Genomes and Genes
Gene Symbol: Gfap
Description: glial fibrillary acidic protein
Alias: AI836096, glial fibrillary acidic protein, intermediate filament protein
Publications174 found, 100 shown here
- Targeted deletion in astrocyte intermediate filament (Gfap) alters neuronal physiologyM A McCall
Department of Pathobiological Sciences, University of Wisconsin Madison, 53706, USA
Proc Natl Acad Sci U S A 93:6361-6. 1996b>Glial fibrillary acidic protein (GFAP) is a member of the family of intermediate filament structural proteins and is found predominantly in astrocytes of the central nervous system (CNS)...
- An obligatory role of mind bomb-1 in notch signaling of mammalian developmentBon Kyoung Koo
Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, South Korea
PLoS ONE 2:e1221. 2007..However, the respective roles of the mammalian E3 ubiquitin ligases, Neur1, Neur2, Mib1, and Mib2, in mammalian development are poorly understood...
- Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of ShhRebecca Favaro
Department of Biotechnology and Biosciences, University of Milano Bicocca, Milano, Italy
Nat Neurosci 12:1248-56. 2009..Their replication was partially rescued by the addition of SHH and was almost fully rescued by conditioned medium from normal cells. Thus, NSCs control their status, at least partly, through Sox2-dependent autocrine mechanisms...
- Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signalingYingwei Mao
Howard Hughes Medical Institute, Cambridge, MA 02139, USA
Cell 136:1017-31. 2009..Together, these results implicate DISC1 in GSK3beta/beta-catenin signaling pathways and provide a framework for understanding how alterations in this pathway may contribute to the etiology of psychiatric disorders...
- Pet-1 is required across different stages of life to regulate serotonergic functionChen Liu
Case Western Reserve University, School of Medicine, Department of Neurosciences, Cleveland, Ohio, USA
Nat Neurosci 13:1190-8. 2010..These findings indicate that Pet-1 is required across the lifespan of the mouse and that behavioral pathogenesis can result from both developmental and adult-onset alterations in serotonergic transcription...
- Inactivation of the glial fibrillary acidic protein gene, but not that of vimentin, improves neuronal survival and neurite growth by modifying adhesion molecule expressionV Menet
Institut National de la Santé et de la Recherche Médicale U336, Universite Montpellier II, F 34095 Montpellier, France
J Neurosci 21:6147-58. 2001..In mature differentiated astrocytes, vimentin is replaced by the IF protein glial fibrillary acidic protein (GFAP)...
- Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrainAnil Bagri
Department of Anatomy, Howard Hughes Medical Institute, CA, USA
Neuron 33:233-48. 2002....
- Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connectionQ Richard Lu
Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
Cell 109:75-86. 2002..Neither Olig gene is required for astrocytes. These findings, together with fate mapping analysis of Olig-expressing cells, indicate that oligodendrocytes are derived from Olig-specified progenitors that give rise also to neurons...
- Multiple Eph receptors and B-class ephrins regulate midline crossing of corpus callosum fibers in the developing mouse forebrainShannon W Mendes
Neuroscience Program, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
J Neurosci 26:882-92. 2006..Our results support a significant role for ephrins and Eph receptors in CC development and may provide insight to possible mechanisms involved in axon midline crossing and human disorder...
- FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasisJi Hye Paik
Department of Medical Oncology, Belfer Institute for Applied Cancer Science, Harvard Medical School, Boston, MA 02115, USA
Cell Stem Cell 5:540-53. 2009..Thus, the FoxO family coordinately regulates diverse genes and pathways to govern key aspects of NSC homeostasis in the mammalian brain...
- A novel glial fibrillary acidic protein mRNA lacking exon 1D Zelenika
C N R S U P R 9035, Paris, France
Brain Res Mol Brain Res 30:251-8. 1995b>Glial fibrillary acidic protein (GFAP) is the major intermediate filament protein in the mature astrocytes. We have assayed for the presence of GFAP mRNA gene in mouse tissues outside the nervous system...
- Altered emotional behavioral responses in mice lacking brain-type fatty acid-binding protein geneYuji Owada
Division of Histology, Graduate School of Medical Science, Tohoku University, 2 1 Seiryo machi, Aobaku, Sendai 980 8575, Japan
Eur J Neurosci 24:175-87. 2006..These data indicate that B-FABP is crucially involved in the fear memory and anxiety through its binding with FAs and/or its own direct effects on pertinent metabolism/signaling of FAs...
- Alexander disease-associated glial fibrillary acidic protein mutations in mice induce Rosenthal fiber formation and a white matter stress responseTracy L Hagemann
Waisman Center, University of Wisconsin, Madison, Wisconsin 53705, USA
J Neurosci 26:11162-73. 2006Mutations in the gene for the astrocyte specific intermediate filament, glial fibrillary acidic protein (GFAP), cause the rare leukodystrophy Alexander disease (AxD)...
- Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and mTOR signaling pathwaysGuomei Tang
Department of Pathology, Center for Neurobiology and Behavior, Center for Parkinson s Disease and Other Movement Disorders, Columbia University, New York, NY 10032, USA
Hum Mol Genet 17:1540-55. 2008b>Glial fibrillary acidic protein (GFAP) is the principle intermediate filament (IF) protein in astrocytes...
- Differential patterns of nestin and glial fibrillary acidic protein expression in mouse hippocampus during postnatal developmentJoong Sun Kim
Department of Veterinary Anatomy, College of Veterinary Medicine, Chonnam National University, Gwangju 500 757, Korea
J Vet Sci 12:1-6. 2011Intermediate filaments, including nestin and glial fibrillary acidic protein (GFAP), are important for the brain to accommodate neural activities and changes during development...
- Expression of disrupted in schizophrenia 1 (DISC1) protein in the adult and developing mouse brain indicates its role in neurodevelopmentI L Schurov
Merck Sharp and Dohme, The Neuroscience Research Centre, Terlings Park, Harlow, Essex CM20 2QR, UK
Mol Psychiatry 9:1100-10. 2004..Together, these results suggest that DISC1 may play a critical role in brain development, consistent with the neurodevelopmental hypothesis of the etiology of schizophrenia...
- Histone deacetylases 1 and 2 are expressed at distinct stages of neuro-glial developmentJessica L MacDonald
Department of Zoology, University of British Columbia, Vancouver, Canada
Dev Dyn 237:2256-67. 2008..These results identify key developmental stages of HDAC expression and suggest transitions of neural development that may utilize HDAC1 and/or HDAC2...
- Developmental expression of prion protein and its ligands stress-inducible protein 1 and vitronectinGlaucia N M Hajj
Ludwig Institute for Cancer Research, São Paulo 01323 903, Brazil
J Comp Neurol 517:371-84. 2009..Finally, although STI1 and Vn are PrP(C) ligands, their expression was not altered in PrP(C)-null mice...
- Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicityHiroki Shiwaku
Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
EMBO J 29:2446-60. 2010..Collectively, these results suggest that the reduction of Maxer mediates functional deficiency of Bergmann glia, and might contribute to the non-cell-autonomous pathology of SCA1...
- A new splice variant of glial fibrillary acidic protein, GFAP epsilon, interacts with the presenilin proteinsAnders Lade Nielsen
Department of Human Genetics, University of Aarhus, Denmark
J Biol Chem 277:29983-91. 2002We describe a new human isoform, GFAP epsilon, of the intermediary filament protein GFAP (glial fibrillary acidic protein)...
- Enhanced hippocampal neurodegeneration after traumatic or kainate excitotoxicity in GFAP-null miceNaoki Otani
Department of Neurosurgery, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
J Clin Neurosci 13:934-8. 2006..Recent evidence suggests that the upregulation of glial fibrillary acidic protein (GFAP), an astrocyte-specific intermediate filament component, is a biological marker of ..
- Bmi-1 over-expression in neural stem/progenitor cells increases proliferation and neurogenesis in culture but has little effect on these functions in vivoShenghui He
Howard Hughes Medical Institute, Department of Internal Medicine, Center for Stem Cell Biology, University of Michigan, 5435 Life Sciences Institute, 210 Washtenaw Ave, Ann Arbor, MI 48109 2216, USA
Dev Biol 328:257-72. 2009..Bmi-1 over-expression therefore has more pronounced effects in culture and does not appear to be sufficient to induce tumorigenesis in vivo...
- Developmental requirement of gp130 signaling in neuronal survival and astrocyte differentiationK Nakashima
Department of Molecular Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, 101 0062, Japan
J Neurosci 19:5429-34. 1999..Moreover, expression of an astrocyte marker, GFAP, was severely reduced in the brain of gp130 -/- mice...
- Robo1 regulates the development of major axon tracts and interneuron migration in the forebrainWilliam Andrews
Department of Anatomy and Developmental Biology, University College London, UK
Development 133:2243-52. 2006....
- Murine model of Alexander disease: analysis of GFAP aggregate formation and its pathological significanceKenji F Tanaka
Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, Okazaki 444 8787, Japan
Glia 55:617-31. 2007Alexander disease is caused by a coding mutation in the glial fibrillary acidic protein (GFAP) gene...
- Identification of a transient subpial neurogenic zone in the developing dentate gyrus and its regulation by Cxcl12 and reelin signalingGuangnan Li
Department of Neurology, UCSF School of Medicine, San Francisco, CA 94158, USA
Development 136:327-35. 2009..These results demonstrate that the relocation of neural precursors in the dentate gyrus consists of discrete steps regulated by multiple pathways...
- Expression of the tight junction protein ZO-1 in the olfactory system: presence of ZO-1 on olfactory sensory neurons and glial cellsF Miragall
Institut fur Anatomie, Universitat Regensburg, Germany
J Comp Neurol 341:433-48. 1994..Cell cultures of olfactory bulbs showed ZO-1 immunoreaction, mostly localized on glial fibrillary acidic protein (GFAP)-positive cells...
- Netrin-1 is required for the normal development of spinal cord oligodendrocytesHui Hsin Tsai
Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Neurosci 26:1913-22. 2006..These data indicate that netrin-1 is crucial for both the initial dispersal of spinal cord oligodendrocyte precursors and their subsequent development in the presumptive white matter...
- Nestin mRNA expression correlates with the central nervous system progenitor cell state in many, but not all, regions of developing central nervous systemJ Dahlstrand
Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, Stockholm, Sweden
Brain Res Dev Brain Res 84:109-29. 1995....
- Abnormal reaction to central nervous system injury in mice lacking glial fibrillary acidic protein and vimentinM Pekny
Department of Medical Biochemistry, Gothenburg University, SE 405 30 Gothenburg, Sweden
J Cell Biol 145:503-14. 1999..system, astrocytes become reactive and express high levels of the intermediate filament (IF) proteins glial fibrillary acidic protein (GFAP), vimentin, and nestin...
- Mice devoid of the glial fibrillary acidic protein develop normally and are susceptible to scrapie prionsH Gomi
Institute for Virus Research, Kyoto University, Japan
Neuron 14:29-41. 1995b>Glial fibrillary acidic protein (GFAP) is an intermediate filament protein specifically expressed in astrocytes in the CNS. To examine the function of GFAP in vivo, the Gfap gene was disrupted by gene targeting in embryonic stem cells...
- Neural precursor differentiation into astrocytes requires signaling through the leukemia inhibitory factor receptorS A Koblar
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, 3050 Australia
Proc Natl Acad Sci U S A 95:3178-81. 1998..the low-affinity leukemia inhibitory factor receptor (LIFR-/-) fail to generate astrocytes expressing glial fibrillary acidic protein (GFAP) when cultured in vitro...
- Multipotential progenitors of the mammalian enteric nervous system capable of colonising aganglionic bowel in organ cultureD Natarajan
Divisions of Developmental Neurobiology and Cellular Immunology, MRC, National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK
Development 126:157-68. 1999..Our data show the NC-derived RET+ population of fetal gut in mammalian embryos consists of multipotential progenitors capable of colonising efficiently both wild-type and RET-deficient aganglionic bowel in organ culture...
- Protective role of phosphorylation in turnover of glial fibrillary acidic protein in miceMasaaki Takemura
Laboratory for Behavioral Genetics, RIKEN Brain Science Institute, Wako 351 0198, Japan
J Neurosci 22:6972-9. 2002b>Glial fibrillary acidic protein (GFAP), the principal intermediate filament (IF) protein of mature astrocytes in the CNS, plays specific roles in astrocyte functions. GFAP has multiple phosphorylation sites at its N-terminal head domain...
- The Sox9 transcription factor determines glial fate choice in the developing spinal cordC Claus Stolt
Institut fur Biochemie, Universität Erlangen Nuremberg, 91054 Erlangen, Germany
Genes Dev 17:1677-89. 2003....
- Mapping spatio-temporal activation of Notch signaling during neurogenesis and gliogenesis in the developing mouse brainAkinori Tokunaga
Department of Physiology, Keio University School of Medicine, Tokyo, Japan
J Neurochem 90:142-54. 2004..Taken together, the present method has enabled us to determine the timing, gradients, and boundaries of the activation of Notch signaling...
- Mitotic spindle regulation by Nde1 controls cerebral cortical sizeYuanyi Feng
Department of Neurology, Howard Hughes Medical Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Neuron 44:279-93. 2004..In vitro analysis demonstrated that Nde1 is essential for centrosome duplication and mitotic spindle assembly. Our data show that mitotic spindle function and orientation are essential for normal development of mammalian cerebral cortex...
- Dynamics of mutated GFAP aggregates revealed by real-time imaging of an astrocyte model of Alexander diseaseCyril Mignot
INSERM UMR S 546, Paris, France
Exp Cell Res 313:2766-79. 2007..in astrocytes and myelin abnormalities and caused by dominant mutations in the gene encoding glial fibrillary acidic protein (GFAP), the main intermediate filament protein in astrocytes...
- Lack of the endosomal SNAREs vti1a and vti1b led to significant impairments in neuronal developmentAjaya J Kunwar
Department of Neuroanatomy, Center of Anatomy, University of Gottingen, 37075 Gottingen, Germany
Proc Natl Acad Sci U S A 108:2575-80. 2011..Vti1a(-/-) and Vti1b(-/-) single deficient mice were viable without these neuronal defects, indicating that they can substitute for each other in these processes...
- Pax3: a paired domain gene as a regulator in PNS myelinationC Kioussi
Abteilung für Molekulare Zellbiologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Federal Republic of Germany
Neuron 15:553-62. 1995..Treating cultures with forskolin, an adenylate cyclase agonist, repressed Pax3 RNA, GFAP, NGFR, N-CAM, and L1 and elevated MBP...
- Mice lacking glial fibrillary acidic protein display astrocytes devoid of intermediate filaments but develop and reproduce normallyM Pekny
Department of Medical Biochemistry, University of Goteborg, Sweden
EMBO J 14:1590-8. 1995b>Glial fibrillary acidic protein (GFAP) is the main component of the intermediate filaments in cells of astroglial lineage, including astrocytes in the CNS, nonmyelin forming Schwann cells and enteric glia...
- Disrupted glial fibrillary acidic protein network in astrocytes from vimentin knockout miceM Galou
Unité de Biochimie des Antigènes, Institut Pasteur, Paris, France
J Cell Biol 133:853-63. 1996b>Glial fibrillary acidic protein (GFAP) is an intermediate filament protein expressed predominantly in astrocytes...
- Altered taurine release following hypotonic stress in astrocytes from mice deficient for GFAP and vimentinM Ding
Department of Anatomy and Cell Biology, University of Goteborg, PO Box 420, SE 405 30, Goteborg, Sweden
Brain Res Mol Brain Res 62:77-81. 1998..Astrocytes from wild type mice were compared with cells from mice deficient for either glial fibrillary acidic protein (GFAP-/-) or vimentin (vimentin-/-) and with astrocytes from mice deficient for both proteins (GFAP-/-..
- Intermediate filament protein partnership in astrocytesC Eliasson
Department of Medical Biochemistry, University of Gothenburg, SE 405 30 Gothenburg, Sweden
J Biol Chem 274:23996-4006. 1999..Astrocytes may express three types of intermediate filament proteins: glial fibrillary acidic protein (GFAP), vimentin, and nestin...
- Characterization of elongation factor-1A (eEF1A-1) and eEF1A-2/S1 protein expression in normal and wasted miceA Khalyfa
Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, The Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec H3T 1E2, Canada
J Biol Chem 276:22915-22. 2001....
- Development of the perforating pathway: an ipsilaterally projecting pathway between the medial septum/diagonal band of Broca and the cingulate cortex that intersects the corpus callosumT Shu
Department of Anatomy and Neurobiology, School of Medicine, The University of Maryland, Baltimore, Baltimore, Maryland 21201, USA
J Comp Neurol 436:411-22. 2001..These findings show that ipsilaterally projecting PFP axons and contralaterally projecting callosal axons make distinct guidance decisions at the same developmental stage when they reach the corticoseptal boundary...
- The neuronal basic helix-loop-helix transcription factor NSCL-1 is dispensable for normal neuronal developmentMarkus Krüger
Institute of Physiological Chemistry, University of Halle Wittenberg, 06097 Halle, Germany
Mol Cell Biol 22:792-800. 2002..Our results argue against a simple functional redundancy within the NSCL gene family...
- Decrease in expression of alpha 5 beta 1 integrin during neuronal differentiation of cortical progenitor cellsNaoko Yoshida
Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan
Exp Cell Res 287:262-71. 2003..These findings suggest that alpha(5)beta(1) expression on cortical progenitor cells is developmentally regulated and its downregulation is involved in the process of neuronal differentiation...
- Deletion of macrophage-inflammatory protein 1 alpha retards neurodegeneration in Sandhoff disease miceYun Ping Wu
Genetics of Development and Disease Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 101:8425-30. 2004....
- Fibroblast growth factor receptor 1 is required for the proliferation of hippocampal progenitor cells and for hippocampal growth in mouseYasushi Ohkubo
Child Study Center, Yale University, New Haven, Connecticut 06520, USA
J Neurosci 24:6057-69. 2004..of "floxed" Fgfr1 alleles was directed to cells of the radial glial lineage by using the human glial fibrillary acidic protein promoter...
- Homologues of the Caenorhabditis elegans Fox-1 protein are neuronal splicing regulators in mammalsJason G Underwood
Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California 90095 1662, USA
Mol Cell Biol 25:10005-16. 2005..They do this through a splicing enhancer function, in addition to their apparent negative effects on splicing in vertebrate muscle and in worms...
- Notch 2 and Notch 1/3 segregate to neuronal and glial lineages of the developing olfactory epitheliumChristine Carson
Department of Zoology, University of British Columbia, Vancouver, BC, Canada
Dev Dyn 235:1678-88. 2006..Notch 2 and Notch 1/3 may, therefore, have different roles in the commitment and differentiation of neuronal and glial lineages of the OE during development, and the maintenance of non-neuronal phenotypes postnatally...
- Midline radial glia translocation and corpus callosum formation require FGF signalingKAREN MULLER SMITH
Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Nat Neurosci 9:787-97. 2006..Hence, FGFs have an important role in the transition from radial glia to astrocytes by stimulating somal translocation of radial glial cells...
- The Wnt receptor Ryk is required for Wnt5a-mediated axon guidance on the contralateral side of the corpus callosumThomas R Keeble
The Queensland Brain Institute, University of Queensland, Brisbane, Queensland 4072, Australia
J Neurosci 26:5840-8. 2006..Our analysis of Ryk function further advances our understanding of the molecular mechanisms underlying the formation of this important commissure...
- Physiological Notch signaling promotes gliogenesis in the developing peripheral and central nervous systemsMerritt K Taylor
Howard Hughes Medical Institute, Life Sciences Institute, Department of Internal Medicine, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, MI 48109 2216, USA
Development 134:2435-47. 2007..These results demonstrate that physiological Notch signaling is required for gliogenesis in vivo, independent of the role of Notch in the maintenance of undifferentiated neural progenitors...
- Expression of Disabled 1 suppresses astroglial differentiation in neural stem cellsIl Sun Kwon
Department of Anatomy, School of Medicine, Ajou University, Suwon, 443 749, South Korea
Mol Cell Neurosci 40:50-61. 2009..Differentiating Dab1(-/-) neurospheres exhibited a higher expression of GFAP, an astrocytic marker, at the expense of neuronal markers...
- Disruption of Nectin-like 1 cell adhesion molecule leads to delayed axonal myelination in the CNSJinsil Park
Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, Kentucky 40292, USA
J Neurosci 28:12815-9. 2008....
- NeuN, a neuronal specific nuclear protein in vertebratesR J Mullen
Department of Anatomy, University of Utah School of Medicine, Salt Lake City 84132
Development 116:201-11. 1992..This mAb and the protein recognized by it serve as an excellent marker for neurons in the central and peripheral nervous systems in both the embryo and adult, and the protein may be important in the determination of neuronal phenotype...
- Cell and molecular analysis of the developing and adult mouse subventricular zone of the cerebral hemispheresM A Gates
Department of Anatomy and Neurobiology, University of Tennessee, Memphis 38163, USA
J Comp Neurol 361:249-66. 1995..phosphate diaphorase (NADPH-d), neuron-specific enolase (NSE)], glial markers [RC-2, vimentin, glial fibrillary acidic protein (GFAP), galactocerebroside (Gal-C)], ECM markers [tenascin-C (TN-C), chondroitin sulfate, a ..
- GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelinationW Liedtke
Department of Pathology Division of Neuropathology, Albert Einstein College of Medicine, Bronx, New York 10016, USA
Neuron 17:607-15. 1996To investigate the structural role of glial fibrillary acidic protein (GFAP) in vivo, mice carrying a null mutation in GFAP were generated...
- Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1J Galceran
Howard Hughes Medical Institute, Department of Microbiology, University of California, San Francisco, CA 94143, USA
Development 127:469-82. 2000..Thus, LEF1 regulates the generation of dentate gyrus granule cells, and together with other LEF1/TCF proteins, the development of the hippocampus...
- Cortical axon guidance by the glial wedge during the development of the corpus callosumT Shu
The University of Maryland, Baltimore, School of Medicine, Department of Anatomy and Neurobiology, and the Program in Neuroscience, Baltimore, Maryland 21201, USA
J Neurosci 21:2749-58. 2001..Furthermore, slit-2 repels-suppresses cortical axon growth in three-dimensional collagen gel cocultures...
- A 1.8kb GFAP-promoter fragment is active in specific regions of the embryonic CNSJ Andrae
Department of Genetics and Pathology, Rudbeck Laboratory, University Hospital, Uppsala University, SE 751 85 Uppsala, Sweden
Mech Dev 107:181-5. 2001The intermediate filament glial fibrillary acidic protein (GFAP) constitutes the major cytoskeletal protein in astrocytes (J. Neuroimmunol. 8 (1985) 203) and is traditionally referred to as a specific marker for astrocytes...
- Fgfr3 expression by astrocytes and their precursors: evidence that astrocytes and oligodendrocytes originate in distinct neuroepithelial domainsNigel P Pringle
Wolfson Institute for Biomedical Research and Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
Development 130:93-102. 2003..Many glial fibrillary acidic protein (Gfap)- positive astrocytes co-express Fgfr3 in vitro and in vivo...
- GFAP knockout mice have increased levels of GDNF that protect striatal neurons from metabolic and excitotoxic insultsRose Hanbury
Research Center for Brain Repair and Department of Neurological Sciences, Rush Presbyterian Medical Center, Chicago, Illinois 60612, USA
J Comp Neurol 461:307-16. 2003..to injury and degeneration, astrocytes hypertrophy, extend processes, and increase production of glial fibrillary acidic protein (GFAP), an intermediate filament protein located within their cytoplasm...
- Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brainAnna L M Ferri
Department of Biotechnology and Biosciences, University of Milano Bicocca, Piazza della Scienza 2, 20126 Milano, Italy
Development 131:3805-19. 2004..cell proliferation and the generation of new neurones in adult neurogenic regions are greatly decreased, and GFAP/nestin-positive hippocampal cells, which include the earliest neurogenic precursors, are strikingly diminished...
- Re-establishing the regenerative potential of central nervous system axons in postnatal miceKin Sang Cho
Schepens Eye Research Institute, Program in Neuroscience and Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
J Cell Sci 118:863-72. 2005..These results suggest that an early postnatal downregulation of Bcl-2 and post-traumatic reactive gliosis are two important elements of axon regenerative failure in the CNS...
- Doublecortin-like kinase functions with doublecortin to mediate fiber tract decussation and neuronal migrationHiroyuki Koizumi
Neurogenetics Laboratory, Department of Neurosciences, University of California, San Diego, La Jolla, California 93093, USA
Neuron 49:55-66. 2006..Surprisingly, RNAi-mediated knockdown of either gene results in similar migration defects. These results indicate the Dcx microtubule-associated protein family is required for proper neuronal migration and axonal wiring...
- Loss of glial fibrillary acidic protein (GFAP) impairs Schwann cell proliferation and delays nerve regeneration after damageDaniela Triolo
Neuropathology Unit, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
J Cell Sci 119:3981-93. 2006..We investigated whether peripheral nerve regeneration is perturbed in mice that lack glial fibrillary acidic protein (GFAP), a Schwann-cell-specific cytoskeleton constituent upregulated after damage...
- Synergistic effects of the SAPK/JNK and the proteasome pathway on glial fibrillary acidic protein (GFAP) accumulation in Alexander diseaseGuomei Tang
Department of Pathology and the Center for Neurobiology and Behavior, Columbia University, 630 W 168th Street, New York, NY 10032, USA
J Biol Chem 281:38634-43. 2006Protein aggregates in astrocytes that contain glial fibrillary acidic protein (GFAP), small heat shock proteins, and ubiquitinated proteins are termed Rosenthal fibers and characterize Alexander disease, a leukodystrophy caused by ..
- Thrombospondin-4 and matrix three-dimensionality in axon outgrowth and adhesion in the developing retinaErin Tolhurst Dunkle
Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA 93106, USA
Exp Eye Res 84:707-17. 2007..These results support a model where TSP-4 acts as an organizer of adhesive and axon outgrowth-promoting molecules in the ECM to optimize retinal ganglion cell responses...
- Synemin is expressed in reactive astrocytes in neurotrauma and interacts differentially with vimentin and GFAP intermediate filament networksRunfeng Jing
Department of Cellular Biology and Anatomy and Feist Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
J Cell Sci 120:1267-77. 2007..astrocytes and astrocytoma cells contain synemin and three other intermediate filament (IF) proteins: glial fibrillary acidic protein (GFAP), vimentin and nestin...
- Live imaging of neuroinflammation reveals sex and estrogen effects on astrocyte response to ischemic injuryPierre Cordeau
Department of Anatomy and Physiology, Universite Laval, Quebec, Canada
Stroke 39:935-42. 2008..We sought to develop a model system for live analysis of brain inflammatory response in ischemic injury...
- Neurogenin 2 has an essential role in development of the dentate gyrusChristophe Galichet
Division of Molecular Neurobiology, National Institute of Medical Research, The Ridgeway, Mill Hill, NW7 1AA London, UK
Development 135:2031-41. 2008..These data establish a unique role of Ngn2 in DG neurogenesis during development and raise the possibility that Ngn2 has a similar function in adult neurogenesis...
- Identification of positionally distinct astrocyte subtypes whose identities are specified by a homeodomain codeChristian Hochstim
Division of Biology 216 76, Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA
Cell 133:510-22. 2008....
- Specific glial populations regulate hippocampal morphogenesisGuy Barry
The University of Queensland, Queensland Brain Institute, and School of Biomedical Sciences, Brisbane, 4067, Australia
J Neurosci 28:12328-40. 2008..However, these fail to mature into GLAST- and GFAP-positive glia, and the supragranular glial bundle is absent...
- Properties of astrocytes cultured from GFAP over-expressing and GFAP mutant miceWoosung Cho
Waisman Center, Department of Comparative Biosciences, University of Wisconsin Madison, Madison, WI 53705, USA
Exp Cell Res 315:1260-72. 2009Alexander disease is a fatal leukoencephalopathy caused by dominantly-acting coding mutations in GFAP. Previous work has also implicated elevations in absolute levels of GFAP as central to the pathogenesis of the disease...
- A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated agingMatilde Murga
Genomic Instability Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
Nat Genet 41:891-8. 2009....
- GFAPdelta in radial glia and subventricular zone progenitors in the developing human cortexJinte Middeldorp
Department of Astrocyte Biology and Neurodegeneration, Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands
Development 137:313-21. 2010A subpopulation of glial fibrillary acidic protein (GFAP)-expressing cells located along the length of the lateral ventricles in the subventricular zone (SVZ) have been identified as the multipotent neural stem cells of the adult ..
- Vimentin and GFAP responses in astrocytes after contusion trauma to the murine brainSara Ekmark-Lewén
Department of Neuroscience, Neurosurgery, Uppsala University, Uppsala University Hospital, Uppsala, Sweden
Restor Neurol Neurosci 28:311-21. 2010..The aims for this study were to compare the temporal and spatial expression pattern of vimentin- and glial fibrillary acidic protein (GFAP) in a weight drop model of mild cerebral contusion injury in the rat...
- Intermediate filaments attenuate stimulation-dependent mobility of endosomes/lysosomes in astrocytesMaja Potokar
Celica Biomedical Center, Ljubljana, Slovenia
Glia 58:1208-19. 2010..of labeled vesicles in astrocytes, derived from either wild-type (WT) mice or mice deficient in glial fibrillary acidic protein and vimentin (GFAP(-/-)Vim(-/-)), the latter lacking astrocyte IFs...
- Prox1 is required for granule cell maturation and intermediate progenitor maintenance during brain neurogenesisAlfonso Lavado
Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
PLoS Biol 8:. 2010..Finally, we show that the ectopic expression of Prox1 induces premature differentiation of neural stem cells...
- Prox1 regulates the notch1-mediated inhibition of neurogenesisValeria Kaltezioti
Center for Basic Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
PLoS Biol 8:e1000565. 2010..Together these data suggest that Prox1 inhibits Notch1 gene expression to control the balance between NPC self-renewal and neuronal differentiation...
- Sprouty genes prevent excessive FGF signalling in multiple cell types throughout development of the cerebellumTian Yu
Department of Craniofacial Development, King s College London, London, UK
Development 138:2957-68. 2011..Taken together, our data demonstrate that FGF signalling levels have to be tightly controlled throughout cerebellar development in order to maintain the normal development of multiple cell types...
- Postnatal loss of Dlk1 imprinting in stem cells and niche astrocytes regulates neurogenesisSacri R Ferron
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK
Nature 475:381-5. 2011....
- Beneficial effects of Nrf2 overexpression in a mouse model of Alexander diseaseChristine M Lapash Daniels
Waisman Center, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
J Neurosci 32:10507-15. 2012Alexander disease is a fatal neurodegenerative disease caused by dominant mutations in glial fibrillary acidic protein (GFAP)...
- GFAP isoforms in adult mouse brain with a focus on neurogenic astrocytes and reactive astrogliosis in mouse models of Alzheimer diseaseWillem Kamphuis
Netherlands Institute for Neuroscience an Institute of the Royal Netherlands Academy of Arts and Sciences, Department of Astrocyte Biology and Neurodegeneration, Amsterdam, The Netherlands
PLoS ONE 7:e42823. 2012b>Glial fibrillary acidic protein (GFAP) is the main astrocytic intermediate filament (IF). GFAP splice isoforms show differential expression patterns in the human brain...
- GFAPδ expression in glia of the developmental and adolescent mouse brainCarlyn Mamber
Department of Astrocyte Biology and Neurodegeneration, Netherlands Institute for Neuroscience Institute of the Royal Netherlands Academy of Arts and Sciences KNAW, Amsterdam, The Netherlands
PLoS ONE 7:e52659. 2012b>Glial fibrillary acidic protein (GFAP) is the major intermediate filament (IF) protein in astrocytes. In the human brain, GFAP isoforms have unique expression patterns, which indicate that they play distinct functional roles...
- Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal deathC B Ware
Immunex, Seattle, WA 98101, USA
Development 121:1283-99. 1995..Hematologic and primordial germ cell compartments appear normal. Pleiotropic defects in the mutant animals preclude survival beyond the day of birth...
- The expression pattern of a novel gene encoding brain-fatty acid binding protein correlates with neuronal and glial cell developmentA Kurtz
Unit on Developmental Biology, National Institute of Mental Health, Bethesda, MD 20892
Development 120:2637-49. 1994....
- Brain lipid-binding protein (BLBP): a novel signaling system in the developing mammalian CNSL Feng
Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021
Neuron 12:895-908. 1994..Based on these results, we propose that BLBP is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers...
- Deficient cerebellar long-term depression, impaired eyeblink conditioning, and normal motor coordination in GFAP mutant miceK Shibuki
Institute for Virus Research, Kyoto University, Syogo in, Sakyo ku, Japan
Neuron 16:587-99. 1996Mice devoid of glial fibrillary acidic protein (GFAP), an intermediate filament protein specifically expressed in astrocytes, develop normally and do not show any detectable abnormalities in the anatomy of the brain...
- Experimental autoimmune encephalomyelitis in mice lacking glial fibrillary acidic protein is characterized by a more severe clinical course and an infiltrative central nervous system lesionW Liedtke
Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
Am J Pathol 152:251-9. 1998Insights into the role of the astrocyte intermediate filament protein, glial fibrillary acidic protein (GFAP), have only recently emerged with reports on subtle abnormalities in GFAP-deficient mice, including the documentation of ..
- Mice lacking GFAP are hypersensitive to traumatic cerebrospinal injuryH Nawashiro
Stroke Branch, NINDS, NIH, Bethesda, MD 20892 4128, USA
Neuroreport 9:1691-6. 1998b>Glial fibrillary acidic protein (GFAP) is an intermediate filament protein expressed primarily in astrocytes...
- Tbr1 regulates differentiation of the preplate and layer 6R F Hevner
Nina Ireland Laboratory of, Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94143, USA
Neuron 29:353-66. 2001..These results show that Tbr1 is a common genetic determinant for the differentiation of early-born glutamatergic neocortical neurons and provide insights into the functions of these neurons as regulators of cortical development...
- Beta1-class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortexD Graus-Porta
Friedrich Miescher Institute, Maulbeerstr 66, 4058, Basel, Switzerland
Neuron 31:367-79. 2001..The phenotype of the beta1-deficient mice resembles pathological changes observed in human cortical dysplasias, suggesting that defective integrin-mediated signal transduction contributes to the development of some of these diseases...
- Control of oligodendrocyte differentiation by the Nkx2.2 homeodomain transcription factorY Qi
Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, KY 40292, USA
Development 128:2723-33. 2001..Consistent with this suggestion, overproduction of Nkx2.2 protein in fibroblast cells can induce gene expression from the proteolipid protein promoter...
- Intermediate filaments regulate astrocyte motilityE A Lepekhin
Protein Laboratory, Institute of Molecular Pathology, University of Copenhagen, Copenhagen, Denmark
J Neurochem 79:617-25. 2001..that glial scar formation following brain or spinal cord injury is impaired in mice deficient in glial fibrillary acidic protein and vimentin...
- Abnormal development of forebrain midline glia and commissural projections in Nfia knock-out miceTianzhi Shu
Department of Anatomy and Neurobiology, and the Program in Neuroscience, The University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA
J Neurosci 23:203-12. 2003..1997). Disruption of the Nfia gene causes agenesis of the corpus callosum (ACC), hydrocephalus, and reduced GFAP expression (das Neves et al., 1999)...
- The glial sling is a migratory population of developing neuronsTianzhi Shu
The University of Maryland, Baltimore, School of Medicine, Department of Anatomy and Neurobiology, and the Program in Neuroscience, 685 West Baltimore Street, Baltimore, MD 21201, USA
Development 130:2929-37. 2003..These data indicate that the sling may be a source of, or migratory pathway for, developing neurons in the rostral forebrain, suggesting additional functions for the sling independent of callosal axon guidance...
- Genetic polymorphism and sequence evolution of an alternatively spliced exon of the glial fibrillary acidic protein gene, GFAPRipudaman Singh
Institute of Human Genetics, University of Aarhus, DK 8000 Aarhus C, Denmark
Genomics 82:185-93. 2003Isoform GFAPepsilon of the human cytoskeletal protein GFAP carries, as the result of alternative splicing of exon 7a of GFAP, a novel 42-amino-acid-long C-terminal region with binding capacity for the presenilin proteins...
- IR-INDUCED APOPTOSIS IN THE DEVELOPING NERVOUS SYSTEMPETER MCKINNON; Fiscal Year: 2004..Moreover, as neurodegenerative disease may engage similar apoptotic pathways, the findings from this proposal will be relevant for understanding neuronal death in neurodegenerative disease. ..
- ATM and DNA Damage in the Nervous SystemPETER MCKINNON; Fiscal Year: 2007..abstract_text> ..
- NEURONAL MIGRATION IN THE DEVELOPING BRAINHuaiyu Hu; Fiscal Year: 2003....
- Molecular Studies of Brain MalformationsHuaiyu Hu; Fiscal Year: 2007....
- The Role of Id2 in Adult NeurogenesisMATTHEW HAVRDA; Fiscal Year: 2008..These experiments are immediately relevant to realization of the therapeutic potential of these unique cells. [unreadable] [unreadable]..
- Cell migration and differentiation in the olfactory bulbAdam Puche; Fiscal Year: 2004..Understand the mechanisms of SVZ progenitor migration through the olfactory bulb and cues governing phenotype selection have important implications for the use of these cells as clinical therapy. ..
- RNAi-mediated Silencing of Mutant Superoxide DismutaseMICHELE MAXWELL; Fiscal Year: 2006..In addition, the therapeutic potential of RNAi will be assessed using viral delivery of shRNA to the spinal cords of mutant SOD1 transgenic mice. ..
- Alcohol Modulation of Cerebellar Synaptic CurrentsWilliam Proctor; Fiscal Year: 2006..The combination of our proposed and ongoing genetic studies may aid the identification of more sensitive drug targets and the development of novel drugs for rational therapeutic approaches to alcoholism. ..
- DNA methylation in Neuronal and Glial DifferentiationGuoping Fan; Fiscal Year: 2007..The proposed study may provide fundamental insights into the role of DNA methylation in neural development as well as the disease mechanism underlying certain mental retardation disorders. ..
- Varenicline and Smoking Cessation in SchizophreniaSEYYED HOSSEIN FATEMI; Fiscal Year: 2010..Such outcomes will be significant, because they will offer a new treatment for smoking cessation in this vulnerable population. ..
- Prenatal Virally Induced Brain Disorder in MouseSEYYED FATEMI; Fiscal Year: 2009..In addition, it is expected that the results will provide clues that will lead to fundamental advances in our knowledge of the pathogenesis of schizophrenia and, therefore, of how it can be prevented and treated. ..