Clec9a

Summary

Gene Symbol: Clec9a
Description: C-type lectin domain family 9, member a
Alias: 9830005G06Rik, DNGR-1, C-type lectin domain family 9 member A, dendritic cell natural killer lectin group receptor 1
Species: mouse

Top Publications

  1. pmc Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin
    David Sancho
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom
    J Clin Invest 118:2098-110. 2008
  2. pmc The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement
    Irina Caminschi
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Blood 112:3264-73. 2008
  3. pmc Identification of a dendritic cell receptor that couples sensing of necrosis to immunity
    David Sancho
    Immunobiology Laboratory, London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Nature 458:899-903. 2009
  4. pmc CLEC9A is a novel activation C-type lectin-like receptor expressed on BDCA3+ dendritic cells and a subset of monocytes
    Cristal Huysamen
    Division of Immunology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, 7925, South Africa
    J Biol Chem 283:16693-701. 2008
  5. doi DNGR-1(+) dendritic cells are located in meningeal membrane and choroid plexus of the noninjured brain
    Elena Quintana
    Neuroinflammation Unit Unidad Funcional De Investigación De Enfermedades Crónicas, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    Glia 63:2231-48. 2015
  6. doi GM-CSF Mouse Bone Marrow Cultures Comprise a Heterogeneous Population of CD11c(+)MHCII(+) Macrophages and Dendritic Cells
    Julie Helft
    Immunobiology Laboratory, The Francis Crick Institute, Lincoln s Inn Fields Laboratory, 44 Lincoln s Inn Fields, London WC2A 3LY, UK
    Immunity 42:1197-211. 2015
  7. pmc Structure of the Complex of F-Actin and DNGR-1, a C-Type Lectin Receptor Involved in Dendritic Cell Cross-Presentation of Dead Cell-Associated Antigens
    Pavel Hanč
    Immunobiology Laboratory, The Francis Crick Institute, Lincoln s Inn Fields Laboratory, 44 Lincoln s Inn Fields, London WC2A 3LY, UK
    Immunity 42:839-49. 2015
  8. pmc Altered lymph node composition in diphtheria toxin receptor-based mouse models to ablate dendritic cells
    Janneke van Blijswijk
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3LY, United Kingdom
    J Immunol 194:307-15. 2015
  9. doi DNGR-1 is dispensable for CD8+ T-cell priming during respiratory syncytial virus infection
    Lydia R Durant
    Centre for Respiratory Infections, Section of Respiratory Infections, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK
    Eur J Immunol 44:2340-8. 2014
  10. doi F-actin is an evolutionarily conserved damage-associated molecular pattern recognized by DNGR-1, a receptor for dead cells
    Susan Ahrens
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London, UK
    Immunity 36:635-45. 2012

Detail Information

Publications20

  1. pmc Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin
    David Sancho
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom
    J Clin Invest 118:2098-110. 2008
    ..We conclude that DNGR-1 is a novel, highly specific marker of mouse and human DC subsets that can be exploited for CTL cross-priming and tumor therapy...
  2. pmc The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement
    Irina Caminschi
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Blood 112:3264-73. 2008
    A novel dendritic cell (DC)-restricted molecule, Clec9A, was identified by gene expression profiling of mouse DC subtypes. Based on sequence similarity, a human ortholog was identified...
  3. pmc Identification of a dendritic cell receptor that couples sensing of necrosis to immunity
    David Sancho
    Immunobiology Laboratory, London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Nature 458:899-903. 2009
    ..Here we show that CD8alpha+ dendritic cells use CLEC9A (also known as DNGR-1), a recently-characterized C-type lectin, to recognize a preformed signal that is exposed on ..
  4. pmc CLEC9A is a novel activation C-type lectin-like receptor expressed on BDCA3+ dendritic cells and a subset of monocytes
    Cristal Huysamen
    Division of Immunology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, 7925, South Africa
    J Biol Chem 283:16693-701. 2008
    We describe here the first characterization of CLEC9A, a group V C-type lectin-like receptor located in the "Dectin-1 cluster" of related receptors, which are encoded within the natural killer (NK)-gene complex...
  5. doi DNGR-1(+) dendritic cells are located in meningeal membrane and choroid plexus of the noninjured brain
    Elena Quintana
    Neuroinflammation Unit Unidad Funcional De Investigación De Enfermedades Crónicas, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    Glia 63:2231-48. 2015
    ..C-type lectin receptor family 9, member A (DNGR-1/CLEC9A) is a marker of specific DC subsets that share functional similarities, such as CD8α(+) DCs in lymphoid tissues ..
  6. doi GM-CSF Mouse Bone Marrow Cultures Comprise a Heterogeneous Population of CD11c(+)MHCII(+) Macrophages and Dendritic Cells
    Julie Helft
    Immunobiology Laboratory, The Francis Crick Institute, Lincoln s Inn Fields Laboratory, 44 Lincoln s Inn Fields, London WC2A 3LY, UK
    Immunity 42:1197-211. 2015
    ..These results have important implications for the interpretation of a vast array of data obtained with DC culture systems. ..
  7. pmc Structure of the Complex of F-Actin and DNGR-1, a C-Type Lectin Receptor Involved in Dendritic Cell Cross-Presentation of Dead Cell-Associated Antigens
    Pavel Hanč
    Immunobiology Laboratory, The Francis Crick Institute, Lincoln s Inn Fields Laboratory, 44 Lincoln s Inn Fields, London WC2A 3LY, UK
    Immunity 42:839-49. 2015
    ..Our findings shed light on modes of actin binding by cellular proteins and reveal how extracellular detection of cytoskeletal components by dedicated receptors allows immune monitoring of loss of cellular integrity...
  8. pmc Altered lymph node composition in diphtheria toxin receptor-based mouse models to ablate dendritic cells
    Janneke van Blijswijk
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3LY, United Kingdom
    J Immunol 194:307-15. 2015
    ..It further indicates that DTR, a member of the epidermal growth factor family, is biologically active in mice. Its use in cell ablation experiments needs to be considered in light of this activity. ..
  9. doi DNGR-1 is dispensable for CD8+ T-cell priming during respiratory syncytial virus infection
    Lydia R Durant
    Centre for Respiratory Infections, Section of Respiratory Infections, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK
    Eur J Immunol 44:2340-8. 2014
    ..Thus, direct presentation by DCs may be the major pathway initiating CD8(+) T-cell responses to RSV, while DNGR-1-dependent cross-presentation has no detectable role. ..
  10. doi F-actin is an evolutionarily conserved damage-associated molecular pattern recognized by DNGR-1, a receptor for dead cells
    Susan Ahrens
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London, UK
    Immunity 36:635-45. 2012
    ..In this regard, we have previously described DNGR-1 (CLEC9A) as a DC-restricted receptor specific for an unidentified DAMP that is exposed by necrotic cells and is necessary ..
  11. doi The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments
    Jian Guo Zhang
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    Immunity 36:646-57. 2012
    ..The damaged cell-recognition molecule Clec9A is expressed on the surface of the mouse and human dendritic cell subsets specialized for the uptake and ..
  12. pmc The DC receptor DNGR-1 mediates cross-priming of CTLs during vaccinia virus infection in mice
    Salvador Iborra
    Immunobiology of Inflammation Laboratory, Department of Vascular Biology and Inflammation, Centro Nacional de Investigaciones Cardiovasculares CNIC, Madrid, Spain
    J Clin Invest 122:1628-43. 2012
    ..DNGR-1 (CLEC9A) is a DC-restricted receptor that detects dead cells...
  13. pmc The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice
    Santiago Zelenay
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, UK
    J Clin Invest 122:1615-27. 2012
    DNGR-1 (CLEC9A) is a receptor for necrotic cells required by DCs to cross-prime CTLs against dead cell antigens in mice. It is currently unknown how DNGR-1 couples dead cell recognition to cross-priming...
  14. doi Cutting edge: Clec9A+ dendritic cells mediate the development of experimental cerebral malaria
    Lucia Piva
    School of Biological Sciences, Nanyang Technological University, Singapore 637551
    J Immunol 189:1128-32. 2012
    ..of different dendritic cell (DC) subsets in Plasmodium-induced pathology, we have generated a transgenic strain, Clec9A-diphtheria toxin receptor that allows us to ablate in vivo Clec9A(+) DCs...
  15. doi Genetic tracing via DNGR-1 expression history defines dendritic cells as a hematopoietic lineage
    Barbara U Schraml
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3LY, UK
    Cell 154:843-58. 2013
    ..These studies provide an in vivo model for fate mapping of DCs, distinguishing them from other leukocyte lineages, and thus help to unravel the functional complexity of the mononuclear phagocyte system...
  16. doi DNGR-1 is a specific and universal marker of mouse and human Batf3-dependent dendritic cells in lymphoid and nonlymphoid tissues
    Lionel F Poulin
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London, United Kingdom
    Blood 119:6052-62. 2012
    ..Here we show that mouse CD8α(+) DCs and CD103(+) CD11b(-) DCs can be defined by shared high expression of DNGR-1 (CLEC9A)...
  17. doi Antibody responses initiated by Clec9A-bearing dendritic cells in normal and Batf3(-/-) mice
    Irina Caminschi
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia
    Mol Immunol 50:9-17. 2012
    Injection of antigens coupled to antibodies against the dendritic cell (DC) surface molecule Clec9A has been shown to produce strongly enhanced antibody responses even without co-administration of adjuvants, via antigen presentation by DC ..
  18. pmc Efficient and versatile manipulation of the peripheral CD4+ T-cell compartment by antigen targeting to DNGR-1/CLEC9A
    Olivier P Joffre
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, Lincoln s Inn Fields Laboratories, London, UK
    Eur J Immunol 40:1255-65. 2010
    DC NK lectin group receptor-1 (DNGR-1, also known as CLEC9A) is a C-type lectin receptor expressed by mouse CD8alpha+ DC and by their putative equivalents in human...
  19. doi Targeting antigen to mouse dendritic cells via Clec9A induces potent CD4 T cell responses biased toward a follicular helper phenotype
    Mireille H Lahoud
    Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria 3052, Australia
    J Immunol 187:842-50. 2011
    ..For the production of cytotoxic T cells, DEC-205 and Clec9A, but not Clec12A, were effective targets, although only in the presence of adjuvants...
  20. pmc Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A
    Juliana Idoyaga
    Laboratory of Cellular Physiology and Immunology and the Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 108:2384-9. 2011
    ..Here, we compared the capacity of Langerin/CD207, DEC205/CD205, and Clec9A receptors, each expressed on the CD8(+) DC subset in mice, to bring about immunization of microbial-specific T ..