Ctcf

Summary

Gene Symbol: Ctcf
Description: CCCTC-binding factor
Alias: AW108038, transcriptional repressor CTCF, 11-zinc finger protein, CTCFL paralog
Species: mouse

Top Publications

  1. pmc The nucleotides responsible for the direct physical contact between the chromatin insulator protein CTCF and the H19 imprinting control region manifest parent of origin-specific long-distance insulation and methylation-free domains
    Vinod Pant
    Department of Development and Genetics, Evolution Biology Centre, Uppsala University, S 752 36 Uppsala, Sweden
    Genes Dev 17:586-90. 2003
  2. ncbi Effect of CTCF-binding motif on regulation of PAX6 transcription
    Dan Wu
    Health Science Center, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, People s Republic of China
    Invest Ophthalmol Vis Sci 47:2422-9. 2006
  3. pmc The testis-specific factor CTCFL cooperates with the protein methyltransferase PRMT7 in H19 imprinting control region methylation
    Petar Jelinic
    Institute of Pathology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    PLoS Biol 4:e355. 2006
  4. ncbi Identification of a Ctcf cofactor, Yy1, for the X chromosome binary switch
    Mary E Donohoe
    Howard Hughes Medical Institute, USA
    Mol Cell 25:43-56. 2007
  5. ncbi CTCF regulates asynchronous replication of the imprinted H19/Igf2 domain
    Rosita Bergstrom
    Department of Development and Genetics, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden
    Cell Cycle 6:450-4. 2007
  6. doi Cohesins functionally associate with CTCF on mammalian chromosome arms
    Vania Parelho
    Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK
    Cell 132:422-33. 2008
  7. pmc CTCF binding and higher order chromatin structure of the H19 locus are maintained in mitotic chromatin
    Les J Burke
    Institute for Genetics, Justus Liebig Universitaet Giessen, Giessen, Germany
    EMBO J 24:3291-300. 2005
  8. ncbi CTCF mediates interchromosomal colocalization between Igf2/H19 and Wsb1/Nf1
    Jian Qun Ling
    Medical Service, Department of Veterans Affairs, Palo Alto Health Care System, and Department of Medicine, Stanford University, Palo Alto, CA 94304, USA
    Science 312:269-72. 2006
  9. pmc CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2
    Sreenivasulu Kurukuti
    Department of Development and Genetics, Uppsala University, Norbyvagen 18A, S 752 36 Uppsala, Sweden
    Proc Natl Acad Sci U S A 103:10684-9. 2006
  10. ncbi CTCF-dependent chromatin insulator is linked to epigenetic remodeling
    Ko Ishihara
    Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Mol Cell 23:733-42. 2006

Research Grants

Scientific Experts

  • PIROSKA E SZABO
  • CHRISTOPHER KEMP
  • Niels Galjart
  • Galina N Filippova
  • L J Burke
  • C Kanduri
  • Pierre Antoine Defossez
  • Frank Grosveld
  • Rolf Ohlsson
  • Helen Heath
  • Jeannie T Lee
  • Tiziana Guastafierro
  • Claudia Ribeiro de Almeida
  • Marisa S Bartolomei
  • Mary E Donohoe
  • Michele Zampieri
  • Stephanie C Degner
  • Melissa J MacPherson
  • Suzanne van de Nobelen
  • Victor Lobanenkov
  • Na Xu
  • Vinod Pant
  • Andre J Faure
  • Boris Lenhard
  • Ralph Stadhouders
  • Kristin D Kernohan
  • Rainer Renkawitz
  • Anna Reale
  • Sreenivasulu Kurukuti
  • Paola Caiafa
  • Ann J Feeney
  • Luo Lu
  • Victor V Lobanenkov
  • Dong Hoon Lee
  • Rudi W Hendriks
  • Erik Splinter
  • Frank Sleutels
  • Ko Ishihara
  • Dmitri I Loukinov
  • Ziedulla Abdullaev
  • Rebecca J Spencer
  • Nora Engel
  • Richard M Schultz
  • Nam Kyung Yu
  • Tao Li
  • Emma Monte
  • Elena Klenova
  • Elzo de Wit
  • Paul Childress
  • Tae Gyun Kim
  • Y Fang
  • S Tsui
  • James W Austin
  • L Ashley Watson
  • Elena M Pugacheva
  • Christopher J Schoenherr
  • Fangyu Shi
  • Sha Sun
  • Lylia Ouboussad
  • Manuel Rosa-Garrido
  • Gary Felsenfeld
  • Ling Wang
  • Vlad C Seitan
  • Paul Flicek
  • Vijay Kumar Tiwari
  • Fabio Ciccarone
  • Roberta Calabrese
  • KEVIN MONAHAN
  • Chen Feng Qi
  • George A Follows
  • Monica K Ertel
  • Anandi Bhattacharya
  • Marcella Macaluso
  • Hannah C Stevens
  • Brian C Del Rosario
  • Nathalie G Berube
  • Han Yu Shih
  • Supat Thongjuea
  • Wilfred van Ijcken
  • Eric Soler
  • Jiyoti Verma-Gaur
  • Ali Torkamani
  • Jie Gao
  • Claudia Bossen
  • Chunguang Guo
  • Shu Lin
  • Bryce L Sopher
  • Paul Delgado-Olguín
  • Folami Y Ideraabdullah
  • Elena Pugacheva

Detail Information

Publications93

  1. pmc The nucleotides responsible for the direct physical contact between the chromatin insulator protein CTCF and the H19 imprinting control region manifest parent of origin-specific long-distance insulation and methylation-free domains
    Vinod Pant
    Department of Development and Genetics, Evolution Biology Centre, Uppsala University, S 752 36 Uppsala, Sweden
    Genes Dev 17:586-90. 2003
    ..Igf2 allele has been proposed to depend on a methylation-sensitive chromatin insulator organized by the 11 zinc finger protein CTCF at the H19 imprinting control region (ICR)...
  2. ncbi Effect of CTCF-binding motif on regulation of PAX6 transcription
    Dan Wu
    Health Science Center, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, People s Republic of China
    Invest Ophthalmol Vis Sci 47:2422-9. 2006
    Previous studies indicate that the CCCTC binding transcription factor (CTCF) regulates homeobox PAX6 gene transcription in corneal epithelial cells...
  3. pmc The testis-specific factor CTCFL cooperates with the protein methyltransferase PRMT7 in H19 imprinting control region methylation
    Petar Jelinic
    Institute of Pathology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    PLoS Biol 4:e355. 2006
    ..We demonstrate that CTCFL/BORIS, a paralog of CTCF, is an ICR-binding protein expressed during embryonic male germ cell development, coinciding with the timing of ICR ..
  4. ncbi Identification of a Ctcf cofactor, Yy1, for the X chromosome binary switch
    Mary E Donohoe
    Howard Hughes Medical Institute, USA
    Mol Cell 25:43-56. 2007
    ..Although no proven trans-acting factors have been identified, a likely candidate is Ctcf, a chromatin insulator with essential function in autosomal imprinting...
  5. ncbi CTCF regulates asynchronous replication of the imprinted H19/Igf2 domain
    Rosita Bergstrom
    Department of Development and Genetics, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden
    Cell Cycle 6:450-4. 2007
    ..At the imprinted H19/Igf2 domain, the methylated paternal allele replicates early while the CTCF-bound maternal allele replicates late during S phase...
  6. doi Cohesins functionally associate with CTCF on mammalian chromosome arms
    Vania Parelho
    Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK
    Cell 132:422-33. 2008
    ..occupy a subset of DNase I hypersensitive sites, many of which contain sequence motifs resembling the consensus for CTCF, a DNA-binding protein with enhancer blocking function and boundary-element activity...
  7. pmc CTCF binding and higher order chromatin structure of the H19 locus are maintained in mitotic chromatin
    Les J Burke
    Institute for Genetics, Justus Liebig Universitaet Giessen, Giessen, Germany
    EMBO J 24:3291-300. 2005
    ..For the zinc-finger protein CTCF, a role in interpreting and propagating epigenetic states and in separating expression domains has been documented...
  8. ncbi CTCF mediates interchromosomal colocalization between Igf2/H19 and Wsb1/Nf1
    Jian Qun Ling
    Medical Service, Department of Veterans Affairs, Palo Alto Health Care System, and Department of Medicine, Stanford University, Palo Alto, CA 94304, USA
    Science 312:269-72. 2006
    ..Omission of CCCTC-binding factor (CTCF) or deletion of the maternal ICR abrogated this association and altered Wsb1/Nf1 gene expression...
  9. pmc CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2
    Sreenivasulu Kurukuti
    Department of Development and Genetics, Uppsala University, Norbyvagen 18A, S 752 36 Uppsala, Sweden
    Proc Natl Acad Sci U S A 103:10684-9. 2006
    ..the H19 imprinting control region (ICR) directs the silencing of the maternally inherited Igf2 allele through a CTCF-dependent chromatin insulator...
  10. ncbi CTCF-dependent chromatin insulator is linked to epigenetic remodeling
    Ko Ishihara
    Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Mol Cell 23:733-42. 2006
    ..Here, we show that the SNF2-like chromodomain helicase protein CHD8 interacts with the insulator binding protein CTCF. Chromatin immunoprecipitation analysis revealed that CHD8 was present at known CTCF target sites, such as the ..
  11. ncbi Evidence that homologous X-chromosome pairing requires transcription and Ctcf protein
    Na Xu
    Howard Hughes Medical Institute Department of Molecular Biology, Massachusetts General Hospital Department of Genetics, Harvard Medical School Boston, Massachusetts 02114, USA
    Nat Genet 39:1390-6. 2007
    ..However, a common denominator among them is the presence of the protein Ctcf, a chromatin insulator that we find to be essential for pairing...
  12. pmc CTCF is the master organizer of domain-wide allele-specific chromatin at the H19/Igf2 imprinted region
    Li Han
    Division of Molecular Biology, Beckman Research Institute of the City of Hope, 1450 East Duarte Rd, Duarte, CA 91010 3011, USA
    Mol Cell Biol 28:1124-35. 2008
    ..b>CTCF protein binding in the ICR is required in the maternal chromosome for insulating Igf2 from the shared enhancers, ..
  13. pmc Transcriptional repression by the insulator protein CTCF involves histone deacetylases
    M Lutz
    Genetisches Institut der Justus Liebig Universitat, Heinrich Buff Ring 58 62, 35392 Giessen, Germany
    Nucleic Acids Res 28:1707-13. 2000
    The highly conserved zinc-finger protein, CTCF, is a candidate tumor suppressor protein that binds to highly divergent DNA sequences...
  14. pmc CCCTC-binding factor activates PARP-1 affecting DNA methylation machinery
    Tiziana Guastafierro
    Department of Cellular Biotechnology and Haematology, University La Sapienza, Piazzale Aldo Moro 5, 00161 Rome, Italy
    J Biol Chem 283:21873-80. 2008
    ..Here we show that transient ectopic overexpression of CCCTC-binding factor (CTCF) induces PAR accumulation, PARP-1, and CTCF poly(ADP-ribosyl)ation in the same mouse fibroblasts...
  15. pmc Maternal depletion of CTCF reveals multiple functions during oocyte and preimplantation embryo development
    Le Ben Wan
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Development 135:2729-38. 2008
    b>CTCF is a multifunctional nuclear factor involved in epigenetic regulation...
  16. pmc CTCF regulates allelic expression of Igf2 by orchestrating a promoter-polycomb repressive complex 2 intrachromosomal loop
    Tao Li
    Medical Service, VA Palo Alto Health Care System, Palo Alto, California 94304, USA
    Mol Cell Biol 28:6473-82. 2008
    b>CTCF is a zinc finger DNA-binding protein that regulates the epigenetic states of numerous target genes...
  17. pmc CTCF regulates cell cycle progression of alphabeta T cells in the thymus
    Helen Heath
    Department of Cell Biology and Genetics, Erasmus MC, Rotterdam, The Netherlands
    EMBO J 27:2839-50. 2008
    The 11-zinc finger protein CCCTC-binding factor (CTCF) is a highly conserved protein, involved in imprinting, long-range chromatin interactions and transcription...
  18. pmc The CTCF insulator protein is posttranslationally modified by SUMO
    Melissa J MacPherson
    Department of Molecular Genetics, 1 King s College Circle, University of Toronto, Toronto, ON, Canada
    Mol Cell Biol 29:714-25. 2009
    The CTCF protein is a highly conserved zinc finger protein that is implicated in many aspects of gene regulation and nuclear organization. Its functions include the ability to act as a repressor of genes, including the c-myc oncogene...
  19. pmc Cutting edge: developmental stage-specific recruitment of cohesin to CTCF sites throughout immunoglobulin loci during B lymphocyte development
    Stephanie C Degner
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 182:44-8. 2009
    ..5 Mb in each locus, in proximity to DJ(H) or J(kappa) genes. CCCTC-binding factor (CTCF) is a transcription factor that regulates gene expression by long-range chromosomal looping...
  20. pmc CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells
    Stephanie C Degner
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 108:9566-71. 2011
    ..Because CCCTC-binding factor (CTCF) has been demonstrated to be involved in long-range chromosomal interactions, we hypothesized that CTCF may promote ..
  21. pmc The CTCF insulator protein forms an unusual DNA structure
    Melissa J MacPherson
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    BMC Mol Biol 11:101. 2010
    The CTCF insulator protein is a highly conserved zinc finger protein that has been implicated in many aspects of gene regulation and nuclear organization. The protein has been hypothesized to organize the human genome by forming DNA loops.
  22. ncbi Transgenic RNAi reveals essential function for CTCF in H19 gene imprinting
    Andrew M Fedoriw
    Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 303:238-40. 2004
    ..Insulin-like growth factor 2 expression involves binding of the vertebrate insulator protein, CCCTC binding factor (CTCF), to the maternally hypomethylated differentially methylated domain (DMD)...
  23. ncbi CTCF, a candidate trans-acting factor for X-inactivation choice
    Wendy Chao
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Department of Genetics, Harvard Medical School, Boston, MA 02114, USA
    Science 295:345-7. 2002
    ..Here, we identify the insulator and transcription factor, CTCF, as a candidate trans-acting factor for X-chromosome selection...
  24. pmc Mutation of a single CTCF target site within the H19 imprinting control region leads to loss of Igf2 imprinting and complex patterns of de novo methylation upon maternal inheritance
    Vinod Pant
    Department of Development and Genetics, Evolution Biology Centre, Uppsala University, S 752 36 Uppsala, Sweden
    Mol Cell Biol 24:3497-504. 2004
    ..shown that maternal inheritance of mutated (three of the four) target sites for the 11-zinc finger protein CTCF leads to loss of Igf2 imprinting...
  25. ncbi CTCF maintains differential methylation at the Igf2/H19 locus
    Christopher J Schoenherr
    Department of Cell and Structural Biology, University of Illinois, Urbana Champaign, Urbana, Illinois 61801, USA
    Nat Genet 33:66-9. 2003
    ..One candidate regulator of methylation, the zinc-finger protein CTCF, binds to the imprinting control region (ICR) of the genes Igf2 (encoding insulin-like growth factor 2) and H19 (..
  26. ncbi Poly(ADP-ribosyl)ation regulates CTCF-dependent chromatin insulation
    Wenqiang Yu
    Department of Development and Genetics, Evolution Biology Centre, Uppsala University, Norbyvagen 18A, S 752 36 Uppsala, Sweden
    Nat Genet 36:1105-10. 2004
    ..We show that the chromatin insulator protein CTCF carries a post-translational modification: poly(ADP-ribosyl)ation...
  27. pmc BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma
    Dmitri I Loukinov
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0760, USA
    Proc Natl Acad Sci U S A 99:6806-11. 2002
    b>CTCF, a conserved, ubiquitous, and highly versatile 11-zinc-finger factor involved in various aspects of gene regulation, forms methylation-sensitive insulators that regulate X chromosome inactivation and expression of imprinted genes...
  28. pmc An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes
    G N Filippova
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Mol Cell Biol 16:2802-13. 1996
    We have isolated and analyzed human CTCF cDNA clones and show here that the ubiquitously expressed 11-zinc-finger factor CTCF is an exceptionally highly conserved protein displaying 93% identity between avian and human amino acid ..
  29. pmc Role of CTCF binding sites in the Igf2/H19 imprinting control region
    PIROSKA E SZABO
    Division of Biology, Beckman Research Institute of the City of Hope, 1450 East Duarte Rd, Duarte, CA 91010 3011, USA
    Mol Cell Biol 24:4791-800. 2004
    ..In somatic cells, the hypomethylated maternally inherited ICR binds the insulator protein CTCF at four sites and blocks activity of the proximal Igf2 promoter by insulating it from its distal enhancers...
  30. pmc CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus
    Erik Splinter
    Department of Cell Biology and Genetics, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
    Genes Dev 20:2349-54. 2006
    b>CTCF (CCCTC-binding factor) binds sites around the mouse beta-globin locus that spatially cluster in the erythroid cell nucleus...
  31. ncbi Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development
    Galina N Filippova
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Dev Cell 8:31-42. 2005
    ..We report that the 5' end of Jarid1c, a mouse escape gene adjacent to an inactivated gene, binds CTCF, displays high levels of histone H3 acetylation, and functions as a CTCF-dependent chromatin insulator...
  32. pmc A transducible nuclear/nucleolar protein, mLLP, regulates neuronal morphogenesis and synaptic transmission
    Nam Kyung Yu
    Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, South Korea
    Sci Rep 6:22892. 2016
    ..Moreover, mLLP interacts with CCCTC-binding factor (CTCF) as well as transcriptional machineries and modulates gene expression involved in neuronal growth...
  33. pmc The expression of Pax6 variants is subject to posttranscriptional regulation in the developing mouse eyelid
    Fangyu Shi
    State Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China
    PLoS ONE 8:e53919. 2013
    ..This study offers insight into the function of the Pax6 protein in eyelid development...
  34. doi ADP-ribose polymer depletion leads to nuclear Ctcf re-localization and chromatin rearrangement(1)
    Tiziana Guastafierro
    Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Section of Histology and Embryology, Faculty of Pharmacy and Medicine, Sapienza University Rome, V le Regina Elena 324, 00161 Rome, Italy
    Biochem J 449:623-30. 2013
    b>Ctcf (CCCTC-binding factor) directly induces Parp [poly(ADP-ribose) polymerase] 1 activity and its PARylation [poly(ADPribosyl)ation] in the absence of DNA damage...
  35. pmc Mapping and functional characterisation of a CTCF-dependent insulator element at the 3' border of the murine Scl transcriptional domain
    George A Follows
    Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 7:e31484. 2012
    ..at the boundary of active and inactive chromatin, does not function as a classical tissue-specific enhancer, binds CTCF and is both necessary and sufficient for insulator function in haematopoietic cells in vitro...
  36. pmc Reciprocal Regulation of the Cardiac Epigenome by Chromatin Structural Proteins Hmgb and Ctcf: IMPLICATIONS FOR TRANSCRIPTIONAL REGULATION
    Emma Monte
    From the Departments of Anesthesiology
    J Biol Chem 291:15428-46. 2016
    ..We examined the roles of two chromatin structural proteins, Ctcf (CCCTC-binding factor) and Hmgb2 (high mobility group protein B2), in regulating pathologic transcription and ..
  37. pmc CTCF regulates the local epigenetic state of ribosomal DNA repeats
    Suzanne van de Nobelen
    Department of Cell Biology and Genetics, Erasmus MC, The Netherlands
    Epigenetics Chromatin 3:19. 2010
    CCCTC binding factor (CTCF) is a highly conserved zinc finger protein, which is involved in chromatin organization, local histone modifications, and RNA polymerase II-mediated gene transcription...
  38. doi CTCF Binding Polarity Determines Chromatin Looping
    Elzo de Wit
    Hubrecht Institute KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Mol Cell 60:676-84. 2015
    CCCTC-binding factor (CTCF) is an architectural protein involved in the three-dimensional (3D) organization of chromatin...
  39. doi CTCF-regulating endocrine function of pancreatic islet cells in transgenic mice
    Y Fang
    Shandong Blood Center, Jinan, Shandong Province, P R China
    Horm Metab Res 46:419-23. 2014
    ..studies from our lab demonstrate for the first time that Pax6 transcription is regulated by CCCTC binding factor (CTCF), a nuclear protein and transcription regulator...
  40. pmc Epidermal growth factor (EGF)-induced corneal epithelial wound healing through nuclear factor κB subtype-regulated CCCTC binding factor (CTCF) activation
    Ling Wang
    Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Torrance, California 90503, USA
    J Biol Chem 288:24363-71. 2013
    ..study aimed to understand the role of NFκB in EGF-induced corneal epithelial wound healing through regulation of CTCF activity, which plays important roles in cell motility and migration to promote wound healing...
  41. doi CTCF depletion alters chromatin structure and transcription of myeloid-specific factors
    Lylia Ouboussad
    Section of Experimental Haematology, Leeds Institute of Cancer Studies and Pathology, University of Leeds, Wellcome Trust Brenner Building, St James s University Hospital, Leeds LS9 7TF, UK
    J Mol Cell Biol 5:308-22. 2013
    ..Here, we show that the rate of differentiation of common myeloid precursor cells increases after depletion of CTCF, a protein emerging as a potential key factor regulating higher-order chromatin structure...
  42. pmc Genome-Wide Mapping and Interrogation of the Nmp4 Antianabolic Bone Axis
    Paul Childress
    Department of Anatomy and Cell Biology P C, S H B, D H, A G R, M R A, J P B, Indiana University School of Medicine, Indianapolis, Indiana 46202 Lilly Research Laboratories K R S, J K M, Z R G, V K, Eli Lilly and Company, Indianapolis, Indiana 46202 Orthopaedic Surgery M B A, Indiana University School of Medicine Department of Medical and Molecular Genetics Z W, Y S, Y L, J P B, Indiana University School of Medicine Center for Computational Biology and Bioinformatics Z W, Y L, Indiana University School of Medicine Department of Pediatrics Y H, F C Y, Indiana University School of Medicine Herman B Wells Center for Pediatric Research Y H, F C Y Cellular and Integrative Physiology F M P Center for Translational Musculoskeletal Research S J W, School of Health and Rehabilitation Sciences, Indiana University and Department of Physical Therapy S J W, School of Health and Rehabilitation Sciences, Indiana University, Indianapolis, Indiana 46202
    Mol Endocrinol 29:1269-85. 2015
    ..These data suggest that Nmp4 suppresses bone anabolism, in part, by regulating IGF-binding protein expression. Changes in Nmp4 status may lead to improvements in osteoprogenitor response to therapeutic cues. ..
  43. pmc Cohesin-based chromatin interactions enable regulated gene expression within preexisting architectural compartments
    Vlad C Seitan
    Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London, London W12 0NN, United Kingdom
    Genome Res 23:2066-77. 2013
    ..In addition, cohesin associates with active enhancers and promoters and with CTCF to form long-range interactions important for gene regulation...
  44. doi CCCTC-binding factor controls the homeostatic maintenance and migration of Langerhans cells
    Tae Gyun Kim
    Department of Environmental Medical Biology, Institute of Tropical Medicine, Yonsei University College of Medicine, Seoul, Korea Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea
    J Allergy Clin Immunol 136:713-24. 2015
    Langerhans cells (LCs) are skin-resident dendritic cells (DCs) that orchestrate skin immunity. CCCTC-binding factor (CTCF) is a highly conserved DNA-binding protein that regulates higher-order chromatin organization and is involved in ..
  45. pmc CCCTC-binding factor mediates effects of glucose on beta cell survival
    S Tsui
    Department of Medicine, David Geffen School of Medicine University of California Los Angeles, Torrance, CA, 90502, USA
    Cell Prolif 47:28-37. 2014
    ..The present study investigates novel effects of glucose- and insulin-induced CCCTC-binding factor (CTCF) activity on Pax6 gene expression as well as for subsequent effects of insulin-activated signalling pathways, on β-..
  46. doi Dual effect of CTCF loss on neuroprogenitor differentiation and survival
    L Ashley Watson
    Departments of Paediatrics and Biochemistry, The University of Western Ontario and Children s Health Research Institute, London, Ontario N6C 2V5, Canada and Medical Genetics Centre Department of Cell Biology and Genetics, Erasmus University, 3000 CA, Rotterdam, The Netherlands
    J Neurosci 34:2860-70. 2014
    ..The CCCTC-binding factor (CTCF) is a zinc finger DNA binding protein involved in higher-order chromatin organization, and mutations in the human ..
  47. pmc STAT3, STAT4, NFATc1, and CTCF regulate PD-1 through multiple novel regulatory regions in murine T cells
    James W Austin
    Department of Microbiology and Immunology and
    J Immunol 192:4876-86. 2014
    ..Together these data add multiple novel distal regulatory regions and pathways to the control of PD-1 expression and provide a molecular mechanism by which proinflammatory cytokines, such as IL-6 or IL-12, can augment PD-1 expression. ..
  48. pmc Characterization of ARF-BP1/HUWE1 interactions with CTCF, MYC, ARF and p53 in MYC-driven B cell neoplasms
    Chen Feng Qi
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA E Mails Y S K S X Z A A L K J S
    Int J Mol Sci 13:6204-19. 2012
    ..identified a multiprotein complex comprised of ARF-BP1, ARF, p53, MYC and the multifunctional DNA-binding factor, CTCF, which is involved in the transcriptional regulation of MYC, p53 and ARF...
  49. ncbi CTCF and Sp1 interact with the Murine gammaherpesvirus 68 internal repeat elements
    Hannah C Stevens
    Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, L69 3GE, UK
    Virus Genes 45:265-73. 2012
    ..This cell line model was used to investigate transcription factor occupancy (CCCTC binding factor [CTCF] and Sp1) of the two internal repeat elements in the viral genome during latency and reactivation using chromatin ..
  50. pmc Role of CCCTC binding factor (CTCF) and cohesin in the generation of single-cell diversity of protocadherin-α gene expression
    KEVIN MONAHAN
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 109:9125-30. 2012
    ..Here we show that both the insulator-binding protein CTCF and the cohesin complex subunit Rad21 bind to two highly conserved DNA sequences, the first within and the second ..
  51. doi Integrating role of T antigen, Rb2/p130, CTCF and BORIS in mediating non-canonical endoplasmic reticulum-dependent death pathways triggered by chronic ER stress in mouse medulloblastoma
    Marcella Macaluso
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA
    Cell Cycle 11:1841-50. 2012
    ..The diversity of these responses may be due, at least in part, to distinct activities of Rb2/p130, CTCF and BORIS proteins in response to an altered network of signaling evoked by the T-Ag presence...
  52. pmc Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules
    Andre J Faure
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom
    Genome Res 22:2163-75. 2012
    The cohesin protein complex contributes to transcriptional regulation in a CTCF-independent manner by colocalizing with master regulators at tissue-specific loci...
  53. pmc Dynamic long-range chromatin interactions control Myb proto-oncogene transcription during erythroid development
    Ralph Stadhouders
    Department of Cell Biology, Erasmus MC, Rotterdam, The Netherlands
    EMBO J 31:986-99. 2012
    ..to harbour the transition site from transcription initiation to elongation, which takes place around a conserved CTCF site. Upon erythroid differentiation, Myb expression is downregulated and the ACH destabilized...
  54. doi The DNA-binding protein CTCF limits proximal Vκ recombination and restricts κ enhancer interactions to the immunoglobulin κ light chain locus
    Claudia Ribeiro de Almeida
    Department of Pulmonary Medicine, Erasmus MC Rotterdam, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Immunity 35:501-13. 2011
    ..Here, we studied the in vivo function of the DNA-binding zinc-finger protein CTCF, which regulates interactions between enhancers and promoters...
  55. pmc ADP-ribose polymers localized on Ctcf-Parp1-Dnmt1 complex prevent methylation of Ctcf target sites
    Michele Zampieri
    Department of Cellular Biotechnologies and Hematology, Faculty of Pharmacy and Medicine, Sapienza University of Rome, V le Regina Elena 324, 00161 Rome, Italy
    Biochem J 441:645-52. 2012
    ..Our previous findings indicated that Ctcf (CCCTC-binding factor) may be an important player in key events whereby PARylation controls the unmethylated status ..
  56. pmc CTCF occupation of the herpes simplex virus 1 genome is disrupted at early times postreactivation in a transcription-dependent manner
    Monica K Ertel
    Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    J Virol 86:12741-59. 2012
    In herpes simplex virus 1 (HSV-1), binding clusters enriched in CTCF during latency have been previously identified. We hypothesized that CTCF binding to CTCF clusters in HSV-1 would be disrupted in a reactivation event...
  57. pmc Tcra gene recombination is supported by a Tcra enhancer- and CTCF-dependent chromatin hub
    Han Yu Shih
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 109:E3493-502. 2012
    ..We found that the CCCTC-binding factor (CTCF) binds to E(α) and to many locus promoters, biases E(α) to interact with these promoters, and is required for ..
  58. pmc Jpx RNA activates Xist by evicting CTCF
    Sha Sun
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02114, USA
    Cell 153:1537-51. 2013
    ..In pre-XCI cells, CTCF protein represses Xist transcription...
  59. pmc Upstream distal regulatory elements contact the Lmo2 promoter in mouse erythroid cells
    Anandi Bhattacharya
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 7:e52880. 2012
    ..Binding of CTCF and cohesin which support chromatin loops at other loci were also found within the dCR and at the Lmo2 proximal ..
  60. ncbi Critical role for the transcription regulator CCCTC-binding factor in the control of Th2 cytokine expression
    Claudia Ribeiro de Almeida
    Department of Immunology, Erasmus MC, Rotterdam, The Netherlands
    J Immunol 182:999-1010. 2009
    ..this report, we investigated the role in Th2 differentiation of the transcription regulator CCCTC-binding factor (CTCF). Chromatin immunoprecipitation analysis revealed multiple CTCF binding sites in the Th2 cytokine locus...
  61. ncbi Molecular cloning and expression of the chromatin insulator protein CTCF in Xenopus laevis
    Les J Burke
    Institute for Genetics, Justus Liebig Universitat Giessen, Heinrich Buff Ring 58 62, D 35392, Germany
    Mech Dev 113:95-8. 2002
    The zinc finger protein CTCF has been shown to mediate multiple functions connected to gene repression. Transcriptional inhibition as well as enhancer blocking and chromatin insulation are documented for CTCF in men, mice and chickens...
  62. pmc Allele-specific binding of CTCF to the multipartite imprinting control region KvDMR1
    Galina V Fitzpatrick
    Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Mol Cell Biol 27:2636-47. 2007
    ..we demonstrate by electrophoretic mobility shift assays and chromatin immunoprecipitation the existence of two CTCF binding sites within KvDMR1 that are occupied in vivo only on the unmethylated paternally derived allele...
  63. pmc Tsix-mediated epigenetic switch of a CTCF-flanked region of the Xist promoter determines the Xist transcription program
    Pablo Navarro
    Unité de Génétique Moléculaire Murine, Institut Pasteur 75724, Paris Cedex 15, France
    Genes Dev 20:2787-92. 2006
    ..We show here that a precisely defined Xist promoter region flanked by CTCF is maintained by Tsix in a heterochromatic-like state in undifferentiated embryonic stem (ES) cells and shifts to a ..
  64. pmc A chromatin insulator-like element in the herpes simplex virus type 1 latency-associated transcript region binds CCCTC-binding factor and displays enhancer-blocking and silencing activities
    Antonio L Amelio
    Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, 32610 0266, USA
    J Virol 80:2358-68. 2006
    ..revealed that (i) the long and short repeats and the unique-short region of the HSV-1 genome contain clustered CTCF (CCCTC-binding factor) motifs, (ii) CTCF motif clusters similar to those in HSV-1 are conserved in other ..
  65. pmc Rasgrf1 imprinting is regulated by a CTCF-dependent methylation-sensitive enhancer blocker
    Bongjune Yoon
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Mol Cell Biol 25:11184-90. 2005
    ..Here we identify the mechanism by which methylation controls imprinting. The DMD is an enhancer blocker that binds CTCF in a methylation-sensitive manner. CTCF bound to the unmethylated maternal allele silences expression...
  66. ncbi The human enhancer blocker CTC-binding factor interacts with the transcription factor Kaiso
    Pierre Antoine Defossez
    CNRS UMR5161, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
    J Biol Chem 280:43017-23. 2005
    CTC-binding factor (CTCF) is a DNA-binding protein of vertebrates that plays essential roles in regulating genome activity through its capacity to act as an enhancer blocker...
  67. ncbi Familial cases of point mutations in the XIST promoter reveal a correlation between CTCF binding and pre-emptive choices of X chromosome inactivation
    Elena M Pugacheva
    Molecular Pathology Section, Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5640 Fishers Lane, Twinbrook I Rm 1417, Rockville, MD 20852, USA
    Hum Mol Genet 14:953-65. 2005
    ..Here we identify this factor as CTCF, a conserved protein with a 11 Zn-finger (ZF) domain that can mediate multiple sequence-specificity and ..
  68. ncbi Interaction of DNA fragmentation factor (DFF) with DNA reveals an unprecedented mechanism for nuclease inhibition and suggests that DFF can be activated in a DNA-bound state
    Christian Korn
    Institute of Biochemistry, Justus Liebig University Giessen, 35392 Giessen, Germany
    J Biol Chem 280:6005-15. 2005
    ..In transfected HeLa cells transiently expressed DFF associates with chromatin, suggesting that DFF could be activated during apoptosis in a DNA-bound state...
  69. pmc An antisense RNA regulates the bidirectional silencing property of the Kcnq1 imprinting control region
    Noopur Thakur
    Department of Development and Genetics, Evolution Biology Centre, Uppsala University, Norbyvagen 18A, S 752 36 Uppsala, Sweden
    Mol Cell Biol 24:7855-62. 2004
    ..Double-stranded RNA (dsRNA)-mediated RNA interference is unlikely to be involved, as the ICR is active irrespective of the simultaneous production of dsRNA from the genes it silences...
  70. ncbi Both CTCF-dependent and -independent insulators are found between the mouse T cell receptor alpha and Dad1 genes
    Frédérique Magdinier
    Laboratory of Molecular Biology, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 0504, USA
    J Biol Chem 279:25381-9. 2004
    ..report that one of these sites, not previously examined, strongly binds the insulator protein CCTC-binding factor (CTCF) in vitro and in vivo and can function in an enhancer blocking assay...
  71. ncbi An evolutionarily conserved putative insulator element near the 3' boundary of the imprinted Igf2/H19 domain
    Ko Ishihara
    Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Graduate University for Advanced Studies, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Hum Mol Genet 11:1627-36. 2002
    ..We have identified a binding site for CTCF, a nuclear factor that mediates insulator activity in vertebrates, in the intergenic region...
  72. pmc Conserved CTCF insulator elements flank the mouse and human beta-globin loci
    Catherine M Farrell
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 22:3820-31. 2002
    A binding site for the transcription factor CTCF is responsible for enhancer-blocking activity in a variety of vertebrate insulators, including the insulators at the 5' and 3' chromatin boundaries of the chicken beta-globin locus...
  73. pmc CTCF-binding elements mediate control of V(D)J recombination
    Chunguang Guo
    Howard Hughes Medical Institute, The Children s Hospital, The Immune Disease Institute, Department of Genetics, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 477:424-30. 2011
    ..Functionally, IGCR1 uses CTCF looping/insulator factor-binding elements and, correspondingly, mediates Igh loops containing distant enhancers...
  74. doi Sumoylation modulates a domain in CTCF that activates transcription and decondenses chromatin
    Neal S Kitchen
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Cell Biochem 111:665-75. 2010
    b>CTCF is a multipurpose transcription factor with activation, repression, and insulator activity. It also participates in regulating chromatin architecture by maintaining open chromatin and mediating long-range chromosomal interactions...
  75. pmc Comparative epigenomic analysis of murine and human adipogenesis
    Tarjei S Mikkelsen
    Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA
    Cell 143:156-69. 2010
    We report the generation and comparative analysis of genome-wide chromatin state maps, PPARγ and CTCF localization maps, and gene expression profiles from murine and human models of adipogenesis...
  76. pmc Mediation of CTCF transcriptional insulation by DEAD-box RNA-binding protein p68 and steroid receptor RNA activator SRA
    Hongjie Yao
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Genes Dev 24:2543-55. 2010
    CCCTC-binding factor (CTCF) is a DNA-binding protein that plays important roles in chromatin organization, although the mechanism by which CTCF carries out these functions is not fully understood...
  77. doi CTCF binding is not the epigenetic mark that establishes post-fertilization methylation imprinting in the transgenic H19 ICR
    Hitomi Matsuzaki
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Hum Mol Genet 19:1190-8. 2010
    ..In the present study, we investigated the requirements for the CTCF-binding sites of the ICR in the acquisition of post-fertilization methylation...
  78. pmc Nicotinamide adenine dinucleotide (NAD)-regulated DNA methylation alters CCCTC-binding factor (CTCF)/cohesin binding and transcription at the BDNF locus
    Jufang Chang
    Department of Genetics, and Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 107:21836-41. 2010
    ..Increased methylation at this promoter triggered the dissociation of the insulator protein CTCF as well as the accompanying cohesin from the BDNF locus...
  79. pmc CTCF-dependent chromatin bias constitutes transient epigenetic memory of the mother at the H19-Igf2 imprinting control region in prospermatogonia
    Dong Hoon Lee
    Department of Molecular and Cellular Biology, Beckman Research Institute, Duarte, CA, USA
    PLoS Genet 6:e1001224. 2010
    ..the chromatin bias, and also the delayed methylation establishment in the maternal allele, depended on functional CTCF insulator binding sites in the ICR...
  80. doi Functional analysis of CTCF during mammalian limb development
    Natalia Soshnikova
    Department of Zoology and Animal Biology, University of Geneva, Switzerland
    Dev Cell 19:819-30. 2010
    CCCTC-binding factor (CTCF) is a nuclear zinc-finger protein that displays insulating activity in a variety of biological assays...
  81. pmc CCCTC-binding factor and the transcription factor T-bet orchestrate T helper 1 cell-specific structure and function at the interferon-gamma locus
    Masayuki Sekimata
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Immunity 31:551-64. 2009
    ..IFNG) transcription, which is embedded within the human IL26 gene, compromised of a single CCCTC-binding factor (CTCF) binding site and retained in all mammals, even surviving near-complete evolutionary deletion of the equivalent ..
  82. pmc CTCF promotes muscle differentiation by modulating the activity of myogenic regulatory factors
    Paul Delgado-Olguín
    Gladstone Institute of Cardiovascular Disease, Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA
    J Biol Chem 286:12483-94. 2011
    b>CTCF nuclear factor regulates many aspects of gene expression, largely as a transcriptional repressor or via insulator function. Its roles in cellular differentiation are not clear. Here we show an unexpected role for CTCF in myogenesis...
  83. pmc Novel cis-regulatory function in ICR-mediated imprinted repression of H19
    Folami Y Ideraabdullah
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Dev Biol 355:349-57. 2011
    ..b>CTCF binding sites and DNA methylation at the ICR have previously been identified as key cis-acting elements required ..
  84. pmc Endonuclease-sensitive regions of human spermatozoal chromatin are highly enriched in promoter and CTCF binding sequences
    Ali Arpanahi
    Reproduction and Early Development Unit, Leeds Institute of Genetics and Health Therapeutics, University of Leeds, Leeds, United Kingdom
    Genome Res 19:1338-49. 2009
    ..with gene regulatory regions, including many promoter sequences and sequences recognized by CCCTC-binding factor (CTCF). Similar differential packaging of promoters is observed in the spermatozoal chromatin of both mouse and man...
  85. pmc Nonallelic transcriptional roles of CTCF and cohesins at imprinted loci
    Shu Lin
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 31:3094-104. 2011
    ..in transcriptional regulation and insulation through genome-wide colocalization with the insulator protein CTCF, including involvement at the imprinted H19/Igf2 locus...
  86. pmc CTCF regulates ataxin-7 expression through promotion of a convergently transcribed, antisense noncoding RNA
    Bryce L Sopher
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    Neuron 70:1071-84. 2011
    ..The ataxin-7 repeat and translation start site are flanked by binding sites for CTCF, a highly conserved multifunctional transcription regulator...
  87. pmc Regulation of Pax6 by CTCF during induction of mouse ES cell differentiation
    Jie Gao
    Division of Molecular Medicine, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Torrance, California, United States of America
    PLoS ONE 6:e20954. 2011
    ..We report that Pax6 expression in mouse ES cells was controlled by CCCTC binding factor (CTCF) through a promoter repression mechanism...
  88. pmc A boundary element between Tsix and Xist binds the chromatin insulator Ctcf and contributes to initiation of X-chromosome inactivation
    Rebecca J Spencer
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114, USA
    Genetics 189:441-54. 2011
    ..Here, we investigate the region and discover a conserved element, RS14, that presents a strong binding site for Ctcf protein...
  89. pmc Restraint of angiogenesis by zinc finger transcription factor CTCF-dependent chromatin insulation
    Ming Tang
    Department of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL 32610 3633, USA
    Proc Natl Acad Sci U S A 108:15231-6. 2011
    ..Here we show that the chromatin insulator-binding factor CTCF binds to the proximal promoter of VEGF...
  90. pmc The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and counting
    Mary E Donohoe
    Howard Hughes Medical Institute, USA
    Nature 460:128-32. 2009
    ..Xite, two regulatory noncoding RNA genes of the X-inactivation centre, and also complexes with XCI trans-factors, Ctcf and Yy1 (ref. 17), through protein-protein interactions...
  91. ncbi CTCF binding sites promote transcription initiation and prevent DNA methylation on the maternal allele at the imprinted H19/Igf2 locus
    Nora Engel
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Hum Mol Genet 15:2945-54. 2006
    ..Four repeats in the DMD bind CTCF on the maternal allele and have been proposed to recruit methylation on the paternal allele...
  92. doi ATRX partners with cohesin and MeCP2 and contributes to developmental silencing of imprinted genes in the brain
    Kristin D Kernohan
    Department of Paediatrics, 800 Commissioners Road East, London, ON N6C 2V5, Canada
    Dev Cell 18:191-202. 2010
    ..Importantly, we show that ATRX loss of function alters enrichment of cohesin, CTCF, and histone modifications at the H19 ICR, without affecting DNA methylation on the paternal allele...

Research Grants4

  1. Epigenetic effects if endocrine disruptors in fetal germ cells
    PIROSKA E SZABO; Fiscal Year: 2010
    ....
  2. The Role of Double Strand Breaks in Carcinogenesis
    CHRISTOPHER KEMP; Fiscal Year: 2006
    ..Understanding the functional interaction of the P13 Ks, in regulating p53, apoptosis, development and carcinogenesis at the level of the whole animal is a necessary link to apply knowledge gained from cell culture models to the clinic. ..
  3. Mouse Models of Tumor Progression and Therapy Response
    CHRISTOPHER KEMP; Fiscal Year: 2007
    ..These experiments will reveal the molecular and cellular basis for the poor clinical outcome associated with p27 deficient tumors. This knowledge can then be applied to improve treatment design and regimen in the clinical setting. ..
  4. Structure and Function of CTCF: Mouse Model Studies
    Galina Filippova; Fiscal Year: 2007
    DESCRIPTION (provided by applicant): CTCF is a highly conserved 11 Zn finger (ZF) transcription factor and insulator protein...