Car5b

Summary

Gene Symbol: Car5b
Description: carbonic anhydrase 5b, mitochondrial
Alias: 7330410H16Rik, CAVB, Ca5b, CarVb, D730005F19Rik, carbonic anhydrase 5B, mitochondrial, CA-VB, carbonate dehydratase VB, carbonic anhydrase VB
Species: mouse

Top Publications

  1. pmc Mitochondrial carbonic anhydrase CA VB: differences in tissue distribution and pattern of evolution from those of CA VA suggest distinct physiological roles
    G N Shah
    Edward A Doisy Department of Biochemistry and Molecular Biology, Department of Pediatrics, St Louis University School of Medicine, St Louis, MO 63104, USA
    Proc Natl Acad Sci U S A 97:1677-82. 2000
  2. pmc Topiramate treatment protects blood-brain barrier pericytes from hyperglycemia-induced oxidative damage in diabetic mice
    Tulin O Price
    Division of Endocrinology, Department of Internal Medicine, Saint Louis University, Edward A Doisy Research Center, 1100 South Grand Boulevard, St Louis, Missouri 63104, USA
    Endocrinology 153:362-72. 2012
  3. doi A systematic survey of carbonic anhydrase mRNA expression during mammalian inner ear development
    Ling Wu
    Department of Anatomy, Yonsei University College of Medicine, Seoul, South Korea
    Dev Dyn 242:269-80. 2013
  4. pmc Targeted mutagenesis of mitochondrial carbonic anhydrases VA and VB implicates both enzymes in ammonia detoxification and glucose metabolism
    Gul N Shah
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Proc Natl Acad Sci U S A 110:7423-8. 2013
  5. pmc A systematic quantification of carbonic anhydrase transcripts in the mouse digestive system
    Pei wen Pan
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, 33520, Tampere, Finland
    BMC Mol Biol 8:22. 2007
  6. doi Carbonic anhydrases in the mouse harderian gland
    Pei wen Pan
    Institute of Medical Technology, University of Tampere, Biokatu 6, 33520 Tampere, Finland
    J Mol Histol 41:411-7. 2010

Scientific Experts

  • Pei wen Pan
  • Gul N Shah
  • Ling Wu
  • Tulin O Price
  • Un Kyung Kim
  • Abdul Waheed
  • James D Shoemaker
  • William S Sly
  • Borum Sagong
  • Timothy S Rubbelke
  • Hien Nguyen
  • Joshua Hendin
  • Jinwoong Bok
  • Jae Young Choi
  • Nuran Ercal
  • Vijay Eranki
  • William A Banks
  • G N Shah
  • R E Fleming
  • W S Sly
  • M C Migas
  • A Waheed
  • D Hewett-Emmett
  • J H Grubb

Detail Information

Publications6

  1. pmc Mitochondrial carbonic anhydrase CA VB: differences in tissue distribution and pattern of evolution from those of CA VA suggest distinct physiological roles
    G N Shah
    Edward A Doisy Department of Biochemistry and Molecular Biology, Department of Pediatrics, St Louis University School of Medicine, St Louis, MO 63104, USA
    Proc Natl Acad Sci U S A 97:1677-82. 2000
    A cDNA for a second mouse mitochondrial carbonic anhydrase (CA) called CA VB was identified by homology to the previously characterized murine CA V, now called CA VA...
  2. pmc Topiramate treatment protects blood-brain barrier pericytes from hyperglycemia-induced oxidative damage in diabetic mice
    Tulin O Price
    Division of Endocrinology, Department of Internal Medicine, Saint Louis University, Edward A Doisy Research Center, 1100 South Grand Boulevard, St Louis, Missouri 63104, USA
    Endocrinology 153:362-72. 2012
    ..Thus, mitochondrial CA may provide a new therapeutic target for oxidative stress related illnesses of the central nervous system...
  3. doi A systematic survey of carbonic anhydrase mRNA expression during mammalian inner ear development
    Ling Wu
    Department of Anatomy, Yonsei University College of Medicine, Seoul, South Korea
    Dev Dyn 242:269-80. 2013
    ..To understand the specific roles of CA isozymes in the inner ear, a systematic survey was conducted to reveal temporal and spatial expression patterns of all 16 CA isozymes during inner ear development...
  4. pmc Targeted mutagenesis of mitochondrial carbonic anhydrases VA and VB implicates both enzymes in ammonia detoxification and glucose metabolism
    Gul N Shah
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Proc Natl Acad Sci U S A 110:7423-8. 2013
    ..of each enzyme, we studied the effects of targeted disruption of the murine CA genes, called Car5A and Car5B. The Car5A mutation had several deleterious consequences...
  5. pmc A systematic quantification of carbonic anhydrase transcripts in the mouse digestive system
    Pei wen Pan
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, 33520, Tampere, Finland
    BMC Mol Biol 8:22. 2007
    ..In the present study, we systematically examined the mRNA expression levels of all known CA isozymes by quantitative real-time PCR in eight tissues of the digestive system of male and female mice...
  6. doi Carbonic anhydrases in the mouse harderian gland
    Pei wen Pan
    Institute of Medical Technology, University of Tampere, Biokatu 6, 33520 Tampere, Finland
    J Mol Histol 41:411-7. 2010
    ..Nine CA mRNAs were detectable in the gland. Car5b and Car13 showed the highest signals...