Genomes and Genes
Gene Symbol: Cd44
Description: CD44 antigen
Alias: AU023126, AW121933, AW146109, HERMES, Ly-24, Pgp-1, CD44 antigen, ECMR-III, GP90 lymphocyte homing/adhesion receptor, HUTCH-I, PGP-I, extracellular matrix receptor III, hermes antigen, hyaluronate receptor, lymphocyte antigen 24, phagocytic glycoprotein 1, phagocytic glycoprotein I
Publications150 found, 100 shown here
- CD44v7 interferes with activation-induced cell death by up-regulation of anti-apoptotic gene expressionRachid Marhaba
Department of Tumor Progression and Tumor Defense, German Cancer Research Center, Heidelberg, Germany
J Leukoc Biol 74:135-48. 2003..Thus, as opposed to the CD44 standard isoform, CD44v7 does not function as an accessory molecule; instead, it supports survival of activated T ..
- RHAMM, a receptor for hyaluronan-mediated motility, compensates for CD44 in inflamed CD44-knockout mice: a different interpretation of redundancyShlomo Nedvetzki
The Lautenberg Center for General and Tumor Immunology, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
Proc Natl Acad Sci U S A 101:18081-6. 2004We report here that joint inflammation in collagen-induced arthritis is more aggravated in CD44-knockout mice than in WT mice, and we provide evidence for molecular redundancy as a causal factor...
- Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cellsDaniela S Krause
Molecular Oncology Research Institute, Tufts New England Medical Center, 750 Washington Street, Boston, Massachusetts 02111, USA
Nat Med 12:1175-80. 2006..Here we show that CD44 expression is increased on mouse stem-progenitor cells expressing BCR-ABL and that CD44 contributes functional E-..
- Selective down-regulation of neutrophil Mac-1 in endotoxemic hepatic microcirculation via IL-10Gustavo Batista Menezes
Calvin, Phoebe, and Joan Snyder Institute for Infection, Immunity, and Inflammation, University of Calgary, Alberta, Canada
J Immunol 183:7557-68. 2009Hepatic neutrophil adhesion during endotoxemia is an integrin-independent, CD44-dependent process...
- Resolution of lung inflammation by CD44Priit Teder
Department of Medicine, Pulmonary and Critical Care Section, Yale University School of Medicine, New Haven, CT 06520, USA
Science 296:155-8. 2002..We have examined whether the cell-surface adhesion molecule and hyaluronan receptor CD44 plays a role in resolving lung inflammation...
- Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1Alexander Zarbock
Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
Immunity 26:773-83. 2007..This identifies a second neutrophil-activation pathway that is as important as activation through G protein-coupled receptors (GPCRs)...
- Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1)C G Lee
Yale University School of Medicine, Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, New Haven, CT 06520 8057, USA
J Exp Med 194:809-21. 2001..protein-1 and increased mRNA encoding urinary plasminogen activator, matrix metalloproteinase (MMP)-9, and CD44. TGF-beta(1) activation was abrogated by the plasmin/serine protease antagonist aprotinin...
- Successful elimination of memory-type CD8+ T cell subsets by the administration of anti-Gr-1 monoclonal antibody in vivoJunko Matsuzaki
Division of Immunoregulation, Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, 060 0815, Hokkaido, Sapporo, Japan
Cell Immunol 224:98-105. 2003..of Gr-1 antigen on various subsets of mouse spleen cells, we found that Gr-1 was expressed on memory-type CD8(+)CD44(high)CD62L(high) T cells in addition to granulocytes...
- An obligatory role of mind bomb-1 in notch signaling of mammalian developmentBon Kyoung Koo
Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, South Korea
PLoS ONE 2:e1221. 2007..However, the respective roles of the mammalian E3 ubiquitin ligases, Neur1, Neur2, Mib1, and Mib2, in mammalian development are poorly understood...
- E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin alphaLbeta2-mediated slow leukocyte rollingTadayuki Yago
Cardiovascular Biology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
Blood 116:485-94. 2010..In contrast, we found that E-selectin engagement of PSGL-1 or CD44 triggered slow rolling through a common, lipid raft-dependent pathway that used the SFKs Hck and Lyn as well as Fgr...
- Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunityS Ashkar
Laboratory for Skeletal Disorders and Rehabilitation, Department of Orthopedic Surgery, Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
Science 287:860-4. 2000..Eta-1 and its integrin receptor stimulated IL-12 expression, whereas a phosphorylation-independent interaction with CD44 inhibited IL-10 expression...
- Mac-1 (CD11b/CD18) and CD45 mediate the adhesion of hematopoietic progenitor cells to stromal cell elements via recognition of stromal heparan sulfateD R Coombe
Sir William Dunn School of Pathology, University of Oxford, UK
Blood 84:739-52. 1994..The data suggest that heparan sulfate on the 3T3 cell surface is a ligand for both CD45 and Mac-1, but the two molecules recognize different heparan sulfate structural motifs...
- Monocyte trafficking to hepatic sites of bacterial infection is chemokine independent and directed by focal intercellular adhesion molecule-1 expressionChao Shi
Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
J Immunol 184:6266-74. 2010..to foci of bacterial infection in the liver, including on CD31(+) endothelial cells, and blockade of CD11b and CD44 diminishes monocyte localization to these hepatic foci...
- Hypoxia increases Sca-1/CD44 co-expression in murine mesenchymal stem cells and enhances their adipogenic differentiation potentialM G Valorani
Centre for Diabetes, Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
Cell Tissue Res 341:111-20. 2010..reduction of ex vivo expansion time, with significantly increased numbers of Sca-1(+) as well as Sca-1(+)/CD44(+)double-positive cells...
- Cooperation between CD44 and LFA-1/CD11a adhesion receptors in lymphokine-activated killer cell cytotoxicityG Matsumoto
Amgen Institute, and Department of Medical Biophysics and Immunology, University of Toronto, Ontario, Canada
J Immunol 160:5781-9. 1998..We provide genetic evidence in CD44(-/-) and LFA-1(-/-) mice that the cell adhesion receptors LFA-1 and CD44 regulate the cytotoxic activity of IL-2-..
- Inhibition of membrane type-1 matrix metalloproteinase by cancer drugs interferes with the homing of diabetogenic T cells into the pancreasAlexei Y Savinov
The Burnham Institute, La Jolla, California 92037, USA
J Biol Chem 280:27755-8. 2005..We determined that MT1-MMP proteolysis of the T cell surface CD44 adhesion receptor affects the homing of T cells into the pancreas...
- Adamts5 deletion blocks murine dermal repair through CD44-mediated aggrecan accumulation and modulation of transforming growth factor β1 (TGFβ1) signalingJennifer Velasco
Departments of Biochemistry, Rush UniversityMedical Center, Chicago, Illinois 60612, USA
J Biol Chem 286:26016-27. 2011..Aggrecan deposition and impaired dermal repair in Adamts5(-/-) mice are both dependent on CD44, and Cd44(-/-)/Adamts5(-/-) mice display robust activation of TGFβ receptor II and collagen type III expression ..
- c-Met recruits ICAM-1 as a coreceptor to compensate for the loss of CD44 in Cd44 null miceVivienne Olaku
Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, 76344 Eggenstein Leopoldshafen, Germany
Mol Biol Cell 22:2777-86. 2011b>CD44 isoforms act as coreceptors for the receptor tyrosine kinases c-Met and VEGFR-2. However, Cd44 knockout mice do not show overt phenotypes, in contrast to Met and Vegfr-2 knockout mice...
- Role of EGR1 in regulation of stimulus-dependent CD44 transcription in B lymphocytesJ S Maltzman
Department of Pathology and Laboratory Medicine, University of Pennsylvania, School of Medicine, Philadelphia, 19104, USA
Mol Cell Biol 16:2283-94. 1996..Here we identify the gene encoding the lymphocyte homing and migration protein CD44 as a target of EGR1 regulation in B cells...
- The identification of a new alternative exon with highly restricted tissue expression in transcripts encoding the mouse Pgp-1 (CD44) homing receptor. Comparison of all 10 variable exons between mouse, human, and ratG R Screaton
Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom
J Biol Chem 268:12235-8. 1993The human CD44 cell surface glycoprotein family which has been implicated in lymphocyte homing, tumor metastasis, and extracellular matrix attachment consists of a large number of related isoforms that derive from the differential ..
- Insulinoma-associated 1 has a panneurogenic role and promotes the generation and expansion of basal progenitors in the developing mouse neocortexLilla M Farkas
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
Neuron 60:40-55. 2008..Our data imply that Insm1 is involved in the generation and expansion of basal progenitors, a hallmark of neocortex evolution...
- Scc-1, a novel colon cancer susceptibility gene in the mouse: linkage to CD44 (Ly-24, Pgp-1) on chromosome 2C J Moen
Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam
Oncogene 7:563-6. 1992..from the oncogenes and tumor-suppressor genes known to be involved in colon tumorigenesis, in the vicinity of CD44 (Ly-24, Pgp-1) on chromosome 2...
- Cutting edge: LFA-1 is required for liver NK1.1+TCR alpha beta+ cell development: evidence that liver NK1.1+TCR alpha beta+ cells originate from multiple pathwaysT Ohteki
Department of Medical Biophysics, Ontario Cancer Institute, Toronto, Canada
J Immunol 162:3753-6. 1999Using mice deficient for LFA-1, CD44, and ICAM-1, we examined the role of these adhesion molecules in NK1.1+TCR alpha beta+ (NKT) cell development...
- Altered midline axon pathways and ectopic neurons in the developing hypothalamus of netrin-1- and DCC-deficient miceM S Deiner
Departments of Ophthalmology and Physiology, Biomedical Sciences Program, Beckman Vision Center, University of California, San Francisco, San Francisco, California 94143 0730, USA
J Neurosci 19:9900-12. 1999..Netrin protein localization also indicates that unlike in more caudal CNS, guidance about the hypothalamic ventral midline does not require midline expression of netrin...
- Mouse LYVE-1 is an endocytic receptor for hyaluronan in lymphatic endotheliumR Prevo
Medical Research Council Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
J Biol Chem 276:19420-30. 2001..of mouse LYVE-1 remains restricted to the lymphatics in homozygous knockout mice lacking a functional gene for CD44, the closest homologue of LYVE-1 and the only other Link superfamily HA receptor known to date...
- Mechanistic insights into targeting T cell membrane proteinase to promote islet beta-cell rejuvenation in type 1 diabetesAlexei Y Savinov
Burnham Institute for Medical Research, 10901 North Torrey Pines Rd, La Jolla, CA 92037, USA
FASEB J 20:1793-801. 2006..cells as a mediator of pericellular proteolysis and directly cleaves several cell surface receptors, including CD44. In this report, we confirm that adhesion of diabetogenic T cells promotes the activation of endogenous MT1-MMP...
- Selective suppression of CD44 in keratinocytes of mice bearing an antisense CD44 transgene driven by a tissue-specific promoter disrupts hyaluronate metabolism in the skin and impairs keratinocyte proliferationG Kaya
Department of Pathology, University Medical Center, University of Geneva, Switzerland
Genes Dev 11:996-1007. 1997b>CD44 is a broadly distributed polymorphic glycoprotein that serves as the principal cell-surface receptor for hyaluronate...
- GATA-3 regulates the development and function of invariant NKT cellsPeter J Kim
Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
J Immunol 177:6650-9. 2006..In addition, GATA-3 is also required for survival, activation, and effector functions of this unique population of T cells. Our data also reveal a previously unidentified peripheral maturation step that is GATA-3 dependent...
- Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartmentD M Willerford
Howard Hughes Medical Institute, Department of Pediatrics, Children s Hospital, Boston, Massachusetts 02115, USA
Immunity 3:521-30. 1995..Thus, IL-2R alpha is essential for regulation of both the size and content of the peripheral lymphoid compartment, probably by influencing the balance between clonal expansion and cell death following lymphocyte activation...
- CD44 expression on murine tissuesS J Kennel
Oak Ridge National Laboratory, TN 37831 8077
J Cell Sci 104:373-82. 1993b>CD44 is a cell surface glycoprotein found on lymphoid and epithelial cells. Its primary function on lymphocytes and macrophages is to mediate interaction with endothelium, while its function on epithelial cells is not known...
- CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4S K Mendiratta
Howard Hughes Medical Institute, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Immunity 6:469-77. 1997..These results demonstrate a critical role for CD1 in the positive selection and function of NT cells...
- Induction of apoptosis of metastatic mammary carcinoma cells in vivo by disruption of tumor cell surface CD44 functionQ Yu
Molecular Pathology Unit and MGH Cancer Center, Massachusetts General Hospital, Charlestown Navy Yard, Boston, Massachusetts 02129, USA
J Exp Med 186:1985-96. 1997To understand how the hyaluronan receptor CD44 regulates tumor metastasis, the murine mammary carcinoma TA3/St, which constitutively expresses cell surface CD44, was transfected with cDNAs encoding soluble isoforms of CD44 and the ..
- Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasionQ Yu
Molecular Pathology Unit and MGH Cancer Center, Massachusetts General Hospital, and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02129, USA
Genes Dev 13:35-48. 1999The cell surface hyaluronan receptor CD44 promotes tumor growth and metastasis by mechanisms that remain poorly understood...
- CD44-deficient mice develop normally with changes in subpopulations and recirculation of lymphocyte subsetsU Protin
Boehringer Ingelheim Pharma KG, Germany
J Immunol 163:4917-23. 1999..The transmembrane glycoprotein CD44, which is expressed in numerous splice variants on the surface of many different cell types and tissues, has been ..
- CD44 variant-specific antibodies trigger hemopoiesis by selective release of cytokines from bone marrow macrophagesSophia Khaldoyanidi
Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, and University of Karlsruhe, Institute of Genetics, Karlsruhe, Germany
Blood 99:3955-61. 2002..Using long-term bone marrow cultures, we show here that monoclonal antibodies directed against the CD44 v4 and CD44 v6 epitopes stimulate myelopoiesis (CD44 v4 and CD44 v6) and lymphopoiesis (CD44 v6)...
- Trafficking of CD44-deficient murine lymphocytes under normal and inflammatory conditionsReinout Stoop
Section of Biochemistry and Molecular Biology, Department of Orthopedic Surgery, Rush University at Rush Presbyterian St Luke s Medical Center, Chicago 60612, USA
Eur J Immunol 32:2532-42. 2002b>CD44 has been implicated in hyaluronan (HA)-dependent primary adhesion between leukocytes and endothelium...
- CD44 deficiency leads to enhanced neutrophil migration and lung injury in Escherichia coli pneumonia in miceQin Wang
Department of Pediatrics, Division of Integrative Biology, Rainbow Babies and Children s Hospital, 11100 Euclid Avenue, Cleveland, OH 44106, USA
Am J Pathol 161:2219-28. 2002b>CD44 is a major cell-surface receptor for hyaluronic acid (HA), a glycosaminoglycan component of extracellular matrix. HA-CD44 interactions have been implicated in leukocyte extravasation into an inflammatory site...
- Wnt/beta-catenin signaling is sufficient and necessary for synovial joint formationXizhi Guo
Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA
Genes Dev 18:2404-17. 2004..Wnt4, Wnt14, and Wnt16 may play redundant roles in synovial joint induction by signaling through the beta-catenin-mediated canonical Wnt pathway...
- Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutantsLuke T Krebs
The Jackson Laboratory, Bar Harbor, Maine 04609, USA
Genes Dev 18:2469-73. 2004..These results demonstrate that vascular remodeling in the mouse embryo is sensitive to Dll4 gene dosage and that Notch activation in endothelial cells is essential for embryonic vascular remodeling...
- Role of CD44 and hyaluronan in neutrophil recruitmentAdil I Khan
Immunology Research Group, Department of Physiology and Biophysics, University of Calgary Medical Center, Calgary, Canada
J Immunol 173:7594-601. 2004Lymphocyte CD44 interactions with hyaluronan localized on the endothelium have been demonstrated to mediate rolling and regulate lymphocyte entry into sites of chronic inflammation...
- CD44 attenuates metastatic invasion during breast cancer progressionJose I Lopez
Department of Molecular and Cellular Biology and Arizona Cancer Center, Tucson, AZ 85724, USA
Cancer Res 65:6755-63. 2005Metastatic invasion is the primary cause of breast cancer mortality, and adhesion receptors, such as CD44, are believed to be critical in this process...
- SHAP potentiates the CD44-mediated leukocyte adhesion to the hyaluronan substratumLisheng Zhuo
Institute for Molecular Science of Medicine, Aichi Medical University, Nagakute, Aichi 480 1195, Japan
J Biol Chem 281:20303-14. 2006b>CD44-hyaluronan (HA) interaction is involved in diverse physiological and pathological processes. Regulation of interacting avidity is well studied on CD44 but rarely on HA...
- Involvement of endothelial CD44 during in vivo angiogenesisGaoyuan Cao
Pulmonary, Allergy and Critical Care Division, Department of Medicine, Division of Neonatology, Children s Hospital of Philadelphia, Philadelphia, PA, USA
Am J Pathol 169:325-36. 2006b>CD44, a cell-surface receptor for hyaluronan, has been implicated in endothelial cell functions, but its role in the formation of blood vessels in vivo has not been established...
- Targeting of CD44 eradicates human acute myeloid leukemic stem cellsLiqing Jin
Division of Cell and Molecular Biology, University Health Network Suite 8 355, Toronto Medical Discovery Tower, 101 College Street, Toronto, M5G 1L7, Canada
Nat Med 12:1167-74. 2006..We report a therapeutic approach using an activating monoclonal antibody directed to the adhesion molecule CD44. In vivo administration of this antibody to nonobese diabetic-severe combined immune-deficient mice transplanted ..
- CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complexXuerong Shi
Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Immunity 25:595-606. 2006..We hypothesized that signaling requires an additional molecule such as CD44, which activates nonreceptor tyrosine kinases...
- CD44-mediated phagocytosis induces inside-out activation of complement receptor-3 in murine macrophagesEric Vachon
Division of Respirology, Department of Medicine, University of Toronto, Toronto, ON, Canada
Blood 110:4492-502. 2007..b>CD44, a transmembrane adhesion molecule involved in binding and metabolism of hyaluronan, may have additional functions ..
- Interaction of CD44 and hyaluronan is the dominant mechanism for neutrophil sequestration in inflamed liver sinusoidsBraedon McDonald
Immunology Research Group, Department of Physiology and Biophysics, Institute of Infection, Immunity and Inflammation, University of Calgary, Alberta T2N 4N1, Canada
J Exp Med 205:915-27. 2008..Blocking CD44-HA interactions reduced neutrophil adhesion in the sinusoids of endotoxemic mice, with no effect on rolling or ..
- Role of CD44 in CTL-induced acute liver injury in hepatitis B virus transgenic miceKiminori Kimura
Division of Hepatology, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, 3 18 22 Honkomagome, Bunkyo ku, Tokyo, 113 8677, Japan
J Gastroenterol 44:218-27. 2009..We examined the role of CD44 in these interactions using the hepatitis model.
- Characterization of a CD44/CD122int memory CD8 T cell subset generated under sterile inflammatory conditionsFlorentin Martial Mbitikon-Kobo
Universite de Lyon, France
J Immunol 182:3846-54. 2009..The corresponding memory CD8 T cells can be identified by their intermediate expression levels of CD44 and CD122...
- Engagement of CD44 by hyaluronan suppresses TLR4 signaling and the septic response to LPSJun Muto
Division of Dermatology, University of California, San Diego and VA San Diego Health Care System, San Diego, CA 92161, USA
Mol Immunol 47:449-56. 2009Fragments of hyaluronan released after injury bind and activate TLR4 in a complex with CD44. Here we investigated if the recognition of hyaluronan by CD44 and TLR4 alters lipopolysaccharide (LPS) responsiveness and thus could alter the ..
- CD44 deficiency is associated with enhanced Escherichia coli-induced proinflammatory cytokine and chemokine release by peritoneal macrophagesGerritje J W van der Windt
Center of Infection and Immunity Amsterdam, Academic Medical Center, Meibergdreef 9, Room G2 132, 1105 AZ Amsterdam, The Netherlands
Infect Immun 78:115-24. 2010b>CD44 is involved in several immune responses, such as cellular adhesion, migration, proliferation, and activation. Peritonitis is an important cause of sepsis, and Escherichia coli is one of the major pathogens involved therein...
- CD44 and hyaluronan promote invasive growth of B35 neuroblastoma cells into the brainAnnette Pusch
Institut fur Biochemie und Molekularbiologie, Rheinische Friedrich Wilhelms Universitat Bonn, Nussallee 11, D 53115 Bonn, Germany
Biochim Biophys Acta 1803:261-74. 2010Hyaluronan and its receptor CD44 are known to contribute to the invasive growth of different tumors of the central nervous system. It is not known, however, if CD44 is sufficient to activate invasive growth into the brain tissue...
- CD44 interacts directly with Lck in a zinc-dependent mannerDennis C Lefebvre
Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada
Mol Immunol 47:1882-9. 2010b>CD44 is a widely expressed cell adhesion molecule with functional similarities to the selectin and integrin adhesion molecules. CD44 has a lectin domain that binds hyaluronan, a component of the extracellular matrix...
- CD44 deficiency is associated with increased bacterial clearance but enhanced lung inflammation during Gram-negative pneumoniaGerritje J W van der Windt
Center for Infection and Immunity Amsterdam, Department of Pathology, Academic Medical Center, Meibergdreef 9, Room G2 130, 1105 AZ Amsterdam, The Netherlands
Am J Pathol 177:2483-94. 2010Klebsiella pneumoniae is a frequently isolated causative pathogen in respiratory tract infections. CD44 is a transmembrane adhesion molecule that has been implicated in several immunological processes...
- Severe lung fibrosis requires an invasive fibroblast phenotype regulated by hyaluronan and CD44Yuejuan Li
Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA
J Exp Med 208:1459-71. 2011..Both the invasive phenotype and the progressive fibrosis were inhibited in the absence of CD44. Treatment with a blocking antibody to CD44 reduced lung fibrosis in mice in vivo...
- Characterization of soluble CD44 in the circulation of mice. Levels are affected by immune activity and tumor growthS Katoh
Oklahoma Medical Research Foundation, Oklahoma City 73104
J Immunol 153:3440-9. 1994ELISA determinations revealed substantial concentrations (0.49 to 2.10 micrograms/ml) of soluble CD44 in murine serum, with some variation among normal mouse strains...
- A new alternatively spliced exon between v9 and v10 provides a molecular basis for synthesis of soluble CD44Q Yu
Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
J Biol Chem 271:20603-7. 1996The numerous isoforms of murine CD44 contain a common peptide region that is encoded by exons 1-5, 16-18, and 20 and variant regions derived from exons 6-15, usually referred to as v1-v10...
- CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicityR Schmits
Amgen Institute, Toronto, Ontario, Canada
Blood 90:2217-33. 1997b>CD44 is expressed in various isoforms on numerous cell types and tissues during embryogenesis and in the mature organism. CD44 may also be involved in tumor growth...
- A splice variant of CD44 expressed in the apical ectodermal ridge presents fibroblast growth factors to limb mesenchyme and is required for limb outgrowthL Sherman
Forschungszentrum Karlsruhe, Institut fur Genetik, D 76021 Karlsruhe, Germany
Genes Dev 12:1058-71. 1998..We report here that a specific CD44 splice variant is crucial for the proliferation of these mesenchymal cells...
- Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathwayV J Wielenga
Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
Am J Pathol 154:515-23. 1999Overexpression of cell surface glycoproteins of the CD44 family is an early event in the colorectal adenoma-carcinoma sequence...
- CD44-deficient mice exhibit enhanced hepatitis after concanavalin A injection: evidence for involvement of CD44 in activation-induced cell deathD Chen
Departments of Microbiology and Immunology and Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
J Immunol 166:5889-97. 2001..In the current study, we investigated the role of CD44 in Con A-induced hepatitis...
- Increased resistance to collagen-induced arthritis in CD44-deficient DBA/1 miceR Stoop
Rush Medical College at Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
Arthritis Rheum 44:2922-31. 2001To study the role of CD44, the principal hyaluronan (HA) receptor, in experimental arthritis.
- CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodelingWei Hsuan Yu
Molecular Pathology Unit, Massachusetts General Hospital, and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02129, USA
Genes Dev 16:307-23. 2002b>CD44 is a facultative proteoglycan implicated in cell adhesion and trafficking, as well as in tumor survival and progression...
- Involvement of CD44 in leukocyte trafficking at the blood-retinal barrierHeping Xu
Department of Ophthalmology, Aberdeen University Medical School, Scotland, United Kingdom
J Leukoc Biol 72:1133-41. 2002In the present study, we investigated the involvement of CD44 in leukocyte trafficking in vivo at the blood-retinal barrier using experimental autoimmune uveoretinitis (EAU) as a model system...
- Rho-dependent Rho kinase activation increases CD44 surface expression and bone resorption in osteoclastsMeenakshi A Chellaiah
Department of Oral Craniofacial Biological Sciences, University of Maryland, Baltimore, Maryland 21201, USA
J Biol Chem 278:29086-97. 2003Osteoclasts from osteopontin-deficient mice exhibit decreased CD44 surface expression [corrected]. Osteopontin (OPN)/alphavbeta3 generated Rho signaling pathway is required for the surface expression of CD44...
- Hepatocyte growth factor enhances adhesion of breast cancer cells to endothelial cells in vitro through up-regulation of CD44Shinichiro Mine
The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health Japan, 1 1 Iseigaoka, Yahata Nishi, Kitakyushu 807 8555, Japan
Exp Cell Res 288:189-97. 2003..showed the following features of breast cancer cells: (1) HGF stimulated breast cancer cells by up-regulating CD44 expression in a concentration-dependent manner...
- CD44 expression identifies astrocyte-restricted precursor cellsYing Liu
Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, Baltimore, MD 21224, USA
Dev Biol 276:31-46. 2004..We show that CD44 identifies an astrocyte-restricted precursor cell (ARP) that is committed to generating astrocytes in vitro and in ..
- Hyaluronan increases RANKL expression in bone marrow stromal cells through CD44Jay J Cao
Division of Endocrinology, Veterans Affairs Medical Center, San Francisco, California 94121, USA
J Bone Miner Res 20:30-40. 2005HA activates CD44 to stimulate RANKL expression in bone marrow stromal cells. HA stimulation of RANKL is blocked by anti-CD44 antibody and is absent in cells from CD44(-/-) mice...
- CD44v6 promotes proliferation by persisting activation of MAP kinasesRachid Marhaba
Department of Tumor Progression and Tumor Defense, German Cancer Research Center, Heidelberg
Cell Signal 17:961-73. 2005..The underlying mechanism is unknown. The mouse thymoma EL4 was transfected with CD44 standard isoform (CD44s) or CD44v6 cDNA (EL4-s, EL4-v6)...
- Protection against renal ischemia reperfusion injury by CD44 disruptionKasper M A Rouschop
Department of Pathology, Academic Medical Center, P O Box 22660, 1100 DD, Amsterdam, The Netherlands
J Am Soc Nephrol 16:2034-43. 2005..The inflammatory infiltrate mainly consists of neutrophils, which are deleterious for the renal tissue. Because CD44 is expressed by neutrophils and is rapidly upregulated by capillary endothelial cells after I/R injury, it was ..
- Regulation of lung injury and repair by Toll-like receptors and hyaluronanDianhua Jiang
Department of Medicine, Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
Nat Med 11:1173-9. 2005..Hyaluronan-TLR2 and hyaluronan-TLR4 interactions provide signals that initiate inflammatory responses, maintain epithelial cell integrity and promote recovery from acute lung injury...
- Use of CD44 by CD4+ Th1 and Th2 lymphocytes to roll and adhereClaudine S Bonder
Department of Physiology and Biophysics, Univeristy of Calgary, AB, Canada
Blood 107:4798-806. 2006..using cell lines have previously demonstrated that rolling and adhesion of lymphocytes on endothelium requires CD44 interactions with hyaluronan (HA)...
- Hyaluronate fragments reverse skin atrophy by a CD44-dependent mechanismGürkan Kaya
Department of Dermatology, University of Geneva, Geneva, Switzerland
PLoS Med 3:e493. 2006..With an increasingly aging patient population, management of skin atrophy is becoming a major challenge in the clinic, particularly in light of the fact that there are no effective therapeutic options at present...
- Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on Toll-like receptor 4, CD44, and MD-2Kristen R Taylor
Division of Dermatology, University of California, San Diego and Veterans Affairs Medical Center, San Diego, California 92161, USA
J Biol Chem 282:18265-75. 2007..Explanation for the unique response to hyaluronan was provided by observations that a lack of TLR4 or CD44 in mice diminished the response to sterile injury, and together with MD-2, was required for responsiveness to ..
- Complete identification of E-selectin ligands on neutrophils reveals distinct functions of PSGL-1, ESL-1, and CD44Andres Hidalgo
Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Immunity 26:477-89. 2007..Here, we showed that E-selectin ligand-1 (ESL-1), P-selectin glycoprotein ligand-1 (PSGL-1), and CD44 encompassed all endothelial-selectin ligand activity on neutrophils by using gene- and RNA-targeted loss of ..
- CD44 suppresses TLR-mediated inflammationHidetada Kawana
Department of Molecular and Tumor Pathology, Chiba University Graduate School of Medicine, Inohana, Chuo Ku, Chiba, Japan
J Immunol 180:4235-45. 2008The cell adhesion molecule CD44, which is the major hyaluronan receptor, has been implicated in the binding, endocytosis, and metabolism of hyaluronan...
- Fibroblast migration is mediated by CD44-dependent TGF beta activationPinak S Acharya
Department of Pulmonary and Critical Care Medicine, The University of Pennsylvania, Philadelphia, PA 19104, USA
J Cell Sci 121:1393-402. 2008b>CD44 contributes to inflammation and fibrosis in response to injury. As fibroblast recruitment is critical to wound healing, we compared cytoskeletal architecture and migration of wild-type (CD44WT) and CD44-deficient (CD44KO) fibroblasts...
- In the limb AER Bmp2 and Bmp4 are required for dorsal-ventral patterning and interdigital cell death but not limb outgrowthDanielle M Maatouk
Department of Molecular Genetics and Microbiology and the Genetics Institute, University of Florida, College of Medicine, Gainesville, FL 32611, USA
Dev Biol 327:516-23. 2009..Our data suggests that AER expression of Bmp2 and Bmp4 is required for digit and dorsal-ventral patterning but surprisingly not for limb outgrowth...
- CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progressionRhonda L Brown
Department of Medicine, Division of Hematology Oncology, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60614, USA
J Clin Invest 121:1064-74. 2011..Here we show that a switch in CD44 alternative splicing is required for EMT...
- CD44 plays a critical role in regulating diet-induced adipose inflammation, hepatic steatosis, and insulin resistanceHong Soon Kang
Cell Biology Section, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
PLoS ONE 8:e58417. 2013b>CD44 is a multifunctional membrane receptor implicated in the regulation of several biological processes, including inflammation...
- Mouse strain variation in Ly-24 (Pgp-1) expression by peripheral T cells and thymocytes: implications for T cell differentiationF Lynch
Department of Experimental Pathology, John Curtin School of Medical Research, Canberra, Australia
Eur J Immunol 19:223-9. 1989..Expression of Ly-24 by thymocytes is discussed in the context of current models of intrathymic T cell differentiation...
- Restricted expression of the hyaluronan receptor, CD44, during postimplantation mouse embryogenesis suggests key roles in tissue formation and patterningS C Wheatley
Department of Biology, Imperial College of Science, Technology and Medicine, London, UK
Development 119:295-306. 1993b>CD44 is a multifunctional adhesion protein that acts as a major receptor for the hygroscopic extracellular matrix component, hyaluronan...
- The adhesion receptor CD44 promotes atherosclerosis by mediating inflammatory cell recruitment and vascular cell activationC A Cuff
The Wistar Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Clin Invest 108:1031-40. 2001..b>CD44 is an adhesion protein expressed on inflammatory and vascular cells...
- Osteopontin modulates CD44-dependent chemotaxis of peritoneal macrophages through G-protein-coupled receptors: evidence of a role for an intracellular form of osteopontinBaoqian Zhu
CIHR Group in Matrix Dynamics, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada
J Cell Physiol 198:155-67. 2004..Acting through integrin alpha(v)beta(3) and CD44 receptors, OPN can promote chemoattraction and pro-inflammatory cytokine expression by macrophages...
- CD44 promotes resistance to apoptosis in murine colonic epitheliumMinalini Lakshman
Department of Laboratory Medicine and Pathobiology, St Michael s Hospital and University of Toronto, Toronto, Ontario, Canada
J Cell Physiol 203:583-8. 2005Dysregulated expression of CD44 isoforms occurs consistently in colon carcinogenesis, and this change occurs also in most other types of cancer...
- Ly6 family member C4.4A binds laminins 1 and 5, associates with galectin-3 and supports cell migrationClaudia Paret
Department of Tumor Progression and Tumor Defense, German Cancer Research Center, Heidelberg, Germany
Int J Cancer 115:724-33. 2005..Our findings that LN1 and LN5 are C4.4A ligands, that galectin-3 associates with C4.4A and that C4.4A ligand binding confers a migratory phenotype are well in line with the supposed metastasis association...
- UVA and UVB decrease the expression of CD44 and hyaluronate in mouse epidermis, which is counteracted by topical retinoidsEmel Calikoglu
Department of Dermatology, DHURDV, University Hospital of Geneva, Geneva, Switzerland
Photochem Photobiol 82:1342-7. 2006The transmembrane glycoprotein CD44 is currently thought to be the main cell surface receptor for the glycosaminoglycan hyaluronate...
- Urothelial CD44 facilitates Escherichia coli infection of the murine urinary tractKasper M A Rouschop
Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
J Immunol 177:7225-32. 2006..We report that CD44, a hyaluronic acid (HA) binding protein that mediates cell-cell and cell-matrix interactions, facilitates the ..
- CD44 regulates macrophage recruitment to the lung in lipopolysaccharide-induced airway diseaseJohn W Hollingsworth
Division of Pulmonary, Allergy, and Critical Care Medicine, DUMC 3136, Duke University Medical Center, Durham, NC 27710, USA
Am J Respir Cell Mol Biol 37:248-53. 2007..In these regions, 28 genes had altered RNA expression after inhalation of LPS, including CD44, which was associated with differences in both TNF-alpha levels and neutrophil recruitment into the lung...
- Expression of a specific subset of CD44 variant transcripts in NOD pancreatic isletsK F Milde
Diabetes Research Institute, University of Miami School of Medicine, Florida 33101, USA
Diabetes 45:718-24. 1996..An overexpression of the lymphocyte surface molecule CD44 in infiltrated NOD islets compared with peripheral blood lymphocytes was recently reported...
- The characterization of a human RHAMM cDNA: conservation of the hyaluronan-binding domainsC Wang
Department of Pediatrics and Physiology, Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada
Gene 174:299-306. 1996..The overall homology between the overlapping region of human and mouse RHAMM v4 cDNA clone is 85%, but the HA binding motif (B[X7]B), shown to be critical for the signaling capability of this receptor, is 100% conserved...
- Lmo2 and GATA-3 associated expression in intraembryonic hemogenic sitesA Manaia
Institut d Embryologie Cellulaire et Moléculaire du CNRS et du Collège de France 49bis, av de la Belle Gabrielle, France
Development 127:643-53. 2000..A combined in situ and immunocytological analysis strongly suggests that ventral mesodermal GATA-3 patches are involved in the process of intraembryonic stem cell generation...
- Genetic and biochemical characterization of antigens encoded by the Ly-24 (Pgp-1) locusV R Sutton
Department of Pathology, University of Melbourne, Parkville, Victoria, Australia
J Immunogenet 14:43-57. 1987..The possible reason for this unusual finding is discussed...
- Gene for a major cell surface glycoprotein of mouse macrophages and other phagocytic cells is on chromosome 2A Colombatti
Proc Natl Acad Sci U S A 79:1926-9. 1982..Another gene on chromosome 2, Ly-m11, was also typed by using (BALB/cJ x C57BL/6J)F1 x C57BL/6J mice. The data from both of these crosses indicated the following gene order: Hc--Pgp-1--Ly-m11--a...
- Localization of hyaluronan in mouse embryos during implantation, gastrulation and organogenesisB A Fenderson
Department of Pathology and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107
Differentiation 54:85-98. 1993Hyaluronan was localized in postimplantation mouse embryos using CD44, the principal hyaluronan receptor...
- Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient miceW L Hazenbos
Department of Immunology, University Hospital Utrecht, The Netherlands
Immunity 5:181-8. 1996..These results indicate a prominent role for Fc gamma RIII in inflammatory and anaphylactic responses, making this receptor a potential target in immunotherapy...
- Expression of the transmembrane glycoprotein CD44 and metastasis associated 18A2/MTS1 gene in B16 murine melanoma cellsM S Lakshmi
Cancer Research Unit, Medical School, University of Newcastle upon Tyne, U K
Anticancer Res 17:3451-5. 1997b>CD44 is a transmembrane cell adhesion-mediating protein which occurs as alternatively spliced isoforms in a variety of cell types...
- Hyaluronan binding properties of a CD44 chimera containing the link module of TSG-6Jayne Lesley
Molecular and Cell Biology Laboratory, Salk Institute, San Diego, California 92186, USA
J Biol Chem 277:26600-8. 2002b>CD44, a cell-surface receptor for the extracellular matrix glycosaminoglycan hyaluronan, can mediate leukocyte rolling on hyaluronan substrates and has been implicated in leukocyte migration to sites of inflammation...
- The role of CD44 in the development and prognosis of head and neck squamous cell carcinomasD Assimakopoulos
Department of Otorhinolaryngology, University of Ioannina Medical School, 45 110 Ioannina, Greece
Histol Histopathol 17:1269-81. 2002b>CD44, the product of a single gene, exists as several isoforms generated by alternative exon splicing and posttranslational modifications, and is widely distributed in different cells and tissues including those of squamocellular origin...
- Role of the extracellular and cytoplasmic domains of CD44 in the rolling interaction of lymphoid cells with hyaluronan under physiologic flowIstvan Gal
Department of Orthopedic Surgery, Section of Biochemistry and Molecular Biology, Rush University at Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
J Biol Chem 278:11150-8. 2003b>CD44 can function as an adhesion receptor that mediates leukocyte rolling on hyaluronan (HA)...
- Role of CD44 and hyaluronic acid (HA) in activation of alloreactive and antigen-specific T cells by bone marrow-derived dendritic cellsYoonkyung Do
Department of Microbiology and Immunology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298 0678, USA
J Immunother 27:1-12. 2004In the current study, the role played by hyaluronic acid (HA) and its receptor CD44 on the activation and functions of dendritic cells (DCs) was investigated...
- CD44-P185HER2 INTERACTION IN OVARIAN CANCER PROGRESSIONLILLY BOURGUIGNON; Fiscal Year: 2007Both CD44 and p185HER2 confer the malignant properties of abnormal cell growth, migration and invasion...
- Regulation of Signaling in Osteoclast Bone ResorptionMeenakshi Chellaiah; Fiscal Year: 2007..abstract_text> ..
- CD44/VARIANT CYTOSKELETON IN BREAST CANCER PROGRESSIONLILLY YW BOURGUIGNON; Fiscal Year: 2010..Our laboratory has determined that overexpression of CD44 variant (CD44v) isoforms [hyaluronan (HA) receptors] appears to confer the malignant properties of increased growth,..
- Invasion of C. neoformans into brain endothelial cellsAmbrose Jong; Fiscal Year: 2008..neoformans binding to HBMEC using an in vitro BBB model. Furthermore, our studies showed that CD44 was the primary receptor on HBMEC for C. neoformans adhesion. Upon C...
- STABILIZATION OF THE CUMULUS ECM AND OVULATIONLarry Sherman; Fiscal Year: 2002..4) The studies may also elucidate aspects of IalphaI/PalphaI function relevant to functions of extracellular matrix in other tissues. ..
- The function of membrane vesiculation in CTLA-4-mediate*Joonsoo Kang; Fiscal Year: 2005..To date there has been limited advancement on the ability to increase CTLA-4 function. The proposed model of CTLA-4 function would provide a novel means to increase CTLA-4-mediated inhibition in vivo. ..
- ROLE OF CD44 IN PERIPHERAL NERVE DEVELOPMENT AND INJURYLarry Sherman; Fiscal Year: 2004The principle goal of the proposed studies is to elucidate the role of the CD44 family of transmembrane glycoproteins in perpheral nerves during development and following injury...
- Hyaluronate in aging-related gliosis and demyelinationLarry Sherman; Fiscal Year: 2005..In neurodegenerative conditions, glial cells overexpress the CD44 transmembrane glycoprotein, a receptor for HA...
- Suppression of EAE by placentally derived glycoproteinLarry Sherman; Fiscal Year: 2005..New directions in basic and clinical research are likely to be discovered and we anticipate the future submission of an RO 1 or program project grant to explore these new frontiers. ..
- Phytoestrogens as an alternative treatment for MSLarry Sherman; Fiscal Year: 2006..unreadable] [unreadable]..
- Determination of Mechanism of T cell Lineage CommittmentJoonsoo Kang; Fiscal Year: 2006..The long-term objective of this application is to identify genes that determine T cell lineage fate. ..
- Mechanisms of CTLA-4 FunctionJoonsoo Kang; Fiscal Year: 2007..Understanding these processes is critical for designing novel therapeutic approaches for vaccine development, autoimmune disease, and in transplant and tumor immunology. ..
- Effects of hyaluronan on neural stem cell homing and differentiationLarry Sherman; Fiscal Year: 2008..The major receptor for HA, the CD44 transmembrane glycoprotein, is expressed by activated T cells and by NSCs, and has been implicated in T cell ..
- Regulation of T cell development by SOX13Joonsoo Kang; Fiscal Year: 2009..Collectively, the genetic program controlling T cell lineage commitment and maturation will be determined, allowing a better understanding of leukemogenesis. ..