Genomes and Genes
Gene Symbol: Bdnf
Description: brain derived neurotrophic factor
Alias: brain-derived neurotrophic factor
Publications177 found, 100 shown here
- Critical role of promoter IV-driven BDNF transcription in GABAergic transmission and synaptic plasticity in the prefrontal cortexKazuko Sakata
Section on Neural Development and Plasticity, National Institute of Child Health and Human Development, National Institutes of Health, 35 Lincoln Drive, Bethesda, MD 20892 3714, USA
Proc Natl Acad Sci U S A 106:5942-7. 2009Transcription of Bdnf is controlled by multiple promoters, which drive expression of multiple transcripts encoding for the same protein...
- Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalitiesW E Lyons
Neural Development Group, Advanced BioScience Laboratories Basic Research Program, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
Proc Natl Acad Sci U S A 96:15239-44. 1999Brain-derived neurotrophic factor (BDNF) has trophic effects on serotonergic (5-HT) neurons in the central nervous system...
- BDNF regulates eating behavior and locomotor activity in miceS G Kernie
Center for Developmental Biology, U T Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75235 9133, USA
EMBO J 19:1290-300. 2000Brain-derived neurotrophic factor (BDNF) was studied initially for its role in sensory neuron development...
- Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivityM Rios
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Mol Endocrinol 15:1748-57. 2001..Our results demonstrate that brain derived neurotrophic factor has an essential maintenance function in the regulation of anxiety-related behavior and in food ..
- DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulationKeri Martinowich
Neuroscience Interdepartmental Program, UCLA School of Medicine, 760 Westwood Plaza, Los Angeles, CA 90095, USA
Science 302:890-3. 2003..We report that increased synthesis of brain-derived neurotrophic factor (BDNF) in neurons after depolarization correlates with a decrease in CpG methylation within the regulatory region of the ..
- Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brainM Hofer
Max Planck Institute for Psychiatry, Department of Neurochemistry, Martinsried, FRG
EMBO J 9:2459-64. 1990Brain-derived neurotrophic factor (BDNF) is a protein that allows the survival of specific neuronal populations...
- A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavoneSung Wuk Jang
Department of Pathology, Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Proc Natl Acad Sci U S A 107:2687-92. 2010Brain-derived neurotrophic factor (BDNF), a cognate ligand for the tyrosine kinase receptor B (TrkB) receptor, mediates neuronal survival, differentiation, synaptic plasticity, and neurogenesis...
- Global deprivation of brain-derived neurotrophic factor in the CNS reveals an area-specific requirement for dendritic growthStefanie Rauskolb
Biozentrum, University of Basel, CH 4056 Basel, Switzerland
J Neurosci 30:1739-49. 2010Although brain-derived neurotrophic factor (BDNF) is linked with an increasing number of conditions causing brain dysfunction, its role in the postnatal CNS has remained difficult to assess...
- Mice with reduced brain-derived neurotrophic factor expression show decreased choline acetyltransferase activity, but regular brain monoamine levels and unaltered emotional behaviorSabine Chourbaji
Central Institut of Mental Health Mannheim CIMA, University of Heidelberg, Mannheim J 5 D 68159, Germany
Brain Res Mol Brain Res 121:28-36. 2004..disorders in humans coincide with a decreased activity and/or expression of brain-derived neurotrophic factor (BDNF) in the brain...
- Control of hyperphagia prevents obesity in BDNF heterozygous miceVincenzo Coppola
Neural Development Group, Mouse Cancer Genetics Program, National Cancer Institute, 7th Street, Bldg 560 Rm 32 31D, P O Box B, Frederick, MD 21702, USA
Neuroreport 15:2665-8. 2004Reduced levels of BDNF in mice cause obesity and behavioral abnormalities including increased aggression and hyperactivity...
- Uptake and recycling of pro-BDNF for transmitter-induced secretion by cortical astrocytesMatteo Bergami
Department of Human and General Physiology, University of Bologna, I 40126 Bologna, Italy
J Cell Biol 183:213-21. 2008Activity-dependent secretion of brain-derived neurotrophic factor (BDNF) is thought to enhance synaptic plasticity, but the mechanisms controlling extracellular availability and clearance of secreted BDNF are poorly understood...
- Involvement of brain-derived neurotrophic factor (BDNF) in MP4-induced autoimmune encephalomyelitisSita Javeri
Department of Anatomy, University of Cologne, Joseph Stelzmann Str 9, 50931 Cologne, Germany
Clin Immunol 137:181-9. 2010The role of brain-derived neurotrophic factor (BDNF) in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE) is still unclear...
- Brain-derived neurotrophic factor is required for the maintenance of cortical dendritesJessica A Gorski
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
J Neurosci 23:6856-65. 2003Brain-derived neurotrophic factor (BDNF) is thought to be involved in neuronal survival, migration, morphological and biochemical differentiation, and modulation of synaptic function in the CNS...
- Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticityPetti T Pang
Section on Neural Development and Plasticity, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development NICHD, Bethesda, MD 20892, USA
Science 306:487-91. 2004..Two secretory proteins, tissue plasminogen activator (tPA) and brain-derived neurotrophic factor (BDNF), have been implicated in this process, but their relationship is unclear...
- Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrusMikko Sairanen
Neuroscience Center, University of Helsinki, 00014 Helsinki, Finland
J Neurosci 25:1089-94. 2005..increase proliferation of neuronal progenitor cells and expression of brain-derived neurotrophic factor (BDNF) in the hippocampus...
- Mice lacking brain-derived neurotrophic factor develop with sensory deficitsP Ernfors
Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142
Nature 368:147-50. 1994..Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, can prevent the death of particular peripheral sensory neurons in vitro, and ..
- Localization of brain-derived neurotrophic factor to distinct terminals of mossy fiber axons implies regulation of both excitation and feedforward inhibition of CA3 pyramidal cellsSteve C Danzer
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Neurosci 24:11346-55. 2004..This mossy fiber pathway contains the highest concentration of brain-derived neurotrophic factor (BDNF) in the CNS, yet whether BDNF is positioned to regulate the excitatory and/or inhibitory pathways is unknown...
- Expression of brain-derived neurotrophic factor and TrkB neurotrophin receptors after striatal injury in the mouseJ Y Wong
Department of Neurology, University of Melbourne, Austin, Australia
Exp Neurol 148:83-91. 1997Brain-derived neurotrophic factor (BDNF) promotes the survival and differentiation of nigral dopaminergic neurons and supports the activity of dopaminergic cells grafted into the striatum...
- Variant brain-derived neurotrophic factor (Val66Met) alters adult olfactory bulb neurogenesis and spontaneous olfactory discriminationKevin G Bath
Department of Psychiatry, Weill Medical College of Cornell University, New York, New York 10065, USA
J Neurosci 28:2383-93. 2008Neurogenesis, the division, migration, and differentiation of new neurons, occurs throughout life. Brain derived neurotrophic factor (BDNF) has been identified as a potential signaling molecule regulating neurogenesis in the ..
- Prelimbic cortical BDNF is required for memory of learned fear but not extinction or innate fearDennis C Choi
Department of Psychiatry and Behavioral Sciences, Howard Hughes Medical Institute, Center for Behavioral Neuroscience, Emory University School of Medicine, Atlanta, GA 30322, USA
Proc Natl Acad Sci U S A 107:2675-80. 2010..deletion, and pharmacological rescue with a TrkB agonist, we examined the role of a primary candidate mechanism, BDNF, in conditioned fear...
- BDNF and TrkB in neuronal differentiation of Fmr1-knockout mouseVerna Louhivuori
Department of Biomedicine Physiology, University of Helsinki, PO Box 63, FIN 00014 Helsinki, Finland
Neurobiol Dis 41:469-80. 2011..Brain-derived neurotrophic factor (BDNF) and its TrkB receptors play a central role in neuronal maturation and plasticity...
- Endogenous proBDNF is a negative regulator of migration of cerebellar granule cells in neonatal miceZhi Qiang Xu
Department of Human Physiology, Flinders University, Adelaide, SA 5001, Australia
Eur J Neurosci 33:1376-84. 2011..Migration of cerebellar granule cells (CGCs) requires multiple factors. Mature brain-derived neurotrophic factor (BDNF) positively regulates the proliferation, migration, survival and differentiation of CGCs in rodents...
- Mouse and rat BDNF gene structure and expression revisitedTamara Aid
Department of Gene Technology, Tallinn University of Technology, Tallinn, Estonia
J Neurosci Res 85:525-35. 2007Brain-derived neurotrophic factor (BDNF) has important functions in the development of the nervous system and in brain plasticity-related processes such as memory, learning, and drug addiction...
- Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memoriesS A Heldt
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
Mol Psychiatry 12:656-70. 2007Brain-derived neurotrophic factor (BDNF) is known to play a critical role in the synaptic plasticity underlying the acquisition and/or consolidation of certain forms of memory...
- Nociceptor-derived brain-derived neurotrophic factor regulates acute and inflammatory but not neuropathic painJing Zhao
Molecular Nociception Group, Department of Biology, University College London, London WC1E 6BT, UK
Mol Cell Neurosci 31:539-48. 2006..Here, we used the Cre-loxP system to delete BDNF in most nociceptive sensory neurons. Conditional null animals were healthy with no sensory neuron loss...
- Heterozygous knock-out mice for brain-derived neurotrophic factor show a pathway-specific impairment of long-term potentiation but normal critical period for monocular deprivationAlessandro Bartoletti
Scuola Normale Superiore, Laboratorio di Neurobiologia, 56100 Pisa, Italy
J Neurosci 22:10072-7. 2002Genetic deletion of a single allele of the BDNF gene affects hippocampal LTP and causes several behavioral phenotypes, including deficits in spatial learning...
- Huntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and releaseLinda Lin Yan Wu
Department of Human Physiology and Centre for Neuroscience, Flinders University, GPO Box 2100, Adelaide, South Australia 5001, Australia
J Biol Chem 285:5614-23. 2010Brain-derived neurotrophic factor (BDNF) plays a pivotal role in brain development and synaptic plasticity...
- The role of neurotrophin receptors in female germ-cell survival in mouse and humanNorah Spears
Biomedical Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
Development 130:5481-91. 2003..showed that mRNA encoding TrkB and its two ligands, neurotrophin 4 (NT4) and brain-derived neurotrophic factor (BDNF), were present throughout the period of follicle formation in the mouse...
- Specificity and timing of neocortical transcriptome changes in response to BDNF gene ablation during embryogenesis or adulthoodC Glorioso
Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15261, USA
Mol Psychiatry 11:633-48. 2006Brain-derived neurotrophic factor (BDNF) has been reported to be critical for the development of cortical inhibitory neurons...
- Differential expression of BDNF mRNA splice variants in mouse brain and immune cellsNiels Kruse
Institute for Multiple Sclerosis Research, Medical Faculty of University of Göttingen and Gemeinnützige Hertie Stiftung, Waldweg 33, 37073 Gottingen, Germany
J Neuroimmunol 182:13-21. 2007For the neurotrophin BDNF several splice variants were recently described. We analyzed the expression of mBDNF mRNA splice variants in cells of the immune system in comparison to the central nervous system (CNS)...
- Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapseDanielle L Graham
Department of Psychiatry, The Seay Center for Basic and Applied Research in Psychiatric Illness, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
Nat Neurosci 10:1029-37. 2007..intravenous cocaine self-administration in rats induced a transient increase in brain-derived neurotrophic factor (BDNF) and activation of TrkB-mediated signaling in the nucleus accumbens (NAc)...
- Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNFTomoya Matsumoto
Biozentrum, University of Basel, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
Nat Neurosci 11:131-3. 2008Pro- and mature BDNF activate very different receptors and intracellular pathways, potentially leading to either neuronal death or survival...
- Canal cristae growth and fiber extension to the outer hair cells of the mouse ear require Prox1 activityBernd Fritzsch
Department of Biology, University of Iowa, Iowa City, Iowa, United States of America
PLoS ONE 5:e9377. 2010..The homeobox gene Prox1 is required for lens, retina, pancreas, liver, and lymphatic vasculature development and is expressed in inner ear supporting cells and neurons...
- Hippocampal enlargement in Bassoon-mutant mice is associated with enhanced neurogenesis, reduced apoptosis, and abnormal BDNF levelsAlexandra Heyden
Department for Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, Magdeburg, Germany
Cell Tissue Res 346:11-26. 2011..and of other forebrain structures was accompanied by increased levels of brain-derived neurotrophic factor (BDNF)...
- Genetic modulation of BDNF signaling affects the outcome of axonal competition in vivoLuxiang Cao
Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Curr Biol 17:911-21. 2007..However, the molecular pathways that modulate axonal-branch stability or formation in competitive environments remain unknown...
- Early striatal dendrite deficits followed by neuron loss with advanced age in the absence of anterograde cortical brain-derived neurotrophic factorZachary C Baquet
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
J Neurosci 24:4250-8. 2004Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, modulates neuronal survival, differentiation, and synaptic function...
- Brain-derived neurotrophic factor regulates the maturation of layer 4 fast-spiking cells after the second postnatal week in the developing barrel cortexChiaki Itami
Division of Biochemistry and Cellular Biology, National Institute of Neuroscience, Tokyo 187 8502, Japan
J Neurosci 27:2241-52. 2007Brain-derived neurotrophic factor (BDNF) has been reported to play a critical role in modulating plasticity in developing sensory cortices...
- Wheel running and environmental enrichment differentially modify exon-specific BDNF expression in the hippocampus of wild-type and pre-motor symptomatic male and female Huntington's disease miceM S Zajac
Howard Florey Institute, Florey Neuroscience Institutes, University of Melbourne, Parkville, Vic, Australia
Hippocampus 20:621-36. 2010Brain-derived neurotrophic factor (BDNF) is an essential neurotrophin and regulation of its expression is complex due to multiple 5' untranslated exons which are separately spliced to a common coding exon to form unique mRNA transcripts...
- A changing pattern of brain-derived neurotrophic factor expression correlates with the rearrangement of fibers during cochlear development of rats and miceB Wiechers
Department of Oto Rhino Laryngology, University of Tubingen, D 72076 Tubingen, Germany
J Neurosci 19:3033-42. 1999..We observed a spatiotemporal change in the localization of brain-derived neurotrophic factor (BDNF) protein and mRNA, which correlated with the reorganization of fibers...
- Knocking the NT4 gene into the BDNF locus rescues BDNF deficient mice and reveals distinct NT4 and BDNF activitiesG Fan
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
Nat Neurosci 3:350-7. 2000To directly compare biological activities of the neurotrophins NT4 and BDNF in vivo, we replaced the BDNF coding sequence with the NT4 sequence in mice (Bdnfnt4-ki)...
- Presynaptic BDNF required for a presynaptic but not postsynaptic component of LTP at hippocampal CA1-CA3 synapsesStanislav S Zakharenko
Center for Neurobiology and Behavior, Columbia University, 722 West 168th Street, New York, NY 10032, USA
Neuron 39:975-90. 2003Brain-derived neurotrophic factor (BDNF) has been implicated in several forms of long-term potentiation (LTP) at different hippocampal synapses...
- Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathwayZhe Yu Chen
Department of Psychiatry, Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
J Neurosci 25:6156-66. 2005Brain-derived neurotrophic factor (BDNF), after activity-dependent secretion from neurons, modulates critical nervous system functions...
- Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor familyP Ernfors
Department of Medical Chemistry, Karolinska Institute, Stockholm, Sweden
Neuron 5:511-26. 1990Cells expressing mRNA for hippocampus-derived neurotrophic factor (HDNF/NT-3) or brain-derived neurotrophic factor (BDNF) were identified by in situ hybridization...
- Sensory but not motor neuron deficits in mice lacking NT4 and BDNFX Liu
Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142, USA
Nature 375:238-41. 1995..Neurotrophin-4 (NT4), alone or in combination with brain-derived neurotrophic factor (BDNF), has been suggested to be necessary for the survival of peripheral sensory neurons and central nervous system (CNS)..
- Degeneration of vestibular neurons in late embryogenesis of both heterozygous and homozygous BDNF null mutant miceL M Bianchi
Regeneron Pharmaceuticals Inc, Tarrytown, NY 10591, USA
Development 122:1965-73. 1996..among developing cochlear or vestibular neurons for available amounts of either brain-derived neurotrophic factor (BDNF) or neurotrophin-4/5 (NT-4/5). Both cochlear and vestibular neurons were present in mice lacking NT-4/5...
- Synaptic innervation density is regulated by neuron-derived BDNFC G Causing
Center for Neuronal Survival, Montreal Neurological Institute, McGill University, Canada
Neuron 18:257-67. 1997In this report, we have examined the role of neuron-derived BDNF at an accessible synapse, that of preganglionic neurons onto their sympathetic neuron targets...
- The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron deathS X Bamji
Center for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
J Cell Biol 140:911-23. 1998..survival is maintained with low quantities of NGF or KCl, the neurotrophin brain-derived neurotrophic factor (BDNF), which does not activate Trk receptors on sympathetic neurons, causes neuronal apoptosis and increased ..
- FGF/FGFR-2(IIIb) signaling is essential for inner ear morphogenesisU Pirvola
Institute of Biotechnology and Department of Otorhinolaryngology, University of Helsinki, 00014 Helsinki, Finland
J Neurosci 20:6125-34. 2000..Our findings provide genetic evidence that signaling by FGFR-2(IIIb) is critical for the morphological development of the inner ear...
- NeuroD-null mice are deaf due to a severe loss of the inner ear sensory neurons during developmentW Y Kim
Department of Molecular Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
Development 128:417-26. 2001....
- BDNF but not NT-4 is required for normal flexion reflex plasticity and functionP A Heppenstall
Growth Factors and Regeneration Group, Department of Neuroscience, Max Delbruck Center for Molecular Medicine, D 13092 Berlin, Germany
Proc Natl Acad Sci U S A 98:8107-12. 2001..Brain-derived neurotrophic factor (BDNF) might be released by nociceptors onto spinal neurons and mediate central sensitization associated with chronic ..
- Spatial shaping of cochlear innervation by temporally regulated neurotrophin expressionI Farinas
Program in Neuroscience, Department of Physiology and Howard Hughes Medical Institute, University of California, San Francisco, California 94143 0724, USA
J Neurosci 21:6170-80. 2001..of the deficit in the NT-3 mutant to the spatial-temporal expression patterns of brain-derived neurotrophic factor (BDNF) and NT-3, using lacZ reporters in each gene and with expression of the specific neurotrophin receptors, trkB and ..
- Learning deficits in forebrain-restricted brain-derived neurotrophic factor mutant miceJ A Gorski
Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Boulder, CO 80309, USA
Neuroscience 121:341-54. 2003Brain-derived neurotrophic factor (BDNF) participates in synaptic plasticity and the adaptive changes in the strength of communication between neurons thought to underlie aspects of behavioral adaptation...
- Relationship of brain-derived neurotrophic factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophreniaTakanori Hashimoto
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Neurosci 25:372-83. 2005..We investigated the involvement of signaling mediated by brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase TrkB in producing the altered GABA-related gene expression in schizophrenia...
- REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesisNurit Ballas
Howard Hughes Medical Institute, Dept of Neurology and Behavior, The State University of New York at Stony Brook, Stony Brook, NY 11794, USA
Cell 121:645-57. 2005..Thus, a multistage repressor mechanism controls the orderly expression of genes during development while still permitting fine tuning in response to specific stimuli...
- Brain-derived neurotrophic factor modulates dopaminergic deficits in a transgenic mouse model of Huntington's diseaseJose R Pineda
Departament de Biologia Cel lular i Anatomia Patològica, Facultat de Medicina, Universitat de Barcelona, Spain
J Neurochem 93:1057-68. 2005..Here, we study the role of brain-derived neurotrophic factor (BDNF) in alterations of the nigrostriatal system associated with transgenics carrying mutant huntingtin...
- Smaller inner ear sensory epithelia in Neurog 1 null mice are related to earlier hair cell cycle exitV Matei
Department of Biomedical Science, Creighton University, Omaha, Nebraska 68178, USA
Dev Dyn 234:633-50. 2005..Neurog 1 null mice show a truncation of clonal expansion of hair cell precursors through temporally altered terminal mitosis, thereby resulting in smaller sensory epithelia...
- A disorganized innervation of the inner ear persists in the absence of ErbB2Jacqueline K Morris
Department of Biology and Geology, Baldwin Wallace College, Berea, OH 44017, USA
Brain Res 1091:186-99. 2006..null mice retain afferents to inner hair cells possibly because of the prominent expression of the neurotrophin Bdnf in developing hair cells...
- Disruption of a novel regulatory locus results in decreased Bdnf expression, obesity, and type 2 diabetes in miceHaibo Sha
Model Animal Research Center, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China
Physiol Genomics 31:252-63. 2007Mutants of brain-derived neurotrophic factor (BDNF) are associated with obesity. However, the regulatory mechanism of BDNF expression is still unclear...
- Genetic increase in brain-derived neurotrophic factor levels enhances learning and memoryYukako Nakajo
Laboratory for Cerebrovascular Disorders, Research Institute of National Cardio Vascular Center, Suita, Osaka 565 8565, Japan
Brain Res 1241:103-9. 2008Brain-derived neurotrophic factor (BDNF), a neurotrophin, is known to promote neuronal differentiation stimulating neurite outgrowth in the developing CNS, and is also known to modulate synaptic plasticity, thereby contributing to ..
- Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factorM Korte
Max Planck Institut fur Psychiatrie, Munich Martinsried, Germany
Proc Natl Acad Sci U S A 92:8856-60. 1995Brain-derived neurotrophic factor (BDNF), a member of the nerve growth factor (NGF) gene family, has been shown to influence the survival and differentiation of specific classes of neurons in vitro and in vivo...
- Complementary roles of BDNF and NT-3 in vestibular and auditory developmentP Ernfors
Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142, USA
Neuron 14:1153-64. 1995The physiological role of BDNF and NT-3 in the development of the vestibular and auditory systems was investigated in mice that carry a deleted BDNF and/or NT-3 gene...
- Suppressed epileptogenesis in BDNF mutant miceM Kokaia
Department of Neurology, University Hospital, Lund, Sweden
Exp Neurol 133:215-24. 1995..kindling epileptogenesis causes a marked, transient increase of the synthesis of brain-derived neurotrophic factor (BDNF) in cortical and hippocampal neurons...
- Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron developmentK R Jones
Howard Hughes Medical Institute University of California, San Francisco School of Medicine 94143
Cell 76:989-99. 1994Brain-derived neurotrophic factor (BDNF), a neurotrophin, enhances the survival and differentiation of several classes of neurons in vitro. To determine its essential functions, we have mutated the BDNF gene...
- Absence of sensory neurons before target innervation in brain-derived neurotrophic factor-, neurotrophin 3-, and TrkC-deficient embryonic miceD J Liebl
Developmental Biology Center, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9133, USA
J Neurosci 17:9113-21. 1997..We have analyzed embryonic and neonatal mice with mutations in the BDNF, neurotrophin 3 (NT-3), and TrkC genes...
- Learning deficit in BDNF mutant miceS Linnarsson
Department of Molecular Neurobiology, Karolinska Institute, Stockholm, Sweden
Eur J Neurosci 9:2581-7. 1997Brain-derived neurotrophic factor (BDNF) has been implicated in the regulation of high-frequency synaptic transmission and long-term potentiation in the hippocampus, processes that are also thought to be involved in the learning of ..
- Neurotrophin 4 is required for the survival of a subclass of hair follicle receptorsC L Stucky
Department of Neurology, University of Wurzburg, D 97080 Wurzburg, Germany
J Neurosci 18:7040-6. 1998..Previous studies have shown that BDNF is required for the mechanical sensitivity of slowly adapting (SA) mechanoreceptors but not for the postnatal ..
- BDNF overexpression induces differential increases among subsets of sympathetic innervation in murine back skinV A Botchkarev
Department of Dermatology, Charite, Humboldt University Berlin, Germany
Eur J Neurosci 10:3276-83. 1998..investigated the sympathetic innervation of back skin in mice overexpressing brain-derived neurotrophic factor (BDNF) under the alpha-myosin heavy-chain promoter, as well as in BDNF knockout (-/-) mice...
- Impairments in high-frequency transmission, synaptic vesicle docking, and synaptic protein distribution in the hippocampus of BDNF knockout miceL D Pozzo-Miller
Laboratory of Neurobiology, National Institute of Neurological Diseases and Stroke NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 19:4972-83. 1999Brain-derived neurotrophic factor (BDNF) promotes long-term potentiation (LTP) at hippocampal CA1 synapses by a presynaptic enhancement of synaptic transmission during high-frequency stimulation (HFS)...
- BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortexZ J Huang
Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
Cell 98:739-55. 1999..of the visual cortex in transgenic mice in which the postnatal rise of brain-derived neurotrophic factor (BDNF) was accelerated. In these mice, the maturation of GABAergic innervation and inhibition was accelerated...
- Epithelial overexpression of BDNF or NT4 disrupts targeting of taste neurons that innervate the anterior tongueR F Krimm
Department of Pathology and Laboratory Medicine, University of Kentucky Medical Center, Lexington, Kentucky 40536 0298, USA
Dev Biol 232:508-21. 2001Brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT4) are essential for the survival of geniculate ganglion neurons, which provide the sensory afferents for taste buds of the anterior tongue and palate...
- Evaluation of nigrostriatal dopaminergic function in adult +/+ and +/- BDNF mutant miceD E Dluzen
Department of Anatomy, Northeastern Ohio Universities College of Medicine NEOUCOM, Rootstown, Ohio 44272, USA
Exp Neurol 170:121-8. 2001Deletion of a single copy of the BDNF gene has been shown to affect the nigrostriatal dopaminergic system of young adult BDNF mice...
- Dissection of NT3 functions in vivo by gene replacement strategyV Coppola
Neural Development Group, Mouse Cancer Genetics Program, NCI, Frederick, MD 21701, USA
Development 128:4315-27. 2001..receptor interactions in vivo, we have replaced the Nt3 gene with the gene for brain-derived neurotrophic factor (BDNF), a TrkB ligand. As in NT3 and TrkC null mice, the proprioception system of these mutants failed to assemble...
- BDNF stimulates migration of cerebellar granule cellsPaul R Borghesani
Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
Development 129:1435-42. 2002..of cerebellar granule cells out of their proliferative zone, the external granule cell layer (EGL), is impaired in Bdnf(-/-) mice. The reason for impaired migration is that BDNF directly and acutely stimulates granule cell migration...
- Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult miceJaewon Lee
Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, Baltimore, Maryland 21224, USA
J Neurochem 82:1367-75. 2002To determine the role of brain-derived neurotrophic factor (BDNF) in the enhancement of hippocampal neurogenesis resulting from dietary restriction (DR), heterozygous BDNF knockout (BDNF +/-) mice and wild-type mice were maintained for 3 ..
- BDNF gene replacement reveals multiple mechanisms for establishing neurotrophin specificity during sensory nervous system developmentKarin Agerman
Unit of Molecular Neurobiology, MBB, Karolinska Institutet, 171 77 Stockholm, Sweden
Development 130:1479-91. 2003..despite overlapping expression of TrkB and TrkC in many sensory ganglia, brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3) null mutant mice display selective losses in neuronal subpopulations...
- Brain-derived neurotrophic factor mediates activity-dependent dendritic growth in nonpyramidal neocortical interneurons in developing organotypic culturesXiaoming Jin
Department of Neurobiology and Anatomy, West Virginia University, Morgantown, West Virginia 26506 9128, USA
J Neurosci 23:5662-73. 2003Brain-derived neurotrophic factor (BDNF) promotes postnatal maturation of GABAergic inhibition in the cerebral and cerebellar cortices, and its expression and release are enhanced by neuronal activity, suggesting that it acts in a ..
- Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2Wen G Chen
Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
Science 302:885-9. 2003..We find that MeCP2 binds selectively to BDNF promoter III and functions to repress expression of the BDNF gene...
- Transgenic mice overexpressing the full-length neurotrophin receptor trkB exhibit increased activation of the trkB-PLCgamma pathway, reduced anxiety, and facilitated learningEija Koponen
Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland
Mol Cell Neurosci 26:166-81. 2004..TK+ mice. Altogether, overexpression of the trkB.TK+ receptor postnatally leads to selective activation of trkB signaling pathways and enhanced learning and memory...
- Essential role of brain-derived neurotrophic factor in adult hippocampal functionLisa M Monteggia
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
Proc Natl Acad Sci U S A 101:10827-32. 2004Brain-derived neurotrophic factor (BDNF) regulates neuronal development and function. However, it has been difficult to discern its role in the adult brain in influencing complex behavior...
- Late onset loss of hippocampal 5-HT and NE is accompanied by increases in BDNF protein expression in mice co-expressing mutant APP and PS1Matthew E Szapacs
Department of Chemistry and the Huck Institute for Life Sciences, The Pennsylvania State University, University Park, PA 16802 4615, USA
Neurobiol Dis 16:572-80. 2004..In addition, brain-derived neurotrophic factor (BDNF) protein levels were investigated since changes in BDNF are reported to occur in AD, and BDNF has been shown to ..
- Maturation but not survival of dopaminergic nigrostriatal neurons is affected in developing and aging BDNF-deficient miceSarah A Baker
Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY 40292, USA
Brain Res 1039:177-88. 2005Brain-derived neurotrophic factor (BDNF) promotes survival of injured dopaminergic nigrostriatal neurons of the adult rodent substantia nigra pars compacta, as well their development in vitro...
- Atoh1 null mice show directed afferent fiber growth to undifferentiated ear sensory epithelia followed by incomplete fiber retentionB Fritzsch
Creighton University, Department of Biomedical Sciences, Omaha, Nebraska 68178, USA
Dev Dyn 233:570-83. 2005..for growing afferent fibers, possibly through the release of the neurotrophin brain-derived neurotrophic factor (BDNF)...
- Presence of neurotrophic factors in skeletal muscle correlates with survival of spinal cord motor neuronsBoris Kablar
Dalhousie University, Faculty of Medicine, Department of Anatomy and Neurobiology, Halifax, Nova Scotia, Canada
Dev Dyn 234:659-69. 2005....
- Lingual deficits in neurotrophin double knockout miceIrina V Nosrat
Laboratory of Oral Neurobiology, Department of Biological and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA
J Neurocytol 33:607-15. 2004Brain-derived neurotrophic factor (BDNF) and Neurotrophin 3 (NT-3) are members of the neurotrophin family and are expressed in the developing and adult tongue papillae...
- Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviorsLisa M Monteggia
Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
Biol Psychiatry 61:187-97. 2007Indirect evidence suggests that loss of brain-derived neurotrophic factor (BDNF) from forebrain regions contributes to an individual's vulnerability for depression, whereas upregulation of BDNF in these regions is suggested to mediate the ..
- Regulation of preimplantation embryo development by brain-derived neurotrophic factorKazuhiro Kawamura
Department of Obstetrics and Gynecology, Akita University School of Medicine, Akita, 010 8543, Japan
Dev Biol 311:147-58. 2007..We found expression of brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5 (NT-4/5) transcripts at its highest levels in the blastocyst stages...
- Selective deletion of Bdnf in the ventromedial and dorsomedial hypothalamus of adult mice results in hyperphagic behavior and obesityThaddeus J Unger
Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
J Neurosci 27:14265-74. 2007Brain-derived neurotrophic factor (BDNF) and its receptor TrkB are expressed in several hypothalamic and hindbrain nuclei involved in regulating energy homeostasis, developmentally and in the adult animal...
- A model for neuronal competition during developmentChristopher D Deppmann
Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Science 320:369-73. 2008..We suggest that three target-initiated events are essential for rapid and robust competition between neurons: sensitization, paracrine apoptotic signaling, and protection from such effects...
- Developmental axon pruning mediated by BDNF-p75NTR-dependent axon degenerationKarun K Singh
Developmental and Stem Cell Biology, Hospital for Sick Children, 555 University Avenue, Toronto, Canada M5G 1X8
Nat Neurosci 11:649-58. 2008..which, during developmental sympathetic axon competition, winning axons secrete brain-derived neurotrophic factor (BDNF) in an activity-dependent fashion, which binds to the p75 neurotrophin receptor (p75NTR) on losing axons to cause ..
- A bi-directional carboxypeptidase E-driven transport mechanism controls BDNF vesicle homeostasis in hippocampal neuronsJoshua J Park
Section on Cellular Neurobiology, Developmental Neurobiology Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA
Mol Cell Neurosci 39:63-73. 2008Anterograde transport of brain-derived neurotrophic factor (BDNF) vesicles from the soma to neurite terminals is necessary for activity-dependent secretion of BDNF to mediate synaptic plasticity, memory and learning, and retrograde BDNF ..
- Distinct role of long 3' UTR BDNF mRNA in spine morphology and synaptic plasticity in hippocampal neuronsJuan Ji An
Department of Pharmacology, Georgetown University, Washington, DC 20057, USA
Cell 134:175-87. 2008The brain produces two brain-derived neurotrophic factor (BDNF) transcripts, with either short or long 3' untranslated regions (3' UTRs). The physiological significance of the two forms of mRNAs encoding the same protein is unknown...
- Depletion of central BDNF in mice impedes terminal differentiation of new granule neurons in the adult hippocampusJason P Chan
Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA
Mol Cell Neurosci 39:372-83. 2008..Here, we investigated the role of BDNF in facilitating their maturation in vivo...
- A biological function for the neuronal activity-dependent component of Bdnf transcription in the development of cortical inhibitionElizabeth J Hong
Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
Neuron 60:610-24. 2008..Here, we demonstrate that introduction of a subtle knockin mutation into the mouse Bdnf gene that blocks the ability of the activity-regulated factor CREB to bind Bdnf promoter IV results in an animal in ..
- Mouse olfactory ensheathing glia enhance axon outgrowth on a myelin substrate in vitroStephen A Runyan
Department of Physiological Science, UCLA, Los Angeles, CA 90095 1606, USA
Exp Neurol 216:95-104. 2009..if a cell adhesion molecule expressed by OEG, L1, and a factor secreted by OEG, brain-derived neurotrophic factor (BDNF), contribute to the ability of OEG to enhance axonal outgrowth on myelin...
- Neuronal release of proBDNFJianmin Yang
Department of Medicine, Weill Cornell Medical College, 1300 York Ave, New York, New York 10065, USA
Nat Neurosci 12:113-5. 2009Pro-brain-derived neurotrophic factor (proBDNF) and mature BDNF utilize distinct receptors to mediate divergent neuronal actions...
- Differential expression of neurotrophins in postnatal C57BL/6 mice striatumV Zermeño
Unidad de Biomedicina, FES I, Universidad Nacional Autonoma de Mexico, Av de los Barrios 1, Los Reyes Iztacala, C P 54090 Tlalnepantla, Mexico
Int J Biol Sci 5:118-27. 2009..In the present study, immunocytochemical expression of BDNF, NT-3 and NT-4/5 was characterized in striatal tissue of C57BL/6 mice at postnatal days 10(th )(P10), 21(st) (P21), ..
- Epithelial-derived brain-derived neurotrophic factor is required for gustatory neuron targeting during a critical developmental periodLiqun Ma
Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
J Neurosci 29:3354-64. 2009Brain-derived neurotrophic factor (BDNF) is expressed in epithelial targets of gustatory neurons (i.e...
- Gender-specific impact of brain-derived neurotrophic factor signaling on stress-induced depression-like behaviorAnita E Autry
Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
Biol Psychiatry 66:84-90. 2009..The neurotrophic hypothesis of depression suggests that loss of brain-derived neurotrophic factor (BDNF) may increase susceptibility for depression-like behavior, although direct evidence is lacking.
- Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer's diseaseShiyong Peng
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
J Neurosci 29:9321-9. 2009Downregulation of brain-derived neurotrophic factor (BDNF) in the cortex occurs early in the progression of Alzheimer's disease (AD)...
- Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer diseaseMathew Blurton-Jones
Department of Neurobiology and Behavior and Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA
Proc Natl Acad Sci U S A 106:13594-9. 2009..involves a robust enhancement of hippocampal synaptic density, mediated by brain-derived neurotrophic factor (BDNF). Gain-of-function studies show that recombinant BDNF mimics the beneficial effects of NSC transplantation...
- Dendritic trafficking of BDNF mRNA is mediated by translin and blocked by the G196A (Val66Met) mutationC Chiaruttini
BRAIN Centre for Neuroscience, Department of Life Sciences, and Dipartimento di Scienze Farmaceutiche, University of Trieste, 34127 Trieste, Italy
Proc Natl Acad Sci U S A 106:16481-6. 2009Alternatively spliced brain-derived neurotrophic factor (BDNF) transcripts are targeted to distinct cellular compartments in neurons but the mechanisms underlying this sorting are unknown...
- Genetic remodeling of Vagal Afferent OrganizationEdward Fox; Fiscal Year: 2009..innervate the gastrointestinal (Gl) tract in mice with a mutation in either the brain-derived neurotrophic factor (BDNF) gene or the neurotrophin-3 (NT-3) gene...
- Region & Developmental Stage Specific Deletion of MeCP2 in Mouse BrainLisa Monteggia; Fiscal Year: 2008..The proposed studies should increase our understanding of the role of MeCP2 in mediating certain RTT associated behaviors as well as identify neural circuits that mediate these abnormalities. [unreadable] [unreadable] [unreadable]..
- ROD NEURODEGENERATIVE AND PROTECTIVE GENESBaerbel Rohrer; Fiscal Year: 2005..However brain-derived neurotrophic factor (BDNF) and ciliary neurotrophic factor, the two most widely used factors, do not act on the photoreceptors directly, but ..
- EPIGENETIC CHANGES IN FRONTAL LOBE OF SCHIZOPHRENICSSchahram Akbarian; Fiscal Year: 2009....
- Genetic Analysis of Age Related Hearing ImpairmentRick A Friedman; Fiscal Year: 2010..This improved knowledge base can be anticipated to constitute fertile ground for developing new evidence-based preventive and therapeutic approaches to treating ARHI. ..
- GENE EXPRESSION IN NERVOUS TISSUEBruce S McEwen; Fiscal Year: 2010..abstract_text> ..
- DOPAMINERGIC SIGNALING MODIFIES STRATIAL HISTONESSchahram Akbarian; Fiscal Year: 2009....
- Brain Development Following InstitutionalizationBETTY CASEY; Fiscal Year: 2008..We will recruit a typically developing population of children to assess deviations or delays in the development of amygdala and hippocampal volume and function. [unreadable] [unreadable]..
- Proteoglycan degradation and functional recovery after peripheral nerve injuryARTHUR ENGLISH; Fiscal Year: 2007..This proposal seeks to evaluate a technology for medical treatment of peripheral nerve injuries which, if successful, could have an important impact on a relatively large group of under-treated patients. [unreadable] [unreadable]..
- Replacing an Animal Resource Facility Cage Washer.Kristen Drescher; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- 5HT transporter & 1A receptor function in BDNF miceJULIE HENSLER; Fiscal Year: 2007unreadable] DESCRIPTION (provided by applicant): Brain-derived neurotrophic factor (BDNF) promotes serotonergic neurotransmission and the structural plasticity of serotonergic (5rHT) neurons in the adult brain...
- DEVELOPMENT OF EFFERENT NERVE FIBERS IN THE COCHLEAHANNA SOBKOWICZ; Fiscal Year: 2001..plans to identify ultrastructurally the morphological and immunochemical character of vesiculated endings that express GAP-43 in the inner spiral bundle, the only neuronal pathway that contains this growth protein in the adult cochlea. ..
- Chromatin Pathology in Cerebral Cortex of SchizophrenicsSchahram Akbarian; Fiscal Year: 2006..Finally, the proposed studies will provide the framework for future proposals designed to map histone modification patterns across entire chromosomes in human brain, including alterations in major psychiatric disease. ..
- NEURAL PLASTICITY IN TASTEBruce Oakley; Fiscal Year: 2001..neurons and taste buds are affected by inactivation of genes for one or more of the neurotrophins NT-3, NT-4 and BDNF or their cognate tyrosine kinase receptors...
- NEUROTROPHINS IN NEURONAL SURVIVAL AND DIFFERENTIATIONXin Liu; Fiscal Year: 2004..Neurotrophins are a four-member family of structurally related proteins; Nerve Growth Factor (NGF), Brain Derived Neurotrophic Factor (BDNF), Neurotrophin-3 (NT-3) and Neurotrophin-4 (NT-4)...
- Muscle Gene Expression Biomarkers of HDAndrew Strand; Fiscal Year: 2006..This aim of this proposal is to develop muscle gene expression changes in HD biomarkers that will be more sensitive to disease progression than the current clinical rating scale. ..
- Frontostriatal Development and Cognitive ControlBETTY CASEY; Fiscal Year: 2005....
- Transgenic Rod Development and FunctionBaerbel Rohrer; Fiscal Year: 2005..However, more importantly, it will provide avenues for studying gene defects at the single cell level not only in the retina, but in other systems as well. ..
- Study of a genetic network involved in ear developmentRick Friedman; Fiscal Year: 2005..These and future experiments represent the natural progression from my Mentored Clinical Scientist Development Award (K08). ..
- Antigen Identification in Occult ChorioretinopathiesJeffrey Bennett; Fiscal Year: 2006....
- Inhibition of trkB Dephosphorylation: A Novel Approach to Promote Neuron SurvivalTami Kingsbury; Fiscal Year: 2008..to reduced levels of dopamine, PD patients also exhibit reduced levels of the brain- derived neurotrophic factor BDNF (Mogi et al., 1999)...
- Development of Basic Components of Decision MakingBETTY CASEY; Fiscal Year: 2008..The proposed studies are in response to RFA # DA-04-009 Behavioral and Cognitive Processes Related to Adolescent Drug Abuse. ..
- Chromatin Alterations in Rett SyndromeSchahram Akbarian; Fiscal Year: 2009..It is expected that these approaches will provide a clear and comprehensive picture on the developmental regulation of histone modifications in cortical neurons, including potential changes in MECP2-deficient brain. ..
- Treating Depression with Histone Deacetylase InhibitorsSchahram Akbarian; Fiscal Year: 2006..abstract_text> ..
- Functional neuroanatomical deficits in ADHD familiesBETTY CASEY; Fiscal Year: 2003..Imaging will be performed at corresponding imaging sites at DUMC, Weill Medical College of Cornell University, and Stanford University respectively. ..
- DISSECTING THE EAR NEUROSENSORY DEVELOPMENT.Bernd Fritzsch; Fiscal Year: 2010..will molecularly dissect the role of neurotrophins in neonatal and postnatal fiber reorganization using conditional Bdnf ear mutations in combination with transgenic misexpressors...
- REGULATION OF MASTICATORY MUSCLE FIBER PHENOTYPEARTHUR ENGLISH; Fiscal Year: 2002..The new knowledge generated will impact significantly several areas of clinical dentistry. ..
- Serotonin Receptor Subtypes: Regulation and InteractionJULIE HENSLER; Fiscal Year: 2008..Studies of the regulation of 5-HT1A receptor function may have important implications for our understanding the role of this receptor in the therapeutic action of drugs used to treat mental illness [unreadable] [unreadable]..
- Development of Prediction and Reward Related CircuitryBETTY CASEY; Fiscal Year: 2004..The proposed studies will lay the critical groundwork, both scientific and methodological, for subsequent studies on substance abuse in children. ..