Crygb

Summary

Gene Symbol: Crygb
Description: crystallin, gamma B
Alias: Cryg-3, DGcry-3, Nop, gamma-crystallin B, gamma-B-crystallin, gamma-crystallin 3, gammaB-crystallin, nuclear opacity
Species: mouse
Products:     Crygb

Top Publications

  1. Graw J, Neuhäuser Klaus A, Klopp N, Selby P, Löster J, Favor J. Genetic and allelic heterogeneity of Cryg mutations in eight distinct forms of dominant cataract in the mouse. Invest Ophthalmol Vis Sci. 2004;45:1202-13 pubmed
    ..and subcortical opacity (Crygd(K10), Crygc(MNU8), Cryge(Z2), Crygd(ENU4011), and Cryge(ADD15306)), to dense nuclear opacity and ruptured lenses (Cryga(ENU469))...
  2. Li L, Chang B, Cheng C, Chang D, Hawes N, Xia C, et al. Dense nuclear cataract caused by the gammaB-crystallin S11R point mutation. Invest Ophthalmol Vis Sci. 2008;49:304-9 pubmed publisher
    ..Subsequent activation of calcium-dependent protein degradation and degeneration of inner mature fiber cells led to the dense nuclear cataract. ..
  3. Liu H, Du X, Wang M, Huang Q, Ding L, McDonald H, et al. Crystallin {gamma}B-I4F mutant protein binds to {alpha}-crystallin and affects lens transparency. J Biol Chem. 2005;280:25071-8 pubmed
    ..Thus, the lamellar cataract is likely due to the light-scattering effects of the enlarged interfiber spaces and protein aggregates caused by gammaB-I4F mutant proteins interacting with alpha-crystallin in the lens. ..
  4. Breitman M, Lok S, Wistow G, Piatigorsky J, Treton J, Gold R, et al. Gamma-crystallin family of the mouse lens: structural and evolutionary relationships. Proc Natl Acad Sci U S A. 1984;81:7762-6 pubmed
    ..The significance of these differences in terms of the structure and function of the gamma-crystallins in the mouse lens is discussed. ..
  5. Kawauchi S, Takahashi S, Nakajima O, Ogino H, Morita M, Nishizawa M, et al. Regulation of lens fiber cell differentiation by transcription factor c-Maf. J Biol Chem. 1999;274:19254-60 pubmed
    ..The expression of crystallin genes was severely impaired in the c-maf-null mutant mouse lens. These results demonstrate that c-Maf is an indispensable regulator of lens differentiation during murine development. ..
  6. Li L, Cheng C, Xia C, White T, Fletcher D, Gong X. Connexin mediated cataract prevention in mice. PLoS ONE. 2010;5: pubmed publisher
    ..Thus, the use of an array of small molecules to promote lens homeostasis may become a feasible non-surgical approach for nuclear cataract prevention in the future. ..
  7. Graw J, Kratochvilova J, Summer K. Genetical and biochemical studies of a dominant cataract mutant in mice. Exp Eye Res. 1984;39:37-45 pubmed
    A spontaneous mutation causing a nuclear opacity of the lens of the eye was detected among (101 X C3H) F1 hybrid mice. The nuclear opacity, provisional gene symbol Nop, is inherited as a single autosomal dominant gene...
  8. Woodward E, Monaco J. Characterization and mapping of the gene encoding mouse proteasome subunit DELTA (Lmp19). Immunogenetics. 1995;42:28-34 pubmed
    ....
  9. DePianto D, Blankenship T, Hess J, FitzGerald P. Analysis of non-crystallin lens fiber cell gene expression in c-Maf -/- mice. Mol Vis. 2003;9:288-94 pubmed
    ..This suggests that increases in transcription of non-crystallin lens fiber cell genes can be enacted in a c-Maf independent fashion. ..
  10. Kim S, Cheong C, Sohn Y, Goo Y, Oh W, Park J, et al. Multiple developmental defects derived from impaired recruitment of ASC-2 to nuclear receptors in mice: implication for posterior lenticonus with cataract. Mol Cell Biol. 2002;22:8409-14 pubmed
    ..Our results provide a novel insight into the molecular and histopathological mechanism of posterior lenticonus with cataract and attest to the importance of ASC-2 as a pivotal transcriptional coactivator of nuclear receptors in vivo...

Scientific Experts

Detail Information

Publications32

  1. Graw J, Neuhäuser Klaus A, Klopp N, Selby P, Löster J, Favor J. Genetic and allelic heterogeneity of Cryg mutations in eight distinct forms of dominant cataract in the mouse. Invest Ophthalmol Vis Sci. 2004;45:1202-13 pubmed
    ..and subcortical opacity (Crygd(K10), Crygc(MNU8), Cryge(Z2), Crygd(ENU4011), and Cryge(ADD15306)), to dense nuclear opacity and ruptured lenses (Cryga(ENU469))...
  2. Li L, Chang B, Cheng C, Chang D, Hawes N, Xia C, et al. Dense nuclear cataract caused by the gammaB-crystallin S11R point mutation. Invest Ophthalmol Vis Sci. 2008;49:304-9 pubmed publisher
    ..Subsequent activation of calcium-dependent protein degradation and degeneration of inner mature fiber cells led to the dense nuclear cataract. ..
  3. Liu H, Du X, Wang M, Huang Q, Ding L, McDonald H, et al. Crystallin {gamma}B-I4F mutant protein binds to {alpha}-crystallin and affects lens transparency. J Biol Chem. 2005;280:25071-8 pubmed
    ..Thus, the lamellar cataract is likely due to the light-scattering effects of the enlarged interfiber spaces and protein aggregates caused by gammaB-I4F mutant proteins interacting with alpha-crystallin in the lens. ..
  4. Breitman M, Lok S, Wistow G, Piatigorsky J, Treton J, Gold R, et al. Gamma-crystallin family of the mouse lens: structural and evolutionary relationships. Proc Natl Acad Sci U S A. 1984;81:7762-6 pubmed
    ..The significance of these differences in terms of the structure and function of the gamma-crystallins in the mouse lens is discussed. ..
  5. Kawauchi S, Takahashi S, Nakajima O, Ogino H, Morita M, Nishizawa M, et al. Regulation of lens fiber cell differentiation by transcription factor c-Maf. J Biol Chem. 1999;274:19254-60 pubmed
    ..The expression of crystallin genes was severely impaired in the c-maf-null mutant mouse lens. These results demonstrate that c-Maf is an indispensable regulator of lens differentiation during murine development. ..
  6. Li L, Cheng C, Xia C, White T, Fletcher D, Gong X. Connexin mediated cataract prevention in mice. PLoS ONE. 2010;5: pubmed publisher
    ..Thus, the use of an array of small molecules to promote lens homeostasis may become a feasible non-surgical approach for nuclear cataract prevention in the future. ..
  7. Graw J, Kratochvilova J, Summer K. Genetical and biochemical studies of a dominant cataract mutant in mice. Exp Eye Res. 1984;39:37-45 pubmed
    A spontaneous mutation causing a nuclear opacity of the lens of the eye was detected among (101 X C3H) F1 hybrid mice. The nuclear opacity, provisional gene symbol Nop, is inherited as a single autosomal dominant gene...
  8. Woodward E, Monaco J. Characterization and mapping of the gene encoding mouse proteasome subunit DELTA (Lmp19). Immunogenetics. 1995;42:28-34 pubmed
    ....
  9. DePianto D, Blankenship T, Hess J, FitzGerald P. Analysis of non-crystallin lens fiber cell gene expression in c-Maf -/- mice. Mol Vis. 2003;9:288-94 pubmed
    ..This suggests that increases in transcription of non-crystallin lens fiber cell genes can be enacted in a c-Maf independent fashion. ..
  10. Kim S, Cheong C, Sohn Y, Goo Y, Oh W, Park J, et al. Multiple developmental defects derived from impaired recruitment of ASC-2 to nuclear receptors in mice: implication for posterior lenticonus with cataract. Mol Cell Biol. 2002;22:8409-14 pubmed
    ..Our results provide a novel insight into the molecular and histopathological mechanism of posterior lenticonus with cataract and attest to the importance of ASC-2 as a pivotal transcriptional coactivator of nuclear receptors in vivo...
  11. Xie Q, Cvekl A. The orchestration of mammalian tissue morphogenesis through a series of coherent feed-forward loops. J Biol Chem. 2011;286:43259-71 pubmed publisher
    ....
  12. Yoshimoto A, Saigou Y, Higashi Y, Kondoh H. Regulation of ocular lens development by Smad-interacting protein 1 involving Foxe3 activation. Development. 2005;132:4437-48 pubmed
    ..26 kb promoter, and are separate from lens-specific regulation. This is the first demonstration of the significance of Smad interaction in modulating Sip1 activity. ..
  13. Min J, Zhang Y, Moskophidis D, Mivechi N. Unique contribution of heat shock transcription factor 4 in ocular lens development and fiber cell differentiation. Genesis. 2004;40:205-17 pubmed
    ..Thus, HSF4 fulfills a central role in controlling spatial and temporal expression of genes critical for correct development and function of the lens. ..
  14. Fujimoto M, Izu H, Seki K, Fukuda K, Nishida T, Yamada S, et al. HSF4 is required for normal cell growth and differentiation during mouse lens development. EMBO J. 2004;23:4297-306 pubmed
    ....
  15. Murer Orlando M, Paterson R, Lok S, Tsui L, Breitman M. Differential regulation of gamma-crystallin genes during mouse lens development. Dev Biol. 1987;119:260-7 pubmed
    ..This complex pattern of gene regulation presumably accounts for one of the mechanisms determining the spatial distribution of different gamma-crystallins within the lens. ..
  16. Nishiguchi S, Wood H, Kondoh H, Lovell Badge R, Episkopou V. Sox1 directly regulates the gamma-crystallin genes and is essential for lens development in mice. Genes Dev. 1998;12:776-81 pubmed
    ..It appears that the direct interaction of the SOX1 protein with a promoter element conserved in all gamma-crystallin genes is responsible for their expression. ..
  17. Leiter E, Tsumura H, Serreze D, Chapman H, Rabin D, Lan M, et al. Mapping to chromosomes 1 and 12 of mouse homologs of human protein tyrosine phosphatase, receptor-type, related genes encoding pancreatic beta cell autoantigens. Mamm Genome. 1997;8:949-50 pubmed
  18. Santhiya S, Abd alla S, Loster J, Graw J. Reduced levels of gamma-crystallin transcripts during embryonic development of murine Cat2nop mutant lenses. Graefes Arch Clin Exp Ophthalmol. 1995;233:795-800 pubmed
    ..This result represents an additional line of argument that the gamma-crystallin genes may be the target of the mutation in the Cat2 mice. ..
  19. Klopp N, Favor J, Loster J, Lutz R, Neuhauser Klaus A, Prescott A, et al. Three murine cataract mutants (Cat2) are defective in different gamma-crystallin genes. Genomics. 1998;52:152-8 pubmed
    ..The mutant allele Crygbnop (formerly Cat2(nop)) is caused by a replacement of 11 bp by 4 bp in the third exon of Crygb, while a C-->G transversion in exon 3 of Cryge has been found for the Cryget (formerly Cat2(t)) mutation...
  20. Quinlan P, Oda S, Breitman M, Tsui L. The mouse eye lens obsolescence (Elo) mutant: studies on crystallin gene expression and linkage analysis between the mutant locus and the gamma-crystallin genes. Genes Dev. 1987;1:637-44 pubmed
    ..4 +/- 0.9 cM, whereas that between gamma 6 and the distantly linked gamma 2 gene is 2.7 +/- 1.3 cM. Our data also suggest the possibility of recombination hot spots with the gamma-crystallin gene cluster. ..
  21. Shinohara T, Robinson E, Appella E, Piatigorsky J. Multiple gamma-crystallins of the mouse lens: fractionation of mRNAs by cDNA cloning. Proc Natl Acad Sci U S A. 1982;79:2783-7 pubmed
    ..These data indicate that there are at least four similar gamma-crystallin mRNAs and suggest (but do not establish) the existence of a closely related family of gamma-crystallin genes. ..
  22. Graw J, Liebstein A, Pietrowski D, Schmitt John T, Werner T. Genomic sequences of murine gamma B- and gamma C-crystallin-encoding genes: promoter analysis and complete evolutionary pattern of mouse, rat and human gamma-crystallins. Gene. 1993;136:145-56 pubmed
    ....
  23. Jankowski S, Gumucio D. Genes for tensin, villin and desmin are linked on mouse chromosome 1. Mamm Genome. 1995;6:744-5 pubmed
  24. Sandilands A, Hutcheson A, Long H, Prescott A, Vrensen G, Löster J, et al. Altered aggregation properties of mutant gamma-crystallins cause inherited cataract. EMBO J. 2002;21:6005-14 pubmed
    ..The mutant gamma-crystallins initially disrupt nuclear function, but then this progresses to a full cataract phenotype. ..
  25. Gonzalez M, Ruggiero F, Chang Q, Shi Y, Rich M, Kraner S, et al. Disruption of Trkb-mediated signaling induces disassembly of postsynaptic receptor clusters at neuromuscular junctions. Neuron. 1999;24:567-83 pubmed
    ..These results demonstrate a novel role for neurotrophin signaling through TrkB receptors on muscle fibers in the ongoing maintenance of postsynaptic AChR regions. ..
  26. Sagane K, Yamazaki K, Mizui Y, Tanaka I. Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23. Gene. 1999;236:79-86 pubmed
    ..The structures of these ADAM proteins strongly suggest that they could function as integrin receptors. The implications of the cellular disintegrins in neural development are discussed. ..
  27. Wigle J, Chowdhury K, Gruss P, Oliver G. Prox1 function is crucial for mouse lens-fibre elongation. Nat Genet. 1999;21:318-22 pubmed
    ..Our data provide evidence that the progression of terminal fibre differentiation and elongation is dependent on Prox1 activity during lens development. ..
  28. Varfolomeev E, Schuchmann M, Luria V, Chiannilkulchai N, Beckmann J, Mett I, et al. Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally. Immunity. 1998;9:267-76 pubmed
    ..These findings indicate that Caspase 8 plays a necessary and nonredundant role in death induction by several receptors of the TNF/NGF family and serves a vital role in embryonal development. ..
  29. Liu Y, Zacksenhaus E. E2F1 mediates ectopic proliferation and stage-specific p53-dependent apoptosis but not aberrant differentiation in the ocular lens of Rb deficient fetuses. Oncogene. 2000;19:6065-73 pubmed
    ..Thus, inactivation of E2F1 reduces ectopic cell proliferation and stage-specific p53-dependent apoptosis but does not rescue the differentiation defects associated with loss of Rb during lens development. ..
  30. Goring D, Breitman M, Tsui L. Temporal regulation of six crystallin transcripts during mouse lens development. Exp Eye Res. 1992;54:785-95 pubmed
    ..The utility of the PCR technique in studying the relative abundance of steady-state gamma-crystallin mRNAs was also investigated. ..
  31. Cheng C, Xia C, Huang Q, Ding L, Horwitz J, Gong X. Altered chaperone-like activity of alpha-crystallins promotes cataractogenesis. J Biol Chem. 2010;285:41187-93 pubmed publisher
    ..Crystallins with different chaperone-like activities are likely required in the lens cortex and nucleus for maintaining transparency. ..
  32. Kratochvilova J, Favor J. Allelism tests of 15 dominant cataract mutations in mice. Genet Res. 1992;59:199-203 pubmed
    ..The biomicroscopic examination of the eyes showed that phenotypically similar as well as very distinct cataract mutations can be alleles of the same gene. Conversely, phenotypically similar mutations were shown to be non-allelic. ..