Foxd3

Summary

Gene Symbol: Foxd3
Description: forkhead box D3
Alias: CWH3, Genesis, Hfh2, forkhead box protein D3, HFH-2, HNF-3/forkhead homolog 2, HNF3/FH transcription factor genesis, hepatocyte nuclear factor 3 forkhead homolog 2
Species: mouse

Top Publications

  1. ncbi The winged-helix transcription factor Foxd3 suppresses interneuron differentiation and promotes neural crest cell fate
    M Dottori
    Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Development 128:4127-38. 2001
  2. pmc Mouse models of Hirschsprung disease and other developmental disorders of the enteric nervous system: Old and new players
    Nadege Bondurand
    INSERM, U955, Equipe 6, F 94000 Creteil, France Université Paris Est, UPEC, F 94000 Creteil, France Electronic address
    Dev Biol 417:139-57. 2016
  3. pmc Ground-state transcriptional requirements for skin-derived precursors
    Michael T Suflita
    Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA
    Stem Cells Dev 22:1779-88. 2013
  4. pmc Neural crest and Schwann cell progenitor-derived melanocytes are two spatially segregated populations similarly regulated by Foxd3
    Erez Nitzan
    Department of Medical Neurobiology, IMRIC and ELSC, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Proc Natl Acad Sci U S A 110:12709-14. 2013
  5. pmc Advancements and challenges in generating accurate animal models of gestational diabetes mellitus
    Raymond C Pasek
    Tennessee Valley Healthcare System, Department of Veteran Affairs, Nashville, Tennessee
    Am J Physiol Endocrinol Metab 305:E1327-38. 2013
  6. pmc Grb2 is regulated by foxd3 and has roles in preventing accumulation and aggregation of mutant huntingtin
    Shounak Baksi
    Structural Genomics Division, Saha Institute of Nuclear Physics, Kolkata, India
    PLoS ONE 8:e76792. 2013
  7. pmc Transcriptional targets of Foxd3 in murine ES cells
    Jennifer L Plank
    Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA Center for Stem Cell Biology, Vanderbilt University, Nashville, TN, USA Electronic address
    Stem Cell Res 12:233-40. 2014
  8. pmc Vascular endothelial growth factor coordinates islet innervation via vascular scaffolding
    Rachel B Reinert
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Development 141:1480-91. 2014
  9. doi Homeobox b5 (Hoxb5) regulates the expression of Forkhead box D3 gene (Foxd3) in neural crest
    Mandy Ka Man Kam
    Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China
    Int J Biochem Cell Biol 55:144-52. 2014
  10. pmc Foxd3 suppresses NFAT-mediated differentiation to maintain self-renewal of embryonic stem cells
    Lili Zhu
    Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes of Biological Sciences Chinese Academy of Sciences Shanghai JiaoTong University School of Medicine, Shanghai, China
    EMBO Rep 15:1286-96. 2014

Research Grants

  1. Functional Analysis of Spinal Cord Interneurons
    Martyn Goulding; Fiscal Year: 2005
  2. Specification of Dorsal Lbx1-Derived Interneurons
    Martyn Goulding; Fiscal Year: 2007
  3. Neural crest formation and maintenance of multipotency
    Patricia Labosky; Fiscal Year: 2009

Scientific Experts

  • Nadege Bondurand
  • Jennifer L Plank
  • Martyn D Goulding
  • VESA M KAARTINEN
  • Jr-Kai Yu
  • Patricia Labosky
  • Alfred S L Cheng
  • Nathan A Mundell
  • Erez Nitzan
  • Elise R Pfaltzgraff
  • Thomas Muller
  • Daniel Mesnard
  • Jan Masek
  • Ondrej Machon
  • Carmen Birchmeier
  • Raga Krishnakumar
  • Lu Teng
  • Patricia Respuela
  • Matthew J Anderson
  • Oraly Sanchez-Ferras
  • Zbynek Kozmik
  • Mathias Treier
  • Jun Hai Yan
  • Mark Lewandoski
  • Rachel B Reinert
  • Lili Zhu
  • Mandy Ka Man Kam
  • Raymond C Pasek
  • Anthony D Krentz
  • Shounak Baksi
  • Chaya Kalcheim
  • Desire M Buckley
  • Michael T Suflita
  • Floor J Stam
  • Nadja Makki
  • Igor Adameyko
  • Brian L Nelms
  • Vanessa L Horner
  • Daniel B Constam
  • Catarina Ramos
  • Ashok Mittal
  • Daniel Liber
  • Audrey Y Frist
  • Robert Storm
  • George R Miesegaes
  • Ying Liu
  • Cynthia L Andoniadou
  • Dietmar Zechner
  • Qiaohong Wang
  • Simon Gosgnach
  • Hemashi K Perera
  • E Bryan Crenshaw
  • Guillermo M Lanuza
  • Sonja Kriks
  • Yu Qiang Ding
  • Dennie M Tompers
  • Henrik Landgren
  • Lara Wine-Lee
  • Ruth K Foreman
  • Alvaro Rada-Iglesias
  • Aboubacrine M Touré
  • Omar Farnos
  • Marisol G Pantovich
  • Yingming Zhao
  • Minjia Tan
  • M Mark Taketo
  • Robert Blelloch
  • Nicolas Pilon
  • Muhammad Danial
  • Vladimir Korinek
  • Thomas Schimmang
  • Guillaume Bernas
  • Joanna Wysocka
  • Ronald J Parchem
  • Peter Frommolt
  • Amy F Chen
  • Ouliana Souchkova
  • Milos Nikolic
  • Paul Elms
  • Chun Liu Zhao
  • Olga Machonova
  • Stefan Krauss
  • Xi Zhou
  • Lan Bao Ding
  • Joe Jiang Zhu
  • Shiyue Zhang
  • Paul Kwong Hang Tam
  • Nripesh Prasad
  • Radhika Aramandla
  • Vincent Chi Hang Lui

Detail Information

Publications61

  1. ncbi The winged-helix transcription factor Foxd3 suppresses interneuron differentiation and promotes neural crest cell fate
    M Dottori
    Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Development 128:4127-38. 2001
    ..In this study, we show that the winged helix transcription factor Foxd3 is expressed in both premigratory and migratory neural crest cells...
  2. pmc Mouse models of Hirschsprung disease and other developmental disorders of the enteric nervous system: Old and new players
    Nadege Bondurand
    INSERM, U955, Equipe 6, F 94000 Creteil, France Université Paris Est, UPEC, F 94000 Creteil, France Electronic address
    Dev Biol 417:139-57. 2016
    ..Finally, because HSCR has become a paradigm for complex oligogenic diseases with non-Mendelian inheritance, the importance of gene interactions, modifier genes, and initial studies on genetic background effects are outlined. ..
  3. pmc Ground-state transcriptional requirements for skin-derived precursors
    Michael T Suflita
    Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA
    Stem Cells Dev 22:1779-88. 2013
    ..Here we show that two well-known stem cell factors, Foxd3 and Sox2, are critical regulators of the stem cell properties of SKPs...
  4. pmc Neural crest and Schwann cell progenitor-derived melanocytes are two spatially segregated populations similarly regulated by Foxd3
    Erez Nitzan
    Department of Medical Neurobiology, IMRIC and ELSC, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Proc Natl Acad Sci U S A 110:12709-14. 2013
    ..Furthermore, although both populations are initially part of the Foxd3 lineage, hypaxial melanocytes lose Foxd3 at late stages upon separation from the nerve, whereas we recently found ..
  5. pmc Advancements and challenges in generating accurate animal models of gestational diabetes mellitus
    Raymond C Pasek
    Tennessee Valley Healthcare System, Department of Veteran Affairs, Nashville, Tennessee
    Am J Physiol Endocrinol Metab 305:E1327-38. 2013
    ..Continued development of animal models of GDM is essential for understanding the consequences of this disease as well as providing insights into potential treatments and preventative measures. ..
  6. pmc Grb2 is regulated by foxd3 and has roles in preventing accumulation and aggregation of mutant huntingtin
    Shounak Baksi
    Structural Genomics Division, Saha Institute of Nuclear Physics, Kolkata, India
    PLoS ONE 8:e76792. 2013
    ..Grb2 overexpression was predominantly regulated by the transcription factor Forkhead Box D3 (Foxd3). Exogenous expression of Grb2 also reduced aggregation of mutant Htt in Neuro2A cells...
  7. pmc Transcriptional targets of Foxd3 in murine ES cells
    Jennifer L Plank
    Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA Center for Stem Cell Biology, Vanderbilt University, Nashville, TN, USA Electronic address
    Stem Cell Res 12:233-40. 2014
    ..The transcription factor Foxd3 is critical for maintenance of self-renewal, survival, and pluripotency in murine embryonic stem cells (ESCs)...
  8. pmc Vascular endothelial growth factor coordinates islet innervation via vascular scaffolding
    Rachel B Reinert
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Development 141:1480-91. 2014
    ....
  9. doi Homeobox b5 (Hoxb5) regulates the expression of Forkhead box D3 gene (Foxd3) in neural crest
    Mandy Ka Man Kam
    Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China
    Int J Biochem Cell Biol 55:144-52. 2014
    ..Current study showed that both the human and mouse Foxd3 promoters were bound and trans-activated by Hoxb5 in NC-derived neuroblastoma cells...
  10. pmc Foxd3 suppresses NFAT-mediated differentiation to maintain self-renewal of embryonic stem cells
    Lili Zhu
    Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes of Biological Sciences Chinese Academy of Sciences Shanghai JiaoTong University School of Medicine, Shanghai, China
    EMBO Rep 15:1286-96. 2014
    Pluripotency-associated transcription factor Foxd3 is required for maintaining pluripotent cells. However, molecular mechanisms underlying its function are largely unknown...
  11. pmc Meis2 is essential for cranial and cardiac neural crest development
    Ondrej Machon
    Institute of Molecular Genetics, The Czech Academy of Sciences, 14200, Praha, Czech Republic
    BMC Dev Biol 15:40. 2015
    ..We have generated a conditional allele of Meis2 in mice and shown that systemic inactivation of the Meis2 gene results in lethality by the embryonic day 14 that is accompanied with hemorrhaging...
  12. pmc FOXD3 Regulates Pluripotent Stem Cell Potential by Simultaneously Initiating and Repressing Enhancer Activity
    Raga Krishnakumar
    The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences, University of California, San Francisco, San Francisco, CA 94143, USA Department of Urology, University of California, San Francisco, San Francisco, CA 94143, USA
    Cell Stem Cell 18:104-17. 2016
    ..during differentiation of embryonic stem to epiblast cells and uncovered the forkhead transcription factor FOXD3 as a major regulator of the developmental potential of both pluripotent states...
  13. pmc Foxd3 Promotes Exit from Naive Pluripotency through Enhancer Decommissioning and Inhibits Germline Specification
    Patricia Respuela
    Center for Molecular Medicine Cologne, University of Cologne, Robert Koch Strasse 21, 50931 Cologne, Germany
    Cell Stem Cell 18:118-33. 2016
    ..regulatory principles orchestrating peri-implantation development, here we show that the transcription factor Foxd3 is necessary for exit from naive pluripotency and progression to a primed pluripotent state...
  14. doi A direct role for murine Cdx proteins in the trunk neural crest gene regulatory network
    Oraly Sanchez-Ferras
    Molecular Genetics of Development Laboratory, Department of Biological Sciences and BioMed Research Center, University of Quebec at Montreal UQAM, Montreal H2X 3Y7, Canada
    Development 143:1363-74. 2016
    ..at least in part, directly controlling the expression of the key early regulators of NC ontogenesis Pax3,Msx1 and Foxd3 Our work thus reveals a novel role for Cdx proteins at the top of the trunk NC gene regulatory network in the ..
  15. pmc An FGF3-BMP Signaling Axis Regulates Caudal Neural Tube Closure, Neural Crest Specification and Anterior-Posterior Axis Extension
    Matthew J Anderson
    Genetics of Vertebrate Development Section, Cancer and Developmental Biology Lab, National Cancer Institute, National Institutes of Health, Frederick, Maryland, United States of America
    PLoS Genet 12:e1006018. 2016
    ..Uncovering this FGF3-BMP signaling axis is a major advance toward understanding how these tissue layers interact during axis extension with important implications in human disease. ..
  16. doi Tcf7l1 protects the anterior neural fold from adopting the neural crest fate
    Jan Masek
    Institute of Molecular Genetics, Academy of Science of the Czech Republic, Prague 142 20, Czech Republic
    Development 143:2206-16. 2016
    ..This reduces the developing prosencephalon without affecting the anterior-posterior neural character. Thus, Tcf7l1 defines the border between the NC and the prospective forebrain via restriction of the Wnt/β-catenin signaling gradient. ..
  17. doi FOXD3 suppresses tumor growth and angiogenesis in non-small cell lung cancer
    Jun Hai Yan
    Department of Respiratory Medicine, Luwan Branch of Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 20020, China
    Biochem Biophys Res Commun 466:111-6. 2015
    The transcription factor forkhead box D3 (FOXD3), widely studied as a transcriptional repressor in embryogenesis, participates in the carcinogenesis of many cancers...
  18. pmc Characterization of the Gbx1-/- mouse mutant: a requirement for Gbx1 in normal locomotion and sensorimotor circuit development
    Desire M Buckley
    Division of Biological Sciences, University of Missouri, Columbia, Missouri, United States of America
    PLoS ONE 8:e56214. 2013
    ..The generation of this null allele has enabled us to functionally characterize a novel role for Gbx1 in development of the spinal cord...
  19. pmc Cardiovascular defects in a mouse model of HOXA1 syndrome
    Nadja Makki
    Howard Hughes Medical Institute and Department of Human Genetics, University of Utah, Salt Lake City, UT 84112 5331, USA
    Hum Mol Genet 21:26-31. 2012
    ..Thus, our data allow us to suggest a model in which Hoxa1 regulates heart development through its influence on cardiac NCCs, providing insight into the mechanisms underlying the human disease...
  20. pmc Loss of Foxd3 results in decreased β-cell proliferation and glucose intolerance during pregnancy
    Jennifer L Plank
    Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 0494, USA
    Endocrinology 152:4589-600. 2011
    ..The transcription factor Forkhead box D3 (Foxd3) is required for maintenance and self-renewal of several diverse progenitor cell lineages, and Foxd3 is expressed ..
  21. pmc Sox2 and Mitf cross-regulatory interactions consolidate progenitor and melanocyte lineages in the cranial neural crest
    Igor Adameyko
    Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 17177 Stockholm, Sweden
    Development 139:397-410. 2012
    ....
  22. pmc Enteric nervous system specific deletion of Foxd3 disrupts glial cell differentiation and activates compensatory enteric progenitors
    Nathan A Mundell
    Center for Stem Cell Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Dev Biol 363:373-87. 2012
    ..Our earlier work demonstrated that the transcription factor Foxd3 is required early in neural crest-derived progenitors for self-renewal, multipotency and establishment of multiple ..
  23. doi Helicobacter pylori causes epigenetic dysregulation of FOXD3 to promote gastric carcinogenesis
    Alfred S L Cheng
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China
    Gastroenterology 144:122-133.e9. 2013
    ..Promoter hypermethylation occurs during Helicobacter pylori-induced gastritis. We investigated whether the deregulated genes contribute to gastric tumorigenesis...
  24. pmc Interaction between DMRT1 function and genetic background modulates signaling and pluripotency to control tumor susceptibility in the fetal germ line
    Anthony D Krentz
    Department of Genetics, Cell Biology, and Development, Developmental Biology Center, and Masonic Cancer Center, University of Minnesota, 6 160 Jackson Laboratory, 321 Church St SE, Minneapolis, MN 55455, USA
    Dev Biol 377:67-78. 2013
    ..Given the strong evidence for involvement of DMRT1 in human TGCT, the downstream genes and pathways identified in this study provide potentially useful candidates for roles in the human disease...
  25. pmc Renshaw cell interneuron specialization is controlled by a temporally restricted transcription factor program
    Floor J Stam
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Development 139:179-90. 2012
    ..The development of RCs is additionally dependent on the forkhead transcription factor Foxd3, which is more broadly expressed in postmitotic V1 interneurons...
  26. pmc A dynamic code of dorsal neural tube genes regulates the segregation between neurogenic and melanogenic neural crest cells
    Erez Nitzan
    Department of Medical Neurobiology, IMRIC and ELSC, Hebrew University, Hadassah Medical School, Jerusalem 91120, PO Box 12272, Israel
    Development 140:2269-79. 2013
    ..Analysis of progenitors expressing a Foxd3 reporter reveals that prospective melanoblasts downregulate Foxd3 and have already segregated from neural lineages ..
  27. pmc Neural crest stem cell multipotency requires Foxd3 to maintain neural potential and repress mesenchymal fates
    Nathan A Mundell
    Center for Stem Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 0494, USA
    Development 138:641-52. 2011
    ..Our earlier work demonstrated that Foxd3 is required for maintenance of NC progenitors in the embryo...
  28. pmc Functional interaction between Foxd3 and Pax3 in cardiac neural crest development
    Brian L Nelms
    Vanderbilt University Medical Center, Department of Cell and Developmental Biology, Center for Stem Cell Biology, Program in Developmental Biology, Nashville, Tennessee, USA
    Genesis 49:10-23. 2011
    The transcription factors Foxd3 and Pax3 are important early regulators of neural crest (NC) progenitor cell properties...
  29. pmc Disrupted dorsal neural tube BMP signaling in the cilia mutant Arl13b hnn stems from abnormal Shh signaling
    Vanessa L Horner
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Dev Biol 355:43-54. 2011
    ..We demonstrate that Arl13b is required non-autonomously for BMP signaling and Wnt ligand expression, indicating that the abnormal Shh signaling environment in Arl13b(hnn) embryos indirectly causes dorsal defects...
  30. pmc The microenvironment patterns the pluripotent mouse epiblast through paracrine Furin and Pace4 proteolytic activities
    Daniel Mesnard
    Ecole Polytechnique Fédérale de Lausanne EPFL SV ISREC, CH 1015 Lausanne, Switzerland
    Genes Dev 25:1871-80. 2011
    ..Adding cell-cell communication to the pleiotropic portfolio of these proteases provides a new framework to study proprotein processing also in other relevant contexts...
  31. pmc Influence and timing of arrival of murine neural crest on pancreatic beta cell development and maturation
    Jennifer L Plank
    Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Dev Biol 349:321-30. 2011
    ..Using a neural crest-specific deletion of the Forkhead transcription factor Foxd3, we ablated neural crest cells that migrate to the pancreatic primordium...
  32. pmc Ventral migration of early-born neurons requires Dcc and is essential for the projections of primary afferents in the spinal cord
    Yu Qiang Ding
    Department of Anesthesiology, School of Medicine, Washington University Pain Center, St Louis, MO 63110, USA
    Development 132:2047-56. 2005
    ....
  33. ncbi Members of the HNF-3/forkhead family of transcription factors exhibit distinct cellular expression patterns in lung and regulate the surfactant protein B promoter
    D E Clevidence
    Department of Biochemistry M C 536, College of Medicine, University of Illinois at Chicago 60612 7334
    Dev Biol 166:195-209. 1994
    ..Our results suggest that SPB promoter activity is regulated by HNF-3 alpha and HFH-8 proteins in a cell type-specific manner...
  34. ncbi Genesis, a winged helix transcriptional repressor with expression restricted to embryonic stem cells
    J Sutton
    Division of Hematology Oncology and the Walther Oncology Center, IB 442, Indiana University Medical Center, Indianapolis, Indiana 46202 5121, USA
    J Biol Chem 271:23126-33. 1996
    A novel member of the winged helix (formerly HNF-3/Forkhead) transcriptional regulatory family, termed Genesis, was isolated and characterized...
  35. ncbi Forced expression of Genesis, a winged helix transcriptional repressor isolated from embryonic stem cells, blocks granulocytic differentiation of 32D myeloid cells
    D Xu
    Division of Hematology Oncology and the Walther Oncology Center, Indiana University Medical Center, Indianapolis 46202 5121, USA
    Leukemia 12:207-12. 1998
    ..a novel member of the winged helix (formerly HNF-3/Forkhead) transcriptional regulatory family, termed Genesis. Genesis was found to be a transcriptional repressor expressed almost exclusively in embryonic stem cells or ..
  36. ncbi The winged helix transcription factor Hfh2 is expressed in neural crest and spinal cord during mouse development
    P A Labosky
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, 36th and Hamilton Walk, Philadelphia, PA 19104 6058, USA
    Mech Dev 76:185-90. 1998
    ..Here we demonstrate that Hfh2 (HNF3 forkhead homologue 2), a member of the 'winged helix' or 'forkhead' transcription factor gene family, is ..
  37. ncbi Developmental competence of the gut endoderm: genetic potentiation by GATA and HNF3/fork head proteins
    K Zaret
    Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island 02912, USA
    Dev Biol 209:1-10. 1999
    ..The mechanistic implications of genetic potentiation and its general significance are discussed...
  38. pmc Neurogenin1 and neurogenin2 control two distinct waves of neurogenesis in developing dorsal root ganglia
    Q Ma
    Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Genes Dev 13:1717-28. 1999
    ..These data reveal remarkable parallels in the roles of bHLH factors during neurogenesis in the DRG, and myogenesis in the neighboring myotome...
  39. ncbi Lbx1 specifies somatosensory association interneurons in the dorsal spinal cord
    Michael K Gross
    Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuron 34:535-49. 2002
    ..Lbx1, therefore, plays a critical role in the development of sensory pathways in the spinal cord that relay pain and touch...
  40. pmc Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo
    Lynn A Hanna
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6058, USA
    Genes Dev 16:2650-61. 2002
    ..Here, we report that Foxd3, a member of the forkhead family of transcriptional regulators, is required for maintenance of embryonic cells of ..
  41. ncbi An amphioxus winged helix/forkhead gene, AmphiFoxD: insights into vertebrate neural crest evolution
    Jr Kai Yu
    Marine Biology Research Division, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093 0202, USA
    Dev Dyn 225:289-97. 2002
    ..Phylogenetic analysis indicates that the AmphiFoxD is basal to vertebrate FoxD1, FoxD2, FoxD3, FoxD4, and FoxD5. One of these vertebrate genes (FoxD3) consistently marks neural crest during development...
  42. ncbi Zic2 is required for neural crest formation and hindbrain patterning during mouse development
    Paul Elms
    Laboratory of Early Development, Mammalian Genetics Unit, MRC, Harwell, Oxfordshire, OX11 ORD, UK
    Dev Biol 264:391-406. 2003
    ..This work provides the first genetic evidence that the Zic genes are involved in neural crest production and the first demonstration that Zic2 functions during hindbrain patterning...
  43. ncbi Cardiac outflow tract defects in mice lacking ALK2 in neural crest cells
    Vesa Kaartinen
    Developmental Biology Program, The Saban Research Institute of Childrens Hospital Los Angeles, Departments of Pathology and Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Development 131:3481-90. 2004
    ..Thus, the type I BMP receptor ALK2 plays an essential cell-autonomous role in the development of the cardiac outflow tract and aortic arch derivatives...
  44. ncbi FoxJ3, a novel mammalian forkhead gene expressed in neuroectoderm, neural crest, and myotome
    Henrik Landgren
    Department of Cell and Molecular Biology, Goteborg University, Goteborg, Sweden
    Dev Dyn 231:396-401. 2004
    ..Developing limbs have a complex pattern of Foxj3 expression that at E12.5 colocalizes with the condensed mesenchyme of the skeletal primordia...
  45. pmc The bHLH factor Olig3 coordinates the specification of dorsal neurons in the spinal cord
    Thomas Muller
    Max Delbruck Center for Molecular Medicine, 13122 Berlin, Germany
    Genes Dev 19:733-43. 2005
    ..We conclude that Olig3 expression distinguishes the two major classes of progenitors in the dorsal spinal cord and determines the distinct specification program of class A neurons...
  46. pmc Two Notch ligands, Dll1 and Jag1, are differently restricted in their range of action to control neurogenesis in the mammalian spinal cord
    Catarina Ramos
    Faculdade de Medicina de Lisboa, Instituto de Medicina Molecular, Lisboa, Portugal
    PLoS ONE 5:e15515. 2010
    ..However, the specific contribution of different ligands to regulate neurogenesis in vertebrate embryos is still poorly understood...
  47. ncbi Gsh2 is required for the repression of Ngn1 and specification of dorsal interneuron fate in the spinal cord
    Sonja Kriks
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Development 132:2991-3002. 2005
    ..Our results provide evidence that genetic interactions involving repression of Ngn1 by Gsh2 promote the differentiation of dI3 neurons from class A progenitors...
  48. ncbi Foxd3 is required in the trophoblast progenitor cell lineage of the mouse embryo
    Dennie M Tompers
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104 6058, USA
    Dev Biol 285:126-37. 2005
    ..The transcriptional repressor Foxd3 is required for maintenance of the epiblast and the in vitro establishment of embryonic stem cell lines...
  49. ncbi V1 spinal neurons regulate the speed of vertebrate locomotor outputs
    Simon Gosgnach
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 440:215-9. 2006
    ....
  50. ncbi Expression and shifting subcellular localization of the transcription factor, Foxd3, in embryonic and adult pancreas
    Hemashi K Perera
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104 6058, USA
    Gene Expr Patterns 6:971-7. 2006
    ..b>Foxd3, a member of the forkhead family of transcriptional regulators, is required for the maintenance of embryonic stem ..
  51. ncbi Bmp and Wnt/beta-catenin signals control expression of the transcription factor Olig3 and the specification of spinal cord neurons
    Dietmar Zechner
    Max Delbrück Center of Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Dev Biol 303:181-90. 2007
    ..We conclude that Wnt/beta-catenin and BMP signals coordinately control the specification of dorsal neurons in the spinal cord...
  52. pmc Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain
    Cynthia L Andoniadou
    Neural Development Unit, UCL Institute of Child Health, 30 Guilford Street, WC1N 1EH, London, UK
    Development 134:1499-508. 2007
    ..However, conditional expression of Hesx1 within the AFB can rescue the forebrain defects observed in the Hesx1 mutants. The results presented here provide new insights into the function of Hesx1 in forebrain formation...
  53. pmc Requirement for Foxd3 in the maintenance of neural crest progenitors
    Lu Teng
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
    Development 135:1615-24. 2008
    ..b>Foxd3 is required early in mouse embryogenesis; Foxd3(-/-) embryos fail around the time of implantation, cells of the ..
  54. pmc Regulation of embryonic stem cell self-renewal and pluripotency by Foxd3
    Ying Liu
    Department of Cell and Developmental Biology, Center for Stem Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0494, USA
    Stem Cells 26:2475-84. 2008
    The Foxd3 forkhead transcription factor is required for maintaining pluripotent cells in the early mouse embryo and for the establishment of murine embryonic stem cell (ESC) lines...
  55. doi The bHLH transcription factor Olig3 marks the dorsal neuroepithelium of the hindbrain and is essential for the development of brainstem nuclei
    Robert Storm
    Max Delbrück Centrum for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Development 136:295-305. 2009
    ..Climbing fiber neurons of the inferior olivary nucleus express Foxd3 and require Olig3 as well as Ptf1a for the determination of their fate...
  56. pmc Identification and subclassification of new Atoh1 derived cell populations during mouse spinal cord development
    George R Miesegaes
    Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Dev Biol 327:339-51. 2009
    ..Altogether we reveal the existence of multiple Atoh1 dependent cell types in the spinal cord, and uncover a novel progenitor domain that arises late in development...
  57. doi Epigenetic priming of a pre-B cell-specific enhancer through binding of Sox2 and Foxd3 at the ESC stage
    Daniel Liber
    MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    Cell Stem Cell 7:114-26. 2010
    ..Binding of Foxd3 suppresses intergenic transcription of the enhancer and surrounding sequences...
  58. pmc Fibronectin and integrin alpha 5 play essential roles in the development of the cardiac neural crest
    Ashok Mittal
    Weill Cornell Medical College, Department of Medicine, Division of Cardiology, New York, NY, USA
    Mech Dev 127:472-84. 2010
    ..However, we found that FN and integrin α5 modulate CNC proliferation and survival, and are required for the presence of normal numbers of CNC cells at their destinations...
  59. pmc Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst
    Daniel Mesnard
    Swiss Federal Institute of Technology Lausanne, School of Life Sciences, Swiss Institute for Experimental Cancer Research, CH 1015 Lausanne, Switzerland
    J Cell Biol 191:129-39. 2010
    ..The unprecedented sensitivity and spatial resolution of CLIP opens exciting new possibilities to elucidate PC functions in vivo...
  60. pmc Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family
    D E Clevidence
    Department of Biochemistry M C 536, University of Illinois College of Medicine, Chicago 60612
    Proc Natl Acad Sci U S A 90:3948-52. 1993
    ..The HNF-3/fkh motif therefore comprises a large gene family of transcription factors that play a role in tissue-specific gene regulation and development...
  61. ncbi Signaling through BMP type 1 receptors is required for development of interneuron cell types in the dorsal spinal cord
    Lara Wine-Lee
    Mammalian Neurogenetics Group, Center for Childhood Communication, 712 Abramsom Research Center, The Children s Hospital of Philadelphia, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Development 131:5393-403. 2004
    ..These results provide genetic evidence that BMP signaling is crucial for the development of dorsal neuronal cell types...

Research Grants3

  1. Functional Analysis of Spinal Cord Interneurons
    Martyn Goulding; Fiscal Year: 2005
    ..These studies will provide valuable insights into the development and organization of circuits in the spinal cord that control locomotor behavior, and will lay the groundwork for strategies to treat spinal cord injury and degeneration. ..
  2. Specification of Dorsal Lbx1-Derived Interneurons
    Martyn Goulding; Fiscal Year: 2007
    ..These studies will provide important insights into the development and organization of neural circuits in the dorsal horn that sense and relay pain. [unreadable] [unreadable] [unreadable]..
  3. Neural crest formation and maintenance of multipotency
    Patricia Labosky; Fiscal Year: 2009
    ..We have identified a transcription factor, Foxd3 that is sufficient to specify neural crest...