Dbx1

Summary

Gene Symbol: Dbx1
Description: developing brain homeobox 1
Alias: AI426026, Dbx, homeobox protein DBX1, Mmox C, developing brain homeobox protein 1
Species: mouse

Top Publications

  1. ncbi Molecular regionalization of the neocortex is disrupted in Fgf8 hypomorphic mutants
    Sonia Garel
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, CA 94143 0984, USA
    Development 130:1903-14. 2003
  2. ncbi All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3
    C Brian Bai
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Dev Cell 6:103-15. 2004
  3. ncbi Genetic identification of spinal interneurons that coordinate left-right locomotor activity necessary for walking movements
    Guillermo M Lanuza
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuron 42:375-86. 2004
  4. doi A crucial role for primary cilia in cortical morphogenesis
    Marc A Willaredt
    Interdisciplinary Center for Neurosciences, Department of Anatomy, University of Heidelberg, 69120 Heidelberg, Germany
    J Neurosci 28:12887-900. 2008
  5. ncbi Expression patterns of developmental control genes in normal and Engrailed-1 mutant mouse spinal cord reveal early diversity in developing interneurons
    M P Matise
    New York University Medical School, Skirball Institute of Biomolecular Medicine, Developmental Genetics Program, New York, New York 10016, USA
    J Neurosci 17:7805-16. 1997
  6. pmc Developmental origin of preBötzinger complex respiratory neurons
    Paul A Gray
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 30:14883-95. 2010
  7. pmc Physiological and morphological properties of Dbx1-derived respiratory neurons in the pre-Botzinger complex of neonatal mice
    Maria Cristina D Picardo
    Department of Applied Science, McGlothlin Street Hall, Room 318, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    J Physiol 591:2687-703. 2013
  8. pmc Automated cell-specific laser detection and ablation of neural circuits in neonatal brain tissue
    Xueying Wang
    Department of Applied Science, McGlothlin Street Hall, Room 318, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    J Physiol 591:2393-401. 2013
  9. ncbi Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalon
    K Yun
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, LPPI, University of California, San Francisco, Box 0984, San Francisco, CA 94143 0984, USA
    Development 128:193-205. 2001
  10. ncbi A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord
    A Pierani
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Cell 97:903-15. 1999

Scientific Experts

  • Christopher A Del Negro
  • Scott D Weatherbee
  • Gonzalo Alvarez-Bolado
  • A S Shum
  • Vassiliki Fotaki
  • Paul Gray
  • Rebecca Lee Yean Wong
  • Celine Zimmer
  • Benjamin L Allen
  • Sarah E Craven
  • Alessandra Pierani
  • Maria Cristina D Picardo
  • Joshua G Corbin
  • Katie Sokolowski
  • Xueying Wang
  • Johan Ericson
  • Anne Teissier
  • Tsutomu Hirata
  • Wolfgang Wurst
  • Laura A Cocas
  • Ronald R Waclaw
  • Andrew Kottick
  • Tou Yia Vue
  • Shubha Tole
  • Kenneth Campbell
  • Ashwin S Shetty
  • Nilima Prakash
  • Yasushi Nakagawa
  • Andrew P McMahon
  • Nicoletta Kessaris
  • Oscar Marin
  • Amélie Griveau
  • Diego M Gelman
  • Takashi Inoue
  • Gareth B Miles
  • Xiaoting Wu
  • Andrew Lam
  • Shigeyuki Esumi
  • A Pierani
  • Livio Oboti
  • Tuyen Tran
  • Srinivasan Tupal
  • Ulrika Marklund
  • Tadashi Nomura
  • Nicholas Rogers
  • Luca G Di Giovannantonio
  • Guillermo M Lanuza
  • Victoria T Akins
  • John A Hayes
  • Zachary B Gaber
  • Alexander M Holtz
  • Jonathan T Eggenschwiler
  • Robert M Cabrera
  • Oleg V Bulgakov
  • Francesca Chiara
  • Frédéric Causeret
  • Diego Gelman
  • Edwin S Monuki
  • Sebastian Stuebner
  • Julien Bouvier
  • Sonia Garel
  • Andreas Holz
  • Tomomi Shimogori
  • Lisa A Ehrman
  • Nora Emöke Szabó
  • Ramón Pla
  • Rosalind S E Carney
  • Laskaro Zagoraiou
  • Jennifer A Chan
  • Ariadna Perez-Balaguer
  • Nicholas Genethliou
  • Marc A Willaredt
  • Emma R Andersson
  • Emi Kinameri
  • Jun Aruga
  • Elisabet Andersson
  • Vishakha S Mangale
  • Robert M Brownstone
  • James F Martin
  • David C Martinelli
  • Vanisha Lakhina
  • Carina Hanashima
  • Melanie Lebel
  • Nuria Flames
  • Abraham Pachikara
  • Thomas M Jessell
  • Bei Wang
  • T M Jessell
  • Katrin Götz
  • Kathryn V Anderson

Detail Information

Publications93

  1. ncbi Molecular regionalization of the neocortex is disrupted in Fgf8 hypomorphic mutants
    Sonia Garel
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, CA 94143 0984, USA
    Development 130:1903-14. 2003
    ..Overall, our study demonstrates the role of endogenous Fgf8 in regulating early gradients of transcription factors in cortical progenitor cells and in molecular regionalization of the cortical plate...
  2. ncbi All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3
    C Brian Bai
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Dev Cell 6:103-15. 2004
    ..Therefore, in the spinal cord all Hh signaling is Gli dependent. Furthermore, a combination of Gli2 and Gli3 is required to regulate motor neuron development and spatial patterning of ventral spinal cord progenitors...
  3. ncbi Genetic identification of spinal interneurons that coordinate left-right locomotor activity necessary for walking movements
    Guillermo M Lanuza
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuron 42:375-86. 2004
    ..a discrete subset of commissural spinal interneurons, whose fate is controlled by the activity of the homeobox gene Dbx1, has a critical role in controlling the left-right alternation of motor neurons innervating hindlimb muscles...
  4. doi A crucial role for primary cilia in cortical morphogenesis
    Marc A Willaredt
    Interdisciplinary Center for Neurosciences, Department of Anatomy, University of Heidelberg, 69120 Heidelberg, Germany
    J Neurosci 28:12887-900. 2008
    ..Interestingly, the ultrastructure and morphology of ventricular cilia in the cobblestone mutants remains intact. Together, these results indicate a critical role for ciliary function in the developing forebrain...
  5. ncbi Expression patterns of developmental control genes in normal and Engrailed-1 mutant mouse spinal cord reveal early diversity in developing interneurons
    M P Matise
    New York University Medical School, Skirball Institute of Biomolecular Medicine, Developmental Genetics Program, New York, New York 10016, USA
    J Neurosci 17:7805-16. 1997
    ..Rather, it is suggested that En-1 may function to distinguish a subset of interneurons during the later maturation of the spinal cord...
  6. pmc Developmental origin of preBötzinger complex respiratory neurons
    Paul A Gray
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 30:14883-95. 2010
    ..we show, in mice, that the "core" of preBötC SST(+)/NK1R(+)/SST 2a receptor(+) (SST2aR) neurons, are derived from Dbx1-expressing progenitors...
  7. pmc Physiological and morphological properties of Dbx1-derived respiratory neurons in the pre-Botzinger complex of neonatal mice
    Maria Cristina D Picardo
    Department of Applied Science, McGlothlin Street Hall, Room 318, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    J Physiol 591:2687-703. 2013
    ..rhythm-generating preBötC neurons derive from a single genetic line that expresses the transcription factor Dbx1, but the cellular mechanisms of rhythmogenesis remain incompletely understood...
  8. pmc Automated cell-specific laser detection and ablation of neural circuits in neonatal brain tissue
    Xueying Wang
    Department of Applied Science, McGlothlin Street Hall, Room 318, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    J Physiol 591:2393-401. 2013
    ....
  9. ncbi Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalon
    K Yun
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, LPPI, University of California, San Francisco, Box 0984, San Francisco, CA 94143 0984, USA
    Development 128:193-205. 2001
    ..The role of Pax6 in dorsalizing the telencephalon is similar to its role in the spinal cord, supporting the hypothesis that some dorsoventral patterning mechanisms are used at all axial levels of the central nervous system...
  10. ncbi A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord
    A Pierani
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Cell 97:903-15. 1999
    ..for this parallel pathway emerged from an analysis of the induction of ventral progenitors that express the Dbx homeodomain proteins and of Evx1/2 (V0) and En1 (V1) neurons...
  11. doi A novel transient glutamatergic population migrating from the pallial-subpallial boundary contributes to neocortical development
    Anne Teissier
    Centre National de la Recherche Scientifique Unité Mixte de Recherche 7592, Institut Jacques Monod, Universite Paris Diderot, 75205 Paris Cedex 13, France
    J Neurosci 30:10563-74. 2010
    ..Using genetic tracing in mice, we have identified a population of glutamatergic neurons generated by Dbx1-expressing progenitors at the pallial-subpallial boundary predominantly at embryonic day 12.5 (E12...
  12. ncbi Multiple origins of Cajal-Retzius cells at the borders of the developing pallium
    Franck Bielle
    Centre National de la Recherche Scientifique Unité Mixte de Recherche 8542, Ecole Normale Superieure, 46 rue d Ulm, 75005 Paris, France
    Nat Neurosci 8:1002-12. 2005
    ..The homeodomain transcription factor Dbx1 is expressed in restricted progenitor domains of the developing pallium: the ventral pallium (VP) and the septum...
  13. ncbi Regionalized expression of the Dbx family homeobox genes in the embryonic CNS of the mouse
    H Shoji
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Mech Dev 56:25-39. 1996
    Here we report the identification of a novel homeobox gene family Dbx in mouse, which consists of Dbx and Dbx2. The two genes share similar structural organization and are encoded by different chromosomes...
  14. pmc Role of Fgf8 signalling in the specification of rostral Cajal-Retzius cells
    Celine Zimmer
    National Institute for Medical Research NIMR, Medical Research Council MRC, Department of Molecular Neurobiology, London NW7 1AA, UK
    Development 137:293-302. 2010
    ..Together, our results shed light on the mechanisms specifying rostral CR cells and further emphasise the crucial role of telencephalic signalling centres in the generation of distinct CR cell populations...
  15. pmc Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codes
    Nuria Flames
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
    J Neurosci 27:9682-95. 2007
    ..Furthermore, the results of microtransplantation experiments in vivo corroborate that anatomically defined regions of the mouse subpallium, such as the medial ganglionic eminence, can be subdivided into functionally distinct domains...
  16. pmc Expression pattern of a murine homeobox gene, Dbx, displays extreme spatial restriction in embryonic forebrain and spinal cord
    S Lu
    Department of Biology, Yale University, New Haven, CT 06511
    Proc Natl Acad Sci U S A 89:8053-7. 1992
    Homeobox genes specify regional identity during development. A homeobox sequence that we have named Dbx was isolated from 13.5-day embryonic mouse telencephalon cDNA. The Dbx homeodomain shows highest sequence homology to Drosophila H2...
  17. doi Zic deficiency in the cortical marginal zone and meninges results in cortical lamination defects resembling those in type II lissencephaly
    Takashi Inoue
    Laboratory for Comparative Neurogenesis Behavioral and Developmental Disorders, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
    J Neurosci 28:4712-25. 2008
    ..These findings indicate that the Zic genes play critical roles in cortical development through regulating the proliferation of meningeal cells and the pial BM assembly...
  18. ncbi The role of Foxg1 and dorsal midline signaling in the generation of Cajal-Retzius subtypes
    Carina Hanashima
    Smilow Neuroscience Program and Department of Cell Biology, Smilow Research Center, New York University, New York, New York 10016, USA
    J Neurosci 27:11103-11. 2007
    ....
  19. ncbi Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1
    A Pierani
    Howard Hughes Medical Institute, Department of Biochemistry and, Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Neuron 29:367-84. 2001
    ..derive from adjacent progenitor domains that are distinguished by expression of the homeodomain proteins Dbx1 and Dbx2...
  20. doi A wide diversity of cortical GABAergic interneurons derives from the embryonic preoptic area
    Diego Gelman
    Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, Sant Joan d Alacant 03550, Spain
    J Neurosci 31:16570-80. 2011
    ..Using genetic fate mapping and in utero transplantation experiments, we demonstrate that Dbx1-expressing progenitor cells in the POA give rise to a small but highly diverse cohort of cortical interneurons, ..
  21. pmc Detailed expression analysis of regulatory genes in the early developing human neural tube
    Ulrika Marklund
    1 Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
    Stem Cells Dev 23:5-15. 2014
    ....
  22. pmc Synaptic Depression Influences Inspiratory-Expiratory Phase Transition in Dbx1 Interneurons of the preBötzinger Complex in Neonatal Mice
    Andrew Kottick
    Department of Applied Science, The College of William and Mary, Williamsburg, Virginia 23187
    J Neurosci 35:11606-11. 2015
    ..generates the rhythm underlying inspiratory breathing movements and its core interneurons are derived from Dbx1-expressing precursors...
  23. pmc Laser ablation of Dbx1 neurons in the pre-Bötzinger complex stops inspiratory rhythm and impairs output in neonatal mice
    Xueying Wang
    Department of Applied Science, The College of William and Mary, Williamsburg, United States
    elife 3:e03427. 2014
    ..complex (preBötC) that putatively comprise the core respiratory rhythm generator in mammals are derived from Dbx1-expressing precursors...
  24. pmc Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis
    Xiaoting Wu
    Department of Medical Genetics, Cambridge Institute for Medical Research CIMR, University of Cambridge, Cambridge CB2 0XY, UK
    Nat Commun 7:10533. 2016
    ..This may have relevance for diverse disease conditions, like Alzheimer's Disease or Crohn's Disease, associated with altered autophagy. ..
  25. pmc Molecular and behavioral profiling of Dbx1-derived neurons in the arcuate, lateral and ventromedial hypothalamic nuclei
    Katie Sokolowski
    Center for Neuroscience Research, Children s National Medical Center, 111 Michigan Avenue, NW, Washington, 20010, DC, USA
    Neural Dev 11:12. 2016
    ..Here, focusing on the embryonically expressed homeodomain-containing gene Developing Brain Homeobox 1 (Dbx1), we explored the relationship between embryonic lineage, post-natal neuronal identity and lineage-specific ..
  26. pmc Atoh1-dependent rhombic lip neurons are required for temporal delay between independent respiratory oscillators in embryonic mice
    Srinivasan Tupal
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, United States
    elife 3:e02265. 2014
    ..We tested the roles of Atoh1-, Phox2b-, and Dbx1-derived neurons (three groups that have known roles in respiration) in the generation and coordination of ..
  27. pmc Dbx1 is a direct target of SOX3 in the spinal cord
    Nicholas Rogers
    Discipline of Biochemistry, School of Molecular and Biomedical Sciences, University of Adelaide, Adelaide, Australia
    PLoS ONE 9:e95356. 2014
    ..Nineteen genes with abnormal expression were identified, including the homeobox gene Dbx1. Analysis of Sox3 null embryos revealed that Dbx1 was significantly reduced in the neural tube and developing brain ..
  28. pmc Specification of select hypothalamic circuits and innate behaviors by the embryonic patterning gene dbx1
    Katie Sokolowski
    Center for Neuroscience Research, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
    Neuron 86:403-16. 2015
    ..Here, we find that in the hypothalamus the developmentally regulated homeodomain-containing transcription factor Dbx1 is required for the generation of specific subclasses of neurons within the lateral hypothalamic area/zona incerta (..
  29. doi Otx2 cell-autonomously determines dorsal mesencephalon versus cerebellum fate independently of isthmic organizing activity
    Luca G Di Giovannantonio
    Institute of Genetics and Biophysics Adriano Buzzati Traverso, CNR, Via P Castellino 111, 80131 Naples, Italy
    Development 141:377-88. 2014
    ..In this context, Otx2 is cell-autonomously required in the m1a sub-domain to suppress cerebellar fate and promote mesencephalic differentiation independently of the MHB organizing activity. ..
  30. pmc Essential role for ligand-dependent feedback antagonism of vertebrate hedgehog signaling by PTCH1, PTCH2 and HHIP1 during neural patterning
    Alexander M Holtz
    Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Development 140:3423-34. 2013
    ..Overall, these data reveal an essential role for ligand-dependent feedback inhibition of vertebrate HH signaling governed collectively by PTCH1, PTCH2 and HHIP1. ..
  31. pmc Lhx2 regulates a cortex-specific mechanism for barrel formation
    Ashwin S Shetty
    Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India
    Proc Natl Acad Sci U S A 110:E4913-21. 2013
    ..These genes may mediate Lhx2 function in the formation of specialized neurocircuitry necessary for neocortical function. ..
  32. pmc PLZF regulates fibroblast growth factor responsiveness and maintenance of neural progenitors
    Zachary B Gaber
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America Broad Center for Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America Molecular Biology Interdepartmental Graduate Program, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America
    PLoS Biol 11:e1001676. 2013
    ..Together, these findings reveal a novel transcriptional strategy for spatially tuning the responsiveness of distinct neural progenitor groups to broadly distributed mitogenic signals in the embryonic environment. ..
  33. pmc Sonic hedgehog lineage in the mouse hypothalamus: from progenitor domains to hypothalamic regions
    Gonzalo Alvarez-Bolado
    Department of Neuroanatomy, University of Heidelberg, Im Neuenheimer Feld 307, 69120 Heidelberg, Germany
    Neural Dev 7:4. 2012
    ....
  34. pmc Early B-cell factors 2 and 3 (EBF2/3) regulate early migration of Cajal-Retzius cells from the cortical hem
    Francesca Chiara
    Department of Cell and Developmental Biology, University College London, UK
    Dev Biol 365:277-89. 2012
    ..These findings provide evidence that Ebfs directly regulate CR cell development...
  35. ncbi Pax-6 functions in boundary formation and axon guidance in the embryonic mouse forebrain
    G S Mastick
    Department of Biology, University of Michigan, Ann Arbor 48109, USA
    Development 124:1985-97. 1997
    ..are lost (Pax-6, Lim-1, Gsh-1) and a marker for mesencephalon is expanded rostrally into the prosencephalon (Dbx)...
  36. pmc Transcriptional analyses of two mouse models of spina bifida
    Robert M Cabrera
    Department of Nutritional Sciences, Dell Pediatric Research Institute, The University of Texas at Austin, Austin, TX 78723, USA
    Birth Defects Res A Clin Mol Teratol 94:782-9. 2012
    ..Spina bifida is one of the most common of all human structural birth defects. Despite considerable effort over several decades, the causes and mechanisms underlying this malformation remain poorly characterized...
  37. pmc Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis
    Emi Kinameri
    Molecular Neuropathology Group, RIKEN Brain Science Institute, Wako, Saitama, Japan
    PLoS ONE 3:e3859. 2008
    ..In Drosophila we recently characterized Hamlet, a transcription factor that mediates Notch signalling and neural cell fate...
  38. doi Spatially distinct functions of PAX6 and NKX2.2 during gliogenesis in the ventral spinal cord
    Nicholas Genethliou
    The Cyprus Institute of Neurology and Genetics, Airport Avenue, No 6, Agios Dometios 2370, Nicosia, Cyprus
    Biochem Biophys Res Commun 382:69-73. 2009
    ..These data provide important insights into specific functions of PAX6 and NKX2.2 during glial cell specification that have so far remained largely unexplored...
  39. pmc Proteoglycan interactions with Sonic Hedgehog specify mitogenic responses
    Jennifer A Chan
    Neurobiology Department, Harvard Medical School, Boston, Massachusetts, USA
    Nat Neurosci 12:409-17. 2009
    ..Because activation of the Shh pathway is a feature of diverse human cancers, selective stimulation of proliferation by Shh-proteoglycan interactions may also figure prominently in neoplastic growth...
  40. doi The role of Sonic hedgehog of neural origin in thalamic differentiation in the mouse
    Nora Emöke Szabó
    Department of Genes and Behavior, Max Planck Institute of Biophysical Chemistry, D 37077 Gottingen, Germany
    J Neurosci 29:2453-66. 2009
    ..In this way, the individual thalamic nuclei show differential dependence on Shh, Gbx2, or both for their differentiation. Additionally, Gbx2 is required for the survival of thalamic neurons...
  41. pmc Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala
    Tsutomu Hirata
    Center for Neuroscience Research, Children s National Medical Center, 111 Michigan Avenue, NW, Suite 645, Washington, DC 20010, USA
    Nat Neurosci 12:141-9. 2009
    ..distinct and early-specified telencephalic progenitor pools marked by the homeodomain transcription factor Dbx1 are major sources of neuronal cell diversity in the mature mouse amygdala...
  42. ncbi Mouse Fkbp8 activity is required to inhibit cell death and establish dorso-ventral patterning in the posterior neural tube
    Rebecca Lee Yean Wong
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, The Texas A and M University System Health Science Center, 2121 W Holcombe Blvd, Houston, TX 77030, USA
    Hum Mol Genet 17:587-601. 2008
    ..The mutant Fkbp8 allele is a new experimental model which will be useful in dissecting the pathogenesis of spinal NTDs, and enhance our understanding of the etiology of human NTDs...
  43. doi Shh dependent and independent maintenance of basal midbrain
    Ariadna Perez-Balaguer
    Instituto de Neurociencias de Alicante, CSIC and Universidad Miguel Hernandez, Sant Joan d Alacant, Spain
    Mech Dev 126:301-13. 2009
    ..Based on our results and recently published data, we suggest the existence of a specific genetic pathway for the specification of the mesencephalic red nucleus. Foxa2 could be the candidate gene that might control this genetic pathway...
  44. doi The embryonic preoptic area is a novel source of cortical GABAergic interneurons
    Diego M Gelman
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
    J Neurosci 29:9380-9. 2009
    ....
  45. doi Fzd3 and Fzd6 deficiency results in a severe midbrain morphogenesis defect
    Sebastian Stuebner
    Institute of Developmental Genetics, Helmholtz Centre Munich, German Research Centre for Environmental Health, and Technical University Munich, Deutsches Zentrum für Neurodegenerative Erkrankungen DZNE, Munich Neuherberg, Germany
    Dev Dyn 239:246-60. 2010
    ..Fzd3 and Fzd6 thus control proper midbrain morphogenesis by a yet unknown mechanism in the mouse...
  46. pmc Developmental origin of the neuronal subtypes that comprise the amygdalar fear circuit in the mouse
    Ronald R Waclaw
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Neurosci 30:6944-53. 2010
    ..Additional support for a dLGE origin of the ITCs was obtained in conditional mutants of the dLGE gene Sp8. Thus, our findings indicate diverse origins for the neuronal components that comprise the amygdalar fear circuit...
  47. doi Hindbrain interneurons and axon guidance signaling critical for breathing
    Julien Bouvier
    Institut de Neurobiologie Alfred Fessard, CNRS UPR 3294, Gif sur Yvette, France
    Nat Neurosci 13:1066-74. 2010
    ..We found that the homeobox gene Dbx1 controls the fate of glutamatergic interneurons required for preBötC rhythm generation in the mouse embryo...
  48. pmc Lack of motor neuron differentiation is an intrinsic property of the mouse secondary neural tube
    Alisa S W Shum
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong
    Dev Dyn 239:3192-203. 2010
    ..Taken together, these results support that the lack of motor neuron differentiation is an intrinsic property of the mouse secondary neural tube...
  49. pmc The transcription factors Nkx2.2 and Nkx2.9 play a novel role in floor plate development and commissural axon guidance
    Andreas Holz
    Cell and Molecular Biology, University of Braunschweig, Spielmannstrasse 7, 38106 Braunschweig, Germany
    Development 137:4249-60. 2010
    ..As both factors affect floor plate development, control of commissural axon trajectories might be the underlying mechanism...
  50. doi Wnt/β-catenin signaling is disrupted in the extra-toes (Gli3(Xt/Xt) ) mutant from early stages of forebrain development, concomitant with anterior neural plate patterning defects
    Vassiliki Fotaki
    Genes and Development Group, Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    J Comp Neurol 519:1640-57. 2011
    ..Our data reveal that Gli3 is required at the neural plate stage to regulate Wnt expression and Wnt/β-catenin signaling in the presumptive forebrain and confirm its previously proposed role in patterning the anterior neural plate...
  51. pmc Pax6 is required at the telencephalic pallial-subpallial boundary for the generation of neuronal diversity in the postnatal limbic system
    Laura A Cocas
    Center for Neuroscience Research, Children s Research Institute, Children s National Medical Center, Washington, DC 20010, USA
    J Neurosci 31:5313-24. 2011
    ..Thus, in PSB progenitors, Pax6 plays an important role in the generation of multiple subtypes of neurons that contribute to the amygdala and olfactory bulb...
  52. pmc Dbx1-expressing cells are necessary for the survival of the mammalian anterior neural and craniofacial structures
    Frédéric Causeret
    CNRS UMR 7592, Institut Jacques Monod, Univ Paris Diderot, Sorbonne Paris Cité, Paris, France
    PLoS ONE 6:e19367. 2011
    ..In this study, we identify five small subsets of progenitors expressing the transcription factor dbx1 in the cephalic region of developing mouse embryos at E8.5...
  53. ncbi Mosaic development of the olfactory cortex with Pax6-dependent and -independent components
    Tatsumi Hirata
    Division of Brain Function, National Institute of Genetics, Graduate University for Advanced Studies, Yata 1111, Mishima 411 8540, Japan
    Brain Res Dev Brain Res 136:17-26. 2002
    ....
  54. pmc Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo
    Emma R Andersson
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 3:e3517. 2008
    ....
  55. ncbi Tlx controls proliferation and patterning of lateral telencephalic progenitor domains
    Jan M Stenman
    Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, Ohio 45229 3039, USA
    J Neurosci 23:10568-76. 2003
    ..Our results show that, although Gsh2 and Tlx have additive effects on striatal development, they differentially regulate the establishment of ventral pallial identity...
  56. ncbi Paleocortex is specified in mice in which dorsal telencephalic patterning is severely disrupted
    Aditee Vyas
    Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India
    J Comp Neurol 466:545-53. 2003
    ..Furthermore, our in vitro data reveal that, if mechanisms outside the lateral telencephalon are involved in the specification of the paleocortex, they must act extremely early, prior to E10.5...
  57. ncbi Complementary roles for Nkx6 and Nkx2 class proteins in the establishment of motoneuron identity in the hindbrain
    Alexandre Pattyn
    Department of Cell and Molecular Biology, Karolinska Institute, S 171 77 Stockholm, Sweden
    Development 130:4149-59. 2003
    ..Thus, both visceral and somatic motoneuron differentiation appear to rely on the combined activity of cell intrinsic determinants, rather than on a single key determinant of neuronal cell fate...
  58. ncbi Tlx and Pax6 co-operate genetically to establish the pallio-subpallial boundary in the embryonic mouse telencephalon
    Jan Stenman
    Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, OH 45229 3039, USA
    Development 130:1113-22. 2003
    ..This correlates well with the malformation of the lateral and basolateral amygdala in Tlx mutants, both of which have been suggested to derive from ventral portions of the pallium...
  59. pmc Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity
    Madelen Persson
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, S 171 77 Stockholm, Sweden
    Genes Dev 16:2865-78. 2002
    ..Together these data raise the possibility that Gli proteins act as common mediators integrating Shh signals, and other sources of positional information, to control patterning throughout the ventral neural tube...
  60. pmc A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord
    Mark Wijgerde
    Department of Molecular and Cellular Biology, The Biolabs, Harvard University, Cambridge, Massachusetts 02138, USA
    Genes Dev 16:2849-64. 2002
    ..Further, Hh signaling extends into the dorsal half of the spinal cord including the intermediate Dbx expression domain...
  61. ncbi A sonic hedgehog-dependent signaling relay regulates growth of diencephalic and mesencephalic primordia in the early mouse embryo
    Makoto Ishibashi
    Department of Molecular and Cellular Biology, The Biolabs, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 129:4807-19. 2002
    ....
  62. ncbi Gata2 specifies serotonergic neurons downstream of sonic hedgehog
    Sarah E Craven
    Department of Molecular Biology, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Development 131:1165-73. 2004
    ..Our findings reveal that the identity of closely related 5-HT subclasses occurs through distinct responses of adjacent rostrocaudal progenitor domains to broad ventral inducers...
  63. ncbi The zebrafish fth1, slc3a2, men1, pc, fgf3 and cycd1 genes define two regions of conserved synteny between linkage group 7 and human chromosome 11q13
    J A Yoder
    Children s Research Institute, University of South Florida College of Medicine All Children s Hospital, Department of Pediatrics, 140 Seventh Avenue South, FL 33701, St Petersburg, USA
    Gene 261:235-42. 2000
    ..five full-length zebrafish cDNAs, fth1, slc3a2, prkri, cd81, and pc, as well as one putative human gene, DBX were identified and their map positions ascertained...
  64. ncbi Wnt signalling required for expansion of neural crest and CNS progenitors
    M Ikeya
    Centre for Molecular and Developmental Biology, Faculty of Science, Kyoto University, Japan
    Nature 389:966-70. 1997
    ..Given the widespread expression of different Wnt genes in discrete areas of the mammalian neural tube, this may represent a general model for the action of Wnt signalling in the developing CNS...
  65. ncbi Disruption of PAX6 function in mice homozygous for the Pax6Sey-1Neu mutation produces abnormalities in the early development and regionalization of the diencephalon
    J C Grindley
    Department of Cell Biology, Vanderbilt University Medical Center, Nashville, TN 37232 2175, USA
    Mech Dev 64:111-26. 1997
    ..Thus, PAX6 is essential for the normal development and regionalization of the diencephalon...
  66. ncbi Separate cis-acting elements determine the expression of mouse Dbx gene in multiple spatial domains of the central nervous system
    S Lu
    Department of Biology, Yale University, New Haven, CT 06511 201803, USA
    Mech Dev 58:193-202. 1996
    b>Dbx, a divergent homeobox gene, is expressed in a regionally restricted pattern in the developing mouse central nervous system (CNS)...
  67. ncbi Mapping of the ARIX homeodomain gene to mouse chromosome 7 and human chromosome 11q13
    K R Johnson
    Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland, Oregon, 97201 3098, USA
    Genomics 33:527-31. 1996
    ..3-q13.4. These map locations extend and further define regions of conserved synteny between mouse and human genomes and identify a new candidate gene for inherited developmental disorders linked to human 11q13...
  68. ncbi Distal-less and other homeobox genes in the development of the dentition
    K M Weiss
    Department of Anthropology, Penn State University, University Park 16802
    J Exp Zool 270:273-84. 1994
    ..Members of several classes have been isolated, including the Msx genes, two Dlx genes, and the Dbx, MHox, Mox2A genes...
  69. ncbi Mouse homeobox gene Dbx: sequence, gene structure and expression pattern during mid-gestation
    S Lu
    Department of Biology, Yale University, New Haven, CT 06511
    Mech Dev 47:187-95. 1994
    ..We previously reported the isolation of a mouse homeobox gene, Dbx, from the forebrain...
  70. pmc Detection of homeobox genes in development and evolution
    M T Murtha
    Department of Biology, Yale University, New Haven, CT 06511
    Proc Natl Acad Sci U S A 88:10711-5. 1991
    ..Cloning of three Antennapedia-related sequences from cnidarians provides evidence of ancient roles for homeobox genes early in metazoan evolution...
  71. ncbi Genetic mapping of a new homeobox gene to mouse chromosome 7
    K R Johnson
    Jackson Laboratory, Bar Harbor, Maine 04609
    Genomics 14:1107-9. 1992
    A newly identified homeobox gene designated Dbx has been mapped to mouse Chromosome (Chr) 7...
  72. ncbi FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues
    Oleg V Bulgakov
    The Berman Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Development 131:2149-59. 2004
    ..Although it is expressed broadly, FKBP8 is required to antagonize SHH signaling primarily in neural tissues, suggesting that hedgehog signal transduction is subject to cell-type specific modulation during mammalian development...
  73. ncbi Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord
    Qiubo Lei
    Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Development 131:3593-604. 2004
    ..Thus, multiple ventral neuronal types can develop in the absence of Gli function, but require balanced Gli protein activities for their correct patterning and differentiation...
  74. pmc Differential regulation of telencephalic pallial-subpallial boundary patterning by Pax6 and Gsh2
    Rosalind S E Carney
    Center for Neuroscience Research, Children s Research Institute, Children s National Medical Center, Washington, DC 20010, USA
    Cereb Cortex 19:745-59. 2009
    ..Thus, in addition to their well-characterized cross-repressive roles in dorsal/ventral patterning our analyses reveal important novel functions of Gsh2 and Pax6 in the regulation of PSB progenitor pool specification and patterning...
  75. pmc Lhx2 selector activity specifies cortical identity and suppresses hippocampal organizer fate
    Vishakha S Mangale
    Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India
    Science 319:304-9. 2008
    ..In addition to providing functional evidence for Lhx2 selector activity, these findings show that the cortical hem is a hippocampal organizer...
  76. ncbi Id4 regulates neural progenitor proliferation and differentiation in vivo
    Kyuson Yun
    Department of Pediatrics and Genetics and the Norris Cotton Cancer Center, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Development 131:5441-8. 2004
    ..These observations, together with evidence for the premature differentiation of early cortical stem cells, indicate that Id4 has a unique and complex function in regulating neural stem cell proliferation and differentiation...
  77. ncbi Homozygous Ft embryos are affected in floor plate maintenance and ventral neural tube patterning
    Katrin Götz
    Institut für Entwicklungs und Molekularbiologie der Tiere EMT, Heinrich Heine Universitat, Dusseldorf, Germany
    Dev Dyn 233:623-30. 2005
    ....
  78. ncbi Mouse Rab23 regulates hedgehog signaling from smoothened to Gli proteins
    Jonathan T Eggenschwiler
    Developmental Biology Program, Sloan Kettering Institute, New York, NY 10021, USA
    Dev Biol 290:1-12. 2006
    ..Instead, Rab23 appears to regulate subcellular localization of essential components of the Hedgehog pathway that act downstream of Smoothened and upstream of Gli proteins...
  79. pmc Patterns of neurogenesis and amplitude of Reelin expression are essential for making a mammalian-type cortex
    Tadashi Nomura
    Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research CTTAR, Tohoku University School of Medicine, Sendai, Japan
    PLoS ONE 3:e1454. 2008
    ..These lines of evidence shed light on the developmental programs underlying the evolution of the mammalian specific laminated cortex...
  80. ncbi Characterization of progenitor domains in the developing mouse thalamus
    Tou Yia Vue
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Comp Neurol 505:73-91. 2007
    ..To determine if pTH-C is composed of subdomains, we characterized expression of the homeodomain protein Dbx1 and the bHLH protein Olig2...
  81. pmc Spinal cholinergic interneurons regulate the excitability of motoneurons during locomotion
    Gareth B Miles
    Department of Anatomy and Neurobiology, Dalhousie University, Halifax, NS, Canada B3H 1X5
    Proc Natl Acad Sci U S A 104:2448-53. 2007
    ..These results highlight a unique component of spinal motor networks that is critical in ensuring that sufficient output is generated by motoneurons to drive motor behavior...
  82. pmc Gas1 extends the range of Hedgehog action by facilitating its signaling
    David C Martinelli
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21218, USA
    Genes Dev 21:1231-43. 2007
    ..Our data support a model in which GAS1 helps transform the Hedgehog protein gradient into the observed activity gradient. We propose that Gas1 is an evolutionarily novel, vertebrate-specific Hedgehog pathway regulator...
  83. ncbi Early thalamocortical tract guidance and topographic sorting of thalamic projections requires LIM-homeodomain gene Lhx2
    Vanisha Lakhina
    Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India
    Dev Biol 306:703-13. 2007
    ..Furthermore, the absence of Lhx2 in the ventral telencephalon selectively disrupts a subset of thalamic axon topography, indicating a specific rather than a general perturbation of cues in this structure...
  84. pmc Activation of Class I transcription factors by low level Sonic hedgehog signaling is mediated by Gli2-dependent and independent mechanisms
    Abraham Pachikara
    Department of Genetics, University of Pennsylvania, School of Medicine, Clinical Research Bldg, Room 470, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Dev Biol 305:52-62. 2007
    ..the adjacent hindbrain by inducing, rather than repressing, the expression of several Class I genes (Pax6, Dbx1, Dbx2). The Shh dependent activation of Class I genes was mediated, in part, by Gli2...
  85. pmc Distinct temporal requirements for the homeobox gene Gsx2 in specifying striatal and olfactory bulb neuronal fates
    Ronald R Waclaw
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Neuron 63:451-65. 2009
    ..These results demonstrate that Gsx2 specifies striatal projection neuron and olfactory bulb interneuron identity at distinct time points during telencephalic neurogenesis...
  86. pmc Sonic hedgehog signaling controls thalamic progenitor identity and nuclei specification in mice
    Tou Yia Vue
    Department of Neuroscience and Stem Cell Institute, University of Minnesota Medical School, University of Minnesota, Minneapolis, MN 55455, USA
    J Neurosci 29:4484-97. 2009
    ..We also show that increasing or decreasing Shh activity causes dramatic reorganization of postmitotic thalamic nuclei through altering the positional identity of progenitor cells...
  87. ncbi Different levels of repressor activity assign redundant and specific roles to Nkx6 genes in motor neuron and interneuron specification
    A Vallstedt
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, S 171 77, Stockholm, Sweden
    Neuron 31:743-55. 2001
    ....
  88. pmc A cluster of cholinergic premotor interneurons modulates mouse locomotor activity
    Laskaro Zagoraiou
    Howard Hughes Medical Institute, Kavli Institute for Brain Science, Department of Neuroscience, Columbia University, New York, NY 10032, USA
    Neuron 64:645-62. 2009
    ..Thus, V0(C) interneurons represent a defined class of spinal cholinergic interneurons with an intrinsic neuromodulatory role in the control of locomotor behavior...
  89. ncbi Gli2 and Gli3 play distinct roles in the dorsoventral patterning of the mouse hindbrain
    Melanie Lebel
    Program in Developmental Biology, The Hospital for Sick Children, Room 13 314, Toronto Medical Discovery Tower, Ontario, Canada
    Dev Biol 302:345-55. 2007
    ..Taken together, these observations indicate that Gli2 and Gli3 perform rhombomere-specific function during DV patterning of the hindbrain...
  90. ncbi Nkx6.1 controls migration and axon pathfinding of cranial branchio-motoneurons
    Myriam Müller
    Center for Molecular Neurobiology, Martinistrasse 85, 20251 Hamburg, Germany
    Development 130:5815-26. 2003
    ..Taken together, our findings demonstrate a requirement for Nkx6.1 in the development of postmitotic motoneurons, and suggest a cell-autonomous function in the control of branchio-motoneuron migration...
  91. ncbi Dose dependency of Disp1 and genetic interaction between Disp1 and other hedgehog signaling components in the mouse
    Hua Tian
    Department of Molecular and Cellular Biology, The Biolabs, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 131:4021-33. 2004
    ..Finally, in-vitro studies on Disp1 null mutant fibroblasts indicate that Disp1 is not essential for membrane targeting or release of lipid-modified Shh ligand...
  92. pmc Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates
    Miao Hsueh Chen
    Cardiovascular Research Institute, University of California, San Francisco 94143, USA
    Genes Dev 18:641-59. 2004
    ..These results suggest that soluble Hh multimeric complex travels in the morphogenetic field to activate Hh signaling in distant Hh-responsive cells...