Erbin

Summary

Gene Symbol: Erbin
Description: Erbb2 interacting protein
Alias: 1700028E05Rik, Erbb2ip, mKIAA1225, erbin, densin-180-like protein, erbb2-interacting protein, protein LAP2
Species: mouse

Top Publications

  1. ncbi Erbin regulates mitogen-activated protein (MAP) kinase activation and MAP kinase-dependent interactions between Merlin and adherens junction protein complexes in Schwann cells
    Reshma Rangwala
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    J Biol Chem 280:11790-7. 2005
  2. pmc Erbin regulates NRG1 signaling and myelination
    Yanmei Tao
    Department of Neurology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Proc Natl Acad Sci U S A 106:9477-82. 2009
  3. ncbi ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor
    J P Borg
    U119 INSERM, Molecular Oncology, Marseille, France
    Nat Cell Biol 2:407-14. 2000
  4. pmc Erbin is required for myelination in regenerated axons after injury
    Chuan Liang
    Institute of Molecular Medicine and Genetics and Department of Neurology, Georgia Health Science University, Augusta, Georgia 30912, USA
    J Neurosci 32:15169-80. 2012
  5. doi LAP proteins are localized at the post-synaptic membrane of neuromuscular junctions and appear to modulate synaptic morphology and transmission
    Bojana Kravic
    Institut fur Biochemie, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    J Neurochem 139:381-395. 2016
  6. pmc Erbin is a novel substrate of the Sag-βTrCP E3 ligase that regulates KrasG12D-induced skin tumorigenesis
    Chuan Ming Xie
    Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109
    J Cell Biol 209:721-37. 2015
  7. pmc FHL2 switches MITF from activator to repressor of Erbin expression during cardiac hypertrophy
    Inbal Rachmin
    Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel Canada, Hebrew University Medical School, Jerusalem 91120, Israel
    Int J Cardiol 195:85-94. 2015
  8. doi Erbin interacts with c-Cbl and promotes tumourigenesis and tumour growth in colorectal cancer by preventing c-Cbl-mediated ubiquitination and down-regulation of EGFR
    Su Yao
    Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, People s Republic of China
    J Pathol 236:65-77. 2015
  9. pmc Role of Erbin in ErbB2-dependent breast tumor growth
    Yanmei Tao
    Department of Neuroscience and Regenerative Medicine and Department of Neurology, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912 Key Lab of Organ Development and Regeneration of Zhejiang Province, Institute of Developmental and Regenerative Biology, College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 310036, China
    Proc Natl Acad Sci U S A 111:E4429-38. 2014
  10. pmc Erbin is a negative modulator of cardiac hypertrophy
    Inbal Rachmin
    Department of Biochemistry and Molecular Biology, Institute for Medical Research Israel Canada, Hebrew University Medical School, Jerusalem 91120, Israel
    Proc Natl Acad Sci U S A 111:5902-7. 2014

Research Grants

Scientific Experts

  • RICK DOBROWSKY
  • Louis Reichardt
  • Dennis R Warner
  • J-P Borg
  • Lin Mei
  • Yanmei Tao
  • Sylvie Marchetto
  • Inbal Rachmin
  • Wen Cheng Xiong
  • Chengyong Shen
  • Bojana Kravic
  • Penggao Dai
  • Su Yao
  • Chuan Ming Xie
  • Roger S Y Foo
  • Gillian Kay
  • Eliahu Golomb
  • Ehud Razin
  • Dan Gilon
  • Sagi Tshori
  • Tian Ming Gao
  • Said Hashemolhosseini
  • Pan Pan
  • Chuan Liang
  • Luca Simeone
  • Jyothi Arikkath
  • Marie Josée Santoni
  • Christine McDonald
  • Reshma Rangwala
  • Alexander D Frick
  • Ralf Palmisano
  • Jasmin Jung
  • Veronika Redai
  • Danyil Huraskin
  • Min Guo
  • Lin Chen
  • Ronen Beeri
  • Zheng Quan Xiao
  • Pengfei Fang
  • Li Ming Song
  • Cheng Xing
  • Xing Ni Zhou
  • Peter Li Yiqing
  • Ying Li
  • Dongping Wei
  • Ping Zheng
  • Yi Sun
  • David E Fisher
  • Hua Wu
  • Xiao Fang Ying
  • Eden Amsalem
  • Mao De Lai
  • Jian Ming Li
  • Tong Shen
  • Lili Zhao
  • Hovav Nechushtan
  • Yu Hong Liu
  • Biao Wu
  • Xihui Liu
  • Yoav Smith
  • Chao Shi
  • Linlin Xu
  • Amit Oppenheim
  • Fanny Jaulin-Bastard
  • Jinghong Mei
  • Shiwen Luo
  • Ryan Bates
  • Kai Zhao
  • Noa Dagan
  • Wilfried Traoré
  • Yong Jun Chen
  • C Ryan Bates
  • Daehoon Lee
  • Zhengyi Luo
  • Zui Tan
  • Y Z Huang
  • Tatiana Cheusova
  • Muhammad Amir Khan
  • Marion Straubinger
  • Nancy Nalleweg
  • Yu Liu
  • Xin Liu
  • Inbal Israely
  • Wen C Xiong
  • Yasunori Ogura
  • Felicia F Chen
  • Vincent Ollendorff
  • Larry S Sherman
  • Patrick Lecine
  • Gabriel Nunez

Detail Information

Publications19

  1. ncbi Erbin regulates mitogen-activated protein (MAP) kinase activation and MAP kinase-dependent interactions between Merlin and adherens junction protein complexes in Schwann cells
    Reshma Rangwala
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    J Biol Chem 280:11790-7. 2005
    ..Here, we find that a novel PDZ protein, called erbin, binds directly to the merlin-binding partner, EBP0, and regulates adherens junction dissociation through a MAP ..
  2. pmc Erbin regulates NRG1 signaling and myelination
    Yanmei Tao
    Department of Neurology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Proc Natl Acad Sci U S A 106:9477-82. 2009
    ..However, little is known about regulatory mechanisms of NRG1 signaling. We show here that Erbin, a protein that contains leucine-rich repeats (LRR) and a PSD95-Dlg-Zol (PDZ) domain and that interacts ..
  3. ncbi ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor
    J P Borg
    U119 INSERM, Molecular Oncology, Marseille, France
    Nat Cell Biol 2:407-14. 2000
    ..We have identified a new PDZ protein we named ERBIN (ERBB2 interacting protein) that acts as an adaptor for the receptor ERBB2/HER2 in epithelia...
  4. pmc Erbin is required for myelination in regenerated axons after injury
    Chuan Liang
    Institute of Molecular Medicine and Genetics and Department of Neurology, Georgia Health Science University, Augusta, Georgia 30912, USA
    J Neurosci 32:15169-80. 2012
    ..In this study, we investigated the role of Erbin, a protein that interacts with ErbB2 in remyelination of injured nerves...
  5. doi LAP proteins are localized at the post-synaptic membrane of neuromuscular junctions and appear to modulate synaptic morphology and transmission
    Bojana Kravic
    Institut fur Biochemie, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    J Neurochem 139:381-395. 2016
    b>Erbin, Lano, Scribble, and Densin-180 belong to LAP (leucine-rich repeats and PDZ domain) adaptor proteins involved in cell signaling pathways...
  6. pmc Erbin is a novel substrate of the Sag-βTrCP E3 ligase that regulates KrasG12D-induced skin tumorigenesis
    Chuan Ming Xie
    Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109
    J Cell Biol 209:721-37. 2015
    ..Simultaneous one-allele deletion of the Erbin-encoding gene Erbb2ip partially rescued the phenotypes. Finally, we characterized Erbin as a novel substrate of SAG-βTrCP E3 ligase...
  7. pmc FHL2 switches MITF from activator to repressor of Erbin expression during cardiac hypertrophy
    Inbal Rachmin
    Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel Canada, Hebrew University Medical School, Jerusalem 91120, Israel
    Int J Cardiol 195:85-94. 2015
    ..We have previously described that microphthalmia-associated transcription factor (MITF) is a key regulator of cardiac hypertrophy, but its cardiac targets are still uncharacterized...
  8. doi Erbin interacts with c-Cbl and promotes tumourigenesis and tumour growth in colorectal cancer by preventing c-Cbl-mediated ubiquitination and down-regulation of EGFR
    Su Yao
    Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, People s Republic of China
    J Pathol 236:65-77. 2015
    ..Here, we found that Erbin, a member of the leucine-rich repeat and PDZ domain (LAP) family, plays a key role in EGFR signalling...
  9. pmc Role of Erbin in ErbB2-dependent breast tumor growth
    Yanmei Tao
    Department of Neuroscience and Regenerative Medicine and Department of Neurology, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912 Key Lab of Organ Development and Regeneration of Zhejiang Province, Institute of Developmental and Regenerative Biology, College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 310036, China
    Proc Natl Acad Sci U S A 111:E4429-38. 2014
    ..We report here that Erbin, an ErbB2-interacting protein that was thought to act as an antitumor factor, is specifically expressed in mammary ..
  10. pmc Erbin is a negative modulator of cardiac hypertrophy
    Inbal Rachmin
    Department of Biochemistry and Molecular Biology, Institute for Medical Research Israel Canada, Hebrew University Medical School, Jerusalem 91120, Israel
    Proc Natl Acad Sci U S A 111:5902-7. 2014
    b>ErbB2 interacting protein (Erbin) is a widely expressed protein and participates in inhibition of several intracellular signaling pathways. Its mRNA has been found to be present in relatively high levels in the heart...
  11. pmc Differential expression of neuregulin-1 isoforms and downregulation of erbin are associated with Erb B2 receptor activation in diabetic peripheral neuropathy
    Pan Pan
    Department of Pharmacology and Toxicology, University of Kansas, Lawrence, KS, USA
    Acta Neuropathol Commun 1:39. 2013
    ..Alternatively, Erb B2 activity can be negatively regulated by association with the Erb B2-interacting protein, erbin. Since the effect of diabetes on the expression of NRG1 isoforms and erbin in peripheral nerve are unknown, the ..
  12. doi Erbin interacts with TARP γ-2 for surface expression of AMPA receptors in cortical interneurons
    Yanmei Tao
    Institute of Developmental and Regenerative Biology, College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, China
    Nat Neurosci 16:290-9. 2013
    ..Here we demonstrate that Erbin is specifically expressed in cortical inhibitory neurons...
  13. doi Identification of Erbin interlinking MuSK and ErbB2 and its impact on acetylcholine receptor aggregation at the neuromuscular junction
    Luca Simeone
    Institut fur Biochemie, Universitat Erlangen Nurnberg, D 91054 Erlangen, Germany
    J Neurosci 30:6620-34. 2010
    b>Erbin, a binding partner of ErbB2, was identified as the first member of the LAP family of proteins...
  14. pmc Erbin controls dendritic morphogenesis by regulating localization of delta-catenin
    Jyothi Arikkath
    Department of Physiology, University of California, San Francisco, San Francisco, California 94158, USA
    J Neurosci 28:7047-56. 2008
    The LAP [leucine-rich and postsynaptic density-95/Discs large/zona occludens-1 (PDZ)] protein erbin and delta-catenin, a component of the cadherin-catenin cell adhesion complex, are highly expressed in neurons and associate through PDZ-..
  15. ncbi Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex
    Penggao Dai
    Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, 30912, USA
    J Biol Chem 281:927-33. 2006
    b>Erbin is a member of the LAP (leucine-rich repeat (LRR) and PDZ domain) family. It inhibits Ras-mediated activation of ERK in response to growth factors...
  16. ncbi A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling
    Christine McDonald
    Department of Pathology, University of Michigan Medical School and Comprehensive Cancer Center, Ann Arbor, Michigan, 48109, USA
    J Biol Chem 280:40301-9. 2005
    ..We performed a biochemical screen to discover potential regulators of Nod2 and identified Erbin, a protein involved in cell polarity, receptor localization, and regulation of the mitogen-activated protein ..
  17. ncbi Identification of three novel Smad binding proteins involved in cell polarity
    Dennis R Warner
    University of Louisville Birth Defects Center, Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville School of Dentistry, 501 South Preston Street, Suite 301, Louisville, KY 40292, USA
    FEBS Lett 539:167-73. 2003
    ..Three proteins (Erbin, Par-3, and Dishevelled) were identified that share several similar structural and functional characteristics...
  18. ncbi Interaction between Erbin and a Catenin-related protein in epithelial cells
    Fanny Jaulin-Bastard
    U119 INSERM, Molecular Oncology, Institut Paoli Calmettes, Molecular Pharmacology, 27 boulevard Lei Roure 13009 Marseille, France
    J Biol Chem 277:2869-75. 2002
    ..We previously described Erbin as a mammalian LET-413 homologue interacting with ERBB2/HER2, an epidermal growth factor receptor family member...
  19. ncbi Erbin is a protein concentrated at postsynaptic membranes that interacts with PSD-95
    Y Z Huang
    Departments of Neurobiology, University of Alabama at Birmingham, School of Medicine, Birmingham, Alabama 35294, USA
    J Biol Chem 276:19318-26. 2001
    ..Using as bait the ErbB2 C terminus, we identified Erbin, another PDZ domain-containing protein that interacts specifically with ErbB2...

Research Grants6

  1. MECHANISMS OF NEUROTROPHIN RECEPTOR CROSSTALK
    RICK DOBROWSKY; Fiscal Year: 2002
    ..These studies will determine if compartmentalization of the receptors into CRDs is in fact necessary, and if the CRD content of cholesterol and sphingomyelin affects the localization of Trk to CRDs, and compromises signaling. ..
  2. REGULATION OF P75NTR SIGNALING IN CAVEOLAE
    RICK DOBROWSKY; Fiscal Year: 2003
    ..The expected outcome of these studies is that we will provide important and novel information relevant to our understanding of signal transduction pathways operative in neurodegenerative processes. ..
  3. Oxidative Stress and the Mitochondrial Proteome in Diabetic Neuropathy
    RICK DOBROWSKY; Fiscal Year: 2009
    ..abstract_text> ..
  4. Nephronectin-dependent signaling in kidney development
    Louis Reichardt; Fiscal Year: 2007
    ..We will attempt to determine which of these pathways are activated by nephronectin-engagement of a8bl and which are compromised by the absence of a8bl in the metanephric mesenchyme. ..
  5. Molecular & Cellular Neurobiology 2008 Gordon Research Conference
    Louis Reichardt; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  6. Integrin Signaling in Nervous System Development
    Louis Reichardt; Fiscal Year: 2009
    ..They should also contribute to our understanding of the signaling pathways through which an important family of axon guidance molecules controls axon growth, branching and guidance. ..