Dnmt3b

Summary

Gene Symbol: Dnmt3b
Description: DNA methyltransferase 3B
Alias: MmuIIIB, DNA (cytosine-5)-methyltransferase 3B, DNA MTase MmuIIIB, DNA methyltransferase MmuIIIB
Species: mouse

Top Publications

  1. ncbi Genomic organization and promoter analysis of the Dnmt3b gene
    Chisaki Ishida
    Division of Gene Therapy Science, Osaka University School of Medicine, 2 2 Yamada oka, Suita, 565 0870, Osaka, Japan
    Gene 310:151-9. 2003
  2. ncbi The orphan nuclear receptor GCNF recruits DNA methyltransferase for Oct-3/4 silencing
    Noriko Sato
    Cytokine Project, The Tokyo Metropolitan Institute of Medical Science, 3 18 22 Honkomagome, Bunkyo ku, Tokyo 113 8613, Japan
    Biochem Biophys Res Commun 344:845-51. 2006
  3. doi Suppressing effects of down-regulating DNMT1 and DNMT3b expression on the growth of human cholangiocarcinoma cell line
    Shi Zuo
    Department of General Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    J Huazhong Univ Sci Technolog Med Sci 28:276-80. 2008
  4. ncbi Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases
    M Okano
    Nat Genet 19:219-20. 1998
  5. ncbi DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
    M Okano
    Cardiovascular Research Center, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Charlestown 02129, USA
    Cell 99:247-57. 1999
  6. ncbi Molecular enzymology of the catalytic domains of the Dnmt3a and Dnmt3b DNA methyltransferases
    Humaira Gowher
    Institut fur Biochemie, FB 8, Justus Liebig Universitat, Heinrich Buff Ring 58, 35392 Giessen, Germany
    J Biol Chem 277:20409-14. 2002
  7. ncbi Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice
    Kenichiro Hata
    Cardiovascular Research Center, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Development 129:1983-93. 2002
  8. ncbi A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation
    Taiping Chen
    Cardiovascular Research Center, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Biol Chem 277:38746-54. 2002
  9. ncbi Stage- and cell-specific expression of Dnmt3a and Dnmt3b during embryogenesis
    Daisuke Watanabe
    Institute of Molecular and Cellular Biology, Osaka University, 1 3 Yamadaoka, Suita, Japan
    Mech Dev 118:187-90. 2002
  10. pmc DNA methylation density influences the stability of an epigenetic imprint and Dnmt3a/b-independent de novo methylation
    Matthew C Lorincz
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Mol Cell Biol 22:7572-80. 2002

Scientific Experts

  • Sarmila Majumder
  • Andrea Fuso
  • BRUCE KONE
  • Sangkyu Park
  • Miguel Vidal
  • Ryutaro Hirasawa
  • Steven K Huang
  • R Scott Hansen
  • Lin Liu
  • Bin Liu
  • D Watanabe
  • Vitalyi Senyuk
  • Shuji Takada
  • Shi Zuo
  • Diana Lucifero
  • M Okano
  • Noriko Sato
  • En Li
  • Taiping Chen
  • Hiroyuki Sasaki
  • Kenichiro Hata
  • Isao Suetake
  • Sichuan Xi
  • Humaira Gowher
  • Shoji Tajima
  • Theresa M Geiman
  • Rudolf Jaenisch
  • Albert Jeltsch
  • Yoshihide Ueda
  • Guo Liang Xu
  • Masahiro Kaneda
  • Masahiro Oka
  • Sophie La Salle
  • Eveline J Steine
  • Hatsune Chiba
  • Jafar Sharif
  • Heinz G Linhart
  • Yuzuru Kato
  • Kathrin Muegge
  • Isabel Jaco
  • Maria A Blasco
  • Bernard Ramsahoye
  • Jessica Margaret Sido
  • Hitomi Matsuzaki
  • Hiroaki Fujimori
  • Yong Liu
  • Jing Liao
  • Shay Geula
  • Haijiang Lin
  • Heming Zhu
  • Nick Gilbert
  • Francesco Neri
  • Seung Min Yang
  • Mounia Guenatri
  • Matthew C Lorincz
  • Ryan A Hlady
  • Toru Nakano
  • Ik Soo Kim
  • Qing Yu
  • Kaori Hisada
  • Chun Chang Chen
  • Naomi Tsujimoto
  • Jonathan E Dodge
  • Igor O Nasonkin
  • Mohammad M Karimi
  • Mathias Pawlak
  • Alexander Meissner
  • Julie Borgel
  • Katan Patel
  • Judith K Christman
  • Biao Hu
  • Li Shen
  • Guillaume Velasco
  • Mrinal Y Shah
  • Takaho A Endo
  • Haruhiko Koseki
  • Yoichi Shinkai
  • Evani Viegas-Péquignot
  • Girdhari Lal
  • Norio Nakatsuji
  • Daniela Meilinger
  • Masanobu Shoji
  • Shinichiro Chuma
  • Mathias Ehrich
  • Mi Sun Kim
  • Seiji Takashima
  • Suhasni Gopalakrishnan
  • Andreas May
  • Ye Guang Hu
  • Hong Xu

Detail Information

Publications105 found, 100 shown here

  1. ncbi Genomic organization and promoter analysis of the Dnmt3b gene
    Chisaki Ishida
    Division of Gene Therapy Science, Osaka University School of Medicine, 2 2 Yamada oka, Suita, 565 0870, Osaka, Japan
    Gene 310:151-9. 2003
    The Dnmt3b gene encodes a de novo DNA methyltransferase that is essential for normal mouse development. It is highly expressed in early embryos and embryonic stem (ES) cells but downregulated in most adult somatic tissues...
  2. ncbi The orphan nuclear receptor GCNF recruits DNA methyltransferase for Oct-3/4 silencing
    Noriko Sato
    Cytokine Project, The Tokyo Metropolitan Institute of Medical Science, 3 18 22 Honkomagome, Bunkyo ku, Tokyo 113 8613, Japan
    Biochem Biophys Res Commun 344:845-51. 2006
    ..Our finding suggests a model in which differentiation-induced GCNF recruits de novo DNA methyltransferase and facilitates the silencing of a pluripotency gene...
  3. doi Suppressing effects of down-regulating DNMT1 and DNMT3b expression on the growth of human cholangiocarcinoma cell line
    Shi Zuo
    Department of General Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    J Huazhong Univ Sci Technolog Med Sci 28:276-80. 2008
    ..In order to explore the roles of two methyltransferase members (DNMT1 and DNMT3b) in the cholangiocarcinoma tumorigenesis, antisense eukaryotic expression plasmid of DNMT1 and DNMT3b gene was ..
  4. ncbi Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases
    M Okano
    Nat Genet 19:219-20. 1998
  5. ncbi DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
    M Okano
    Cardiovascular Research Center, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Charlestown 02129, USA
    Cell 99:247-57. 1999
    ..Here we demonstrate that two recently identified DNA methyltransferases, Dnmt3a and Dnmt3b, are essential for de novo methylation and for mouse development...
  6. ncbi Molecular enzymology of the catalytic domains of the Dnmt3a and Dnmt3b DNA methyltransferases
    Humaira Gowher
    Institut fur Biochemie, FB 8, Justus Liebig Universitat, Heinrich Buff Ring 58, 35392 Giessen, Germany
    J Biol Chem 277:20409-14. 2002
    The C-terminal domains of the mammalian DNA methyltransferases Dnmt1, Dnmt3a, and Dnmt3b harbor all the conserved motifs characteristic for cytosine-C5 methyltransferases...
  7. ncbi Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice
    Kenichiro Hata
    Cardiovascular Research Center, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Development 129:1983-93. 2002
    ..In this study, we demonstrate that Dnmt3L, a protein sharing homology with DNA methyltransferases, Dnmt3a and Dnmt3b, but lacking enzymatic activity, is essential for the establishment of maternal methylation imprints and ..
  8. ncbi A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation
    Taiping Chen
    Cardiovascular Research Center, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Biol Chem 277:38746-54. 2002
    Previous studies have shown that the Dnmt3b gene encodes multiple variants via alternative splicing. However, only one form of Dnmt3a has been identified to date...
  9. ncbi Stage- and cell-specific expression of Dnmt3a and Dnmt3b during embryogenesis
    Daisuke Watanabe
    Institute of Molecular and Cellular Biology, Osaka University, 1 3 Yamadaoka, Suita, Japan
    Mech Dev 118:187-90. 2002
    DNA methylation is essential for development. Two DNA methyltransferases, Dnmt3a and Dnmt3b, contribute to the creation of DNA methylation patterns in embryos...
  10. pmc DNA methylation density influences the stability of an epigenetic imprint and Dnmt3a/b-independent de novo methylation
    Matthew C Lorincz
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Mol Cell Biol 22:7572-80. 2002
    ..The DNA methyltransferases (MTases) Dnmt3a and Dnmt3b are thought to be the sole de novo MTases in the mammalian genome...
  11. ncbi Distinct enzymatic properties of recombinant mouse DNA methyltransferases Dnmt3a and Dnmt3b
    Isao Suetake
    Institute for Protein Research, Osaka University, 3 2 Yamadaoka, Suita, Osaka 565 0871
    J Biochem 133:737-44. 2003
    Recombinant mouse Dnmt3a and Dnmt3b were expressed in sf9 cells and purified to near homogeneity. The purified Dnmt3a and Dnmt3b gave specific activities of 1.8 +/- 0.3 and 1.3 +/- 0...
  12. pmc Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b
    Taiping Chen
    Cutaneous Biology Research Center and Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Mol Cell Biol 23:5594-605. 2003
    We have previously shown that the DNA methyltransferases Dnmt3a and Dnmt3b carry out de novo methylation of the mouse genome during early postimplantation development and of maternally imprinted genes in the oocyte...
  13. ncbi Gene-specific timing and epigenetic memory in oocyte imprinting
    Diana Lucifero
    McGill University, Montreal Children s Hospital Research Institute and Departments of Pediatrics, Human Genetics and Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada H3H 1P3
    Hum Mol Genet 13:839-49. 2004
    ..methylation acquisition was probably related to oocyte diameter and coincided with the accumulation of Dnmt3a, Dnmt3b and Dnmt3L transcripts...
  14. ncbi Windows for sex-specific methylation marked by DNA methyltransferase expression profiles in mouse germ cells
    Sophie La Salle
    Department of Pharmacology and Therapeutics and The Montreal Children s Hospital Research Institute, McGill University, Montreal, QC, Canada H3H 1P3
    Dev Biol 268:403-15. 2004
    ..We compared the temporal expression patterns of the DNA methyltransferases, DNMT1, DNMT3a, DNMT3b, and DNMT3l in the male and female germ lines...
  15. ncbi DNMT3B interacts with hSNF2H chromatin remodeling enzyme, HDACs 1 and 2, and components of the histone methylation system
    Theresa M Geiman
    Epigenetic Gene Regulation and Cancer Section, LRBGE NCI NIH, Bldg 41, Rm C306, 41 Library Dr, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 318:544-55. 2004
    ..De novo DNA methyltransferase DNMT3B is critical for embryonic development and is mutated in ICF syndrome...
  16. ncbi Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting
    Masahiro Kaneda
    Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Research Organization of Information and Systems, Mishima 411 8540, Japan
    Nature 429:900-3. 2004
    ..novo DNA methyltransferases of the Dnmt3 family are implicated in maternal imprinting, the lethality of Dnmt3a and Dnmt3b knockout mice has precluded further studies...
  17. pmc Severe global DNA hypomethylation blocks differentiation and induces histone hyperacetylation in embryonic stem cells
    Melany Jackson
    John Hughes Bennett Laboratory, Division of Oncology, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
    Mol Cell Biol 24:8862-71. 2004
    ..This demonstrates that successful terminal differentiation is not dependent simply on adequate methylation levels. There is an absolute requirement that the methylation be delivered by the maintenance enzyme Dnmt1...
  18. pmc The PWWP domain of Dnmt3a and Dnmt3b is required for directing DNA methylation to the major satellite repeats at pericentric heterochromatin
    Taiping Chen
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    Mol Cell Biol 24:9048-58. 2004
    Dnmt3a and Dnmt3b are responsible for the establishment of DNA methylation patterns during development...
  19. ncbi Expression of Dnmt3b in mouse hematopoietic progenitor cells and spermatogonia at specific stages
    Daisuke Watanabe
    Molecular Embryology, Department of Bioscience, Kitasato University, 1 15 1 Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    Gene Expr Patterns 5:43-9. 2004
    Two de novo-type DNA methyltransferases, Dnmt3a and Dnmt3b, are responsible for the creation of DNA methylation patterns during development...
  20. ncbi Co-expression of de novo DNA methyltransferases Dnmt3a2 and Dnmt3L in gonocytes of mouse embryos
    Yasuhiro Sakai
    Department of Anatomy, Kitasato University School of Medicine, Sagamihara 228 8555, Japan
    Gene Expr Patterns 5:231-7. 2004
    ..In the present study, we examined which de novo-type DNA methyltransferase, Dnmt3a, Dnmt3a2 or Dnmt3b is expressed in gonocytes at these stages...
  21. pmc Myc represses transcription through recruitment of DNA methyltransferase corepressor
    Carmen Brenner
    Free University of Brussels, Faculty of Medicine, Laboratory of Molecular Virology, Brussels, Belgium
    EMBO J 24:336-46. 2005
    ..Furthermore, these findings suggest that targeting of DNA methyltransferases by transcription factors is a wide and general mechanism for the generation of specific DNA methylation patterns within a cell...
  22. ncbi Mechanism of stimulation of catalytic activity of Dnmt3A and Dnmt3B DNA-(cytosine-C5)-methyltransferases by Dnmt3L
    Humaira Gowher
    International University Bremen, School of Engineering and Science, Campus Ring 1, 28759 Bremen, Germany
    J Biol Chem 280:13341-8. 2005
    ..We show here that Dnmt3L stimulates the catalytic activity of the Dnmt3A and Dnmt3B enzymes by directly binding to their respective catalytic domains via its own C-terminal domain...
  23. ncbi De novo DNA methyltransferases Dnmt3a and Dnmt3b primarily mediate the cytotoxic effect of 5-aza-2'-deoxycytidine
    Masahiro Oka
    Department of Pathology, University of Florida College of Medicine, PO Box 100275, 1600 SW Archer Rd, Gainesville, FL 32610, USA
    Oncogene 24:3091-9. 2005
    ..Of interest, Dnmt3a-Dnmt3b double null ES cells were highly resistant to 5-aza-dC when compared to wild type, Dnmt3a null, Dnmt3b null, or ..
  24. ncbi DNA methyltransferase expression in the mouse germ line during periods of de novo methylation
    Diane J Lees-Murdock
    Cancer and Ageing Research Group, School of Biomedical Sciences, University of Ulster, Coleraine, United Kingdom
    Dev Dyn 232:992-1002. 2005
    DNA methyltransferase (DNMT) 3A and DNMT3B are both active de novo DNA methyltransferases required for development, whereas DNMT3L, which has no demonstrable methyltransferase activity, is required for methylation of imprinted genes in ..
  25. ncbi Inactivation of Dnmt3b in mouse embryonic fibroblasts results in DNA hypomethylation, chromosomal instability, and spontaneous immortalization
    Jonathan E Dodge
    Cardiovascular Research Center and Cancer Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Biol Chem 280:17986-91. 2005
    ..In this study, we have investigated how targeted disruption of the DNA methyltransferases Dnmt3a and Dnmt3b affects the growth of mouse embryonic fibroblasts (MEFs). Our studies led to the following observations...
  26. pmc Lsh is involved in de novo methylation of DNA
    Heming Zhu
    Laboratory of Cancer Prevention, SAIC FCRDC, Basic Research Program, National Cancer Institute, Frederick, MD 21701 1201, USA
    EMBO J 25:335-45. 2006
    ..Dnmt1 occurring at the replication fork, and de novo methylation established by the methyltransferases Dnmt3a and Dnmt3b. Using an episomal vector in Lsh-/- embryonic fibroblasts, we demonstrate that the acquisition of DNA methylation ..
  27. ncbi CpG sites preferentially methylated by Dnmt3a in vivo
    Masahiro Oka
    Department of Pathology, Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610, USA
    J Biol Chem 281:9901-8. 2006
    Dnmt3a and Dnmt3b are two major de novo DNA methyltransferases essential for embryonic development in mammals...
  28. ncbi Roles for Dnmt3b in mammalian development: a mouse model for the ICF syndrome
    Yoshihide Ueda
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Development 133:1183-92. 2006
    ..anomalies) syndrome is a rare autosomal recessive disease caused by mutations in the DNA methyltransferase gene DNMT3B. To investigate the function of Dnmt3b in mouse development and to create animal models for ICF syndrome, we have ..
  29. ncbi Mutations in DNA methyltransferase DNMT3B in ICF syndrome affect its regulation by DNMT3L
    Zheng Hua Xie
    The State Key Laboratory of Molecular Biology, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China
    Hum Mol Genet 15:1375-85. 2006
    Deficiency in DNA methyltransferase DNMT3B causes a recessive human disorder characterized by immunodeficiency, centromeric instability and facial anomalies (ICF) in association with defects in genomic methylation...
  30. ncbi DNA methyltransferases control telomere length and telomere recombination in mammalian cells
    Susana Gonzalo
    Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre CNIO, Madrid E 28029, Spain
    Nat Cell Biol 8:416-24. 2006
    ..Mouse embryonic stem (ES) cells genetically deficient for DNMT1, or both DNMT3a and DNMT3b have dramatically elongated telomeres compared with wild-type controls...
  31. ncbi Dynamic expression of DNMT3a and DNMT3b isoforms during male germ cell development in the mouse
    Sophie La Salle
    Department of Pharmacology and Therapeutics, and Montreal Children s Hospital Research Institute, McGill University, Montreal, QC, Canada H3H 1P3
    Dev Biol 296:71-82. 2006
    ..We compared the temporal expression patterns of the postulated de novo DNA methyltransferases DNMT3a and DNMT3b in murine male germ cells...
  32. ncbi Maintenance of self-renewal ability of mouse embryonic stem cells in the absence of DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b
    Akiko Tsumura
    Laboratory for Mammalian Epigenetic Studies, Center for Developmental Biology, RIKEN, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe 650 0047, Japan
    Genes Cells 11:805-14. 2006
    DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b cooperatively regulate cytosine methylation in CpG dinucleotides in mammalian genomes, providing an epigenetic basis for gene silencing and maintenance of genome integrity...
  33. pmc Coordinate regulation of DNA methyltransferase expression during oogenesis
    Diana Lucifero
    Montreal Children s Hospital Research Institute and Department of Pediatrics, McGill University, Montreal, Quebec, Canada
    BMC Dev Biol 7:36. 2007
    ..Here we report the expression dynamics of Dnmt3a and Dnmt3b, as well as a regulator of DNA methylation, Dnmt3L, in isolated female germ cells.
  34. ncbi Role of the Dnmt3 family in de novo methylation of imprinted and repetitive sequences during male germ cell development in the mouse
    Yuzuru Kato
    Department of Integrated Genetics, National Institute of Genetics, Mishima, Shizuoka, Japan
    Hum Mol Genet 16:2272-80. 2007
    ..Furthermore, we have examined the roles of the de novo methyltransferases (Dnmt3a and Dnmt3b) and related protein (Dnmt3L) in this process...
  35. pmc Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog
    Jing Yu Li
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, People s Republic of China
    Mol Cell Biol 27:8748-59. 2007
    DNA methylation plays an important role in gene silencing in mammals. Two de novo methyltransferases, Dnmt3a and Dnmt3b, are required for the establishment of genomic methylation patterns in development...
  36. ncbi The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA
    Jafar Sharif
    Tohoku University Biomedical Engineering Research Organization TUBERO, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Nature 450:908-12. 2007
    ..The link between hemi-methylated DNA, Np95 and Dnmt1 thus establishes key steps of the mechanism for epigenetic inheritance of DNA methylation...
  37. pmc Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing
    Heinz G Linhart
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Genes Dev 21:3110-22. 2007
    ....
  38. pmc Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development
    Ryutaro Hirasawa
    Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Research Organization of Information and Systems, Mishima 411 8540, Japan
    Genes Dev 22:1607-16. 2008
    ..Here we demonstrate, by using conditional knockout mice, that the other known DNA methyltransferases Dnmt3a and Dnmt3b are dispensable for the maintenance of the methylation marks at most imprinted loci...
  39. doi Dynamic transition of Dnmt3b expression in mouse pre- and early post-implantation embryos
    Ryutaro Hirasawa
    Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Research Organization of Information and Systems, Mishima 411 8540, Japan
    Gene Expr Patterns 9:27-30. 2009
    The de novo DNA methyltransferases, Dnmt3a and Dnmt3b, are responsible for the creation of DNA methylation patterns in mouse development...
  40. pmc De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes
    Silvina Epsztejn-Litman
    Department of Experimental Medicine and Cellular Biochemistry, Hebrew University Medical School, Ein Kerem, Jerusalem 91120, Israel
    Nat Struct Mol Biol 15:1176-83. 2008
    ..G9a itself is capable of bringing about de novo methylation through its ankyrin domain, by recruiting Dnmt3a and Dnmt3b independently of its histone methyltransferase activity...
  41. pmc DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions
    Suhasni Gopalakrishnan
    Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL 32610, USA
    Hum Mol Genet 18:3178-93. 2009
    ..methylation patterns are mediated by the combined action of three DNA methyltransferases: DNMT1, DNMT3A and DNMT3B. Compelling links exist between DNMT3B and chromosome stability as emphasized by the mitotic defects that are a ..
  42. doi DNA demethylation in hormone-induced transcriptional derepression
    Mi Sun Kim
    ERATO, Japan Science and Technology Agency, 4 1 8 Honcho, Kawaguchisi, Saitama 332 0012, Japan
    Nature 461:1007-12. 2009
    ..with the nVDRE-binding protein (VDIR, also known as TCF3) identified two DNA methyltransferases, DNMT1 and DNMT3B, for methylation of CpG sites, as well as a DNA glycosylase, MBD4 (ref. 10)...
  43. pmc DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis
    Mrinal Y Shah
    Section of Hematology Oncology, Department of Medicine, The University of Chicago, Chicago, Illinois 60637 1470, USA
    Cancer Res 70:5840-50. 2010
    ..To test if a truncated DNMT3B isoform disrupts DNA methylation in vivo, we constructed two lines of transgenic mice expressing DNMT3B7, a ..
  44. doi Targets and dynamics of promoter DNA methylation during early mouse development
    Julie Borgel
    Institute of Molecular Genetics, Centre National de la Recherche Scientifique CNRS UMR 5535, Universite Montpellier 2, Universite Montpellier 1, Montpellier, France
    Nat Genet 42:1093-100. 2010
    ..De novo methylation during early embryogenesis is catalyzed by Dnmt3b, and absence of DNA methylation leads to ectopic gene activation in the embryo...
  45. pmc DNA methylation and SETDB1/H3K9me3 regulate predominantly distinct sets of genes, retroelements, and chimeric transcripts in mESCs
    Mohammad M Karimi
    Department of Medical Genetics, Life Sciences Institute, The University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
    Cell Stem Cell 8:676-87. 2011
    ..Setdb1 are distinct from those derepressed in mESC deficient in the DNA methyltransferases Dnmt1, Dnmt3a, and Dnmt3b, with the exception of a small number of primarily germline-specific genes...
  46. pmc The PWWP domain of mammalian DNA methyltransferase Dnmt3b defines a new family of DNA-binding folds
    Chen Qiu
    Department of Biochemistry, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, USA
    Nat Struct Biol 9:217-24. 2002
    ..sequence motif found in > 60 eukaryotic proteins, including the mammalian DNA methyltransferases Dnmt3a and Dnmt3b. These proteins often contain other chromatin-association domains...
  47. doi Distinct nuclear localization patterns of DNA methyltransferases in developing and mature mammalian retina
    Igor O Nasonkin
    Neurobiology Neurodegeneration and Repair Laboratory N NRL, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Comp Neurol 519:1914-30. 2011
    DNA methyltransferases--DNMT1, DNMT3a, and DNMT3b--produce methylation patterns that dynamically regulate chromatin remodeling and gene expression...
  48. pmc Genes methylated by DNA methyltransferase 3b are similar in mouse intestine and human colon cancer
    Eveline J Steine
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology MIT, Cambridge, Massachusetts, USA
    J Clin Invest 121:1748-52. 2011
    ..we have addressed some of these issues by demonstrating that transgenic expression of DNA methyltransferase 3b (Dnmt3b) in the mouse colon initiates de novo DNA methylation of genes that are similar to genes that become methylated in ..
  49. pmc De novo DNA methylation by Dnmt3a and Dnmt3b is dispensable for nuclear reprogramming of somatic cells to a pluripotent state
    Mathias Pawlak
    The Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Genes Dev 25:1035-40. 2011
    ..studies, we generated iPSCs from fibroblasts that were deficient in de novo DNA methylation mediated by Dnmt3a and Dnmt3b. These iPSCs reactivated pluripotency genes, underwent self-renewal, and showed restricted developmental potential ..
  50. pmc DNA methyltransferase 3a limits the expression of interleukin-13 in T helper 2 cells and allergic airway inflammation
    Qing Yu
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Proc Natl Acad Sci U S A 109:541-6. 2012
    ..However, the specific functions of the de novo methyltransferases Dnmt3a and Dnmt3b in cytokine gene regulation have not been defined...
  51. pmc The mammalian de novo DNA methyltransferases DNMT3A and DNMT3B are also DNA 5-hydroxymethylcytosine dehydroxymethylases
    Chun Chang Chen
    Institute of Molecular Biology, Academia Sinica, Nankang, Taipei 115, Taiwan
    J Biol Chem 287:33116-21. 2012
    ..We present in vitro evidence that the mammalian de novo DNA methyltransferases DNMT3A and DNMT3B, but not the maintenance enzyme DNMT1, are also redox-dependent DNA dehydroxymethylases...
  52. doi Plasticity in Dnmt3L-dependent and -independent modes of de novo methylation in the developing mouse embryo
    Mounia Guenatri
    Inserm U934 UMR3215, Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Development 140:562-72. 2013
    ..This study proves that the postimplantation embryo is more plastic than the germline in terms of DNA methylation mechanistic choices and, importantly, that de novo methylation can be achieved in vivo without Dnmt3L...
  53. doi Dnmt3L antagonizes DNA methylation at bivalent promoters and favors DNA methylation at gene bodies in ESCs
    Francesco Neri
    Human Genetics Foundation HuGeF, Via Nizza 52, 10126 Torino, Italy
    Cell 155:121-34. 2013
    ..3-like (Dnmt3L) is a catalytically inactive DNA methyltransferase that cooperates with Dnmt3a and Dnmt3b to methylate DNA...
  54. doi Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation
    Shay Geula
    The Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Science 347:1002-6. 2015
    ..This study highlights a critical role for an mRNA epigenetic modification in vivo and identifies regulatory modules that functionally influence naïve and primed pluripotency in an opposing manner. ..
  55. doi Regulation of retinoid X receptor gamma expression by fed state in mouse liver
    Sangkyu Park
    Department of Biochemistry, College of Medicine, Catholic Kwandong University, Gangneung 210 701, Republic of Korea Electronic address
    Biochem Biophys Res Commun 458:134-9. 2015
    ..These results suggest that RXRγ may play an important role in tight control of glucose metabolism in the fasting-feeding cycle. ..
  56. pmc Δ9-Tetrahydrocannabinol-mediated epigenetic modifications elicit myeloid-derived suppressor cell activation via STAT3/S100A8
    Jessica Margaret Sido
    Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, USA and WJB Dorn Veterans Affairs Medical Center, Columbia, South Carolina, USA
    J Leukoc Biol 97:677-88. 2015
    ..Administration of THC into WT mice caused increased methylation at the promoter region of DNMT3a and DNMT3b in THC-induced MDSCs, which correlated with reduced expression of DNMT3a and DNMT3b...
  57. pmc Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells
    Jing Liao
    1 Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA 2 Harvard Stem Cell Institute, Cambridge, Massachusetts, USA 3 Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA
    Nat Genet 47:469-78. 2015
    ..Disruption of DNMT3A or DNMT3B individually as well as of both enzymes in tandem results in viable, pluripotent cell lines with distinct effects ..
  58. pmc Effect of 50 Hz Extremely Low-Frequency Electromagnetic Fields on the DNA Methylation and DNA Methyltransferases in Mouse Spermatocyte-Derived Cell Line GC-2
    Yong Liu
    College of Bioengineering, Chongqing University, Chongqing 400044, China Institute of Toxicology, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China
    Biomed Res Int 2015:237183. 2015
    ..The expression of DNMT1 and DNMT3b was decreased at 1 mT, and 50 Hz ELF-EMF can increase the expression of DNMT1 and DNMT3b of GC-2 cells at 3 mT...
  59. doi De novo DNA methylation through the 5'-segment of the H19 ICR maintains its imprint during early embryogenesis
    Hitomi Matsuzaki
    Faculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8577, Japan Life Science Center of Tsukuba Advanced Research Alliance TARA, University of Tsukuba, Tsukuba, Ibaraki 305 8577, Japan
    Development 142:3833-44. 2015
    ....
  60. pmc A comprehensive analysis of radiosensitization targets; functional inhibition of DNA methyltransferase 3B radiosensitizes by disrupting DNA damage regulation
    Hiroaki Fujimori
    Division of Genome Stability Research, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Sci Rep 5:18231. 2015
    ..of radiosensitization targets in HeLa cells was performed using a shRNA-library/functional cluster analysis and DNMT3B was identified as a candidate target...
  61. pmc Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis
    Ryan A Hlady
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 5950, USA
    J Clin Invest 122:163-77. 2012
    DNA methyltransferase 3B (Dnmt3b) belongs to a family of enzymes responsible for methylation of cytosine residues in mammals...
  62. pmc RYBP represses endogenous retroviruses and preimplantation- and germ line-specific genes in mouse embryonic stem cells
    Kaori Hisada
    Immunoepigenetics, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
    Mol Cell Biol 32:1139-49. 2012
    ..Also, they suggest a role for RYBP in epigenetic resetting during preimplantation development through repression of germ line genes and PcG targets before formation of pluripotent epiblast cells...
  63. doi Roles of Mis18α in epigenetic regulation of centromeric chromatin and CENP-A loading
    Ik Soo Kim
    Department of Biological Sciences, Creative Research Initiative Center for Chromatin Dynamics, Seoul National University, Seoul, South Korea
    Mol Cell 46:260-73. 2012
    ..Together, our findings uncover the functional mechanism of Mis18α and its pivotal role in mammalian cell cycle...
  64. pmc H1 linker histone promotes epigenetic silencing by regulating both DNA methylation and histone H3 methylation
    Seung Min Yang
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 110:1708-13. 2013
    ..Some, but not all, murine H1 subtypes interact with DNA methyltransferases DNMT1 and DNMT3B. The interactions are direct and require a portion of the H1 C-terminal domain...
  65. pmc The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome
    R S Hansen
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 96:14412-7. 1999
    ..methyltransferases, we identified a genomic sequence in the ICF region that contains the homologue of the mouse Dnmt3b methyltransferase gene...
  66. ncbi DNA methyltransferase 3b contributes to oncogenic transformation induced by SV40T antigen and activated Ras
    Kenzo Soejima
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Oncogene 22:4723-33. 2003
    ..Here we show that a de novo DNA methyltransferase, DNMT3b, substantially contributes to the oncogenic phenotype in a lung cancer model...
  67. ncbi Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns
    Jeffrey M Craig
    Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Victoria, Australia
    Hum Mol Genet 12:3109-21. 2003
    ..regions; and (b) heterochromatin-associated proteins (MeCP2, MBD1, MBD2, ATRX, HP1alpha, HDAC1, HDAC2, DNMT1 and DNMT3b), which colocalize with centromeric/pericentric heterochromatin and all other major heterochromatic sites...
  68. ncbi Chromatin targeting of de novo DNA methyltransferases by the PWWP domain
    Ying Zi Ge
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China
    J Biol Chem 279:25447-54. 2004
    ..Two de novo DNA methyltransferases, Dnmt3a and Dnmt3b, are responsible for the process...
  69. pmc Preference of DNA methyltransferases for CpG islands in mouse embryonic stem cells
    Naka Hattori
    Laboratory of Cellular Biochemistry, Animal Resource Sciences Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    Genome Res 14:1733-40. 2004
    ..components, we investigated the genome-wide DNA methylation pattern of the T-DMRs with Dnmt1-, Dnmt3a-, and/or Dnmt3b-deficient ES cells by restriction landmark genomic scanning (RLGS)...
  70. ncbi Sex- and tissue-specific expression of maintenance and de novo DNA methyltransferases upon low dose X-irradiation in mice
    Joe Raiche
    Department of Biological Sciences, University of Lethbridge, 4401 University Drive, Lethbridge, Alta, Canada T1K 3M4
    Biochem Biophys Res Commun 325:39-47. 2004
    ..the radiation-induced changes in expression of maintenance DNMT1, and de novo methyltransferases DNMT3a and DNMT3b in spleen and liver of irradiated animals...
  71. pmc DNA methyltransferase 3b regulates nerve growth factor-induced differentiation of PC12 cells by recruiting histone deacetylase 2
    Shoumei Bai
    Department of Molecular and Cellular Biochemistry, College of Medicine, The Ohio State University, Columbus, OH 43210, USA
    Mol Cell Biol 25:751-66. 2005
    ..The mRNA and protein levels of de novo methyltransferase Dnmt3b increased, whereas those of Dnmt3a and Dnmt1 decreased, during NGF-induced neurite outgrowth...
  72. ncbi Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system
    Jian Feng
    Department of Human Genetics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    J Neurosci Res 79:734-46. 2005
    ..of DNA methylation in the brain, we examined the expression pattern of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the mouse central nervous system (CNS)...
  73. ncbi Transcriptome analysis in blastocyst hatching by cDNA microarray
    Huei Wen Chen
    Institute and Department of Pharmacology, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Hum Reprod 20:2492-501. 2005
    ..However, little is known about its regulatory mechanisms. By integrating the technologies of RNA amplification and cDNA microarrays, it has become possible to study the gene expression profile at this critical stage...
  74. ncbi Expression and functional analysis of genes deregulated in mouse placental overgrowth models: Car2 and Ncam1
    Umashankar Singh
    Department of Development and Genetics, Evolutionary Biology Center, Uppsala University, Sweden
    Dev Dyn 234:1034-45. 2005
    ..This strongly suggested that altered expression of Car2 and Ncam1 is a downstream event in placental hyperplasia...
  75. pmc Suppression of intestinal neoplasia by deletion of Dnmt3b
    Haijiang Lin
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02141, USA
    Mol Cell Biol 26:2976-83. 2006
    ..Using conditional inactivation of de novo methyltransferase Dnmt3b in Apc(Min/+) mice, we demonstrate that the loss of Dnmt3b has no impact on microadenoma formation, which is ..
  76. ncbi Selection of neural differentiation-specific genes by comparing profiles of random differentiation
    Min Su Lee
    Department of Computer Science and Engineering, Ewha Womans University, Seoul, Korea
    Stem Cells 24:1946-55. 2006
    ....
  77. pmc Role of DNA methyltransferases in regulation of human ribosomal RNA gene transcription
    Sarmila Majumder
    Department of Molecular and Cellular Biochemistry, College of Medicine, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 281:22062-72. 2006
    ..Immunofluorescence analysis and biochemical fractionation showed that all three DNMTs (DNMT1, DNMT3A, and DNMT3B) are associated with the inactive rDNA in the nucleolus...
  78. pmc Lsh controls Hox gene silencing during development
    Sichuan Xi
    Laboratory of Cancer Prevention, SAIC Frederick, National Cancer Institute, Frederick, MD 21702 1201, USA
    Proc Natl Acad Sci U S A 104:14366-71. 2007
    ..We demonstrate that Lsh, a SNF2 homolog, can associate with some Hox genes and regulates Dnmt3b binding, DNA methylation, and silencing of Hox genes during development...
  79. ncbi Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II
    Stefan Schoeftner
    Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre CNIO, 28029 Madrid, Spain
    Nat Cell Biol 10:228-36. 2008
    ..Our results indicate that TelRNAs are novel components of mammalian telomeres, which are anticipated to be fundamental for understanding telomere biology and telomere-related diseases, such as cancer and ageing...
  80. pmc Characterization of Dnmt3b:thymine-DNA glycosylase interaction and stimulation of thymine glycosylase-mediated repair by DNA methyltransferase(s) and RNA
    Michael J Boland
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Mol Biol 379:492-504. 2008
    ..patterns are established and maintained at CpG dinucleotides by DNA methyltransferases (Dnmt1, Dnmt3a, and Dnmt3b). In mammals and many other eukaryotes, the CpG dinucleotide is underrepresented in the genome...
  81. doi Regulation of DNA methylation activity through Dnmt3L promoter methylation by Dnmt3 enzymes in embryonic development
    Ye Guang Hu
    The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, People s Republic of China
    Hum Mol Genet 17:2654-64. 2008
    The genomic DNA is methylated by de novo methyltransferases Dnmt3a and Dnmt3b during early embryonic development. The establishment of appropriate methylation patterns depends on a fine regulation of the methyltransferase activity...
  82. doi DNA methyltransferase 3B acts as a co-repressor of the human polycomb protein hPc2 to repress fibroblast growth factor receptor 3 transcription
    Sung Hak Kim
    National Research Laboratory for Cancer Epigenetics, Cancer Research Institute, Republic of Korea
    Int J Biochem Cell Biol 40:2462-71. 2008
    ..Taken together, these results suggest that DNA methyltransferase 3B functions as a co-repressor of polycomb protein in inducing transcriptional repression independent of DNA methylation...
  83. doi Multiplex rt-PCR expression analysis of developmentally important genes in individual mouse preimplantation embryos and blastomeres
    Andreas May
    Institute for Human Genetics, Johannes Gutenberg University Mainz, 55101 Mainz, Germany
    Biol Reprod 80:194-202. 2009
    ..Immunolocalization of DNMT3A, MBD3, APEX1, and LIG3 in most or all nuclei of 40-60-cell embryos is a good indicator of functional activity of genes that are activated by the 16-cell stage...
  84. doi De novo DNA methylation independent establishment of maternal imprint on X chromosome in mouse oocytes
    Hatsune Chiba
    Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Research Organization of Information and Systems, 1111 Yata, Mishima, Japan
    Genesis 46:768-74. 2008
    ..This underscores the difference between imprinted XCI and autosomal imprinting...
  85. doi Abnormal DNA methyltransferase expression in mouse germline stem cells results in spermatogenic defects
    Seiji Takashima
    Department of Molecular Genetics, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Biol Reprod 81:155-64. 2009
    ..In contrast, GS cells proliferated normally in vitro after Dnmt3a/Dnmt3b ablation or during Dnmt3l overexpression...
  86. pmc Potential role of miR-29b in modulation of Dnmt3a and Dnmt3b expression in primordial germ cells of female mouse embryos
    Shuji Takada
    Division of Functional Genomics, Jichi Medical University, 3311 1 Yakushiji, Shimotsukeshi, Tochigi 329 0498, Japan
    RNA 15:1507-14. 2009
    ..Transcripts of the human genes for the de novo methyltransferases DNMT3A and DNMT3B have been identified as targets of miR-29b, and we found that mouse miR-29b also negatively regulates Dnmt3a and ..
  87. pmc Lsh participates in DNA methylation and silencing of stem cell genes
    Sichuan Xi
    Laboratory of Cancer Prevention, SAIC Frederick, National Cancer Institute, Frederick, MD 21701, USA
    Stem Cells 27:2691-702. 2009
    ..of DNA methylation patterns at stem cell genes during differentiation, in part by regulating access of Dnmt3b to its genomic targets...
  88. pmc Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells
    Daniela Meilinger
    Department of Biology II, Center for Integrated Protein Science Munich CIPSM, Ludwig Maximilians University Munich, Grosshaderner Street 2, 82152 Planegg Martinsried, Germany
    EMBO Rep 10:1259-64. 2009
    ..we show that Np95 interacts more strongly with regulatory domains of the de novo methyltransferases Dnmt3a and Dnmt3b. To investigate possible functions, we developed an epigenetic silencing assay using fluorescent reporters in ..
  89. pmc Targeting of 5-aza-2'-deoxycytidine residues by chromatin-associated DNMT1 induces proteasomal degradation of the free enzyme
    Katan Patel
    Breakthrough Research Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK
    Nucleic Acids Res 38:4313-24. 2010
    ..The proteasome inhibitor MG132 prevents DNMT1 degradation and reduces hypomethylation induced by 5-aza-dC...
  90. pmc Dnmt3b recruitment through E2F6 transcriptional repressor mediates germ-line gene silencing in murine somatic tissues
    Guillaume Velasco
    Centre National de la Recherche Scientifique, University Paris Diderot, 75013 Paris, France
    Proc Natl Acad Sci U S A 107:9281-6. 2010
    ..Here, we focused on the functions of DNA methyltransferase-3b (Dnmt3b), of which deregulated activity is linked to several human pathologies...
  91. pmc Epigenetic regulation of myofibroblast differentiation by DNA methylation
    Biao Hu
    Department of Pathology, University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109 2200, USA
    Am J Pathol 177:21-8. 2010
    ..These findings suggest that DNA methylation mediated by DNA methyltransferase is an important mechanism regulating the alpha-SMA gene expression during myofibroblast differentiation...
  92. pmc A single amino acid substitution confers enhanced methylation activity of mammalian Dnmt3b on chromatin DNA
    Li Shen
    Laboratory of Molecular Cell Biology and Center of Cell Signaling, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, PR China
    Nucleic Acids Res 38:6054-64. 2010
    Dnmt3a and Dnmt3b are paralogous enzymes responsible for de novo DNA methylation but with distinguished biological functions...
  93. doi DNA methylase and demethylase activities are modulated by one-carbon metabolism in Alzheimer's disease models
    Andrea Fuso
    Department of Surgery P Valdoni, Sapienza University of Rome, P le Aldo Moro, 5 00185, Rome, Italy
    J Nutr Biochem 22:242-51. 2011
    ..We found that DNA methylases (DNMT1, 3a and 3b) and a putative demethylase (MBD2) were differently modulated, in line with the previously observed changes of PSEN1 methylation pattern in the same experimental conditions...
  94. ncbi Stage-by-stage change in DNA methylation status of Dnmt1 locus during mouse early development
    Yeoung Gyu Ko
    Laboratory of Cellular Biochemistry, Department of Animal Resource Sciences Veterinary Medical Sciences, The University of Tokyo, Tokyo, Japan 113 8657
    J Biol Chem 280:9627-34. 2005
    ..Analysis using Dnmt-deficient embryonic stem cell lines revealed that Dnmt1, Dnmt3a, and Dnmt3b are each partially responsible for maintenance of methylation of Dnmt1o T-DMR...
  95. ncbi Transition of mouse de novo methyltransferases expression from Dnmt3b to Dnmt3a during neural progenitor cell development
    D Watanabe
    Laboratory of Molecular Embryology, Department of Bioscience, Kitasato University School of Science, 1 15 1, Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    Neuroscience 142:727-37. 2006
    Dnmt3a and Dnmt3b, which are known as functional de novo methyltransferases, are responsible for creating genomic methylation patterns during mammalian development...
  96. pmc DNA methylation affects nuclear organization, histone modifications, and linker histone binding but not chromatin compaction
    Nick Gilbert
    Medical Research Council Human Genetics Unit, Edinburgh, Scotland, UK
    J Cell Biol 177:401-11. 2007
    ....
  97. ncbi Deoxyribonucleic acid methyl transferases 3a and 3b associate with the nuclear orphan receptor COUP-TFI during gene activation
    Rozenn Gallais
    Unité Mixte de Recherche 6026, Centre National de la Recherche Scientifique, Universite Rennes I, Institut Fédératif de Recherche 140 Génomique Fonctionnelle Agronomie Santé, Equipe Information et Programmation Cellulaire, France
    Mol Endocrinol 21:2085-98. 2007
    ..These results suggest that Dnmt3a/b could cooperate with the orphan receptor COUP-TFI to regulate transcription of the vitronectin gene...
  98. ncbi Telomere lengthening early in development
    Lin Liu
    Laboratory for Reproductive Medicine, Department of Obstetrics and Gynecology, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    Nat Cell Biol 9:1436-41. 2007
    ....
  99. doi The effects of trichostatin A on mRNA expression of chromatin structure-, DNA methylation-, and development-related genes in cloned mouse blastocysts
    Xiangping Li
    Laboratory of Animal Reproduction, College of Agriculture, Kinki University, Nara, Japan
    Cloning Stem Cells 10:133-42. 2008
    ..developed from TSA-treated SCNT oocytes exhibited similar expression patterns for Hdac1, 2, and 3, CBP, PCAF, and Dnmt3b genes compared with in vitro-developed blastocysts and blastocysts developed from SCNT oocytes without TSA ..
  100. ncbi [Biochemistry of DNA methyltransferases]
    Isao Suetake
    Tanpakushitsu Kakusan Koso 53:823-9. 2008
  101. pmc Centromere mitotic recombination in mammalian cells
    Isabel Jaco
    Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre, 28029 Madrid, Spain
    J Cell Biol 181:885-92. 2008
    ..Furthermore, we show that centromere mitotic recombination is increased in cells lacking the Dnmt3a and Dnmt3b DNA methyltransferases, suggesting that the epigenetic state of centromeric heterochromatin controls recombination ..

Research Grants3

  1. REGULATION OF INDUCIBLE NITRIC OXIDE SYNTHASE IN KIDNEY
    BRUCE KONE; Fiscal Year: 2002
    ....
  2. Postdoctoral Training in Renal Diseases and Hypertension
    BRUCE KONE; Fiscal Year: 2006
    ..It is the goal of the Program that its graduates will contribute to a new generation of academic nephrologists and renal investigators equipped to address the challenging problems in renal diseases and hypertension ..
  3. Regulation of H/K-ATPase in Kidney and Colon
    BRUCE KONE; Fiscal Year: 2009
    ..abstract_text> ..