Genomes and Genes
Gene Symbol: Fn1
Description: fibronectin 1
Alias: E330027I09, Fn-1, fibronectin
Publications132 found, 100 shown here
- Mesodermal development in mouse embryos mutant for fibronectinE N Georges-Labouesse
Howard Hughes Medical Institute, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139, USA
Dev Dyn 207:145-56. 1996Three independent mutations were made by homologous recombination in two different regions of the fibronectin (FN) gene; all three appeared to be functional null mutations...
- Hyperglycemia-induced TGFbeta and fibronectin expression in embryonic mouse heartIda Washington Smoak
Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, North Carolina
Dev Dyn 231:179-89. 2004..was to characterize TGF beta expression in the organogenesis-stage mouse heart and to evaluate TGF beta and fibronectin expression in embryonic mouse heart exposed to hyperglycemia...
- Isolation and characterization of a large soluble form of fibronectin that stimulates adhesion, spreading, and alignment of mouse erythroleukemia cellsBarbara M Scher
Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
Exp Cell Res 316:2402-13. 2010b>Fibronectin (FN) is a major component of the extracellular matrix which plays important roles in a variety of cellular processes including cell adhesion, and migration...
- Biologically active fibronectin fragments stimulate release of MCP-1 and catabolic cytokines from murine retinal pigment epitheliumBobbie Ann Austin
National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
Invest Ophthalmol Vis Sci 50:2896-902. 2009..In the present study, the authors focused on a substrate of HTRA1, fibronectin, because fibronectin fragments (Fnfs) stimulate biochemical events in other age-related degenerative diseases ..
- Identification and mapping of six microdissected genomic DNA probes to the proximal region of mouse chromosome 1S M Vidal
Department of Biochemistry, McGill University, Montreal, Canada
Genomics 14:32-7. 1992..These novel polymorphic probes should prove useful for linkage and physical mapping of this chromosomal region...
- Mapping of mouse gamma crystallin genes on chromosome 1L C Skow
Department of Veterinary Anatomy, College of Veterinary Medicine, Texas A and M University, College Station 77843 4458
Biochem Genet 26:557-70. 1988..isocitrate dehydrogenase (Idh-1), a low molecular weight (LM) crystallin protein polymorphism (Len-1), and fibronectin (Fn-1)...
- Regional localization of the fibronectin and gamma crystallin genes to mouse chromosome 1 by in situ hybridizationS M Zneimer
Department of Veterinary Pathology, College of Veterinary Medicine, Texas A and M University, College Station 77843
Cytogenet Cell Genet 48:238-41. 1988Genes for fibronectin, gamma crystallin, and isocitrate dehydrogenase-1 are syntenic in mouse, man, and cow...
- Changing patterns of cell adhesion molecules during mouse pelage hair follicle development. 1. Follicle morphogenesis in wild-type miceM H Hardy
Department of Biomedical Sciences, University of Guelph, Ont, Canada
Acta Anat (Basel) 157:169-82. 1996..The results suggest that the main role of cell adhesion molecules is to mould the follicle by relaxing or reinforcing cell contacts in areas of increased morphogenetic activity...
- Ultrastructural localization of microfibrillar fibulin-1 and fibulin-2 during heart development indicates a switch in molecular associationsN Miosge
Abteilung Histologie, Universitat Gottingen, Germany
Cell Mol Life Sci 54:606-13. 1998..has now been used to compare their localization in embryonic (days 9-11) and adult mouse heart with that of fibronectin and the chondroitin sulphate proteoglycan versican...
- Perinatal lethality and endothelial cell abnormalities in several vessel compartments of fibulin-1-deficient miceG Kostka
Max Planck Institut fur Biochemie, D 82152 Martinsried, Germany
Mol Cell Biol 21:7025-34. 2001..The data indicate a strong but restricted abnormality in some endothelial compartments which, together with some kidney and lung defects, may be responsible for early death...
- Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1Nathan V Lee
Department of Molecular, Cell, and Developmental Biology and Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California 90095, USA
J Biol Chem 280:34796-804. 2005..Together, these findings indicate that fibulin-1 is a new regulator of ADAMTS-1-mediated proteoglycan proteolysis and thus may play an important role in proteoglycan turnover in tissues where there is overlapping expression...
- Increased expression of fibronectin and the alpha 5 beta 1 integrin in angiogenic cerebral blood vessels of mice subject to hypobaric hypoxiaRichard Milner
Department of Molecular and Experimental Medicine, MEM 132, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Mol Cell Neurosci 38:43-52. 2008..We showed previously that angiogenic capillaries in the developing CNS express high levels of fibronectin and its receptor alpha5beta1 integrin, and that this expression is developmentally downregulated...
- Fibulin-1 is required for morphogenesis of neural crest-derived structuresMarion A Cooley
Department of Cell Biology and Anatomy, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
Dev Biol 319:336-45. 2008....
- Pref-1 interacts with fibronectin to inhibit adipocyte differentiationYuhui Wang
Department of Nutritional Science and Toxicology, University of California, Berkeley, CA 94720, USA
Mol Cell Biol 30:3480-92. 2010..Instead, we show a direct interaction of Pref-1 and fibronectin via the Pref-1 juxtamembrane domain and fibronectin C-terminal domain...
- Localization of types I and III collagen and fibronectin in the developing mouse palatal shelvesY Ohsaki
Second Department of Oral Anatomy, Kyushu University, Fukuoka, Japan
Acta Anat (Basel) 153:161-7. 1995The detailed distribution of types I and III collagen and fibronectin was studied in the developing mouse palatal shelf using a double immunofluorescence technique...
- Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrinsB L Bader
Howard Hughes Medical Institute, Center for Cancer Research, Cambridge, Massachusetts 02139, USA
Cell 95:507-19. 1998..These results necessitate reevaluation of the primacy of alphav integrins in many functions including vascular development, despite reports that blockade of these integrins with antibodies or peptides prevents angiogenesis...
- Overlapping and independent functions of fibronectin receptor integrins in early mesodermal developmentJ T Yang
Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Dev Biol 215:264-77. 1999Mouse embryos deficient in fibronectin (FN-null) die at E8.5 with mesodermal defects. Eight integrin heterodimers alpha3beta1, alpha4beta1, alpha5beta1, alpha8beta1, alphavbeta1, alphavbeta3, alphavbeta6, and alphaIIbbeta3 can bind to FN...
- A cryptic fragment from fibronectin's III1 module localizes to lipid rafts and stimulates cell growth and contractilityDenise C Hocking
Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA
J Cell Biol 158:175-84. 2002The interaction of cells with the extracellular matrix (ECM) form of fibronectin (FN) triggers changes in growth, migration, and cytoskeletal organization that differ from those generated by soluble FN...
- Fibrillin-1 microfibril deposition is dependent on fibronectin assemblyRachel Kinsey
Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Science, Michael Smith Building, Oxford Road, University of Manchester, Manchester M139PT, UK
J Cell Sci 121:2696-704. 2008Newly deposited microfibrils strongly colocalise with fibronectin in primary fibroblasts. Microfibril formation is grossly inhibited by fibronectin depletion, but rescued by supplementation with exogenous cellular fibronectin...
- Endothelial alpha5 and alphav integrins cooperate in remodeling of the vasculature during developmentArjan van der Flier
Howard Hughes Medical Institute, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Development 137:2439-49. 2010Integrin cell adhesion receptors and fibronectin, one of their extracellular matrix ligands, have been demonstrated to be important for angiogenesis using functional perturbation studies and complete knockout mouse models...
- Essential roles of fibronectin in the development of the left-right embryonic body planMaria V Pulina
Weill Cornell Medical College, Department of Medicine, Division of Cardiology, New York, NY, USA
Dev Biol 354:208-20. 2011..Taken together, our studies demonstrate the requisite role for a structural ECM protein and its integrin receptor in the development of the left-right axis of asymmetry in vertebrates...
- Mice develop normally without tenascinY Saga
Laboratory of Cell Biology, Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
Genes Dev 6:1821-31. 1992..histological abnormalities were detected in any tissues, and no major changes were observed in distribution of fibronectin, laminin, collagen, and proteoglycan...
- Tenascin during gut development: appearance in the mesenchyme, shift in molecular forms, and dependence on epithelial-mesenchymal interactionsE Aufderheide
Friederich Miescher Laboratorium der Max Planck Gesellschaft, Tubingen, Federal Republic of Germany
J Cell Biol 107:2341-9. 1988..We propose that growing and differentiating epithelia produce locally active factors which stimulate synthesis of tenascin in the surrounding mesenchyme...
- Alternative splicing of fibronectin--many different proteins but few different functionsC ffrench-Constant
Wellcome CRC Institute of Developmental Biology and Cancer, Cambridge, United Kingdom
Exp Cell Res 221:261-71. 1995
- Embryonic mesodermal defects in alpha 5 integrin-deficient miceJ T Yang
Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139
Development 119:1093-105. 1993..However, the embryos progress significantly further than embryos null for fibronectin, for which alpha 5 beta 1 integrin is a receptor, suggesting the involvement of other fibronectin receptors...
- Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectinE L George
Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139
Development 119:1079-91. 1993To examine the role of fibronectin in vivo, we have generated mice in which the fibronectin gene is inactivated. Heterozygotes have one half normal levels of plasma fibronectin, yet appear normal...
- Fibronectin isoform distribution in the mouse. I. The alternatively spliced EIIIB, EIIIA, and V segments show widespread codistribution in the developing mouse embryoJ H Peters
Division of Pulmonary Medicine, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
Cell Adhes Commun 4:103-25. 1996..Conversely, these segments would appear to play divergent, and sometimes exclusive, biological roles in specific tissues such as liver, cartilage, and placenta...
- Fibronectins are essential for heart and blood vessel morphogenesis but are dispensable for initial specification of precursor cellsE L George
Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Blood 90:3073-81. 1997The underlying mechanisms of lethal cardiovascular defects associated with the fibronectin-null (FN.null) mutation in mouse embryos were investigated by lineage analysis of myocardial, endocardial, and endothelial cells...
- Cleft palate formation in fetal Br mice with midfacial retrusion: tenascin, fibronectin, laminin, and type IV collagen immunolocalizationG D Singh
Department of Dental Surgery and Periodontology, Dundee Dental Hospital and School, University of Dundee, Scotland, UK
Cleft Palate Craniofac J 35:65-76. 1998..altered craniofacial morphology does not affect the expression of extracellular matrix (ECM) molecules such as fibronectin (FN), laminin (LN), type IV collagen, and tenascin-C (TN) but is associated with failure of palatal shelf ..
- A test of the role of alpha5 integrin/fibronectin interactions in tumorigenesisD Taverna
Howard Hughes Medical Institute and Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
Cancer Res 58:848-53. 1998Published data show that reduction or loss of fibronectin or its receptor, alpha5beta1 integrin, occurs frequently in tumors and transformed cells...
- Regulation of the fibronectin EDA exon alternative splicing. Cooperative role of the exonic enhancer element and the 5' splicing siteA F Muro
International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
FEBS Lett 437:137-41. 1998..The EDA exon of the fibronectin gene is a typical example of an exon bearing a purine-rich exon splicing enhancer (ESE) element recognised by ..
- Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart developmentH M Arthur
SMIVS, School of Biochemistry and Genetics, United Kingdom
Dev Biol 217:42-53. 2000..We anticipate that heterozygous mice will ultimately serve as a useful disease model for HHT1, as some individuals have dilated and fragile blood vessels similar to vascular malformations seen in HHT patients...
- Disruption of the talin gene arrests mouse development at the gastrulation stageS J Monkley
Department of Biochemistry, University of Leicester, University Road, Leicester, United Kingdom
Dev Dyn 219:560-74. 2000..Spreading of trophoblast cells derived from cultured mutant blastocysts on fibronectin and laminin is also considerably reduced...
- Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasisT Sakai
Department of Experimental Pathology, Lund University, Lund, Sweden
Nat Med 7:324-30. 2001b>Fibronectin performs essential roles in embryonic development and is prominently expressed during tissue repair...
- The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesisJ Oh
Department of Molecular Oncology, Kyoto University Graduate School of Medicine, 606 8501, Kyoto, Japan
Cell 107:789-800. 2001..These results support a role for RECK in the regulation of MMP-2 in vivo and implicate RECK downregulation in tumor angiogenesis...
- Dual functions of [alpha]4[beta]1 integrin in epicardial development: initial migration and long-term attachmentJennifer K Sengbusch
Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Cell Biol 157:873-82. 2002..T., H. Rayburn, and R.O. Hynes. 1995. Development. 121:549-560)...
- Mice lacking the EDB segment of fibronectin develop normally but exhibit reduced cell growth and fibronectin matrix assembly in vitroTomohiko Fukuda
Institute for Protein Research, Osaka University, Suita, Osaka 565 0871, Japan
Cancer Res 62:5603-10. 2002..These results indicate that expression of EDB-containing isoforms is dispensable during embryonic development, yet may play a modulating role in the growth of connective tissue cells via the FN matrix...
- Plasma fibronectin promotes thrombus growth and stability in injured arteriolesHeyu Ni
Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 100:2415-9. 2003..The platelets of these animals accumulate excessive amounts of fibronectin (FN). These observations led us to examine the contribution of plasma FN (pFN) to thrombus formation...
- Fibronectin matrix polymerization regulates small airway epithelial cell migrationDenise C Hocking
Department of Pharmacologyand physiology, University of Rochester Medical Center, 601 Elmwood Ave, Box 711, Rochester, NY 14642, USA
Am J Physiol Lung Cell Mol Physiol 285:L169-79. 2003The continuous conversion of soluble fibronectin into extracellular matrix fibrils occurs through a dynamic, cell-dependent process...
- Increased fibronectin deposition in embryonic hearts of retinol-binding protein-null miceChristopher C Wendler
Department of Cell Biology, Neurobiology and Anatomy and the Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
Circ Res 92:920-8. 2003..Most remarkably, RBP-null hearts display augmented deposition of fibronectin protein in the cardiac jelly at E9.0 through E10.5 and in the outflow tract at E12.5...
- Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talinGuoying Jiang
Department of Biological Sciences, Columbia University, 1212 Amsterdam Avenue, New York, New York 11027, USA
Nature 424:334-7. 2003..The minimal matrix complex causing integrin-cytoskeleton connections is a trimer of fibronectin's integrin-binding domain FNIII7-10 (ref. 4)...
- Deletion of the alternatively spliced fibronectin EIIIA domain in mice reduces atherosclerosisMichelle H Tan
Vascular Research Division, Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
Blood 104:11-8. 2004The alternatively spliced and highly conserved EIIIA domain of fibronectin (FN) is included in most FN of the extracellular matrix in embryos. In adults, both extracellular matrix and plasma FN essentially lack EIIIA...
- Direct test of potential roles of EIIIA and EIIIB alternatively spliced segments of fibronectin in physiological and tumor angiogenesisSophie Astrof
Howard Hughes Medical Institute, Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Mol Cell Biol 24:8662-70. 2004b>Fibronectin splice variants containing the EIIIA and/or EIIIB exons are prominently expressed in the vasculature of a variety of human tumors but not in normal adult tissues...
- Transforming growth factor beta-SMAD2 signaling regulates aortic arch innervation and developmentDaniel G M Molin
Department of Anatomy and Embryology, Leiden University Medical Center, PO Box 9602, 2300 RC Leiden, The Netherlands
Circ Res 95:1109-17. 2004..For diminished transforming growth factor beta (TGF-beta) signaling, SMAD2 and fibronectin have been analyzed...
- Fibronectin regulates latent transforming growth factor-beta (TGF beta) by controlling matrix assembly of latent TGF beta-binding protein-1Sarah L Dallas
Department of Oral Biology, School of Dentistry, University of Missouri, Kansas City, Missouri 64108, USA
J Biol Chem 280:18871-80. 2005..Here we show that fibronectin is critical for the incorporation of LTBP1 and transforming growth factor-beta (TGF beta) into the ECM of ..
- Fibronectin is required for integrin alphavbeta6-mediated activation of latent TGF-beta complexes containing LTBP-1Laura Fontana
Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
FASEB J 19:1798-808. 2005..The LTBP-1 polypeptide rL1N, which includes the hinge, associates with fibronectin in binding assays...
- pVHL function is essential for endothelial extracellular matrix depositionNan Tang
Molecular Biology Section, MC 0377, Division of Biological Sciences, University of California San Diego, La Jolla, California 92093 0377, USA
Mol Cell Biol 26:2519-30. 2006..The defects in embryonic vascularization were correlated with a diminished vascular fibronectin deposition in vivo and defective endothelial extracellular fibronectin assembly in vitro...
- Spontaneous formation of L-isoaspartate and gain of function in fibronectinFlavio Curnis
Department of Oncology, Cancer Immunotherapy and Gene Therapy Program and Italian Institute of Technology Network Research Unit of Molecular Neuroscience, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
J Biol Chem 281:36466-76. 2006..In particular, we show that deamidation of Asn263 at the Asn-Gly-Arg (NGR) site in fibronectin N-terminal region generates an alpha(v)beta3-integrin binding site containing the L-isoDGR sequence, which is ..
- The ECM protein nephronectin promotes kidney development via integrin alpha8beta1-mediated stimulation of Gdnf expressionJames M Linton
Department of Physiology, 1550 Fourth Street, University of California, San Francisco, San Francisco, CA 94143, USA
Development 134:2501-9. 2007..Our results thus place nephronectin and alpha8beta1 integrin in a pathway that regulates Gdnf expression and is essential for kidney development...
- The RGD motif in fibronectin is essential for development but dispensable for fibril assemblySeiichiro Takahashi
Max Planck Institute of Biochemistry, Department of Molecular Medicine, 82152 Martinsried, Germany
J Cell Biol 178:167-78. 2007b>Fibronectin (FN) is secreted as a disulfide-bonded FN dimer. Each subunit contains three types of repeating modules: FN-I, FN-II, and FN-III...
- A major fraction of fibronectin present in the extracellular matrix of tissues is plasma-derivedFederico A Moretti
International Centre for Genetic Engineering and Biotechnology, 34012 Trieste, Italy
J Biol Chem 282:28057-62. 2007The origin of the fibronectin (FN) found in the extracellular matrix of tissues has not been defined experimentally...
- Alteration of medial-edge epithelium cell adhesion in two Tgf-beta3 null mouse strainsElena Martínez-Sanz
Departamento de Anatomía y Embriología Humana I, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain
Differentiation 76:417-30. 2008..We have performed immunohistochemistry with antibodies against collagens IV and IX, laminin, fibronectin, the alpha5- and beta1-integrins, and ICAM-1; in situ hybridization with a Nectin-1 riboprobe; and palatal ..
- Fibronectin binds and enhances the activity of bone morphogenetic protein 1Guorui Huang
Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA
J Biol Chem 284:25879-88. 2009..Such processing includes proteolytic activation of the zymogen for lysyl oxidase. Fibronectin (FN) is an abundant protein component of the ECM that is capable of regulating manifold cellular functions ..
- Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethalityXingqun Liang
Department of Medicine, University of California at San Diego, La Jolla, CA 92093 0613, USA
Circulation 120:568-76. 2009..A potential role for PINCH proteins in myocardium remains unknown...
- Circulating fibronectin affects bone matrix, whereas osteoblast fibronectin modulates osteoblast functionAnke Bentmann
Max Planck Institute for Biochemistry, 82152 Martinsried, Germany
J Bone Miner Res 25:706-15. 2010The bone matrix is composed mostly of collagen, but the initial and continuous presence of fibronectin was found to be crucial for collagen matrix integrity in vitro...
- Fibronectin and integrin alpha 5 play essential roles in the development of the cardiac neural crestAshok Mittal
Weill Cornell Medical College, Department of Medicine, Division of Cardiology, New York, NY, USA
Mech Dev 127:472-84. 2010..b>Fibronectin (FN) protein is present along neural crest migration paths and neural crest cells migrate when plated on FN in ..
- A fibronectin-independent mechanism of collagen fibrillogenesis in adult liver remodelingKei Moriya
Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
Gastroenterology 140:1653-63. 2011..Although it has been proposed that collagen organization and assembly depend on the fibronectin matrix in culture, the contribution of fibronectin to these processes remains to be defined in vivo.
- Lack of fibronectin-EDA promotes survival and prevents adverse remodeling and heart function deterioration after myocardial infarctionFatih Arslan
Laboratory of Experimental Cardiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
Circ Res 108:582-92. 2011..The extracellular matrix protein fibronectin-EDA (EIIIA; EDA) is upregulated after tissue injury and may act as a "danger signal" for leukocytes to cause ..
- Fibronectin protects from excessive liver fibrosis by modulating the availability of and responsiveness of stellate cells to active TGF-βNina Kawelke
Translational Medicine, Max Planck Institute for Biochemistry, Martinsried, Germany
PLoS ONE 6:e28181. 2011Fibrotic tissue in the liver is mainly composed of collagen. Fibronectin, which is also present in fibrotic matrices, is required for collagen matrix assembly in vitro...
- An essential requirement for β1 integrin in the assembly of extracellular matrix proteins within the vascular wallKirsten A Turlo
Department of Molecular, Cellular, and Developmental Biology, University of California, Los Angeles, CA 90095, USA
Dev Biol 365:23-35. 2012..It further establishes a critical role of β1 integrin in the protection against aneurysms that is particularly confined to the ascending aorta and its branches...
- Putative functions of extracellular matrix glycoproteins in secondary palate morphogenesisRocca d'Amaro
Department of Orthodontics and Dentofacial Orthopedics, School of Dental Medicine, University of Bern Bern, Switzerland
Front Physiol 3:377. 2012..These provide substrates for cell adhesion (e.g., fibronectin, tenascins), but also regulate growth factor availability (e.g., fibrillins)...
- Circulating fibronectin controls tumor growthAnja von Au
Max Planck Institute of Biochemistry, Martinsried, Germany
Neoplasia 15:925-38. 2013b>Fibronectin is ubiquitously expressed in the extracellular matrix, and experimental evidence has shown that it modulates blood vessel formation...
- Binding of soluble fibronectin to integrin alpha5 beta1 - link to focal adhesion redistribution and contractile shapeStephan Huveneers
Division of Toxicology, Leiden Amsterdam Center for Drug Research, Einsteinweg 55, Leiden University, Leiden CC, The Netherlands
J Cell Sci 121:2452-62. 2008..Extensive remodeling of adhesions in fibroblasts also takes part in fibronectin fibrillogenesis, a process that depends on Rho-mediated contractility and results in the formation of a ..
- Cell adhesion events mediated by alpha 4 integrins are essential in placental and cardiac developmentJ T Yang
Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139, USA
Development 121:549-60. 1995..cell surface receptors that mediate cell-extracellular matrix (ECM) and cell-cell adhesions by interacting with fibronectin (FN) and vascular cell adhesion molecule 1 (VCAM-1), respectively...
- Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt signaling in branching morphogenesis of the mouse embryonic lungStijn P De Langhe
Developmental Biology Program, Department of Surgery, USC Keck School of Medicine and the Saban Research Institute of Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
Dev Biol 277:316-31. 2005..These defects coincide with a pattern of decreased fibronectin (FN) deposition...
- Splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3D J Epstein
Department of Biology, McGill University, Montreal, Canada
Cell 67:767-74. 1991..Our study provides evidence for a causal link between deletion of the paired homeodomain of Pax-3 and the Sp2H mutation, and infers that Pax-3 plays a key role in normal neural development...
- Distinct adhesive behaviors of neurons and neural precursor cells during regional differentiation in the mammalian forebrainJ G Whitesides
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Dev Biol 169:229-41. 1995..These differences are transient and can only be detected in the telencephalic vesicle before and during the morphogenesis of rudiments of major forebrain subdivisions...
- Chromosomal location of the murine anion exchanger genes encoding AE2 and AE3R A White
Section of Genetics, Children s Mercy Hospital, Kansas City, Missouri
Mamm Genome 5:827-9. 1994
- The developing mouse thyroid: embryonic vessel contacts and parenchymal growth pattern during specification, budding, migration, and lobulationHenrik Fagman
Institute of Anatomy and Cell Biology, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
Dev Dyn 235:444-55. 2006..It is suggested that thyroid inductive signals arise from embryonic vessels, and that this provides ideas to conceptually new pathogenetic mechanisms of thyroid dysgenesis...
- Ectopic expression of C/EBPalpha in the lung epithelium disrupts late lung developmentTove Berg
Division for Respiratory Medicine, Department of Medicine, Karolinska Institute, Lung Research Laboratory L4 01, Karolinska University Hospital Solna, Stockholm SE171 76, Sweden
Am J Physiol Lung Cell Mol Physiol 291:L683-93. 2006..In conclusion, our results show a role for C/EBPalpha in lung development and suggest a function in the later stages of lung branching morphogenesis...
- α5β1 integrin-mediated adhesion to fibronectin is required for axis elongation and somitogenesis in miceAmparo Girós
Departament de Bioquimica i Biologia Molecular, Universitat de Valencia, Burjassot, Spain
PLoS ONE 6:e22002. 2011The arginine-glycine-aspartate (RGD) motif in fibronectin (FN) represents the major binding site for α5β1 and αvβ3 integrins...
- Plasma fibronectin deficiency impedes atherosclerosis progression and fibrous cap formationIna Rohwedder
Department for Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany
EMBO Mol Med 4:564-76. 2012..The main cause of vascular occlusion is rupture of atheromatous lesions followed by thrombus formation. Fibronectin (FN) is one of the earliest ECM proteins deposited at atherosclerosis-prone sites and was suggested to promote ..
- FibronectinEDA promotes chronic cutaneous fibrosis through Toll-like receptor signalingSwati Bhattacharyya
Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Sci Transl Med 6:232ra50. 2014..We now show that fibronectin extra domain A (Fn(EDA)) is an endogenous TLR4 ligand markedly elevated in the circulation and lesional skin ..
- Cardiomyocyte contractile status is associated with differences in fibronectin and integrin interactionsXin Wu
Dept of Systems Biology and Translational Medicine, Texas A and M Health Science Center College of Medicine, College Station, TX 77843 1114, USA
Am J Physiol Heart Circ Physiol 298:H2071-81. 2010..The purpose of this study was to characterize the interactions between the ECM protein fibronectin (FN) and integrins in cardiomyocytes and to test the hypothesis that these interactions would vary during ..
- Phage-based molecular probes that discriminate force-induced structural states of fibronectin in vivoLizhi Cao
Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 313 Ferst Drive, Atlanta, GA 30332, USA
Proc Natl Acad Sci U S A 109:7251-6. 2012..The mechanism of such switches is thought to be the partial unfolding of integrin-binding domains within fibronectin (Fn)...
- TGF-beta-1 up-regulates extra-cellular matrix production in mouse hepatoblastsDaisuke Sugiyama
Division of Hematopoietic Stem Cells, Advanced Medical Initiatives, Department of Advanced Medical Initiatives, Kyushu University Faculty of Medical Sciences, Fukuoka 812 8582, Japan
Mech Dev 130:195-206. 2013..Taken together, our observations suggest that hepatoblasts predominantly produce ECM factors under control of TGF-beta-1 in fetal liver...
- Spatial and temporal analysis of extracellular matrix proteins in the developing murine heart: a blueprint for regenerationKevin P Hanson
Department of Biomedical Engineering, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
Tissue Eng Part A 19:1132-43. 2013..relative amount of the four essential ECM proteins, collagen types I and IV (COLI, COLIV), elastin (ELN), and fibronectin (FN) in the left ventricle of the murine heart at embryonic stages E12.5, E14.5, and E16...
- Soluble and cell-bound forms of steel factor activity play distinct roles in melanocyte precursor dispersal and survival on the lateral neural crest migration pathwayB Wehrle-Haller
Institute of Neuroscience, University of Oregon, Eugene 97403
Development 121:731-42. 1995..In contrast, membrane-bound Steel factor appears to promote melanocyte precursor survival in the dermis...
- Cell surface glycoconjugates and the extracellular matrix of the developing mouse embryo epicardiumF Kalman
Department of Pathology, Postgraduate Medical University, Budapest, Hungary
Anat Embryol (Berl) 191:451-64. 1995..are shown with cuprolinic blue, alcian blue and ruthenium red on the apical (outer) cell surface, while fibronectin and laminin are present on the basal (luminal) cell surface...
- Sequence of the mouse fibronectin-encoding gene promoter regionP Polly
Carcinogenesis Research Unit, School of Pathology, University of New South Wales, Sydney, Australia
Gene 137:353-4. 1993..The polymerase chain reaction (PCR) procedure has been utilised to clone, from mouse genomic DNA, a region of the fibronectin (FN)-encoding gene (FN) which includes the 5' flanking nucleotide (nt) sequences...
- Neural tube defects in embryos of diabetic mice: role of the Pax-3 gene and apoptosisS A Phelan
Section on Molecular Biology, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Diabetes 46:1189-97. 1997..This pathway may be responsible for many of the neural tube defects resulting from diabetic pregnancy...
- Regulated expression of tissue transglutaminase in Swiss 3T3 fibroblasts: effects on the processing of fibronectin, cell attachment, and cell deathE Verderio
Department of Life Sciences, Nottingham Trent University, United Kingdom
Exp Cell Res 239:119-38. 1998..antigen, one intracellular and the other extracellular, which has a cellular distribution comparable to fibronectin. Incubation of cells with the fluorescent tTgase substrate fluorescein cadaverine indicated incorporation only ..
- Sox4-deficiency syndrome in mice is an animal model for common trunkJ Ya
Department of Anatomy and Embryology, Academic Medical Center, University of Amsterdam, and the Department of Immunology, University of Utrecht, The Netherlands
Circ Res 83:986-94. 1998....
- Basal lamina molecules are concentrated in myogenic regions of the mouse limb budE W Godfrey
Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee 53225, USA
Anat Embryol (Berl) 198:481-6. 1998..stimulate the differentiation of skeletal muscle cells in culture, while interstitial matrix components such as fibronectin are inhibitory...
- TGF-beta3-null mutation does not abrogate fetal lung maturation in vivo by glucocorticoidsW Shi
Developmental Biology Program, Childrens Hospital Los Angeles and University of Southern California School of Medicine, Los Angeles 90027, California
Am J Physiol 277:L1205-13. 1999..glucocorticoids were able to promote lung maturation and increased expression of both tropoelastin and fibronectin but decreased the relative number of surfactant protein C-positive cells in fetal lungs of both genotypes...
- Foxp1 regulates cardiac outflow tract, endocardial cushion morphogenesis and myocyte proliferation and maturationBin Wang
Department of Molecular Genetics and The Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA
Development 131:4477-87. 2004....
- Prothrombotic effects of fibronectin isoforms containing the EDA domainAnil K Chauhan
CBR Institute for Biomedical Research and the Department of Pathology, Harvard Medical School, Boston, Mass, USA
Arterioscler Thromb Vasc Biol 28:296-301. 2008b>Fibronectin (FN) plays an important role in the formation of stable arterial thrombi at the site of vascular injury...
- Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryosAlexandre Trindade
Centro de Informatica do Instituto Superior de Agronomia CIISA, Lisbon Technical University, Lisbon, Portugal
Blood 112:1720-9. 2008..mDll4 overexpression also inhibited VEGF signaling and increased fibronectin accumulation around the vessels...
- SM22alpha-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesisNesrine El-Bizri
Cardiopulmonary Research Program, Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford University School of Medicine, Stanford, California, CA, USA
Development 135:2981-91. 2008..Thus, loss of Bmpr1a, by decreasing MMP2 and/or MMP9 activity, can account for vascular dilatation and persistence of brain microvessels, leading to the impaired organogenesis documented in the brain...
- Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuliRui Benedito
Centro Interdisciplinar de Investigação em Sanidade Animal, Faculdade de Medicina Veterinaria, Technical University of Lisbon, Lisboa, Portugal
BMC Dev Biol 8:117. 2008..Dll4 null embryos die very early in development with severely reduced arterial calibre and lumen and loss of arterial cell identity...
- EphB2-mediated interactions are essential for proper migration of T cell progenitors during fetal thymus colonizationMarco A Stimamiglio
Department of Cell Biology, Faculty of Biology, Complutense University, C Jose Antonio Novais, sn, 28040 Madrid, Spain
J Leukoc Biol 88:483-94. 2010..Our data suggest the relevance of a nonactivated EphB2 for regulating T cell progenitor migration and its modulation upon ephrin-B engagement...
- Blood flow dynamics of one cardiac cycle and relationship to mechanotransduction and trabeculation during heart loopingBarbara Garita
Department of Pediatrics, The Children s Research Institute, University of South Florida and All Children s Hospital, St Petersburg, USA
Am J Physiol Heart Circ Physiol 300:H879-91. 2011..Using image analyses, the organization of mechanotransducing molecules, fibronectin, tenascin C, α-tubulin, and nonmuscle myosin II was correlated with specific cardiac regions defined by OCT ..
- Adhesion, migration, and homing of murine hematopoietic stem cells and progenitorsJose A Cancelas
Division of Experimental Hematology and Cancer Biology, Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA
Methods Mol Biol 750:187-96. 2011..In this chapter, we analyze some of the most frequently used assays in our laboratory to explore the ability of HSC to migrate, adhere, and home in in vitro and in vivo assays...
- Deficiency in Crumbs homolog 2 (Crb2) affects gastrulation and results in embryonic lethality in miceZhijie Xiao
Department of Medical Biochemistry and Biophysics, Division of Matrix Biology, Karolinska Institutet, Stockholm, Sweden
Dev Dyn 240:2646-56. 2011..5. These findings therefore indicate a novel role for the Crumbs family of proteins...
- Mapping of Col3a1 and Col6a3 to proximal murine chromosome 1 identifies conserved linkage of structural protein genes between murine chromosome 1 and human chromosome 2qE Schurr
Department of Biochemistry, McGill University, Montreal, Quebec, Canada
Genomics 8:477-86. 1990..The loci investigated were NEB/Neb, ELN/Eln, COL3A1/Col3a1, CRYG/Len-2, FN1/Fn-1, VIL/Vil, and COL6A3/Col6a3. Ren-1,2 and Acrg were included as two proximal mouse chromosome 1 anchor loci...
- Identification of two clusters of mouse insulin-like growth factor binding protein genes on chromosomes 1 and 11K Kou
Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
Genomics 21:653-5. 1994..These results suggest an evolutionary scheme in which a primordial IGFBP gene duplicated to form a cluster that was later replicated to create second linkage group...
- Cloning, expression, and chromosomal location of SHH and IHH: two human homologues of the Drosophila segment polarity gene hedgehogV Marigo
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
Genomics 28:44-51. 1995..Shh mapped to a position 0.6 cM distal to En2 and 1.9 cM proximal to Il6 on mouse chromosome 5. This location is closely linked but distinct from the murine limb mutation Hx and syntenic to human chromosome 7q36...
- The murine dilute suppressor gene encodes a cell autonomous suppressorK J Moore
Mammalian Genetics Laboratory, ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Maryland 21702
Genetics 138:491-7. 1994..In addition, we have further refined the map location of dsu in order to examine a number of possible dsu candidate genes mapping in the region and to provide a genetic basis for the positional cloning of dsu...
- Cloning of the mouse fibronectin V-region and variation of its splicing pattern in experimental immune complex glomerulonephritisE C Bergijk
Department of Pathology, University of Leiden, Netherlands
J Pathol 178:462-8. 1996Increased mRNA and protein expression of extracellular matrix (ECM) components, including fibronectin, occurs during the development of glomerulonephritis and glomerulosclerosis in immunologically mediated kidney diseases...
- DNA hypomethylation can activate Xist expression and silence X-linked genesB Panning
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Genes Dev 10:1991-2002. 1996....
- ROLE OF FIBRONECTIN IN AIRWAY REMODELING IN ASTHMADENISE HOCKING; Fiscal Year: 2002..the architecture of the airway wall undergoes prominent structural changes, including increased deposition of fibronectin and collagen into the subepithelial region of the airway wall...
- FIBRONECTIN DEPOSITION AND PULMONARY FIBROSISDENISE HOCKING; Fiscal Year: 2002..by fibroblast proliferation and excessive accumulation of extracellular matrix proteins, including fibronectin and types I and III collagen...
- Extracellular Matrix Remodeling and Tissue MechanicsDENISE HOCKING; Fiscal Year: 2004..Our data indicate that the polymerization of fibronectin into the extracellular matrix plays a unique role in regulating both cytoskeletal tension generation and ..
- Mechanisms of Tissue Remodeling By UltrasoundDENISE HOCKING; Fiscal Year: 2004..on biochemically characterizing the effects of ultrasound on the deposition and structural organization of fibronectin and collagen I fibrils in the extracellular matrix...
- Ultrasound Technologies for Tissue EngineeringDENISE C contact HOCKING; Fiscal Year: 2010..End of Abstract) ..
- FN FAK SIGNALING AXIS AND TUMORIGENESISDusko Ilic; Fiscal Year: 2004..rather than formation, and that FAK deficiency in mice results in a phenotype remarkably similar to that of fibronectin (FN) deficiency. In the Damsky lab Dr...
- Cardiac Teratogenicity of LithiumKersti Linask; Fiscal Year: 2004..Until the safety of lithium is conclusively proven, one must assume teratogenic potential and harm to the fetus. ..
- THE ROLE OF SRF IN CARDIAC FUNCTION AND DEVELOPMENTRAVINDRA MISRA; Fiscal Year: 2005..These studies will both elucidate the mechanisms by which SRF functions in heart and will establish powerful new methodologies for studying heart formation and function. ..
- Transcriptional Control of Early Coronary Vascular DevelopmentRAVINDRA P MISRA; Fiscal Year: 2010....