Cryba4

Summary

Gene Symbol: Cryba4
Description: crystallin, beta A4
Alias: beta-crystallin A4, beta-A4 crystallin
Species: mouse

Top Publications

  1. ncbi Regulation of ocular lens development by Smad-interacting protein 1 involving Foxe3 activation
    Aki Yoshimoto
    Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamadaoka, Suita, Osaka 565 0871, Japan
    Development 132:4437-48. 2005
  2. pmc The orchestration of mammalian tissue morphogenesis through a series of coherent feed-forward loops
    Qing Xie
    Department of Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 286:43259-71. 2011
  3. ncbi The beta crystallin genes on human chromosome 22 define a new region of homology with mouse chromosome 5
    T J Hulsebos
    Institute of Human Genetics, University of Amsterdam, The Netherlands
    Genomics 25:574-6. 1995
  4. ncbi Assignment of the beta B1 crystallin gene (CRYBB1) to human chromosome 22 and mouse chromosome 5
    T J Hulsebos
    Institute of Human Genetics, Academic Medical Center, University of Amsterdam, The Netherlands
    Genomics 29:712-8. 1995
  5. ncbi Molecular cloning, structure, and chromosomal localization of the mouse LIM/homeobox gene Lhx5
    S Bertuzzi
    Laboratory of Mammalian Genes and Development, National Institutes of Health, Bethesda, Maryland, 20892, USA
    Genomics 36:234-9. 1996
  6. ncbi Overlapping effects of different members of the FGF family on lens fiber differentiation in transgenic mice
    F J Lovicu
    Department of Cell Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, TX 77030, USA
    Development 125:3365-77. 1998
  7. ncbi Disruption of Trkb-mediated signaling induces disassembly of postsynaptic receptor clusters at neuromuscular junctions
    M Gonzalez
    Department of Neuroscience University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Neuron 24:567-83. 1999
  8. ncbi Regulation of mouse lens fiber cell development and differentiation by the Maf gene
    B Z Ring
    Department of Pediatrics, Howard Hughes Medical Institute, Stanford, California 94305 5428, USA
    Development 127:307-17. 2000
  9. ncbi Two interactive genes responsible for a new inherited cataract (RCT) in the mouse
    Y Y Maeda
    The Tokyo Metropolitan Institute of Medical Science Rinshoken, Dept of Laboratory Animal Science, Japan
    Mamm Genome 12:278-83. 2001
  10. ncbi Aey2, a new mutation in the betaB2-crystallin-encoding gene of the mouse
    J Graw
    Forschungszentrum für Umwelt und Gesundheit GSF Institute of Experimental Genetics, Neuherberg, Germany
    Invest Ophthalmol Vis Sci 42:1574-80. 2001

Scientific Experts

  • J Graw
  • Y Y Maeda
  • Melinda K Pirity
  • Qing Xie
  • Aki Yoshimoto
  • Jin Na Min
  • Tamio Suzuki
  • P V Dimanlig
  • Ales Cvekl
  • B Z Ring
  • T J Hulsebos
  • P A Overbeek
  • M Gonzalez
  • N A Jenkins
  • F J Lovicu
  • N G Copeland
  • D J Gilbert
  • Yuka Saigou
  • Hisato Kondoh
  • Yujiro Higashi
  • Nahid F Mivechi
  • Demetrius Moskophidis
  • Yan Zhang
  • H Karel Nieuwenhuis
  • Edward K Novak
  • Dorothy C Bennett
  • Bianca Miterski
  • Claudio Castellan
  • Chin To Fong
  • Amna Karim
  • Elena V Sviderskaya
  • Richard T Swank
  • Simon P Hill
  • S Bertuzzi
  • Richard A Spritz
  • Qing Zhang
  • Alex V Levin
  • Wei Li
  • H P Makarenkova
  • R A Lang
  • S C Faber
  • W Auerbach
  • G S Barsh
  • S P Cordes
  • S Kraner
  • M M Rich
  • F P Ruggiero
  • Y J Shi
  • R J Balice-Gordon
  • Q Chang
  • I B Dawid
  • H Z Sheng
  • M Taira
  • H Westphal
  • L J Smink
  • I Dunham
  • A Westerveld
  • G Thomas
  • O Delattre

Detail Information

Publications14

  1. ncbi Regulation of ocular lens development by Smad-interacting protein 1 involving Foxe3 activation
    Aki Yoshimoto
    Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamadaoka, Suita, Osaka 565 0871, Japan
    Development 132:4437-48. 2005
    ..26 kb promoter, and are separate from lens-specific regulation. This is the first demonstration of the significance of Smad interaction in modulating Sip1 activity...
  2. pmc The orchestration of mammalian tissue morphogenesis through a series of coherent feed-forward loops
    Qing Xie
    Department of Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 286:43259-71. 2011
    ....
  3. ncbi The beta crystallin genes on human chromosome 22 define a new region of homology with mouse chromosome 5
    T J Hulsebos
    Institute of Human Genetics, University of Amsterdam, The Netherlands
    Genomics 25:574-6. 1995
    The human beta crystallin genes CRYBB2, CRYBB2P1, CRYBB3, and CRYBA4 are located in 22q11.2. Using interspecific backcross analysis, we mapped the mouse homologues of CRYBB2, CRYBB3, and CRYBA4 (i.e...
  4. ncbi Assignment of the beta B1 crystallin gene (CRYBB1) to human chromosome 22 and mouse chromosome 5
    T J Hulsebos
    Institute of Human Genetics, Academic Medical Center, University of Amsterdam, The Netherlands
    Genomics 29:712-8. 1995
    ..We demonstrate that the beta B1 and beta A4 crystallin genes are very closely linked in the two species...
  5. ncbi Molecular cloning, structure, and chromosomal localization of the mouse LIM/homeobox gene Lhx5
    S Bertuzzi
    Laboratory of Mammalian Genes and Development, National Institutes of Health, Bethesda, Maryland, 20892, USA
    Genomics 36:234-9. 1996
    ..We have mapped Lhx5 to the central region of mouse chromosome 5...
  6. ncbi Overlapping effects of different members of the FGF family on lens fiber differentiation in transgenic mice
    F J Lovicu
    Department of Cell Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, TX 77030, USA
    Development 125:3365-77. 1998
    ..The fact that any of these FGFs can induce ocular defects and loss of lens transparency implies that it is essential for the normal eye to maintain very specific spatial control over FGF expression in order to prevent cataract induction...
  7. ncbi Disruption of Trkb-mediated signaling induces disassembly of postsynaptic receptor clusters at neuromuscular junctions
    M Gonzalez
    Department of Neuroscience University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Neuron 24:567-83. 1999
    ..These results demonstrate a novel role for neurotrophin signaling through TrkB receptors on muscle fibers in the ongoing maintenance of postsynaptic AChR regions...
  8. ncbi Regulation of mouse lens fiber cell development and differentiation by the Maf gene
    B Z Ring
    Department of Pediatrics, Howard Hughes Medical Institute, Stanford, California 94305 5428, USA
    Development 127:307-17. 2000
    ..Our results indicate that Maf directly activates many if not all of the (beta)-crystallin genes, and suggest a model for coordinating cell cycle withdrawal with terminal differentiation...
  9. ncbi Two interactive genes responsible for a new inherited cataract (RCT) in the mouse
    Y Y Maeda
    The Tokyo Metropolitan Institute of Medical Science Rinshoken, Dept of Laboratory Animal Science, Japan
    Mamm Genome 12:278-83. 2001
    ..The rct locus essential for the onset of the cataract was tightly linked to D4Mit278 on Chromosome (Chr) 4 with no recombination. The mrct locus was closely linked to D5Mit239 (chi2 = 66.3, P << 0.00001) on Chr 5...
  10. ncbi Aey2, a new mutation in the betaB2-crystallin-encoding gene of the mouse
    J Graw
    Forschungszentrum für Umwelt und Gesundheit GSF Institute of Experimental Genetics, Neuherberg, Germany
    Invest Ophthalmol Vis Sci 42:1574-80. 2001
    ..One particular mutant was found that caused progressive opacity and was referred to as Aey2. The purpose of the study was to provide a morphologic description, to map the mutant gene, and to characterize the underlying molecular lesion...
  11. ncbi The upstream ectoderm enhancer in Pax6 has an important role in lens induction
    P V Dimanlig
    Developmental Genetics Program, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Development 128:4415-24. 2001
    ..This pathway forms a basis for future analysis of lens induction mechanism...
  12. ncbi Hermansky-Pudlak syndrome is caused by mutations in HPS4, the human homolog of the mouse light-ear gene
    Tamio Suzuki
    Human Medical Genetics Program, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Nat Genet 30:321-4. 2002
    ..In addition, the HPS1 protein is absent in tissues of le mutant mice. These results suggest that the HPS4 and HPS1 proteins may function in the same pathway of organelle biogenesis...
  13. ncbi Unique contribution of heat shock transcription factor 4 in ocular lens development and fiber cell differentiation
    Jin Na Min
    Institute of Molecular Medicine and Genetics, Department of Radiology, Medical College of Georgia, Augusta, Georgia 30912 3175, USA
    Genesis 40:205-17. 2004
    ..Thus, HSF4 fulfills a central role in controlling spatial and temporal expression of genes critical for correct development and function of the lens...
  14. pmc Rybp, a polycomb complex-associated protein, is required for mouse eye development
    Melinda K Pirity
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    BMC Dev Biol 7:39. 2007
    ..Here we investigated the requirement for Rybp in ocular development using four in vivo mouse models which resulted in either the ablation or overexpression of Rybp...