Fn1

Summary

Gene Symbol: Fn1
Description: fibronectin 1
Alias: E330027I09, Fn-1, fibronectin
Species: mouse

Top Publications

  1. ncbi Mesodermal development in mouse embryos mutant for fibronectin
    E N Georges-Labouesse
    Howard Hughes Medical Institute, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139, USA
    Dev Dyn 207:145-56. 1996
  2. ncbi Hyperglycemia-induced TGFbeta and fibronectin expression in embryonic mouse heart
    Ida Washington Smoak
    Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, North Carolina
    Dev Dyn 231:179-89. 2004
  3. doi Isolation and characterization of a large soluble form of fibronectin that stimulates adhesion, spreading, and alignment of mouse erythroleukemia cells
    Barbara M Scher
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Exp Cell Res 316:2402-13. 2010
  4. pmc Biologically active fibronectin fragments stimulate release of MCP-1 and catabolic cytokines from murine retinal pigment epithelium
    Bobbie Ann Austin
    National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
    Invest Ophthalmol Vis Sci 50:2896-902. 2009
  5. ncbi Identification and mapping of six microdissected genomic DNA probes to the proximal region of mouse chromosome 1
    S M Vidal
    Department of Biochemistry, McGill University, Montreal, Canada
    Genomics 14:32-7. 1992
  6. ncbi Mapping of mouse gamma crystallin genes on chromosome 1
    L C Skow
    Department of Veterinary Anatomy, College of Veterinary Medicine, Texas A and M University, College Station 77843 4458
    Biochem Genet 26:557-70. 1988
  7. ncbi Regional localization of the fibronectin and gamma crystallin genes to mouse chromosome 1 by in situ hybridization
    S M Zneimer
    Department of Veterinary Pathology, College of Veterinary Medicine, Texas A and M University, College Station 77843
    Cytogenet Cell Genet 48:238-41. 1988
  8. ncbi Changing patterns of cell adhesion molecules during mouse pelage hair follicle development. 1. Follicle morphogenesis in wild-type mice
    M H Hardy
    Department of Biomedical Sciences, University of Guelph, Ont, Canada
    Acta Anat (Basel) 157:169-82. 1996
  9. ncbi Ultrastructural localization of microfibrillar fibulin-1 and fibulin-2 during heart development indicates a switch in molecular associations
    N Miosge
    Abteilung Histologie, Universitat Gottingen, Germany
    Cell Mol Life Sci 54:606-13. 1998
  10. pmc Perinatal lethality and endothelial cell abnormalities in several vessel compartments of fibulin-1-deficient mice
    G Kostka
    Max Planck Institut fur Biochemie, D 82152 Martinsried, Germany
    Mol Cell Biol 21:7025-34. 2001

Research Grants

  1. ROLE OF FIBRONECTIN IN AIRWAY REMODELING IN ASTHMA
    DENISE HOCKING; Fiscal Year: 2002
  2. FIBRONECTIN DEPOSITION AND PULMONARY FIBROSIS
    DENISE HOCKING; Fiscal Year: 2002
  3. Extracellular Matrix Remodeling and Tissue Mechanics
    DENISE HOCKING; Fiscal Year: 2004
  4. Mechanisms of Tissue Remodeling By Ultrasound
    DENISE HOCKING; Fiscal Year: 2004
  5. Ultrasound Technologies for Tissue Engineering
    DENISE C contact HOCKING; Fiscal Year: 2010
  6. FN FAK SIGNALING AXIS AND TUMORIGENESIS
    Dusko Ilic; Fiscal Year: 2004
  7. Cardiac Teratogenicity of Lithium
    Kersti Linask; Fiscal Year: 2004
  8. THE ROLE OF SRF IN CARDIAC FUNCTION AND DEVELOPMENT
    RAVINDRA MISRA; Fiscal Year: 2005
  9. Transcriptional Control of Early Coronary Vascular Development
    RAVINDRA P MISRA; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications132 found, 100 shown here

  1. ncbi Mesodermal development in mouse embryos mutant for fibronectin
    E N Georges-Labouesse
    Howard Hughes Medical Institute, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139, USA
    Dev Dyn 207:145-56. 1996
    Three independent mutations were made by homologous recombination in two different regions of the fibronectin (FN) gene; all three appeared to be functional null mutations...
  2. ncbi Hyperglycemia-induced TGFbeta and fibronectin expression in embryonic mouse heart
    Ida Washington Smoak
    Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, North Carolina
    Dev Dyn 231:179-89. 2004
    ..was to characterize TGF beta expression in the organogenesis-stage mouse heart and to evaluate TGF beta and fibronectin expression in embryonic mouse heart exposed to hyperglycemia...
  3. doi Isolation and characterization of a large soluble form of fibronectin that stimulates adhesion, spreading, and alignment of mouse erythroleukemia cells
    Barbara M Scher
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Exp Cell Res 316:2402-13. 2010
    b>Fibronectin (FN) is a major component of the extracellular matrix which plays important roles in a variety of cellular processes including cell adhesion, and migration...
  4. pmc Biologically active fibronectin fragments stimulate release of MCP-1 and catabolic cytokines from murine retinal pigment epithelium
    Bobbie Ann Austin
    National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
    Invest Ophthalmol Vis Sci 50:2896-902. 2009
    ..In the present study, the authors focused on a substrate of HTRA1, fibronectin, because fibronectin fragments (Fnfs) stimulate biochemical events in other age-related degenerative diseases ..
  5. ncbi Identification and mapping of six microdissected genomic DNA probes to the proximal region of mouse chromosome 1
    S M Vidal
    Department of Biochemistry, McGill University, Montreal, Canada
    Genomics 14:32-7. 1992
    ..These novel polymorphic probes should prove useful for linkage and physical mapping of this chromosomal region...
  6. ncbi Mapping of mouse gamma crystallin genes on chromosome 1
    L C Skow
    Department of Veterinary Anatomy, College of Veterinary Medicine, Texas A and M University, College Station 77843 4458
    Biochem Genet 26:557-70. 1988
    ..isocitrate dehydrogenase (Idh-1), a low molecular weight (LM) crystallin protein polymorphism (Len-1), and fibronectin (Fn-1)...
  7. ncbi Regional localization of the fibronectin and gamma crystallin genes to mouse chromosome 1 by in situ hybridization
    S M Zneimer
    Department of Veterinary Pathology, College of Veterinary Medicine, Texas A and M University, College Station 77843
    Cytogenet Cell Genet 48:238-41. 1988
    Genes for fibronectin, gamma crystallin, and isocitrate dehydrogenase-1 are syntenic in mouse, man, and cow...
  8. ncbi Changing patterns of cell adhesion molecules during mouse pelage hair follicle development. 1. Follicle morphogenesis in wild-type mice
    M H Hardy
    Department of Biomedical Sciences, University of Guelph, Ont, Canada
    Acta Anat (Basel) 157:169-82. 1996
    ..The results suggest that the main role of cell adhesion molecules is to mould the follicle by relaxing or reinforcing cell contacts in areas of increased morphogenetic activity...
  9. ncbi Ultrastructural localization of microfibrillar fibulin-1 and fibulin-2 during heart development indicates a switch in molecular associations
    N Miosge
    Abteilung Histologie, Universitat Gottingen, Germany
    Cell Mol Life Sci 54:606-13. 1998
    ..has now been used to compare their localization in embryonic (days 9-11) and adult mouse heart with that of fibronectin and the chondroitin sulphate proteoglycan versican...
  10. pmc Perinatal lethality and endothelial cell abnormalities in several vessel compartments of fibulin-1-deficient mice
    G Kostka
    Max Planck Institut fur Biochemie, D 82152 Martinsried, Germany
    Mol Cell Biol 21:7025-34. 2001
    ..The data indicate a strong but restricted abnormality in some endothelial compartments which, together with some kidney and lung defects, may be responsible for early death...
  11. ncbi Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1
    Nathan V Lee
    Department of Molecular, Cell, and Developmental Biology and Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Biol Chem 280:34796-804. 2005
    ..Together, these findings indicate that fibulin-1 is a new regulator of ADAMTS-1-mediated proteoglycan proteolysis and thus may play an important role in proteoglycan turnover in tissues where there is overlapping expression...
  12. pmc Increased expression of fibronectin and the alpha 5 beta 1 integrin in angiogenic cerebral blood vessels of mice subject to hypobaric hypoxia
    Richard Milner
    Department of Molecular and Experimental Medicine, MEM 132, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Cell Neurosci 38:43-52. 2008
    ..We showed previously that angiogenic capillaries in the developing CNS express high levels of fibronectin and its receptor alpha5beta1 integrin, and that this expression is developmentally downregulated...
  13. pmc Fibulin-1 is required for morphogenesis of neural crest-derived structures
    Marion A Cooley
    Department of Cell Biology and Anatomy, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Dev Biol 319:336-45. 2008
    ....
  14. pmc Pref-1 interacts with fibronectin to inhibit adipocyte differentiation
    Yuhui Wang
    Department of Nutritional Science and Toxicology, University of California, Berkeley, CA 94720, USA
    Mol Cell Biol 30:3480-92. 2010
    ..Instead, we show a direct interaction of Pref-1 and fibronectin via the Pref-1 juxtamembrane domain and fibronectin C-terminal domain...
  15. ncbi Localization of types I and III collagen and fibronectin in the developing mouse palatal shelves
    Y Ohsaki
    Second Department of Oral Anatomy, Kyushu University, Fukuoka, Japan
    Acta Anat (Basel) 153:161-7. 1995
    The detailed distribution of types I and III collagen and fibronectin was studied in the developing mouse palatal shelf using a double immunofluorescence technique...
  16. ncbi Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins
    B L Bader
    Howard Hughes Medical Institute, Center for Cancer Research, Cambridge, Massachusetts 02139, USA
    Cell 95:507-19. 1998
    ..These results necessitate reevaluation of the primacy of alphav integrins in many functions including vascular development, despite reports that blockade of these integrins with antibodies or peptides prevents angiogenesis...
  17. ncbi Overlapping and independent functions of fibronectin receptor integrins in early mesodermal development
    J T Yang
    Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Dev Biol 215:264-77. 1999
    Mouse embryos deficient in fibronectin (FN-null) die at E8.5 with mesodermal defects. Eight integrin heterodimers alpha3beta1, alpha4beta1, alpha5beta1, alpha8beta1, alphavbeta1, alphavbeta3, alphavbeta6, and alphaIIbbeta3 can bind to FN...
  18. pmc A cryptic fragment from fibronectin's III1 module localizes to lipid rafts and stimulates cell growth and contractility
    Denise C Hocking
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Cell Biol 158:175-84. 2002
    The interaction of cells with the extracellular matrix (ECM) form of fibronectin (FN) triggers changes in growth, migration, and cytoskeletal organization that differ from those generated by soluble FN...
  19. doi Fibrillin-1 microfibril deposition is dependent on fibronectin assembly
    Rachel Kinsey
    Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Science, Michael Smith Building, Oxford Road, University of Manchester, Manchester M139PT, UK
    J Cell Sci 121:2696-704. 2008
    Newly deposited microfibrils strongly colocalise with fibronectin in primary fibroblasts. Microfibril formation is grossly inhibited by fibronectin depletion, but rescued by supplementation with exogenous cellular fibronectin...
  20. pmc Endothelial alpha5 and alphav integrins cooperate in remodeling of the vasculature during development
    Arjan van der Flier
    Howard Hughes Medical Institute, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Development 137:2439-49. 2010
    Integrin cell adhesion receptors and fibronectin, one of their extracellular matrix ligands, have been demonstrated to be important for angiogenesis using functional perturbation studies and complete knockout mouse models...
  21. pmc Essential roles of fibronectin in the development of the left-right embryonic body plan
    Maria V Pulina
    Weill Cornell Medical College, Department of Medicine, Division of Cardiology, New York, NY, USA
    Dev Biol 354:208-20. 2011
    ..Taken together, our studies demonstrate the requisite role for a structural ECM protein and its integrin receptor in the development of the left-right axis of asymmetry in vertebrates...
  22. ncbi Mice develop normally without tenascin
    Y Saga
    Laboratory of Cell Biology, Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
    Genes Dev 6:1821-31. 1992
    ..histological abnormalities were detected in any tissues, and no major changes were observed in distribution of fibronectin, laminin, collagen, and proteoglycan...
  23. pmc Tenascin during gut development: appearance in the mesenchyme, shift in molecular forms, and dependence on epithelial-mesenchymal interactions
    E Aufderheide
    Friederich Miescher Laboratorium der Max Planck Gesellschaft, Tubingen, Federal Republic of Germany
    J Cell Biol 107:2341-9. 1988
    ..We propose that growing and differentiating epithelia produce locally active factors which stimulate synthesis of tenascin in the surrounding mesenchyme...
  24. ncbi Alternative splicing of fibronectin--many different proteins but few different functions
    C ffrench-Constant
    Wellcome CRC Institute of Developmental Biology and Cancer, Cambridge, United Kingdom
    Exp Cell Res 221:261-71. 1995
  25. ncbi Embryonic mesodermal defects in alpha 5 integrin-deficient mice
    J T Yang
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139
    Development 119:1093-105. 1993
    ..However, the embryos progress significantly further than embryos null for fibronectin, for which alpha 5 beta 1 integrin is a receptor, suggesting the involvement of other fibronectin receptors...
  26. ncbi Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin
    E L George
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139
    Development 119:1079-91. 1993
    To examine the role of fibronectin in vivo, we have generated mice in which the fibronectin gene is inactivated. Heterozygotes have one half normal levels of plasma fibronectin, yet appear normal...
  27. ncbi Fibronectin isoform distribution in the mouse. I. The alternatively spliced EIIIB, EIIIA, and V segments show widespread codistribution in the developing mouse embryo
    J H Peters
    Division of Pulmonary Medicine, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Cell Adhes Commun 4:103-25. 1996
    ..Conversely, these segments would appear to play divergent, and sometimes exclusive, biological roles in specific tissues such as liver, cartilage, and placenta...
  28. ncbi Fibronectins are essential for heart and blood vessel morphogenesis but are dispensable for initial specification of precursor cells
    E L George
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Blood 90:3073-81. 1997
    The underlying mechanisms of lethal cardiovascular defects associated with the fibronectin-null (FN.null) mutation in mouse embryos were investigated by lineage analysis of myocardial, endocardial, and endothelial cells...
  29. ncbi Cleft palate formation in fetal Br mice with midfacial retrusion: tenascin, fibronectin, laminin, and type IV collagen immunolocalization
    G D Singh
    Department of Dental Surgery and Periodontology, Dundee Dental Hospital and School, University of Dundee, Scotland, UK
    Cleft Palate Craniofac J 35:65-76. 1998
    ..altered craniofacial morphology does not affect the expression of extracellular matrix (ECM) molecules such as fibronectin (FN), laminin (LN), type IV collagen, and tenascin-C (TN) but is associated with failure of palatal shelf ..
  30. ncbi A test of the role of alpha5 integrin/fibronectin interactions in tumorigenesis
    D Taverna
    Howard Hughes Medical Institute and Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cancer Res 58:848-53. 1998
    Published data show that reduction or loss of fibronectin or its receptor, alpha5beta1 integrin, occurs frequently in tumors and transformed cells...
  31. ncbi Regulation of the fibronectin EDA exon alternative splicing. Cooperative role of the exonic enhancer element and the 5' splicing site
    A F Muro
    International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
    FEBS Lett 437:137-41. 1998
    ..The EDA exon of the fibronectin gene is a typical example of an exon bearing a purine-rich exon splicing enhancer (ESE) element recognised by ..
  32. ncbi Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development
    H M Arthur
    SMIVS, School of Biochemistry and Genetics, United Kingdom
    Dev Biol 217:42-53. 2000
    ..We anticipate that heterozygous mice will ultimately serve as a useful disease model for HHT1, as some individuals have dilated and fragile blood vessels similar to vascular malformations seen in HHT patients...
  33. ncbi Disruption of the talin gene arrests mouse development at the gastrulation stage
    S J Monkley
    Department of Biochemistry, University of Leicester, University Road, Leicester, United Kingdom
    Dev Dyn 219:560-74. 2000
    ..Spreading of trophoblast cells derived from cultured mutant blastocysts on fibronectin and laminin is also considerably reduced...
  34. ncbi Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis
    T Sakai
    Department of Experimental Pathology, Lund University, Lund, Sweden
    Nat Med 7:324-30. 2001
    b>Fibronectin performs essential roles in embryonic development and is prominently expressed during tissue repair...
  35. ncbi The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis
    J Oh
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, 606 8501, Kyoto, Japan
    Cell 107:789-800. 2001
    ..These results support a role for RECK in the regulation of MMP-2 in vivo and implicate RECK downregulation in tumor angiogenesis...
  36. pmc Dual functions of [alpha]4[beta]1 integrin in epicardial development: initial migration and long-term attachment
    Jennifer K Sengbusch
    Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Cell Biol 157:873-82. 2002
    ..T., H. Rayburn, and R.O. Hynes. 1995. Development. 121:549-560)...
  37. ncbi Mice lacking the EDB segment of fibronectin develop normally but exhibit reduced cell growth and fibronectin matrix assembly in vitro
    Tomohiko Fukuda
    Institute for Protein Research, Osaka University, Suita, Osaka 565 0871, Japan
    Cancer Res 62:5603-10. 2002
    ..These results indicate that expression of EDB-containing isoforms is dispensable during embryonic development, yet may play a modulating role in the growth of connective tissue cells via the FN matrix...
  38. pmc Plasma fibronectin promotes thrombus growth and stability in injured arterioles
    Heyu Ni
    Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:2415-9. 2003
    ..The platelets of these animals accumulate excessive amounts of fibronectin (FN). These observations led us to examine the contribution of plasma FN (pFN) to thrombus formation...
  39. ncbi Fibronectin matrix polymerization regulates small airway epithelial cell migration
    Denise C Hocking
    Department of Pharmacologyand physiology, University of Rochester Medical Center, 601 Elmwood Ave, Box 711, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 285:L169-79. 2003
    The continuous conversion of soluble fibronectin into extracellular matrix fibrils occurs through a dynamic, cell-dependent process...
  40. pmc Increased fibronectin deposition in embryonic hearts of retinol-binding protein-null mice
    Christopher C Wendler
    Department of Cell Biology, Neurobiology and Anatomy and the Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Circ Res 92:920-8. 2003
    ..Most remarkably, RBP-null hearts display augmented deposition of fibronectin protein in the cardiac jelly at E9.0 through E10.5 and in the outflow tract at E12.5...
  41. ncbi Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin
    Guoying Jiang
    Department of Biological Sciences, Columbia University, 1212 Amsterdam Avenue, New York, New York 11027, USA
    Nature 424:334-7. 2003
    ..The minimal matrix complex causing integrin-cytoskeleton connections is a trimer of fibronectin's integrin-binding domain FNIII7-10 (ref. 4)...
  42. ncbi Deletion of the alternatively spliced fibronectin EIIIA domain in mice reduces atherosclerosis
    Michelle H Tan
    Vascular Research Division, Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
    Blood 104:11-8. 2004
    The alternatively spliced and highly conserved EIIIA domain of fibronectin (FN) is included in most FN of the extracellular matrix in embryos. In adults, both extracellular matrix and plasma FN essentially lack EIIIA...
  43. pmc Direct test of potential roles of EIIIA and EIIIB alternatively spliced segments of fibronectin in physiological and tumor angiogenesis
    Sophie Astrof
    Howard Hughes Medical Institute, Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Mol Cell Biol 24:8662-70. 2004
    b>Fibronectin splice variants containing the EIIIA and/or EIIIB exons are prominently expressed in the vasculature of a variety of human tumors but not in normal adult tissues...
  44. ncbi Transforming growth factor beta-SMAD2 signaling regulates aortic arch innervation and development
    Daniel G M Molin
    Department of Anatomy and Embryology, Leiden University Medical Center, PO Box 9602, 2300 RC Leiden, The Netherlands
    Circ Res 95:1109-17. 2004
    ..For diminished transforming growth factor beta (TGF-beta) signaling, SMAD2 and fibronectin have been analyzed...
  45. ncbi Fibronectin regulates latent transforming growth factor-beta (TGF beta) by controlling matrix assembly of latent TGF beta-binding protein-1
    Sarah L Dallas
    Department of Oral Biology, School of Dentistry, University of Missouri, Kansas City, Missouri 64108, USA
    J Biol Chem 280:18871-80. 2005
    ..Here we show that fibronectin is critical for the incorporation of LTBP1 and transforming growth factor-beta (TGF beta) into the ECM of ..
  46. ncbi Fibronectin is required for integrin alphavbeta6-mediated activation of latent TGF-beta complexes containing LTBP-1
    Laura Fontana
    Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    FASEB J 19:1798-808. 2005
    ..The LTBP-1 polypeptide rL1N, which includes the hinge, associates with fibronectin in binding assays...
  47. pmc pVHL function is essential for endothelial extracellular matrix deposition
    Nan Tang
    Molecular Biology Section, MC 0377, Division of Biological Sciences, University of California San Diego, La Jolla, California 92093 0377, USA
    Mol Cell Biol 26:2519-30. 2006
    ..The defects in embryonic vascularization were correlated with a diminished vascular fibronectin deposition in vivo and defective endothelial extracellular fibronectin assembly in vitro...
  48. ncbi Spontaneous formation of L-isoaspartate and gain of function in fibronectin
    Flavio Curnis
    Department of Oncology, Cancer Immunotherapy and Gene Therapy Program and Italian Institute of Technology Network Research Unit of Molecular Neuroscience, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    J Biol Chem 281:36466-76. 2006
    ..In particular, we show that deamidation of Asn263 at the Asn-Gly-Arg (NGR) site in fibronectin N-terminal region generates an alpha(v)beta3-integrin binding site containing the L-isoDGR sequence, which is ..
  49. pmc The ECM protein nephronectin promotes kidney development via integrin alpha8beta1-mediated stimulation of Gdnf expression
    James M Linton
    Department of Physiology, 1550 Fourth Street, University of California, San Francisco, San Francisco, CA 94143, USA
    Development 134:2501-9. 2007
    ..Our results thus place nephronectin and alpha8beta1 integrin in a pathway that regulates Gdnf expression and is essential for kidney development...
  50. pmc The RGD motif in fibronectin is essential for development but dispensable for fibril assembly
    Seiichiro Takahashi
    Max Planck Institute of Biochemistry, Department of Molecular Medicine, 82152 Martinsried, Germany
    J Cell Biol 178:167-78. 2007
    b>Fibronectin (FN) is secreted as a disulfide-bonded FN dimer. Each subunit contains three types of repeating modules: FN-I, FN-II, and FN-III...
  51. ncbi A major fraction of fibronectin present in the extracellular matrix of tissues is plasma-derived
    Federico A Moretti
    International Centre for Genetic Engineering and Biotechnology, 34012 Trieste, Italy
    J Biol Chem 282:28057-62. 2007
    The origin of the fibronectin (FN) found in the extracellular matrix of tissues has not been defined experimentally...
  52. pmc Alteration of medial-edge epithelium cell adhesion in two Tgf-beta3 null mouse strains
    Elena Martínez-Sanz
    Departamento de Anatomía y Embriología Humana I, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain
    Differentiation 76:417-30. 2008
    ..We have performed immunohistochemistry with antibodies against collagens IV and IX, laminin, fibronectin, the alpha5- and beta1-integrins, and ICAM-1; in situ hybridization with a Nectin-1 riboprobe; and palatal ..
  53. pmc Fibronectin binds and enhances the activity of bone morphogenetic protein 1
    Guorui Huang
    Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 284:25879-88. 2009
    ..Such processing includes proteolytic activation of the zymogen for lysyl oxidase. Fibronectin (FN) is an abundant protein component of the ECM that is capable of regulating manifold cellular functions ..
  54. pmc Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality
    Xingqun Liang
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093 0613, USA
    Circulation 120:568-76. 2009
    ..A potential role for PINCH proteins in myocardium remains unknown...
  55. doi Circulating fibronectin affects bone matrix, whereas osteoblast fibronectin modulates osteoblast function
    Anke Bentmann
    Max Planck Institute for Biochemistry, 82152 Martinsried, Germany
    J Bone Miner Res 25:706-15. 2010
    The bone matrix is composed mostly of collagen, but the initial and continuous presence of fibronectin was found to be crucial for collagen matrix integrity in vitro...
  56. pmc Fibronectin and integrin alpha 5 play essential roles in the development of the cardiac neural crest
    Ashok Mittal
    Weill Cornell Medical College, Department of Medicine, Division of Cardiology, New York, NY, USA
    Mech Dev 127:472-84. 2010
    ..b>Fibronectin (FN) protein is present along neural crest migration paths and neural crest cells migrate when plated on FN in ..
  57. pmc A fibronectin-independent mechanism of collagen fibrillogenesis in adult liver remodeling
    Kei Moriya
    Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Gastroenterology 140:1653-63. 2011
    ..Although it has been proposed that collagen organization and assembly depend on the fibronectin matrix in culture, the contribution of fibronectin to these processes remains to be defined in vivo.
  58. doi Lack of fibronectin-EDA promotes survival and prevents adverse remodeling and heart function deterioration after myocardial infarction
    Fatih Arslan
    Laboratory of Experimental Cardiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Circ Res 108:582-92. 2011
    ..The extracellular matrix protein fibronectin-EDA (EIIIA; EDA) is upregulated after tissue injury and may act as a "danger signal" for leukocytes to cause ..
  59. pmc Fibronectin protects from excessive liver fibrosis by modulating the availability of and responsiveness of stellate cells to active TGF-β
    Nina Kawelke
    Translational Medicine, Max Planck Institute for Biochemistry, Martinsried, Germany
    PLoS ONE 6:e28181. 2011
    Fibrotic tissue in the liver is mainly composed of collagen. Fibronectin, which is also present in fibrotic matrices, is required for collagen matrix assembly in vitro...
  60. pmc An essential requirement for β1 integrin in the assembly of extracellular matrix proteins within the vascular wall
    Kirsten A Turlo
    Department of Molecular, Cellular, and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Dev Biol 365:23-35. 2012
    ..It further establishes a critical role of β1 integrin in the protection against aneurysms that is particularly confined to the ascending aorta and its branches...
  61. pmc Putative functions of extracellular matrix glycoproteins in secondary palate morphogenesis
    Rocca d'Amaro
    Department of Orthodontics and Dentofacial Orthopedics, School of Dental Medicine, University of Bern Bern, Switzerland
    Front Physiol 3:377. 2012
    ..These provide substrates for cell adhesion (e.g., fibronectin, tenascins), but also regulate growth factor availability (e.g., fibrillins)...
  62. pmc Circulating fibronectin controls tumor growth
    Anja von Au
    Max Planck Institute of Biochemistry, Martinsried, Germany
    Neoplasia 15:925-38. 2013
    b>Fibronectin is ubiquitously expressed in the extracellular matrix, and experimental evidence has shown that it modulates blood vessel formation...
  63. doi Binding of soluble fibronectin to integrin alpha5 beta1 - link to focal adhesion redistribution and contractile shape
    Stephan Huveneers
    Division of Toxicology, Leiden Amsterdam Center for Drug Research, Einsteinweg 55, Leiden University, Leiden CC, The Netherlands
    J Cell Sci 121:2452-62. 2008
    ..Extensive remodeling of adhesions in fibroblasts also takes part in fibronectin fibrillogenesis, a process that depends on Rho-mediated contractility and results in the formation of a ..
  64. ncbi Cell adhesion events mediated by alpha 4 integrins are essential in placental and cardiac development
    J T Yang
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139, USA
    Development 121:549-60. 1995
    ..cell surface receptors that mediate cell-extracellular matrix (ECM) and cell-cell adhesions by interacting with fibronectin (FN) and vascular cell adhesion molecule 1 (VCAM-1), respectively...
  65. ncbi Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt signaling in branching morphogenesis of the mouse embryonic lung
    Stijn P De Langhe
    Developmental Biology Program, Department of Surgery, USC Keck School of Medicine and the Saban Research Institute of Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
    Dev Biol 277:316-31. 2005
    ..These defects coincide with a pattern of decreased fibronectin (FN) deposition...
  66. ncbi Splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3
    D J Epstein
    Department of Biology, McGill University, Montreal, Canada
    Cell 67:767-74. 1991
    ..Our study provides evidence for a causal link between deletion of the paired homeodomain of Pax-3 and the Sp2H mutation, and infers that Pax-3 plays a key role in normal neural development...
  67. ncbi Distinct adhesive behaviors of neurons and neural precursor cells during regional differentiation in the mammalian forebrain
    J G Whitesides
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Dev Biol 169:229-41. 1995
    ..These differences are transient and can only be detected in the telencephalic vesicle before and during the morphogenesis of rudiments of major forebrain subdivisions...
  68. ncbi Chromosomal location of the murine anion exchanger genes encoding AE2 and AE3
    R A White
    Section of Genetics, Children s Mercy Hospital, Kansas City, Missouri
    Mamm Genome 5:827-9. 1994
  69. ncbi The developing mouse thyroid: embryonic vessel contacts and parenchymal growth pattern during specification, budding, migration, and lobulation
    Henrik Fagman
    Institute of Anatomy and Cell Biology, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Dev Dyn 235:444-55. 2006
    ..It is suggested that thyroid inductive signals arise from embryonic vessels, and that this provides ideas to conceptually new pathogenetic mechanisms of thyroid dysgenesis...
  70. ncbi Ectopic expression of C/EBPalpha in the lung epithelium disrupts late lung development
    Tove Berg
    Division for Respiratory Medicine, Department of Medicine, Karolinska Institute, Lung Research Laboratory L4 01, Karolinska University Hospital Solna, Stockholm SE171 76, Sweden
    Am J Physiol Lung Cell Mol Physiol 291:L683-93. 2006
    ..In conclusion, our results show a role for C/EBPalpha in lung development and suggest a function in the later stages of lung branching morphogenesis...
  71. pmc α5β1 integrin-mediated adhesion to fibronectin is required for axis elongation and somitogenesis in mice
    Amparo Girós
    Departament de Bioquimica i Biologia Molecular, Universitat de Valencia, Burjassot, Spain
    PLoS ONE 6:e22002. 2011
    The arginine-glycine-aspartate (RGD) motif in fibronectin (FN) represents the major binding site for α5β1 and αvβ3 integrins...
  72. pmc Plasma fibronectin deficiency impedes atherosclerosis progression and fibrous cap formation
    Ina Rohwedder
    Department for Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany
    EMBO Mol Med 4:564-76. 2012
    ..The main cause of vascular occlusion is rupture of atheromatous lesions followed by thrombus formation. Fibronectin (FN) is one of the earliest ECM proteins deposited at atherosclerosis-prone sites and was suggested to promote ..
  73. pmc FibronectinEDA promotes chronic cutaneous fibrosis through Toll-like receptor signaling
    Swati Bhattacharyya
    Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Sci Transl Med 6:232ra50. 2014
    ..We now show that fibronectin extra domain A (Fn(EDA)) is an endogenous TLR4 ligand markedly elevated in the circulation and lesional skin ..
  74. pmc Cardiomyocyte contractile status is associated with differences in fibronectin and integrin interactions
    Xin Wu
    Dept of Systems Biology and Translational Medicine, Texas A and M Health Science Center College of Medicine, College Station, TX 77843 1114, USA
    Am J Physiol Heart Circ Physiol 298:H2071-81. 2010
    ..The purpose of this study was to characterize the interactions between the ECM protein fibronectin (FN) and integrins in cardiomyocytes and to test the hypothesis that these interactions would vary during ..
  75. pmc Phage-based molecular probes that discriminate force-induced structural states of fibronectin in vivo
    Lizhi Cao
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 313 Ferst Drive, Atlanta, GA 30332, USA
    Proc Natl Acad Sci U S A 109:7251-6. 2012
    ..The mechanism of such switches is thought to be the partial unfolding of integrin-binding domains within fibronectin (Fn)...
  76. doi TGF-beta-1 up-regulates extra-cellular matrix production in mouse hepatoblasts
    Daisuke Sugiyama
    Division of Hematopoietic Stem Cells, Advanced Medical Initiatives, Department of Advanced Medical Initiatives, Kyushu University Faculty of Medical Sciences, Fukuoka 812 8582, Japan
    Mech Dev 130:195-206. 2013
    ..Taken together, our observations suggest that hepatoblasts predominantly produce ECM factors under control of TGF-beta-1 in fetal liver...
  77. pmc Spatial and temporal analysis of extracellular matrix proteins in the developing murine heart: a blueprint for regeneration
    Kevin P Hanson
    Department of Biomedical Engineering, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Tissue Eng Part A 19:1132-43. 2013
    ..relative amount of the four essential ECM proteins, collagen types I and IV (COLI, COLIV), elastin (ELN), and fibronectin (FN) in the left ventricle of the murine heart at embryonic stages E12.5, E14.5, and E16...
  78. ncbi Soluble and cell-bound forms of steel factor activity play distinct roles in melanocyte precursor dispersal and survival on the lateral neural crest migration pathway
    B Wehrle-Haller
    Institute of Neuroscience, University of Oregon, Eugene 97403
    Development 121:731-42. 1995
    ..In contrast, membrane-bound Steel factor appears to promote melanocyte precursor survival in the dermis...
  79. ncbi Cell surface glycoconjugates and the extracellular matrix of the developing mouse embryo epicardium
    F Kalman
    Department of Pathology, Postgraduate Medical University, Budapest, Hungary
    Anat Embryol (Berl) 191:451-64. 1995
    ..are shown with cuprolinic blue, alcian blue and ruthenium red on the apical (outer) cell surface, while fibronectin and laminin are present on the basal (luminal) cell surface...
  80. ncbi Sequence of the mouse fibronectin-encoding gene promoter region
    P Polly
    Carcinogenesis Research Unit, School of Pathology, University of New South Wales, Sydney, Australia
    Gene 137:353-4. 1993
    ..The polymerase chain reaction (PCR) procedure has been utilised to clone, from mouse genomic DNA, a region of the fibronectin (FN)-encoding gene (FN) which includes the 5' flanking nucleotide (nt) sequences...
  81. ncbi Neural tube defects in embryos of diabetic mice: role of the Pax-3 gene and apoptosis
    S A Phelan
    Section on Molecular Biology, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes 46:1189-97. 1997
    ..This pathway may be responsible for many of the neural tube defects resulting from diabetic pregnancy...
  82. ncbi Regulated expression of tissue transglutaminase in Swiss 3T3 fibroblasts: effects on the processing of fibronectin, cell attachment, and cell death
    E Verderio
    Department of Life Sciences, Nottingham Trent University, United Kingdom
    Exp Cell Res 239:119-38. 1998
    ..antigen, one intracellular and the other extracellular, which has a cellular distribution comparable to fibronectin. Incubation of cells with the fluorescent tTgase substrate fluorescein cadaverine indicated incorporation only ..
  83. ncbi Sox4-deficiency syndrome in mice is an animal model for common trunk
    J Ya
    Department of Anatomy and Embryology, Academic Medical Center, University of Amsterdam, and the Department of Immunology, University of Utrecht, The Netherlands
    Circ Res 83:986-94. 1998
    ....
  84. ncbi Basal lamina molecules are concentrated in myogenic regions of the mouse limb bud
    E W Godfrey
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee 53225, USA
    Anat Embryol (Berl) 198:481-6. 1998
    ..stimulate the differentiation of skeletal muscle cells in culture, while interstitial matrix components such as fibronectin are inhibitory...
  85. ncbi TGF-beta3-null mutation does not abrogate fetal lung maturation in vivo by glucocorticoids
    W Shi
    Developmental Biology Program, Childrens Hospital Los Angeles and University of Southern California School of Medicine, Los Angeles 90027, California
    Am J Physiol 277:L1205-13. 1999
    ..glucocorticoids were able to promote lung maturation and increased expression of both tropoelastin and fibronectin but decreased the relative number of surfactant protein C-positive cells in fetal lungs of both genotypes...
  86. ncbi Foxp1 regulates cardiac outflow tract, endocardial cushion morphogenesis and myocyte proliferation and maturation
    Bin Wang
    Department of Molecular Genetics and The Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA
    Development 131:4477-87. 2004
    ....
  87. ncbi Prothrombotic effects of fibronectin isoforms containing the EDA domain
    Anil K Chauhan
    CBR Institute for Biomedical Research and the Department of Pathology, Harvard Medical School, Boston, Mass, USA
    Arterioscler Thromb Vasc Biol 28:296-301. 2008
    b>Fibronectin (FN) plays an important role in the formation of stable arterial thrombi at the site of vascular injury...
  88. pmc Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos
    Alexandre Trindade
    Centro de Informatica do Instituto Superior de Agronomia CIISA, Lisbon Technical University, Lisbon, Portugal
    Blood 112:1720-9. 2008
    ..mDll4 overexpression also inhibited VEGF signaling and increased fibronectin accumulation around the vessels...
  89. pmc SM22alpha-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis
    Nesrine El-Bizri
    Cardiopulmonary Research Program, Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford University School of Medicine, Stanford, California, CA, USA
    Development 135:2981-91. 2008
    ..Thus, loss of Bmpr1a, by decreasing MMP2 and/or MMP9 activity, can account for vascular dilatation and persistence of brain microvessels, leading to the impaired organogenesis documented in the brain...
  90. pmc Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli
    Rui Benedito
    Centro Interdisciplinar de Investigação em Sanidade Animal, Faculdade de Medicina Veterinaria, Technical University of Lisbon, Lisboa, Portugal
    BMC Dev Biol 8:117. 2008
    ..Dll4 null embryos die very early in development with severely reduced arterial calibre and lumen and loss of arterial cell identity...
  91. doi EphB2-mediated interactions are essential for proper migration of T cell progenitors during fetal thymus colonization
    Marco A Stimamiglio
    Department of Cell Biology, Faculty of Biology, Complutense University, C Jose Antonio Novais, sn, 28040 Madrid, Spain
    J Leukoc Biol 88:483-94. 2010
    ..Our data suggest the relevance of a nonactivated EphB2 for regulating T cell progenitor migration and its modulation upon ephrin-B engagement...
  92. pmc Blood flow dynamics of one cardiac cycle and relationship to mechanotransduction and trabeculation during heart looping
    Barbara Garita
    Department of Pediatrics, The Children s Research Institute, University of South Florida and All Children s Hospital, St Petersburg, USA
    Am J Physiol Heart Circ Physiol 300:H879-91. 2011
    ..Using image analyses, the organization of mechanotransducing molecules, fibronectin, tenascin C, α-tubulin, and nonmuscle myosin II was correlated with specific cardiac regions defined by OCT ..
  93. pmc Adhesion, migration, and homing of murine hematopoietic stem cells and progenitors
    Jose A Cancelas
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA
    Methods Mol Biol 750:187-96. 2011
    ..In this chapter, we analyze some of the most frequently used assays in our laboratory to explore the ability of HSC to migrate, adhere, and home in in vitro and in vivo assays...
  94. doi Deficiency in Crumbs homolog 2 (Crb2) affects gastrulation and results in embryonic lethality in mice
    Zhijie Xiao
    Department of Medical Biochemistry and Biophysics, Division of Matrix Biology, Karolinska Institutet, Stockholm, Sweden
    Dev Dyn 240:2646-56. 2011
    ..5. These findings therefore indicate a novel role for the Crumbs family of proteins...
  95. ncbi Mapping of Col3a1 and Col6a3 to proximal murine chromosome 1 identifies conserved linkage of structural protein genes between murine chromosome 1 and human chromosome 2q
    E Schurr
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Genomics 8:477-86. 1990
    ..The loci investigated were NEB/Neb, ELN/Eln, COL3A1/Col3a1, CRYG/Len-2, FN1/Fn-1, VIL/Vil, and COL6A3/Col6a3. Ren-1,2 and Acrg were included as two proximal mouse chromosome 1 anchor loci...
  96. ncbi Identification of two clusters of mouse insulin-like growth factor binding protein genes on chromosomes 1 and 11
    K Kou
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    Genomics 21:653-5. 1994
    ..These results suggest an evolutionary scheme in which a primordial IGFBP gene duplicated to form a cluster that was later replicated to create second linkage group...
  97. ncbi Cloning, expression, and chromosomal location of SHH and IHH: two human homologues of the Drosophila segment polarity gene hedgehog
    V Marigo
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genomics 28:44-51. 1995
    ..Shh mapped to a position 0.6 cM distal to En2 and 1.9 cM proximal to Il6 on mouse chromosome 5. This location is closely linked but distinct from the murine limb mutation Hx and syntenic to human chromosome 7q36...
  98. pmc The murine dilute suppressor gene encodes a cell autonomous suppressor
    K J Moore
    Mammalian Genetics Laboratory, ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Maryland 21702
    Genetics 138:491-7. 1994
    ..In addition, we have further refined the map location of dsu in order to examine a number of possible dsu candidate genes mapping in the region and to provide a genetic basis for the positional cloning of dsu...
  99. ncbi Cloning of the mouse fibronectin V-region and variation of its splicing pattern in experimental immune complex glomerulonephritis
    E C Bergijk
    Department of Pathology, University of Leiden, Netherlands
    J Pathol 178:462-8. 1996
    Increased mRNA and protein expression of extracellular matrix (ECM) components, including fibronectin, occurs during the development of glomerulonephritis and glomerulosclerosis in immunologically mediated kidney diseases...
  100. ncbi DNA hypomethylation can activate Xist expression and silence X-linked genes
    B Panning
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Genes Dev 10:1991-2002. 1996
    ....

Research Grants9

  1. ROLE OF FIBRONECTIN IN AIRWAY REMODELING IN ASTHMA
    DENISE HOCKING; Fiscal Year: 2002
    ..the architecture of the airway wall undergoes prominent structural changes, including increased deposition of fibronectin and collagen into the subepithelial region of the airway wall...
  2. FIBRONECTIN DEPOSITION AND PULMONARY FIBROSIS
    DENISE HOCKING; Fiscal Year: 2002
    ..by fibroblast proliferation and excessive accumulation of extracellular matrix proteins, including fibronectin and types I and III collagen...
  3. Extracellular Matrix Remodeling and Tissue Mechanics
    DENISE HOCKING; Fiscal Year: 2004
    ..Our data indicate that the polymerization of fibronectin into the extracellular matrix plays a unique role in regulating both cytoskeletal tension generation and ..
  4. Mechanisms of Tissue Remodeling By Ultrasound
    DENISE HOCKING; Fiscal Year: 2004
    ..on biochemically characterizing the effects of ultrasound on the deposition and structural organization of fibronectin and collagen I fibrils in the extracellular matrix...
  5. Ultrasound Technologies for Tissue Engineering
    DENISE C contact HOCKING; Fiscal Year: 2010
    ..End of Abstract) ..
  6. FN FAK SIGNALING AXIS AND TUMORIGENESIS
    Dusko Ilic; Fiscal Year: 2004
    ..rather than formation, and that FAK deficiency in mice results in a phenotype remarkably similar to that of fibronectin (FN) deficiency. In the Damsky lab Dr...
  7. Cardiac Teratogenicity of Lithium
    Kersti Linask; Fiscal Year: 2004
    ..Until the safety of lithium is conclusively proven, one must assume teratogenic potential and harm to the fetus. ..
  8. THE ROLE OF SRF IN CARDIAC FUNCTION AND DEVELOPMENT
    RAVINDRA MISRA; Fiscal Year: 2005
    ..These studies will both elucidate the mechanisms by which SRF functions in heart and will establish powerful new methodologies for studying heart formation and function. ..
  9. Transcriptional Control of Early Coronary Vascular Development
    RAVINDRA P MISRA; Fiscal Year: 2010
    ....