney, this metalloproteinase does not play a major role in renal development or function; however it does appear to modify the neural stimuli that modulate thirst. ..
  22. Merves M, Bobbitt B, Parker K, Kishore B, Choo D. Developmental expression of aquaporin 2 in the mouse inner ear. Laryngoscope. 2000;110:1925-30 pubmed
    ..The objective of the present study was to define the developmental temporal and spatial expression pattern of aquaporin 2 (Aqp2) in the developing mouse inner ear...
  23. LeMaire S, Raghuram V, Grady C, Pickering C, Chou C, Umejiego E, et al. Serine/threonine phosphatases and aquaporin-2 regulation in renal collecting duct. Am J Physiol Renal Physiol. 2017;312:F84-F95 pubmed publisher
    Phosphorylation of the aquaporin-2 (AQP2) water channel at four COOH-terminal serines plays a central role in the regulation of water permeability of the renal collecting duct...
  24. Gilbert M, Yang L, Su T, McKnight G. Expression of a dominant negative PKA mutation in the kidney elicits a diabetes insipidus phenotype. Am J Physiol Renal Physiol. 2015;308:F627-38 pubmed publisher
    ..RIαB mice displayed a marked deficit in urinary concentrating ability and greatly reduced levels of AQP2 and phospho-AQP2...
  25. Arystarkhova E, Bouley R, Liu Y, Sweadner K. Impaired AQP2 trafficking in Fxyd1 knockout mice: A role for FXYD1 in regulated vesicular transport. PLoS ONE. 2017;12:e0188006 pubmed publisher
    ..of urine volume occurs in the inner medullary collecting duct (IMCD), chiefly mediated by the water channel aquaporin 2 (AQP2)...
  26. Sequeira Lopez M, Nagalakshmi V, Li M, Sigmund C, Gomez R. Vascular versus tubular renin: role in kidney development. Am J Physiol Regul Integr Comp Physiol. 2015;309:R650-7 pubmed publisher
    ..Further, the main source of circulating renin is the kidney vasculature. ..
  27. Merigo F, Mucignat Caretta C, Cristofoletti M, Zancanaro C. Epithelial membrane transporters expression in the developing to adult mouse vomeronasal organ and olfactory mucosa. Dev Neurobiol. 2011;71:854-69 pubmed publisher
    ..Results showed that CC26, cAMP-activated chloride channel (CFTR), and the water channel protein aquaporin 2, 3, 4, and 5 (AQP2, AQP3, AQP4, and AQP5) are expressed in developing to adult chemosensory epithelia with ..
  28. Suda S, Rai T, Sohara E, Sasaki S, Uchida S. Postnatal expression of KLF12 in the inner medullary collecting ducts of kidney and its trans-activation of UT-A1 urea transporter promoter. Biochem Biophys Res Commun. 2006;344:246-52 pubmed
    ..By comparing the AQP2 immunolocalization in sequential sections, KLF12 was found to be expressed in the collecting ducts...
  29. Tokuda M, Fujisawa M, Miyashita K, Kawakami Y, Morimoto Yamashita Y, Torii M. Involvement of TRPV1 and AQP2 in hypertonic stress by xylitol in odontoblast cells. Connect Tissue Res. 2015;56:44-9 pubmed publisher
    ..OLCs expressed TRPV1, 3 and 4 as well as AQP2. Xylitol inhibited lipopolysaccharide (LPS)-induced IL-6 expression after 3 h of hypertonic stress...
  30. Yang B, Zhao D, Verkman A. Hsp90 inhibitor partially corrects nephrogenic diabetes insipidus in a conditional knock-in mouse model of aquaporin-2 mutation. FASEB J. 2009;23:503-12 pubmed publisher
    Mutations in aquaporin-2 (AQP2) that interfere with its cellular processing can produce autosomal recessive nephrogenic diabetes insipidus (NDI)...
  31. Nechiporuk T, Fernandez T, Vasioukhin V. Failure of epithelial tube maintenance causes hydrocephalus and renal cysts in Dlg5-/- mice. Dev Cell. 2007;13:338-50 pubmed
    ..These findings show that Dlg5 is causally involved in hydrocephalus and renal cysts and reveal that targeted membrane delivery of cadherin-catenin adhesion complexes is critical for cell polarity and epithelial tube maintenance. ..
  32. Moeller H, MacAulay N, Knepper M, Fenton R. Role of multiple phosphorylation sites in the COOH-terminal tail of aquaporin-2 for water transport: evidence against channel gating. Am J Physiol Renal Physiol. 2009;296:F649-57 pubmed publisher
    Arginine vasopressin (AVP)-regulated phosphorylation of the water channel aquaporin-2 (AQP2) at serine 256 (S256) is essential for its accumulation in the apical plasma membrane of collecting duct principal cells...
  33. Jung H, Kim S, Choi H, Park E, Lim J, Frøkiaer J, et al. Tankyrase-mediated β-catenin activity regulates vasopressin-induced AQP2 expression in kidney collecting duct mpkCCDc14 cells. Am J Physiol Renal Physiol. 2015;308:F473-86 pubmed publisher
    Aquaporin-2 (AQP2) mediates arginine vasopressin (AVP)-induced water reabsorption in the kidney collecting duct. AVP regulates AQP2 expression primarily via Gsα/cAMP/PKA signaling...
  34. Felszeghy S, Modis L, Nemeth P, Nagy G, Zelles T, Agre P, et al. Expression of aquaporin isoforms during human and mouse tooth development. Arch Oral Biol. 2004;49:247-57 pubmed
    ..b>AQP2, AQP3 and AQP9 immunoreactivity was not observed in tooth germs, whereas strong AQP4 and AQP5 expression was ..
  35. Deen P. Mouse models for congenital nephrogenic diabetes insipidus: what can we learn from them?. Nephrol Dial Transplant. 2007;22:1023-6 pubmed
  36. Yang B, Ma T, Xu Z, Verkman A. cDNA and genomic cloning of mouse aquaporin-2: functional analysis of an orthologous mutant causing nephrogenic diabetes insipidus. Genomics. 1999;57:79-83 pubmed
    ..a transgenic mouse model of nephrogenic diabetes insipidus (NDI), we have analyzed the mouse aquaporin-2 (Aqp2) cDNA and gene and generated a mutated Aqp2 orthologous to NDI-causing human AQP2-T126M...
  37. Hatem Vaquero M, Griera M, Giermakowska W, Luengo A, Calleros L, Gonzalez Bosc L, et al. Integrin linked kinase regulates the transcription of AQP2 by NFATC3. Biochim Biophys Acta. 2017;1860:922-935 pubmed publisher
    Two processes are associated with progressive loss of renal function: 1) decreased aquaporin-2 (AQP2) expression and urinary concentrating capacity (Nephrogenic Diabetes Insipidus, NDI); and 2) changes in extracellular matrix (ECM) ..
  38. Centrone M, Ranieri M, Di Mise A, Berlingerio S, Russo A, Deen P, et al. AQP2 Abundance is Regulated by the E3-Ligase CHIP Via HSP70. Cell Physiol Biochem. 2017;44:515-531 pubmed publisher
    b>AQP2 expression is mainly controlled by vasopressin-dependent changes in protein abundance which is in turn regulated by AQP2 ubiquitylation and degradation, however the proteins involved in these processes are largely unknown...
  39. Yang B, Zhao D, Qian L, Verkman A. Mouse model of inducible nephrogenic diabetes insipidus produced by floxed aquaporin-2 gene deletion. Am J Physiol Renal Physiol. 2006;291:F465-72 pubmed
    ..ability produced by deletion of various membrane transport or receptor proteins, including aquaporin-2 (AQP2), are associated with neonatal mortality from polyuria...
  40. Rai T, Uchida S, Marumo F, Sasaki S. Cloning of rat and mouse aquaporin-2 gene promoters and identification of a negative cis-regulatory element. Am J Physiol. 1997;273:F264-73 pubmed
    ..These results indicate that tissue-specific expression of AQP-2 gene may in part be regulated by this novel negative acting cis-element...
  41. Hasler U, Mordasini D, Bianchi M, Vandewalle A, Feraille E, Martin P. Dual influence of aldosterone on AQP2 expression in cultured renal collecting duct principal cells. J Biol Chem. 2003;278:21639-48 pubmed
    ..We have previously shown that endogenous expression of the aquaporin-2 (AQP2) water channel in immortalized mouse cortical CD principal cells (mpkCCDC14) grown on filters is dramatically ..
  42. Georgas K, Rumballe B, Wilkinson L, Chiu H, Lesieur E, Gilbert T, et al. Use of dual section mRNA in situ hybridisation/immunohistochemistry to clarify gene expression patterns during the early stages of nephron development in the embryo and in the mature nephron of the adult mouse kidney. Histochem Cell Biol. 2008;130:927-42 pubmed publisher
    ..We have analysed in detail the protein expression of Wt1, Calb1 Aqp1, Aqp2 and Umod using these antibodies...
  43. Sohara E, Rai T, Yang S, Uchida K, Nitta K, Horita S, et al. Pathogenesis and treatment of autosomal-dominant nephrogenic diabetes insipidus caused by an aquaporin 2 mutation. Proc Natl Acad Sci U S A. 2006;103:14217-22 pubmed
    Frame-shift mutations within the C terminus of aquaporin 2 (AQP2) cause autosomal-dominant nephrogenic diabetes insipidus (AD-NDI)...
  44. MARCIANO D, BRAKEMAN P, Lee C, Spivak N, Eastburn D, Bryant D, et al. p120 catenin is required for normal renal tubulogenesis and glomerulogenesis. Development. 2011;138:2099-109 pubmed publisher
    ..Taken together, our data show that p120ctn is required for early tubule and glomerular morphogenesis, as well as control of luminal diameter, probably through regulation of cadherins. ..
  45. Werth M, Walentin K, Aue A, Schönheit J, Wuebken A, Pode Shakked N, et al. The transcription factor grainyhead-like 2 regulates the molecular composition of the epithelial apical junctional complex. Development. 2010;137:3835-45 pubmed publisher
    ..Together, our data provide evidence that Grhl2 acts as a target gene-associated transcriptional activator of apical junctional complex components and, thereby, crucially participates in epithelial differentiation. ..
  46. Trac D, Liu B, Pao A, Thomas S, Park M, Downs C, et al. Fulvene-5 inhibition of Nadph oxidases attenuates activation of epithelial sodium channels in A6 distal nephron cells. Am J Physiol Renal Physiol. 2013;305:F995-F1005 pubmed publisher
    ....
  47. Yu L, Moriguchi T, Souma T, Takai J, Satoh H, Morito N, et al. GATA2 regulates body water homeostasis through maintaining aquaporin 2 expression in renal collecting ducts. Mol Cell Biol. 2014;34:1929-41 pubmed publisher
    ..Upon purification of the GFP-positive cells, we found that collecting duct (CD)-specific markers, including aquaporin 2 (Aqp2), an important channel for water reabsorption from urine, were abundantly expressed...
  48. Kim D, Wang M, Cai Q, Brooks H, Dressler G. Pax transactivation-domain interacting protein is required for urine concentration and osmotolerance in collecting duct epithelia. J Am Soc Nephrol. 2007;18:1458-65 pubmed
    ..Furthermore, aquaporin-2 (AQP2) expression in the inner medulla of the ptip knockout mice was decreased approximately 10-fold compared with that ..
  49. Procino G, Barbieri C, Tamma G, De Benedictis L, Pessin J, Svelto M, et al. AQP2 exocytosis in the renal collecting duct -- involvement of SNARE isoforms and the regulatory role of Munc18b. J Cell Sci. 2008;121:2097-106 pubmed publisher
    Vasopressin regulates the fusion of the water channel aquaporin 2 (AQP2) to the apical membrane of the renal collecting-duct principal cells and several lines of evidence indicate that SNARE proteins mediate this process...
  50. Moeller H, Fuglsang C, Pedersen C, Fenton R. Basolateral cholesterol depletion alters Aquaporin-2 post-translational modifications and disrupts apical plasma membrane targeting. Biochem Biophys Res Commun. 2018;495:157-162 pubmed publisher
    Apical plasma membrane accumulation of the water channel Aquaporin-2 (AQP2) in kidney collecting duct principal cells is critical for body water homeostasis...
  51. Hoffert J, Nielsen J, Yu M, Pisitkun T, Schleicher S, Nielsen S, et al. Dynamics of aquaporin-2 serine-261 phosphorylation in response to short-term vasopressin treatment in collecting duct. Am J Physiol Renal Physiol. 2007;292:F691-700 pubmed
    ..site, serine-261 (pS261), in the COOH-terminus of the vasopressin-regulated water channel, aquaporin-2 (AQP2)...
  52. Whiteman E, Fan S, Harder J, Walton K, Liu C, Soofi A, et al. Crumbs3 is essential for proper epithelial development and viability. Mol Cell Biol. 2014;34:43-56 pubmed publisher
    ..Taken together, our data indicate that Crumbs3 is crucial for epithelial morphogenesis and plays a role in linking the apical membrane to the underlying ezrin-containing cytoskeleton. ..
  53. Mao Y, Mulvaney J, Zakaria S, Yu T, Morgan K, Allen S, et al. Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development. Development. 2011;138:947-57 pubmed publisher
    ..Our analysis implies that Dchs1 and Fat4 function as a ligand-receptor pair during murine development, and identifies novel requirements for Dchs1-Fat4 signaling in multiple organs. ..
  54. Jiang S, Chiou Y, Wang E, Lin H, Lin Y, Chi Y, et al. Defining a link with autosomal-dominant polycystic kidney disease in mice with congenitally low expression of Pkd1. Am J Pathol. 2006;168:205-20 pubmed
    ..Abnormalities in Na(+)/K(+)-ATPase, aquaporin-2, and vasopressin V2 receptor expression were also identified. This mouse model may be suitable for further studies of progression and therapeutic interventions of ADPKD. ..
  55. Offenberg H, Barcroft L, Caveney A, Viuff D, Thomsen P, Watson A. mRNAs encoding aquaporins are present during murine preimplantation development. Mol Reprod Dev. 2000;57:323-30 pubmed
    ..These findings predict that AQPs may function as conduits for trophectoderm fluid transport during blastocyst formation. ..
  56. Guo L, Alli A, Eaton D, Bao H. ENaC is regulated by natriuretic peptide receptor-dependent cGMP signaling. Am J Physiol Renal Physiol. 2013;304:F930-7 pubmed publisher
    ....
  57. Hashemolhosseini S, Hadjihannas M, Stolt C, Haas C, Amann K, Wegner M. Restricted expression of mouse GCMa/Gcm1 in kidney and thymus. Mech Dev. 2002;118:175-8 pubmed
    ..In thymus, mGCMa is restricted to few small clusters of cells, in kidney to the S3 segment of proximal tubules. mGCMa expression is primarily postnatal, arguing for a role in organ function rather than organ development. ..
  58. Edashige K, Sakamoto M, Kasai M. Expression of mRNAs of the aquaporin family in mouse oocytes and embryos. Cryobiology. 2000;40:171-5 pubmed
    ..These aquaporins may play a role in water transport and conceivably also in cryoprotectant transport across the plasma membrane in these cells...
  59. Pietilä I, Ellwanger K, Railo A, Jokela T, Barrantes I, Shan J, et al. Secreted Wnt antagonist Dickkopf-1 controls kidney papilla development coordinated by Wnt-7b signalling. Dev Biol. 2011;353:50-60 pubmed publisher
    ..Based on the results, we propose that Dkk1 controls the degree of Wnt-7b signalling in the papilla to coordinate kidney organogenesis. ..
  60. Hocherl K, Schmidt C, Kurt B, Bucher M. Inhibition of NF-kappaB ameliorates sepsis-induced downregulation of aquaporin-2/V2 receptor expression and acute renal failure in vivo. Am J Physiol Renal Physiol. 2010;298:F196-204 pubmed publisher
    ..CLP caused a time-dependent downregulation of renal vasopressin V(2) receptor and of AQP2 expression without alterations in plasma vasopressin levels...
  61. Nagy I, Xu Q, Naillat F, Ali N, Miinalainen I, Samoylenko A, et al. Impairment of Wnt11 function leads to kidney tubular abnormalities and secondary glomerular cystogenesis. BMC Dev Biol. 2016;16:30 pubmed publisher
    ..The C57Bl6 Wnt11 (-/-) mouse generated here provides a model for studying the mechanisms behind tubular anomalies and glomerular cyst formation. ..
  62. Klein J, Sands J, Qian L, Wang X, Yang B. Upregulation of urea transporter UT-A2 and water channels AQP2 and AQP3 in mice lacking urea transporter UT-B. J Am Soc Nephrol. 2004;15:1161-7 pubmed
    ..reverse transcription-PCR and Northern blot analysis showed upregulation of the UT-A2 urea transporter and the aquaporin 2 (AQP2) and AQP3 water channel transcripts but no change in other urea transporters or AQP...