Genomes and Genes
Gene Symbol: Dlx1
Description: distal-less homeobox 1
Alias: Dlx, Dlx-1, homeobox protein DLX-1, DII B
Publications104 found, 100 shown here
- Interneuron migration from basal forebrain to neocortex: dependence on Dlx genesS A Anderson
Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, CA 94143 0984, USA
Science 278:474-6. 1997..Finally, mice lacking the homeodomain proteins DLX-1 and DLX-2 show no detectable cell migration from the subcortical telencephalon to the neocortex and also have few ..
- Dlx1 and Dlx2 function is necessary for terminal differentiation and survival of late-born retinal ganglion cells in the developing mouse retinaJimmy de Melo
Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, Manitoba, R3E 3J7, Canada
Development 132:311-22. 2005..Expression begins at embryonic day 12.5 and is maintained until late embryogenesis for Dlx1, while Dlx2 expression extends to adulthood...
- A subpopulation of olfactory bulb GABAergic interneurons is derived from Emx1- and Dlx5/6-expressing progenitorsMinoree Kohwi
Department of Neurosurgery, University of California at San Francisco, San Francisco, California 94143, USA
J Neurosci 27:6878-91. 2007..Our results suggest that some OB interneurons are derived from progenitors outside the LGE and that precursors expressing what has classically been considered a pallial transcription factor generate GABAergic interneurons...
- Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and Wnt-3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundariesA Bulfone
Department of Psychiatry, University of California, San Francisco 94143 0984
J Neurosci 13:3155-72. 1993..5 mouse embryo. Three of the genes, Dlx-1, Dlx-2 (Tes-1), and Gbx-2, encode homeodomain-containing proteins, and one gene, Wnt-3, encodes a putative ..
- Molecular interaction between projection neuron precursors and invading interneurons via stromal-derived factor 1 (CXCL12)/CXCR4 signaling in the cortical subventricular zone/intermediate zoneMarie Catherine Tiveron
Institut de Biologie du Developpement de Marseille Luminy, Centre National de la Recherche Scientifique Université de Mediterranée, 13288 Marseille, France
J Neurosci 26:13273-8. 2006..Using MASH-1 mutant mice in concert with the interneuron marker DLX, we exclude that interneurons themselves produce the chemokine in an autocrine manner...
- Expression of the murine Dlx-1 homeobox gene during facial, ocular and limb developmentP Dolle
European Molecular Biology Laboratory, Heidelberg, Federal Republic of Germany
Differentiation 49:93-9. 1992We have analysed the expression pattern of the mouse homeobox containing gene Dlx-1. This gene harbors a homeodomain related to that found in the Drosophila distal-less (dll) gene...
- Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheresS Xuan
Cell Biology and Genetics Program, Cornell University Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Neuron 14:1141-52. 1995..These results suggest that BF-1 controls the morphogenesis of the telencephalon by regulating the rate of neuroepithelial cell proliferation and the timing of neuronal differentiation...
- Family of Ebf/Olf-1-related genes potentially involved in neuronal differentiation and regional specification in the central nervous systemS Garel
Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, Paris, France
Dev Dyn 210:191-205. 1997..These data suggest that Ebf genes may be involved in the control of neuronal differentiation in the CNS and in enforcing regional diversity in populations of post-mitotic forebrain neurons...
- Role of Dlx-1 and Dlx-2 genes in patterning of the murine dentitionB L Thomas
Department of Craniofacial Development, Guy s Hospital, London, UK
Development 124:4811-8. 1997..A role for Dlx-1 and Dlx-2 genes in patterning of the dentition has been proposed with the genes envisaged as participating in an '..
- Null mutation of Dlx-2 results in abnormal morphogenesis of proximal first and second branchial arch derivatives and abnormal differentiation in the forebrainM Qiu
Nina Ireland Laboratory of Developmental Neurobiology, University of California at San Francisco 94143 0984, USA
Genes Dev 9:2523-38. 1995..To determine the function of Dlx-2, we generated a null mutation in mice using gene targeting...
- Cloning and characterization of two members of the vertebrate Dlx gene familyA Simeone
International Institute of Genetics and Biophysics, Consiglio Nazionale delle Ricerche, Naples, Italy
Proc Natl Acad Sci U S A 91:2250-4. 1994..Similarly, the two human genes DLX1 and DLX2 are closely linked in a convergent configuration at 2q32, near the HOXD (previously HOX4) locus...
- Forebrain patterning defects in Small eye mutant miceA Stoykova
Max Planck Institute of Biophysical Chemistry, Gottingen, Germany
Development 122:3453-65. 1996..Our detailed analysis included a comparison of the expression of Pax6, Dlx1 and several other genes during embryonic mouse brain development in wild-type and in the mutant Small eye (Sey) ..
- Role of the Dlx homeobox genes in proximodistal patterning of the branchial arches: mutations of Dlx-1, Dlx-2, and Dlx-1 and -2 alter morphogenesis of proximal skeletal and soft tissue structures derived from the first and second archesM Qiu
Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, 94143 0984, USA
Dev Biol 185:165-84. 1997The Dlx homeobox gene family is expressed in a complex pattern within the embryonic craniofacial ectoderm and ectomesenchyme...
- Mutations of the homeobox genes Dlx-1 and Dlx-2 disrupt the striatal subventricular zone and differentiation of late born striatal neuronsS A Anderson
Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, 94143, USA
Neuron 19:27-37. 1997..Inroads to this subject have been made, due to the discovery of transcription factors, such as the Dlx genes, whose expression patterns suggest that they have a role in striatal development...
- Dlx genes encode DNA-binding proteins that are expressed in an overlapping and sequential pattern during basal ganglia differentiationJ K Liu
Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, 94143 0984, USA
Dev Dyn 210:498-512. 1997The Dlx gene family encodes homeodomain proteins that are required for forebrain and craniofacial development...
- Expression of the Emx-1 and Dlx-1 homeobox genes define three molecularly distinct domains in the telencephalon of mouse, chick, turtle and frog embryos: implications for the evolution of telencephalic subdivisions in amniotesA S Fernandez
CNRS URA 1414, Equipe Régionalisation nerveuse, Ecole Normale Superieure, 46, rue d Ulm 75230 PARIS Cedex 05 France
Development 125:2099-111. 1998..Expression of homeobox-containing genes of the Emx, Dlx and Pax families were used as markers of anteroposterior developmental subdivisions of the forebrain in mouse, ..
- Mash1 regulates neurogenesis in the ventral telencephalonS Casarosa
IGBMC, CNRS INSERM Universite Louis Pasteur, BP 163, CU de Strasbourg, France
Development 126:525-34. 1999..Therefore, Mash1 is an important regulator of neurogenesis in the ventral telencephalon, where it is required both to specify neuronal precursors and to control the timing of their production...
- An olfactory sensory map develops in the absence of normal projection neurons or GABAergic interneuronsA Bulfone
Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California, San Francisco 94143 0984, USA
Neuron 21:1273-82. 1998..with a homozygous deficiency in Tbr-1 lack most projection neurons, whereas mice with a homozygous deficiency in Dlx-1 and Dlx-2 lack most GABAergic interneurons...
- DLX-1, DLX-2, and DLX-5 expression define distinct stages of basal forebrain differentiationD D Eisenstat
Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry and Programs in Neuroscience and Developmental Biology, University of California at San Francisco, California 94143 0984, USA
J Comp Neurol 414:217-37. 1999The homeobox genes in the Dlx family are required for differentiation of basal forebrain neurons and craniofacial morphogenesis...
- A highly conserved enhancer in the Dlx5/Dlx6 intergenic region is the site of cross-regulatory interactions between Dlx genes in the embryonic forebrainT Zerucha
Loeb Health Research Institute at the Ottawa Hospital and Department of Medicine, University of Ottawa, Ottawa, Ontario K1Y 4E9, Canada
J Neurosci 20:709-21. 2000Four Dlx homeobox genes, Dlx1, Dlx2, Dlx5, and Dlx6 are expressed in the same primordia of the mouse forebrain with temporally overlapping patterns...
- Genetic control of dorsal-ventral identity in the telencephalon: opposing roles for Pax6 and Gsh2H Toresson
Wallenberg Neuroscience Center, Division of Neurobiology, Section for Developmental Neurobiology, Lund University, Solvegatan 17, S 223 62 Lund, Sweden
Development 127:4361-71. 2000..identity of early striatal progenitors and in its absence the ventral telencephalic regulatory genes Mash1 and Dlx are lost from most of the striatal germinal zone...
- The Gsh2 homeodomain gene controls multiple aspects of telencephalic developmentJ G Corbin
Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, NY 10016, USA
Development 127:5007-20. 2000..Taken together, our data support a model in which Gsh2, in response to sonic hedgehog signaling, plays a crucial role in multiple aspects of telencephalic development...
- Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalonK Yun
Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, LPPI, University of California, San Francisco, Box 0984, San Francisco, CA 94143 0984, USA
Development 128:193-205. 2001..The role of Pax6 in dorsalizing the telencephalon is similar to its role in the spinal cord, supporting the hypothesis that some dorsoventral patterning mechanisms are used at all axial levels of the central nervous system...
- Distinct cortical migrations from the medial and lateral ganglionic eminencesS A Anderson
Nina Ireland Laboratory of Developmental Neuroscience, Department of Psychiatry, University of California, San Francisco, CA 94143 0984, USA
Development 128:353-63. 2001..In addition, by comparing the phenotypes of mouse mutants with differential effects on MGE and LGE migration, we provide evidence that the MGE and LGE may give rise to different subtypes of cortical interneurons...
- Cell migration from the ganglionic eminences is required for the development of hippocampal GABAergic interneuronsS J Pleasure
Neurodevelopmental Disorders Laboratory, Department of Neurology, University of California, San Francisco, CA 94143, USA
Neuron 28:727-40. 2000..differentiation in the embryonic basal telencephalon (lateral and medial ganglionic eminences) through loss of Dlx1/2 homeobox function blocks the migration of virtually all GABAergic interneurons to the hippocampus...
- Sorting of striatal and cortical interneurons regulated by semaphorin-neuropilin interactionsO Marin
Department of Psychiatry, Nina Ireland Laboratory of Developmental Neurobiology, Langley Porter Psychiatric Institute, University of California, San Francisco, CA 94143, USA
Science 293:872-5. 2001....
- Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humansKunio Kitamura
Mitsubishi Kagaku Institute of Life Sciences, 11 Minamiooya, Machida, Tokyo 194 8511, Japan
Nat Genet 32:359-69. 2002..The present report is, to our knowledge, the first to use phenotypic analysis of a knockout mouse to identify a gene associated with an X-linked human brain malformation...
- Regulatory roles of conserved intergenic domains in vertebrate Dlx bigene clustersNoel Ghanem
Ottawa Health Research Institute and Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada K1Y 4E9
Genome Res 13:533-43. 2003Dlx homeobox genes of vertebrates are generally arranged as three bigene clusters on distinct chromosomes. The Dlx1/Dlx2, Dlx5/Dlx6, and Dlx3/Dlx7 clusters likely originate from duplications of an ancestral Dlx gene pair...
- Dlx1, Dlx2, Pax6, Brn3b, and Chx10 homeobox gene expression defines the retinal ganglion and inner nuclear layers of the developing and adult mouse retinaJimmy de Melo
Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba R3E 0V9, Canada
J Comp Neurol 461:187-204. 2003..We assessed Dlx gene expression in the developing and adult mouse retina. Dlx1 and Dlx2 are detected in retinal neuroprogenitors by embryonic day (E) 12.5 (Eisenstat et al.  J. Comp...
- Identification of a direct Dlx homeodomain target in the developing mouse forebrain and retina by optimization of chromatin immunoprecipitationQing Ping Zhou
Manitoba Institute of Cell Biology, 675 McDermot Avenue, Winnipeg, Manitoba, Canada
Nucleic Acids Res 32:884-92. 2004..Dlx genes are expressed in the developing forebrain, retina, craniofacial structures and limbs. Dlx1/Dlx2 double knockout mice die at birth with multiple defects including abnormal forebrain development and decreased ..
- The vertebrate ortholog of Aristaless is regulated by Dlx genes in the developing forebrainInma Cobos
Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, San Francisco, California 94158 2611, USA
J Comp Neurol 483:292-303. 2005..functionally relevant role in regulating Arx in vivo, as shown by the severe reduction in the expression of Arx in Dlx1/2 double-knockout mice...
- Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsyInma Cobos
Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California San Francisco, San Francisco, California 94158, USA
Nat Neurosci 8:1059-68. 2005..Here we show that Dlx1 is also required for regulating the functional longevity of cortical and hippocampal interneurons in the adult ..
- Cellular patterns of transcription factor expression in developing cortical interneuronsInma Cobos
Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California at San Francisco, San Francisco, CA 94158 2611, USA
Cereb Cortex 16:i82-8. 2006..patterns in differentiating and mature neocortical interneurons of 8 transcription factors, including 6 homeobox (Dlx1, Dlx2, Dlx5, Arx, Lhx6, Cux2), 1 basic helix-loop-helix, (NPAS1), and 1 bZIP (MafB)...
- Dlx homeobox genes promote cortical interneuron migration from the basal forebrain by direct repression of the semaphorin receptor neuropilin-2Trung N Le
Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba R3E 0V9, Canada
J Biol Chem 282:19071-81. 2007Dlx homeobox genes play an important role in vertebrate forebrain development. Dlx1/Dlx2 null mice die at birth with an abnormal cortical phenotype, including impaired differentiation and migration of GABAergic interneurons to the ..
- Dlx-dependent and -independent regulation of olfactory bulb interneuron differentiationJason E Long
Nina Ireland Laboratory of Developmental Neurobiology, University of California at San Francisco, San Francisco, California 94143, USA
J Neurosci 27:3230-43. 2007..Here we explore the mechanisms that result in olfactory bulb interneuron defects in Dlx1&2-/- (distal-less homeobox 1 and 2) and Mash1-/- (mammalian achaete-schute homolog 1) mutants...
- The proneural determinant MASH1 regulates forebrain Dlx1/2 expression through the I12b intergenic enhancerLuc Poitras
Center for Advanced Research in Environmental Genomics CAREG Department of Biology, University of Ottawa, Ottawa, Ontario, Canada
Development 134:1755-65. 2007..In the developing forebrain of mammals, the combined function of the Dlx1, Dlx2, Dlx5 and Dlx6 homeobox genes is necessary for the differentiation of the GABAergic interneurons born in the ..
- Distinct cis-regulatory elements from the Dlx1/Dlx2 locus mark different progenitor cell populations in the ganglionic eminences and different subtypes of adult cortical interneuronsNoel Ghanem
Centre for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5
J Neurosci 27:5012-22. 2007..These data suggest that interneuron subtypes use distinct combinations of Dlx1/Dlx2 enhancers from the time they are specified through adulthood.
- Dlx transcription factors promote migration through repression of axon and dendrite growthInma Cobos
Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94158, USA
Neuron 54:873-88. 2007..However, the mechanisms underlying this process are poorly understood. Here, we demonstrate that Dlx1/2 has a central role in restraining neurite growth of subpallial-derived immature interneurons at a stage when they ..
- Generation of Cre-transgenic mice using Dlx1/Dlx2 enhancers and their characterization in GABAergic interneuronsGregory B Potter
Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California at San Francisco, San Francisco, CA 94158 2611, USA
Mol Cell Neurosci 40:167-86. 2009b>DLX1 and DLX2 transcription factors are necessary for forebrain GABAergic neuron differentiation, migration, and survival...
- Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathwaysJason E Long
Department of Psychiatry and the Nina Ireland Laboratory of Developmental Neurobiology, University of California at San Francisco, San Francisco, CA 94158 2324, USA
Cereb Cortex 19:i96-106. 2009..We have begun to elucidate the transcriptional hierarchy of these genes with respect to the Dlx homeodomain genes, which are essential for differentiation of most gamma-aminobutyric acidergic projection neurons ..
- CXCR4 and CXCR7 have distinct functions in regulating interneuron migrationYanling Wang
Department of Psychiatry, University of California, San Francisco, CA 94158, USA
Neuron 69:61-76. 2011..On the other hand, CXCL12 stimulation of CXCR7, but not CXCR4, promoted MAP kinase signaling. Thus, we suggest that CXCR4 and CXCR7 have distinct roles and signal transduction in regulating interneuron movement and laminar positioning...
- A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortexHiroki Taniguchi
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
Neuron 71:995-1013. 2011..As such, this approach will accelerate the study of GABAergic circuits throughout the mammalian brain...
- Sequence, organization, and transcription of the Dlx-1 and Dlx-2 locusT McGuinness
Nina Ireland Laboratory of Developmental Neurobiology, University of California, San Francisco 94143 0984, USA
Genomics 35:473-85. 1996There are at least five murine Dlx genes that are related to the Drosophila Distal-less homeobox gene...
- Dlx-1 and Dlx-2 expression in the adult mouse brain: relationship to dopaminergic phenotypic regulationSachiko Saino-Saito
Weill Medical College of Cornell University at The Burke Medical Research Institute, White Plains, New York 10605, USA
J Comp Neurol 461:18-30. 2003Expression of the homeodomain-containing transcription factors Dlx-1 and Dlx-2 in the lateral (LGE) and medial (MGE) ganglionic eminences, subpallial embryonic structures, is required for generation of telencephalic interneurons...
- Multiple requirements for Hes 1 during early eye formationHae Young Lee
Department of Pediatrics, Northwestern University Medical School at Children s Memorial Institute for Education and Research, Chicago, IL 60614, USA
Dev Biol 284:464-78. 2005..Together, these studies demonstrate that Hes1, like Pax6, simultaneously regulates multiple developmental processes during optic development...
- Gating of Sema3E/PlexinD1 signaling by neuropilin-1 switches axonal repulsion to attraction during brain developmentSophie Chauvet
Developmental Biology Institute of Marseille Luminy, CNRS UMR 6216, University of Mediterranee, Case 907, Parc Scientifique de Luminy, 13288 Marseille Cedex 09, France
Neuron 56:807-22. 2007..Our data therefore reveal a "gating" function of neuropilins in semaphorin-plexin signaling during the assembly of forebrain neuronal circuits...
- Expression of the winged helix genes fkh-4 and fkh-5 defines domains in the central nervous systemK H Kaestner
Division of Molecular Biology of the Cell I, German Cancer Research Centre, Heidelberg, Germany
Mech Dev 55:221-30. 1996..5 centiMorgans (cM) and fkh-4 to chromosome 19 at 10.5 cM. The potential relationship of the two genes to the mouse mutations staggerer and small thymus (for fkh-5) and muscle deficient (for fkh-4) is discussed...
- Patterning of the dorsal telencephalon and cerebral cortex by a roof plate-Lhx2 pathwayE S Monuki
Division of Neurogenetics, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
Neuron 32:591-604. 2001..These findings provide evidence for the roof plate as an organizing center of the developing cortex and for a roof plate-Lhx2 pathway in cortical patterning...
- Endothelin-A receptor-dependent and -independent signaling pathways in establishing mandibular identityLouis Bruno Ruest
Department of Molecular, Cellular and Craniofacial Biology and the Birth Defects Center, University of Louisville, Louisville, KY 40292, USA
Development 131:4413-23. 2004..Together, our results suggest that the establishment of a 'mandibular identity' during lower jaw development requires both Ednra-dependent and -independent signaling pathways...
- Expression of the Rap1 guanine nucleotide exchange factor, MR-GEF, is altered in individuals with bipolar disorderAngela Bithell
Department of Psychological Medicine, Institute of Psychiatry, King s College London, London, United Kingdom
PLoS ONE 5:e10392. 2010In the rodent forebrain GABAergic neurons are generated from progenitor cells that express the transcription factors Dlx1 and Dlx2...
- The Rb/E2F pathway modulates neurogenesis through direct regulation of the Dlx1/Dlx2 bigene clusterNoel Ghanem
Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
J Neurosci 32:8219-30. 2012..show that the Rb/E2F pathway regulates key aspects of differentiation and migration through direct control of the Dlx1 and Dlx2 homeodomain proteins, required for interneuron specification...
- Chronic reduction in inhibition reduces receptive field size in mouse auditory cortexBryan A Seybold
Coleman Memorial Laboratory, Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 109:13829-34. 2012..cortical inhibitory interneurons after the critical period by studying mice with a conditional deletion of Dlx1. Following the loss of interneurons, baseline firing rates rose and tone-evoked responses became less sparse in ..
- Expression of the mouse goosecoid gene during mid-embryogenesis may mark mesenchymal cell lineages in the developing head, limbs and body wallS J Gaunt
Department of Molecular Embryology, AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, UK
Development 117:769-78. 1993..Our findings lead us to suggest that the goosecoid gene product plays a role in spatial programming within discrete embryonic fields, and possibly lineage compartments, during organogenesis stages of mouse development...
- Cranial and cardiac neural crest defects in endothelin-A receptor-deficient miceD E Clouthier
Howard Hughes Medical Institute, Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235, USA
Development 125:813-24. 1998..These observations define a novel genetic pathway for inductive communication between cephalic neural crest cells and their environmental counterparts...
- The early topography of thalamocortical projections is shifted in Ebf1 and Dlx1/2 mutant miceSonia Garel
Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California San Francisco, San Francisco, CA 94143 0984, USA
Development 129:5621-34. 2002..A similar shift in the topography of thalamocortical axons inside the basal ganglia and neocortex was observed in Dlx1/2(-/-) embryos, which also have an abnormal basal ganglia development...
- Forebrain gene expression domains and the evolving prosomeric modelLuis Puelles
Department of Human Anatomy and Psychobiology, Faculty of Medicine, University of Murcia, Murcia 30100, Spain
Trends Neurosci 26:469-76. 2003..By contrast, we continue to postulate that prosomeres p1-p3 (i.e. the pretectum, thalamus and prethalamus) are the caudal forebrain...
- Precocious retinal neurons: Pax6 controls timing of differentiation and determination of cell typeGary T Philips
Biology Department, University of Nevada, Biology 200, 1664 N Virginia Street, Reno, NV 89557, USA
Dev Biol 279:308-21. 2005..Subsequently, precocious neurons adopted a generic rather than a specific retinal neuron fate. Thus, Pax6 regulates the timing of retinal neurogenesis and couples it with specific neuron differentiation programs...
- Neuronal migration and ventral subtype identity in the telencephalon depend on SOX1Antigoni Ekonomou
Mammalian Neurogenesis Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital Campus, London, United Kingdom
PLoS Biol 3:e186. 2005..Our data also suggest that other SOXB1 members showing expression in specific neuronal populations are likely to play continuous roles from the establishment of precursors to their final differentiation...
- Regulation of Dlx5 and Dlx6 gene expression by p63 is involved in EEC and SHFM congenital limb defectsNadia Lo Iacono
Dulbecco Telethon Institute, Molecular Biotechnology Center, University of Torino, Via Nizza 52, Torino, 10126, Italy
Development 135:1377-88. 2008..Here, we show that p63 and Dlx proteins colocalize in the nuclei of the apical ectodermal ridge (AER)...
- Arx is a direct target of Dlx2 and thereby contributes to the tangential migration of GABAergic interneuronsGaia Colasante
Department of Biological and Technological Research, San Raffaele Scientific Institute, Stem Cell Research Institute, Vita e Salute San Raffaele University, 20132 Milan, Italy
J Neurosci 28:10674-86. 2008..Functional characterization of the Arx GABAergic enhancer element revealed its strict dependence on the activity of Dlx transcription factors...
- Impaired neurogenesis, learning and memory and low seizure threshold associated with loss of neural precursor cell survivinVanessa Coremans
KU Leuven, VIB Vesalius Research Center, Herestraat 49, Gasthuisberg O and N1, B3000 Leuven, Belgium
BMC Neurosci 11:2. 2010..Survivin is highly expressed in neural precursor cells in the brain, yet its function there has not been elucidated...
- Soluble guanylate cyclase generation of cGMP regulates migration of MGE neuronsShyamali Mandal
Department of Psychiatry, Neuroscience Program and the Nina Ireland Laboratory of Developmental Neurobiology, University of California San Francisco, San Francisco, California 94158 2324, Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, and Cold Spring Harbor Laboratories, Laurel Hollow, New York 11791
J Neurosci 33:16897-914. 2013..b>Dlx1/2(-/-) and Lhx6(-/-) mouse mutants, which exhibit MGE interneuron migration defects, have reduced expression of the ..
- Development of early-born γ-Aminobutyric acid hub neurons in mouse hippocampus from embryogenesis to adulthoodVincent Villette
INSERM U901, Marseille, 13009, France
J Comp Neurol 524:2440-61. 2016..We propose that a subpopulation of EBGNs forms into adulthood a scaffold of GABAergic projection neurons linking the hippocampus to distant structures. J. Comp. Neurol. 524:2440-2461, 2016. © 2016 Wiley Periodicals, Inc. ..
- Dlx6 regulates molecular properties of the striatum and central nucleus of the amygdalaBei Wang
Department of Psychiatry and the Nina Ireland Laboratory of Developmental Neurobiology, University of California San Francisco, San Francisco, California 94158 2324, USA
J Comp Neurol 519:2320-34. 2011..expression from the Dlx6-lacZ (Dlx6(LacZ) ) allele in heterozygotes (Dlx6(LacZ/+) ), with the expression of Dlx1, Dlx2, Dlx5 and Dlx6 RNA...
- Making sense of Dlx1 antisense RNAPetra Kraus
Stem Cell and Developmental Biology, Genome Institute of Singapore, Singapore 138672, Singapore
Dev Biol 376:224-35. 2013..to interrogate the biological significance of another distal-less antisense lncRNA, the previously uncharacterized Dlx1 antisense (Dlx1as) transcript...
- Order of six loci at 2q24-q31 and orientation of the HOXD locusE Rossi
Universita di Pavia, Italy
Genomics 24:34-40. 1994..of 9 homeobox genes of the Antennapedia class; EVX2, a homeobox gene related to Drosophila-even-skipped gene; DLX1 and DLX2, two homeobox genes related to the Drosophila distal-less gene; and TTN and NEB, the genes for the two ..
- A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryoA Simeone
International Institute of Genetics and Biophysics, CNR, Naples, Italy
EMBO J 12:2735-47. 1993..Its gene product contains a homeodomain of the bicoid class and is able to recognize and transactivate a bicoid target sequence...
- Vax1 is a novel homeobox-containing gene expressed in the developing anterior ventral forebrainM Hallonet
Max Planck Institut for Biophysical Chemistry, Department of Molecular and Cell Biology, Am Fassberg 11, Germany
Development 125:2599-610. 1998..Comparison of the limits of the expression territory of Vax1 with that of Dlx1, Pax6 and Emx1 indicates that the corticostriatal ridge is a complex structure with distinct identifiable genetic ..
- FGFs and BMP4 induce both Msx1-independent and Msx1-dependent signaling pathways in early tooth developmentM Bei
Genetics Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Development 125:4325-33. 1998..In addition, we have investigated the effects of FGFs and BMP4 on the distal-less homeobox genes Dlx1 and Dlx2 and we have clarified the relationship between Msx and Dlx gene function in the developing tooth...
- Ebf1 controls early cell differentiation in the embryonic striatumS Garel
Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, 75230 Paris Cedex 05, France
Development 126:5285-94. 1999....
- Progressive impairment of developing neuroendocrine cell lineages in the hypothalamus of mice lacking the Orthopedia geneD Acampora
International Institute of Genetics and Biophysics, Consiglio Nationale delle Ricerche CNR, 80125 Naples, Italy
Genes Dev 13:2787-800. 1999....
- MHC class I-restricted cytotoxic lymphocyte responses induced by enterotoxin-based mucosal adjuvantsC P Simmons
Department of Biochemistry, Imperial College of Science, Technology and Medicine, South Kensington, London, United Kingdom
J Immunol 163:6502-10. 1999..The results highlight the versatility of toxin-based adjuvants and suggest that LT potentiates CTL responses independently of IL-12 and IFN-gamma and probably by a mechanism unrelated to cross-priming...
- Pax6 regulates the identity of embryonic diencephalic neuronsG S Mastick
Department of Biology, University of Nevada, Reno, Nevada 89557, USA
Mol Cell Neurosci 17:190-207. 2001..2, and a subset of proliferating progenitors were labeled with an antibody against DLX transcription factors...
- Ectopic expression of the Dlx genes induces glutamic acid decarboxylase and Dlx expressionThorsten Stühmer
Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, LPPI, University of California at San Francisco, 401 Parnassus Avenue, San Francisco, CA 94143 0984, USA
Development 129:245-52. 2002..We also used this method to show cross-regulation between different Dlx family members. We find that Dlx2 can induce Dlx5 expression, and that Dlx1, Dlx2 and Dlx5 can induce expression from a Dlx5/6-lacZ enhancer/"reporter construct.
- Mosaic development of the olfactory cortex with Pax6-dependent and -independent componentsTatsumi Hirata
Division of Brain Function, National Institute of Genetics, Graduate University for Advanced Studies, Yata 1111, Mishima 411 8540, Japan
Brain Res Dev Brain Res 136:17-26. 2002....
- Cross-talk between Msx/Dlx homeobox genes and vitamin D during tooth mineralizationF Lezot
Laboratoire de Biologie Orofaciale et Pathologie INSERM EMI 0110, Université Paris 7 EA2380, IFR 58 Institut des Cordeliers, rue de l Ecole de Medecine, 75006 Paris, France
Connect Tissue Res 43:509-14. 2002..This study is devoted to potential cross-talk between vitamin D and Msx/Dlx transcription factors...
- Fgfr1 regulates patterning of the pharyngeal regionNina Trokovic
Institute of Biotechnology, Viikki Biocenter, 00014 University of Helsinki, Finland
Genes Dev 17:141-53. 2003..Our results indicate that Fgfr1 patterns the pharyngeal region to create a permissive environment for neural crest cell migration...
- Tlx and Pax6 co-operate genetically to establish the pallio-subpallial boundary in the embryonic mouse telencephalonJan Stenman
Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, OH 45229 3039, USA
Development 130:1113-22. 2003..This correlates well with the malformation of the lateral and basolateral amygdala in Tlx mutants, both of which have been suggested to derive from ventral portions of the pallium...
- A role for the mesenchymal T-box gene Brachyury in AER formation during limb developmentChunqiao Liu
Laboratory of Pathology, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA
Development 130:1327-37. 2003....
- Cajal-Retzius cells in the mouse: transcription factors, neurotransmitters, and birthdays suggest a pallial originRobert F Hevner
Department of Pathology, University of Washington, Harborview Medical Center, Box 359630, 325 Ninth Ave, Seattle, WA 98104 2499, USA
Brain Res Dev Brain Res 141:39-53. 2003..5. In contrast, interneurons expressed a subpallial transcription factor (Dlx), contained high levels of GABA, were frequently calbindin(+), and were born throughout corticogenesis (from E10...
- Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectodermDaisuke Kurokawa
Laboratory for Vertebrate Body Plan, Center for Developmental Biology CDB RIKEN Kobe, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe 650 0046, Japan
Development 131:3307-17. 2004..The AN enhancer region is conserved among mouse, human and Xenopus; moreover, the counterpart region in Xenopus exhibited an enhancer activity in mouse anterior neuroectoderm...
- CNTF/LIF/gp130 receptor complex signaling maintains a VZ precursor differentiation gradient in the developing ventral forebrainChristopher Gregg
Genes and Development Research Group, Hotchkiss Brain Institute, University of Calgary Faculty of Medicine, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
Development 132:565-78. 2005..These results demonstrate a novel region-specific role for CNTF/LIF/gp130 signaling in the development of the germinal layers of the embryonic telencephalon...
- Functional equivalence of Brn3 POU-domain transcription factors in mouse retinal neurogenesisLing Pan
Center for Aging and Developmental Biology, University of Rochester, Rochester, NY 14642, USA
Development 132:703-12. 2005..These results indicate that Brn3 factors are functionally equal and that their unique roles in neurogenesis are determined by the distinctive Brn3 spatiotemporal expression patterns...
- Novel transcription factor Satb2 interacts with matrix attachment region DNA elements in a tissue-specific manner and demonstrates cell-type-dependent expression in the developing mouse CNSOlga Britanova
Department of Molecular Biology of Neuronal Signals, Max Planck Institute for Experimental Medicine, 37075 Goettingen, Germany
Eur J Neurosci 21:658-68. 2005..In the Lbx1 mutants Satb2 expression is greatly reduced. We suggest that Satb2 may regulate differentiation of subsets of neurons at the level of higher order chromatin structure via binding to MARs...
- Characterization of Opr deficiency in mouse brain: subtle defects in dorsomedial telencephalon and medioventral forebrainKenryo Furushima
Laboratory for Animal Resources and Genetic Engineering, Center for Developmental Biology CDB, RIKEN Kobe, Kobe, Japan
Dev Dyn 232:1056-61. 2005..However, no defects were apparent in embryonic day 10.5 Opr null mutants, and subtle defects were later found in medial pallium and ventral structures of forebrain, suggesting the compensation of Opr deficiency by its cognate(s)...
- Developmental regulation of gonadotropin-releasing hormone gene expression by the MSX and DLX homeodomain protein familiesMarjory L Givens
Department of Reproductive Medicine, University of California, San Diego, La Jolla, California 92093 0674, USA
J Biol Chem 280:19156-65. 2005..Finally, mice lacking MSX1 or DLX1 and 2 show altered numbers of GnRH-expressing cells in regions where these factors likely function...
- Severe hearing loss in Dlxl mutant miceDaniel B Polley
Coleman Memorial Laboratory, Department of Otolaryngology, University of California, San Francisco, CA 94143, USA edu
Hear Res 214:84-8. 2006The Dlx homeobox gene family participates in regulating middle and inner ear development...
- A role for proneural genes in the maturation of cortical progenitor cellsOlivier Britz
Division of Molecular Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK
Cereb Cortex 16:i138-51. 2006..Taken together, these data support a model whereby Ngn2 and Mash1 function together to regulate the zonal distribution of progenitors in the developing neocortex...
- A comprehensive negative regulatory program controlled by Brn3b to ensure ganglion cell specification from multipotential retinal precursorsFeng Qiu
Center for Advanced Biotechnology and Medicine and Department of Pediatrics, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
J Neurosci 28:3392-403. 2008..Our data suggest that Brn3b specifies the RGC fate from multipotential precursors not only by promoting RGC differentiation but also by suppressing non-RGC differentiation programs as a safeguard mechanism...
- Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathwaysJason E Long
Department of Psychiatry and the Nina Ireland Laboratory of Developmental Neurobiology, University of California San Francisco, San Francisco, California 94158 2324, USA
J Comp Neurol 512:556-72. 2009..We have begun to elucidate the transcriptional hierarchy of these genes with respect to the Dlx homeodomain genes, which are essential for differentiation of most GABAergic projection neurons of the basal ..
- The canonical Wnt signaling activator, R-spondin2, regulates craniofacial patterning and morphogenesis within the branchial arch through ectodermal-mesenchymal interactionYong Ri Jin
Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Medical Center, 81 Research Drive, Scarborough, ME 04074, USA
Dev Biol 352:1-13. 2011..Thus, our study identifies Rspo2 as a mesenchyme-derived factor that plays critical roles in regulating BA1 patterning and morphogenesis through ectodermal-mesenchymal interaction and a novel genetic factor for cleft palate...
- Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrainM Price
European Molecular Biology Laboratory, Heidelberg, Germany
Neuron 8:241-55. 1992..abuts and partially overlaps with the expression domains of two other related homeobox-containing genes, TTF-1 and Dlx. The expression domains of the three genes in the developing prosencephalon coincide with anatomical boundaries, ..
- The evolution of the vertebrate Dlx gene familyD W Stock
Department of Anthropology, Pennsylvania State University, University Park 16802, USA
Proc Natl Acad Sci U S A 93:10858-63. 1996The vertebrate Dlx gene family consists of homeobox-containing transcription factors distributed in pairs on the same chromosomes as the Hox genes...
- Emx1 and Emx2 functions in development of dorsal telencephalonM Yoshida
Department of Morphogenesis, Institute of Molecular Embryology and Genetics IMEG, Kumamoto University School of Medicine, Japan
Development 124:101-11. 1997..In the more lateral region of telencephalon, Emx2-deficiency may be compensated for by Emx1 and vice versa. Phenotypes of newborn brains also suggest that these genes function in neurogenesis corresponding to their later expressions...
- Expression of a novel aristaless related homeobox gene 'Arx' in the vertebrate telencephalon, diencephalon and floor plateH Miura
Mitsubishi Kasei Institute of Life Sciences, Machida shi, Tokyo, Japan
Mech Dev 65:99-109. 1997..The expression of Arx in the ganglionic eminence and ventral thalamus overlapped regionally with that of Dlx1, but the cell layer where Arx is expressed differed from that of the Dlx1...
- A role for neural determination genes in specifying the dorsoventral identity of telencephalic neuronsC Fode
Institut de G en etique et de Biologie Mol eculaire et Cellulaire, Centre National de la Recherche Scient ifique Institut National de la Sant e et de la Recherche M edicale, Communaut e Urbaine de Strasbourg, France
Genes Dev 14:67-80. 2000....
- Generation of regionally specified neurons in expanded glial cultures derived from the mouse and human lateral ganglionic eminenceC Skogh
Division of Neurobiology, Wallenberg Neuroscience Center, Lund University, Solvegatan 17, BMC A11, S 221 84 Lund, Sweden
Mol Cell Neurosci 17:811-20. 2001..These results demonstrate that at least a subpopulation of neurogenic LGE precursors exhibit glial characteristics...
- Emx2 directs the development of diencephalon in cooperation with Otx2Y Suda
Department of Morphogenesis, Institute of Molecular Embryology and Genetics IMEG, Kumamoto University, Japan
Development 128:2433-50. 2001..Consequently, development of the dorsal and ventral thalamus and anterior pretectum requires cooperation between Emx2 and Otx2, whereas Emx2 expression is incompatible with development of the commissural region of the pretectum...
- Differential modulation of BMP signaling promotes the elaboration of cerebral cortical GABAergic neurons or oligodendrocytes from a common sonic hedgehog-responsive ventral forebrain progenitor speciesShau Yu Yung
Departments of Neuroscience, Rose F Kennedy Center for Research in Mental Retardation and Developmental Disabilities, Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Proc Natl Acad Sci U S A 99:16273-8. 2002....
- Variation of tooth number in mammalian dentition: connecting genetics, development, and evolutionSergio R P Line
Department of Morphology, Faculdade de Odontologia de Piracicaba, State University of Campinas, 13414 900Piracicaba SP, Brazil
Evol Dev 5:295-304. 2003....
- Dlx transcription factors regulate differentiation of dopaminergic neurons of the ventral thalamusGracie L Andrews
Biology and Biochemistry Departments, Cell and Molecular Biology Graduate Program, University of Nevada, Reno 89557, USA
Mol Cell Neurosci 23:107-20. 2003..for DLX function, the initial differentiation of the ventral thalamic neurons was examined in embryos mutant for Dlx1 and Dlx2...
- PIONEER AXON GUIDANCE IN THE EMBRYONIC FOREBRAINGRANT MASTICK; Fiscal Year: 2004..In addition, the mechanisms of axon growth during development may give insight into how regeneration of the nervous system may be stimulated following trauma or disease. ..
- Regulation of Laminar Fate in Cerebral CortexRobert Hevner; Fiscal Year: 2006..If molecular fates are aEered in heterochronic or Rein mutant cortex, this would suggest that certain aspects of laminar fate can be regulated post-mitotically. ..
- MECHANISMS OF NEURAL PATTERNING IN MAMMALIAN FOREBRAINGordon Fishell; Fiscal Year: 2007..abstract_text> ..
- REGIONAL PATTERNING IN THE VENTRAL TELENCEPHALONGORDON J FISHELL; Fiscal Year: 2010..If we can understand how this population is generated, we will take the first step towards assessing whether we can use gene or cell therapies to ameliorate the devasting consequences associated with cortical interneuron dysfunction. ..
- Longitudinal axon guidance by long range cues in the embryonic brainGRANT STEPHEN MASTICK; Fiscal Year: 2011....