Foxa2

Summary

Gene Symbol: Foxa2
Description: forkhead box A2
Alias: HNF3-beta, HNF3beta, Hnf-3b, Hnf3b, Tcf-3b, Tcf3b, hepatocyte nuclear factor 3-beta, HNF-3-beta, forkhead box protein A2, hepatocyte nuclear factor 3 beta (winged helix transcription factor)
Species: mouse

Top Publications

  1. pmc THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia
    Pamela V Tran
    Genetics Division, Brigham and Women s Hospital, Harvard Medical School, New Research Building, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Genet 40:403-10. 2008
  2. ncbi Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway
    J T Eggenschwiler
    Molecular Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Nature 412:194-8. 2001
  3. ncbi Cerberus-like is a secreted factor with neutralizing activity expressed in the anterior primitive endoderm of the mouse gastrula
    J A Belo
    Department of Biological Chemistry, Howard Hughes Medical Institute, University of California, Los Angeles 90095 1662, USA
    Mech Dev 68:45-57. 1997
  4. ncbi Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis
    Huajing Wan
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 280:13809-16. 2005
  5. ncbi Ftm is a novel basal body protein of cilia involved in Shh signalling
    Jeanette Vierkotten
    Institut für Entwicklungs und Molekularbiologie der Tiere EMT, Heinrich Heine Universitat, 40225 Dusseldorf, Germany
    Development 134:2569-77. 2007
  6. pmc Multiple roles of beta-catenin in controlling the neurogenic niche for midbrain dopamine neurons
    Mianzhi Tang
    VA Medical Center and Department of Pathology, University of California San Francisco, San Francisco, CA 94121, USA
    Development 136:2027-38. 2009
  7. doi A molecular program for contralateral trajectory: Rig-1 control by LIM homeodomain transcription factors
    Sara I Wilson
    Department of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032, USA
    Neuron 59:413-24. 2008
  8. ncbi Live imaging and genetic analysis of mouse notochord formation reveals regional morphogenetic mechanisms
    Yojiro Yamanaka
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, Toronto, Ontario M5G 1X8, Canada
    Dev Cell 13:884-96. 2007
  9. pmc The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age
    Raja Kittappa
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Biol 5:e325. 2007
  10. ncbi The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium
    Joel Weidenfeld
    Department of Medicine, Molecular Cardiology Research Center, and the Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:21061-70. 2002

Research Grants

Scientific Experts

Detail Information

Publications165 found, 100 shown here

  1. pmc THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia
    Pamela V Tran
    Genetics Division, Brigham and Women s Hospital, Harvard Medical School, New Research Building, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Genet 40:403-10. 2008
    ..Specifically, the aln mutation uncouples the roles of anterograde and retrograde transport in SHH signaling, suggesting that anterograde IFT is required for GLI activation and that retrograde IFT modulates this event...
  2. ncbi Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway
    J T Eggenschwiler
    Molecular Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Nature 412:194-8. 2001
    ..The data indicate that dorsalizing signals activate transcription of Rab23 in order to silence the Shh pathway in dorsal neural cells...
  3. ncbi Cerberus-like is a secreted factor with neutralizing activity expressed in the anterior primitive endoderm of the mouse gastrula
    J A Belo
    Department of Biological Chemistry, Howard Hughes Medical Institute, University of California, Los Angeles 90095 1662, USA
    Mech Dev 68:45-57. 1997
    ..A model of how head and trunk development might be regulated is discussed. Given its neuralizing activity, the secreted protein Cer-l is a candidate for mediating inductive activities of anterior visceral endoderm...
  4. ncbi Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis
    Huajing Wan
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 280:13809-16. 2005
    Foxa1 and Foxa2 are closely related family members of the Foxa group of transcription factors that are coexpressed in subsets of respiratory epithelial cells throughout lung morphogenesis...
  5. ncbi Ftm is a novel basal body protein of cilia involved in Shh signalling
    Jeanette Vierkotten
    Institut für Entwicklungs und Molekularbiologie der Tiere EMT, Heinrich Heine Universitat, 40225 Dusseldorf, Germany
    Development 134:2569-77. 2007
    ..Furthermore, the absence of Ftm in arthropods underlines the divergence between vertebrate and Drosophila Hh pathways...
  6. pmc Multiple roles of beta-catenin in controlling the neurogenic niche for midbrain dopamine neurons
    Mianzhi Tang
    VA Medical Center and Department of Pathology, University of California San Francisco, San Francisco, CA 94121, USA
    Development 136:2027-38. 2009
    ..They also suggest that beta-catenin-mediated signaling pathways can be targeted to promote and expand DA neurons in cell-based therapeutic strategies...
  7. doi A molecular program for contralateral trajectory: Rig-1 control by LIM homeodomain transcription factors
    Sara I Wilson
    Department of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032, USA
    Neuron 59:413-24. 2008
    ..Our findings reveal a link between the transcriptional programs that define neuronal subtype identity and the expression of receptors that guide distinctive aspects of their trajectory...
  8. ncbi Live imaging and genetic analysis of mouse notochord formation reveals regional morphogenetic mechanisms
    Yojiro Yamanaka
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, Toronto, Ontario M5G 1X8, Canada
    Dev Cell 13:884-96. 2007
    ..We also reveal distinct genetic regulation within these different regions. We show that Foxa2 compensates for and genetically interacts with Noto in the trunk notochord, and that Noto has an evolutionarily ..
  9. pmc The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age
    Raja Kittappa
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Biol 5:e325. 2007
    ..The forkhead transcription factor, foxa2, is specifically expressed in adult dopamine neurons and their precursors in the medial floor plate...
  10. ncbi The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium
    Joel Weidenfeld
    Department of Medicine, Molecular Cardiology Research Center, and the Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:21061-70. 2002
    ..contains several DNA binding sites for the important lung-restricted transcription factors TTF-1, GATA6, and Foxa2. Electrophoretic mobility shift assays showed that TTF-1, GATA6, and Foxa2 can bind to a specific subset of their ..
  11. pmc Cilia and Hedgehog responsiveness in the mouse
    Danwei Huangfu
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:11325-30. 2005
    ....
  12. ncbi Foxa2 integrates the transcriptional response of the hepatocyte to fasting
    Liping Zhang
    Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cell Metab 2:141-8. 2005
    ..Here we show using cell-type-specific gene ablation that the winged helix transcription factor Foxa2 is required for activation of the hepatic gluconeogenic program during fasting...
  13. pmc Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress
    Irina M Bochkis
    Department of Genetics and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    Nat Med 14:828-36. 2008
    ..location analysis ('ChIP-on-chip') and cell type-specific gene ablation that the winged helix transcription factor Foxa2 is required for normal bile acid homeostasis...
  14. ncbi Foxa2 is required for the differentiation of pancreatic alpha-cells
    Catherine S Lee
    Department of Genetics and Penn Diabetes Center, University of Pennsylvania School of Medicine, 415 Curie Boulevard, CRB 560 Philadelphia, PA 19104, USA
    Dev Biol 278:484-95. 2005
    ..Here we utilize a novel YAC-based Foxa3Cre transgene to delete the winged helix transcription factor Foxa2 (formerly HNF-3beta) in the pancreatic primordium during midgestation...
  15. pmc Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas
    Aiping Du
    Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Diabetes 58:2059-69. 2009
    ....
  16. doi Foxa1 and Foxa2 positively and negatively regulate Shh signalling to specify ventral midbrain progenitor identity
    Yannis E Mavromatakis
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Mech Dev 128:90-103. 2011
    b>Foxa2, a member of the Foxa family of forkhead/winged helix family of transcription factors, has previously been shown to be an upstream positive regulator of Shh expression in many different tissues...
  17. pmc GABAergic and glutamatergic identities of developing midbrain Pitx2 neurons
    M R Waite
    Cellular and Molecular Biology Program, The University of Michigan, Ann Arbor, Michigan, USA
    Dev Dyn 240:333-46. 2011
    ..Our data suggest that PITX2 is present in regionally restricted subpopulations of midbrain neurons and may have unique functions that promote GABAergic and glutamatergic differentiation...
  18. ncbi Thyroid transcription factor-1, hepatocyte nuclear factor-3beta, surfactant protein B, C, and Clara cell secretory protein in developing mouse lung
    L Zhou
    Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229 3039, USA
    J Histochem Cytochem 44:1183-93. 1996
    ..The early expression of TTF-1 and HNF-3beta, preceding and overlapping that of pro-SP-B, mature SP-B, pro-SP-C, and CCSP, supports a regulatory role for TTF-1 and HNF-3beta in lung-specific gene expression...
  19. pmc Global analysis of in vivo Foxa2-binding sites in mouse adult liver using massively parallel sequencing
    Elizabeth D Wederell
    Terry Fox Laboratory, BC Cancer Agency, Vancouver, Canada
    Nucleic Acids Res 36:4549-64. 2008
    Foxa2 (HNF3 beta) is a one of three, closely related transcription factors that are critical to the development and function of the mouse liver...
  20. doi Mouse Shh is required for prechordal plate maintenance during brain and craniofacial morphogenesis
    Kazushi Aoto
    Molecular Neuropathology Group, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Dev Biol 327:106-20. 2009
    ..These findings provide new insight into the mechanism underlying HPE pathoetiology during dynamic brain and craniofacial morphogenesis...
  21. ncbi The HNF-3 gene family of transcription factors in mice: gene structure, cDNA sequence, and mRNA distribution
    K H Kaestner
    Division of Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg
    Genomics 20:377-85. 1994
    ..Transcripts for HNF-3 beta and alpha are detected most abundantly in midgestation embryos (Day 9.5), while HNF-3 gamma expression peaks around Day 15.5 of gestation...
  22. pmc Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation
    Shannon E Powers
    Department of Biochemistry and Molecular Genetics, and Center for Cell Signaling, University of Virginia, Box 800577, HSC, Charlottesville VA 22908, USA
    Development 137:249-59. 2010
    ..Together, these data show that Tgif function is required for gastrulation, and provide the first clear evidence that Tgifs limit the transcriptional response to Nodal signaling during early embryogenesis...
  23. ncbi Requirement for Lim1 in head-organizer function
    W Shawlot
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Nature 374:425-30. 1995
    ..A partial secondary axis developed anteriorly in some mutant embryos. Lim1 is thus an essential regulator of the vertebrate head organizer...
  24. ncbi A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain
    S L Ang
    Institute de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, Illkirch, C U de Strasbourg, France
    Development 122:243-52. 1996
    ....
  25. ncbi The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation
    J P Martinez Barbera
    Division of Mammalian Development, National Institute for Medical Research, The Ridgeway, London, NW7 1AA, UK
    Development 127:2433-45. 2000
    ..All together, these results demonstrate that Hex function is essential in definitive endoderm for normal development of the forebrain, liver and thyroid gland...
  26. ncbi The orphan steroid receptor Nur77 family member Nor-1 is essential for early mouse embryogenesis
    R Andrea DeYoung
    Department of Molecular and Cell Biology, Division of Immunology, University of California at Berkeley, Berkeley, CA 94720 3200, USA
    J Biol Chem 278:47104-9. 2003
    ..Abnormal expression of a number of early developmental markers and defects in growth or distribution of emerging mesoderm cells were also detected. These data suggest that Nor-1 plays a crucial role in gastrulation...
  27. pmc Genome-wide relationship between histone H3 lysine 4 mono- and tri-methylation and transcription factor binding
    A Gordon Robertson
    BC Cancer Agency Genome Sciences Centre, Vancouver, Canada
    Genome Res 18:1906-17. 2008
    ..factors: STAT1 in the immortalized HeLa S3 cell line, with and without interferon-gamma (IFNG) stimulation; and FOXA2 in mouse adult liver tissue...
  28. pmc Transcriptional dynamics of endodermal organ formation
    Richard I Sherwood
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Dev Dyn 238:29-42. 2009
    ..These results contribute to understanding the mechanism of endodermal organogenesis and should assist efforts to replicate this process using pluripotent stem cells...
  29. pmc Wnt signaling maintains the notochord fate for progenitor cells and supports the posterior extension of the notochord
    Kanako Ukita
    Laboratory for Embryonic Induction, RIKEN Center for Developmental Biology, Chuo, Kobe, Hyogo 650 0047, Japan
    Mech Dev 126:791-803. 2009
    ..Taken together, our data indicate that the NPCs are derived from Noto-positive node cells, and are not fully committed to a notochordal fate. Sustained Wnt signaling is required to maintain the NPCs' notochordal fate...
  30. pmc Interactions of Wnt/beta-catenin signaling and sonic hedgehog regulate the neurogenesis of ventral midbrain dopamine neurons
    Mianzhi Tang
    Department of Pathology, University of California, San Francisco and Pathology Service, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Neurosci 30:9280-91. 2010
    ..Persistent activation of beta-catenin in early progenitors perturbs their cell cycle progression and antagonizes Shh expression, whereas activation of beta-catenin in midline progenitors promotes the generation of dopamine neurons...
  31. pmc Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development
    Nan Gao
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Genes Dev 22:3435-48. 2008
    ..We demonstrate here that the winged-helix transcription factors Foxa1 and Foxa2 co-occupy multiple regulatory domains in the Pdx1 gene...
  32. pmc Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain
    John Jacob
    MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 136:2477-85. 2009
    ..Thus, Insm1 regulates the synthesis of distinct monoaminergic neurotransmitters by acting combinatorially with, or independently of, Ascl1 in specific monoaminergic populations...
  33. pmc Foxa2 regulates multiple pathways of insulin secretion
    Kristen A Lantz
    Department of Genetics, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    J Clin Invest 114:512-20. 2004
    ..first mouse model for PHHI has a conditional deletion of the gene encoding the winged-helix transcription factor Foxa2 (Forkhead box a2, formerly Hepatocyte nuclear factor 3beta) in pancreatic beta cells...
  34. ncbi Zic2 and Zic3 synergistically control neurulation and segmentation of paraxial mesoderm in mouse embryo
    Takashi Inoue
    Laboratory for Comparative Neurogenesis, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
    Dev Biol 306:669-84. 2007
    ....
  35. doi Identification of midbrain floor plate radial glia-like cells as dopaminergic progenitors
    Sonia Bonilla
    Laboratory of Molecular Neurobiology, MBB, Karolinska Institutet, Scheeles vag 1, A1 2, 171 77 Stockholm, Sweden
    Glia 56:809-20. 2008
    ..Combined, our experiments support the concept that the midbrain FP differs from other FP regions and demonstrate that FP radial glia-like cells in the midbrain are neurogenic and give rise to midbrain DA neurons...
  36. doi Lmx1a and Lmx1b cooperate with Foxa2 to coordinate the specification of dopaminergic neurons and control of floor plate cell differentiation in the developing mesencephalon
    Tomoya Nakatani
    KAN Research Institute Inc, Kobe MI R and D Center, 6 7 3 Minatojima minamimachi, Chuo Ku, Kobe, Hyogo 650 0047, Japan
    Dev Biol 339:101-13. 2010
    ..In the present study, we obtained evidence that Lmx1a and Lmx1b cooperate with Foxa2 to specify mesDA neuron identity by gain-of-function approaches using transgenic mice...
  37. pmc Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia
    N J Sund
    Department of Genetics, Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 15:1706-15. 2001
    ..conditional gene ablation to uncover a dramatic and unpredicted role for the winged-helix transcription factor Foxa2 (formerly HNF-3 beta) in pancreatic beta-cell differentiation and metabolism...
  38. ncbi Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning
    Steven A Vokes
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 134:1977-89. 2007
    ..Together, these approaches provide significant new insights into both tissue-specific and general transcriptional targets in a crucial Shh-mediated patterning process...
  39. ncbi The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo
    D C Weinstein
    Laboratory of Molecular Cell Biology, Rockefeller University, New York, New York 10021
    Cell 78:575-88. 1994
    ..Endodermal cells are present but fail to form a gut tube in mutant embryos. These studies indicate that HNF-3 beta has an essential role in the development of axial mesoderm in mouse embryos...
  40. ncbi The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice
    U Ahlgren
    Department of Microbiology, University of Umea, Sweden
    Development 122:1409-16. 1996
    ..Together these data provide evidence that PDX-1 acts cell autonomously and that the lack of a pancreas in the pdx1-/- mice is due to a defect in the pancreatic epithelium...
  41. ncbi Open brain, a new mouse mutant with severe neural tube defects, shows altered gene expression patterns in the developing spinal cord
    T Gunther
    Max Planck Institut für Immunobiologie, Freiburg, Germany
    Development 120:3119-30. 1994
    ..The implications of these findings are discussed in the context of dorsoventral patterning of the developing neural tube and compared with known mouse mutants exhibiting similar defects...
  42. ncbi HNF-3 beta as a regulator of floor plate development
    H Sasaki
    Howard Hughes Medical Institute, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2175
    Cell 76:103-15. 1994
    ..Ectopic dorsal neuronal differentiation and abnormal dorsal axonal projections are also seen. These results suggest that HNF-3 beta is an important regulator of floor plate development in vivo...
  43. ncbi Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway
    D J Epstein
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Development 122:2885-94. 1996
    ..As both of these are targets of Drosophila Hh signaling, our data point to an evolutionary conservation in both the mechanisms of signaling and the effectors of the signaling pathway...
  44. ncbi Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli-1
    M Hynes
    Department of Neuroscience, Genentech, Inc, South San Francisco, California 94080, USA
    Neuron 19:15-26. 1997
    ..These findings demonstrate that GLI-1 can reproduce the cell patterning actions of Shh in the developing nervous system and provide support for the hypothesis that it is a mediator of the Shh signal in vertebrates...
  45. pmc Hepatocyte nuclear factor 3beta is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene
    K L Wu
    Department of Molecular Physiology and Biophysics, Vanderbilt Medical Center, Nashville, Tennessee 37232, USA
    Mol Cell Biol 17:6002-13. 1997
    ..Gel shift analysis indicated that HNF3beta present in islet beta cells binds to this element...
  46. pmc Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta
    David Q Shih
    Laboratory of Metabolic Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 99:3818-23. 2002
    ..These studies also established polygenic mouse models for investigating the mechanisms contributing to beta-cell dysfunction in diabetes...
  47. pmc A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord
    Mark Wijgerde
    Department of Molecular and Cellular Biology, The Biolabs, Harvard University, Cambridge, Massachusetts 02138, USA
    Genes Dev 16:2849-64. 2002
    ..Thus, Hh signaling is essential for organizing ventral cell pattern, possibly through the control of differential cell affinities...
  48. pmc Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity
    Madelen Persson
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, S 171 77 Stockholm, Sweden
    Genes Dev 16:2865-78. 2002
    ..Together these data raise the possibility that Gli proteins act as common mediators integrating Shh signals, and other sources of positional information, to control patterning throughout the ventral neural tube...
  49. ncbi Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain
    Eduardo Puelles
    MRC Centre for Developmental Neurobiology, New Hunt s House, 4th Floor, King s College London, Guy s Campus, London Bridge, London SE1 1UL, UK
    Nat Neurosci 6:453-60. 2003
    ..We propose that this mechanism may provide both A-P and D-V positional information to neuronal precursors located within the midbrain...
  50. ncbi Conserved transcriptional regulatory domains of the pdx-1 gene
    Kevin Gerrish
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, 723 Light Hall, Nashville, Tennessee 37215, USA
    Mol Endocrinol 18:533-48. 2004
    ..This newly recognized conserved subdomain has been termed area IV. The islet-enriched forkhead box A2 (FoxA2), NK2 homeobox 2.2 (Nkx2...
  51. ncbi Multiple roles for Nodal in the epiblast of the mouse embryo in the establishment of anterior-posterior patterning
    Cindy C Lu
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Dev Biol 273:149-59. 2004
    ....
  52. pmc Foxa2 is required for transition to air breathing at birth
    Huajing Wan
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Proc Natl Acad Sci U S A 101:14449-54. 2004
    ..Here we demonstrate that expression of the forkhead gene Foxa2 in respiratory epithelial cells of the peripheral lung controls pulmonary maturation at birth...
  53. ncbi A hepatocyte nuclear factor-3 site in the fibrinogen beta promoter is important for interleukin 6-induced expression, and its activity is influenced by the adjacent -148C/T polymorphism
    Maartje Verschuur
    Hemostasis and Thrombosis Research Center, Department of Hematology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, Gaubius Laboratory, TNO Quality of Life, P O Box 2215, 2301 CE Leiden, The Netherlands
    J Biol Chem 280:16763-71. 2005
    ....
  54. ncbi The initiation of liver development is dependent on Foxa transcription factors
    Catherine S Lee
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nature 435:944-7. 2005
    ..Here we show that Foxa1 and Foxa2 (forkhead box proteins A1 and A2) are required in concert for hepatic specification in mouse...
  55. pmc Transcriptional networks in the liver: hepatocyte nuclear factor 6 function is largely independent of Foxa2
    Nir E Rubins
    Department of Genetics, University of Pennsylvania, Philadelphia, 19104, USA
    Mol Cell Biol 25:7069-77. 2005
    A complex network of hepatocyte nuclear transcription factors, including HNF6 and Foxa2, regulates the expression of liver-specific genes. The current model, based on in vitro studies, suggests that HNF6 and Foxa2 interact physically...
  56. ncbi Mouse Rab23 regulates hedgehog signaling from smoothened to Gli proteins
    Jonathan T Eggenschwiler
    Developmental Biology Program, Sloan Kettering Institute, New York, NY 10021, USA
    Dev Biol 290:1-12. 2006
    ..Instead, Rab23 appears to regulate subcellular localization of essential components of the Hedgehog pathway that act downstream of Smoothened and upstream of Gli proteins...
  57. ncbi Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway
    Jessica Svärd
    Department of Biosciences at Novum, Karolinska Institutet, SE 141 57 Huddinge, Sweden
    Dev Cell 10:187-97. 2006
    ..Our data demonstrate that, in striking contrast to Drosophila, in mammals, Sufu has a central role, and its loss of function leads to potent ligand-independent activation of the Hh pathway...
  58. pmc Hippi is essential for node cilia assembly and Sonic hedgehog signaling
    Caroline Houde
    Biochemistry Department, McGill University, Montreal, Canada H3G 1Y6
    Dev Biol 300:523-33. 2006
    ....
  59. ncbi Mouse Fkbp8 activity is required to inhibit cell death and establish dorso-ventral patterning in the posterior neural tube
    Rebecca Lee Yean Wong
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, The Texas A and M University System Health Science Center, 2121 W Holcombe Blvd, Houston, TX 77030, USA
    Hum Mol Genet 17:587-601. 2008
    ..The mutant Fkbp8 allele is a new experimental model which will be useful in dissecting the pathogenesis of spinal NTDs, and enhance our understanding of the etiology of human NTDs...
  60. ncbi Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head
    E Lai
    Division of Endocrinology, Memorial Sloan Kettering Cancer Center, New York, New York 10021
    Genes Dev 5:416-27. 1991
    ....
  61. ncbi Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse
    G Winnier
    Howard Hughes Medical Institute, Vanderbilt University Medical School, Nashville, Tennessee 37232 2175, USA
    Genes Dev 9:2105-16. 1995
    ..Moreover, in the presumed absence of zygotic ligand, it appears that homozygous mutants can be rescued partially by related proteins or by maternal BMP-4...
  62. ncbi Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity
    Y Echelard
    Harvard University, Department of Biochemistry, Molecular Biology, and Cellular and Developmental Biology, Cambridge, Massachusetts 02138
    Cell 75:1417-30. 1993
    ..Ectopic expression of Shh in the mouse CNS leads to the activation of floor plate-expressed genes. These results suggest that Shh may play a role in the normal inductive interactions that pattern the ventral CNS...
  63. ncbi HNF-3 beta is essential for node and notochord formation in mouse development
    S L Ang
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Cell 78:561-74. 1994
    ..HNF-3 beta is not required for the development of definitive endoderm cells, but foregut morphogenesis is severely affected in HNF-3 beta -/- embryos...
  64. ncbi Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 alpha, beta and gamma genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm
    A P Monaghan
    Division Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg
    Development 119:567-78. 1993
    ..We also conclude that HNF-3 beta is the true orthologue of the Drosophila forkhead gene...
  65. ncbi The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins
    S L Ang
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    Development 119:1301-15. 1993
    ..We recovered mouse HNF3 beta from an embryo cDNA library and found that the gene is first expressed in the anterior portion of the primitive ..
  66. ncbi Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo
    H Sasaki
    Department of Cell Biology, Vanderbilt University Medical School, Nashville, Tennessee 37232
    Development 118:47-59. 1993
    ..A model is proposed linking FD gene expression with gastrulation events in the mouse...
  67. ncbi Relationship between asymmetric nodal expression and the direction of embryonic turning
    J Collignon
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 381:155-8. 1996
    ..Taken together, these experiments, along with similar findings in chick, demonstrate that elements of the genetic pathway that establish the left-right body axis are conserved in vertebrates...
  68. ncbi Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
    C Chiang
    Laboratory of Mammalian Genes and Development, National Institute of Health, Bethesda, Maryland 20892, USA
    Nature 383:407-13. 1996
    ..Defects in all tissues extend beyond the normal sites of Shh transcription, confirming the proposed role of Shh proteins as an extracellular signal required for the tissue-organizing properties of several vertebrate patterning centres...
  69. ncbi Altered neural cell fates and medulloblastoma in mouse patched mutants
    L V Goodrich
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5427, USA
    Science 277:1109-13. 1997
    ..Mice heterozygous for the ptc mutation were larger than normal, and a subset of them developed hindlimb defects or cerebellar medulloblastomas, abnormalities also seen in BCNS patients...
  70. ncbi Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice
    Q Ding
    Program in Developmental Biology and Division of Endocrinology, Research Institute, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Development 125:2533-43. 1998
    ..Our results imply that Gli2 is required to mediate high level but not low level Shh activity and show that the development of motor neurons can occur in the absence of floor plate induction...
  71. ncbi Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system
    M P Matise
    Developmental Genetics Program and Howard Hughes Medical Institute, and Department of Cell Biology and Physiology and Neuroscience, NYU Medical Center, New York, NY 10016, USA
    Development 125:2759-70. 1998
    ....
  72. ncbi Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling
    J Briscoe
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Nature 398:622-7. 1999
    ..Thus, Nkx2.2 has an essential role in interpreting graded Shh signals and selecting neuronal identity...
  73. ncbi Isolation of novel cDNAs by subtractions between the anterior mesendoderm of single mouse gastrula stage embryos
    A Shimono
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas, 77030, USA
    Dev Biol 209:369-80. 1999
    ..Furthermore, this differential screen strategy should provide a broadly applicable approach to identify differences in gene expression between embryonic tissues of limiting quantity...
  74. ncbi Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling
    H Sasaki
    Laboratory of Developmental Biology, Institute for Molecular and Cellular Biology, Osaka University, Suita, Osaka 565 0871, Japan
    Development 126:3915-24. 1999
    ..mouse embryos, N-terminally truncated Gli2, unlike the full length protein, activates a Shh target gene, HNF3beta, in the dorsal neural tube, thus mimicking the effect of Shh signal...
  75. ncbi The organizer factors Chordin and Noggin are required for mouse forebrain development
    D Bachiller
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles 90095 1662, USA
    Nature 403:658-61. 2000
    ..The results show that BMP antagonists in the node and its derivatives are required for head development...
  76. ncbi The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determination
    N S Murcia
    Department of Pediatrics, Rainbow Babies and Children s Hospital, Case Western Reserve University, Cleveland, OH 44106, USA
    Development 127:2347-55. 2000
    ..We have named the product of the Tg737 gene Polaris, which is based on the various polarity related defects associated with the different alleles of the Tg737 gene...
  77. pmc Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte
    N J Sund
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6145, USA
    Mol Cell Biol 20:5175-83. 2000
    ..One of these, the winged helix transcription factor hepatocyte nuclear factor 3beta (HNF3beta or Foxa2) is essential for multiple stages of embryonic development...
  78. ncbi Transcriptional regulation of liver development
    S A Duncan
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Dev Dyn 219:131-42. 2000
    ..The picture that emerges is that specific transcription factors use novel mechanisms to orchestrate changes in gene expression patterns that ultimately direct cell differentiation...
  79. ncbi Dorsal and lateral fates in the mouse neural tube require the cell-autonomous activity of the open brain gene
    J T Eggenschwiler
    Molecular Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
    Dev Biol 227:648-60. 2000
    ..The data indicate that opb(+) could act as either a novel component of a dorsalizing pathway or a novel intracellular negative regulator of the Shh signal transduction pathway...
  80. ncbi Nodal signalling in the epiblast patterns the early mouse embryo
    J Brennan
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nature 411:965-9. 2001
    ..Our experiments show that proximal-distal and subsequent anterior-posterior polarity of the pregastrulation embryo result from reciprocal cell-cell interactions between the epiblast and the two extra-embryonic tissues...
  81. ncbi The organizer of the mouse gastrula is composed of a dynamic population of progenitor cells for the axial mesoderm
    S J Kinder
    Embryology Unit, Children s Medical Research Institute, Locked Bag 23, Wentworthville, NSW 2145, Australia
    Development 128:3623-34. 2001
    ..been identified in the anterior end of the primitive streak of the mid-streak stage embryo, by the expression of Hnf3beta, Gsc(lacZ) and Chrd, and the ability of these cells to induce a second neural axis in the host embryo...
  82. ncbi Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis
    A Bhushan
    INSERM 457, Hospital Robert Debre, 75019 Paris, France
    Development 128:5109-17. 2001
    ..These results indicate that Fgf10 signalling is required for the normal development of the pancreas and should prove useful in devising methods to expand pancreatic progenitor cells...
  83. ncbi Protein kinase A deficiency causes axially localized neural tube defects in mice
    Yongzhao Huang
    Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Biol Chem 277:19889-96. 2002
    ..The regional sensitivity to changes in PKA activity indicates that downstream signaling pathways differ along the anterior-posterior axis and suggests a functional role for PKA activation in neural tube development...
  84. ncbi Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway
    C Brian Bai
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Development 129:4753-61. 2002
    ..Our studies demonstrate that, in mammals, Gli1 is not required for Shh signaling and that Gli2 mediates inappropriate activation of the pathway due to loss of the negative regulator Ptc...
  85. ncbi The Onecut transcription factor HNF-6 (OC-1) is required for timely specification of the pancreas and acts upstream of Pdx-1 in the specification cascade
    Patrick Jacquemin
    Hormone and Metabolic Research Unit, Université catholique de Louvain and Institute of Cellular Pathology, Avenue Hippocrate 75, B 1200 Brussels, Belgium
    Dev Biol 258:105-16. 2003
    ..Together with the known role of HNF-6 in pancreatic endocrine cell differentiation, our data point to HNF-6 as a key regulator of pancreas development...
  86. ncbi Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification
    Jun Motoyama
    Molecular Neuropathology Group, Brain Research Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Dev Biol 259:150-61. 2003
    ..Thus, Shh signaling is mediated by overlapping but distinct functions of Gli2 and Gli3, and their relative contributions vary along the rostral-caudal axis...
  87. ncbi Distinct regulators of Shh transcription in the floor plate and notochord indicate separate origins for these tissues in the mouse node
    Yongsu Jeong
    Department of Genetics, University of Pennsylvania School of Medicine, Clinical Research Building, Room 470, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Development 130:3891-902. 2003
    ..X-gal-positive cells emerging from the node were only detected in the notochord lineage, suggesting that the floor plate and notochord arise from distinct precursors in the mouse node...
  88. ncbi Hedgehog signalling in the mouse requires intraflagellar transport proteins
    Danwei Huangfu
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
    Nature 426:83-7. 2003
    ..Our data show that IFT machinery has an essential and vertebrate-specific role in Hedgehog signal transduction...
  89. ncbi Foxa2 regulates alveolarization and goblet cell hyperplasia
    Huajing Wan
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Development 131:953-64. 2004
    ..The winged helix transcription factor, FOXA2, is expressed in the foregut endoderm and in subsets of respiratory epithelial cells in the fetal and adult lung...
  90. ncbi FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues
    Oleg V Bulgakov
    The Berman Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Development 131:2149-59. 2004
    ..Although it is expressed broadly, FKBP8 is required to antagonize SHH signaling primarily in neural tissues, suggesting that hedgehog signal transduction is subject to cell-type specific modulation during mammalian development...
  91. ncbi The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice
    Olivia G Kelly
    Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720 3200, USA
    Development 131:2803-15. 2004
    ..The effect of reducing, but not eliminating, Wnt signaling in Lrp5(+/-);Lrp6(-/-) mutant embryos provides important insight into the interplay between Wnt, Fgf and Nodal signals in patterning the early mouse embryo...
  92. pmc The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation
    Hanaa Ben Abdelkhalek
    Institute for Molecular Biology OE5250, Medizinische Hochschule Hannover, D 30625 Hannover, Germany
    Genes Dev 18:1725-36. 2004
    ..Not expression is abolished in Foxa2 and T mutant embryos, suggesting that Not acts downstream of both genes during notochord development...
  93. ncbi Immunohistochemical localization of Foxa1 and Foxa2 in mouse embryos and adult tissues
    Valérie Besnard
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Gene Expr Patterns 5:193-208. 2004
    Members of the Forkhead box (Fox) transcription factors family Foxa1 (Hnf-3 alpha), Foxa2 (Hnf-3 beta) are known to influence gene expression in endodermally derived tissues including lung, liver, pancreas, stomach, and intestine...
  94. ncbi Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1
    Juhee Jeong
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Development 132:143-54. 2005
    ..Furthermore, this feedback mechanism is crucial in generating a neural tube that contains appropriate numbers of all ventral and intermediate neuronal cell types...
  95. ncbi Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex
    Noriyuki Nishioka
    Laboratory for Embryonic Induction, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe, Hyogo 650 0047, Japan
    Development 132:2535-46. 2005
    ..These results suggest that Ssdp1 regulates the development of late head organizer tissues and body growth by functioning as an essential activator component of a Lim1 complex through interaction with Ldb1...
  96. ncbi Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused
    Ayanna F Cooper
    Yale University School of Medicine, Box 208005, New Haven, CT 06520 8005, USA
    Development 132:4407-17. 2005
    ..The resemblance of Sufu homozygotes to Ptch1 homozygotes is consistent with mouse Sufu being a conserved negative modulator of Hh signaling...
  97. ncbi Zic3 is critical for early embryonic patterning during gastrulation
    Stephanie M Ware
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Dev Dyn 235:776-85. 2006
    ..At later stages, deficiency of Zic3 results in abnormal mesoderm allocation. These results indicate a requirement for Zic3 during early embryogenesis prior to cardiac and visceral organ patterning...
  98. ncbi Coactivation of Foxa2 through Pgc-1beta promotes liver fatty acid oxidation and triglyceride/VLDL secretion
    Christian Wolfrum
    Laboratory of Metabolic Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Cell Metab 3:99-110. 2006
    Forkhead transcription factor Foxa2 activates genes involved in hepatic lipid metabolism and is regulated by insulin...
  99. ncbi Synergistic interaction between Gdf1 and Nodal during anterior axis development
    Olov Andersson
    Division of Molecular Neurobiology, Department of Neuroscience, Karolinska Institutet, S 17177 Stockholm, Sweden
    Dev Biol 293:370-81. 2006
    ..This notion was supported by a severe downregulation of FoxA2 and goosecoid in the anterior primitive streak of double mutant embryos...
  100. ncbi Regulation of the mouse protein targeting to glycogen (PTG) promoter by the FoxA2 forkhead protein and by 3',5'-cyclic adenosine 5'-monophosphate in H4IIE hepatoma cells
    Alan Cheng
    Department of Internal Medicine, Life Sciences Institute, University of Michigan, Ann Arbor, 48109, USA
    Endocrinology 147:3606-12. 2006
    ..In this study, we have cloned and characterized the mouse promoter of PTG. We identified multiple FoxA2 binding sites within this region...
  101. ncbi The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice
    Toyoaki Tenzen
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Dev Cell 10:647-56. 2006
    ..Cdo and Boc bind Shh through a high-affinity interaction with a specific fibronectin repeat that is essential for activity. We propose a model where Cdo and Boc enhance Shh signaling within its target field...

Research Grants14

  1. PIONEER AXON GUIDANCE IN THE EMBRYONIC FOREBRAIN
    GRANT MASTICK; Fiscal Year: 2004
    ..In addition, the mechanisms of axon growth during development may give insight into how regeneration of the nervous system may be stimulated following trauma or disease. ..
  2. Regulation of Key Processes in Oocyte Biology
    Martin Matzuk; Fiscal Year: 2007
    ..Compromised fertility in knockout models lacking these oocyte-specific genes would demonstrate that these proteins are potential contraceptive targets and possibly mutated in infertile women. ..
  3. Interactive Mediators of Injury & Development
    Parviz Minoo; Fiscal Year: 2008
    ..1. ..
  4. Longitudinal axon guidance by long range cues in the embryonic brain
    GRANT STEPHEN MASTICK; Fiscal Year: 2011
    ....
  5. MOUSE MODELS TO STUDY GONADAL TUMOR DEVELOPMENT
    Martin M Matzuk; Fiscal Year: 2010
    ..Characterization of these mice will lead to important insights into the development of gonadal cancers in men and women and the roles of several proteins in reproductive physiology. ..
  6. Defining the Mammalian Intercellular Bridge Interactome
    Martin M Matzuk; Fiscal Year: 2010
    ..Our proposed Specific Aims will also help us to develop additional high throughput screening assays for the identification of small molecule disruptors of the intercellular bridge. ..
  7. GLUCOKINASE GENE EXPRESSION IN PANCREATIC BETA CELL
    Mark Magnuson; Fiscal Year: 2005
    ..In Aim 3 we will determine the role of alternate RNA processing the insulin receptor in modulating both GK gene transcription and subcellular localization in the pancreatic beta cell. ..
  8. Expression profiling of human islets
    KLAUS KAESTNER; Fiscal Year: 2006
    ....
  9. FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATION
    KLAUS KAESTNER; Fiscal Year: 2003
    ....
  10. INVESTIGATING THE ROLE OF CDO IN BRAIN DEVELOPMENT
    Ami Okada; Fiscal Year: 2004
    ..These experiments should also contribute to the overall understanding of the signals that are important in the assembly of the nervous system. ..
  11. Zic3 and the Control of Body Pattern Formation
    STEPHANIE WARE; Fiscal Year: 2005
    ..Through a combination of supervised research, scientific interchange, and selected coursework within this environment, the candidate will obtain the training necessary to transition to an independent investigator. ..
  12. Development of C57BL/6 ES cell technology for high thoughput use.
    KLAUS KAESTNER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  13. FUNCTIONAL GENOMICS OF THE BETA-CELL
    KLAUS KAESTNER; Fiscal Year: 2007
    ..The new resources generated through this project will be made available to the NIDDK-funded biotechnology centers and the diabetes research community at large. ..
  14. Liver Biology, Development and Disease
    KLAUS KAESTNER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..