Gja4

Summary

Gene Symbol: Gja4
Description: gap junction protein, alpha 4
Alias: AU020209, AW558810, Cnx37, Cx37, Gja-4, gap junction alpha-4 protein, connexin-37, gap junction membrane channel protein alpha 4
Species: mouse

Top Publications

  1. pmc Dosage-sensitive requirement for mouse Dll4 in artery development
    Antonio Duarte
    CIISA, Faculdade de Medicina Veterinaria, 1300 0 477 Lisboa, Portugal
    Genes Dev 18:2474-8. 2004
  2. pmc Defective lymphatic valve development and chylothorax in mice with a lymphatic-specific deletion of Connexin43
    Stephanie J Munger
    Department of Physiology, University of Arizona, Tucson AZ 85724, USA Electronic address
    Dev Biol 421:204-218. 2017
  3. pmc Multiple mouse models of primary lymphedema exhibit distinct defects in lymphovenous valve development
    Xin Geng
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
    Dev Biol 409:218-33. 2016
  4. pmc The Increased Expression of Connexin and VEGF in Mouse Ovarian Tissue Vitrification by Follicle Stimulating Hormone
    Yanzhou Yang
    Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Key Laboratory of Reproduction and Genetics in Ningxia, Department of Histology and Embryology, Ningxia Medical University, Yinchuan 750004, China
    Biomed Res Int 2015:397264. 2015
  5. doi Shear stress-induced atherosclerotic plaque composition in ApoE(-/-) mice is modulated by connexin37
    A Pfenniger
    Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland Department of Medical Specializations Cardiology, University of Geneva, Geneva, Switzerland
    Atherosclerosis 243:1-10. 2015
  6. pmc Combining Foxc2 and Connexin37 deletions in mice leads to severe defects in lymphatic vascular growth and remodeling
    John D Kanady
    Department of Physiology, University of Arizona, Tucson, AZ 85724, USA Electronic address
    Dev Biol 405:33-46. 2015
  7. doi Cdk5 controls lymphatic vessel development and function by phosphorylation of Foxc2
    Johanna Liebl
    Department of Pharmacy, Pharmaceutical Biology, Ludwig Maximilians University, 81377 Munich, Germany
    Nat Commun 6:7274. 2015
  8. doi An important role of endothelial hairy-related transcription factors in mouse vascular development
    Takashi Morioka
    Laboratory for Cardiovascular System Research, Nara Medical University Advanced Medical Research Center, Kashihara, Nara, Japan The Second Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
    Genesis 52:897-906. 2014
  9. doi Prophase I arrest of mouse oocytes mediated by natriuretic peptide precursor C requires GJA1 (connexin-43) and GJA4 (connexin-37) gap junctions in the antral follicle and cumulus-oocyte complex
    Samantha Richard
    Ottawa Hospital Research Institute, Ottawa, Ontario, Canada, and Departments of Obstetrics and Gynecology, and Cellular and Molecular Medicine, University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada
    Biol Reprod 90:137. 2014
  10. doi Endothelial Cx40 limits myocardial ischaemia/reperfusion injury in mice
    Sandrine Morel
    Department of Pathology and Immunology, University of Geneva Medical School, CMU, Rue Michel Servet 1, CH 1211 Geneva 4, Switzerland
    Cardiovasc Res 102:329-37. 2014

Research Grants

  1. Gap Junction Mediated Signaling and Vascular Responses
    Alexander M Simon; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications86

  1. pmc Dosage-sensitive requirement for mouse Dll4 in artery development
    Antonio Duarte
    CIISA, Faculdade de Medicina Veterinaria, 1300 0 477 Lisboa, Portugal
    Genes Dev 18:2474-8. 2004
    ..This implicates Dll4 as the specific mammalian endothelial ligand for autocrine endothelial Notch signaling, and suggests that Dll4 may be a suitable target for intervention in arterial angiogenesis...
  2. pmc Defective lymphatic valve development and chylothorax in mice with a lymphatic-specific deletion of Connexin43
    Stephanie J Munger
    Department of Physiology, University of Arizona, Tucson AZ 85724, USA Electronic address
    Dev Biol 421:204-218. 2017
    ..These results demonstrate that the expression of Cx43 is specifically required in LECs for normal development of LVs...
  3. pmc Multiple mouse models of primary lymphedema exhibit distinct defects in lymphovenous valve development
    Xin Geng
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
    Dev Biol 409:218-33. 2016
    ..In summary, we have provided the first and the most comprehensive analysis of LVV development. Furthermore, our work suggests that aberrant LVVs contribute to lymphedema. ..
  4. pmc The Increased Expression of Connexin and VEGF in Mouse Ovarian Tissue Vitrification by Follicle Stimulating Hormone
    Yanzhou Yang
    Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Key Laboratory of Reproduction and Genetics in Ningxia, Department of Histology and Embryology, Ningxia Medical University, Yinchuan 750004, China
    Biomed Res Int 2015:397264. 2015
    ..The results suggested that the expressions of Cx37, Cx43, apoptotic molecular caspase-3, and angiogenesis molecular VEGF were confirmed using immunohistochemistry, ..
  5. doi Shear stress-induced atherosclerotic plaque composition in ApoE(-/-) mice is modulated by connexin37
    A Pfenniger
    Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland Department of Medical Specializations Cardiology, University of Geneva, Geneva, Switzerland
    Atherosclerosis 243:1-10. 2015
    ..Endothelial connexin37 (Cx37) expression is also regulated by shear stress, which may contribute to localization of atherosclerotic disease...
  6. pmc Combining Foxc2 and Connexin37 deletions in mice leads to severe defects in lymphatic vascular growth and remodeling
    John D Kanady
    Department of Physiology, University of Arizona, Tucson, AZ 85724, USA Electronic address
    Dev Biol 405:33-46. 2015
    ..Cell culture studies have shown that Cx37 is necessary for coordinated activation of the transcription factor NFATc1, which cooperates with Foxc2 (another ..
  7. doi Cdk5 controls lymphatic vessel development and function by phosphorylation of Foxc2
    Johanna Liebl
    Department of Pharmacy, Pharmaceutical Biology, Ludwig Maximilians University, 81377 Munich, Germany
    Nat Commun 6:7274. 2015
    ..Collectively, our findings show that Cdk5-Foxc2 interaction represents a critical regulator of lymphatic vessel development and the transcriptional network underlying lymphatic vascular remodeling. ..
  8. doi An important role of endothelial hairy-related transcription factors in mouse vascular development
    Takashi Morioka
    Laboratory for Cardiovascular System Research, Nara Medical University Advanced Medical Research Center, Kashihara, Nara, Japan The Second Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
    Genesis 52:897-906. 2014
    ....
  9. doi Prophase I arrest of mouse oocytes mediated by natriuretic peptide precursor C requires GJA1 (connexin-43) and GJA4 (connexin-37) gap junctions in the antral follicle and cumulus-oocyte complex
    Samantha Richard
    Ottawa Hospital Research Institute, Ottawa, Ontario, Canada, and Departments of Obstetrics and Gynecology, and Cellular and Molecular Medicine, University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada
    Biol Reprod 90:137. 2014
    ..b>Cx37 CMP, in contrast, had no effect when present in the medium, but released oocyte arrest in the presence of NPPC when ..
  10. doi Endothelial Cx40 limits myocardial ischaemia/reperfusion injury in mice
    Sandrine Morel
    Department of Pathology and Immunology, University of Geneva Medical School, CMU, Rue Michel Servet 1, CH 1211 Geneva 4, Switzerland
    Cardiovasc Res 102:329-37. 2014
    ..The role of the endothelial connexins, i.e. Cx40 and Cx37, in cardiac IR injury is, however, not known.
  11. pmc High bone mass in mice lacking Cx37 because of defective osteoclast differentiation
    Rafael Pacheco-Costa
    From the Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202
    J Biol Chem 289:8508-20. 2014
    ..We now report that Cx37, another member of the connexin family of proteins, is expressed in osteoclasts, osteoblasts, and osteocytes...
  12. pmc Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development
    Yujung Kang
    Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06511, USA
    Circ Res 113:22-31. 2013
    ..The peptide ligand apelin and its receptor APJ constitute a signaling pathway with numerous effects on the cardiovascular system, including cardiovascular development in model organisms such as xenopus and zebrafish...
  13. pmc Gap junctions and connexin hemichannels underpin hemostasis and thrombosis
    Sakthivel Vaiyapuri
    Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading, Hopkins Bldg, Reading, RG6 6UB, UK
    Circulation 125:2479-91. 2012
    ..We have examined the role of connexins in platelets, blood cells that circulate in isolation but on tissue injury adhere to each other and the vessel wall to prevent blood loss and to facilitate wound repair...
  14. pmc Cx40 is required for, and cx37 limits, postischemic hindlimb perfusion, survival and recovery
    Jennifer S Fang
    Department of Physiology, University of Arizona Health Sciences Center, Tucson, Ariz, USA
    J Vasc Res 49:2-12. 2012
    ..Vascular endothelium predominantly expresses two connexin (Cx) isoforms: Cx37 and Cx40. The relevance of these Cxs to postischemic limb recovery remains unclear.
  15. doi Mechanotransduction, PROX1, and FOXC2 cooperate to control connexin37 and calcineurin during lymphatic-valve formation
    Amélie Sabine
    Division of Experimental Oncology, Multidisciplinary Oncology Center, University Hospital of Lausanne, Switzerland
    Dev Cell 22:430-45. 2012
    ..Our results also provide molecular insights into the role of endothelial cell identity in the regulation of vascular mechanotransduction...
  16. doi Shear stress modulates the expression of the atheroprotective protein Cx37 in endothelial cells
    Anna Pfenniger
    Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland
    J Mol Cell Cardiol 53:299-309. 2012
    ..Connexin37 (Cx37) is highly expressed in endothelial cells (ECs) of healthy arteries, but not in ECs overlying atherosclerotic ..
  17. pmc Absence of venous valves in mice lacking Connexin37
    Stephanie J Munger
    Department of Physiology, University of Arizona, Tucson, AZ 85724, USA
    Dev Biol 373:338-48. 2013
    ..Here, we show that in valved veins of the mouse, three gap junction proteins (Connexins, Cxs), Cx37, Cx43, and Cx47, are expressed exclusively in the valves in a highly polarized fashion, with Cx43 on the upstream ..
  18. ncbi Chromosomal assignments of mouse connexin genes, coding for gap junctional proteins, by somatic cell hybridization
    H J Schwarz
    Institut fur Genetik, Abt Molekulargenetik, Universitat Bonn, Germany
    Somat Cell Mol Genet 18:351-9. 1992
    ..In addition, our results confirm the recent assignment of mouse connexin genes Cx26, Cx32, Cx37, Cx40, Cx43, and Cx46 to mouse chromosomes 14, X, 4, 3, 10, and 14, respectively, by analysis of interspecific ..
  19. ncbi Cx31 and Cx43 double-deficient mice reveal independent functions in murine placental and skin development
    Mark Kibschull
    Institute of Anatomy, University Hospital Duisburg Essen, Essen, Germany
    Dev Dyn 233:853-63. 2005
    ..Therefore, in epidermal and preimplantation development, gap junctional communication can probably be compensated by other isoforms coexpressed with Cx31 and Cx43...
  20. ncbi Isolation of arterial-specific genes by subtractive hybridization reveals molecular heterogeneity among arterial endothelial cells
    Donghun Shin
    Division of Biology 216 76, California Institute of Technology, Pasadena, California 91125, USA
    Dev Dyn 233:1589-604. 2005
    ..Taken together, these data reveal unanticipated temporal and spatial heterogeneity among arterial endothelial cells of various tissues and organs, raising new questions regarding the functional significance of this diversity...
  21. ncbi Differential connexin expression in preglomerular and postglomerular vasculature: accentuation during diabetes
    Jianhong Zhang
    Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    Kidney Int 68:1171-85. 2005
    ..We have therefore made a comprehensive analysis of connexin expression in the renal vasculature of control and diabetic mice since elevated glucose has been reported to down-regulate connexin 43 in vascular cells in vitro...
  22. pmc The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis
    Koichi Hamada
    Department of Molecular Biology, Department of Microbiology, Department of Gastroenterology, Akita University School of Medicine, Akita 010 8543, Japan
    Genes Dev 19:2054-65. 2005
    ..Pten is thus indispensable for normal cardiovascular morphogenesis and post-natal angiogenesis, including tumor angiogenesis...
  23. ncbi Reduced arteriolar conducted vasoconstriction in septic mouse cremaster muscle is mediated by nNOS-derived NO
    Rebecca L McKinnon
    Lawson Health Research Institute, The Centre for Critical Illness Research, Victoria Research Laboratory, 6th Floor, 800 Commissioners Road East London, Ontario, Canada, N6C 2V5
    Cardiovasc Res 69:236-44. 2006
    ..vasoconstriction, (ii) to identify which nitric oxide synthase (NOS) isoforms account for this deficit, and (iii) to examine the potential role of connexin37 (Cx37, a hypothesized signaling target of NO) in arteriolar conduction.
  24. ncbi Differential contributions of connexin37 and connexin43 to oogenesis revealed in chimeric reaggregated mouse ovaries
    Joanne E I Gittens
    Department of Physiology and Pharmacology, The University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Cell Sci 118:5071-8. 2005
    ....
  25. ncbi Preferential expression of connexin37 and connexin40 in the endothelium of the portal veins during mouse liver development
    Nobuyoshi Shiojiri
    Department of Biology, Faculty of Science, Shizuoka University, Oya 836, Shizuoka City, Shizuoka 422 8529, Japan
    Cell Tissue Res 324:547-52. 2006
    ..The differentiation of each blood vessel in the hepatic vascular system may occur in early developmental stages, soon after hepatic primordium formation...
  26. ncbi Connexin37 protects against atherosclerosis by regulating monocyte adhesion
    Cindy W Wong
    Division of Cardiology, Department of Internal Medicine, Geneva University Hospitals, CH 1211 Geneva, Switzerland
    Nat Med 12:950-4. 2006
    A genetic polymorphism in the human gene encoding connexin37 (CX37, encoded by GJA4, also known as CX37) has been reported as a potential prognostic marker for atherosclerosis...
  27. ncbi ERRgamma directs and maintains the transition to oxidative metabolism in the postnatal heart
    William A Alaynick
    Howard Hughes Medical Institute and Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cell Metab 6:13-24. 2007
    ..These findings reveal an unexpected and essential molecular genetic component of the oxidative metabolic gene program in the heart and highlight ERRgamma in the study of cardiac hypertrophy and failure...
  28. ncbi Expression of connexins in embryonic mouse neocortical development
    Cima Cina
    Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
    J Comp Neurol 504:298-313. 2007
    ..blot analysis, and immunohistochemistry, we found that among the family of gap junction proteins, Cx26, Cx36, Cx37, Cx43, and Cx45 were expressed in the developing cortex of mice, Cx30 and Cx32 were absent, while Cx40 was ..
  29. pmc Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos
    Alexandre Trindade
    Centro de Informatica do Instituto Superior de Agronomia CIISA, Lisbon Technical University, Lisbon, Portugal
    Blood 112:1720-9. 2008
    ..These results establish the role of Dll4 in arterial identity determination, and regulation of angiogenesis subject to dose and location...
  30. pmc Connexin 37 profoundly slows cell cycle progression in rat insulinoma cells
    Janis M Burt
    Dept of Physiology, P O Box 245051, Univ of Arizona, Tucson, AZ 85724, USA
    Am J Physiol Cell Physiol 295:C1103-12. 2008
    ..To assess its potential growth-suppressive function, we stably introduced connexin 37 (Cx37) into connexin-deficient, tumorigenic rat insulinoma (Rin) cells under the control of an inducible ..
  31. pmc Dissection of two Cx37-independent conducted vasodilator mechanisms by deletion of Cx40: electrotonic versus regenerative conduction
    Xavier F Figueroa
    Departamento de Ciencias Fisiologicas, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Am J Physiol Heart Circ Physiol 295:H2001-7. 2008
    ..Connexin40 is essential for the ACh-activated regenerative vasodilator mechanism. However, neither connexin40 nor connexin37 is indispensable for the electrotonic spread of hyperpolarizing signals...
  32. pmc Connexin expression in renin-producing cells
    Lisa Kurtz
    Institute of Physiology, University of Regensburg, Regensburg, Germany
    J Am Soc Nephrol 20:506-12. 2009
    ..In the adult kidney, juxtaglomerular epithelioid cells expressed Cx40 and lesser amounts of Cx37 and Cx43 but not Cx45, which localized to arteriolar smooth muscle cells...
  33. pmc Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli
    Rui Benedito
    Centro Interdisciplinar de Investigação em Sanidade Animal, Faculdade de Medicina Veterinaria, Technical University of Lisbon, Lisboa, Portugal
    BMC Dev Biol 8:117. 2008
    ..Dll4 null embryos die very early in development with severely reduced arterial calibre and lumen and loss of arterial cell identity...
  34. doi Connexin37 mRNA expression in in vivo and in vitro mouse oocyte
    Bao Ying Yin
    College of Veterinary Medicine, Northwest A and F University, Yangling, Shaanxi Province, People s Republic of China
    Zygote 17:163-8. 2009
    To evaluate gene expression of Connexin37 (Cx37) in oocytes from in vitro follicles at different stages, mouse preantral follicles were isolated and cultured for 12 days in vitro...
  35. doi Molecular role of Cx37 in advanced atherosclerosis: a micro-array study
    Jean Paul Derouette
    Division of Cardiology, Department of Internal Medicine, Geneva University Hospitals and University of Geneva, 64 Avenue de la Roseraie, Geneva, Switzerland
    Atherosclerosis 206:69-76. 2009
    Recently, we showed that connexin37 (Cx37) protects against early atherosclerotic lesion development by regulating monocyte adhesion...
  36. pmc Reduction of electrical coupling between microvascular endothelial cells by NO depends on connexin37
    Rebecca L McKinnon
    Critical Illness Research, Lawson Health Research Institute, London, Ontario, Canada
    Am J Physiol Heart Circ Physiol 297:H93-H101. 2009
    ..In the present study, we hypothesized that NO impairs interendothelial electrical coupling in sepsis by targeting Cx37. We examined the effect of exogenous NO on coupling in monolayers of cultured microvascular endothelial cells ..
  37. doi Connexin 37 is localized in renal epithelia and responds to changes in dietary salt intake
    Adelina Stoessel
    Institute of Anatomy, Charite Universitatsmedizin Berlin, Berlin, Germany
    Am J Physiol Renal Physiol 298:F216-23. 2010
    ..Renal vascular expression and hemodynamic impacts have so far been shown for Cx37, Cx40, and Cx43. Additionally, Cx30, Cx30...
  38. pmc Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling
    Ming Hu
    State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Proc Natl Acad Sci U S A 107:2956-61. 2010
    ..Taken together, these results indicate that Hypb is required for embryonic vascular remodeling and provide a tool to study the function of H3K36 methylation in vasculogenesis/angiogenesis...
  39. pmc Connexin37 and Connexin43 deficiencies in mice disrupt lymphatic valve development and result in lymphatic disorders including lymphedema and chylothorax
    John D Kanady
    Department of Physiology, University of Arizona, Tucson, AZ 85724, USA
    Dev Biol 354:253-66. 2011
    ..Here, we report that gap junction proteins, or connexins (Cxs), are required for lymphatic valvulogenesis. Cx37 and Cx43 are expressed early in mouse lymphatic development in the jugular lymph sacs, and later in development ..
  40. pmc Stepwise arteriovenous fate acquisition during mammalian vasculogenesis
    Diana C Chong
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Dev Dyn 240:2153-65. 2011
    ..Together, our results provide a first spatiotemporal analysis of mammalian AV cell fate establishment and anatomy, as well as a delineation of a molecular toolkit for analysis of arteries and veins during early vessel development...
  41. doi Connexin 37 limits thrombus propensity by downregulating platelet reactivity
    Anne Angelillo-Scherrer
    Service and Central Laboratory of Hematology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Rue du Bugnon 46, CH 1011 Lausanne, Switzerland
    Circulation 124:930-9. 2011
    ..Connexins comprise a family of proteins that form gap junctions enabling intercellular coordination of tissue activity, a process termed gap junctional intercellular communication...
  42. pmc Cx37 deletion enhances vascular growth and facilitates ischemic limb recovery
    Jennifer S Fang
    Department of Physiology, University of Arizona, Tucson, Arizona, USA
    Am J Physiol Heart Circ Physiol 301:H1872-81. 2011
    ..We recently reported that Cx37-deficient (Cx37(-/-)) animals recovered ischemic hindlimb function more quickly and to a greater extent than wild-..
  43. ncbi Expression pattern of connexin gene products at the early developmental stages of the mouse cardiovascular system
    B Delorme
    Laboratoire de Genetique et Physiologie du Developpement, UMR C9943, Institut de Biologie du Developpement de Marseille, France
    Circ Res 81:423-37. 1997
    ..Products of several Cx genes have been identified in the mammalian heart (eg, Cx45, Cx43, Cx40, and Cx37), and their expression was shown to be regulated during the development of the myocardium...
  44. ncbi Loss of connexin45 causes a cushion defect in early cardiogenesis
    M Kumai
    Department of Developmental Molecular Anatomy, Graduate School of Medical Science, Kyushu University, Fukuoka 812 8582, Japan
    Development 127:3501-12. 2000
    ..These results indicate a requirement for gap junction channels during early cardiogenesis and hence implicate connexin45 in congenital heart diseases. http://www. biologists.com/Development/movies/dev4369.html..
  45. ncbi Connexin37 in normal and pathological development of mouse heart and great arteries
    J A Haefliger
    Department of Internal Medicine, University Hospital, Lausanne, Switzerland
    Dev Dyn 218:331-44. 2000
    b>Cx37 is a member of the connexin family of gap junction proteins, whose distribution in heart remains controversial...
  46. ncbi Connexin expression in the retina
    G Sohl
    Institut fur Genetik, Abteilung fur Molekulargenetik, Universitat Bonn, Germany
    Brain Res Brain Res Rev 32:138-45. 2000
    ..b>Cx37 was expressed in retinal endothelial cells...
  47. ncbi Role of connexin (gap junction) genes in cell growth control and carcinogenesis
    H Yamasaki
    Unit of Multistage Carcinogenesis, International Agency for Research on Cancer, Lyon, France
    C R Acad Sci III 322:151-9. 1999
    ..Thus, connexin genes can exert dual effects in tumour control: tumour suppression and a bystander effect for cancer therapy...
  48. ncbi Genetic diseases and gene knockouts reveal diverse connexin functions
    T W White
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Physiol 61:283-310. 1999
    ..In addition, gene targeting of connexins in mice has provided new insights into connexin function and the significance of connexin diversity...
  49. ncbi Genes, gene knockouts, and mutations in the analysis of gap junctions
    C W Lo
    Department of Biology, University of Pennsylvania, Philadelphia 19104 6017, USA
    Dev Genet 24:1-4. 1999
    ..It may be timely to form a Nomenclature Committee to establish a uniform classification scheme for naming gap junction proteins...
  50. ncbi Diverse functions of vertebrate gap junctions
    A M Simon
    Dept of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Trends Cell Biol 8:477-83. 1998
    ....
  51. pmc Transplacental uptake of glucose is decreased in embryonic lethal connexin26-deficient mice
    H D Gabriel
    Institut fur Genetik, Abt Molekulargenetik, Universitat Bonn, 53117 Bonn, Germany
    J Cell Biol 140:1453-61. 1998
    ....
  52. ncbi Heart defects in connexin43-deficient mice
    J Ya
    Department of Anatomy and Embryology, Academic Medical Center, University of Amsterdam, The Netherlands
    Circ Res 82:360-6. 1998
    ....
  53. ncbi The uroguanylin gene (Guca1b) is linked to guanylin (Guca2) on mouse chromosome 4
    T L Whitaker
    Division of Pediatric Gastroenterology and Nutrition, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    Genomics 45:348-54. 1997
    ..It is likely that uroguanylin and guanylin represent gene duplications that have evolved to allow overlapping and complementary patterns of expression in the intestine...
  54. ncbi Differential expression and localisation of connexin-37 and connexin-43 in follicles of different stages in the 4-week-old mouse ovary
    Stefan Cuoni Teilmann
    Laboratory of Reproductive Biology, Juliane Marie Centre, Rigshospitalet Section 5712, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Mol Cell Endocrinol 234:27-35. 2005
    ..membrane-bound, aqueous channels that couple adjacent cells ionically and gap junction proteins, connexin-37 (Cx37) and connexin-43 (Cx43) both participate in sustaining proper growth and maturation of the oocyte...
  55. ncbi The Bmp8 gene is expressed in developing skeletal tissue and maps near the Achondroplasia locus on mouse chromosome 4
    R J DiLeone
    Department of Developmental Biology, Stanford University School of Medicine, Palo Alto, California 94304 5427, USA
    Genomics 40:196-8. 1997
  56. ncbi Cloning and characterization of two vertebrate homologs of the Drosophila eyes absent gene
    J E Zimmerman
    Department of Biology, University of Pennsylvania, Philadelphia, USA
    Genome Res 7:128-41. 1997
    ..Our findings support the notion that several families of genes (Pax-6/eyeless, Six-3/sine oculis, and Eya) play related and critical roles in the eye for both files and vertebrates...
  57. ncbi Female infertility in mice lacking connexin 37
    A M Simon
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 385:525-9. 1997
    ..Here we show that connexin 37 is present in gap junctions between oocyte and granulosa cells and that connexin 37-deficient mice lack mature (..
  58. ncbi Expression of the gap junction proteins connexin31 and connexin43 correlates with communication compartments in extraembryonic tissues and in the gastrulating mouse embryo, respectively
    E Dahl
    Abt Molekulargenetik, Universitat Bonn, Germany
    J Cell Sci 109:191-7. 1996
    ..The communication boundary between those compartments may be due to incompatibility of connexin31 and connexin43 hemichannels, which do not communicate with each other in cell culture...
  59. ncbi Multiple members of the connexin gene family participate in preimplantation development of the mouse
    T C Davies
    Department of Zoology, University of Western Ontario, London, Canada
    Dev Genet 18:234-43. 1996
    ..The expression of multiple connexin genes during this early period of embryogenesis (when there are only two distinct cell types) raises questions about the functional significance of connexin diversity in this context...
  60. ncbi Developmental regulation of connexin 40 gene expression in mouse heart correlates with the differentiation of the conduction system
    B Delorme
    Laboratoire de Genetique et Physiologie du Developpement, Institut de Biologie du Developpement de Marseille, Faculte des Sciences de Luminy, Universite de la Mediterranee, France
    Dev Dyn 204:358-71. 1995
    ..e., CX37, CX43, and CX45, with a decreasing abundance as development proceeds...
  61. ncbi CTL induction by a tumour-associated antigen octapeptide derived from a murine lung carcinoma
    O Mandelboim
    Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Nature 369:67-71. 1994
    ..to isolate and sequence Lewis lung carcinoma (3LL)-specific peptide(s), which shows sequence homology to the connexin 37 protein...
  62. ncbi Six genes of the human connexin gene family coding for gap junctional proteins are assigned to four different human chromosomes
    K Willecke
    Institut für Genetik Abt Molekulargenetik Universität, Bonn Bundesrepublik Deutschland
    Eur J Cell Biol 53:275-80. 1990
    ..From our results subchromosomal assignments can be deduced for the human cx32 gene to Xq13-p11, the human cx37 gene as well as the human cx40 gene to 1pter-q12, and the human cx43 gene to 6q14-qter...
  63. pmc Mouse connexin37: cloning and functional expression of a gap junction gene highly expressed in lung
    K Willecke
    Abt Molekulargenetik, Universitat Bonn, Germany
    J Cell Biol 114:1049-57. 1991
    The coding sequence (333 amino acids) of a new connexin protein, designated mouse connexin37 (Cx37 or Cx37.6) due to the deduced theoretical molecular mass of 37.600 kD, has been determined from cDNA and genomic clones...
  64. ncbi Oocyte-granulosa cell heterologous gap junctions are required for the coordination of nuclear and cytoplasmic meiotic competence
    M J Carabatsos
    Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts 02111, USA
    Dev Biol 226:167-79. 2000
    ..in juvenile mice deficient in heterologous oocyte-granulosa cell gap junctions due to targeted deletion of Gja4, the gene encoding connexin-37...
  65. ncbi Dysregulation of connexins and inactivation of NFATc1 in the cardiovascular system of Nkx2-5 null mutants
    Laurent Dupays
    Laboratoire de Génétique et Physiologie du Développement UMR CNRS 6545, Institut de Biologie du Developpement de Marseille, Universite de la Mediterranee, 13288 Marseille Cedex 9, France
    J Mol Cell Cardiol 38:787-98. 2005
    ..In the mutant embryos the aorta is collapsed, and the vascular endothelial Cxs, Cx40 and Cx37, are no longer expressed in its posterior region...
  66. ncbi The novel mouse connexin39 gene is expressed in developing striated muscle fibers
    Julia von Maltzahn
    Institut fur Genetik, Abteilung Molekulargenetik, Universitat Bonn, Römerstr 164, 53117 Bonn, Germany
    J Cell Sci 117:5381-92. 2004
    ..As expression of no other known connexin could be verified in these cells, intercellular dye transfer might result from functional expression of Cx39 in developing striated muscle fibers...
  67. ncbi mRNA expression pattern of multiple members of connexin gene family in normal and abnormal fetal gonads in mouse
    Subhash C Juneja
    Department of Zoology, The University of Western Ontario, London, Canada
    Indian J Physiol Pharmacol 47:147-56. 2003
    ..5 dpc knockout (Cx43-/-) fetuses. The mRNA expression pattern of connexins (Cx26, Cx30.3, Cx31, Cx31.1, Cx32, Cx37, Cx40, Cx43, Cx45, Cx46 and Cx50) was analyzed by RT-PCR...
  68. ncbi Genotypes associated with myocardial infarction risk are more common in African Americans than in European Americans
    David E Lanfear
    Washington University School of Medicine, Department of Medicine, St Louis, Missouri 63110 1093, USA
    J Am Coll Cardiol 44:165-7. 2004
    ..This study was designed to describe the frequencies of multiple myocardial infarction (MI) risk-associated genotypes among different racial groups...
  69. ncbi Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice
    Tatsuo Furuyama
    Department of Molecular Genetics and Geriatric Research, National Institute for Longevity Sciences, Kumamoto University, Kumamoto 860 0811, Japan
    J Biol Chem 279:34741-9. 2004
    ..These results suggest that Foxo1 is essential to the ability of endothelial cells to respond properly to a high dose of VEGF, thereby playing a critical role in normal vascular development...
  70. ncbi Selective assembly of connexin37 into heterocellular gap junctions at the oocyte/granulosa cell interface
    Gregory I Veitch
    Department of Physiology and Pharmacology, The University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Cell Sci 117:2699-707. 2004
    ..of mice with targeted disruptions of specific connexin genes have revealed that at least two connexins, connexin37 (Cx37) and connexin43 (Cx43), play essential roles in ovarian follicle development...
  71. ncbi An expression atlas of connexin genes in the mouse
    Annalisa Buniello
    Telethon Institute of Genetics and Medicine, Via P Castellino 111, 80131 Naples, Italy
    Genomics 83:812-20. 2004
    ....
  72. ncbi Heart and head defects in mice lacking pairs of connexins
    Alexander M Simon
    Department of Physiology, University of Arizona, Tucson, AZ 85724, USA
    Dev Biol 265:369-83. 2004
    ..Of the 20 connexins in vertebrates, four are expressed in developing heart: connexin37 (Cx37), connexin40 (Cx40), connexin43 (Cx43), and connexin45 (Cx45)...
  73. ncbi Role of connexin37 and connexin40 in vascular development
    Alexander M Simon
    Department of Physiology, University of Arizona, Tucson, Arizona, USA
    Cell Commun Adhes 10:379-85. 2003
    Mice lacking both connexin37 (Cx37) and connexin40 (Cx40), gap junction proteins expressed in vascular endothelium, die perinatally with pronounced vascular abnormalities. Early vasculogenesis proceeds normally, but by E18...
  74. ncbi An update on connexin genes and their nomenclature in mouse and man
    Goran Sohl
    Institut fur Genetik, Universitat Bonn, Germany
    Cell Commun Adhes 10:173-80. 2003
    ..Furthermore, this short review contains an update on phenotypic correlations between connexin deficient mice and patients bearing mutations in their orthologous connexin genes...
  75. ncbi Retinoic acid regulates endothelial cell proliferation during vasculogenesis
    Lihua Lai
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Development 130:6465-74. 2003
    ..Thus, these data indicate that RA plays a crucial role in mammalian vascular development; it is required to control endothelial cell proliferation and vascular remodeling during vasculogenesis...
  76. ncbi Vascular abnormalities in mice lacking the endothelial gap junction proteins connexin37 and connexin40
    Alexander M Simon
    Department of Physiology, University of Arizona, Tucson, 85724, USA
    Dev Biol 251:206-20. 2002
    ..Mice lacking either connexin37 (Cx37) or connexin40 (Cx40), the predominant gap junction proteins present in vascular endothelium, are viable and ..
  77. ncbi Two interactive genes responsible for a new inherited cataract (RCT) in the mouse
    Y Y Maeda
    The Tokyo Metropolitan Institute of Medical Science Rinshoken, Dept of Laboratory Animal Science, Japan
    Mamm Genome 12:278-83. 2001
    ..The rct locus essential for the onset of the cataract was tightly linked to D4Mit278 on Chromosome (Chr) 4 with no recombination. The mrct locus was closely linked to D5Mit239 (chi2 = 66.3, P << 0.00001) on Chr 5...
  78. ncbi Mouse connexin37: gene structure and promoter analysis
    K H Seul
    Department of Physiology and Institute for Cardiovascular Research, Chonbuk National Univeristy, Chonbuk Medical School, Chonju, South Korea
    Biochim Biophys Acta 1492:499-504. 2000
    Connexin37 (Cx37) is a subunit gap junction protein which exhibits limited expression in only a few cell types, predominantly in endothelial cells and in the lung. To begin to analyze Cx37 expression, we isolated a 1...
  79. ncbi Rescue of oogenesis in Cx37-null mutant mice by oocyte-specific replacement with Cx43
    Tony Y Li
    Department of Physiology and Pharmacology, Obstetrics and Gynaecology, Paediatrics, The University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Cell Sci 120:4117-25. 2007
    ..In growing follicles of the mouse, gap junctions between oocytes and granulosa cells are assembled from connexin 37 (Cx37, encoded by Gja4), whereas those between granulosa cells are assembled from connexin 43 (Cx43, encoded by ..
  80. pmc Decreased oocyte-granulosa cell gap junction communication and connexin expression in a type 1 diabetic mouse model
    Ann M Ratchford
    Department of Obstetrics and Gynecology, Washington University in St Louis, St Louis, Missouri 63110, USA
    Mol Endocrinol 22:2643-54. 2008
    ..Real-time RT-PCR analyses confirmed the presence of Cx26, Cx37, and Cx57 mRNA and revealed a significant decrease in Cx37 mRNA expression in oocytes from diabetic mice compared ..
  81. ncbi The gene for human gap junction protein connexin37 (GJA4) maps to chromosome 1p35.1, in the vicinity of D1S195
    G Van Camp
    Department of Medical Genetics, University of Antwerp, Belgium
    Genomics 30:402-3. 1995
  82. ncbi Altered dye diffusion and upregulation of connexin37 in mouse aortic endothelium deficient in connexin40
    Olaf Krüger
    Institut fur Genetik, Abteilung Molekulargenetik, Universitat Bonn, Deutschland
    J Vasc Res 39:160-72. 2002
    Connexin40 (Cx40), connexin37 (Cx37) and connexin43 (Cx43) are subunit proteins of gap junction channels in the vascular wall which are presumably involved in the propagation of vasomotor signals...
  83. ncbi Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping
    J A Haefliger
    Department of Anatomy and Cellular Biology, Harvard Medical School, Boston, Massachusetts 02115
    J Biol Chem 267:2057-64. 1992
    ..On the basis of their predicted molecular mass, these proteins have been designated connexin (Cx) 40 (Cx40), Cx37, Cx33, and Cx31.1...
  84. ncbi Decreased intercellular dye-transfer and downregulation of non-ablated connexins in aortic endothelium deficient in connexin37 or connexin40
    Alexander M Simon
    Department of Physiology, University of Arizona, Tucson, AZ 85724, USA
    J Cell Sci 116:2223-36. 2003
    ..Connexin37 (Cx37) and connexin40 (Cx40) are the predominant gap-junction proteins present in mouse endothelium...
  85. ncbi Knockout mouse model and gametogenic failure
    J A Grootegoed
    Department of Endocrinology and Reproduction, Faculty of Medicine and Health Sciences, Erasmus University Rotterdam, The Netherlands
    Mol Cell Endocrinol 145:161-6. 1998
    ..The focus will be on the mHR6B gene knockout mouse, which shows male infertility. The mHR6B gene encodes an ubiquitin-conjugating enzyme, and the data point to an important role of the ubiquitin pathway in gametogenesis...
  86. ncbi Patch-clamp study reveals that the importance of connexin43-mediated gap junctional communication for ovarian folliculogenesis is strain specific in the mouse
    Dan Tong
    Dept of Physiology and Pharmacology, The Univ of Western Ontario, Dental Science Bldg, Rm 00073, London, ON, Canada N6A 5C1
    Am J Physiol Cell Physiol 290:C290-7. 2006
    Genetic ablation of connexin37 (Cx37) or connexin43 (Cx43), the two gap junction proteins expressed by mouse ovarian granulosa cells, has been shown to result in impaired follicle development...

Research Grants1

  1. Gap Junction Mediated Signaling and Vascular Responses
    Alexander M Simon; Fiscal Year: 2010
    ..In the first specific aim, the role of Cx37 and Cx40 in vascular development and angiogenesis is investigated...