Avil

Summary

Gene Symbol: Avil
Description: advillin
Alias: Advil, DOC6, advillin, actin-binding protein DOC6, p92
Species: mouse

Top Publications

  1. ncbi Type F scavenger receptor SREC-I interacts with advillin, a member of the gelsolin/villin family, and induces neurite-like outgrowth
    Mami Shibata
    Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 279:40084-90. 2004
  2. pmc Pain without nociceptors? Nav1.7-independent pain mechanisms
    Michael S Minett
    Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Cell Rep 6:301-12. 2014
  3. ncbi Analyzing somatosensory axon projections with the sensory neuron-specific Advillin gene
    Hiroshi Hasegawa
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 27:14404-14. 2007
  4. pmc Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway
    Xiang Zhou
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 107:9424-9. 2010
  5. pmc A role for Piezo2 in EPAC1-dependent mechanical allodynia
    N Eijkelkamp
    Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK
    Nat Commun 4:1682. 2013
  6. pmc Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons
    Michael S Minett
    Molecular Nociception Group, WIBR UCL, Gower Street, London WC1E 6BT, UK
    Nat Commun 3:791. 2012
  7. pmc Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain
    Hao Jui Weng
    Departments of Neuroscience and Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA Department of Dermatology, National Taiwan University Hospital, Taipei City 100, Taiwan
    Neuron 85:833-46. 2015
  8. pmc A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier
    Tammy Szu Yu Ho
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, USA
    Nat Neurosci 17:1664-72. 2014
  9. pmc Significant determinants of mouse pain behaviour
    Michael S Minett
    Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, Gower Street, London, United Kingdom
    PLoS ONE 9:e104458. 2014
  10. pmc Mapping sensory circuits by anterograde transsynaptic transfer of recombinant rabies virus
    Niccolo Zampieri
    Departments of Neuroscience and Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Kavli Institute for Brain Science, Columbia University, New York, NY 10032 USA
    Neuron 81:766-78. 2014

Scientific Experts

  • Niels Eijkelkamp
  • D J Kwiatkowski
  • P W Marks
  • S Raisa Eng
  • Thorsten Buch
  • Michael S Minett
  • Fan Wang
  • John N Wood
  • Hiroshi Hasegawa
  • Fumiyasu Imai
  • Jennifer R Leslie
  • David D Ginty
  • Bao Xia Han
  • YingXin Zhang-Hooks
  • Yuhao Zhang
  • Kalina K Stantcheva
  • Lauren L Orefice
  • Hao Jui Weng
  • Yongcheol Cho
  • Cédric Peirs
  • Ying Xiao
  • Sonia Santana-Varela
  • Yury D Bogdanov
  • Tammy Szu Yu Ho
  • Niccolo Zampieri
  • Daniel R Zollinger
  • Tilat A Rizvi
  • Matthew N Rasband
  • Yutaka Yoshida
  • Promila Pagadala
  • Mohammed A Nassar
  • Chuansheng Zhang
  • Eric S McCoy
  • Valeria Cavalli
  • Hawon Cho
  • Yin Liu
  • Rotem Ben Tov Perry
  • Avraham Yaron
  • Alexandra Scott
  • Xiang Zhou
  • Namiko Abe
  • Wenqin Luo
  • S Raisa Eng
  • Jacky Guy
  • Mami Shibata
  • Masayoshi Mishina
  • Xin Duan
  • David R Ladle
  • Joshua P Head
  • Linda Nocchi
  • Amanda L Zimmerman
  • Steven J Sleboda
  • Daniel Bilbao
  • Triantafillos Paparountas
  • Yi Zheng
  • Paul A Heppenstall
  • Dwight E Bergles
  • Amit Agarwal
  • Shao Rui Chen
  • Hong Chen
  • Geoffroy Laumet
  • Emerald Perlas
  • Rahul Dhandapani
  • Hui Lin Pan
  • Anda M Chirila
  • Loredana Iovino
  • Carla Portulano
  • Fernanda de Castro Reis
  • Martina Pesaresi
  • Kalyanee S Shirlekar
  • Concepción Martínez
  • Laura Castaldi
  • Georgianne M Ciraolo
  • Rebecca P Seal
  • Jung Eun Shin
  • Natalie E Cagle
  • Stéphane Lolignier
  • Wangyuan Zou
  • Vinod Tiwari
  • Yixun Geng
  • Queensta Millet
  • Gian D Iannetti
  • Qin Zheng
  • Xinzhong Dong
  • Nathaniel A Jeske
  • James J Cox
  • Jeremy Y Gedeon
  • Daniel T Thoresen
  • Isaac Brownell
  • Alexandros H Kanellopoulos

Detail Information

Publications35

  1. ncbi Type F scavenger receptor SREC-I interacts with advillin, a member of the gelsolin/villin family, and induces neurite-like outgrowth
    Mami Shibata
    Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 279:40084-90. 2004
    ..The SREC-I-mediated morphological change required the cytoplasmic domain of the protein, and we identified advillin, a member of the gelsolin/villin family of actin regulatory proteins, as a protein binding to this domain...
  2. pmc Pain without nociceptors? Nav1.7-independent pain mechanisms
    Michael S Minett
    Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Cell Rep 6:301-12. 2014
    ..8-positive nociceptors. Thus, similar pain phenotypes arise through distinct cellular and molecular mechanisms. Therefore, rational analgesic drug therapy requires patient stratification in terms of mechanisms and not just phenotype...
  3. ncbi Analyzing somatosensory axon projections with the sensory neuron-specific Advillin gene
    Hiroshi Hasegawa
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 27:14404-14. 2007
    ..We found that the gene encoding Advillin, an actin binding protein that belongs to the gelsolin superfamily, is expressed almost exclusively in peripheral ..
  4. pmc Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway
    Xiang Zhou
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 107:9424-9. 2010
    ..Our studies represent in vivo characterization of PIK3C3 functions in mammals and provide insights into the complexity of neuronal endo-lysosomal and autophagic pathways...
  5. pmc A role for Piezo2 in EPAC1-dependent mechanical allodynia
    N Eijkelkamp
    Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK
    Nat Commun 4:1682. 2013
    ..These data indicate that the Epac1-Piezo2 axis has a role in the development of mechanical allodynia during neuropathic pain...
  6. pmc Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons
    Michael S Minett
    Molecular Nociception Group, WIBR UCL, Gower Street, London WC1E 6BT, UK
    Nat Commun 3:791. 2012
    ..Ablating Nav1.7 gene (SCN9A) expression in all sensory neurons using Advillin-Cre abolishes mechanical pain, inflammatory pain and reflex withdrawal responses to heat...
  7. pmc Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain
    Hao Jui Weng
    Departments of Neuroscience and Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA Department of Dermatology, National Taiwan University Hospital, Taipei City 100, Taiwan
    Neuron 85:833-46. 2015
    ..Our study unveils a context-dependent modulation of the TRPA1-V1 complex, and Tmem100-3Q CPP is a promising pain therapy...
  8. pmc A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier
    Tammy Szu Yu Ho
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, USA
    Nat Neurosci 17:1664-72. 2014
    ....
  9. pmc Significant determinants of mouse pain behaviour
    Michael S Minett
    Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, Gower Street, London, United Kingdom
    PLoS ONE 9:e104458. 2014
    ..Failure to conduct behavioural tests at different anatomical locations, stimulus intensities, and at different points in the circadian cycle may lead to a pain behavioural phenotype being misinterpreted, or missed altogether. ..
  10. pmc Mapping sensory circuits by anterograde transsynaptic transfer of recombinant rabies virus
    Niccolo Zampieri
    Departments of Neuroscience and Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Kavli Institute for Brain Science, Columbia University, New York, NY 10032 USA
    Neuron 81:766-78. 2014
    ..Anterograde transsynaptic transfer is a feature shared by other classes of primary sensory neurons, permitting the identification and potentially the manipulation of neural circuits processing sensory feedback within the mammalian CNS. ..
  11. pmc Membrane domain organization of myelinated axons requires βII spectrin
    Chuansheng Zhang
    Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030
    J Cell Biol 203:437-43. 2013
    ..Thus, the paranodal spectrin-based submembranous cytoskeleton comprises the paranodal barriers required for myelinated axon domain organization. ..
  12. pmc Loss of NR1 subunit of NMDARs in primary sensory neurons leads to hyperexcitability and pain hypersensitivity: involvement of Ca(2+)-activated small conductance potassium channels
    Promila Pagadala
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 33:13425-30. 2013
    ..To address this problem, we used Advillin-Cre driver to delete the NR1 subunit of NMDARs selectively in DRG neurons...
  13. pmc Neural Hedgehog signaling maintains stem cell renewal in the sensory touch dome epithelium
    Ying Xiao
    Dermatology Branch, Center of Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 112:7195-200. 2015
    ..These findings demonstrate that nerve-derived Shh is a critical regulator of lineage-specific stem cells that maintain specialized sensory compartments in the epidermis. ..
  14. pmc Sexually dimorphic BDNF signaling directs sensory innervation of the mammary gland
    Yin Liu
    The Solomon H Snyder Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 338:1357-60. 2012
    ..Thus, sex hormone regulation of a neurotrophic factor signal directs sexually dimorphic axonal growth and maintenance, resulting in generation of a sex-specific neural circuit...
  15. pmc Subcellular knockout of importin β1 perturbs axonal retrograde signaling
    Rotem Ben Tov Perry
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    Neuron 75:294-305. 2012
    ..Thus, localized translation of Importin β1 mRNA enables separation of cytoplasmic and nuclear transport functions of importins and is required for efficient retrograde signaling in injured axons...
  16. pmc Dorsal Horn Circuits for Persistent Mechanical Pain
    Cédric Peirs
    Departments of Neurobiology and Otolaryngology, University of Pittsburgh School of Medicine, 3501 Fifth Avenue, BST3, Pittsburgh, PA 15213, USA Pittsburgh Center for Pain Research, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Neuron 87:797-812. 2015
    ..Lastly, using inflammatory and neuropathic pain models, we show that multiple microcircuits in the dorsal horn encode this form of pain...
  17. pmc Activating Injury-Responsive Genes with Hypoxia Enhances Axon Regeneration through Neuronal HIF-1α
    Yongcheol Cho
    Department of Anatomy and Neurobiology, School of Medicine, Washington University in St Louis, St Louis, MO 63110, USA
    Neuron 88:720-34. 2015
    ..This study demonstrates that HIF-1α represents a critical transcriptional regulator in regenerating neurons and suggests hypoxia as a tool to stimulate axon regeneration...
  18. pmc Endogenous opioids contribute to insensitivity to pain in humans and mice lacking sodium channel Nav1.7
    Michael S Minett
    Molecular Nociception Group, WIBR, University College London, Gower Street, London WC1E 6BT, UK
    Nat Commun 6:8967. 2015
    ..7-null mutant mice, as well as in a human Nav1.7-null mutant. These data suggest that Nav1.7 channel blockers alone may not replicate the analgesic phenotype of null mutant humans and mice, but may be potentiated with exogenous opioids. ..
  19. pmc NMDA Receptors Enhance Spontaneous Activity and Promote Neuronal Survival in the Developing Cochlea
    YingXin Zhang-Hooks
    Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 89:337-50. 2016
    ..Loss of NMDAR signaling from SGNs reduced their survival both in vivo and in vitro, revealing that spontaneous activity in the prehearing cochlea promotes maturation of auditory circuitry through periodic activation of NMDARs in SGNs. ..
  20. pmc Nerve Injury Diminishes Opioid Analgesia through Lysine Methyltransferase-mediated Transcriptional Repression of μ-Opioid Receptors in Primary Sensory Neurons
    Yuhao Zhang
    From the Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas 77030
    J Biol Chem 291:8475-85. 2016
    ..G9a inhibitors may be used to enhance the opioid analgesic effect in the treatment of chronic neuropathic pain. ..
  21. ncbi Reversal of neurological defects in a mouse model of Rett syndrome
    Jacky Guy
    Wellcome Trust Centre for Cell Biology, Edinburgh University, King s Buildings, Edinburgh EH9 3JR, UK
    Science 315:1143-7. 2007
    ....
  22. pmc A subpopulation of itch-sensing neurons marked by Ret and somatostatin expression
    Kalina K Stantcheva
    EMBL Mouse Biology Unit, Monterotondo, Italy
    EMBO Rep 17:585-600. 2016
    ..generating mice in which the diphtheria toxin receptor is conditionally expressed from the sensory neuron-specific Avil locus. Sst-Cre::Avil(iDTR) mice display normal nociceptive responses to thermal and mechanical stimuli...
  23. ncbi A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration
    Thorsten Buch
    Laboratory for Molecular Immunology, Institute for Genetics, University of Cologne, D 50931 Cologne, Germany
    Nat Methods 2:419-26. 2005
    ..Notably, we show that the developing DT-specific antibody response is weak and not neutralizing, and thus does not impede the efficacy of DT. Our results validate the use of iDTR mice as a tool for cell ablation in vivo...
  24. pmc Synapse Formation in Monosynaptic Sensory-Motor Connections Is Regulated by Presynaptic Rho GTPase Cdc42
    Fumiyasu Imai
    Division of Developmental Biology
    J Neurosci 36:5724-35. 2016
    ....
  25. doi Peripheral Mechanosensory Neuron Dysfunction Underlies Tactile and Behavioral Deficits in Mouse Models of ASDs
    Lauren L Orefice
    Department of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Cell 166:299-313. 2016
    ..Thus, mechanosensory processing defects contribute to anxiety-like behavior and social interaction deficits in ASD mouse models. PAPERCLIP. ..
  26. pmc Peptidergic CGRPα primary sensory neurons encode heat and itch and tonically suppress sensitivity to cold
    Eric S McCoy
    Department of Cell Biology and Physiology, UNC Neuroscience Center, The University of North Carolina at Chapel Hill, CB 7545, Chapel Hill, NC 27599, USA
    Neuron 78:138-51. 2013
    ..Disruption of this crosstalk unmasks cold hypersensitivity, with mechanistic implications for neuropathic pain and temperature perception...
  27. doi The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons
    Hawon Cho
    Sensory Research Center, Creative Research Initiatives, College of Pharmacy, Seoul National University, Seoul, Republic of Korea
    Nat Neurosci 15:1015-21. 2012
    ..These results indicate that ANO1 is a heat sensor that detects nociceptive thermal stimuli in sensory neurons and possibly mediates nociception...
  28. pmc Identification of novel stress-induced genes downstream of chop
    X Z Wang
    Skirball Institute of Biomolecular Medicine, the Departments of Medicine, Cell Biology and the Kaplan Cancer Center, NYU Medical Center, New York, NY 10016, USA
    EMBO J 17:3619-30. 1998
    ..is a mammalian ortholog of a Drosophila gene, Tenm/Odz, implicated in patterning of the early fly embryo, whereas DOC6 encodes a newly recognized homolog of the actin-binding proteins villin and gelsolin...
  29. pmc Ectopic myelinating oligodendrocytes in the dorsal spinal cord as a consequence of altered semaphorin 6D signaling inhibit synapse formation
    Jennifer R Leslie
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Development 138:4085-95. 2011
    ..Our findings provide new insights into the relationship between oligodendrocytes and synapse formation in vivo, which might be an important element in controlling the development of neural wiring in the central nervous system...
  30. pmc Transcription factor short stature homeobox 2 is required for proper development of tropomyosin-related kinase B-expressing mechanosensory neurons
    Alexandra Scott
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 31:6741-9. 2011
    ..Together, our findings identify Shox2 as an essential but not sufficient component of the transcription programs required in neural progenitor cells for the proper specification of subsets of TrkB-expressing touch/mechanosensory neurons...
  31. pmc Mammalian target of rapamycin (mTOR) activation increases axonal growth capacity of injured peripheral nerves
    Namiko Abe
    Department of Anatomy and Neurobiology, Washington University in St Louis, School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 285:28034-43. 2010
    ..Thus, whereas manipulation of mTOR activity could provide new strategies to stimulate nerve regeneration in the PNS, fine control of mTOR activity is required for proper target innervation...
  32. pmc Molecular identification of rapidly adapting mechanoreceptors and their developmental dependence on ret signaling
    Wenqin Luo
    Solomon H Snyder Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2185, USA
    Neuron 64:841-56. 2009
    ..Thus, the early Ret(+) neurons are RA mechanoreceptors and Ret signaling is required for the assembly of neural circuits underlying touch perception...
  33. pmc POU-domain factor Brn3a regulates both distinct and common programs of gene expression in the spinal and trigeminal sensory ganglia
    S Raisa Eng
    Department of Psychiatry, University of California, San Diego and VA San Diego Healthcare System, Gilman Drive, La Jolla, CA 92093 0603, USA
    Neural Dev 2:3. 2007
    ..Although these ganglia have similar functions, they have distinct embryological origins, in that both contain neurons originating from the neural crest, while only the TG includes cells derived from the placodal ectoderm...
  34. ncbi Functions of gelsolin: motility, signaling, apoptosis, cancer
    D J Kwiatkowski
    Genetics Laboratory Hematology Division Brigham and Women s Hospital 221 Longwood Avenue Boston MA 02115 USA
    Curr Opin Cell Biol 11:103-8. 1999
    ..Gelsolin is an obligate downstream effector of Rac for motility in dermal fibroblasts, regulates phosphoinositide signaling pathways and ion channel function in vivo, and acts as both a regulator and effector of apoptosis...
  35. ncbi Advillin (p92): a new member of the gelsolin/villin family of actin regulatory proteins
    P W Marks
    Division of Experimental Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Cell Sci 111:2129-36. 1998
    ..The predicted amino acid sequence of the 92 kDa murine protein p92 (advillin) is 75% homologous to villin and 65% homologous to gelsolin and adseverin...