Gja1

Summary

Gene Symbol: Gja1
Description: gap junction protein, alpha 1
Alias: AU042049, AW546267, Cnx43, Cx43, Cx43alpha1, Gja-1, Npm1, connexin43, gap junction alpha-1 protein, alpha 1 connexin, connexin-43, gap junction 43 kDa heart protein, gap junction membrane channel protein alpha 1
Species: mouse

Top Publications

  1. pmc Connexin43 deficiency causes delayed ossification, craniofacial abnormalities, and osteoblast dysfunction
    F Lecanda
    Divisions of Bone and Mineral and Infectious Diseases, Department of Internal Medicine, Washington University School of Medicine, Barnes Jewish Hospital, St Louis, Missouri 63110, USA
    J Cell Biol 151:931-44. 2000
  2. ncbi Failure of spermatogenesis in mice lacking connexin43
    W A Roscoe
    Department of Physiology, The University of Western Ontario, London, Ontario, Canada N6A 5C1
    Biol Reprod 65:829-38. 2001
  3. doi Presence of connexin 43 in subsarcolemmal, but not in interfibrillar cardiomyocyte mitochondria
    Kerstin Boengler
    Institut fur Pathophysiologie, Zentrum fur Innere Medizin, Universitatsklinikum Essen, Essen, Germany
    Basic Res Cardiol 104:141-7. 2009
  4. pmc Cell autonomous requirement of connexin 43 for osteocyte survival: consequences for endocortical resorption and periosteal bone formation
    Nicoletta Bivi
    Department Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202 5120, USA
    J Bone Miner Res 27:374-89. 2012
  5. ncbi Cx43 gap junction gene expression and gap junctional communication in mouse neural crest cells
    C W Lo
    Biology Department, University of Pennsylvania, Philadelphia, USA
    Dev Genet 20:119-32. 1997
  6. ncbi Comparison of connexin expression patterns in the developing mouse heart and human foetal heart
    Steven R Coppen
    Cardiac Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College, Royal Brompton Hospital, London, UK
    Mol Cell Biochem 242:121-7. 2003
  7. ncbi Acute downregulation of connexin43 at wound sites leads to a reduced inflammatory response, enhanced keratinocyte proliferation and wound fibroblast migration
    Ryoichi Mori
    Department of Physiology, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
    J Cell Sci 119:5193-203. 2006
  8. doi Involvement of the cytoplasmic C-terminal domain of connexin43 in neuronal migration
    Cima Cina
    Department of Cellular and Physiological Sciences, The Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z3
    J Neurosci 29:2009-21. 2009
  9. pmc Slow ventricular conduction in mice heterozygous for a connexin43 null mutation
    P A Guerrero
    Department of Medicine, Washington University, St Louis, Missouri 63110, USA
    J Clin Invest 99:1991-8. 1997
  10. ncbi Defects in the germ line and gonads of mice lacking connexin43
    S C Juneja
    Department of Physiology, The University of Manitoba, Winnipeg, Manitoba, Canada R3E 3J7
    Biol Reprod 60:1263-70. 1999

Detail Information

Publications177 found, 100 shown here

  1. pmc Connexin43 deficiency causes delayed ossification, craniofacial abnormalities, and osteoblast dysfunction
    F Lecanda
    Divisions of Bone and Mineral and Infectious Diseases, Department of Internal Medicine, Washington University School of Medicine, Barnes Jewish Hospital, St Louis, Missouri 63110, USA
    J Cell Biol 151:931-44. 2000
    ..We have shown that overexpression of Cx45 in osteoblasts expressing endogenous Cx43 leads to decreased cell-cell communication (Koval, M., S.T. Geist, E.M. Westphale, A.E. Kemendy, R. Civitelli, E.C...
  2. ncbi Failure of spermatogenesis in mice lacking connexin43
    W A Roscoe
    Department of Physiology, The University of Western Ontario, London, Ontario, Canada N6A 5C1
    Biol Reprod 65:829-38. 2001
    b>Connexin43 (Cx43), a gap junction protein encoded by the Gja1 gene, is expressed in several cell types of the testis...
  3. doi Presence of connexin 43 in subsarcolemmal, but not in interfibrillar cardiomyocyte mitochondria
    Kerstin Boengler
    Institut fur Pathophysiologie, Zentrum fur Innere Medizin, Universitatsklinikum Essen, Essen, Germany
    Basic Res Cardiol 104:141-7. 2009
    ..b>Connexin 43 (Cx43) is located at the inner membrane of SSM, and Cx43 is involved in the cardioprotection by ischemic ..
  4. pmc Cell autonomous requirement of connexin 43 for osteocyte survival: consequences for endocortical resorption and periosteal bone formation
    Nicoletta Bivi
    Department Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202 5120, USA
    J Bone Miner Res 27:374-89. 2012
    b>Connexin 43 (Cx43) mediates osteocyte communication with other cells and with the extracellular milieu and regulates osteoblastic cell signaling and gene expression...
  5. ncbi Cx43 gap junction gene expression and gap junctional communication in mouse neural crest cells
    C W Lo
    Biology Department, University of Pennsylvania, Philadelphia, USA
    Dev Genet 20:119-32. 1997
    ..known to be important in mediating cell-cell interactions amongst migratory cells, our studies showed that the connexin 43 (Cx43) gap junction gene is widely expressed in mouse neural crest cell lineages...
  6. ncbi Comparison of connexin expression patterns in the developing mouse heart and human foetal heart
    Steven R Coppen
    Cardiac Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College, Royal Brompton Hospital, London, UK
    Mol Cell Biochem 242:121-7. 2003
    ..The expression of the three major connexins (Cx43, Cx40 and Cx45) present in cardiac myocytes is known to be developmentally regulated but it is not clear how the ..
  7. ncbi Acute downregulation of connexin43 at wound sites leads to a reduced inflammatory response, enhanced keratinocyte proliferation and wound fibroblast migration
    Ryoichi Mori
    Department of Physiology, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
    J Cell Sci 119:5193-203. 2006
    Experimental downregulation of connexin43 (Cx43) expression at skin wound sites appears to markedly improve the rate and quality of healing, but the underlying mechanisms are currently unknown...
  8. doi Involvement of the cytoplasmic C-terminal domain of connexin43 in neuronal migration
    Cima Cina
    Department of Cellular and Physiological Sciences, The Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z3
    J Neurosci 29:2009-21. 2009
    ..we used Cre recombinase, driven by the nestin promoter, to conditionally knock-out a floxed coding DNA of the connexin43 (Cx43) gene in mice. Radial glia in the VZ normally express connexin43...
  9. pmc Slow ventricular conduction in mice heterozygous for a connexin43 null mutation
    P A Guerrero
    Department of Medicine, Washington University, St Louis, Missouri 63110, USA
    J Clin Invest 99:1991-8. 1997
    To characterize the role of the gap junction protein connexin43 (Cx43) in ventricular conduction, we studied hearts of mice with targeted deletion of the Cx43 gene...
  10. ncbi Defects in the germ line and gonads of mice lacking connexin43
    S C Juneja
    Department of Physiology, The University of Manitoba, Winnipeg, Manitoba, Canada R3E 3J7
    Biol Reprod 60:1263-70. 1999
    ..Numerous connexins, including connexin43 (Cx43), have been implicated in reproductive processes by virtue of their expression in adult gonads...
  11. ncbi An update on connexin genes and their nomenclature in mouse and man
    Goran Sohl
    Institut fur Genetik, Universitat Bonn, Germany
    Cell Commun Adhes 10:173-80. 2003
    ..Furthermore, this short review contains an update on phenotypic correlations between connexin deficient mice and patients bearing mutations in their orthologous connexin genes...
  12. ncbi The transcriptional repressor Tbx3 delineates the developing central conduction system of the heart
    Willem M H Hoogaars
    Experimental and Molecular Cardiology Group, AMC, University of Amsterdam, Amsterdam, The Netherlands
    Cardiovasc Res 62:489-99. 2004
    ..We studied the developmental expression pattern and functional aspects of the T-box transcription factor Tbx3, a novel marker for the murine central conduction system (CCS)...
  13. ncbi A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia
    Ann M Flenniken
    Centre for Modeling Human Disease, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    Development 132:4375-86. 2005
    ..that was shown recently to be caused by mutations in the gap junction protein alpha 1 gene (GJA1), encoding connexin 43 (Cx43)...
  14. pmc A sertoli cell-specific knockout of connexin43 prevents initiation of spermatogenesis
    Ralph Brehm
    Justus Liebig Universitaet, Institut fuer Veterinaer Anatomie, Histologie, und Embryologie, Frankfurter Strasse 98, Giessen, Germany
    Am J Pathol 171:19-31. 2007
    The predominant testicular gap junctional protein connexin43 (cx43) is located between neighboring Sertoli cells (SCs) and between SCs and germ cells...
  15. ncbi Regulation of connexin43-protein binding in astrocytes in response to chemical ischemia/hypoxia
    Wei Li
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 280:7941-8. 2005
    ..We have primarily used immunoprecipitation strategies to investigate whether connexin43 binds to selected signaling and cytoskeletal proteins and whether connexin43-protein binding is altered in ..
  16. ncbi Proliferation of adult sertoli cells following conditional knockout of the Gap junctional protein GJA1 (connexin 43) in mice
    Santhi Sridharan
    Department of Veterinary Biosciences, University of Illinois at Urbana Champaign, Urbana, Illinois 61802, USA
    Biol Reprod 76:804-12. 2007
    GJA1 (also known and referred to here as connexin 43 and abbreviated CX43) is the predominant testicular gap junction protein, and CX43 may regulate Sertoli cell maturation and spermatogenesis...
  17. pmc Mitochondrial connexin 43 impacts on respiratory complex I activity and mitochondrial oxygen consumption
    Kerstin Boengler
    Institut fur Pathophysiologie, Universitatsklinikum Essen, Essen, Germany
    J Cell Mol Med 16:1649-55. 2012
    b>Connexin 43 (Cx43) is present at the sarcolemma and the inner membrane of cardiomyocyte subsarcolemmal mitochondria (SSM)...
  18. ncbi Low peak bone mass and attenuated anabolic response to parathyroid hormone in mice with an osteoblast-specific deletion of connexin43
    Dong Jin Chung
    Division of Bone and Mineral Diseases, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    J Cell Sci 119:4187-98. 2006
    b>Connexin43 (Cx43) is involved in bone development, but its role in adult bone homeostasis remains unknown...
  19. ncbi T-box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers
    Vincent M Christoffels
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Dev Dyn 229:763-70. 2004
    ..expression in mouse hearts was found to be complementary to that of chamber myocardium-specific genes Nppa, Cx40, Cx43, and Chisel, and was conserved in human...
  20. ncbi Connexin43 gene expression and regulation in the rodent seminiferous epithelium
    C Batias
    INSERM CJF 95 04, EA 1760, IFR 50, Faculte de Medecine, Nice, France
    J Histochem Cytochem 48:793-805. 2000
    b>Connexin43 (Cx43) is one of the most predominant gap junction proteins found in the testis...
  21. pmc Expression of Gja1 correlates with the phenotype observed in oculodentodigital syndrome/type III syndactyly
    R Richardson
    J Med Genet 41:60-7. 2004
  22. ncbi Analysis of multiple gap junction gene products in the rodent and human mammary gland
    A Pozzi
    Department of Cell Biology, Scripps Research Institute, La Jolla, California 92037, USA
    Exp Cell Res 220:212-9. 1995
    ..RT-PCR amplification revealed a constitutive expression of RNA for alpha 1 connexin in all three species...
  23. ncbi Heart defects in connexin43-deficient mice
    J Ya
    Department of Anatomy and Embryology, Academic Medical Center, University of Amsterdam, The Netherlands
    Circ Res 82:360-6. 1998
    Cardiac malformation in connexin43 (CX43)-disrupted mice is restricted to the junction between right ventricle and outflow tract, even though CX43 is also expressed abundantly elsewhere...
  24. ncbi Chamber formation and morphogenesis in the developing mammalian heart
    V M Christoffels
    Department of Anatomy and Embryology, Academic Medical Center, University of Amsterdam, Amsterdam, 1105, The Netherlands
    Dev Biol 223:266-78. 2000
    ....
  25. ncbi Unique and shared functions of different connexins in mice
    A Plum
    Institut fur Genetik, Universitat Bonn, Roemerstrasse164, D 53117, Bonn, Germany
    Curr Biol 10:1083-91. 2000
    ..Mice lacking connexin43 (Cx43) die postnatally from obstruction of the right ventricular outflow tract of the heart...
  26. ncbi General and conditional replacement of connexin43-coding DNA by a lacZ reporter gene for cell-autonomous analysis of expression
    M Theis
    Institut fur Genetik, Abteilung Molekulargenetik, Universitat Bonn, Germany
    Cell Commun Adhes 8:383-6. 2001
    ..possible pleiotropic effects of general Cx43 gene deletion, in order to determine the expression and function of connexin43 (Cx43) in defined cell types. General or cell type-specific, Cre-mediated deletion of the floxed (i.e...
  27. ncbi Altered connexin expression and wound healing in the epidermis of connexin-deficient mice
    Markus Kretz
    Institut fur Genetik, Abteilung Molekulargenetik Römerstrasse 164, 53117 Bonn, Germany
    J Cell Sci 116:3443-52. 2003
    ..transgenic mouse mutants: connexin30-/-, connexin31-/- and connexin43Cre-ER(T)/fl (for inducible deletion of the connexin43 coding region)...
  28. ncbi Patch-clamp study reveals that the importance of connexin43-mediated gap junctional communication for ovarian folliculogenesis is strain specific in the mouse
    Dan Tong
    Dept of Physiology and Pharmacology, The Univ of Western Ontario, Dental Science Bldg, Rm 00073, London, ON, Canada N6A 5C1
    Am J Physiol Cell Physiol 290:C290-7. 2006
    Genetic ablation of connexin37 (Cx37) or connexin43 (Cx43), the two gap junction proteins expressed by mouse ovarian granulosa cells, has been shown to result in impaired follicle development...
  29. pmc Characterization of Bves expression during mouse development using newly generated immunoreagents
    Travis K Smith
    The Stahlman Cardiovascular Research Laboratories, Program for Developmental Biology, and Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6300, USA
    Dev Dyn 235:1701-8. 2006
    ....
  30. ncbi ATP release from activated neutrophils occurs via connexin 43 and modulates adenosine-dependent endothelial cell function
    Holger K Eltzschig
    Department of Anesthesiology and Intensive Care Medicine, Tubingen University Hospital, Germany
    Circ Res 99:1100-8. 2006
    ..These studies showed that PMN ATP release occurs through connexin 43 (Cx43) hemichannels in a protein/phosphatase-A-dependent manner...
  31. doi The connexin43 C-terminal region mediates neuroprotection during stroke
    Michael G Kozoriz
    Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Canada
    J Neuropathol Exp Neurol 69:196-206. 2010
    b>Connexin43 plays an important role in neuroprotection in experimental stroke models; reducing the expression of this gap junction protein in astrocytes enhances injury upon middle cerebral artery occlusion (MCAO)...
  32. doi Milk secretion and ejection are impaired in the mammary gland of mice harboring a Cx43 mutant while expression and localization of tight and adherens junction proteins remain unchanged
    Isabelle Plante
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada
    Biol Reprod 82:837-47. 2010
    ..mammary glands from Gja1(Jrt/+) mice, harboring a mutation in the Gja1 gene encoding connexin (Cx) 43, have reduced Cx43 gap junction function and are unable to release milk to the pups...
  33. pmc Characterization of hTERT-immortalized osteoblast cell lines generated from wild-type and connexin43-null mouse calvaria
    Mia M Thi
    Department of Orthopaedic Surgery, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA
    Am J Physiol Cell Physiol 299:C994-C1006. 2010
    The gap junction protein connexin43 (Cx43) has been proposed to play key roles in bone differentiation and mineralization, but underlying cellular mechanisms are not totally understood...
  34. ncbi Establishment of cardiac cytoarchitecture in the developing mouse heart
    Alain Hirschy
    Institute of Cell Biology, ETH Zurich Honggerberg, CH 8093 Zurich, Switzerland
    Dev Biol 289:430-41. 2006
    ..These observations help to understand the mechanisms that lead to the formation of a functional heart during development at a cellular level...
  35. pmc Influence of natriuretic peptide receptor-1 on survival and cardiac hypertrophy during development
    Nicola J A Scott
    Department of Medicine, University of Otago Christchurch, P O Box 4345, Christchurch, New Zealand
    Biochim Biophys Acta 1792:1175-84. 2009
    ..However, there was a significant decrease in Connexin-43 (Cx43) gene and protein expression at mid-gestation in Npr1(-/-)embryos...
  36. doi Neuregulin 1 sustains the gene regulatory network in both trabecular and nontrabecular myocardium
    Donna Lai
    Victor Chang Cardiac Research Institute, Lowy Packer Building, 405 Liverpool St, Darlinghurst 2010, Australia
    Circ Res 107:715-27. 2010
    ..In development, the membrane-tethered signaling ligand Neuregulin (Nrg)1, expressed in endocardium, is essential for ventricular morphogenesis. In adults, Nrg1 protects against heart failure and can induce cardiomyocytes to divide...
  37. ncbi High resolution optical mapping reveals conduction slowing in connexin43 deficient mice
    B C Eloff
    The Heart and Vascular Research Center, MetroHealth Campus, Case Western Reserve University, 2500 MetroHealth Drive, Hamman 322, Cleveland, OH 44109 1998, USA
    Cardiovasc Res 51:681-90. 2001
    ..However, conflicting results have been reported regarding conduction velocity slowing in mice heterozygous for a null mutation in the gene encoding connexin43 (Cx43).
  38. pmc Impulse propagation in synthetic strands of neonatal cardiac myocytes with genetically reduced levels of connexin43
    Stuart P Thomas
    Department of Physiology, University of Bern, Bühlplatz5, CH 3012 Bern, Switzerland
    Circ Res 92:1209-16. 2003
    b>Connexin43 (Cx43) is a major determinant of the electrical properties of the myocardium...
  39. pmc Modulation of cardiac gap junction expression and arrhythmic susceptibility
    Stephan B Danik
    The Leon H Charney Division of Cardiology, New York University School of Medicine, New York 10010, USA
    Circ Res 95:1035-41. 2004
    b>Connexin43 (Cx43), the predominant ventricular gap junction protein, is critical for maintaining normal cardiac electrical conduction, and its absence in the mouse heart results in sudden arrhythmic death...
  40. pmc Adhesive properties of connexin hemichannels
    M L Cotrina
    Department of Neurosurgery, Division of Glial Disease and Therapeutics, University of Rochester Medical Center, Rochester, New York 14642, USA
    Glia 56:1791-8. 2008
    ..We have also found that high expression of Cx43, but not Cx32 hemichannels, can drive adhesion of cells expressing low levels of Cx43...
  41. pmc Connexin 43 is required for the anti-apoptotic effect of bisphosphonates on osteocytes and osteoblasts in vivo
    Lilian I Plotkin
    Division of Endocrinology and Metabolism, the Center for Osteoporosis and Metabolic Bone Diseases, The Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA
    J Bone Miner Res 23:1712-21. 2008
    ..Herein, we evaluated its requirement for the in vivo actions of bisphosphonates using mice in which Cx43 was deleted specifically from osteocytes and osteoblasts (Cx43(DeltaOb-Ot/-) mice)...
  42. pmc Attenuated response to in vivo mechanical loading in mice with conditional osteoblast ablation of the connexin43 gene (Gja1)
    Susan K Grimston
    Division of Bone and Mineral Disease, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Bone Miner Res 23:879-86. 2008
    In vitro data suggest that gap junctional intercellular communication mediated by connexin43 (Cx43) plays an important role in bone cell response to mechanical stimulation...
  43. ncbi Spatial and temporal patterns of distribution of the gap junction protein connexin43 during mouse gastrulation and organogenesis
    S B Yancey
    Division of Biology, California Institute of Technology, Pasadena 91125
    Development 114:203-12. 1992
    b>Connexin43 (Cx43) is a member of the family of channel-forming proteins that make up the gap junction and are believed to provide pathways for cell-cell exchange of developmental signals...
  44. ncbi Alteration in connexin 43 gap junction gene dosage impairs conotruncal heart development
    G Y Huang
    Department of Biology, Goddard Laboratory, University of Pennsylvania, Philadelphia 19104, USA
    Dev Biol 198:32-44. 1998
    b>Connexin 43 (Cx43) knockout mice and transgenic mice (CMV43) overexpressing the Cx43 gap junction gene exhibit heart defects involving the conotruncus and right ventricle...
  45. ncbi Voltage-gated Na+ channel activity and connexin expression in Cx43-deficient cardiac myocytes
    C M Johnson
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cardiovasc Electrophysiol 10:1390-401. 1999
    ..Mice with targeted disruption of the connexin43 (Cx43) gene have hearts completely devoid of Cx43, the principal gap junctional protein expressed in mammalian ..
  46. ncbi Endothelium-specific replacement of the connexin43 coding region by a lacZ reporter gene
    M Theis
    Institut fur Genetik, Universitat Bonn, Bonn, Germany
    Genesis 29:1-13. 2001
    The murine gap junction protein connexin43 (Cx43) is expressed in blood vessels, with vastly different contribution by endothelial and smooth muscle cells...
  47. ncbi Intercellular communication via connexin43 gap junctions is required for ovarian folliculogenesis in the mouse
    C L Ackert
    Department of Physiology, The University of Western Ontario, London, Ontario N6A 5C1, Canada
    Dev Biol 233:258-70. 2001
    ..b>Connexin43 immunoreactivity can be detected from the onset of folliculogenesis just after birth and persists through ..
  48. ncbi Connexin family members target to lipid raft domains and interact with caveolin-1
    Anne Lane Schubert
    Department of Molecular Pharmacology and Albert Einstein Cancer Center and Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Biochemistry 41:5754-64. 2002
    ..We show that connexin 43 (Cx43) colocalizes, cofractionates, and coimmunoprecipitates with caveolin-1...
  49. ncbi Proliferation, differentiation and apoptosis in connexin43-null osteoblasts
    F Furlan
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Cell Commun Adhes 8:367-71. 2001
    Osteoblasts are highly coupled by gap junctions formed primarily by connexin43 (Cx43)...
  50. ncbi The organization of adherens junctions and desmosomes at the cardiac intercalated disc is independent of gap junctions
    David E Gutstein
    Division of Cardiology, Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    J Cell Sci 116:875-85. 2003
    ..We investigated whether the major cardiac gap junction protein connexin43 (Cx43) may be responsible for regulating adherens junctions, desmosomes and their associated catenins, in terms ..
  51. pmc Lens connexins alpha3Cx46 and alpha8Cx50 interact with zonula occludens protein-1 (ZO-1)
    Peter A Nielsen
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Mol Biol Cell 14:2470-81. 2003
    ..The spatial variation in the interaction of ZO-1 with lens gap junctions is intriguing and is suggestive of multiple dynamic roles for this association...
  52. ncbi Endothelin-1 decreases gap junctional intercellular communication by inducing phosphorylation of connexin 43 in human ovarian carcinoma cells
    Francesca Spinella
    Laboratories of Molecular Pathology and Ultrastructure and Immunology, Regina Elena Cancer Institute, Rome 00158, Italy
    J Biol Chem 278:41294-301. 2003
    ..carcinoma cell lines to ET-1 led to a 50-75% inhibition in intercellular communication and to a decrease in the connexin 43 (Cx43)-based gap junction plaques...
  53. ncbi Mice with astrocyte-directed inactivation of connexin43 exhibit increased exploratory behaviour, impaired motor capacities, and changes in brain acetylcholine levels
    Christian Frisch
    Institute of Physiological Psychology, and Center for Biological and Medical Research, Heinrich Heine University of Dusseldorf, Universitatsstrasse 1, D 40225 Dusseldorf, Germany
    Eur J Neurosci 18:2313-8. 2003
    ..b>Cx43 is the main constituent of the brain-spanning astrocytic gap junctional network, controlling activity-related ..
  54. ncbi The NLRR gene family and mouse development: Modified differential display PCR identifies NLRR-1 as a gene expressed in early somitic myoblasts
    Bryan P Haines
    Section of Gene Function and Regulation, The Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK
    Dev Biol 281:145-59. 2005
    ..The regulated embryonic expression and cellular location of these proteins suggest important roles during mouse development in the control of cell adhesion, movement or signalling...
  55. ncbi Distinct cardiac malformations caused by absence of connexin 43 in the neural crest and in the non-crest neural tube
    Shasha Liu
    Leon H Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Development 133:2063-73. 2006
    b>Connexin 43 (Cx43) is expressed in the embryonic heart, cardiac neural crest (CNC) and neural tube, and germline knockout (KO) of Cx43 results in aberrant cardiac outflow tract (OFT) formation and abnormal coronary deployment...
  56. ncbi Gap junctional control of glial glutamate transporter expression
    Maciej Figiel
    Institute of Anatomy, University of Leipzig, Medical Faculty, Liebigstr 13, 04103 Leipzig, Germany
    Mol Cell Neurosci 35:130-7. 2007
    ..Here, we show that uncoupling cultured cortical astrocytes with the gap junction blocker, propofol, or the Cx43 mimetic peptide, Gap27, inhibits the expression of GLT-1, the major glutamate transporter subtype in the cortex...
  57. ncbi Characterization of connexin31.1-deficient mice reveals impaired placental development
    Qingyi Zheng-Fischhöfer
    Institut fur Genetik, Abteilung Molekulargenetik, Universitat Bonn, D 53117 Bonn, Germany
    Dev Biol 312:258-71. 2007
    ..We conclude that Connexin31.1 is critical for normal placental development but appears to be functionally compensated by other connexin isoforms in the embryo proper and adult mouse...
  58. ncbi In vivo analysis of undocked connexin43 gap junction hemichannels in ovarian granulosa cells
    Dan Tong
    Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON N6A 5C1, Canada
    J Cell Sci 120:4016-24. 2007
    b>Connexin43 (Cx43, encoded by Gja1) is required for ovarian follicle development in the mouse. It is strongly expressed in granulosa cells, in which it forms intercellular gap junction channels that couple the cells metabolically...
  59. pmc The conditional connexin43G138R mouse mutant represents a new model of hereditary oculodentodigital dysplasia in humans
    Radoslaw Dobrowolski
    Institute of Genetics, University of Bonn, Germany
    Hum Mol Genet 17:539-54. 2008
    ..characteristic anomalies of the fingers and toes, eyes, face and teeth, which are caused by mutations in the connexin 43 (Cx43) gene...
  60. doi Tissue distribution and subcellular localization of the cardiac sodium channel during mouse heart development
    Jorge N Domínguez
    Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaen, Paraje de las Lagunillas, S N, Jaén 23071, Spain
    Cardiovasc Res 78:45-52. 2008
    ..The aim of this study was to analyse the mRNA expression levels and protein distribution of the cardiac sodium channel Scn5a/Nav1.5 during mouse cardiogenesis...
  61. doi A central role of connexin 43 in hypoxic preconditioning
    Jane H C Lin
    Department of Pathology, New York Medical College, Valhalla, New York 10595, USA
    J Neurosci 28:681-95. 2008
    ..Here we show that connexin 43 (Cx43) plays a key role in protection afforded by preconditioning...
  62. pmc Similar transcriptomic alterations in Cx43 knockdown and knockout astrocytes
    Dumitru A Iacobas
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cell Commun Adhes 15:195-206. 2008
    ..To start addressing this question, the authors compared with wild-type control the gene expression profiles of connexin 43 (Cx43) knockout and Cx43siRNA knockdown wild-type cortical astrocytes...
  63. pmc Lack of Connexin43-mediated bergmann glial gap junctional coupling does not affect cerebellar long-term depression, motor coordination, or eyeblink conditioning
    Mika Tanaka
    RIKEN Brain Science Institute BSI Japan
    Front Behav Neurosci 2:1. 2008
    ..b>Connexin43 (Cx43), a major component of astrocytic gap junction channels, is abundantly expressed in Bergmann glial cells...
  64. pmc Connexin43 potentiates osteoblast responsiveness to fibroblast growth factor 2 via a protein kinase C-delta/Runx2-dependent mechanism
    Florence Lima
    Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Mol Biol Cell 20:2697-708. 2009
    In this study, we examine the role of the gap junction protein, connexin43 (Cx43), in the transcriptional response of osteocalcin to fibroblast growth factor 2 (FGF2) in MC3T3 osteoblasts...
  65. ncbi Heart and neural tube defects in transgenic mice overexpressing the Cx43 gap junction gene
    J L Ewart
    Department of Biology, University of Pennsylvania, Philadelphia 19104, USA
    Development 124:1281-92. 1997
    ..containing a cytomegaloviral promoter driven construct (CMV43) expressing the gap junction polylpeptide connexin 43. RNA and protein analysis confirmed that the transgene was being expressed...
  66. pmc Transplacental uptake of glucose is decreased in embryonic lethal connexin26-deficient mice
    H D Gabriel
    Institut fur Genetik, Abt Molekulargenetik, Universitat Bonn, 53117 Bonn, Germany
    J Cell Biol 140:1453-61. 1998
    ....
  67. ncbi The loss of ventral ectoderm identity correlates with the inability to form an AER in the legless hindlimb bud
    S M Bell
    Division of Developmental Biology Children s Hospital Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Mech Dev 74:41-50. 1998
    ..These data suggest that establishment of a dorso-ventral ectodermal interface is not sufficient for AER formation and that restriction of lmx-1b to the dorsal mesenchyme is coordinately linked to AER formation...
  68. pmc Gap junction-mediated cell-cell communication modulates mouse neural crest migration
    G Y Huang
    Biology Department, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Cell Biol 143:1725-34. 1998
    ..Furthermore, they indicate that cardiac neural crest perturbation is the likely underlying cause for heart defects in mice with the gain or loss of alpha1 connexin function...
  69. ncbi Downregulation of connexin 45 gene products during mouse heart development
    S Alcolea
    Laboratoire de Genetique et Physiologie du Developpement, Institut de Biologie du Developpement de Marseille, CNRS INSERM AP Marseille Université de la Méditerranée, Campus de Luminy, Marseille
    Circ Res 84:1365-79. 1999
    ..Three members of this family have been demonstrated to be synthesized in the cardiomyocytes: Cx40, Cx43, and Cx45...
  70. ncbi Loss of connexin45 causes a cushion defect in early cardiogenesis
    M Kumai
    Department of Developmental Molecular Anatomy, Graduate School of Medical Science, Kyushu University, Fukuoka 812 8582, Japan
    Development 127:3501-12. 2000
    ..These results indicate a requirement for gap junction channels during early cardiogenesis and hence implicate connexin45 in congenital heart diseases. http://www. biologists.com/Development/movies/dev4369.html..
  71. ncbi Abnormal cardiac conduction and morphogenesis in connexin40 and connexin43 double-deficient mice
    S Kirchhoff
    Universitat Bonn, Institut fur Genetik, Abt Molekulargenetik, Bonn, Germany
    Circ Res 87:399-405. 2000
    Connexin40-deficient (Cx40(-/-)/Cx43(+/+)) and connexin43-heterozygous knockout mice (Cx40(+/+)/Cx43(+/-)) are viable but show cardiac conduction abnormalities...
  72. ncbi Transduction of cell survival signals by connexin-43 hemichannels
    Lilian I Plotkin
    Division of Endocrinology and Metabolism, the Center for Osteoporosis and Metabolic Bone Diseases, and the Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Biol Chem 277:8648-57. 2002
    ....
  73. ncbi Intercellular calcium signaling in astrocytes via ATP release through connexin hemichannels
    Charles E Stout
    Loma Linda University School of Medicine, Loma Linda, California 92350, USA
    J Biol Chem 277:10482-8. 2002
    ..Similar whole-cell currents, transmembrane dye flux, and ATP release were observed in C6 glioma cells expressing connexin43 but were not observed in parent C6 cells...
  74. ncbi A neuroprotective role for gap junctions
    C C Naus
    Department of Anatomy and Cell Biology, The University of Western Ontario, London, Canada
    Cell Commun Adhes 8:325-8. 2001
    ..In astrocytes, gap junctions are composed primarily of the channel protein, connexin43 (Cx43), and provide a substrate for formation of a functional syncytium implicated in the process of spatial ..
  75. ncbi Astrocytic gap junctions composed of connexin 43 reduce apoptotic neuronal damage in cerebral ischemia
    Taizen Nakase
    Department of Anatomy and Cell Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
    Stroke 34:1987-93. 2003
    ..b>Connexin 43 (Cx43) is one of the major gap junction proteins in astrocytes...
  76. ncbi Development of mice with osteoblast-specific connexin43 gene deletion
    Charles H M Castro
    Division of Bone and Mineral Diseases, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell Commun Adhes 10:445-50. 2003
    Genetic deficiency of Cx43 in vivo causes skeletal developmental defects, osteoblast dysfunction and perinatal lethality...
  77. ncbi Drebrin is a novel connexin-43 binding partner that links gap junctions to the submembrane cytoskeleton
    Eugenia Butkevich
    Department of Neurophysiology, University of Gottingen, Gottingen, Germany
    Curr Biol 14:650-8. 2004
    ..To identify novel proteins that interact with the COOH-terminal domain of Connexin-43 (Cx43), the most widely expressed connexin family member, we applied a proteomics approach to screen fractions of mouse ..
  78. ncbi mRNA expression pattern of multiple members of connexin gene family in normal and abnormal fetal gonads in mouse
    Subhash C Juneja
    Department of Zoology, The University of Western Ontario, London, Canada
    Indian J Physiol Pharmacol 47:147-56. 2003
    ..Gap junctions play important roles in ovarian and testicular function. Connexin 43 (Cx43) knockout mouse is a model for developmentally impaired fetal gonads...
  79. ncbi Connexin43 associated with an N-cadherin-containing multiprotein complex is required for gap junction formation in NIH3T3 cells
    Chih Jen Wei
    Laboratory of Developmental Biology, NHLBI, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    J Biol Chem 280:19925-36. 2005
    ..In NIH3T3 cells, we observed the colocalization of connexin43 (Cx43alpha1) gap junction protein with N-cadherin, p120, and other N-cadherin-associated proteins at regions of ..
  80. ncbi Connexin43 deficiency causes dysregulation of coronary vasculogenesis
    Diana L Walker
    Laboratory of Developmental Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Building 50 Room 4537, Bethesda, MD 20892 8019, USA
    Dev Biol 284:479-98. 2005
    The connexin43 knockout (Cx43alpha1 KO) mouse dies at birth from outflow obstruction associated with infundibular pouches...
  81. ncbi Connexin31 cannot functionally replace connexin43 during cardiac morphogenesis in mice
    Qingyi Zheng-Fischhöfer
    Institut fur Genetik, Universitat Bonn, 53117 Bonn, Germany
    J Cell Sci 119:693-701. 2006
    In the gastrulating mouse embryo, the gap junction protein connexin43 is expressed exclusively in cells derived from the inner cell mass, whereas connexin31 is expressed in cells of the trophoblast lineage...
  82. ncbi The impact of astrocytic gap junctional coupling on potassium buffering in the hippocampus
    Anke Wallraff
    Department of Experimental Neurobiology, Neurosurgery, University of Bonn, 53105 Bonn, Germany
    J Neurosci 26:5438-47. 2006
    ..We obtained mice with coupling-deficient astrocytes by crossing conditional connexin43-deficient mice with connexin30(-/-) mice...
  83. pmc Sphingosine 1-phosphate induces myoblast differentiation through Cx43 protein expression: a role for a gap junction-dependent and -independent function
    R Squecco
    Departments of Biochemical Sciences, University of Florence, Interuniversity Institute of Myology, Florence I 50134, Italy
    Mol Biol Cell 17:4896-910. 2006
    ..Indeed, the treatment with S1P greatly enhanced Cx43 expression and gap junctional intercellular communication during the early phases of myoblast differentiation, ..
  84. pmc Loss of mXinalpha, an intercalated disk protein, results in cardiac hypertrophy and cardiomyopathy with conduction defects
    Elisabeth A Gustafson-Wagner
    Department of Biological Sciences, University of Iowa, Iowa City, IA 52242, USA
    Am J Physiol Heart Circ Physiol 293:H2680-92. 2007
    ..Additionally, altered localization and decreased expression of connexin 43 are observed in the mXinalpha-null mouse heart, which, together with previously observed abnormal ..
  85. pmc Electrical remodeling contributes to complex tachyarrhythmias in connexin43-deficient mouse hearts
    Stephan B Danik
    Leon H Charney Division of Cardiology, New York University School of Medicine, New York, NY 10016, USA
    FASEB J 22:1204-12. 2008
    Loss of connexin43 (Cx43) gap junction channels in the heart results in a marked increase in the incidence of spontaneous and inducible polymorphic ventricular tachyarrhythmias (PVTs)...
  86. doi Combined reduction of intercellular coupling and membrane excitability differentially affects transverse and longitudinal cardiac conduction
    Mera Stein
    Division of Heart and Lungs, Department of Medical Physiology, University Medical Center Utrecht, Yalelaan 50, Utrecht, The Netherlands
    Cardiovasc Res 83:52-60. 2009
    ..In this study, we have investigated the effect of isolated and combined reductions in membrane excitability and intercellular coupling on impulse propagation and arrhythmogeneity in genetically modified mice...
  87. doi Loss of connexin43-mediated gap junctional coupling in the mesenchyme of limb buds leads to altered expression of morphogens in mice
    Radoslaw Dobrowolski
    Division of Molecular Genetics, Institute of Genetics, Berlin, Germany
    Hum Mol Genet 18:2899-911. 2009
    Mutations in the GJA1 gene coding for connexin43 (Cx43) cause oculodentodigital dysplasia (ODDD), a pleiotropic human disorder with characteristic morphologic anomalies of face, teeth, bones and digits...
  88. pmc Connexin 43 regulates epicardial cell polarity and migration in coronary vascular development
    David Y Rhee
    Laboratory of Developmental Biology, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Development 136:3185-93. 2009
    b>Connexin 43 knockout (Cx43 KO) mice exhibit conotruncal malformations and coronary artery defects...
  89. pmc Hypoxia in high glucose followed by reoxygenation in normal glucose reduces the viability of cortical astrocytes through increased permeability of connexin 43 hemichannels
    Juan A Orellana
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    Glia 58:329-43. 2010
    ..glucose during the hypoxia in a concentration-dependent manner (and by zero glucose) and were not observed in connexin 43(-/-) astrocytes...
  90. doi Decreased levels of Cx43 gap junctions result in ameloblast dysregulation and enamel hypoplasia in Gja1Jrt/+ mice
    K Toth
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada
    J Cell Physiol 223:601-9. 2010
    ..To assess the role of Cx43 in tooth development we employ a mouse model of ODDD that harbors a G60S Cx43 mutant, Gja1(Jrt)/+, and appears to exhibit tooth abnormalities that mimic the human disease...
  91. pmc Phosphatase-resistant gap junctions inhibit pathological remodeling and prevent arrhythmias
    Benjamin F Remo
    Leon H Charney Division of Cardiology, New York University School of Medicine, 522 First Ave, Smilow 801, New York, NY 10016, USA
    Circ Res 108:1459-66. 2011
    Posttranslational phosphorylation of connexin43 (Cx43) has been proposed as a key regulatory event in normal cardiac gap junction expression and pathological gap junction remodeling...
  92. doi Role of connexin43 and ATP in long-range bystander radiation damage and oncogenesis in vivo
    M Mancuso
    Laboratory of Radiation Biology and Biomedicine, Agenzia nazionale per le nuove tecnologie, l Energia e lo Sviluppo Economico Sostenibile ENEA CR Casaccia, Rome, Italy
    Oncogene 30:4601-8. 2011
    ..system using a mouse model in which intercellular communication is downregulated by targeted deletion of the connexin43 (Cx43) gene...
  93. pmc Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diurnal micturition rhythm
    Hiromitsu Negoro
    Department of Urology, Graduate School of Medicine, Kyoto University, Sakyo, Kyoto 606 8507, Japan
    Nat Commun 3:809. 2012
    ..Here we demonstrate, using a novel method for automated recording of mouse micturition, that connexin43, a bladder gap junction protein, is a negative regulator of functional bladder capacity...
  94. pmc Connexin 43 deficiency attenuates loss of trabecular bone and prevents suppression of cortical bone formation during unloading
    Shane A Lloyd
    Division of Musculoskeletal Sciences, Department of Orthopaedics and Rehabilitation, Penn State College of Medicine, Hershey, PA 17033, USA
    J Bone Miner Res 27:2359-72. 2012
    b>Connexin 43 (Cx43) is the most abundant gap junction protein in bone and has been demonstrated as an integral component of skeletal homeostasis...
  95. pmc Connexin43 and pannexin1 channels in osteoblasts: who is the "hemichannel"?
    Mia M Thi
    Department of Orthopedic Surgery, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Membr Biol 245:401-9. 2012
    ..Unapposed gap junction hemichannels formed of connexin43 (Cx43) have been proposed as a major route for such exchange, in particular for release of ATP and prostaglandin ..
  96. ncbi Identification of two regulatory elements within the promoter region of the mouse connexin 43 gene
    Z Q Chen
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    J Biol Chem 270:3863-8. 1995
    To define the minimal sequences required for expression of the connexin 43 gene (cx43) in myometrial cells, we generated 5' deletion constructs of a fragment extending 1686 base pairs upstream and 162 base pairs downstream of the ..
  97. ncbi Cardiac malformation in neonatal mice lacking connexin43
    A G Reaume
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Science 267:1831-4. 1995
    ..Targeted mutagenesis of connexin43 (Cx43), one of the most prevalent connexin proteins, showed that its absence was compatible with survival of ..
  98. ncbi Functional proteomic analysis of protein kinase C epsilon signaling complexes in the normal heart and during cardioprotection
    P Ping
    Department of Physiology, Division of Cardiology, University of Louisville, KY, USA
    Circ Res 88:59-62. 2001
    ..The results suggest heretofore-unrecognized functions of PKCepsilon and provide an integrated framework for the understanding of PKCepsilon-dependent signaling architecture and cardioprotection...
  99. ncbi Null mutation of connexin43 causes slow propagation of ventricular activation in the late stages of mouse embryonic development
    D Vaidya
    Department of Pharmacology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Circ Res 88:1196-202. 2001
    b>Connexin43 (Cx43) is the principal connexin isoform in the mouse ventricle, where it is thought to provide electrical coupling between cells...
  100. ncbi Connexin43 null mutation increases infarct size after stroke
    R Siushansian
    Department of Anatomy and Cell Biology, The University of Western Ontario, London, ON, Canada N6A 5C1
    J Comp Neurol 440:387-94. 2001
    ..In astrocytes, gap junctions are composed primarily of the channel protein connexin43 (Cx43) and provide a substrate for formation of a functional syncytium implicated in the spatial buffering ..
  101. ncbi An essential role for connexin43 gap junctions in mouse coronary artery development
    W E I Li
    Biology Department, Goddard Laboratories, University of Pennsylvania, Philadelphia, PA, USA
    Development 129:2031-42. 2002
    b>Connexin43 knockout mice die neonatally from conotruncal heart malformation and outflow obstruction. Previous studies have indicated the involvement of neural crest perturbations in these cardiac anomalies...

Research Grants14

  1. "Connexin-Dependent Transcriptomic Networks in Controlling the Heart Rhythm"
    DUMITRU ANDREI IACOBAS; Fiscal Year: 2010
    ..expression and/or mutation of the primary gap junction proteins (connexins, Cx) that couple myocytes in ventricles (Cx43) and atria (Cx40) among major causes of cardiac arrhythmias...
  2. Glial Signaling:Interplay of Connexins and P2 Receptors
    Eliana Scemes; Fiscal Year: 2006
    ..We have recently obtained evidence that astrocytes from Cx43 null mice display a different functional P2Y subtype expression compared to astrocytes from wildtype mice aTrd that ..
  3. Gap Junction Mediated Signaling and Vascular Responses
    Alexander M Simon; Fiscal Year: 2010
    ..Finally, these studies could also lead to new approaches to control vasculogenesis and angiogenesis in other clinically important settings, such as anti-angiogenesis treatments designed to fight cancer. ..
  4. SEARCH FOR NEW GENES CAUSING NON-SYNDROMIC DEAFNESS
    Xue Liu; Fiscal Year: 2002
    ..This knowledge is an essential prerequisite to the development and provision of molecular diagnostic services for families with NSHL, as well as the further delineation of the functional genomics of the cochlea. ..
  5. CONTROL OF CONNEXIN TRANSPORT AND ASSEMBLY
    Michael Koval; Fiscal Year: 2004
    ..We found that ROS cells differentially assemble and sort two endogenously expressed gap junction proteins, CX43 and CX46. ROS cells assemble CX43 into hexamers which are transported to the plasma membrane...
  6. EXERCISE HYPERTROPHY AND CONTROL OF MYOSIN INDUCTION
    Richard Tsika; Fiscal Year: 2008
    ..abstract_text> ..
  7. ALTERED MECHANICAL LOADS AND SKELETAL MUSCLE PHENOTYPE
    Richard Tsika; Fiscal Year: 2009
    ..abstract_text> ..
  8. Proteomic Biomarkers of Health Behaviors
    Paul Lampe; Fiscal Year: 2005
    ..abstract_text> ..
  9. Developmental Defects in Blood and Vessel Formation
    Karen Hirschi; Fiscal Year: 2007
    ..abstract_text> ..
  10. Resolving the nuclear fusion steps during yeast mating
    Patricia Melloy; Fiscal Year: 2006
    ..This information and the tools used can then be applied to other cell biological and gene regulation questions during other types of membrane fusion. ..
  11. Role of ALK3 in atrioventricular valve development
    Vinciane Gaussin; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  12. Molecular determinants of lung barrier function
    Michael Koval; Fiscal Year: 2009
    ....
  13. Tissue Engineering of Hematopoietic Bone
    Karen Hirschi; Fiscal Year: 2009
    ..Furthermore, we have established necessary links to BCM and Rice technology transfer offices to facilitate the transition of our research into biotech and clinical settings. ..
  14. RETINOID REGULATION OF BLOOD VESSEL FORMATION
    Karen Hirschi; Fiscal Year: 2004
    ..We will also specifically investigate the role(s) of retinoic acid and TGF-¿ signaling in the control of endothelial cell maturation and growth, as a direct extension of our previous work. ..