Car4

Summary

Gene Symbol: Car4
Description: carbonic anhydrase 4
Alias: AW456718, Ca4, carbonic anhydrase 4, CA-IV, carbonate dehydratase IV, carbonic anhydrase IV
Species: mouse

Top Publications

  1. pmc Role of carbonic anhydrase IV in the bicarbonate-mediated activation of murine and human sperm
    Petra M Wandernoth
    Department of Anatomy and Cell Biology, Saarland University, Homburg, Saar, Germany
    PLoS ONE 5:e15061. 2010
  2. pmc The taste of carbonation
    Jayaram Chandrashekar
    Howard Hughes Medical Institute and Departments of Neurobiology and Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA
    Science 326:443-5. 2009
  3. pmc Carbonic anhydrase XIV deficiency produces a functional defect in the retinal light response
    Judith Mosinger Ogilvie
    Department of Biology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Proc Natl Acad Sci U S A 104:8514-9. 2007
  4. ncbi Carbonic anhydrase in mouse testis and epididymis; transfer of isozyme IV to spermatozoa during passage
    Elisabeth Ekstedt
    Department of Anatomy and Physiology, Centre for Reproductive Biology in Uppsala, Swedish University of Agricultural Sciences, S 75007 Uppsala, Sweden
    J Mol Histol 35:167-73. 2004
  5. pmc Characterization of CA XV, a new GPI-anchored form of carbonic anhydrase
    Mika Hilvo
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, Biokatu 6, 33520 Tampere, Finland
    Biochem J 392:83-92. 2005
  6. pmc Carbonic anhydrase IV and XIV knockout mice: roles of the respective carbonic anhydrases in buffering the extracellular space in brain
    Gul N Shah
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Proc Natl Acad Sci U S A 102:16771-6. 2005
  7. pmc Expression of membrane-bound carbonic anhydrases IV, IX, and XIV in the mouse heart
    Renate J Scheibe
    Zentrum Physiologie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    J Histochem Cytochem 54:1379-91. 2006
  8. ncbi Carbonic anhydrases IV and IX: subcellular localization and functional role in mouse skeletal muscle
    Renate J Scheibe
    Zentrum Biochemie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    Am J Physiol Cell Physiol 294:C402-12. 2008
  9. doi Bcl11b/Ctip2 is required for development of lingual papillae in mice
    Yugo Nishiguchi
    Department of Bioengineering, Graduate School of Bioscience and Bioengineering, Tokyo Institute of Technology, Yokohama 226 8501, Japan
    Dev Biol 416:98-110. 2016
  10. pmc Normal Fertility Requires the Expression of Carbonic Anhydrases II and IV in Sperm
    Petra M Wandernoth
    From the Institute of Anatomy, University Hospital, University Duisburg Essen, Hufelandstrase 55, 45122 Essen, Germany
    J Biol Chem 290:29202-16. 2015

Scientific Experts

  • Pei wen Pan
  • M Hilvo
  • Diana Borenshtein
  • William S Sly
  • Abdul Waheed
  • Gul N Shah
  • Petra M Wandernoth
  • Renate J Scheibe
  • Holger M Becker
  • Seppo Parkkila
  • Janine Hallerdei
  • Petra Wetzel
  • Gerolf Gros
  • Nataliya Svichar
  • Yugo Nishiguchi
  • Milica Vujovic
  • Collin J Kreple
  • Claes Göran Reibring
  • Ting Wen
  • Hans Peter Schneider
  • Ling Wu
  • Gunther Wennemuth
  • Nadja Mannowetz
  • Joachim W Deitmer
  • Xia Wang
  • Woong Kim
  • J D Hurt
  • Jean Giacomotto
  • Jayaram Chandrashekar
  • Hiromichi Narumiya
  • Mitchell Chesler
  • Judith Mosinger Ogilvie
  • Barbara Ulmasov
  • Jeffrey H Grubb
  • Elisabeth Ekstedt
  • Douglas A Whittington
  • Ichiro Matsumoto
  • Bernardo V Alvarez
  • Makoto Ohmoto
  • Takayuki Enomoto
  • Ryo Kominami
  • Jun Koki
  • Junji Hirota
  • Joanna Hård
  • Anne Wolf
  • Laura Grannemann
  • Peter Solsjö
  • Susi Dudazy-Gralla
  • Amy Warner
  • Jaroslaw Szczyrba
  • Bjorn Vennstrom
  • Jens Mittag
  • Rong Fan
  • M Eyad Khorki
  • Maha El Shahawy
  • Marc E Rothenberg
  • Marie Kannius-Janson
  • Yimo Wang
  • Ali Ghobbeh
  • Madeliene Stump
  • Jason J Radley
  • John A Wemmie
  • Anders Linde
  • Jianyang Du
  • Ryan T Lalumiere
  • Yuan Lu
  • Rebecca J Taugher
  • Oliver Pabst
  • Nives Zimmermann
  • Levi P Sowers
  • Michael J Welsh
  • Kristina Hallberg
  • Benjamin Wahl
  • Amel Gritli-Linde
  • Caitlin V Cosme
  • S Tamai
  • Melissa K Mingler
  • Jeanette Nilsson
  • Andrea L Schwager-Gutman
  • Alena Spiess
  • Jae Young Choi
  • Michael Klier
  • Jinwoong Bok
  • Un Kyung Kim
  • W S Sly
  • Fabian T Andes
  • Marco D Alt
  • Borum Sagong
  • L P Brion
  • D A Whittington

Detail Information

Publications35

  1. pmc Role of carbonic anhydrase IV in the bicarbonate-mediated activation of murine and human sperm
    Petra M Wandernoth
    Department of Anatomy and Cell Biology, Saarland University, Homburg, Saar, Germany
    PLoS ONE 5:e15061. 2010
    ..We here show that murine sperm possess extracellular CA IV that is transferred to the sperm surface as the sperm pass through the epididymis...
  2. pmc The taste of carbonation
    Jayaram Chandrashekar
    Howard Hughes Medical Institute and Departments of Neurobiology and Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA
    Science 326:443-5. 2009
    ..we demonstrated that the sour-sensing cells act as the taste sensors for carbonation, and showed that carbonic anhydrase 4, a glycosylphosphatidylinositol-anchored enzyme, functions as the principal CO2 taste sensor...
  3. pmc Carbonic anhydrase XIV deficiency produces a functional defect in the retinal light response
    Judith Mosinger Ogilvie
    Department of Biology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Proc Natl Acad Sci U S A 104:8514-9. 2007
    ..b>CA IV and CA XIV are membrane-bound isozymes expressed in the eye...
  4. ncbi Carbonic anhydrase in mouse testis and epididymis; transfer of isozyme IV to spermatozoa during passage
    Elisabeth Ekstedt
    Department of Anatomy and Physiology, Centre for Reproductive Biology in Uppsala, Swedish University of Agricultural Sciences, S 75007 Uppsala, Sweden
    J Mol Histol 35:167-73. 2004
    ..Spermatozoa, when studied in both the scanning electron and light microscope, were found to pickup membrane-bound CA IV during their passage through the epididymal duct...
  5. pmc Characterization of CA XV, a new GPI-anchored form of carbonic anhydrase
    Mika Hilvo
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, Biokatu 6, 33520 Tampere, Finland
    Biochem J 392:83-92. 2005
    ..Phylogenetic analysis showed that mouse CA XV is related to CA IV. Therefore both of these enzymes were expressed in COS-7 cells and studied in parallel experiments...
  6. pmc Carbonic anhydrase IV and XIV knockout mice: roles of the respective carbonic anhydrases in buffering the extracellular space in brain
    Gul N Shah
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Proc Natl Acad Sci U S A 102:16771-6. 2005
    ..of these two isozymes in this and other physiological functions attributed to extracellular CAs, we produced CA IV and CA XIV knockout (KO) mice by targeted mutagenesis and the doubly deficient CA IV/XIV KO mice by intercrossing ..
  7. pmc Expression of membrane-bound carbonic anhydrases IV, IX, and XIV in the mouse heart
    Renate J Scheibe
    Zentrum Physiologie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    J Histochem Cytochem 54:1379-91. 2006
    Expression of membrane-bound carbonic anhydrases (CAs) of CA IV, CA IX, CA XII, and CA XIV has been investigated in the mouse heart...
  8. ncbi Carbonic anhydrases IV and IX: subcellular localization and functional role in mouse skeletal muscle
    Renate J Scheibe
    Zentrum Biochemie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    Am J Physiol Cell Physiol 294:C402-12. 2008
    ..b>CA IV has been found to be located on the plasma membrane as well as on the sarcoplasmic reticulum (SR) membrane...
  9. doi Bcl11b/Ctip2 is required for development of lingual papillae in mice
    Yugo Nishiguchi
    Department of Bioengineering, Graduate School of Bioscience and Bioengineering, Tokyo Institute of Technology, Yokohama 226 8501, Japan
    Dev Biol 416:98-110. 2016
    ..These results indicate that Bcl11b regulates the differentiation of keratinocytes in the tongue and identify Bcl11b as an essential factor for the lingual papilla morphogenesis. ..
  10. pmc Normal Fertility Requires the Expression of Carbonic Anhydrases II and IV in Sperm
    Petra M Wandernoth
    From the Institute of Anatomy, University Hospital, University Duisburg Essen, Hufelandstrase 55, 45122 Essen, Germany
    J Biol Chem 290:29202-16. 2015
    ..These results suggest that CAII and CAIV are required for optimal fertilization. ..
  11. doi Thyroid hormone drives the expression of mouse carbonic anhydrase Car4 in kidney, lung and brain
    Milica Vujovic
    Karolinska Institutet, Department of Cell and Molecular Biology, 17177 Stockholm, Sweden
    Mol Cell Endocrinol 416:19-26. 2015
    ..model with a mutation in thyroid hormone receptor α1 (TRα1), we here demonstrate that the expression of carbonic anhydrase 4 in lung and brain of the adult animal depends on intact TRα1 signaling...
  12. pmc Acid-sensing ion channels contribute to synaptic transmission and inhibit cocaine-evoked plasticity
    Collin J Kreple
    1 Medical Scientist Training Program, University of Iowa, Iowa City, Iowa, USA 2 Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa, USA 3
    Nat Neurosci 17:1083-91. 2014
    ..Together, these data suggest that ASIC1A inhibits the plasticity underlying addiction-related behavior and raise the possibility of developing therapies for drug addiction by targeting ASIC-dependent neurotransmission. ..
  13. pmc Carbonic anhydrase IV is expressed on IL-5-activated murine eosinophils
    Ting Wen
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 and
    J Immunol 192:5481-9. 2014
    ..b>Carbonic anhydrase IV (Car4) was a top dysregulated gene with 36-fold induction in allergen-elicited pulmonary eosinophils, ..
  14. pmc Expression patterns and subcellular localization of carbonic anhydrases are developmentally regulated during tooth formation
    Claes Göran Reibring
    Department of Oral Biochemistry, Sahlgrenska Academy at the University of Gothenburg, Goteborg, Sweden
    PLoS ONE 9:e96007. 2014
    ..Our study provides important information for future single or multiple gene targeting strategies aiming at deciphering the function of CAs during odontogenesis. ..
  15. ncbi Expression, assay, and structure of the extracellular domain of murine carbonic anhydrase XIV: implications for selective inhibition of membrane-associated isozymes
    Douglas A Whittington
    Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 279:7223-8. 2004
    ..The amino acid sequence identity of human CA XIV relative to the other membrane-associated isozymes (CA IV, CA IX, and CA XII) is 34-46%...
  16. pmc GPI-anchored carbonic anhydrase IV displays both intra- and extracellular activity in cRNA-injected oocytes and in mouse neurons
    Hans Peter Schneider
    Abteilung fur Allgemeine Zoologie, Fachbereich Biologie, University of Kaiserslautern, D 67653 Kaiserslautern, Germany
    Proc Natl Acad Sci U S A 110:1494-9. 2013
    ..b>CA IV expression in oocytes was confirmed by immunocytochemistry, and CA IV activity measured by mass spectrometry...
  17. doi A systematic survey of carbonic anhydrase mRNA expression during mammalian inner ear development
    Ling Wu
    Department of Anatomy, Yonsei University College of Medicine, Seoul, South Korea
    Dev Dyn 242:269-80. 2013
    ..To understand the specific roles of CA isozymes in the inner ear, a systematic survey was conducted to reveal temporal and spatial expression patterns of all 16 CA isozymes during inner ear development...
  18. pmc The period of the somite segmentation clock is sensitive to Notch activity
    Woong Kim
    Laboratory of Gene Regulation Research, Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara 630 0192, Japan
    Mol Biol Cell 22:3541-9. 2011
    ..Therefore we propose that the period of the somite segmentation clock is sensitive to Notch activity and that Nrarp plays essential roles in the morphology of vertebrae and ribs...
  19. pmc T tubules and surface membranes provide equally effective pathways of carbonic anhydrase-facilitated lactic acid transport in skeletal muscle
    Janine Hallerdei
    Molecular and Cell Physiology, Vegetative Physiologie, Medizinische Hochschule Hannover, Hannover, Germany
    PLoS ONE 5:e15137. 2010
    ..The data suggest that about half the CA-dependent muscular lactate flux occurs across the surface membrane, while the other half occurs across the membranes of the T tubuli...
  20. ncbi Up-regulation of carbonic anhydrase isozyme IV in CNS myelin of mice genetically deficient in carbonic anhydrase II
    L P Brion
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461
    J Neurochem 63:360-6. 1994
    ..CA(II)D resulted in a much lower total CA specific activity in all tissues examined but in higher CA IV specific activities in soluble and membrane-associated fractions and pure myelin...
  21. ncbi Molecular cloning of the mouse gene coding for carbonic anhydrase IV
    S Tamai
    E A Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, Missouri 63104, USA
    Biochem Genet 34:31-43. 1996
    b>Carbonic anhydrase IV (CA IV) is expressed on apical surfaces of renal tubular epithelium and endothelium of specialized capillary beds. It plays a key role in bicarbonate reabsorption in kidney and in CO2 transport in other tissues...
  22. pmc Gly-63-->Gln substitution adjacent to His-64 in rodent carbonic anhydrase IVs largely explains their reduced activity
    S Tamai
    Edward A Doisy Department of Biochemistry and Molecular Biology, St Louis University Health Sciences Center, MO 63104, USA
    Proc Natl Acad Sci U S A 93:13647-52. 1996
    ..CA IVs purified from bovine and rabbit lungs are high-activity enzymes, like human CA IV, while CA IV from mouse and rat lungs had only 10-20% as much catalytic activity...
  23. ncbi Catalytic properties of murine carbonic anhydrase IV
    J D Hurt
    Department of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, Florida 32610 0267, USA
    J Biol Chem 272:13512-8. 1997
    A cDNA encoding the murine carbonic anhydrase IV (mCA IV) gene, modified to resemble a form of mature human carbonic anhydrase IV (Okuyama, T., Waheed, A., Kusumoto, W., Zhu, X. L., and Sly, W. S. (1995) Arch. Biochem. Biophys...
  24. ncbi Expression of carbonic anhydrase IV in carbonic anhydrase II-deficient mice
    L P Brion
    Albert Einstein College of Medicine, Department of Pediatrics, Medicine, Bronx, New York 10461, USA
    Am J Physiol 273:F234-45. 1997
    ..This study was designed to assess CA IV expression in a model of CMA in the mouse, i.e., congenital deficiency in CA II [CA(II)D]...
  25. ncbi Isolation and expression of murine carbonic anhydrase IV
    J D Hurt
    Department of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    Protein Expr Purif 12:7-16. 1998
    A 1193-bp cDNA containing the complete murine carbonic anhydrase IV coding sequence was isolated from a Balb/c kidney cDNA library...
  26. pmc Residual embryonic cells as precursors of a Barrett's-like metaplasia
    Xia Wang
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 145:1023-35. 2011
    ..Our findings suggest that certain precancerous lesions, such as Barrett's, initiate not from genetic alterations but from competitive interactions between cell lineages driven by opportunity...
  27. pmc A systematic quantification of carbonic anhydrase transcripts in the mouse digestive system
    Pei wen Pan
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, 33520, Tampere, Finland
    BMC Mol Biol 8:22. 2007
    ..In the present study, we systematically examined the mRNA expression levels of all known CA isozymes by quantitative real-time PCR in eight tissues of the digestive system of male and female mice...
  28. pmc Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: molecular basis of isozyme-drug discrimination
    T Stams
    Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia 19104 6323, USA
    Protein Sci 7:556-63. 1998
    b>Carbonic anhydrase IV (CAIV) is a membrane-associated enzyme anchored to plasma membrane surfaces by a phosphatidylinositol glycan linkage. We have determined the 2...
  29. doi Carbonic anhydrases in the mouse harderian gland
    Pei wen Pan
    Institute of Medical Technology, University of Tampere, Biokatu 6, 33520 Tampere, Finland
    J Mol Histol 41:411-7. 2010
    ..Nine CA mRNAs were detectable in the gland. Car5b and Car13 showed the highest signals. Car4, Car6, and Car12 showed moderate expression levels, whereas Car2, Car3, Car7, and Car15 mRNAs were barely within ..
  30. doi Evaluation of the therapeutic potential of carbonic anhydrase inhibitors in two animal models of dystrophin deficient muscular dystrophy
    Jean Giacomotto
    Centre de Genetique Moleculaire et Cellulaire, UMR 5534, Universite Lyon 1, 69622 Villeurbanne Cedex, France
    Hum Mol Genet 18:4089-101. 2009
    ..These studies further demonstrated that a C. elegans-based screen coupled with a mouse model validation strategy can lead to the identification of potential pharmacological agents for rare diseases...
  31. pmc Decreased expression of colonic Slc26a3 and carbonic anhydrase iv as a cause of fatal infectious diarrhea in mice
    Diana Borenshtein
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Infect Immun 77:3639-50. 2009
    ..and FVB/N was associated with significant fluid loss in feces, a remarkable downregulation of Slc26a3 and carbonic anhydrase IV (CAIV) message and protein expression, retention of chloride in stool, and hypochloremia, suggesting ..
  32. pmc Carbonic anhydrases CA4 and CA14 both enhance AE3-mediated Cl--HCO3- exchange in hippocampal neurons
    Nataliya Svichar
    Department of Neurosurgery, New York University Langone Medical Center, New York, New York 10016, USA
    J Neurosci 29:3252-8. 2009
    Carbonic anhydrase (CA) activity in the brain extracellular space is attributable mainly to isoforms CA4 and CA14...
  33. ncbi Direct extracellular interaction between carbonic anhydrase IV and the human NBC1 sodium/bicarbonate co-transporter
    Bernardo V Alvarez
    Department of Physiology, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
    Biochemistry 42:12321-9. 2003
    ..Electrogenic NBC1 catalyzes HCO(3)(-) fluxes in mammalian kidney, pancreas, and heart cells. Carbonic anhydrase IV (CAIV), which is also present in these tissues, is glycosylphosphatidyl inositol-anchored to the outer ..
  34. ncbi Endocardiogenesis in embryoid bodies: novel markers identified by gene expression profiling
    Hiromichi Narumiya
    Department of Bioscience, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Biochem Biophys Res Commun 357:896-902. 2007
    ..Further, they indicate that these new marker genes are useful to study the origin and induction of endocardial cells, and identify other endocardial markers...
  35. pmc Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells
    D A Whittington
    Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104 6323, USA
    Proc Natl Acad Sci U S A 98:9545-50. 2001
    ..The structure of the CA XII-acetazolamide complex is also reported at 1.50-A resolution, and prospects for the design of CA XII-specific inhibitors of possible chemotherapeutic value are discussed...