Car9

Summary

Gene Symbol: Car9
Description: carbonic anhydrase 9
Alias: CAIX, Ca9, MN/CA9, carbonic anhydrase 9, CA-IX, carbonate dehydratase IX, carbonic anhydrase IX, membrane antigen MN homolog
Species: mouse

Top Publications

  1. ncbi Expression of carbonic anhydrase IX in mouse tissues
    Mika Hilvo
    Institute of Medical Technology, University of Tampere, Biokatu 6, 33520 Tampere, Finland
    J Histochem Cytochem 52:1313-22. 2004
  2. pmc Carbonic anhydrase isozyme-II-deficient mice lack the duodenal bicarbonate secretory response to prostaglandin E2
    Mari Leppilampi
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, FI 33520 Tampere, Finland
    Proc Natl Acad Sci U S A 102:15247-52. 2005
  3. pmc Expression of membrane-bound carbonic anhydrases IV, IX, and XIV in the mouse heart
    Renate J Scheibe
    Zentrum Physiologie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    J Histochem Cytochem 54:1379-91. 2006
  4. pmc Carbonic anhydrase IX has chaperone-like functions and is an immunoadjuvant
    Yanping Wang
    Department of Urologic Oncology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Mol Cancer Ther 7:3867-77. 2008
  5. ncbi Gastric hyperplasia in mice with targeted disruption of the carbonic anhydrase gene Car9
    Marta Ortova Gut
    Department of Molecular Genetics, Institute of Molecular Pharmacology and Medical Center of Free University of Berlin, Germany
    Gastroenterology 123:1889-903. 2002
  6. doi Brain phenotype of carbonic anhydrase IX-deficient mice
    Pei wen Pan
    Institute of Medical Technology, University of Tampere, Biokatu 6, 33520, Tampere, Finland
    Transgenic Res 21:163-76. 2012
  7. ncbi Gastric pit cell hyperplasia and glandular atrophy in carbonic anhydrase IX knockout mice: studies on two strains C57/BL6 and BALB/C
    Mari Leppilampi
    Department of Clinical Chemistry, University of Oulu, P O Box 5000, FIN 90014 Oulu, Finland
    Transgenic Res 14:655-63. 2005
  8. pmc Carbonic anhydrase gene expression in CA II-deficient (Car2-/-) and CA IX-deficient (Car9-/-) mice
    Peiwen Pan
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, Biokatu 6, 33520 Tampere, Finland
    J Physiol 571:319-27. 2006
  9. ncbi Carbonic anhydrases IV and IX: subcellular localization and functional role in mouse skeletal muscle
    Renate J Scheibe
    Zentrum Biochemie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    Am J Physiol Cell Physiol 294:C402-12. 2008
  10. pmc In Vivo Loss of Function Screening Reveals Carbonic Anhydrase IX as a Key Modulator of Tumor Initiating Potential in Primary Pancreatic Tumors
    Nabendu Pore
    MedImmune, LLC, Gaithersburg, MD, USA Electronic address
    Neoplasia 17:473-80. 2015

Scientific Experts

  • Patrick J Pollard
  • Morten Busk
  • Pei wen Pan
  • Heini Kallio
  • Mari Leppilampi
  • Seppo Parkkila
  • Abdul Waheed
  • Renate J Scheibe
  • William S Sly
  • Janine Hallerdei
  • Petra Wetzel
  • Gerolf Gros
  • Shawn C Chafe
  • Nabendu Pore
  • Sara Cioffi
  • Claes Göran Reibring
  • Toshifumi Maruyama
  • Ling Wu
  • Na Zhang
  • Silvia Pastorekova
  • Jaromir Pastorek
  • Twan van den Beucken
  • Marta Ortova Gut
  • Yanping Wang
  • Gul N Shah
  • Mika Hilvo
  • Monika Rafajová
  • Miriam Zat'ovicová
  • Robert Hollingsworth
  • Claudio Sorio
  • Andreas Möller
  • Shoukat Dedhar
  • Marylou Vallejo
  • Yuanmei Lou
  • Zheng Liu
  • Kevin L Bennewith
  • Adriana Gibadulinova
  • Aldo Scarpa
  • Melisa J Hamilton
  • Ivan Horak
  • Jaclyn Sceneay
  • Brandon Higgs
  • David A Tice
  • Emil Michelotti
  • Paul C McDonald
  • Sanjoo Jalla
  • Marie Kannius-Janson
  • Rosa Ferrentino
  • Stefania Martucciello
  • Anders Linde
  • Filomena Gabriella Fulcoli
  • Jeanette Nilsson
  • Elizabeth Illingworth
  • Maha El Shahawy
  • Marchesa Bilio
  • Kristina Hallberg
  • Edoardo Nusco
  • Amel Gritli-Linde
  • Kazuyoshi Baba
  • Kentaro Yoshimura
  • Jae Young Choi
  • Marie Hoshino
  • Tetsuhiko Tachikawa
  • Borum Sagong
  • Yoichi Miyamoto
  • Fuminori Iwasa
  • Masamichi Takami
  • Tetsuo Suzawa
  • Jinwoong Bok
  • Atsushi Yamada
  • Un Kyung Kim
  • Gou Yamamoto
  • Tomohito Akiyama
  • Kenji Mishima
  • Ryutaro Kamijo
  • Noriharu Ikumi
  • Volker Endeward
  • Sarah Linke
  • Daniel J Peet
  • Johana Chicher
  • Gabriel G Haddad
  • Randall S Johnson
  • Zhenxing Fu
  • DeeAnn Visk
  • Lorenz Poellinger
  • Frank Powell
  • Jeffrey J Gorman
  • Juraj Kopacek
  • Sylvia Pastorekova
  • Hilda Mujcic

Detail Information

Publications24

  1. ncbi Expression of carbonic anhydrase IX in mouse tissues
    Mika Hilvo
    Institute of Medical Technology, University of Tampere, Biokatu 6, 33520 Tampere, Finland
    J Histochem Cytochem 52:1313-22. 2004
    b>Carbonic anhydrase IX (CA IX) is a unique member of the CA gene family. In contrast to the other isozymes, it has been implicated in regulation of cell proliferation, adhesion, and malignant cell invasion...
  2. pmc Carbonic anhydrase isozyme-II-deficient mice lack the duodenal bicarbonate secretory response to prostaglandin E2
    Mari Leppilampi
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, FI 33520 Tampere, Finland
    Proc Natl Acad Sci U S A 102:15247-52. 2005
    ..0001. The DBS response to PGE2 was completely absent in Car2-/- mice, whereas basal DBS was normal. The CA IX-deficient mice with normal Car2 alleles showed a slight increase in DBS...
  3. pmc Expression of membrane-bound carbonic anhydrases IV, IX, and XIV in the mouse heart
    Renate J Scheibe
    Zentrum Physiologie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    J Histochem Cytochem 54:1379-91. 2006
    Expression of membrane-bound carbonic anhydrases (CAs) of CA IV, CA IX, CA XII, and CA XIV has been investigated in the mouse heart...
  4. pmc Carbonic anhydrase IX has chaperone-like functions and is an immunoadjuvant
    Yanping Wang
    Department of Urologic Oncology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Mol Cancer Ther 7:3867-77. 2008
    b>Carbonic anhydrase IX (CA9) is a hypoxia-regulated, transmembrane protein associated with neoplastic growth in a large spectrum of human tumors...
  5. ncbi Gastric hyperplasia in mice with targeted disruption of the carbonic anhydrase gene Car9
    Marta Ortova Gut
    Department of Molecular Genetics, Institute of Molecular Pharmacology and Medical Center of Free University of Berlin, Germany
    Gastroenterology 123:1889-903. 2002
    ..It is normally present in basolateral membranes of gastrointestinal epithelial cells and ectopically expressed in various carcinomas. To show its physiologic relevance, we have cloned the Car9 gene and generated CA IX-deficient mice.
  6. doi Brain phenotype of carbonic anhydrase IX-deficient mice
    Pei wen Pan
    Institute of Medical Technology, University of Tampere, Biokatu 6, 33520, Tampere, Finland
    Transgenic Res 21:163-76. 2012
    ..5-year-old carbonic anhydrase IX (CA IX)-deficient (Car9 (-/-)) mice...
  7. ncbi Gastric pit cell hyperplasia and glandular atrophy in carbonic anhydrase IX knockout mice: studies on two strains C57/BL6 and BALB/C
    Mari Leppilampi
    Department of Clinical Chemistry, University of Oulu, P O Box 5000, FIN 90014 Oulu, Finland
    Transgenic Res 14:655-63. 2005
    ..in gastric morphogenesis, since a recent study has shown gastric pit cell hyperplasia and glandular atrophy in CA IX-knockout mice...
  8. pmc Carbonic anhydrase gene expression in CA II-deficient (Car2-/-) and CA IX-deficient (Car9-/-) mice
    Peiwen Pan
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, Biokatu 6, 33520 Tampere, Finland
    J Physiol 571:319-27. 2006
    ..IV, IX, XII, XIII and XIV in the brain, kidney, stomach and colon of the wild-type, CA II-deficient (Car2-/-), and CA IX deficient (Car9-/-) mice...
  9. ncbi Carbonic anhydrases IV and IX: subcellular localization and functional role in mouse skeletal muscle
    Renate J Scheibe
    Zentrum Biochemie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    Am J Physiol Cell Physiol 294:C402-12. 2008
    The subcellular localization of carbonic anhydrase (CA) IV and CA IX in mouse skeletal muscle fibers has been studied immunohistochemically by confocal laser scanning microscopy...
  10. pmc In Vivo Loss of Function Screening Reveals Carbonic Anhydrase IX as a Key Modulator of Tumor Initiating Potential in Primary Pancreatic Tumors
    Nabendu Pore
    MedImmune, LLC, Gaithersburg, MD, USA Electronic address
    Neoplasia 17:473-80. 2015
    ..Several targets including carbonic anhydrase IX (CAIX), monocarboxylate transporter 4, and anionic amino acid transporter light chain, xc- system (xCT) ..
  11. doi Carbonic anhydrase IX promotes myeloid-derived suppressor cell mobilization and establishment of a metastatic niche by stimulating G-CSF production
    Shawn C Chafe
    Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada
    Cancer Res 75:996-1008. 2015
    ..b>Carbonic anhydrase IX (CAIX, CA9) expression is highly upregulated in hypoxic breast cancer cells through the action of hypoxia-..
  12. pmc Expression patterns and subcellular localization of carbonic anhydrases are developmentally regulated during tooth formation
    Claes Göran Reibring
    Department of Oral Biochemistry, Sahlgrenska Academy at the University of Gothenburg, Goteborg, Sweden
    PLoS ONE 9:e96007. 2014
    ..All CAs studied were produced by MA, however CAIV, CAIX and CARPXI proteins were distinctly enriched in the ruffled membrane of the ruffled MA but exhibited a homogeneous ..
  13. doi Tbx1 regulates brain vascularization
    Sara Cioffi
    Institute of Genetics and Biophysics ABT
    Hum Mol Genet 23:78-89. 2014
    ..2DS patients and to evaluate whether some of the anatomical and functional brain anomalies in patients may have a microvascular origin. ..
  14. pmc Downregulation of carbonic anhydrase IX promotes Col10a1 expression in chondrocytes
    Toshifumi Maruyama
    Department of Biochemistry, School of Dentistry, Showa University, Shinagawa, Tokyo, Japan
    PLoS ONE 8:e56984. 2013
    ..While it is known that CA IX is distributed in human embryonic chondrocytes, its role in chondrocyte differentiation has not been reported...
  15. doi A systematic survey of carbonic anhydrase mRNA expression during mammalian inner ear development
    Ling Wu
    Department of Anatomy, Yonsei University College of Medicine, Seoul, South Korea
    Dev Dyn 242:269-80. 2013
    ..To understand the specific roles of CA isozymes in the inner ear, a systematic survey was conducted to reveal temporal and spatial expression patterns of all 16 CA isozymes during inner ear development...
  16. pmc Hypoxia-induced expression of carbonic anhydrase 9 is dependent on the unfolded protein response
    Twan van den Beucken
    Department of Radiation Oncology Maastro Lab, Maastricht University, Maastricht, The Netherlands
    J Biol Chem 284:24204-12. 2009
    ..Through gene expression profiling we discovered that induction of the HIF-1 target gene CA9 was defective in mouse embryo fibroblasts derived from mice harboring an eIF2alpha S51A knock-in mutation...
  17. pmc In vivo identification and specificity assessment of mRNA markers of hypoxia in human and mouse tumors
    Morten Busk
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    BMC Cancer 11:63. 2011
    ..g., low pH). Here we describe a new technique that by exploiting intratumoral oxygenation heterogeneity allows us to identify and objectively rank the most robust mRNA hypoxia biomarkers...
  18. pmc T tubules and surface membranes provide equally effective pathways of carbonic anhydrase-facilitated lactic acid transport in skeletal muscle
    Janine Hallerdei
    Molecular and Cell Physiology, Vegetative Physiologie, Medizinische Hochschule Hannover, Hannover, Germany
    PLoS ONE 5:e15137. 2010
    ..CA) of EDL in lactic acid transport was investigated by measuring lactate flux in muscles from wildtype, CAIV-, CAIX- and CAXIV-single ko, CAIV-CAXIV double ko and CAIV-CAIX-CAXIV-triple ko mice...
  19. pmc Global transcriptional response to carbonic anhydrase IX deficiency in the mouse stomach
    Heini Kallio
    Institute of Medical Technology and School of Medicine, University of Tampere, Biokatu 6, FI 33520 Tampere, Finland
    BMC Genomics 11:397. 2010
    Carbonic anhydrases (CAs) are a family of enzymes that regulate pH homeostasis in various tissues. CA IX is an exceptional member of this family because in addition to the basic CA function, it has been implicated in several other ..
  20. pmc The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism
    Na Zhang
    Molecular Biology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    Cell Metab 11:364-78. 2010
    ..These results demonstrate that FIH acts to a significant degree through the nervous system to regulate metabolism...
  21. ncbi Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway
    Patrick J Pollard
    Molecular and Population Genetics Laboratory, Histopathology Department, London Research Institute, Cancer Research UK, Hammersmith Hospital, Imperial College London, United Kingdom
    Cancer Cell 11:311-9. 2007
    ..Our mouse may be useful for testing therapeutic interventions that target angiogenesis and HIF-prolyl hydroxylation...
  22. pmc A systematic quantification of carbonic anhydrase transcripts in the mouse digestive system
    Pei wen Pan
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, 33520, Tampere, Finland
    BMC Mol Biol 8:22. 2007
    ..In the present study, we systematically examined the mRNA expression levels of all known CA isozymes by quantitative real-time PCR in eight tissues of the digestive system of male and female mice...
  23. pmc Expression of carbonic anhydrases IX and XII during mouse embryonic development
    Heini Kallio
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, Biokatu 8, FIN 33520 Tampere, Finland
    BMC Dev Biol 6:22. 2006
    Of the thirteen active carbonic anhydrase (CA) isozymes, CA IX and XII have been linked to carcinogenesis...
  24. ncbi Monoclonal antibodies generated in carbonic anhydrase IX-deficient mice recognize different domains of tumour-associated hypoxia-induced carbonic anhydrase IX
    Miriam Zat'ovicová
    Centre of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences, Dubravska cesta 9, 845 05, Bratislava, Slovak Republic
    J Immunol Methods 282:117-34. 2003
    Transmembrane carbonic anhydrase IX (CA IX) is frequently expressed in human tumours in response to hypoxia and may serve as a tumour marker and therapeutic target...