Car1

Summary

Gene Symbol: Car1
Description: carbonic anhydrase 1
Alias: AW555628, Ca1, Car-1, carbonic anhydrase 1, CA-I, carbonate dehydratase I, carbonic anhydrase I
Species: mouse

Top Publications

  1. doi Regulatory dendritic cells pulsed with carbonic anhydrase I protect mice from colitis induced by CD4+CD25- T cells
    Hirofumi Yamanishi
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791 0295, Japan
    J Immunol 188:2164-72. 2012
  2. pmc Carbonic anhydrase enzymes regulate mast cell-mediated inflammation
    Everett K Henry
    Center for Immunity and Inflammation, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103 Department of Medicine, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103
    J Exp Med 213:1663-73. 2016
  3. doi Purification and Transcriptomic Analysis of Mouse Fetal Leydig Cells Reveals Candidate Genes for Specification of Gonadal Steroidogenic Cells
    Kathryn S McClelland
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia
    Biol Reprod 92:145. 2015
  4. ncbi The Coxsackievirus and adenovirus receptor (CAR) forms a complex with the PDZ domain-containing protein ligand-of-numb protein-X (LNX)
    Kerstin Sollerbrant
    Ludwig Institute for Cancer Research, Stockholm Branch, Karolinska Intitutet, SE 17177 Stockholm, Sweden
    J Biol Chem 278:7439-44. 2003
  5. pmc Transgenic mice over-expressing carbonic anhydrase I showed aggravated joint inflammation and tissue destruction
    Yabing Zheng
    Medical Research Center of Shandong Provincial Qianfoshan Hospital, Shandong University, Jingshi road 16766, Jinan, Shandong 250014, PR China
    BMC Musculoskelet Disord 13:256. 2012
  6. doi A systematic survey of carbonic anhydrase mRNA expression during mammalian inner ear development
    Ling Wu
    Department of Anatomy, Yonsei University College of Medicine, Seoul, South Korea
    Dev Dyn 242:269-80. 2013
  7. pmc Ldb1 regulates carbonic anhydrase 1 during erythroid differentiation
    Sang Hyun Song
    Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
    Biochim Biophys Acta 1819:885-91. 2012
  8. pmc Erythroid expression and DNAaseI-hypersensitive sites of the carbonic anhydrase 1 gene
    J Sowden
    MRC Human Biochemical Genetics Unit, Galton Laboratory UCL, London, U K
    Biochem J 288:545-51. 1992
  9. ncbi Esterase-16 (es-16): characterization, polymorphism, and linkage to chromosome 3 of a kidney esterase locus of the house mouse
    O H von Deimling
    Biochem Genet 19:1091-9. 1981
  10. ncbi Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene
    B Nuez
    MGC Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands
    Nature 375:316-8. 1995

Scientific Experts

  • K Sollerbrant
  • Sang Hyun Song
  • Bjarne Knudsen
  • Pei wen Pan
  • Everett K Henry
  • Kathryn S McClelland
  • Ling Wu
  • Hirofumi Yamanishi
  • Yabing Zheng
  • C Nguyen
  • Umashankar Singh
  • Daniel F Dwyer
  • Patricia Soteropoulos
  • Amariliz Rivera
  • Mark C Siracusa
  • Juan M Inclan-Rico
  • Saleena S Ghanny
  • Chandler B Sy
  • Vanessa Espinosa
  • Vincent R Harley
  • Peter Koopman
  • Andrew H Sinclair
  • Christian Larney
  • Katrina Bell
  • Alicia Oshlack
  • Josephine Bowles
  • Un Kyung Kim
  • Jinwoong Bok
  • Jae Young Choi
  • Borum Sagong
  • Bunzo Matsuura
  • Wei Zhang
  • Masanori Abe
  • Yoichi Hiasa
  • Lin Wang
  • Xiaotian Chang
  • Hidehiro Murakami
  • Morikazu Onji
  • Hengwei Xu
  • Teru Kumagi
  • Yoshiou Ikeda
  • E Singson
  • R Attia
  • S Cha
  • M Bulosan
  • J G Cornelius
  • A B Peck
  • M E Doyle
  • J Y Kim
  • Ulrike A Nuber
  • Wei Shi
  • Myriam C Hemberger
  • Rosemary W Elliott
  • Hiroshi Ohta
  • Aikaterini Varanou
  • Tong Sun
  • Teruhiko Wakayama
  • Reinald Fundele
  • Ralph Schulz
  • T Sudo
  • B Nuez
  • J Li
  • A Bygrave
  • N Goto
  • F Grosveld
  • D Michalovich
  • K Fukuta
  • H Mannen
  • R Ploemacher
  • S Tsuji
  • M Nishimura
  • J Sowden
  • S Y Chow
  • Y H Edwards
  • M Edwards
  • M T Davisson
  • P H Butterworth
  • E M Eicher
  • K Morrison
  • N Lowe
  • P J Fraser
  • P Fraser
  • O H von Deimling
  • C Beechey
  • P Curtis
  • S C Reynolds
  • J Peters
  • P J Curtis
  • P Cummings
  • Y Edwards

Detail Information

Publications22

  1. doi Regulatory dendritic cells pulsed with carbonic anhydrase I protect mice from colitis induced by CD4+CD25- T cells
    Hirofumi Yamanishi
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791 0295, Japan
    J Immunol 188:2164-72. 2012
    ..Using two-dimensional gel electrophoresis and MALDI-TOF mass spectrometry, carbonic anhydrase I (CA I) was identified as a major protein of CBA...
  2. pmc Carbonic anhydrase enzymes regulate mast cell-mediated inflammation
    Everett K Henry
    Center for Immunity and Inflammation, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103 Department of Medicine, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103
    J Exp Med 213:1663-73. 2016
    ..Further, we used CRISPR/Cas9 technology and illustrate that genetically editing Car1 is sufficient to selectively reduce mast cell development...
  3. doi Purification and Transcriptomic Analysis of Mouse Fetal Leydig Cells Reveals Candidate Genes for Specification of Gonadal Steroidogenic Cells
    Kathryn S McClelland
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia
    Biol Reprod 92:145. 2015
    ..In addition, it provides a basis for targeted studies designed to identify causes of idiopathic XY DSD. ..
  4. ncbi The Coxsackievirus and adenovirus receptor (CAR) forms a complex with the PDZ domain-containing protein ligand-of-numb protein-X (LNX)
    Kerstin Sollerbrant
    Ludwig Institute for Cancer Research, Stockholm Branch, Karolinska Intitutet, SE 17177 Stockholm, Sweden
    J Biol Chem 278:7439-44. 2003
    ..CAR and LNX were also shown to colocalize in vivo in mammalian cells. We speculate that CAR and LNX are part of a larger protein complex that might have important functions at discrete subcellular localizations in the cell...
  5. pmc Transgenic mice over-expressing carbonic anhydrase I showed aggravated joint inflammation and tissue destruction
    Yabing Zheng
    Medical Research Center of Shandong Provincial Qianfoshan Hospital, Shandong University, Jingshi road 16766, Jinan, Shandong 250014, PR China
    BMC Musculoskelet Disord 13:256. 2012
    Studies have demonstrated that carbonic anhydrase I (CA1) stimulates calcium salt precipitation and cell calcification, which is an essential step in new bone formation...
  6. doi A systematic survey of carbonic anhydrase mRNA expression during mammalian inner ear development
    Ling Wu
    Department of Anatomy, Yonsei University College of Medicine, Seoul, South Korea
    Dev Dyn 242:269-80. 2013
    ..To understand the specific roles of CA isozymes in the inner ear, a systematic survey was conducted to reveal temporal and spatial expression patterns of all 16 CA isozymes during inner ear development...
  7. pmc Ldb1 regulates carbonic anhydrase 1 during erythroid differentiation
    Sang Hyun Song
    Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
    Biochim Biophys Acta 1819:885-91. 2012
    b>Carbonic anhydrase 1 (Car1), an early specific marker of the erythroid differentiation, has been used to distinguish fetal and adult erythroid cells since its production closely follows the γ- to β-globin transition, but the molecular ..
  8. pmc Erythroid expression and DNAaseI-hypersensitive sites of the carbonic anhydrase 1 gene
    J Sowden
    MRC Human Biochemical Genetics Unit, Galton Laboratory UCL, London, U K
    Biochem J 288:545-51. 1992
    The carbonic anhydrase 1 gene is expressed in adult human and mouse erythroid cells and colon epithelia from two distinct promoters...
  9. ncbi Esterase-16 (es-16): characterization, polymorphism, and linkage to chromosome 3 of a kidney esterase locus of the house mouse
    O H von Deimling
    Biochem Genet 19:1091-9. 1981
    ..Es-16 is closely linked to Car-1 and Car-2 on chromosome 3 Typing of 94 animals of the backcross (C57BL/10Sn x M. m. mol.) F1 x M. m. mol. revealed a recombination frequency of 8.51 /+- 2.9%...
  10. ncbi Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene
    B Nuez
    MGC Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands
    Nature 375:316-8. 1995
    ..Enucleated erythrocytes are formed but these do not contain the proper amount of haemoglobin. We conclude that the transcription factor EKLF is essential for the final steps of definitive erythropoiesis in fetal liver...
  11. ncbi Subcellular distribution of carbonic anhydrase and Na+,K(+)-ATPase in the brain of the hyt/hyt hypothyroid mice
    J Li
    Department of Physiology, University of Utah School of Medicine, Salt Lake City 84108
    Neurochem Res 19:83-8. 1994
    ..abstract truncated at 250 words)..
  12. ncbi Genes on chromosome 3 of the mouse
    M T Davisson
    J Hered 67:155-6. 1976
    ..The Robertsonian translocation Rb(1.3) 1Bnr was used as a marker for the centromere of Chromosome 3. The loci map is as follows: centromere-2.5cM-(Car-1, Car-2)-26cM-my...
  13. pmc Using evolutionary rates to investigate protein functional divergence and conservation. A case study of the carbonic anhydrases
    Bjarne Knudsen
    Bioinformatics Research Center, University of Aarhus, 8000 Aarhus C, Denmark
    Genetics 164:1261-9. 2003
    ..As illustrated by the CAs, these LRTs, in combination with other biological evidence, offer a powerful and cost-effective approach for testing hypotheses, making predictions, and designing experiments in protein functional studies...
  14. ncbi Expression and functional analysis of genes deregulated in mouse placental overgrowth models: Car2 and Ncam1
    Umashankar Singh
    Department of Development and Genetics, Evolutionary Biology Center, Uppsala University, Sweden
    Dev Dyn 234:1034-45. 2005
    ..This strongly suggested that altered expression of Car2 and Ncam1 is a downstream event in placental hyperplasia...
  15. ncbi Sjögren's syndrome-like disease of C57BL/6.NOD-Aec1 Aec2 mice: gender differences in keratoconjunctivitis sicca defined by a cross-over in the chromosome 3 Aec1 locus
    C Nguyen
    Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA
    Scand J Immunol 64:295-307. 2006
    ..These data suggest SjS-like disease in the NOD mouse shows gender-specific regulation determined by autosomal genes...
  16. pmc A systematic quantification of carbonic anhydrase transcripts in the mouse digestive system
    Pei wen Pan
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, 33520, Tampere, Finland
    BMC Mol Biol 8:22. 2007
    ..In the present study, we systematically examined the mRNA expression levels of all known CA isozymes by quantitative real-time PCR in eight tissues of the digestive system of male and female mice...
  17. ncbi Molecular evolution of the carbonic anhydrase genes: calculation of divergence time for mouse carbonic anhydrase I and II
    P J Fraser
    J Mol Evol 23:294-9. 1986
    ..The divergence-time calculation provides the first estimation of the evolutionary relationship between CAs based entirely on nucleotide sequence comparison...
  18. pmc The mouse carbonic anhydrase I gene contains two tissue-specific promoters
    P Fraser
    Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104
    Mol Cell Biol 9:3308-13. 1989
    We report the isolation and characterization of the mouse carbonic anhydrase I (CAI) gene...
  19. ncbi Mapping of mouse carbonic anhydrase-3, Car-3: another locus in the homologous region of mouse chromosome 3 and human chromosome 8
    C Beechey
    MRC Radiobiology Unit, Chilton, Didcot, Oxon, United Kingdom
    Genomics 6:692-6. 1990
    ....
  20. ncbi Physical mapping of the human carbonic anhydrase gene cluster on chromosome 8
    N Lowe
    Department of Biochemistry, University College London, United Kingdom
    Genomics 10:882-8. 1991
    ..These genes have been mapped using pulsed-field gel electrophoresis. The genes lie in the order CA2, CA3, CA1. CA2 and CA3 are separated by 20 kb and are transcribed in the same direction, away from CA1...
  21. ncbi Evolution of mammalian carbonic anhydrase loci by tanden duplication: close linkage of Car-1 and Car-2 to the centromere region of chromosome 3 of the mouse
    E M Eicher
    Biochem Genet 14:651-60. 1976
    Electrophoretic variants of two carbonic anhydrase enzymes CAR-1 (CA I) and Car-2 (CA II), have been found in the laboratory mouse, Mus musculus...
  22. ncbi Identification and minisatellite linkage analysis of SMXA recombinant inbred strains of mice by DNA fingerprinting
    T Sudo
    Laboratory of Animal Breeding and Genetics, Faculty of Agriculture, Kobe University, Japan
    Exp Anim 44:87-93. 1995
    ..The results suggested that DNA fingerprinting with M13 phage DNA is applicable not only for strain identification but also for genetic monitoring of RI strains on almost all chromosomes...