Egr2

Summary

Gene Symbol: Egr2
Description: early growth response 2
Alias: Egr-2, Krox-20, Krox20, NGF1-B, Zfp-25, Zfp-6, E3 SUMO-protein ligase EGR2, early growth response protein 2, zinc finger protein Krox-20
Species: mouse

Top Publications

  1. pmc A recurrent network involving the transcription factors PU.1 and Gfi1 orchestrates innate and adaptive immune cell fates
    Chauncey J Spooner
    Howard Hughes Medical Institute, The University of Chicago, GCIS W522, Chicago, IL 60637, USA
    Immunity 31:576-86. 2009
  2. ncbi Severe neuropathies in mice with targeted mutations in the ErbB3 receptor
    D Riethmacher
    Department of Medical Genetics, Max Delbrueck Center for Molecular Medicine, Berlin, Germany
    Nature 389:725-30. 1997
  3. pmc Mice lacking ZFHX1B, the gene that codes for Smad-interacting protein-1, reveal a role for multiple neural crest cell defects in the etiology of Hirschsprung disease-mental retardation syndrome
    Tom Van de Putte
    Department of Developmental Biology, Flanders Interuniversity Institute for Biotechnology, and Laboratory of Molecular Biology Celgen, University of Leuven, Leuven, Belgium
    Am J Hum Genet 72:465-70. 2003
  4. pmc Atoh1-lineal neurons are required for hearing and for the survival of neurons in the spiral ganglion and brainstem accessory auditory nuclei
    Stephen M Maricich
    Department of Pediatrics and Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Neurosci 29:11123-33. 2009
  5. pmc Npn-1 contributes to axon-axon interactions that differentially control sensory and motor innervation of the limb
    Rosa Eva Huettl
    Institute of Developmental Genetics, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    PLoS Biol 9:e1001020. 2011
  6. pmc The Ras/MAPK pathway is required for generation of iNKT cells
    Taishan Hu
    Immunobiology and Cancer Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America
    PLoS ONE 6:e19890. 2011
  7. ncbi Krox-20 controls myelination in the peripheral nervous system
    P Topilko
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, Paris, France
    Nature 371:796-9. 1994
  8. ncbi Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins
    T Herdegen
    Institute of Pharmacology, University of Kiel, Hospitalstrasse 4, 24105, Kiel
    Brain Res Brain Res Rev 28:370-490. 1998
  9. ncbi Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation
    D Acampora
    International Institute of Genetics and Biophysics CNR, Naples, Italy
    Development 121:3279-90. 1995
  10. ncbi Glucocorticoids inhibit osteocalcin transcription in osteoblasts by suppressing Egr2/Krox20-binding enhancer
    Nathalie Leclerc
    University of Southern California Keck School of Medicine, Los Angeles 90033, USA
    Arthritis Rheum 52:929-39. 2005

Research Grants

Scientific Experts

Detail Information

Publications157 found, 100 shown here

  1. pmc A recurrent network involving the transcription factors PU.1 and Gfi1 orchestrates innate and adaptive immune cell fates
    Chauncey J Spooner
    Howard Hughes Medical Institute, The University of Chicago, GCIS W522, Chicago, IL 60637, USA
    Immunity 31:576-86. 2009
    ..These findings have important implications for the evolution of the adaptive immune system...
  2. ncbi Severe neuropathies in mice with targeted mutations in the ErbB3 receptor
    D Riethmacher
    Department of Medical Genetics, Max Delbrueck Center for Molecular Medicine, Berlin, Germany
    Nature 389:725-30. 1997
    ..Our results indicate that sensory and motor neurons require factors for their survival that are provided by developing Schwann cells...
  3. pmc Mice lacking ZFHX1B, the gene that codes for Smad-interacting protein-1, reveal a role for multiple neural crest cell defects in the etiology of Hirschsprung disease-mental retardation syndrome
    Tom Van de Putte
    Department of Developmental Biology, Flanders Interuniversity Institute for Biotechnology, and Laboratory of Molecular Biology Celgen, University of Leuven, Leuven, Belgium
    Am J Hum Genet 72:465-70. 2003
    ..Furthermore, we show that Sip1 is involved in the specification of neuroepithelium...
  4. pmc Atoh1-lineal neurons are required for hearing and for the survival of neurons in the spiral ganglion and brainstem accessory auditory nuclei
    Stephen M Maricich
    Department of Pediatrics and Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Neurosci 29:11123-33. 2009
    ..We used the Cre-loxP system and two Cre-driver lines (Egr2(Cre) and Hoxb1(Cre)) to delete Atoh1 from different regions of the cochlear nucleus (CN) and accessory auditory ..
  5. pmc Npn-1 contributes to axon-axon interactions that differentially control sensory and motor innervation of the limb
    Rosa Eva Huettl
    Institute of Developmental Genetics, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    PLoS Biol 9:e1001020. 2011
    ..Thus, motor and sensory axons are mutually dependent on each other for the generation of their trajectories and interact in part through Npn-1-mediated fasciculation before and within the plexus region of the limbs...
  6. pmc The Ras/MAPK pathway is required for generation of iNKT cells
    Taishan Hu
    Immunobiology and Cancer Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America
    PLoS ONE 6:e19890. 2011
    ..Interestingly our results also show that there are differences in the contributions of several of these molecules to the development of iNKT and conventional αβ T cells...
  7. ncbi Krox-20 controls myelination in the peripheral nervous system
    P Topilko
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, Paris, France
    Nature 371:796-9. 1994
    ..Therefore Krox-20 is likely to control a set of genes required for completion of myelination in the peripheral nervous system...
  8. ncbi Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins
    T Herdegen
    Institute of Pharmacology, University of Kiel, Hospitalstrasse 4, 24105, Kiel
    Brain Res Brain Res Rev 28:370-490. 1998
    ..We also describe their expression and possible roles in glial cells. Finally, we discuss the relevance of their expression for nervous system functioning under normal and patho-physiological conditions...
  9. ncbi Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation
    D Acampora
    International Institute of Genetics and Biophysics CNR, Naples, Italy
    Development 121:3279-90. 1995
    ....
  10. ncbi Glucocorticoids inhibit osteocalcin transcription in osteoblasts by suppressing Egr2/Krox20-binding enhancer
    Nathalie Leclerc
    University of Southern California Keck School of Medicine, Los Angeles 90033, USA
    Arthritis Rheum 52:929-39. 2005
    ..Using this gene as a model, the goal of this study was to discover glucocorticoid-sensitive transcriptional mechanisms in osteoblasts...
  11. pmc The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T cells
    Vanja Lazarevic
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nat Immunol 10:306-13. 2009
    ..In this report, we demonstrate that the transcription factor early growth response 2 (Egr2), a target gene of NFAT, was specifically required for the ontogeny of NKT cells but not that of conventional CD4(+)..
  12. ncbi Expression of Kv1.1, a Shaker-like potassium channel, is temporally regulated in embryonic neurons and glia
    J L Hallows
    The Virginia Merrill Bloedel Hearing Research Center and the Departments of Pharmacology and Otolaryngology Head and Neck Surgery, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Neurosci 18:5682-91. 1998
    ..1 in development are not understood, the cell-specific localization and timing of expression suggest this channel may play a role in several developmental processes, including proliferation, migration, or cell-cell adhesion...
  13. pmc HCF-1 functions as a coactivator for the zinc finger protein Krox20
    Randy L Luciano
    Department of Microbiology and New York University Cancer Institute, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 278:51116-24. 2003
    ..Three well characterized examples were further analyzed for their ability to use HCF-1 as a coactivator. Krox20, a zinc finger transcription factor required for Schwann cell differentiation, and E2F4, a cell cycle regulator, ..
  14. pmc EGR-2 is not required for in vivo CD4 T cell mediated immune responses
    Hilda E Ramon
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 5:e12904. 2010
    ..EGR-2 deficient mice have increased levels of CD44(high) T cells in peripheral lymphoid organs, and with age, develop autoimmune-like features...
  15. ncbi Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain
    S Schneider-Maunoury
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Biologie Moléculaire du Développement, Ecole Normale Superieure, Paris, France
    Cell 75:1199-214. 1993
    ..We conclude that Krox-20, although not required for the initial delimitation of r3 and r5, plays an important role in the process of segmentation governing hindbrain development...
  16. ncbi Expression of the mouse labial-like homeobox-containing genes, Hox 2.9 and Hox 1.6, during segmentation of the hindbrain
    P Murphy
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK
    Development 111:61-74. 1991
    ..we have investigated the expression patterns of these two genes and an additional rhombomere-specific gene, Krox 20, on consecutive embryonic sections at closely staged intervals...
  17. pmc A gene encoding a protein with zinc fingers is activated during G0/G1 transition in cultured cells
    P Chavrier
    Differentiation Programme, European Molecular Biology Laboratory, Heidelberg, FRG
    EMBO J 7:29-35. 1988
    ..In the mouse, Krox-20 is expressed at low levels in tissues which contain rapidly dividing cells. These properties suggest that Krox-20 encodes a transcription control factor, possibly involved in the modulation of cell proliferation...
  18. pmc Molecular cloning, sequencing, and mapping of EGR2, a human early growth response gene encoding a protein with "zinc-binding finger" structure
    L J Joseph
    Department of Medicine, Howard Hughes Medical Institute, Chicago, IL
    Proc Natl Acad Sci U S A 85:7164-8. 1988
    ..Using low-stringency hybridization with an Egr-1 cDNA probe, we identified a distinct human cDNA (designated EGR2 for early growth response gene-2), which is coregulated with EGR1 by fibroblast and lymphocyte mitogens; however, ..
  19. ncbi nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation
    I Varlet
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Development 124:1033-44. 1997
    ..Thus we conclude that the action of nodal, a TGFbeta-related growth factor expressed in the primitive endoderm, is critical for patterning of the anterior aspects of the A-P axis...
  20. ncbi Immediate early genes krox-24 and krox-20 are rapidly up-regulated after wounding in the embryonic and adult mouse
    Richard Grose
    Institute of Cell Biology, HPM D25, ETH Zurich, Honggerberg, Zurich, Switzerland
    Dev Dyn 223:371-8. 2002
    ..Despite the dramatic up-regulation of these genes in response to injury, our studies reveal that neither of them on their own is essential for repair...
  21. pmc Egr2 is required for Bcl-2 induction during positive selection
    Jens Peter Holst Lauritsen
    Division of Basic Sciences, Immunobiology Working Group, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Immunol 181:7778-85. 2008
    ..Accordingly, we asked whether this results from compensation by another family member, Egr2. In this manuscript, we demonstrate that deletion of Egr2 impairs positive selection of both CD4 and CD8 single-..
  22. doi Early growth response 2 regulates the survival of thymocytes during positive selection
    Victoria J Lawson
    Section of Cell and Molecular Biology, Institute of Cancer Research, London, UK
    Eur J Immunol 40:232-41. 2010
    ..We examine here the role played by Egr2 in positive selection...
  23. ncbi Segment-specific expression of a zinc-finger gene in the developing nervous system of the mouse
    D G Wilkinson
    Laboratory of Developmental Biochemistry, National Institute for Medical Research, Mill Hill, London, UK
    Nature 337:461-4. 1989
    ..The demonstration that neuromeres are domains of gene expression provides molecular evidence for the segmentation of the CNS...
  24. ncbi Loss of Hox-A1 (Hox-1.6) function results in the reorganization of the murine hindbrain
    E M Carpenter
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City 84112
    Development 118:1063-75. 1993
    ....
  25. ncbi Ectopic Hoxa-1 induces rhombomere transformation in mouse hindbrain
    M Zhang
    Department of Toxicology and Pathology, Roche Research Center, Hoffmann La Roche, Nutley, New Jersey 07110
    Development 120:2431-42. 1994
    ..Taken together, these data suggest that ectopic Hoxa-1 expression can reorganize select regions of the developing hindbrain by inducing partial transformations of several rhombomeres into a rhombomere-4-like identity...
  26. ncbi Altered rhombomere-specific gene expression and hyoid bone differentiation in the mouse segmentation mutant, kreisler (kr)
    M A Frohman
    Department of Anatomy, School of Medicine, University of California, San Francisco 94143
    Development 117:925-36. 1993
    ....
  27. ncbi Defective bone formation in Krox-20 mutant mice
    G Levi
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, Paris, France
    Development 122:113-20. 1996
    ....
  28. ncbi Segmental expression of Hoxa-2 in the hindbrain is directly regulated by Krox-20
    S Nonchev
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, London, UK
    Development 122:543-54. 1996
    ..Therefore, the segmental phenotypes in the Krox-20 mutants are likely to reflect the role of Krox-20 in directly regulating multiple Hox genes...
  29. ncbi Tissue distribution, genomic structure, and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2
    K Tsukiyama-Kohara
    Department of Biochemistry, McGill University, Montreal, Quebec, H3G 1Y6, Canada
    Genomics 38:353-63. 1996
    ..Mouse 4E-BP1 and 4E-BP2 map to chromosomes 8 (A4-B1) and 10 (B4-B5), respectively, and human 4E-BP1 and 4E-BP2 localize to chromosomes 8p12 and 10q21-q22, respectively...
  30. ncbi In vivo functional analysis of the Hoxa-1 3' retinoic acid response element (3'RARE)
    V Dupé
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, Illkirch, CU de Strasbourg, France
    Development 124:399-410. 1997
    ..Interestingly, although the RARE is not required for the spatiotemporal control of colinear expression of the Hoxa genes, it is absolutely required for correct Hoxa-2 expression in rhombomere 5...
  31. ncbi Mouse Serrate-1 (Jagged-1): expression in the developing tooth is regulated by epithelial-mesenchymal interactions and fibroblast growth factor-4
    T A Mitsiadis
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, Stockholm, Sweden
    Development 124:1473-83. 1997
    ..This indicates that, at least during tooth development, the expression patterns observed for receptors and ligands in the Notch signaling pathway are generated by different induction mechanisms...
  32. ncbi Key roles of retinoic acid receptors alpha and beta in the patterning of the caudal hindbrain, pharyngeal arches and otocyst in the mouse
    V Dupé
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, CNRS INSERM ULP College de France, B P 163, CU de Strasbourg, France
    Development 126:5051-9. 1999
    ....
  33. ncbi Expression pattern of a Krox-20/Cre knock-in allele in the developing hindbrain, bones, and peripheral nervous system
    O Voiculescu
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, Paris, France
    Genesis 26:123-6. 2000
  34. ncbi Different respiratory control systems are affected in homozygous and heterozygous kreisler mutant mice
    Fabrice Chatonnet
    Neurobiologie Genetique et Integrative, UPR2216, Centre National de la Recherche Scientifique, Institut de Neurobiologie Alfred Fessard UFR 2218, 91198 Gif sur Yvette Cedex, France
    Eur J Neurosci 15:684-92. 2002
    During embryonic development, restricted expression of the regulatory genes Krox20 and kreisler are involved in segmentation and antero-posterior patterning of the hindbrain neural tube...
  35. ncbi Neural crest boundary cap cells constitute a source of neuronal and glial cells of the PNS
    Geraldine S Maro
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, 46 rue d Ulm, 75230 Paris Cedex 05, France
    Nat Neurosci 7:930-8. 2004
    ..Using various knock-in alleles of the mouse gene Egr2 (also known as Krox20), the expression of which, in trunk regions, is initially restricted to BC cells, we were able to trace BC cell ..
  36. ncbi Direct regulation of myelin protein zero expression by the Egr2 transactivator
    Scott E Leblanc
    Molecular and Cellular Pharmacology Program, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Drive, Madison, WI 53705, USA
    J Biol Chem 281:5453-60. 2006
    ..within the first intron of the Mpz gene, which contains binding sites for the early growth response 2 (Egr2/Krox20) transcription factor, a critical regulator of peripheral nerve myelination...
  37. pmc Pulse sensitivity of the luteinizing hormone beta promoter is determined by a negative feedback loop Involving early growth response-1 and Ngfi-A binding protein 1 and 2
    Mark A Lawson
    Department of Reproductive Medicine 0674, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0674, USA
    Mol Endocrinol 21:1175-91. 2007
    ..The immediate early gene mRNAs encoding early growth response (Egr)1 and Egr2, which activate the gonadotropin LH beta-subunit gene promoter, are stably induced at high pulse frequency...
  38. pmc Active gene repression by the Egr2.NAB complex during peripheral nerve myelination
    Gennifer M Mager
    Molecular and Cellular Pharmacology Training Program, Department of Comparative Biosciences, Graduate Program in Cellular and Molecular Biology, University of Wisconsin, Madison, WI 53706, USA
    J Biol Chem 283:18187-97. 2008
    The Egr2/Krox20 transactivator is required for activation of many myelin-associated genes during peripheral nerve myelination by Schwann cells...
  39. ncbi Exogenous retinoic acid rapidly induces anterior ectopic expression of murine Hox-2 genes in vivo
    R A Conlon
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Development 116:357-68. 1992
    ....
  40. ncbi Krox-20: a candidate gene for the regulation of pattern formation in the hindbrain
    P Gilardi
    Laboratoire de Genetique Moleculaire, CNRS D 1302, Ecole Normale Superieure, Paris, France
    Biochimie 73:85-91. 1991
    ..The possible interactions between Krox-20 and homeobox containing genes as well as the search for other members of the network will be discussed...
  41. pmc The segment-specific gene Krox-20 encodes a transcription factor with binding sites in the promoter region of the Hox-1.4 gene
    P Chavrier
    European Molecular Biology Laboratory, Heidelberg, FRG
    EMBO J 9:1209-18. 1990
    ..The possible involvement of Krox-20 in the regulation of the transcription of other homeobox genes is discussed in view of their respective patterns of expression...
  42. ncbi Multiple essential functions of neuregulin in development
    D Meyer
    Nature 378:386-90. 1995
    ..All cell types affected by the mutation express either erbB3 or erbB4, indicating that either of these tyrosine kinase receptors can be a component in recognition and transmission of essential neuregulin signals...
  43. ncbi Requirement for Lim1 in head-organizer function
    W Shawlot
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Nature 374:425-30. 1995
    ..A partial secondary axis developed anteriorly in some mutant embryos. Lim1 is thus an essential regulator of the vertebrate head organizer...
  44. ncbi Anteriorization of CRABP-I expression by retinoic acid in the developing mouse central nervous system and its relationship to teratogenesis
    L Leonard
    Developmental Biology Research Centre, King s College London, United Kingdom
    Dev Biol 168:514-28. 1995
    ..The role that CRABP-I may play in normal development of the hindbrain and in teratogenesis and the similarity of these results to those obtained with various Hox genes are discussed...
  45. ncbi A homeotic transformation is generated in the rostral branchial region of the head by disruption of Hoxa-2, which acts as a selector gene
    F M Rijli
    Laboratoire de Génétique Moléculaire des Eucaryotes du Centre National de la Recherche Scientifique Unité, Institut de Chimie Biologique Faculté de Médecine
    Cell 75:1333-49. 1993
    ..The ground pattern program appears to be modified in the mouse first arch by a Hox-independent process, whereas Hoxa-2 acts as a selector gene in the second arch...
  46. ncbi The kreisler mouse: a hindbrain segmentation mutant that lacks two rhombomeres
    I J McKay
    Department of Zoology, Oxford University, UK
    Development 120:2199-211. 1994
    ..An interpretation is that the cells that would normally become specified at an early stage as r5 and r6 adopt an r4 character instead, producing an excess of r4 cells that is disposed of subsequently by cell death...
  47. ncbi Exposure to retinoic acid before or after the onset of somitogenesis reveals separate effects on rhombomeric segmentation and 3' HoxB gene expression domains
    H Wood
    Department of Human Anatomy, Oxford, UK
    Development 120:2279-85. 1994
    ....
  48. ncbi The zinc finger gene Krox20 regulates HoxB2 (Hox2.8) during hindbrain segmentation
    M H Sham
    MRC Laboratory of Eukaryotic Molecular Genetics, National Institute for Medical Research, The Ridgeway, Mill Hill, London
    Cell 72:183-96. 1993
    The zinc finger gene Krox20 and many Hox homeobox genes are expressed in segment-restricted domains in the hindbrain...
  49. ncbi Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20
    P J Swiatek
    Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110
    Genes Dev 7:2071-84. 1993
    b>Krox20 is a zinc finger gene expressed in rhombomeres 3 and 5 during hindbrain development in vertebrates...
  50. ncbi Reorganization of pontine rhythmogenic neuronal networks in Krox-20 knockout mice
    T D Jacquin
    Biologie Fonctionnelle du Neurone, Centre National de la Recherche Scientifique, Gif sur Yvette, France
    Neuron 17:747-58. 1996
    ..The newborn (PO) Krox-20-/- mice, in which apneas are ten times longer than in wild-type animals, may be a valuable model for the study of life-threatening apneas during early infancy...
  51. ncbi Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve
    J M Goddard
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah, School of Medicine, Salt Lake City 84112, USA
    Development 122:3217-28. 1996
    ..These animals should therefore provide a useful animal model for these human diseases...
  52. ncbi Altered segmental identity and abnormal migration of motor neurons in mice lacking Hoxb-1
    M Studer
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, Mill Hill, London, UK
    Nature 384:630-4. 1996
    ..These results demonstrate that, as a part of its role in maintaining rhombomere identity, Hoxb-1 is involved in controlling migratory properties of motor neurons in the hindbrain...
  53. ncbi Segmental and neuronal architecture of the hindbrain of Krox-20 mouse mutants
    S Schneider-Maunoury
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Biologie Moléculaire du Développement, Ecole Normale Superieure, Paris, France
    Development 124:1215-26. 1997
    ..This navigational error could explain the disappearance, at around 17.5 dpc, of the trigeminal motor nucleus in Krox-20(-/-) embryos by inadequate supply of essential, possibly arch-specific survival factors...
  54. ncbi Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene function
    K M Wassarman
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California, San Francisco 94143 0452, USA
    Development 124:2923-34. 1997
    ..These data provide genetic evidence for a link between patterning of the anterior hindbrain and the establishment of the mid/hindbrain organizer, and identify Gbx2 as a gene required for these processes to occur normally...
  55. pmc Null mutation of mCOUP-TFI results in defects in morphogenesis of the glossopharyngeal ganglion, axonal projection, and arborization
    Y Qiu
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Dev 11:1925-37. 1997
    ..Furthermore, mCOUP-TFI possesses vital physiological functions that are distinct from mCOUP-TFII despite of their high degree of homology and extensive overlapping expression patterns...
  56. ncbi Differential regulation of the zinc finger genes Krox-20 and Krox-24 (Egr-1) suggests antagonistic roles in Schwann cells
    P Topilko
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, Paris, France
    J Neurosci Res 50:702-12. 1997
    ..In particular, their balance of expression might participate in the choice between myelinating and nonmyelinating pathways...
  57. ncbi Segmental expression of the EphA4 (Sek-1) receptor tyrosine kinase in the hindbrain is under direct transcriptional control of Krox-20
    T Theil
    Division of Developmental Neurobiology, National Institute for Medical Research, London, UK
    Development 125:443-52. 1998
    ..Together with evidence that Krox-20 regulates Hox gene expression, our findings reveal a mechanism by which the identity and movement of cells are coupled such that sharply restricted segmental domains are generated...
  58. ncbi Genetic interactions between Hoxa1 and Hoxb1 reveal new roles in regulation of early hindbrain patterning
    M Studer
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 125:1025-36. 1998
    ..Our genetic analysis shows that individual members of the vertebrate labial-related genes have multiple roles in different steps governing segmental processes in the developing hindbrain...
  59. ncbi Hoxa1 and Krox-20 synergize to control the development of rhombomere 3
    F Helmbacher
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, 75230 Paris Cedex 05, France
    Development 125:4739-48. 1998
    ..In addition, these data suggest that the control of the development of r3 may not be autonomous but dependent on interactions with Hoxa1-expressing cells...
  60. ncbi Krox-20 controls SCIP expression, cell cycle exit and susceptibility to apoptosis in developing myelinating Schwann cells
    T S Zorick
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Development 126:1397-406. 1999
    ..These data demonstrate that the loss of Krox-20 in myelinating Schwann cells arrests differentiation at the promyelinating stage, as assessed by SCIP expression, mitotic activity and susceptibility to apoptosis...
  61. ncbi Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrain
    M Davenne
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, College de France, Strasbourg
    Neuron 22:677-91. 1999
    ....
  62. ncbi Mice mutant for both Hoxa1 and Hoxb1 show extensive remodeling of the hindbrain and defects in craniofacial development
    M Rossel
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    Development 126:5027-40. 1999
    ....
  63. ncbi Nab proteins mediate a negative feedback loop controlling Krox-20 activity in the developing hindbrain
    F Mechta-Grigoriou
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, Paris France
    Development 127:119-28. 2000
    ..Taken together, these data indicate that Krox-20 positively regulates the expression of its own antagonists and raise the possibility that this negative feedback regulatory loop may play a role in the control of hindbrain development...
  64. ncbi Roles of Hoxa1 and Hoxa2 in patterning the early hindbrain of the mouse
    J R Barrow
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Development 127:933-44. 2000
    ..From these data a model is proposed to describe how Hoxa1, Hoxa2, Hoxb1, Krox20 (Egr2) and kreisler function together to pattern the early mouse hindbrain...
  65. pmc A dual role of erbB2 in myelination and in expansion of the schwann cell precursor pool
    A N Garratt
    Max Delbrück Centrum for Molecular Medicine, 13125 Berlin, Germany
    J Cell Biol 148:1035-46. 2000
    ..Here, we employ Cre-loxP technology to introduce erbB2 mutations late in Schwann cell development, using a Krox20-cre allele...
  66. ncbi Hindbrain patterning: Krox20 couples segmentation and specification of regional identity
    O Voiculescu
    Laboratoire de Biologie Moléculaire du Développement, INSERM U368, Ecole Normale Superieure, 46 rue d Ulm, 75230 Paris Cedex 05, France
    Development 128:4967-78. 2001
    We have previously demonstrated that inactivation of the Krox20 gene led to the disappearance of its segmental expression territories in the hindbrain, the rhombomeres (r) 3 and 5...
  67. ncbi Neural crest patterning: autoregulatory and crest-specific elements co-operate for Krox20 transcriptional control
    Julien Ghislain
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, 46 rue d Ulm, 75230 Paris Cedex 05, France
    Development 130:941-53. 2003
    ..b>Krox20, a transcription factor gene that plays a critical role in the development of the segmented hindbrain, is ..
  68. ncbi Integrity of developing spinal motor columns is regulated by neural crest derivatives at motor exit points
    Matthieu Vermeren
    MRC Centre for Developmental Neurobiology, Guy s Campus, King s College London, SE1 1UL, London, United Kingdom
    Neuron 37:403-15. 2003
    ..Thus, before the formation of a mature transitional zone at the MEP, BC cells maintain a cell-tight boundary that allows motor axons to cross but blocks neuron migration...
  69. ncbi The ontogeny of Krox-20 expression in brainstem and cerebellar neurons
    Shampa De
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90089, USA
    J Chem Neuroanat 25:213-26. 2003
    ....
  70. ncbi Regulation of the myelin gene periaxin provides evidence for Krox-20-independent myelin-related signalling in Schwann cells
    David B Parkinson
    Department of Anatomy and Developmental Biology, University College London, Gower Street, UK
    Mol Cell Neurosci 23:13-27. 2003
    We investigated the role of Krox-20 (Egr2), a transcription factor that regulates myelination, in controlling the myelin-associated protein periaxin...
  71. pmc Cell fate decisions within the mouse organizer are governed by graded Nodal signals
    Stephane D Vincent
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genes Dev 17:1646-62. 2003
    ..These findings conclusively demonstrate that graded Nodal/Smad2 signals govern allocation of the axial mesendoderm precursors that selectively give rise to the ADE and PCP mesoderm...
  72. ncbi Cryptic boundaries in roof plate and choroid plexus identified by intersectional gene activation
    Rajeshwar Awatramani
    Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Genet 35:70-5. 2003
    ..Our data suggest that the roof plate and choroid plexus may be formed of functional units that are capable of differentially organizing the generation of distinct neuronal cell types at different axial levels...
  73. ncbi The Ddx20/DP103 dead box protein represses transcriptional activation by Egr2/Krox-20
    Anne Lynn Gillian
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Biol Chem 279:9056-63. 2004
    The early growth response 2 (Egr2/Krox-20) transcription factor is essential for myelination of the peripheral nervous system and segmentation of the vertebrate hindbrain...
  74. ncbi Early growth response gene-2, a zinc-finger transcription factor, is required for full induction of clonal anergy in CD4+ T cells
    John E Harris
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 173:7331-8. 2004
    ..These data indicate that sustained Egr-2 expression is necessary to induce a full anergic state through the actions of genes regulated by this transcription factor...
  75. pmc Analysis of congenital hypomyelinating Egr2Lo/Lo nerves identifies Sox2 as an inhibitor of Schwann cell differentiation and myelination
    Nam Le
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8118, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 102:2596-601. 2005
    b>Egr2 is a transcription factor required for peripheral nerve myelination in rodents, and mutations in Egr2 are associated with congenital hypomyelinating neuropathy (CHN) in humans...
  76. pmc The class III POU domain protein Brn-1 can fully replace the related Oct-6 during schwann cell development and myelination
    Ralf P Friedrich
    Institut fur Biochemie, Universitat Erlangen, Fahrstrasse 17, 91054 Erlangen, Germany
    Mol Cell Biol 25:1821-9. 2005
    ..Similar to Oct-6, Brn-1 down-regulated its own expression at later stages of myelination. Thus, class III POU domain proteins can fully replace each other in Schwann cell development...
  77. ncbi Egr-2 and Egr-3 are negative regulators of T cell activation
    Meredith Safford
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Immunol 6:472-80. 2005
    ..Overexpression of Egr2 and Egr3 was associated with an increase in the E3 ubiquitin ligase Cbl-b and inhibition of T cell activation...
  78. ncbi The boundary cap: a source of neural crest stem cells that generate multiple sensory neuron subtypes
    Jens Hjerling-Leffler
    Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden
    Development 132:2623-32. 2005
    ..Our data suggests that BC cells comprise a source of multipotent sensory specified stem cells that persist throughout embryogenesis...
  79. ncbi Krox20 stimulates adipogenesis via C/EBPbeta-dependent and -independent mechanisms
    Zhu Chen
    Laboratory of Molecular Genetics, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Cell Metab 1:93-106. 2005
    b>Krox20 is a zinc finger-containing transcription factor that is abundantly expressed in adipose tissue. However, its role in fat cell differentiation has not been established...
  80. ncbi Assembly of the brainstem cochlear nuclear complex is revealed by intersectional and subtractive genetic fate maps
    Anna F Farago
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Neuron 50:205-18. 2006
    ..Together, these findings provide new platforms for investigating the development and evolution of auditory and cerebellar systems...
  81. ncbi Hoxa2- and rhombomere-dependent development of the mouse facial somatosensory map
    Franck Oury
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, UMR 7104, BP 10142, Communaute Urbaine de Strasbourg, 67404 Illkirch Cedex, France
    Science 313:1408-13. 2006
    ..Thus, Hoxa2- and rhombomere 3-dependent cues determine the whisker area map and are required for the assembly of the whisker-to-barrel somatosensory circuit...
  82. ncbi Peripheral myelin maintenance is a dynamic process requiring constant Krox20 expression
    Laurence Decker
    Institut National de la Sante et de la Recherche Medicale, U784, Ecole Normale Superieure, 75230 Paris Cedex 05, France
    J Neurosci 26:9771-9. 2006
    Onset of myelination in Schwann cells is governed by several transcription factors, including Krox20/Egr2, and mutations affecting Krox20 result in various human hereditary peripheral neuropathies, including congenital hypomyelinating ..
  83. pmc Neuropathy-associated Egr2 mutants disrupt cooperative activation of myelin protein zero by Egr2 and Sox10
    Scott E Leblanc
    University of Wisconsin Madison, WI 53706, USA
    Mol Cell Biol 27:3521-9. 2007
    Dominant mutations in the early growth response 2 (Egr2/Krox20) transactivator, a critical regulator of peripheral myelin development, have been associated with peripheral myelinopathies...
  84. pmc Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development
    Yves Benninger
    Institute of Cell Biology, Department of Biology, Eidgenossische Technische Hochschule Zurich, CH 8093 Zurich, Switzerland
    J Cell Biol 177:1051-61. 2007
    ..Our results indicate that although cdc42 is required for normal Schwann cell proliferation, rac1 regulates Schwann cell process extension and stabilization, allowing efficient radial sorting of axon bundles...
  85. ncbi Opposing effects of glucocorticoids and Wnt signaling on Krox20 and mineral deposition in osteoblast cultures
    Nathalie Leclerc
    Department of Biochemistry and Molecular Biology, Institute for Genetic Medicine, Keck School of Medicine at the University of Southern California, Los Angeles, California 90033, USA
    J Cell Biochem 103:1938-51. 2008
    b>Krox20 is expressed in osteoblasts and chondrocytes, and is required for trabecular bone formation during embryogenesis...
  86. pmc Opposing regulation of T cell function by Egr-1/NAB2 and Egr-2/Egr-3
    Sam Collins
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Eur J Immunol 38:528-36. 2008
    ..Overall, our data suggest that just as the Egr/NAB network of genes control cell fate in other systems, TCR-induced Egr-1, 2, 3 and NAB2 control the fate of antigen recognition in T cells...
  87. pmc Induction of early growth response gene 2 expression in the forebrain of mice performing an attention-set-shifting task
    D A DeSteno
    Department of Pharmacology, Columbia University, NY, NY 10032, USA
    Neuroscience 152:417-28. 2008
    ..These findings suggest a specific role of egr-2-mediated transcriptional activation in cognitive functions associated with attention...
  88. pmc Transcriptional regulation of adipogenesis by KLF4
    Kivanc Birsoy
    Laboratory of Molecular Genetics, Rockefeller University, New York, NY 10021, USA
    Cell Metab 7:339-47. 2008
    ..the C/EBPbeta (Cebpb) promoter as shown by chromatin immunoprecipitation and gel shift assays and, together with Krox20, cooperatively transactivates a C/EBPbeta reporter...
  89. pmc Early growth response gene 2 (Egr-2) controls the self-tolerance of T cells and prevents the development of lupuslike autoimmune disease
    Bo Zhu
    Institute of Cell and Molecular Science, Barts and London School of Medicine and Dentistry, University of London, London E1 2AT, England, UK
    J Exp Med 205:2295-307. 2008
    ..These results demonstrate that Egr-2 is an intrinsic regulator of effector T cells and controls the expansion of self-reactive T cells and development of autoimmune disease...
  90. doi Rostral hindbrain patterning involves the direct activation of a Krox20 transcriptional enhancer by Hox/Pbx and Meis factors
    Michel A Wassef
    INSERM, U784, Laboratoire de Génétique Moléculaire du Développement and 46 rue d Ulm, 75230 Paris, France
    Development 135:3369-78. 2008
    ..The morphogenesis of the vertebrate hindbrain involves the generation of metameric units called rhombomeres (r), and Krox20 encodes a transcription factor that is expressed in r3 and r5 and plays a major role in this segmentation process...
  91. pmc Congenital hypomyelinating neuropathy with lethal conduction failure in mice carrying the Egr2 I268N mutation
    Robert H Baloh
    Department of Neurology, and Hope Center for Neurological Diseases, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 29:2312-21. 2009
    ..Here, we describe the engineering and characterization of a mouse carrying the I268N mutation in Egr2, observed in patients with recessively inherited Charcot-Marie-Tooth (CMT) disease type 4E, which is predicted to ..
  92. pmc The tyrosine phosphatase Shp2 (PTPN11) directs Neuregulin-1/ErbB signaling throughout Schwann cell development
    Katja S Grossmann
    Neuroscience Department, Department of Cancer Research, Department of Cardiovascular Research, Max Delbrück Centrum for Molecular Medicine, Robert Rossle Strasse 10, Berlin, Germany
    Proc Natl Acad Sci U S A 106:16704-9. 2009
    ..Together, our genetic and biochemical analyses demonstrate that Shp2 is an essential component in the transduction of Nrg1/ErbB signals...
  93. doi Activation of Krox20 gene expression by Sox10 in myelinating Schwann cells
    Simone Reiprich
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen Nurnberg, 91054 Erlangen, Germany
    J Neurochem 112:744-54. 2010
    ..Sox10 is believed to influence myelination in Schwann cells by directly activating myelin genes and by inducing Krox20 as a pivotal regulator of peripheral myelination...
  94. doi Replacement of mouse Sox10 by the Drosophila ortholog Sox100B provides evidence for co-option of SoxE proteins into vertebrate-specific gene-regulatory networks through altered expression
    François Cossais
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen, Fahrstrasse 17, D 91054 Erlangen, Germany
    Dev Biol 341:267-81. 2010
    ....
  95. pmc Sox10 is required for Schwann cell identity and progression beyond the immature Schwann cell stage
    Markus Finzsch
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen Nurnberg, 91054 Erlangen, Germany
    J Cell Biol 189:701-12. 2010
    ..Schwann cells failed to develop beyond the immature stage and were unable to maintain identity. Thus, our study identifies a novel cause for peripheral neuropathies in patients with SOX10 mutations...
  96. doi Mouse schwann cells need both NRG1 and cyclic AMP to myelinate
    Peter Arthur-Farraj
    Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Glia 59:720-33. 2011
    ..They demonstrate unambiguously the promyelin effects of NRG1 in purified cells, and they show that the cAMP pathway determines whether NRG1 drives proliferation or induces myelin differentiation...
  97. pmc Regulation of the PMP22 gene through an intronic enhancer
    Erin A Jones
    Program in Cellular and Molecular Biology, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Neurosci 31:4242-50. 2011
    ..The transcription factor Egr2/Krox20 is required for induction of high level expression of Pmp22 in Schwann cells but its activation elements have not ..
  98. pmc Epigenetic silencing of the oncogenic miR-17-92 cluster during PU.1-directed macrophage differentiation
    Vit Pospisil
    Institute of Pathological Physiology and Center of Experimental Hematology, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
    EMBO J 30:4450-64. 2011
    ..1 induces the secondary determinant Egr2 which, in turn, directly represses miR-17-92 expression by recruiting histone demethylase Jarid1b leading to ..
  99. pmc Projections and interconnections of genetically defined serotonin neurons in mice
    Sun Jung Bang
    Department of Anesthesia Perioperative and Pain Medicine, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
    Eur J Neurosci 35:85-96. 2012
    ....
  100. pmc The transcription factors Egr2 and Egr3 are essential for the control of inflammation and antigen-induced proliferation of B and T cells
    Suling Li
    Bioscience, Brunel University, UK
    Immunity 37:685-96. 2012
    ..Here, we report that deletion of both transcription factors Egr2 and Egr3 in lymphocytes resulted in a lethal autoimmune syndrome with excessive serum proinflammatory cytokines but ..
  101. ncbi Zinc finger proteins: what we know and what we would like to know
    T el-Baradi
    Max Planck Institut fur Molekulare Genetik, Berlin, Germany
    Mech Dev 35:155-69. 1991

Research Grants5

  1. Role of Gbx2 and Otx2 in the mes-met organizer function
    James Li; Fiscal Year: 2003
    ..abstract_text> ..
  2. Mechanisms of Response to GnRH Receptor Signaling
    MARK LAWSON; Fiscal Year: 2005
    ..Isolation of actively translated and total mRNA from treated and control cells will allow identification and quantification of global changes in gene expression. ..
  3. Insulin Signaling in the Anterior Pituitary
    MARK LAWSON; Fiscal Year: 2006
    ....
  4. Resolving the nuclear fusion steps during yeast mating
    Patricia Melloy; Fiscal Year: 2006
    ..This information and the tools used can then be applied to other cell biological and gene regulation questions during other types of membrane fusion. ..
  5. Genetic Control of Schwann Cell Differentiation
    JOHN RUTLEDGE BERMINGHAM; Fiscal Year: 2011
    ..By understanding how the Lgi4 protein controls Schwann cell development, we will establish new avenues for the treatment of myelin disorders and nerve injury. ..