Dlx2

Summary

Gene Symbol: Dlx2
Description: distal-less homeobox 2
Alias: AW121999, Dlx-2, Tes-1, homeobox protein DLX-2, DII A, homeobox protein TES-1
Species: mouse

Top Publications

  1. ncbi Independent regulation of Dlx2 expression in the epithelium and mesenchyme of the first branchial arch
    B L Thomas
    Department of Craniofacial Development, GKT Dental Institute, King s College, University of London, London, SE1 9RT, UK
    Development 127:217-24. 2000
  2. ncbi Dlx1 and Dlx2 function is necessary for terminal differentiation and survival of late-born retinal ganglion cells in the developing mouse retina
    Jimmy de Melo
    Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, Manitoba, R3E 3J7, Canada
    Development 132:311-22. 2005
  3. ncbi Expression pattern of Dlx3 during cell differentiation in mineralized tissues
    Sonia Ghoul-Mazgar
    Laboratoire de Biologie Oro faciale et Pathologie INSERM U 714, 15 21 rue de l Ecole de Médecine 75270, Universités Paris 7 and Paris 6 IFR58, Paris Cedex 06, France
    Bone 37:799-809. 2005
  4. ncbi GAD isoforms exhibit distinct spatiotemporal expression patterns in the developing mouse lens: correlation with Dlx2 and Dlx5
    Andrea Kwakowsky
    Department of Gene Technology and Developmental Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
    Dev Dyn 236:3532-44. 2007
  5. ncbi Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and Wnt-3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundaries
    A Bulfone
    Department of Psychiatry, University of California, San Francisco 94143 0984
    J Neurosci 13:3155-72. 1993
  6. ncbi A signaling cascade involving endothelin-1, dHAND and msx1 regulates development of neural-crest-derived branchial arch mesenchyme
    T Thomas
    Department of Pediatrics, Division of Cardiology and Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9148, USA edu
    Development 125:3005-14. 1998
  7. ncbi Transgenically ectopic expression of Bmp4 to the Msx1 mutant dental mesenchyme restores downstream gene expression but represses Shh and Bmp2 in the enamel knot of wild type tooth germ
    X Zhao
    Department of Cell and Molecular Biology and Center for Bioenvironmental Research, Tulane University, New Orleans, LA 70118, USA
    Mech Dev 99:29-38. 2000
  8. ncbi Combinatorial function of the homeodomain proteins Nkx2.1 and Gsh2 in ventral telencephalic patterning
    Joshua G Corbin
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA
    Development 130:4895-906. 2003
  9. ncbi T-brain-1: a homolog of Brachyury whose expression defines molecularly distinct domains within the cerebral cortex
    A Bulfone
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco 94143, USA
    Neuron 15:63-78. 1995
  10. pmc Dlx transcription factors promote migration through repression of axon and dendrite growth
    Inma Cobos
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94158, USA
    Neuron 54:873-88. 2007

Research Grants

Scientific Experts

Detail Information

Publications123 found, 100 shown here

  1. ncbi Independent regulation of Dlx2 expression in the epithelium and mesenchyme of the first branchial arch
    B L Thomas
    Department of Craniofacial Development, GKT Dental Institute, King s College, University of London, London, SE1 9RT, UK
    Development 127:217-24. 2000
    b>Dlx2, a member of the distal-less gene family, is expressed in the first branchial arch, prior to the initiation of tooth development, in distinct, non-overlapping domains in the mesenchyme and the epithelium...
  2. ncbi Dlx1 and Dlx2 function is necessary for terminal differentiation and survival of late-born retinal ganglion cells in the developing mouse retina
    Jimmy de Melo
    Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, Manitoba, R3E 3J7, Canada
    Development 132:311-22. 2005
    ..Expression begins at embryonic day 12.5 and is maintained until late embryogenesis for Dlx1, while Dlx2 expression extends to adulthood...
  3. ncbi Expression pattern of Dlx3 during cell differentiation in mineralized tissues
    Sonia Ghoul-Mazgar
    Laboratoire de Biologie Oro faciale et Pathologie INSERM U 714, 15 21 rue de l Ecole de Médecine 75270, Universités Paris 7 and Paris 6 IFR58, Paris Cedex 06, France
    Bone 37:799-809. 2005
    ..The present data on Dlx3 and recently published functional studies show that this transcription factor may be instrumental during growth in the control of matrix deposition and biomineralization in the entire skeleton...
  4. ncbi GAD isoforms exhibit distinct spatiotemporal expression patterns in the developing mouse lens: correlation with Dlx2 and Dlx5
    Andrea Kwakowsky
    Department of Gene Technology and Developmental Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
    Dev Dyn 236:3532-44. 2007
    ..This pattern correlates well with the expression of Dlx2 and Dlx5, known as upstream regulators of GAD...
  5. ncbi Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and Wnt-3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundaries
    A Bulfone
    Department of Psychiatry, University of California, San Francisco 94143 0984
    J Neurosci 13:3155-72. 1993
    ..These findings are consistent with neuromeric theories of forebrain development, and based upon them we suggest a model for forebrain segmentation...
  6. ncbi A signaling cascade involving endothelin-1, dHAND and msx1 regulates development of neural-crest-derived branchial arch mesenchyme
    T Thomas
    Department of Pediatrics, Division of Cardiology and Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9148, USA edu
    Development 125:3005-14. 1998
    ..Complete disruption of this molecular pathway results in growth failure of the branchial arches from apoptosis, while partial disruption leads to defects of branchial arch derivatives, similar to those seen in CATCH-22 syndrome...
  7. ncbi Transgenically ectopic expression of Bmp4 to the Msx1 mutant dental mesenchyme restores downstream gene expression but represses Shh and Bmp2 in the enamel knot of wild type tooth germ
    X Zhao
    Department of Cell and Molecular Biology and Center for Bioenvironmental Research, Tulane University, New Orleans, LA 70118, USA
    Mech Dev 99:29-38. 2000
    ..of a Bmp4 transgene driven by the mouse Msx1promoter in the dental mesenchyme restored the expression of Lef-1 and Dlx2 but neither Fgf3 nor syndecan-1 in the Msx1 mutant molar tooth germ...
  8. ncbi Combinatorial function of the homeodomain proteins Nkx2.1 and Gsh2 in ventral telencephalic patterning
    Joshua G Corbin
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA
    Development 130:4895-906. 2003
    ..1 dependent specification of oligodendrocytes. Therefore, both integrative and antagonistic interactions between homeodomain-containing transcription factors contribute to the patterning of the telencephalon...
  9. ncbi T-brain-1: a homolog of Brachyury whose expression defines molecularly distinct domains within the cerebral cortex
    A Bulfone
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco 94143, USA
    Neuron 15:63-78. 1995
    ..Tbr-1 expression is analyzed in the context of the prosomeric model. Topological maps are proposed for the organization of the dorsal telencephalon...
  10. pmc Dlx transcription factors promote migration through repression of axon and dendrite growth
    Inma Cobos
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94158, USA
    Neuron 54:873-88. 2007
    ..In Dlx1-/-;Dlx2-/- mutants, neurite length is increased and cells fail to migrate...
  11. ncbi Molecular interaction between projection neuron precursors and invading interneurons via stromal-derived factor 1 (CXCL12)/CXCR4 signaling in the cortical subventricular zone/intermediate zone
    Marie Catherine Tiveron
    Institut de Biologie du Developpement de Marseille Luminy, Centre National de la Recherche Scientifique Université de Mediterranée, 13288 Marseille, France
    J Neurosci 26:13273-8. 2006
    ..These results represent the first evidence for a molecular interaction between precursors of projection neurons and invading interneurons during corticogenesis...
  12. ncbi DLX-2, MASH-1, and MAP-2 expression and bromodeoxyuridine incorporation define molecularly distinct cell populations in the embryonic mouse forebrain
    M H Porteus
    Nina Ireland Laboratory of Developmental Biology, Department of Psychiatry, University of California, San Francisco 94143 0984
    J Neurosci 14:6370-83. 1994
    ....
  13. ncbi Role of Dlx-1 and Dlx-2 genes in patterning of the murine dentition
    B L Thomas
    Department of Craniofacial Development, Guy s Hospital, London, UK
    Development 124:4811-8. 1997
    ..This is the first indication that the development of different shaped teeth at different positions in the jaws is determined by independent genetic pathways...
  14. ncbi Dual role of brain factor-1 in regulating growth and patterning of the cerebral hemispheres
    C L Dou
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cereb Cortex 9:543-50. 1999
    ..These results raise the possibility that BF-1 may modulate both progenitor cell proliferation and regional patterning by regulating the expression or activity of inductive signals which act on the telencephalic neuroepithelium...
  15. ncbi Dlx2 progenitor migration in wild type and Nkx2.1 mutant telencephalon
    Susana Nery
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA
    Cereb Cortex 13:895-903. 2003
    The transcription factor Dlx2 is expressed widely throughout the ventral telencephalon. We have examined the in vitro and in vivo migration of Dlx2 progenitors originating from the different ganglionic eminences of both wild type and Nkx2...
  16. ncbi The adhesion molecule TAG-1 is required for proper migration of the superficial migratory stream in the medulla but not of cortical interneurons
    Myrto Denaxa
    University of Crete Medical School, Heraklion 71110, Crete, Greece
    Dev Biol 288:87-99. 2005
    ..Therefore, TAG-1 function is required for the survival of the neurons of some precerebellar nuclei, while it is not required for cortical interneuron migration in vivo...
  17. ncbi Expression of coiled-coil protein 1, a novel gene downstream of FGF2, in the developing brain
    Francesca Pellicano
    Beatson Laboratories for Cancer Research, Division of Cancer Sciences and Molecular Pathology, Faculty of Medicine, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK
    Gene Expr Patterns 6:285-93. 2006
    ..We observed that the expressed ccp1 protein was localised to endo/lysosomal compartment in the cell body as well as to vesicles present in the processes of primary cortical neurons and oligodendrocyte cell line...
  18. ncbi Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres
    S Xuan
    Cell Biology and Genetics Program, Cornell University Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Neuron 14:1141-52. 1995
    ..These results suggest that BF-1 controls the morphogenesis of the telencephalon by regulating the rate of neuroepithelial cell proliferation and the timing of neuronal differentiation...
  19. ncbi Isolation and characterization of a novel cDNA clone encoding a homeodomain that is developmentally regulated in the ventral forebrain
    M H Porteus
    Department of Psychiatry and Behavioral Sciences, Stanford Medical School, Stanford University, California 94305
    Neuron 7:221-9. 1991
    ..Within the central nervous system of the midgestation mouse embryo, it is expressed exclusively in the ventral forebrain. It is likely that Tes-1 plays a regulatory role in the development of this complex neural structure...
  20. ncbi Differential and overlapping expression domains of Dlx-2 and Dlx-3 suggest distinct roles for Distal-less homeobox genes in craniofacial development
    G W Robinson
    Laboratory of Mammalian Genes and Development, NICHD, National Institutes of Health, Bethesda, MD 20892
    Mech Dev 48:199-215. 1994
    ..The differential expression of Dlx genes in the branchial region suggests that they play key roles in craniofacial patterning and morphogenesis...
  21. ncbi Null mutation of Dlx-2 results in abnormal morphogenesis of proximal first and second branchial arch derivatives and abnormal differentiation in the forebrain
    M Qiu
    Nina Ireland Laboratory of Developmental Neurobiology, University of California at San Francisco 94143 0984, USA
    Genes Dev 9:2523-38. 1995
    ..These results show that Dlx-2 controls development of the branchial arches and the forebrain and suggests its role in craniofacial evolution...
  22. ncbi The mouse Dlx-2 (Tes-1) gene is expressed in spatially restricted domains of the forebrain, face and limbs in midgestation mouse embryos
    A Bulfone
    Department of Psychiatry, UCSF 94143
    Mech Dev 40:129-40. 1993
    ..Several mouse and human disorders have phenotypes which potentially are the result of mutations in the Dlx genes...
  23. ncbi Sequence, organization, and transcription of the Dlx-1 and Dlx-2 locus
    T McGuinness
    Nina Ireland Laboratory of Developmental Neurobiology, University of California, San Francisco 94143 0984, USA
    Genomics 35:473-85. 1996
    ..The sequence of the human Dlx-2 gene is reported and is compared to that of the murine gene. Finally, sequence analysis of the deduced protein sequences reveals several candidate functional domains...
  24. pmc Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism
    H Zhang
    Graduate Program in Microbiology and Molecular Genetics, UMDNJ Robert Wood Johnson Medical School, Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey 08854, USA
    Mol Cell Biol 17:2920-32. 1997
    ..Finally, we show that the expression patterns of representative Msx and Dlx genes (Msx1, Msx2, Dlx2, and Dlx5) overlap in mouse embryogenesis during limb bud and craniofacial development, consistent with the ..
  25. ncbi Role of the Dlx homeobox genes in proximodistal patterning of the branchial arches: mutations of Dlx-1, Dlx-2, and Dlx-1 and -2 alter morphogenesis of proximal skeletal and soft tissue structures derived from the first and second arches
    M Qiu
    Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, 94143 0984, USA
    Dev Biol 185:165-84. 1997
    ..Finally, the Dlx-2 and Dlx-1 and -2 mutants have ectopic skull components that resemble bones and cartilages found in phylogenetically more primitive vertebrates...
  26. ncbi Mutations of the homeobox genes Dlx-1 and Dlx-2 disrupt the striatal subventricular zone and differentiation of late born striatal neurons
    S A Anderson
    Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, 94143, USA
    Neuron 19:27-37. 1997
    ..Several lines of evidence suggest that mutations in Dlx-1 and Dlx-2 produce abnormalities in the development of the striatal subventricular zone and in the differentiation of striatal matrix neurons...
  27. ncbi Interneuron migration from basal forebrain to neocortex: dependence on Dlx genes
    S A Anderson
    Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, CA 94143 0984, USA
    Science 278:474-6. 1997
    ..Finally, mice lacking the homeodomain proteins DLX-1 and DLX-2 show no detectable cell migration from the subcortical telencephalon to the neocortex and also have few GABA-expressing cells in the neocortex...
  28. ncbi Signalling networks regulating dental development
    I Thesleff
    Institute of Biotechnology, University of Helsinki, Finland
    Mech Dev 67:111-23. 1997
    ....
  29. ncbi Dlx genes encode DNA-binding proteins that are expressed in an overlapping and sequential pattern during basal ganglia differentiation
    J K Liu
    Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, 94143 0984, USA
    Dev Dyn 210:498-512. 1997
    ..Antisense Dlx-1 and -6 have their highest expression in the SVZ. These results suggest that each of these Dlx genes may have a distinct role in different steps of differentiation in the basal ganglia...
  30. ncbi Patterning of the murine dentition by homeobox genes
    B L Thomas
    Department of Craniofacial Development, UMDS, Guy s Hospital, London, UK
    Eur J Oral Sci 106:48-54. 1998
    ..We propose that expression of these genes constitutes an odontogenic homeobox code which patterns the dentition...
  31. ncbi Expression and regulation of Lhx6 and Lhx7, a novel subfamily of LIM homeodomain encoding genes, suggests a role in mammalian head development
    M Grigoriou
    Division of Developmental Neurobiology, The National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 125:2063-74. 1998
    ..We suggest that Fgf8 and Lhx6 and Lhx7 are key components of signalling cascades which determine morphogenesis and differentiation in the first branchial arch and the basal forebrain...
  32. ncbi FGFs and BMP4 induce both Msx1-independent and Msx1-dependent signaling pathways in early tooth development
    M Bei
    Genetics Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Development 125:4325-33. 1998
    ..In addition, we have investigated the effects of FGFs and BMP4 on the distal-less homeobox genes Dlx1 and Dlx2 and we have clarified the relationship between Msx and Dlx gene function in the developing tooth...
  33. ncbi An olfactory sensory map develops in the absence of normal projection neurons or GABAergic interneurons
    A Bulfone
    Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California, San Francisco 94143 0984, USA
    Neuron 21:1273-82. 1998
    ..These observations suggest that the establishment of a topographic map is not dependent upon cues provided by, or synapse formation with, the major neuronal cell types in the olfactory bulb...
  34. ncbi Retinoids are produced by glia in the lateral ganglionic eminence and regulate striatal neuron differentiation
    H Toresson
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Division of Neurobiology, Section for Developmental Neurobiology, Lund University, Solvegatan 17, S 223 62 Lund, Sweden
    Development 126:1317-26. 1999
    ..These findings, therefore, strongly support the notion that local retinoid signalling within the lateral ganglionic eminence regulates striatal neuron differentiation...
  35. ncbi Teeth. Where and how to make them
    H Peters
    GSF Research Center for Environment and Health, Institute for Mammalian Genetics, Neuherberg, Germany
    Trends Genet 15:59-65. 1999
    ..This cascade provides a molecular model by which reciprocal tissue interactions are controlled...
  36. ncbi Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum
    L Sussel
    Center for Neurobiology and Psychiatry, Department of Psychiatry and University of California at San Francisco, CA 94143 0984, USA
    Development 126:3359-70. 1999
    ..TrkA-positive neurons (probable cholinergic neurons) and has reduced numbers of cortical cells expressing GABA, DLX2 and calbindin that migrate from the pallidum through the striatum and into the cortex...
  37. ncbi DLX-1, DLX-2, and DLX-5 expression define distinct stages of basal forebrain differentiation
    D D Eisenstat
    Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry and Programs in Neuroscience and Developmental Biology, University of California at San Francisco, California 94143 0984, USA
    J Comp Neurol 414:217-37. 1999
    ..In the basal telencephalon, these DLX-positive cells differentiate into projection neurons of the striatum and pallidum as well as interneurons, some of which migrate to the cerebral cortex and the olfactory bulb...
  38. pmc Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch
    A Trumpp
    G W Hooper Foundation, Department of Microbiology, School of Medicine, University of California at San Francisco UCSF, San Francisco, California 94143 0552, USA
    Genes Dev 13:3136-48. 1999
    ..Because the mutant mice resemble humans with first arch syndromes that include agnathia, our results raise the possibility that some of these syndromes are caused by mutations that affect FGF8 signaling in BA1 ectoderm...
  39. ncbi Temporospatial cell interactions regulating mandibular and maxillary arch patterning
    C A Ferguson
    Department of Craniofacial Development, GKT Dental Institute, Kings College, Guy s Hospital, London SE1 9RT, UK
    Development 127:403-12. 2000
    ..Thus, whereas both mandibular and maxillary arch epithelia could induce Dlx2 and Dlx5 expression in the mandible and Dlx2 expression in the maxilla, neither could induce Dlx5 expression in the ..
  40. ncbi A highly conserved enhancer in the Dlx5/Dlx6 intergenic region is the site of cross-regulatory interactions between Dlx genes in the embryonic forebrain
    T Zerucha
    Loeb Health Research Institute at the Ottawa Hospital and Department of Medicine, University of Ottawa, Ottawa, Ontario K1Y 4E9, Canada
    J Neurosci 20:709-21. 2000
    Four Dlx homeobox genes, Dlx1, Dlx2, Dlx5, and Dlx6 are expressed in the same primordia of the mouse forebrain with temporally overlapping patterns...
  41. ncbi Genetic control of dorsal-ventral identity in the telencephalon: opposing roles for Pax6 and Gsh2
    H Toresson
    Wallenberg Neuroscience Center, Division of Neurobiology, Section for Developmental Neurobiology, Lund University, Solvegatan 17, S 223 62 Lund, Sweden
    Development 127:4361-71. 2000
    ....
  42. ncbi The Gsh2 homeodomain gene controls multiple aspects of telencephalic development
    J G Corbin
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, NY 10016, USA
    Development 127:5007-20. 2000
    ..Taken together, our data support a model in which Gsh2, in response to sonic hedgehog signaling, plays a crucial role in multiple aspects of telencephalic development...
  43. ncbi Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalon
    K Yun
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, LPPI, University of California, San Francisco, Box 0984, San Francisco, CA 94143 0984, USA
    Development 128:193-205. 2001
    ..The role of Pax6 in dorsalizing the telencephalon is similar to its role in the spinal cord, supporting the hypothesis that some dorsoventral patterning mechanisms are used at all axial levels of the central nervous system...
  44. ncbi Distinct cortical migrations from the medial and lateral ganglionic eminences
    S A Anderson
    Nina Ireland Laboratory of Developmental Neuroscience, Department of Psychiatry, University of California, San Francisco, CA 94143 0984, USA
    Development 128:353-63. 2001
    ..In addition, by comparing the phenotypes of mouse mutants with differential effects on MGE and LGE migration, we provide evidence that the MGE and LGE may give rise to different subtypes of cortical interneurons...
  45. ncbi Cell migration from the ganglionic eminences is required for the development of hippocampal GABAergic interneurons
    S J Pleasure
    Neurodevelopmental Disorders Laboratory, Department of Neurology, University of California, San Francisco, CA 94143, USA
    Neuron 28:727-40. 2000
    ..Loss of hippocampal interneurons does not appear to have major effects on the early development of hippocampal projection neurons nor on the pathfinding of afferrent tracts...
  46. ncbi LIM-homeodomain gene Lhx2 regulates the formation of the cortical hem
    S Bulchand
    Department of Biological Sciences, Tata Institute of Fundamental Research, 400005, Mumbai, India
    Mech Dev 100:165-75. 2001
    ..The defect in the Lhx2-/- telencephalon appears to be at this step...
  47. ncbi Sorting of striatal and cortical interneurons regulated by semaphorin-neuropilin interactions
    O Marin
    Department of Psychiatry, Nina Ireland Laboratory of Developmental Neurobiology, Langley Porter Psychiatric Institute, University of California, San Francisco, CA 94143, USA
    Science 293:872-5. 2001
    ....
  48. ncbi Ectopic expression of the Dlx genes induces glutamic acid decarboxylase and Dlx expression
    Thorsten Stühmer
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, LPPI, University of California at San Francisco, 401 Parnassus Avenue, San Francisco, CA 94143 0984, USA
    Development 129:245-52. 2002
    ..This approach showed that ectopic expression of Dlx2 and Dlx5 induced the expression of glutamic acid decarboxylases (GADs), the enzymes that synthesize GABA...
  49. ncbi Specification of jaw subdivisions by Dlx genes
    Michael J Depew
    Nina Ireland Laboratory of Developmental Neurobiology, 401 Parnassus Avenue, University of California, San Francisco, San Francisco, CA 94143 0984, USA
    Science 298:381-5. 2002
    ..We suggest that nested Dlx expression in the arches patterns their proximodistal axes. Evolutionary acquisition and subsequent refinement of jaws may have been dependent on modification of Dlx expression...
  50. ncbi Fgf8 is required for pharyngeal arch and cardiovascular development in the mouse
    Radwan Abu-Issa
    Department of Pediatrics, Neonatal Perinatal Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    Development 129:4613-25. 2002
    ..This study defines the cardiovascular defects present in Fgf8 mutants and supports a role for Fgf8 in development of all the pharyngeal arches and in NCC survival...
  51. ncbi The caudal ganglionic eminence is a source of distinct cortical and subcortical cell populations
    Susana Nery
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, New York 10016, USA
    Nat Neurosci 5:1279-87. 2002
    ..Moreover, we report that the migratory fate of cells from the CGE is intrinsically determined by embryonic day 13.5 (E13.5). Together, these results provide the first insights into the development and fate of the CGE...
  52. ncbi Identification of two distinct progenitor populations in the lateral ganglionic eminence: implications for striatal and olfactory bulb neurogenesis
    Jan Stenman
    Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, Ohio 45229 3039, USA
    J Neurosci 23:167-74. 2003
    ..In support of this, mice mutant for the homeobox genes Gsh2 and Gsh1/2, which show olfactory bulb defects, exhibit dramatically reduced numbers of Er81-positive cells in the LGE SVZ as well as in the olfactory bulb mantle...
  53. ncbi Directional guidance of interneuron migration to the cerebral cortex relies on subcortical Slit1/2-independent repulsion and cortical attraction
    Oscar Marin
    Department of Psychiatry, Nina Ireland Laboratory of Developmental Neurobiology, Langley Porter Psychiatric Institute, 401 Parnassus Avenue, University of California San Francisco, CA 94143, USA
    Development 130:1889-901. 2003
    ....
  54. ncbi Dlx-1 and Dlx-2 expression in the adult mouse brain: relationship to dopaminergic phenotypic regulation
    Sachiko Saino-Saito
    Weill Medical College of Cornell University at The Burke Medical Research Institute, White Plains, New York 10605, USA
    J Comp Neurol 461:18-30. 2003
    ..The widespread expression of Dlx mRNA and protein in the adult brain suggests that these genes may have additional roles in mature animals...
  55. ncbi Dlx1, Dlx2, Pax6, Brn3b, and Chx10 homeobox gene expression defines the retinal ganglion and inner nuclear layers of the developing and adult mouse retina
    Jimmy de Melo
    Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba R3E 0V9, Canada
    J Comp Neurol 461:187-204. 2003
    ..We assessed Dlx gene expression in the developing and adult mouse retina. Dlx1 and Dlx2 are detected in retinal neuroprogenitors by embryonic day (E) 12.5 (Eisenstat et al. [1999] J. Comp. Neurol...
  56. ncbi Identification of a Pax6-dependent epidermal growth factor family signaling source at the lateral edge of the embryonic cerebral cortex
    Stavroula Assimacopoulos
    Department of Neurobiology, Pharmacology, and Physiology, The University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 23:6399-403. 2003
    ..We find that the antihem is lost in mice homozygous for the Small eye (Pax6) mutation and suggest the loss of EGF signaling at least partially explains defects in cortical patterning and cell migration in Small eye mice...
  57. ncbi Paleocortex is specified in mice in which dorsal telencephalic patterning is severely disrupted
    Aditee Vyas
    Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India
    J Comp Neurol 466:545-53. 2003
    ..Furthermore, our in vitro data reveal that, if mechanisms outside the lateral telencephalon are involved in the specification of the paleocortex, they must act extremely early, prior to E10.5...
  58. pmc Identification of a direct Dlx homeodomain target in the developing mouse forebrain and retina by optimization of chromatin immunoprecipitation
    Qing Ping Zhou
    Manitoba Institute of Cell Biology, 675 McDermot Avenue, Winnipeg, Manitoba, Canada
    Nucleic Acids Res 32:884-92. 2004
    ..Dlx genes are expressed in the developing forebrain, retina, craniofacial structures and limbs. Dlx1/Dlx2 double knockout mice die at birth with multiple defects including abnormal forebrain development and decreased Dlx5 ..
  59. ncbi Origins of cortical interneuron subtypes
    Qing Xu
    Department of Psychiatry, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 24:2612-22. 2004
    ..By establishing spatial differences in the origins of interneuron subtypes, these studies lay the groundwork for elucidating the molecular bases for their distinct differentiation pathways...
  60. pmc Endothelin-A receptor-dependent and -independent signaling pathways in establishing mandibular identity
    Louis Bruno Ruest
    Department of Molecular, Cellular and Craniofacial Biology and the Birth Defects Center, University of Louisville, Louisville, KY 40292, USA
    Development 131:4413-23. 2004
    ..Together, our results suggest that the establishment of a 'mandibular identity' during lower jaw development requires both Ednra-dependent and -independent signaling pathways...
  61. ncbi Mouse orthologue of ARX, a gene mutated in several X-linked forms of mental retardation and epilepsy, is a marker of adult neural stem cells and forebrain GABAergic neurons
    Elena Colombo
    Stem Cell Research Institute, DIBIT, San Raffaele Science Park, Via Olgettina 58, 20132 Milan, Italy
    Dev Dyn 231:631-9. 2004
    ..and is enhanced during differentiation of the subpallial structures of the ganglionic eminences, overlapping with Dlx2, Dlx5, and Gad1 transcriptional domains...
  62. ncbi The vertebrate ortholog of Aristaless is regulated by Dlx genes in the developing forebrain
    Inma Cobos
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, San Francisco, California 94158 2611, USA
    J Comp Neurol 483:292-303. 2005
    ..Therefore, our results suggest evolutionarily conserved functions of Dlx genes in regulating Arx expression between Drosophila and vertebrates...
  63. ncbi Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy
    Inma Cobos
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California San Francisco, San Francisco, California 94158, USA
    Nat Neurosci 8:1059-68. 2005
    ..Dlx1 mutant mice show generalized electrographic seizures and histological evidence of seizure-induced reorganization, linking the Dlx1 mutation to delayed-onset epilepsy associated with interneuron loss...
  64. pmc The Evf-2 noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator
    Jianchi Feng
    Program in Neurobiology and Department of Pediatrics, Children s Memorial Hospital and Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60614, USA
    Genes Dev 20:1470-84. 2006
    ....
  65. ncbi Necdin promotes GABAergic neuron differentiation in cooperation with Dlx homeodomain proteins
    Takaaki Kuwajima
    Laboratory of Regulation of Neuronal Development, Institute for Protein Research, Osaka University, Suita, Osaka 565 0871, Japan
    J Neurosci 26:5383-92. 2006
    ..Immunohistochemical analysis revealed that necdin was coexpressed with Dlx2, Dlx5, or MAGE-D1 in a subpopulation of embryonic forebrain cells...
  66. ncbi Cellular patterns of transcription factor expression in developing cortical interneurons
    Inma Cobos
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California at San Francisco, San Francisco, CA 94158 2611, USA
    Cereb Cortex 16:i82-8. 2006
    ..in differentiating and mature neocortical interneurons of 8 transcription factors, including 6 homeobox (Dlx1, Dlx2, Dlx5, Arx, Lhx6, Cux2), 1 basic helix-loop-helix, (NPAS1), and 1 bZIP (MafB)...
  67. ncbi Generation of GABAergic and dopaminergic interneurons from endogenous embryonic olfactory bulb precursor cells
    Eva Vergaño-Vera
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas CSIC, Spain
    Development 133:4367-79. 2006
    ..olfactory bulb (OB) interneurons arise in the lateral ganglionic eminence (LGE) from precursor cells expressing Dlx2, Gsh2 and Er81 transcription factors...
  68. ncbi Cell migration along the lateral cortical stream to the developing basal telencephalic limbic system
    Rosalind S E Carney
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA
    J Neurosci 26:11562-74. 2006
    ..We reveal that Pax6 (paired box gene 6)-positive pallial-derived and Dlx2 (distal-less homeobox 2)-positive subpallial-derived subpopulations of LCS cells are generated in distinct temporal ..
  69. ncbi Dlx homeobox genes promote cortical interneuron migration from the basal forebrain by direct repression of the semaphorin receptor neuropilin-2
    Trung N Le
    Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba R3E 0V9, Canada
    J Biol Chem 282:19071-81. 2007
    Dlx homeobox genes play an important role in vertebrate forebrain development. Dlx1/Dlx2 null mice die at birth with an abnormal cortical phenotype, including impaired differentiation and migration of GABAergic interneurons to the ..
  70. ncbi The proneural determinant MASH1 regulates forebrain Dlx1/2 expression through the I12b intergenic enhancer
    Luc Poitras
    Center for Advanced Research in Environmental Genomics CAREG Department of Biology, University of Ottawa, Ottawa, Ontario, Canada
    Development 134:1755-65. 2007
    ..In the developing forebrain of mammals, the combined function of the Dlx1, Dlx2, Dlx5 and Dlx6 homeobox genes is necessary for the differentiation of the GABAergic interneurons born in the ..
  71. pmc A subpopulation of olfactory bulb GABAergic interneurons is derived from Emx1- and Dlx5/6-expressing progenitors
    Minoree Kohwi
    Department of Neurosurgery, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 27:6878-91. 2007
    ..A subset of Dlx2+ OB interneurons was derived from cells expressing Emx1, a transcription factor largely restricted to the pallium ..
  72. pmc Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codes
    Nuria Flames
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
    J Neurosci 27:9682-95. 2007
    ..Furthermore, the results of microtransplantation experiments in vivo corroborate that anatomically defined regions of the mouse subpallium, such as the medial ganglionic eminence, can be subdivided into functionally distinct domains...
  73. doi Enhanced BMP signaling results in supernumerary tooth formation in USAG-1 deficient mouse
    Akiko Murashima-Suginami
    Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Biochem Biophys Res Commun 369:1012-6. 2008
    ..BMP signaling in the rudimentary maxillary incisor, assessed by expressions of Msx1 and Dlx2 and the phosphorylation of Smad protein, was significantly enhanced...
  74. pmc A dlx2- and pax6-dependent transcriptional code for periglomerular neuron specification in the adult olfactory bulb
    Monika S Brill
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, D 80336 Munich, Germany
    J Neurosci 28:6439-52. 2008
    ..Here we show that in the adult brain, Dlx 1 and Dlx2 are expressed in progenitors of the lateral but not the dorsal subependymal zone (SEZ), thus exhibiting a striking ..
  75. pmc Differential regulation of telencephalic pallial-subpallial boundary patterning by Pax6 and Gsh2
    Rosalind S E Carney
    Center for Neuroscience Research, Children s Research Institute, Children s National Medical Center, Washington, DC 20010, USA
    Cereb Cortex 19:745-59. 2009
    ..Thus, in addition to their well-characterized cross-repressive roles in dorsal/ventral patterning our analyses reveal important novel functions of Gsh2 and Pax6 in the regulation of PSB progenitor pool specification and patterning...
  76. pmc An endothelin-1 switch specifies maxillomandibular identity
    Takahiro Sato
    Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 105:18806-11. 2008
    ..Also, we show that, within PA1, CNCCs are competent to form both mandibular and maxillary structures and that an Edn1 switch is responsible for the choice of either morphogenetic program...
  77. pmc Generation of Cre-transgenic mice using Dlx1/Dlx2 enhancers and their characterization in GABAergic interneurons
    Gregory B Potter
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California at San Francisco, San Francisco, CA 94158 2611, USA
    Mol Cell Neurosci 40:167-86. 2009
    DLX1 and DLX2 transcription factors are necessary for forebrain GABAergic neuron differentiation, migration, and survival...
  78. pmc The neural crest-enriched microRNA miR-452 regulates epithelial-mesenchymal signaling in the first pharyngeal arch
    Neil T Sheehy
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Development 137:4307-16. 2010
    ..Dicer mutant embryos had reduced expression of Dlx2, a transcriptional regulator of pharyngeal arch development, in the first pharyngeal arch (PA1)...
  79. pmc Ectodermal-derived Endothelin1 is required for patterning the distal and intermediate domains of the mouse mandibular arch
    André L P Tavares
    Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
    Dev Biol 371:47-56. 2012
    ..Together, our results illustrate an integral role for ectoderm-derived Edn1 in early arch morphogenesis, particularly in the intermediate domain...
  80. doi Pattern and polarity in the development and evolution of the gnathostome jaw: both conservation and heterotopy in the branchial arches of the shark, Scyliorhinus canicula
    Claudia Compagnucci
    Department of Craniofacial Development, King s College London, Floor 27, Guy s Hospital, London Bridge, London SE1 9RT, UK
    Dev Biol 377:428-48. 2013
    ....
  81. ncbi The spatial localization of Dlx-2 during tooth development
    B L Thomas
    Department of Craniofacial Development, UMDS, Guy s Hospital, London, U K
    Connect Tissue Res 32:27-34. 1995
    ..This localization shows a number of similarities with the expression of Msx-2 and suggests a role for Dlx-2 in tooth initiation and tissue patterning...
  82. ncbi Pax6 regulates the identity of embryonic diencephalic neurons
    G S Mastick
    Department of Biology, University of Nevada, Reno, Nevada 89557, USA
    Mol Cell Neurosci 17:190-207. 2001
    ..Pax6 up-regulation occurred only several hours postdifferentiation. The loss of Pax6 altered progenitor specification, and the Lhx1 neuronal marker was lost, indicating a role for Pax6 in the specification of forebrain neuron identity...
  83. ncbi Evidence that GRIP, a PDZ-domain protein which is expressed in the embryonic forebrain, co-activates transcription with DLX homeodomain proteins
    G Yu
    Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry, 401 Parnassus Avenue, University of California at San Francisco, CA 94143 0984, USA
    Brain Res Dev Brain Res 130:217-30. 2001
    ..the yeast two-hybrid assay, and found a DLX interacting protein (DIP2) which binds to the N-terminal region of DLX2 via a PDZ domain...
  84. ncbi A role for the mesenchymal T-box gene Brachyury in AER formation during limb development
    Chunqiao Liu
    Laboratory of Pathology, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA
    Development 130:1327-37. 2003
    ....
  85. ncbi Mesenchymal patterning by Hoxa2 requires blocking Fgf-dependent activation of Ptx1
    Nicoletta Bobola
    Department of Developmental Biology, Max Planck Institute of Immunobiology, Freiburg, Germany
    Development 130:3403-14. 2003
    ....
  86. ncbi Functional equivalence of Brn3 POU-domain transcription factors in mouse retinal neurogenesis
    Ling Pan
    Center for Aging and Developmental Biology, University of Rochester, Rochester, NY 14642, USA
    Development 132:703-12. 2005
    ..These results indicate that Brn3 factors are functionally equal and that their unique roles in neurogenesis are determined by the distinctive Brn3 spatiotemporal expression patterns...
  87. pmc A comprehensive negative regulatory program controlled by Brn3b to ensure ganglion cell specification from multipotential retinal precursors
    Feng Qiu
    Center for Advanced Biotechnology and Medicine and Department of Pediatrics, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
    J Neurosci 28:3392-403. 2008
    ..Our data suggest that Brn3b specifies the RGC fate from multipotential precursors not only by promoting RGC differentiation but also by suppressing non-RGC differentiation programs as a safeguard mechanism...
  88. doi Ptch1-mediated dosage-dependent action of Shh signaling regulates neural progenitor development at late gestational stages
    Yayoi Shikata
    Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Dev Biol 349:147-59. 2011
    ..These data indicated that endogenous Ptch1 mediates the broad effects of Shh on the transition from VZ progenitors to IPCs and activation of proliferation of the IPCs in the cortex during late gestational stages...
  89. pmc The Wnt receptor Ryk controls specification of GABAergic neurons versus oligodendrocytes during telencephalon development
    Jingyang Zhong
    The Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Development 138:409-19. 2011
    ..of the intrinsic oligodendrogenic factor Olig2 while inducing expression of the interneuron fate determinant Dlx2. In addition, we demonstrate that Ryk is required for GABAergic neuron induction and oligodendrogenesis inhibition ..
  90. doi Wnt5a is a transcriptional target of Dlx homeogenes and promotes differentiation of interneuron progenitors in vitro and in vivo
    Sara Paina
    Dulbecco Telethon Institute c o Molecular Biotechnology Center, University of Torino, 10126 Torino, Italy
    J Neurosci 31:2675-87. 2011
    ..b>Dlx2 and Dlx5 interact with homeodomain binding sequences within the Wnt5a locus and activate its transcription...
  91. pmc Sprouty genes are essential for the normal development of epibranchial ganglia in the mouse embryo
    Subreena Simrick
    Department of Craniofacial Development, King s College London, Floor 27, Guy s Tower, London, SE1 9RT, UK
    Dev Biol 358:147-55. 2011
    ....
  92. ncbi Order of six loci at 2q24-q31 and orientation of the HOXD locus
    E Rossi
    Universita di Pavia, Italy
    Genomics 24:34-40. 1994
    ..9 homeobox genes of the Antennapedia class; EVX2, a homeobox gene related to Drosophila-even-skipped gene; DLX1 and DLX2, two homeobox genes related to the Drosophila distal-less gene; and TTN and NEB, the genes for the two giant ..
  93. ncbi Fetal brain subdivisions defined by R- and E-cadherin expressions: evidence for the role of cadherin activity in region-specific, cell-cell adhesion
    H Matsunami
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    Dev Biol 172:466-78. 1995
    ..These results suggest that cadherins confer region-specific adhesiveness on fetal brain cells and that this process may take part in brain segmentation...
  94. pmc Genetic and physical mapping of the mouse Ulnaless locus
    C L Peichel
    Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Genetics 144:1757-67. 1996
    ..Therefore, the region that must contain the Ulnaless locus has been defined and cloned, which will be invaluable for the identification of the molecular nature of the Ulnaless mutation...
  95. ncbi Analysis of the genetic pathway leading to formation of ectopic apical ectodermal ridges in mouse Engrailed-1 mutant limbs
    C A Loomis
    Ronald O Perelman Department of Dermatology, NYU Medical School, New York, NY 10016, USA
    Development 125:1137-48. 1998
    ..This leads to induction of a second zone of compaction ventrally, which in some cases goes on to form an autonomous secondary AER...
  96. ncbi The loss of ventral ectoderm identity correlates with the inability to form an AER in the legless hindlimb bud
    S M Bell
    Division of Developmental Biology Children s Hospital Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Mech Dev 74:41-50. 1998
    ..These data suggest that establishment of a dorso-ventral ectodermal interface is not sufficient for AER formation and that restriction of lmx-1b to the dorsal mesenchyme is coordinately linked to AER formation...
  97. ncbi Mice mutant for both Hoxa1 and Hoxb1 show extensive remodeling of the hindbrain and defects in craniofacial development
    M Rossel
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    Development 126:5027-40. 1999
    ....
  98. ncbi Dorsoventral patterning of the telencephalon is disrupted in the mouse mutant extra-toes(J)
    S Tole
    Department of Neurobiology, University of Chicago, Chicago, Illinois, 60637, USA
    Dev Biol 217:254-65. 2000
    ..Our findings suggest that in dorsal telencephalon Gli3 is needed to repress ventral telencephalic identity...
  99. ncbi Lhx9 and Lhx9alpha LIM-homeodomain factors: genomic structure, expression patterns, chromosomal localization, and phylogenetic analysis
    V Failli
    Laboratoire de Neurochimie Anatomie, Institut des Neurosciences, 9 Quai St Bernard, Paris, 75005, France
    Genomics 64:307-17. 2000
    ..We suggest that Lhx9alpha could function as an endogenous dominant-negative form of Lhx9 during development, both to regulate in space and time the transcriptional effects of Lhx9 and to add a degree of refinement to the LIM-hd code...
  100. pmc The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development
    Raymond F Robledo
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Genes Dev 16:1089-101. 2002
    ..Furthermore, spatiotemporal-specific transgenic overexpression of Dlx5, in the apical ectodermal ridge of Dlx5/6 null mice can fully rescue Dlx/Dll function in limb outgrowth...
  101. ncbi BMP signaling is required locally to pattern the dorsal telencephalic midline
    Jean M Hebert
    Department of Biological Sciences, Stanford University, 385 Serra Mall, CA 94305, USA
    Neuron 35:1029-41. 2002
    ..Our data fail to support a more global, concentration-dependent role in specifying telencephalic cell fates...

Research Grants5

  1. PIONEER AXON GUIDANCE IN THE EMBRYONIC FOREBRAIN
    GRANT MASTICK; Fiscal Year: 2004
    ..In addition, the mechanisms of axon growth during development may give insight into how regeneration of the nervous system may be stimulated following trauma or disease. ..
  2. Regulation of Laminar Fate in Cerebral Cortex
    Robert Hevner; Fiscal Year: 2006
    ..If molecular fates are aEered in heterochronic or Rein mutant cortex, this would suggest that certain aspects of laminar fate can be regulated post-mitotically. ..
  3. MECHANISMS OF NEURAL PATTERNING IN MAMMALIAN FOREBRAIN
    Gordon Fishell; Fiscal Year: 2007
    ..abstract_text> ..
  4. REGIONAL PATTERNING IN THE VENTRAL TELENCEPHALON
    GORDON J FISHELL; Fiscal Year: 2010
    ..If we can understand how this population is generated, we will take the first step towards assessing whether we can use gene or cell therapies to ameliorate the devasting consequences associated with cortical interneuron dysfunction. ..
  5. Longitudinal axon guidance by long range cues in the embryonic brain
    GRANT STEPHEN MASTICK; Fiscal Year: 2011
    ....