Fgfr2

Summary

Gene Symbol: Fgfr2
Description: fibroblast growth factor receptor 2
Alias: AU043015, AW556123, Bek, Fgfr-2, Fgfr-7, Fgfr7, KGFR, KGFRTr, svs, fibroblast growth factor receptor 2, keratinocyte growth factor receptor
Species: mouse

Top Publications

  1. ncbi Gene expression profiling of differentiating embryonic stem cells expressing dominant negative fibroblast growth factor receptor 2
    Renata Meszaros
    Department of Experimental Medical Science, Division for Cell and Matrix Biology, Lund University, Lund, Sweden
    Matrix Biol 26:197-205. 2007
  2. ncbi Mutations in fibroblast growth factor receptor 2 and fibroblast growth factor receptor 3 genes associated with human gastric and colorectal cancers
    J H Jang
    Laboratory of Cell Biology, Cancer Research Institute, Seoul National University College of Medicine, Seoul 110 744, Korea
    Cancer Res 61:3541-3. 2001
  3. pmc FGF10 controls the patterning of the tracheal cartilage rings via Shh
    Frederic G Sala
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    Development 138:273-82. 2011
  4. ncbi Fibroblast growth factor receptor 2-IIIb acts upstream of Shh and Fgf4 and is required for limb bud maintenance but not for the induction of Fgf8, Fgf10, Msx1, or Bmp4
    J M Revest
    Imperial Cancer Research Fund, Lincoln s Inn Fields, London, WC2A 3PX, United Kingdom
    Dev Biol 231:47-62. 2001
  5. ncbi Gli3-mediated somitic Fgf10 expression gradients are required for the induction and patterning of mammary epithelium along the embryonic axes
    Jacqueline M Veltmaat
    The Saban Research Institute of Childrens Hospital Los Angeles University of Southern California, Developmental Biology Program, Los Angeles, CA 90027, USA
    Development 133:2325-35. 2006
  6. pmc Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene
    T Miki
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 89:246-50. 1992
  7. pmc FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis
    Norihiko Ohbayashi
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo ku, Kyoto 606 8501, Japan
    Genes Dev 16:870-9. 2002
  8. ncbi Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth
    Kai Yu
    Department of Molecular Biology and Pharmacology, Washington University Medical School, Campus Box 8103, 660 S Euclid Avenue, St Louis, Missouri 63110, USA
    Development 130:3063-74. 2003
  9. pmc Early onset of craniosynostosis in an Apert mouse model reveals critical features of this pathology
    Greg Holmes
    Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA
    Dev Biol 328:273-84. 2009
  10. pmc Signaling through BMP receptors promotes respiratory identity in the foregut via repression of Sox2
    Eric T Domyan
    Laboratory of Genetics, University of Wisconsin Madison, Madison, WI 53706, USA
    Development 138:971-81. 2011

Research Grants

  1. ETHANOL, RETINOIDS, AND CONGENITAL HEART MALFORMATIONS
    Janee Gelineau van Waes; Fiscal Year: 2003
  2. Somatic support cell function in gonad development
    GERRIT BOUMA; Fiscal Year: 2006
  3. Regulation of parietal bone differentiation
    Venkatesh Govindarajan; Fiscal Year: 2007
  4. Eda/Edar Regulation of Embryonic SMG Development
    Tina Jaskoll; Fiscal Year: 2007
  5. PROTEOMIC MAPPING OF MYELIN AND ITS MEMBRANE SUBDOMAINS
    Rashmi Bansal; Fiscal Year: 2009
  6. Mechanisms of endoderm specification along the A-P axis.
    James M Wells; Fiscal Year: 2010
  7. Molecular Regulation of Ocular Gland Development
    Venkatesh Govindarajan; Fiscal Year: 2010

Detail Information

Publications183 found, 100 shown here

  1. ncbi Gene expression profiling of differentiating embryonic stem cells expressing dominant negative fibroblast growth factor receptor 2
    Renata Meszaros
    Department of Experimental Medical Science, Division for Cell and Matrix Biology, Lund University, Lund, Sweden
    Matrix Biol 26:197-205. 2007
    ..Fibroblast growth factor receptors (mainly FGFR2) are involved in the first differentiation events during early mammalian embryogenesis...
  2. ncbi Mutations in fibroblast growth factor receptor 2 and fibroblast growth factor receptor 3 genes associated with human gastric and colorectal cancers
    J H Jang
    Laboratory of Cell Biology, Cancer Research Institute, Seoul National University College of Medicine, Seoul 110 744, Korea
    Cancer Res 61:3541-3. 2001
    ..Here we report two identical mutations in FGFR2 that cause craniosynostosis syndromes, Crouzon, Apert, and Pfeiffer in gastric carcinoma...
  3. pmc FGF10 controls the patterning of the tracheal cartilage rings via Shh
    Frederic G Sala
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    Development 138:273-82. 2011
    ..We propose that disturbed balances of Fgf10 and Shh may explain a subset of human tracheomalacia without tracheo-esophageal fistula or tracheal atresia...
  4. ncbi Fibroblast growth factor receptor 2-IIIb acts upstream of Shh and Fgf4 and is required for limb bud maintenance but not for the induction of Fgf8, Fgf10, Msx1, or Bmp4
    J M Revest
    Imperial Cancer Research Fund, Lincoln s Inn Fields, London, WC2A 3PX, United Kingdom
    Dev Biol 231:47-62. 2001
    Mice deficient for FgfR2-IIIb were generated by placing translational stop codons and an IRES-LacZ cassette into exon IIIb of FgfR2...
  5. ncbi Gli3-mediated somitic Fgf10 expression gradients are required for the induction and patterning of mammary epithelium along the embryonic axes
    Jacqueline M Veltmaat
    The Saban Research Institute of Childrens Hospital Los Angeles University of Southern California, Developmental Biology Program, Los Angeles, CA 90027, USA
    Development 133:2325-35. 2006
    ..We propose that the intra-somitic Fgf10 gradient, together with ventral elongation of the somites, determines the correct dorsoventral position of mammary epithelium along the flank...
  6. pmc Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene
    T Miki
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 89:246-50. 1992
    Expression cDNA cloning and structural analysis of the human keratinocyte growth factor receptor (KGFR) revealed identity with one of the fibroblast growth factor (FGF) receptors encoded by the bek gene (FGFR-2), except for a divergent ..
  7. pmc FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis
    Norihiko Ohbayashi
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo ku, Kyoto 606 8501, Japan
    Genes Dev 16:870-9. 2002
    ..Conversely, chondrocyte proliferation and the number of differentiated chondrocytes are increased. Therefore, FGF18 appears to regulate cell proliferation and differentiation positively in osteogenesis and negatively in chondrogenesis...
  8. ncbi Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth
    Kai Yu
    Department of Molecular Biology and Pharmacology, Washington University Medical School, Campus Box 8103, 660 S Euclid Avenue, St Louis, Missouri 63110, USA
    Development 130:3063-74. 2003
    Human craniosynostosis syndromes, resulting from activating or neomorphic mutations in fibroblast growth factor receptor 2 (FGFR2), underscore an essential role for FGFR2 signaling in skeletal development...
  9. pmc Early onset of craniosynostosis in an Apert mouse model reveals critical features of this pathology
    Greg Holmes
    Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA
    Dev Biol 328:273-84. 2009
    ..We have reassessed coronal suture fusion in an Apert Fgfr2 (S252W) mouse model...
  10. pmc Signaling through BMP receptors promotes respiratory identity in the foregut via repression of Sox2
    Eric T Domyan
    Laboratory of Genetics, University of Wisconsin Madison, Madison, WI 53706, USA
    Development 138:971-81. 2011
    ....
  11. ncbi FGF-, BMP- and Shh-mediated signalling pathways in the regulation of cranial suture morphogenesis and calvarial bone development
    H J Kim
    Institute of Biotechnology, University of Helsinki, Finland
    Development 125:1241-51. 1998
    ..Msx1 and Msx2 were expressed in the sutural mesenchyme and the dura mater. FGFR2(BEK), as well as Bmp2 and Bmp4, were intensely expressed in the osteogenic fronts and Bmp4 also in the mesenchyme ..
  12. ncbi Tbx5 is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo
    Pooja Agarwal
    Programmes in Cardiovascular Research and Developmental Biology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada
    Development 130:623-33. 2003
    ..These data suggest common pathways for the differentiation and growth of embryonic structures downstream of T-box genes...
  13. ncbi Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination
    Jennifer Schmahl
    Department of Cell Biology, Duke University, Durham, NC 27710, USA
    Development 131:3627-36. 2004
    ..of cells that give rise to Sertoli progenitors; and (2) for the nuclear localization of an FGF receptor (FGFR2) in Sertoli cell precursors...
  14. ncbi Responsiveness of developing dental tissues to fibroblast growth factors: expression of splicing alternatives of FGFR1, -2, -3, and of FGFR4; and stimulation of cell proliferation by FGF-2, -4, -8, and -9
    P Kettunen
    Developmental Biology Programme, University of Helsinki, Finland
    Dev Genet 22:374-85. 1998
    ..The IIIc splice form of FGFR1 was expressed both in epithelium and mesenchyme whereas FGFR2 IIIc was confined to the mesenchymal cells of the dental follicle...
  15. pmc A splicing switch and gain-of-function mutation in FgfR2-IIIc hemizygotes causes Apert/Pfeiffer-syndrome-like phenotypes
    M K Hajihosseini
    Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Proc Natl Acad Sci U S A 98:3855-60. 2001
    ..Here we show that a heterozygotic abrogation of FgfR2-exon 9 (IIIc) in mice causes a splicing switch, resulting in a gain-of-function mutation...
  16. ncbi A genetic mechanism for cecal atresia: the role of the Fgf10 signaling pathway
    T J Fairbanks
    Developmental Biology Program, Children s Hospital Los Angeles, 4650 Sunset Boulevard, Smith Research Tower 804, Mail stop 100, Los Angeles, CA 90027, USA
    J Surg Res 120:201-9. 2004
    ..Fgf10 is known to serve a key role in budding morphogenesis; however, little is known about its role in the development of this transitional structure. Here we evaluate the effect of Fgf10/Fgfr2b invalidation on the developing cecum...
  17. pmc FGF-regulated Etv genes are essential for repressing Shh expression in mouse limb buds
    Zhen Zhang
    Laboratory of Genetics, University of Wisconsin Madison, Madison, WI 53706, USA
    Dev Cell 16:607-13. 2009
    ..This finding elucidates a novel aspect of the mechanism coordinating limb development along the A-P and P-D axes...
  18. pmc beta-Catenin promotes respiratory progenitor identity in mouse foregut
    Kelley S Harris-Johnson
    Laboratory of Genetics and Division of Pharmaceutical Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 106:16287-92. 2009
    ..Our findings reveal an early role for beta-Catenin in the establishment of respiratory progenitors in mouse foregut endoderm...
  19. pmc Attenuation of signaling pathways stimulated by pathologically activated FGF-receptor 2 mutants prevents craniosynostosis
    V P Eswarakumar
    Department of Pharmacology and Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 103:18603-8. 2006
    ....
  20. pmc Histone-acetylated control of fibroblast growth factor receptor 2 intron 2 polymorphisms and isoform splicing in breast cancer
    Xuegong Zhu
    Department of Medicine, and the Endocrine Oncology Site Group, Princess Margaret Hospital, Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada M5G 2M9
    Mol Endocrinol 23:1397-405. 2009
    ..In particular, the disease-predisposing allele of FGFR2 is inherited as a 7.5-kb region within intron 2 that harbors eight single nucleotide polymorphisms...
  21. ncbi Fibroblast growth factor signalling in the hair growth cycle: expression of the fibroblast growth factor receptor and ligand genes in the murine hair follicle
    T A Rosenquist
    Department of Anatomy, University of California at San Francisco 94143 0452, USA
    Dev Dyn 205:379-86. 1996
    ..During anagen, we detected Fgfr1 RNA in the dermal papilla, Fgfr2 RNA in hair matrix cells near the dermal papilla, Fgfr3 RNA in pre-cuticle cells in the periphery of the hair bulb,..
  22. ncbi Fibroblast growth factor 10 is required for survival and proliferation but not differentiation of intestinal epithelial progenitor cells during murine colon development
    Frederic G Sala
    UMR144 CNRS Institut Curie, 75248 Paris Cedex 05, France
    Dev Biol 299:373-85. 2006
    ..We found that Fgf10 is expressed in the mesenchyme of the distal colon, while its main receptor Fgfr2-IIIb is expressed throughout the entire intestinal epithelium...
  23. pmc Beyond the closed suture in apert syndrome mouse models: evidence of primary effects of FGFR2 signaling on facial shape at birth
    Neus Martínez-Abadías
    Department of Anthropology, Pennsylvania State University, University Park, Pennsylvania 16803, USA
    Dev Dyn 239:3058-71. 2010
    Apert syndrome is a congenital disorder caused mainly by two neighboring mutations on fibroblast growth factor receptor 2 (FGFR2)...
  24. ncbi Identification of fibroblast growth factor 9 (FGF9) as a high affinity, heparin dependent ligand for FGF receptors 3 and 2 but not for FGF receptors 1 and 4
    D Hecht
    Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel
    Growth Factors 12:223-33. 1995
    ..FGF9 can also bind, albeit with a lower affinity, to FGFR2 but does not bind FGFR1 or FGFR4...
  25. ncbi An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis
    L De Moerlooze
    Imperial Cancer Research Fund, Lincoln s Inn Fields, London WC2A 3PX, UK
    Development 127:483-92. 2000
    The fibroblast growth factor receptor 2 gene is differentially spliced to encode two transmembrane tyrosine kinase receptor proteins that have different ligand-binding specificities and exclusive tissue distributions...
  26. ncbi Prenatal, but not postnatal, inhibition of fibroblast growth factor receptor signaling causes emphysema
    Isamu Hokuto
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 278:415-21. 2003
    ..5 but did not alter alveolarization when expressed after birth. Although FGF signaling was required for branching morphogenesis early in lung development, postnatal alveolarization was not influenced by FGFR-HFc...
  27. ncbi Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung
    Weiguo Shu
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Biol 283:226-39. 2005
    ..Thus, Wnt/beta-catenin signaling is a critical upstream regulator of proximal-distal patterning in the lung, in part, through regulation of N-myc, BMP4, and FGF signaling...
  28. pmc Three-dimensional imaging reveals ureteric and mesenchymal defects in Fgfr2-mutant kidneys
    Sunder Sims-Lucas
    Rangos Research Center, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15201, USA
    J Am Soc Nephrol 20:2525-33. 2009
    ..Here, we used in vivo three-dimensional analysis to study renal development in mice lacking fibroblast growth factor receptor 2 in the ureteric bud (Fgfr2(UB-/-)) and in littermate controls...
  29. pmc Independent roles of Fgfr2 and Frs2alpha in ureteric epithelium
    Sunder Sims-Lucas
    Rangos Research Center, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15201, USA
    Development 138:1275-80. 2011
    Mice with conditional deletion of fibroblast growth factor receptor 2 (Fgfr2) in the ureteric bud using a Hoxb7cre line (Fgfr2(UB-/-)) develop severe ureteric branching defects; however, ureteric deletion of fibroblast growth factor ..
  30. pmc Fibroblast growth factor receptor-mediated activation of AKT-β-catenin-CBP pathway regulates survival and proliferation of murine hepatoblasts and hepatic tumor initiating stem cells
    Nirmala Mavila
    Saban Research Institute, Children s Hospital Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 7:e50401. 2012
    ....
  31. ncbi Apoptosis, proliferation and gene expression patterns in mouse developing tongue
    Xuguang Nie
    Section of Anatomy and Cell Biology, Department of Biomedicine, University of Bergen, Jonas Lies V91, 5009, Bergen, Norway
    Anat Embryol (Berl) 210:125-32. 2005
    ..Fgf2 was seen in the tongue muscles at the late embryonic and postnatal stages. These results suggest that Bmp and Fgf signalling regulates tongue development at multiple stages, possibly related to proliferation and differentiation...
  32. pmc Genetic mosaic analysis reveals FGF receptor 2 function in terminal end buds during mammary gland branching morphogenesis
    Pengfei Lu
    Department of Anatomy and Program in Developmental Biology, University of California at San Francisco, San Francisco, CA 94143 0452, USA
    Dev Biol 321:77-87. 2008
    ..study, we employed a genetic mosaic analysis based on Cre-mediated recombination to investigate FGF receptor 2 (Fgfr2) function in the postnatal mammary gland...
  33. pmc Neutrophil MMP-9 proenzyme, unencumbered by TIMP-1, undergoes efficient activation in vivo and catalytically induces angiogenesis via a basic fibroblast growth factor (FGF-2)/FGFR-2 pathway
    Veronica C Ardi
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 284:25854-66. 2009
    ....
  34. pmc Fibroblast growth factor receptors 1 and 2 in keratinocytes control the epidermal barrier and cutaneous homeostasis
    Jingxuan Yang
    Department of Biology, Institute of Cell Biology, Eidgenossische Technische Hochschule Zurich, 8093 Zurich, Switzerland
    J Cell Biol 188:935-52. 2010
    ..Loss of the IIIb splice variants of FGFR1 and FGFR2 in keratinocytes caused progressive loss of skin appendages, cutaneous inflammation, keratinocyte ..
  35. pmc Signaling from fibroblast growth factor receptor 2 in immature hematopoietic cells facilitates donor hematopoiesis after intra-bone marrow-bone marrow transplantation
    Akio Shigematsu
    First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan
    Stem Cells Dev 19:1679-86. 2010
    ..In this report, we examined the effects of FGFR2 signaling on hematopoiesis in immature hematopoietic cells, using mutant mice in which a constitutively active ..
  36. doi Identification and characterization of an inhibitory fibroblast growth factor receptor 2 (FGFR2) molecule, up-regulated in an Apert Syndrome mouse model
    Lee M Wheldon
    School of Biosciences, University of Birmingham, Edgbaston B15 2TT, UK
    Biochem J 436:71-81. 2011
    ..congenital disease composed of skeletal, visceral and neural abnormalities, caused by dominant-acting mutations in FGFR2 [FGF (fibroblast growth factor) receptor 2]...
  37. pmc Lacrimal gland development and Fgf10-Fgfr2b signaling are controlled by 2-O- and 6-O-sulfated heparan sulfate
    Xiuxia Qu
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 286:14435-44. 2011
    ..To our knowledge, this is the first study to show that simultaneous deletion of Hs2st and Hs6st exhibits profound FGF signaling defects in mammalian development...
  38. ncbi Retinoic acid selectively regulates Fgf10 expression and maintains cell identity in the prospective lung field of the developing foregut
    Tushar J Desai
    Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
    Dev Biol 273:402-15. 2004
    ..Our study supports RA as an essential regulator of gene expression and cellular activities during primary bud formation...
  39. pmc Role of fibroblast growth factor receptors 1 and 2 in the ureteric bud
    Haotian Zhao
    Center for Human and Molecular Genetics, Columbus Children s Research Institute, 700 Children s Drive, Columbus, OH 43205, USA
    Dev Biol 276:403-15. 2004
    Fibroblast growth receptors (FGFRs) consist of four signaling family members. Mice with deletions of fgfr1 or fgfr2 are embryonic lethal prior to the onset of kidney development...
  40. ncbi Foxl2 is required for commitment to ovary differentiation
    Chris Ottolenghi
    Laboratory of Genetics, National Institute on Aging, Baltimore, MD 21224, USA
    Hum Mol Genet 14:2053-62. 2005
    ..This suggests the possible continued involvement of sex-determining genes in maintaining ovarian function throughout female reproductive life...
  41. pmc The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development
    Richard Grose
    Centre for Tumour Biology, Institute of Cancer, Bart s and The London, Queen Mary s School of Medicine and Dentistry, London, UK
    EMBO J 26:1268-78. 2007
    The epithelial isoform of fibroblast growth factor receptor 2 (Fgfr2b) is essential for embryogenesis, and Fgfr2b-null mice die at birth...
  42. ncbi The IIIc alternative of Fgfr2 is a positive regulator of bone formation
    Vereragavan P Eswarakumar
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot Israel
    Development 129:3783-93. 2002
    Fibroblast growth factor receptor type 2 (FGFR2) plays major roles in development. Like FGFR1 and FGFR3, it exists as two splice variants, IIIb and IIIc...
  43. pmc FGF9 regulates early hypertrophic chondrocyte differentiation and skeletal vascularization in the developing stylopod
    Irene H Hung
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, Campus Box 8103, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 307:300-13. 2007
    ..In developing stylopod elements, FGF9 promotes chondrocyte hypertrophy at early stages and regulates vascularization of the growth plate and osteogenesis at later stages of skeletal development...
  44. pmc The FGF system has a key role in regulating vascular integrity
    Masahiro Murakami
    Angiogenesis Research Center and Section of Cardiology, Dartmouth Medical School, Lebanon, New Hampshire, USA
    J Clin Invest 118:3355-66. 2008
    ..Thus, FGF signaling plays a key role in the maintenance of vascular integrity...
  45. pmc Keratinocyte growth factor is an important endogenous mediator of hair follicle growth, development, and differentiation. Normalization of the nu/nu follicular differentiation defect and amelioration of chemotherapy-induced alopecia
    D M Danilenko
    Department of Experimental Pathology, Amgen Inc, Thousand Oaks, California 91320 1789, USA
    Am J Pathol 147:145-54. 1995
    ..Because KGF induces marked proliferation of keratinocytes, and both KGF and KGF receptor (KGFR) mRNA are expressed at high levels in skin, we sought to localize KGF and KGFR in skin by in situ hybridization...
  46. ncbi Fibroblast growth factor receptor 3 is a negative regulator of bone growth
    C Deng
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, 02115, USA
    Cell 84:911-21. 1996
    ..In light of these mouse results, certain human disorders, such as achondroplasia, can be interpreted as gain-of-function mutations that activate the fundamentally negative growth control exerted by the FGFR-3 kinase...
  47. ncbi Fgfr2 and osteopontin domains in the developing skull vault are mutually exclusive and can be altered by locally applied FGF2
    S Iseki
    Department of Human Anatomy, Oxford, UK
    Development 124:3375-84. 1997
    Mutations in the human fibroblast growth factor receptor type 2 (FGFR2) gene cause craniosynostosis, particularly affecting the coronal suture...
  48. pmc Impaired cerebral cortex development and blood pressure regulation in FGF-2-deficient mice
    R Dono
    EMBL, Heidelberg, Germany
    EMBO J 17:4213-25. 1998
    ..The observed autonomic dysfunction in FGF-2-deficient adult mice uncovers more general roles in neural development and function...
  49. ncbi Fgfr1 and Fgfr2 have distinct differentiation- and proliferation-related roles in the developing mouse skull vault
    S Iseki
    Department of Human Anatomy and Genetics, South Parks Road, Oxford OX1 3QX, UK
    Development 126:5611-20. 1999
    ..growth factor receptors (FGFRs) play major roles in skeletogenesis, and activating mutations of the human FGFR1, FGFR2 and FGFR3 genes cause premature fusion of the skull bones (craniosynostosis)...
  50. ncbi Integration of FGF and TWIST in calvarial bone and suture development
    D P Rice
    Institute of Biotechnology and Institute of Dentistry, PO Box 56, Finland
    Development 127:1845-55. 2000
    ..The IIIc splice variants of Fgfr1-Fgfr3 as well as the IIIb variant of Fgfr2 being expressed by differentiating osteoblasts at the osteogenic fronts (E15)...
  51. ncbi Fibroblast growth factor receptor 2 (Fgfr2) plays an important role in eyelid and skin formation and patterning
    C Li
    Genetics Development and Disease Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Dev Dyn 222:471-83. 2001
    ..Using embryos lacking the Fgfr2 Ig domain III (Fgfr2(DeltaIII/DeltaIII)) generated by tetraploid rescue and chimeric embryo formation approaches, ..
  52. ncbi Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus
    Michelle Y Cheng
    Department of Pharmacology, University of California, Irvine, California 92697, USA
    Nature 417:405-10. 2002
    ..The high expression of PKR2 mRNA within the SCN and the positive feedback of PK2 on its own transcription through activation of PKR2 suggest that PK2 may also function locally within the SCN to synchronize output...
  53. ncbi A Non-sequence-specific double-stranded RNA structural element regulates splicing of two mutually exclusive exons of fibroblast growth factor receptor 2 (FGFR2)
    Stephanie J Muh
    Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6144, USA
    J Biol Chem 277:50143-54. 2002
    Alternative splicing of fibroblast growth factor receptor 2 (FGFR2) mutually exclusive exons IIIb and IIIc represents a tightly regulated and functionally relevant example of post-transcriptional gene regulation...
  54. ncbi Gene expression profiles of mouse submandibular gland development: FGFR1 regulates branching morphogenesis in vitro through BMP- and FGF-dependent mechanisms
    Matthew P Hoffman
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, MSC 4370, Bethesda, MD 20892 4370, USA
    Development 129:5767-78. 2002
    ..Taken together, our results suggest specific FGFs and BMPs play reciprocal roles in regulating branching morphogenesis and FGFR1 signaling plays a central role by regulating both FGF and BMP expression...
  55. ncbi The IIIb isoform of fibroblast growth factor receptor 2 is required for proper growth and branching of pancreatic ductal epithelium but not for differentiation of exocrine or endocrine cells
    Mari Anne Pulkkinen
    Biomedicum Helsinki, Program for Developmental and Reproductive Biology and Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland
    Mech Dev 120:167-75. 2003
    ..Recently it was shown that Fgf10, a major ligand for the IIIb isoform of fibroblast growth factor receptor 2 (Fgfr2b), has an important regulatory role in early pancreas development...
  56. ncbi Expression of FGF receptors 1, 2, 3 in the embryonic and postnatal mouse brain compared with Pdgfralpha, Olig2 and Plp/dm20: implications for oligodendrocyte development
    Rashmi Bansal
    Department of Neuroscience, University of Connecticut Medical School, Farmington, Conn 06030 3401, USA
    Dev Neurosci 25:83-95. 2003
    Fibroblast growth factors (FGF) receptors FgfR1, FgfR2 and FgfR3 are differentially regulated during oligodendrocyte (OL) maturation in vitro: FgfR3 is expressed by OL progenitors whereas FgfR2 is expressed by differentiated OLs [Mol ..
  57. ncbi Fgf10 maintains notch activation, stimulates proliferation, and blocks differentiation of pancreatic epithelial cells
    Alan Hart
    Umeå Center for Molecular Medicine, University of Umea, Umea, Sweden
    Dev Dyn 228:185-93. 2003
    ..Together, our data suggest a role for FGF10/FGFR2b signalling in regulation of pancreatic cell proliferation and differentiation and that FGF10/FGFR2b signalling affects the Notch-mediated lateral inhibition pathway...
  58. ncbi Differential role of FGF9 on epithelium and mesenchyme in mouse embryonic lung
    Pierre Marie del Moral
    Developmental Biology Program, Saban Research Institute of Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
    Dev Biol 293:77-89. 2006
    ..Our work shows for the first time that FGF9 acts on the epithelium involving FGFR2b to control its proliferation but not its differentiation and contributes to the regulation of canonical Wnt signaling in the epithelium...
  59. pmc Sprouty genes control diastema tooth development via bidirectional antagonism of epithelial-mesenchymal FGF signaling
    Ophir D Klein
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California, San Francisco, San Francisco, California 94143, USA
    Dev Cell 11:181-90. 2006
    ....
  60. ncbi Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lung
    Stijn P De Langhe
    Developmental Biology Program, Department of Surgery, Saban Research Institute of Childrens Hospital Los Angeles, CA 90027, USA
    Dev Biol 299:52-62. 2006
    ..Our work unravels part of the complex interactions that govern normal lung development and may be pertinent to understanding the basis of respiratory defects in Apert syndrome...
  61. ncbi Mice with conditional inactivation of fibroblast growth factor receptor-2 signaling in oligodendrocytes have normal myelin but display dramatic hyperactivity when combined with Cnp1 inactivation
    Y Kaga
    Department of Neuroscience, University of Connecticut Medical School, Farmington, Connecticut 06030, USA
    J Neurosci 26:12339-50. 2006
    ..b>Fgfr2 is expressed by OLs in myelinated fiber tracks...
  62. ncbi Distinct roles of fibroblast growth factor receptor 1 and 2 in regulating cell survival and epithelial-mesenchymal transition
    Wa Xian
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 21:987-1000. 2007
    Two related receptor tyrosine kinases (RTKs), fibroblast growth factor receptor 1 and 2 (FGFR1 and FGFR2), exert distinct effects during carcinogenesis...
  63. ncbi RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis
    Vivek Shukla
    Genetics of Development and Disease Branch, National Institute of Diabetes, Digestive and Kidney Diseases, US National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, USA
    Nat Genet 39:1145-50. 2007
    ..primarily caused by missense mutations leading to amino acid changes S252W or P253R in fibroblast growth factor receptor 2 (FGFR2)...
  64. doi Sox9 is required for prostate development
    Martin K Thomsen
    Section of Gene Function and Regulation, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
    Dev Biol 316:302-11. 2008
    ..shown to be important in prostate development and a lobe specific phenotype was reported for a prostate specific Fgfr2 mutant mouse model...
  65. pmc The study of abnormal bone development in the Apert syndrome Fgfr2+/S252W mouse using a 3D hydrogel culture model
    Fan Yang
    Department of Chemical Engineering, Massachusetts Institute of Technology, 45 Carleton Street, E25 342, Cambridge, MA 02142, USA
    Bone 43:55-63. 2008
    Apert syndrome is caused by mutations in fibroblast growth factor receptor 2 (Fgfr2) and is characterized by craniosynostosis and other skeletal abnormalities. The Apert syndrome Fgfr2+/S252W mouse model exhibits perinatal lethality...
  66. doi Carcinoma-associated fibroblasts activate progesterone receptors and induce hormone independent mammary tumor growth: A role for the FGF-2/FGFR-2 axis
    Sebastián Giulianelli
    Laboratory of Hormonal Carcinogenesis, Institute of Experimental Biology and Medicine IBYME National Research Council of Argentina CONICET, Buenos Aires, Argentina
    Int J Cancer 123:2518-31. 2008
    ..In summary, this is the first study reporting differences between CAF from HD and HI tumors suggesting that CAF-HI actively participate in driving HI tumor growth...
  67. pmc Nuclear factor Y is required for basal activation and chromatin accessibility of fibroblast growth factor receptor 2 promoter in osteoblast-like cells
    Fenyong Sun
    Institute of Genetic Engineering, Jinan University, National Engineering Research Center of Genetic Medicine, Key Lab for Genetic Medicine of Guangdong Province, Guangzhou, China
    J Biol Chem 284:3136-47. 2009
    b>Fibroblast growth factor receptor 2 (FGFR2) plays an important regulatory role in bone development. However, the regulatory mechanisms controlling FGFR2 expression remain poorly understood...
  68. pmc The p107/E2F pathway regulates fibroblast growth factor 2 responsiveness in neural precursor cells
    Kelly A McClellan
    University of Ottawa, Department of Cellular and Molecular Medicine, Ontario, Canada
    Mol Cell Biol 29:4701-13. 2009
    ..By identifying novel roles for p107/E2F in regulating genes outside of the classical cell cycle machinery targets, we uncover a new mechanism whereby Rb/E2F mediates proliferation through regulating growth factor responsiveness...
  69. ncbi Promoter region of the murine fibroblast growth factor receptor 2 (bek/KGFR) gene
    A Avivi
    Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel
    Oncogene 7:1957-62. 1992
    ..Both FGFR2 and keratinocyte growth factor receptor (KGFR) are encoded by the same gene, bek...
  70. ncbi Developmental expression of two murine fibroblast growth factor receptors, flg and bek
    A Orr-Urtreger
    Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel
    Development 113:1419-34. 1991
    Developmental expression of two closely related fibroblast growth factor receptors, bek and flg, is described from early postimplantation until advanced organogenesis...
  71. ncbi PCR-based identification of new receptors: molecular cloning of a receptor for fibroblast growth factors
    V Raz
    Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel
    Oncogene 6:753-60. 1991
    ..Molecular cloning of one of these genes, which is identical to the partially characterized bek gene, identified a transmembrane tyrosine kinase with three immunoglobulin-like domains in the extracellular ..
  72. ncbi Pattern of keratinocyte growth factor and keratinocyte growth factor receptor expression during mouse fetal development suggests a role in mediating morphogenetic mesenchymal-epithelial interactions
    P W Finch
    Department of Clinical Neurosciences, Brown University, Rhode Island Hospital, Providence 02903, USA
    Dev Dyn 203:223-40. 1995
    ..this hypothesis, in situ hybridization was used to examine the spatial distribution of KGF and KGF receptor (KGFR) transcripts during organogenesis and limb formation in mouse embryos (days 14.5 through 16.5)...
  73. ncbi The function of KGF in morphogenesis of epithelium and reepithelialization of wounds
    S Werner
    Cardiovascular Research Institute, University of California at San Francisco UCSF 94143 0130
    Science 266:819-22. 1994
    ..Upon skin injury, inhibition of KGF receptor signaling reduced the proliferation rate of epidermal keratinocytes at the wound edge, resulting in substantially delayed reepithelialization of the wound...
  74. ncbi Activation of FGF receptors by mutations in the transmembrane domain
    Y Li
    Department of Microbiology and Kaplan Cancer Center, New York University School of Medicine, New York, NY 10016, USA
    Oncogene 14:1397-406. 1997
    ..These findings also support the newly identified role of FGF signaling as a negative regulator of bone growth...
  75. ncbi Expression of fibroblast growth factor receptors (FGFR1, FGFR2, FGFR3) in the developing head and face
    T A Wilke
    Department of Oral Health Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada
    Dev Dyn 210:41-52. 1997
    ..Receptor transcripts, especially those of FGFR2 and FGFR3, were localized to specific regions of the head...
  76. ncbi Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction
    X Xu
    Laboratory of Biochemistry and Metabolism, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Development 125:753-65. 1998
    b>FGFR2 is a membrane-spanning tyrosine kinase that serves as a high affinity receptor for several members of the fibroblast growth factor (FGF) family...
  77. pmc Soluble dominant-negative receptor uncovers essential roles for fibroblast growth factors in multi-organ induction and patterning
    G Celli
    Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    EMBO J 17:1642-55. 1998
    ....
  78. pmc Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development
    E Arman
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel 76100, USA
    Proc Natl Acad Sci U S A 95:5082-7. 1998
    We disrupted the fibroblast growth factor (FGF) receptor 2 (FGFR2) gene by introducing a neo cassette into the IIIc ligand binding exon and by deleting a genomic DNA fragment encoding its transmembrane domain and part of its kinase I ..
  79. pmc Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless
    H Min
    Department of Molecular Genetics, Amgen, Inc, Thousand Oaks, California 91320 1789 USA
    Genes Dev 12:3156-61. 1998
    ..The pulmonary phenotype of Fgf-10(-/-) mice is strikingly similar to that of the Drosophila mutant branchless, an Fgf homolog...
  80. ncbi Fibroblast growth factor receptors (FGFRs) and their roles in limb development
    X Xu
    Genetics of Development and Disease Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, 10 9N105, 10 Center Drive, Bethesda, MD 20892, USA
    Cell Tissue Res 296:33-43. 1999
    ..In this review we discuss recent work with FGF receptors to illustrate mechanisms, through which the FGF/FGFR signals specify vertebrate limb initiation, outgrowth and patterning...
  81. pmc Fgfr2 is required for limb outgrowth and lung-branching morphogenesis
    E Arman
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 96:11895-9. 1999
    The aim of this study was to clarify the role of Fgfr2 during later stages of embryonic development...
  82. ncbi Expression patterns of Twist and Fgfr1, -2 and -3 in the developing mouse coronal suture suggest a key role for twist in suture initiation and biogenesis
    D Johnson
    Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK
    Mech Dev 91:341-5. 2000
    ..Twist expression domains show some overlap with those of Fgfr2, which is expressed in the most immature (proliferating) osteogenic tissue.
  83. ncbi Molecular analysis of external genitalia formation: the role of fibroblast growth factor (Fgf) genes during genital tubercle formation
    R Haraguchi
    Center for Animal Resources and Development CARD, Kumamoto University, Honjo 2 2 1, Kumamoto 860 0811, Japan
    Development 127:2471-9. 2000
    ..These results suggest that the FGF system is a key element in orchestrating GT development...
  84. ncbi FGF/FGFR-2(IIIb) signaling is essential for inner ear morphogenesis
    U Pirvola
    Institute of Biotechnology and Department of Otorhinolaryngology, University of Helsinki, 00014 Helsinki, Finland
    J Neurosci 20:6125-34. 2000
    ..Our findings provide genetic evidence that signaling by FGFR-2(IIIb) is critical for the morphological development of the inner ear...
  85. ncbi The mouse Fgfrl1 gene coding for a novel FGF receptor-like protein
    M Wiedemann
    M E Müller Institute, University of Bern, P O Box 30, CH 3010, Bern, Switzerland
    Biochim Biophys Acta 1520:247-50. 2001
    ..The gene for Fgfrl1 comprises six exons and is located on mouse chromosome 5 in close proximity to the Idua gene for L-iduronidase...
  86. ncbi Embryonic submandibular gland morphogenesis: stage-specific protein localization of FGFs, BMPs, Pax6 and Pax9 in normal mice and abnormal SMG phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) mice
    Tina Jaskoll
    Laboratory for Developmental Genetics, University of Southern California, Los Angeles, CA 90089 0641, USA
    Cells Tissues Organs 170:83-98. 2002
    ..In addition, we report abnormal SMG phenotypes in FgfR2- IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) mice...
  87. ncbi Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo
    Arnaud André Mailleux
    UMR144 CNRS Institut Curie, 26 rue d Ulm 75248 Paris Cedex 05, France
    Development 129:53-60. 2002
    ..Our results also suggest that FGF signaling is involved in the maintenance of mammary bud 4, and that Fgf10 deficient epithelium can undergo branching morphogenesis into the mammary fat pad precursor...
  88. pmc Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung
    Pao Tien Chuang
    Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
    Genes Dev 17:342-7. 2003
    ..Our studies focused on Hip1 in the lung. Here, a dynamic interaction between Hh and fibroblast growth factor (Fgf) signaling, modulated at least in part by Hip1, controls early lung branching...
  89. ncbi Fibroblast growth factor receptor signalling is crucial for liver homeostasis and regeneration
    Heike Steiling
    Institute of Cell Biology, ETH Zurich, Honggerberg, CH 8093 Zurich, Switzerland
    Oncogene 22:4380-8. 2003
    ..These data demonstrate a key role of FGFR signalling in repair after liver injury...
  90. ncbi A Ser252Trp [corrected] substitution in mouse fibroblast growth factor receptor 2 (Fgfr2) results in craniosynostosis
    Lin Chen
    Genetics of Development and Disease Branch, NIDDK NIH, 10 9N105, 10 Center Drive, Bethesda, MD 20892, USA
    Bone 33:169-78. 2003
    ..Mutations of either Ser252Trp or Pro253Arg in fibroblast growth factor receptor 2 (FGFR2) are responsible for nearly all known cases of AS...
  91. ncbi A crucial role for Fgfr2-IIIb signalling in epidermal development and hair follicle patterning
    Anita Petiot
    Cancer Research UK, London Research Institute, 61 Lincoln s Inn Fields, London WC2A 3PX, UK
    Development 130:5493-501. 2003
    ..the role Fgf signalling in skin and hair follicle development, we analysed the phenotype of mice deficient for Fgfr2-IIIb and its main ligand Fgf10...
  92. ncbi Requirement for fibroblast growth factor 10 or fibroblast growth factor receptor 2-IIIb signaling for cecal development in mouse
    R C Burns
    Division of Developmental Biology, Department of Surgery, USC Keck School of Medicine and the Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    Dev Biol 265:61-74. 2004
    ..Thus, FGF10 signaling via FGFR2b appears to be critical in the extension of the epithelium into the mesenchyme during cecal development...
  93. pmc A gain-of-function mutation of Fgfr2c demonstrates the roles of this receptor variant in osteogenesis
    Veraragavan P Eswarakumar
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 101:12555-60. 2004
    The b and c variants of fibroblast growth factor receptor 2 (FGFR2) differ in sequence, binding specificity, and localization...
  94. ncbi Endocardial and epicardial derived FGF signals regulate myocardial proliferation and differentiation in vivo
    Kory J Lavine
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, MO 63110, USA
    Dev Cell 8:85-95. 2005
    ..FGFs thus constitute all or part of the epicardial signal regulating myocardial growth and differentiation...
  95. ncbi Signaling through FGF receptor-2 is required for lens cell survival and for withdrawal from the cell cycle during lens fiber cell differentiation
    Claudia M Garcia
    Department of Ophthalmology and Visual Sciences, Washington University, St Louis, Missouri 63110, USA
    Dev Dyn 233:516-27. 2005
    ..To address the role of FGFs in lens development, we inactivated FGF receptor-2 (Fgfr2) using a Cre transgene that is expressed in all prospective lens cells from embryonic day 9.0...
  96. ncbi Expression of Fgf receptors 1, 2, and 3 in the developing mid- and hindbrain of the mouse
    Alexandra A Blak
    GSF National Research Center for Environment and Health, Institute of Developmental Genetics, Neuherberg, Germany
    Dev Dyn 233:1023-30. 2005
    ..in early vertebrate development have shown that Fgfr1 is expressed along the entire neural tube, whereas Fgfr2 and Fgfr3 expression has been shown to spare the tissue adjacent to the MHO...
  97. ncbi Abnormalities in cartilage and bone development in the Apert syndrome FGFR2(+/S252W) mouse
    Yingli Wang
    Institute of Genetic Medicine, Department of Pediatrics, The Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA
    Development 132:3537-48. 2005
    ..Two-thirds of affected individuals have a S252W mutation in fibroblast growth factor receptor 2 (FGFR2)...
  98. pmc Conditional knockdown of Fgfr2 in mice using Cre-LoxP induced RNA interference
    Xavier Coumoul
    Genetics of Development and Disease Branch, 10 9N105, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health Bethesda, Maryland, MD 20892, USA
    Nucleic Acids Res 33:e102. 2005
    ..we validate this system in mouse and show that it can be used to suppress the expression of an endogenous gene (Fgfr2) with high efficiency...
  99. ncbi FGF9 and SHH signaling coordinate lung growth and development through regulation of distinct mesenchymal domains
    Andrew C White
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, MO 63110, USA
    Development 133:1507-17. 2006
    ..from the mesothelium (the future pleura) to sub-mesothelial mesenchyme through both FGF receptor (FGFR) 1 and FGFR2 to induce proliferation...
  100. ncbi Stomach development is dependent on fibroblast growth factor 10/fibroblast growth factor receptor 2b-mediated signaling
    Bradley Spencer-Dene
    Experimental Pathology Laboratory, Cancer Research UK, London Research Institute, London, England
    Gastroenterology 130:1233-44. 2006
    ..surrounding mesenchyme are largely unknown; however, the developmental expression profile of the IIIb isoform of Fgfr2 (Fgfr2b) and its main ligand, Fgf10, suggest that they may be strong candidates...
  101. ncbi FGF as a target-derived chemoattractant for developing motor axons genetically programmed by the LIM code
    Ryuichi Shirasaki
    Gene Expression Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Neuron 50:841-53. 2006
    ..These results point to a role for FGF signaling in axon guidance and further unravel how downstream effectors of LIM codes direct wiring of the developing nervous system...

Research Grants7

  1. ETHANOL, RETINOIDS, AND CONGENITAL HEART MALFORMATIONS
    Janee Gelineau van Waes; Fiscal Year: 2003
    ..abstract_text> ..
  2. Somatic support cell function in gonad development
    GERRIT BOUMA; Fiscal Year: 2006
    ..The proposed experiments will identify genes expressed in gonadal SSCs that play a role in gonadal XY sex reversal. ..
  3. Regulation of parietal bone differentiation
    Venkatesh Govindarajan; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  4. Eda/Edar Regulation of Embryonic SMG Development
    Tina Jaskoll; Fiscal Year: 2007
    ....
  5. PROTEOMIC MAPPING OF MYELIN AND ITS MEMBRANE SUBDOMAINS
    Rashmi Bansal; Fiscal Year: 2009
    ....
  6. Mechanisms of endoderm specification along the A-P axis.
    James M Wells; Fiscal Year: 2010
    ..Additionally, this information should allow us to coax embryonic stem cells into becoming important transplantable derivatives of endoderm, such as insulin-producing beta cells to treat patients with Type 1 diabetes. ..
  7. Molecular Regulation of Ocular Gland Development
    Venkatesh Govindarajan; Fiscal Year: 2010
    ..In addition, the proposed studies will, in the long-term, allow the development of novel therapeutic approaches for treatment of patients with dry eye syndromes. ..