Genomes and Genes
Gene Symbol: Gja5
Description: gap junction protein, alpha 5
Alias: 5730555N10Rik, Cnx40, Cx40, Gja-5, gap junction alpha-5 protein, connexin-40, gap junction membrane channel protein alpha 5
Publications142 found, 100 shown here
- Expression pattern of connexin gene products at the early developmental stages of the mouse cardiovascular systemB Delorme
Laboratoire de Genetique et Physiologie du Developpement, UMR C9943, Institut de Biologie du Developpement de Marseille, France
Circ Res 81:423-37. 1997..Products of several Cx genes have been identified in the mammalian heart (eg, Cx45, Cx43, Cx40, and Cx37), and their expression was shown to be regulated during the development of the myocardium...
- Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch blockA M Simon
Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
Curr Biol 8:295-8. 1998..the expression of connexins - the family of proteins from which gap junctions are formed - reveal that connexin40 (Cx40) is prominent in the conduction system ...
- Loss of connexin45 causes a cushion defect in early cardiogenesisM Kumai
Department of Developmental Molecular Anatomy, Graduate School of Medical Science, Kyushu University, Fukuoka 812 8582, Japan
Development 127:3501-12. 2000..These results indicate a requirement for gap junction channels during early cardiogenesis and hence implicate connexin45 in congenital heart diseases. http://www. biologists.com/Development/movies/dev4369.html..
- Patterning the embryonic heart: identification of five mouse Iroquois homeobox genes in the developing heartV M Christoffels
Experimental and Molecular Cardiology Group, University of Amsterdam, The Netherlands
Dev Biol 224:263-74. 2000....
- Abnormal cardiac conduction and morphogenesis in connexin40 and connexin43 double-deficient miceS Kirchhoff
Universitat Bonn, Institut fur Genetik, Abt Molekulargenetik, Bonn, Germany
Circ Res 87:399-405. 2000Connexin40-deficient (Cx40(-/-)/Cx43(+/+)) and connexin43-heterozygous knockout mice (Cx40(+/+)/Cx43(+/-)) are viable but show cardiac conduction abnormalities...
- Null mutation of connexin43 causes slow propagation of ventricular activation in the late stages of mouse embryonic developmentD Vaidya
Department of Pharmacology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
Circ Res 88:1196-202. 2001..3 [7.8 to 8.9], and Cx43(-/-) 1.7 [1.3 to 2.1; P<0.005]) corresponding with the downregulation of Cx40. Cx40 and Cx45 mRNAs were detectable in ventricular homogenates even at 17...
- A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and diseaseB G Bruneau
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Cell 106:709-21. 2001..Surprisingly, Tbx5 haploinsufficiency also markedly decreased atrial natriuretic factor (ANF) and connexin 40 (cx40) transcription, implicating these as Tbx5 target genes and providing a mechanism by which 50% reduction ..
- Vascular abnormalities in mice lacking the endothelial gap junction proteins connexin37 and connexin40Alexander M Simon
Department of Physiology, University of Arizona, Tucson, 85724, USA
Dev Biol 251:206-20. 2002..Mice lacking either connexin37 (Cx37) or connexin40 (Cx40), the predominant gap junction proteins present in vascular endothelium, are viable and exhibit phenotypes that are ..
- Comparison of connexin expression patterns in the developing mouse heart and human foetal heartSteven R Coppen
Cardiac Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College, Royal Brompton Hospital, London, UK
Mol Cell Biochem 242:121-7. 2003..The expression of the three major connexins (Cx43, Cx40 and Cx45) present in cardiac myocytes is known to be developmentally regulated but it is not clear how the patterns ..
- Spatiotemporal pattern of commitment to slowed proliferation in the embryonic mouse heart indicates progressive differentiation of the cardiac conduction systemDavid Sedmera
Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Anat Rec A Discov Mol Cell Evol Biol 274:773-7. 2003..5-13.5. These patterns of slowed proliferation correlate well with those in other species, and can serve as a useful marker for the forming conduction system...
- Architectural and functional asymmetry of the His-Purkinje system of the murine heartLucile Miquerol
Laboratoire de Genetique et Physiologie du Developpement, UMR 6545, Institut de Biologie du Developpement de Marseille, Universite de la Mediterranee, France
Cardiovasc Res 63:77-86. 2004..The aim of this work was to target a vital reporter gene in the mouse cardiac conduction system (CS) to distinguish this tissue from the surrounding myocardium in the adult heart...
- Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heartKazuko Koshiba-Takeuchi
Programs in Cardiovascular Research, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
Nat Genet 38:175-83. 2006..Thus, a positive and negative feed-forward circuit between Tbx5 and Sall4 ensures precise patterning of embryonic limb and heart and provides a unifying mechanism for heart/hand syndromes...
- Formation of the venous pole of the heart from an Nkx2-5-negative precursor population requires Tbx18Vincent M Christoffels
Department of Experimental and Molecular Cardiology Group, Academic Medical Center, Amsterdam, The Netherlands
Circ Res 98:1555-63. 2006....
- Molecular pathway for the localized formation of the sinoatrial nodeMathilda T M Mommersteeg
Center for Heart Failure Research, Academic Medical Centre, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
Circ Res 100:354-62. 2007....
- Targeted mutation reveals essential functions of the homeodomain transcription factor Shox2 in sinoatrial and pacemaking developmentRudiger J Blaschke
Human Genetics, University of Heidelberg, Heidelberg, Germany
Circulation 115:1830-8. 2007..Here, we report on a highly restricted expression pattern of the homeodomain transcription factor Shox2 in the sinus venosus myocardium, including the sinoatrial nodal region and the venous valves...
- Connexin37 and Connexin43 deficiencies in mice disrupt lymphatic valve development and result in lymphatic disorders including lymphedema and chylothoraxJohn D Kanady
Department of Physiology, University of Arizona, Tucson, AZ 85724, USA
Dev Biol 354:253-66. 2011..These results show that at least three Cxs are expressed in the developing lymphatic vasculature and, when defective, are associated with clinically manifest lymphatic disorders in mice and man...
- The effect of connexin40 deficiency on ventricular conduction system function during developmentBarbora Sankova
Department of Cardiovascular Morphogenesis, Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 14220 Prague, Czech Republic
Cardiovasc Res 95:469-79. 2012..The aim of this study was to characterize ventricular activation patterns in normal and connexin40-deficient mice in order to dissect the role of connexin40 in developing the conduction system...
- Tissue distribution and subcellular localization of the cardiac sodium channel during mouse heart developmentJorge N Domínguez
Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaen, Paraje de las Lagunillas, S N, Jaén 23071, Spain
Cardiovasc Res 78:45-52. 2008..The aim of this study was to analyse the mRNA expression levels and protein distribution of the cardiac sodium channel Scn5a/Nav1.5 during mouse cardiogenesis...
- Differential expression of the gap junction proteins connexin45, -43, -40, -31, and -26 in mouse skinA Butterweck
Abt Molekulargenetik der Universität, Bonn Germany
Eur J Cell Biol 65:152-63. 1994..and -31 were located similarly as in embryonic tissue, but Cx45 as well as Cx26 were not detected and in addition Cx40 was weakly expressed in the stratum basale...
- Impaired conduction of vasodilation along arterioles in connexin40-deficient miceC de Wit
Physiologisches Institut, Ludwig Maximilians Universitat Munchen, Munchen, Germany
Circ Res 86:649-55. 2000..transmission of vasomotor responses in the intact skeletal muscle microcirculation of connexin40-deficient mice (Cx40(-/-))...
- Comparison of connexin 43, 40 and 45 expression patterns in the developing human and mouse heartsR A Kaba
Cardiac Medicine, National Heart and Lung Institute, Imperial College, London, United Kingdom
Cell Commun Adhes 8:339-43. 2001..In general, these dynamic changes of connexins 43, 40 and 45 during mouse cardiac development appear to be mirrored in the human...
- Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac functionMei Xin
Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 104:7975-80. 2007..These findings reveal a ventricular myocardial cell-autonomous function for Hrt2 in the suppression of atrial cell identity and the maintenance of postnatal cardiac function...
- Increased expression of renal cyclooxygenase-2 and neuronal nitric oxide synthase in hypertensive Cx40-deficient miceNathalie Krattinger
Department of Medicine, University Hospital, Lausanne, Switzerland
J Vasc Res 46:188-98. 2009b>Cx40-deficient mice (Cx40-/-) are hypertensive due to increased renin secretion. We evaluated the renal expression of neuronal nitric oxide synthase (nNOS) and cyclooxygenases COX-1 and COX-2, three macula densa enzymes...
- Connexin expression in renin-producing cellsLisa Kurtz
Institute of Physiology, University of Regensburg, Regensburg, Germany
J Am Soc Nephrol 20:506-12. 2009Absence of connexin 40 (Cx40) leads to ectopic juxtaglomerular renin expression and abrogates recruitment of renin-expressing cells in the adult kidney but does not disturb renin expression during kidney development...
- Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathyGuillermo Luxan
Program of Cardiovascular Developmental Biology, Department of Cardiovascular Development and Repair, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain
Nat Med 19:193-201. 2013..These results implicate NOTCH signaling in LVNC and indicate that MIB1 mutations arrest chamber myocardium development, preventing trabecular maturation and compaction...
- The short stature homeobox 2 (Shox2)-bone morphogenetic protein (BMP) pathway regulates dorsal mesenchymal protrusion development and its temporary function as a pacemaker during cardiogenesisCheng Sun
From the Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118
J Biol Chem 290:2007-23. 2015..to increased apoptosis, accompanied by dramatically reduced expression of Bmp4 and Hcn4, ectopic activation of Cx40, and an aberrant pattern of action potentials...
- Genetic diseases and gene knockouts reveal diverse connexin functionsT W White
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Annu Rev Physiol 61:283-310. 1999..In addition, gene targeting of connexins in mice has provided new insights into connexin function and the significance of connexin diversity...
- Connexin40-deficient mice exhibit atrioventricular nodal and infra-Hisian conduction abnormalitiesB A VanderBrink
Cardiac Arrhythmia Service, New England Medical Center, Boston, Massachusetts 02111, USA
J Cardiovasc Electrophysiol 11:1270-6. 2000Previous electrophysiologic investigations have described AV conduction disturbances in connexin40 (Cx40)-deficient mice...
- Altered dye diffusion and upregulation of connexin37 in mouse aortic endothelium deficient in connexin40Olaf Krüger
Institut fur Genetik, Abteilung Molekulargenetik, Universitat Bonn, Deutschland
J Vasc Res 39:160-72. 2002Connexin40 (Cx40), connexin37 (Cx37) and connexin43 (Cx43) are subunit proteins of gap junction channels in the vascular wall which are presumably involved in the propagation of vasomotor signals...
- The transcriptional repressor Tbx3 delineates the developing central conduction system of the heartWillem M H Hoogaars
Experimental and Molecular Cardiology Group, AMC, University of Amsterdam, Amsterdam, The Netherlands
Cardiovasc Res 62:489-99. 2004..We studied the developmental expression pattern and functional aspects of the T-box transcription factor Tbx3, a novel marker for the murine central conduction system (CCS)...
- Temporal and spatial expression pattern of beta1 sodium channel subunit during heart developmentJorge N Domínguez
Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaen, Paraje de las Lagunillas, S N, 23071 Jaen, Spain
Cardiovasc Res 65:842-50. 2005..The aim of this study is to analyze Scn1b mRNA expression levels and protein distribution of Scn1b, a putative modulator of the pore-forming Na(+) channel subunit in the heart, during mouse cardiac development...
- Connexin40 and connexin43 in mouse aortic endothelium: evidence for coordinated regulationBrant E Isakson
Department of Molecular Physiology and Biological Physics, Robert M Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
Am J Physiol Heart Circ Physiol 290:H1199-205. 2006..To reveal a possible interaction between connexin40 (Cx40) and connexin43 (Cx43) in endothelium, we studied their distribution in vessels from C57Bl/6 and Cx40 knockout mice ..
- Reduced gap junctional coupling leads to uncorrelated motor neuron firing and precocious neuromuscular synapse eliminationKirkwood E Personius
Department of Rehabilitation Science, School of Public Health and Health Professions, University at Buffalo, The State University of New York, Buffalo, NY 14214 3079, USA
Proc Natl Acad Sci U S A 104:11808-13. 2007..motor neuron activity that, in turn, modulates neuromuscular synapse elimination, by using mutant mice lacking connexin 40 (Cx40), a developmentally regulated gap junction protein expressed in motor and other spinal neurons...
- Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeabilityChristopher A Jones
Department of Oncological Sciences, University of Utah, 15 North 2030 East, Salt Lake City, Utah 84112, USA
Nat Med 14:448-53. 2008....
- Downregulation of connexin40 is associated with coronary endothelial cell dysfunction in streptozotocin-induced diabetic miceAyako Makino
Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, CA 92093 0618, USA
Am J Physiol Cell Physiol 295:C221-30. 2008..Coronary ECs isolated from diabetic mice exhibit lowered protein levels of Cx37 and Cx40 (but not Cx43) and a loss of gap junction intercellular communication (GJIC)...
- The del22q11.2 candidate gene Tbx1 controls regional outflow tract identity and coronary artery patterningMagali Théveniau-Ruissy
Developmental Biology Institute of Marseilles Luminy, Inserm Avenir Group, UMR 6216 CNRS Université de la Méditerrané, Campus de Luminy, Marseille Cedex 9, France
Circ Res 103:142-8. 2008..Our results implicate second heart field development in coronary artery patterning and provide new insights into the association between conotruncal defects and coronary artery anomalies...
- Connexin 30 is expressed in the mouse sino-atrial node and modulates heart rateDaniel Gros
Institut de Biologie du Developpement de Marseille Luminy, Universite de la Mediterranee, Marseille, France
Cardiovasc Res 85:45-55. 2010..This study aimed at characterizing expression and the functional role of the Gjb6 gene, encoding for connexin 30 (Cx30) protein, in the adult mouse heart...
- Neuregulin 1 sustains the gene regulatory network in both trabecular and nontrabecular myocardiumDonna Lai
Victor Chang Cardiac Research Institute, Lowy Packer Building, 405 Liverpool St, Darlinghurst 2010, Australia
Circ Res 107:715-27. 2010..In development, the membrane-tethered signaling ligand Neuregulin (Nrg)1, expressed in endocardium, is essential for ventricular morphogenesis. In adults, Nrg1 protects against heart failure and can induce cardiomyocytes to divide...
- Loss of connexin40 is associated with decreased endothelium-dependent relaxations and eNOS levels in the mouse aortaFlorian Alonso
Service of Internal Medicine, Laboratory of Experimental Medicine 19 135S, University Hospital, CHUV, Lausanne, Switzerland
Am J Physiol Heart Circ Physiol 299:H1365-73. 2010..Endothelial cells of mouse aorta are interconnected by gap junctions made of connexin40 (Cx40) and connexin37 (Cx37), allowing the exchange of signaling molecules to coordinate their activity...
- Remodeling of the peripheral cardiac conduction system in response to pressure overloadBrett S Harris
Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Am J Physiol Heart Circ Physiol 302:H1712-25. 2012..PCS cardiomyocytes showed a 98% increase in the number of Cx40-positive gap junction particles, with an associated twofold increase in gene expression (P < 0.05)...
- Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia modelsBrunella Cristofaro
CIRB College de France, Inserm U1050 CNRS UMR 7241, Paris, France
Development 140:1720-9. 2013....
- Functional suppression of Kcnq1 leads to early sodium channel remodelling and cardiac conduction system dysmorphogenesisAngel J De La Rosa
Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaen, Paraje de Lagunillas, S N, Jaén 23071, Spain
Cardiovasc Res 98:504-14. 2013....
- The Connexin40A96S mutation from a patient with atrial fibrillation causes decreased atrial conduction velocities and sustained episodes of induced atrial fibrillation in miceIndra Lübkemeier
Life and Medical Sciences LIMES Institute, Molecular Genetics, University of Bonn, Bonn, Germany
J Mol Cell Cardiol 65:19-32. 2013..In the mammalian heart the gap junction proteins connexin40 (Cx40) and connexin43 (Cx43) are strongly expressed in the atrial myocardium mediating effective propagation of ..
- Cardiac arrhythmia induced by genetic silencing of 'funny' (f) channels is rescued by GIRK4 inactivationPietro Mesirca
1 Département de Physiologie, Institut de Genomique Fonctionnelle, LabEx ICST, F 34094 Montpellier, France 2 UMR 5203, Centre National de la Recherche Scientifique, Universités de Montpellier 1 and 2, F 34094 Montpellier, France 3 INSERM U661, Universités de Montpellier 1 and 2, F 34094 Montpellier, France
Nat Commun 5:4664. 2014....
- Inducible deletion of connexin 40 in adult mice causes hypertension and disrupts pressure control of renin secretionMelanie Gerl
Department of Physiology, University of Regensburg, Regensburg, Germany
Kidney Int 87:557-63. 2015Genetic loss-of-function defects of connexin 40 in renal juxtaglomerular cells are associated with renin-dependent hypertension...
- Wnt4 is essential to normal mammalian lung developmentArianna Caprioli
Dept of Biology and Physical Sciences, Marymount Univ, 2807 N Glebe Rd, Arlington, VA 22207, USA
Dev Biol 406:222-34. 2015..Together, these data reveal a previously unknown role for the secreted protein Wnt4 in respiratory system development. ..
- Interaction Between ALK1 Signaling and Connexin40 in the Development of Arteriovenous MalformationsKonstantinos Gkatzis
From the Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands K G, C L M CNRS Unité mixte de recherche 7241 INSERM U1050, Center for Interdisciplinary Research in Biology, College de France, Paris Cedex 05, France J T, D D S L, S M, N L, F L MEMOLIFE Laboratory of Excellence, Paris Sciences et Lettres Research University, Paris, France J T, D D S L, S M, N L, F L Department of Radiology, AP HP, Tenon Hospital, Paris, France M F C Sorbonne Universités, UPMC University, Paris, France M F C St Antonius Hospital, Nieuwegein, The Netherlands F D, R J S, C J W, J J M Department of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville S P O Aix Marseille Université, CNRS IBDM UMR 7288, NJ 08543
Arterioscler Thromb Vasc Biol 36:707-17. 2016To determine the role of Gja5 that encodes for the gap junction protein connexin40 in the generation of arteriovenous malformations in the hereditary hemorrhagic telangiectasia type 2 (HHT2) mouse model.
- A novel conditional mouse model for Nkx2-5 reveals transcriptional regulation of cardiac ion channelsMilena B Furtado
Australian Regenerative Medicine Institute, Monash University, Clayton, VIC 3800, Australia The Jackson Laboratory, ME 04609, United States
Differentiation 91:29-41. 2016....
- Segregated Foxc2, NFATc1 and Connexin expression at normal developing venous valves, and Connexin-specific differences in the valve phenotypes of Cx37, Cx43, and Cx47 knockout miceStephanie J Munger
Department of Physiology, University of Arizona, Tucson, AZ 85724, USA Electronic address
Dev Biol 412:173-90. 2016..The partition of Foxc2 and NFATc1 expression at VV leaflets makes it unlikely that these factors directly cooperate during the leaflet elongation stage of VV development. ..
- Pitx2 confers left morphological, molecular, and functional identity to the sinus venosus myocardiumGrazia Ammirabile
CNR Institute of Neurosciences, Department of Biomedical Sciences, University of Padova, Viale G Colombo 3, Padova 35121, Italy
Cardiovasc Res 93:291-301. 2012..The role of the laterality gene Pitx2 in this process is unknown. We aimed to elucidate the molecular events driving left/right patterning in the sinus venosus (SV) myocardium by using a myocardial Pitx2 knockout mouse...
- Role of connexin40 in the autoregulatory response of the afferent arterioleCharlotte Mehlin Sorensen
Institute of Biomedical Sciences, Division of Renal and Vascular Physiology, University of Copenhagen, Denmark
Am J Physiol Renal Physiol 303:F855-63. 2012..Connexin40 (Cx40) also plays a significant role in the regulation of renin secretion...
- Defective Cx40 maintains Cx37 expression but intact Cx40 is crucial for conducted dilations irrespective of hypertensionAlexander Jobs
Institut fur Physiologie, Universitat zu Lubeck, Lubeck, Germany
Hypertension 60:1422-9. 2012The gap junction channel protein connexin40 (Cx40) is crucial in vascular and renal physiology, because Cx40-deficient mice exhibit impaired conduction of endothelium-dependent dilations and pronounced hypertension...
- Compromised regulation of tissue perfusion and arteriogenesis limit, in an AT1R-independent fashion, recovery of ischemic tissue in Cx40(-/-) miceJennifer S Fang
Department of Physiology, University of Arizona, Tucson, AZ 85718, USA
Am J Physiol Heart Circ Physiol 304:H816-27. 2013..hindlimb was reduced, inflammatory response increased, and survival of distal limb tissue compromised in connexin 40 (Cx40)-deficient (Cx40(-/-)) mice...
- The aldo-keto reductase AKR1B7 coexpresses with renin without influencing renin production and secretionKatharina Machura
Institut fur Physiologie, Universitat Regensburg, D 93053 Regensburg, Germany
Am J Physiol Renal Physiol 304:F578-84. 2013..In summary, our data suggest that AKR1B7 is not of major relevance for the regulation of renin production and secretion in spite of its striking coregulation with renin expression...
- Polymorphism in endothelial connexin40 enhances sensitivity to intraluminal pressure and increases arterial stiffnessDaniel J Chaston
John Curtin School of Medical Research, The Australian National University, Bldg 131 Garran Rd, Acton Australian Capital Territory 0200 Australia
Arterioscler Thromb Vasc Biol 33:962-70. 2013To determine whether impairment of endothelial connexin40 (Cx40), an effect that can occur in hypertension and aging, contributes to the arterial dysfunction and stiffening in these conditions.
- Gene and pseudogene of the mouse cation-dependent mannose 6-phosphate receptor. Genomic organization, expression, and chromosomal localizationT Ludwig
European Molecular Biology Laboratory, Heidelberg, Federal Republic of Germany
J Biol Chem 267:12211-9. 1992..Therefore, it may represent an additional exon of the functional gene. These two features of the pseudogene suggest that expression of the CD-MPR gene may be regulated by use of different promoters and/or alternative splicing...
- The diversity of connexin genes encoding gap junctional proteinsK Willecke
Institut für Genetik Abt Molekulargenetik Universität, Bonn Bundersrepublik Deutschland
Eur J Cell Biol 56:1-7. 1991..The structural diversity of the connexin genes suggests that they fulfill different functions coordinated with, and perhaps required for, different programs of cellular differentiation...
- Characterization of the mouse loricrin gene: linkage with profilaggrin and the flaky tail and soft coat mutant loci on chromosome 3J A Rothnagel
Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030
Genomics 23:450-6. 1994..These mouse mutants exhibit a number of changes in their integument, suggesting that abnormalities in these genes may contribute to the mutant phenotype...
- Developmental regulation of connexin 40 gene expression in mouse heart correlates with the differentiation of the conduction systemB Delorme
Laboratoire de Genetique et Physiologie du Developpement, Institut de Biologie du Developpement de Marseille, Faculte des Sciences de Luminy, Universite de la Mediterranee, France
Dev Dyn 204:358-71. 1995In adult mouse heart, CX40 is expressed in the atria and the proximal part of the ventricular conduction system (the His bundle and the upper parts of the bundle branches)...
- Multiple members of the connexin gene family participate in preimplantation development of the mouseT C Davies
Department of Zoology, University of Western Ontario, London, Canada
Dev Genet 18:234-43. 1996..3, Cx31.1, and Cx40 mRNAs accumulate beginning in the eight-cell stage...
- Incompatibility of connexin 40 and 43 Hemichannels in gap junctions between mammalian cells is determined by intracellular domainsS Haubrich
Abteilung Molekulargenetik, University of Bonn, Germany
Mol Biol Cell 7:1995-2006. 1996Murine connexin 40 (Cx40) and connexin 43 (Cx43) do not form functional heterotypic gap junction channels...
- Heart defects in connexin43-deficient miceJ Ya
Department of Anatomy and Embryology, Academic Medical Center, University of Amsterdam, The Netherlands
Circ Res 82:360-6. 1998....
- Reduced cardiac conduction velocity and predisposition to arrhythmias in connexin40-deficient miceS Kirchhoff
Institut für Genetik Abt Molekulargenetik, Universitat Bonn, Römerstr 164, 53117, Bonn, Germany
Curr Biol 8:299-302. 1998..In the mouse, connexin40 (Cx40) protein has been detected in endothelial cells of lung and heart and in certain heart muscle cells: atrial ..
- Transplacental uptake of glucose is decreased in embryonic lethal connexin26-deficient miceH D Gabriel
Institut fur Genetik, Abt Molekulargenetik, Universitat Bonn, 53117 Bonn, Germany
J Cell Biol 140:1453-61. 1998....
- Conduction disturbances and increased atrial vulnerability in Connexin40-deficient mice analyzed by transesophageal stimulationA Hagendorff
Department of Cardiology, Institute of Genetics, University of Bonn, Germany
Circulation 99:1508-15. 1999Recently, it has been reported that connexin40 (Cx40) deficiency in targeted mouse mutants is associated with a prolongation of P-wave and QRS complex duration on surface electrograms...
- Cardiac conduction abnormalities in mice lacking the gap junction protein connexin40S Verheule
Department of Medical Physiology and Sports Medicine, Utrecht University, The Netherlands
J Cardiovasc Electrophysiol 10:1380-9. 1999The gap junction protein connexin40 (Cx40) normally is expressed in the murine atrial myocardium and ventricular conduction system. In mice lacking Cx40, several changes in the surface ECG have been described...
- Connexins and impulse propagation in the mouse heartJ Jalife
Department of Pharmacology, SUNY Health Science Center, Syracuse, New York 13210, USA
J Cardiovasc Electrophysiol 10:1649-63. 1999..Three gap junction proteins, known as connexins, are expressed in the heart: Cx40, Cx43, and Cx45...
- Connexin expression in the retinaG Sohl
Institut fur Genetik, Abteilung fur Molekulargenetik, Universitat Bonn, Germany
Brain Res Brain Res Rev 32:138-45. 2000..reactions of the corresponding antibodies, retinae from targeted connexin-deficient mice (Cx31 -/-, Cx32 -/- and Cx40 -/-) were used as negative controls for immunoblot and immunofluorescence analyses of wild-type retina...
- Unique and shared functions of different connexins in miceA Plum
Institut fur Genetik, Universitat Bonn, Roemerstrasse164, D 53117, Bonn, Germany
Curr Biol 10:1083-91. 2000..To discriminate between the unique and shared functions of Cx43, Cx40 and Cx32, we generated two 'knock-in' mouse lines, Cx43KI32 and Cx43KI40, in which the coding region of the Cx43 ..
- A novel genetic pathway for sudden cardiac death via defects in the transition between ventricular and conduction system cell lineagesV T Nguyêñ-Trân
UCSD Salk Program in Molecular Medicine and the UCSD Institute of Molecular Medicine, University of California, San Diego, La Jolla 92093, USA
Cell 102:671-82. 2000..These studies identify a novel genetic pathway for sudden cardiac death via defects in the transition between ventricular and conduction system cell lineages...
- Epaxial-adaxial-hypaxial regionalisation of the vertebrate somite: evidence for a somitic organiser and a mirror-image duplicationR Spörle
Institute of Mammalian Genetics, GSF Research Center for Environment and Health, Ingolstadter Landstrasse 1, 85764 Neuherberg, Germany
Dev Genes Evol 211:198-217. 2001....
- Functional significance of gap junctional coupling in preimplantation developmentF D Houghton
Department of Physiology, Dental Sciences Building, The University of Western Ontario, London, Ontario, Canada N6A 5C1
Biol Reprod 66:1403-12. 2002..New evidence of this diversification is presented using rat blastocyst outgrowths...
- Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formationPetra E M H Habets
Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Genes Dev 16:1234-46. 2002..5 on the ANF TBE-NKE, and was able to repress ANF promoter activity. Our data provide a potential mechanism for chamber-restricted gene activity in which the cooperative action of Tbx2 and Nkx2.5 inhibits expression in the AVC...
- Gap junctional connexins in the developing mouse cardiac conduction systemL Miquerol
Laboratoire de Génétique at Physiologie du Développement CNRS UMR 6545, Institut de Biologie du Developpement de Marseille, Universite de la Mediterranee, Marseille, France
Novartis Found Symp 250:80-98; discussion 98-109, 276-9. 2003..the conductive myocytes; Cx45 is weakly expressed in all conductive myocytes, including those of the nodal tissues; Cx40 expression is restricted to the atria and ventricular conduction system...
- Gap junctions in the inner ear: comparison of distribution patterns in different vertebrates and assessement of connexin composition in mammalsAndrew Forge
UCL Centre for Auditory Research and Institute of Laryngology and Otology, University College London, London WC1X 8EE, United Kingdom
J Comp Neurol 467:207-31. 2003..Heteromeric cx26/cx30 connexons may be unique to the inner ear, which could be one factor underlying the non-syndromic character of the deafness caused by mutations in cx26...
- Replacement of connexin40 by connexin45 in the mouse: impact on cardiac electrical conductionSébastien Alcoléa
Laboratoire de Genetique et Physiologie du Developpement, UMR CNRS 6545, Institut de Biologie du Developpement de Marseille, Universite de la Mediterranee, Marseille, France
Circ Res 94:100-9. 2004..Cx43, Cx40, and Cx45 are synthesized in the cardiomyocytes, and each of them has a unique cardiac expression pattern...
- Sinoatrial node dysfunction and early unexpected death of mice with a defect of klotho gene expressionKyosuke Takeshita
Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Circulation 109:1776-82. 2004..Homozygous mutant mice with a defect of klotho gene expression (kl/kl) show multiple age-related disorders and premature death from unknown causes...
- T-box transcription factor Tbx2 represses differentiation and formation of the cardiac chambersVincent M Christoffels
Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Dev Dyn 229:763-70. 2004..protein expression in mouse hearts was found to be complementary to that of chamber myocardium-specific genes Nppa, Cx40, Cx43, and Chisel, and was conserved in human...
- An expression atlas of connexin genes in the mouseAnnalisa Buniello
Telethon Institute of Genetics and Medicine, Via P Castellino 111, 80131 Naples, Italy
Genomics 83:812-20. 2004....
- Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction systemPatrick Y Jay
Department of Cardiology, Children s Hospital, Boston, Massachusetts 02115, USA
J Clin Invest 113:1130-7. 2004..Postnatal conduction defects in Nkx2-5 mutation may result at least in part from a defect in the genetic program that governs the recruitment or retention of embryonic cardiac myocytes in the conduction system...
- Abnormal angiogenesis in Foxo1 (Fkhr)-deficient miceTatsuo Furuyama
Department of Molecular Genetics and Geriatric Research, National Institute for Longevity Sciences, Kumamoto University, Kumamoto 860 0811, Japan
J Biol Chem 279:34741-9. 2004..These results suggest that Foxo1 is essential to the ability of endothelial cells to respond properly to a high dose of VEGF, thereby playing a critical role in normal vascular development...
- mRNA expression pattern of multiple members of connexin gene family in normal and abnormal fetal gonads in mouseSubhash C Juneja
Department of Zoology, The University of Western Ontario, London, Canada
Indian J Physiol Pharmacol 47:147-56. 2003..5 dpc knockout (Cx43-/-) fetuses. The mRNA expression pattern of connexins (Cx26, Cx30.3, Cx31, Cx31.1, Cx32, Cx37, Cx40, Cx43, Cx45, Cx46 and Cx50) was analyzed by RT-PCR...
- The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction systemIvan P G Moskowitz
Department of Genetics, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02115, USA
Development 131:4107-16. 2004..Deficiencies in the gap junction protein gene connexin 40 (Cx40), a downstream target of Tbx5, did not account for morphologic conduction system defects in Tbx5(del/+) ..
- The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent mannerDavid G McFadden
Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
Development 132:189-201. 2005..These findings demonstrate that Hand factors play pivotal and partially redundant roles in cardiac morphogenesis, cardiomyocyte differentiation and cardiac-specific transcription...
- Discontinuous conduction in mouse bundle branches is caused by bundle-branch architectureToon A B van Veen
Department of Medical Physiology, University Medical Center Utrecht, Utrecht, The Netherlands
Circulation 112:2235-44. 2005..The present study was performed to elucidate the mechanism responsible for this slowing of conduction...
- Left and right ventricular contributions to the formation of the interventricular septum in the mouse heartDiego Franco
Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaen, 23071 Jaen, Spain
Dev Biol 294:366-75. 2006..Examination of the orientation as well as the distribution of labeled cells in clusters provides new insights into the morphogenesis of the septum...
- Endogenous and exogenous NO attenuates conduction of vasoconstrictions along arterioles in the microcirculationBarbara Rodenwaldt
Physiologisches Institut, Universitat Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
Am J Physiol Heart Circ Physiol 292:H2341-8. 2007..The effects of NO were comparable to those of wild-type animals in Cx40-deficient mice, which excludes Cx40 as a specific target of NO...
- Arrhythmia induced by spatiotemporal overexpression of calreticulin in the heartKiyoko Hattori
Department of Pediatrics, Graduate School of Medical Science, Kumamoto University, Japan
Mol Genet Metab 91:285-93. 2007..In addition, the protein level of connexin40 (Cx40), connexin43 (Cx43), components of gap junction, and myocyte-enhancer factor (MEF) 2C, a cardiac-specific ..
- Interplay between cystic fibrosis transmembrane regulator and gap junction channels made of connexins 45, 40, 32 and 50 expressed in oocytesBasilio A Kotsias
Department of Pharmacology and Physiology, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642 8711, USA
J Membr Biol 214:1-8. 2006..interaction between CFTR and gap junction channels, we coexpressed in Xenopus oocytes CFTR and either Cx45, Cx40, Cx32 or Cx50 and monitored junctional conductance (G (j)) and its sensitivity to transjunctional voltage (V (j)) ..
- Expression of connexins in embryonic mouse neocortical developmentCima Cina
Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
J Comp Neurol 504:298-313. 2007..Cx26, Cx36, Cx37, Cx43, and Cx45 were expressed in the developing cortex of mice, Cx30 and Cx32 were absent, while Cx40 was expressed at a very low level...
- Connexin45 cannot replace the function of connexin40 in conducting endothelium-dependent dilations along arteriolesStephanie E Wölfle
Institut fur Physiologie, Universitat zu Lubeck, Germany
Circ Res 101:1292-9. 2007..Gap junctions in arterioles are composed of different connexins (Cxs) (Cx40, Cx37, Cx45, Cx43), but it is unknown whether Cxs are interchangeable...
- Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failureJian Fu Chen
Carolina Cardiovascular Biology Center, Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, NC 27599, USA
Proc Natl Acad Sci U S A 105:2111-6. 2008..Together, our studies demonstrate essential roles for Dicer in cardiac contraction and indicate that miRNAs play critical roles in normal cardiac function and under pathological conditions...
- SALL1 truncated protein expression in Townes-Brocks syndrome leads to ectopic expression of downstream genesSusan M Kiefer
Research and Education Service Line, St Louis Veterans Administration Medical Center, U S Department of Veterans Affairs, St Louis, Missouri 63106, USA
Hum Mutat 29:1133-40. 2008..We propose a model for the pathogenesis of TBS in which truncated Sall1 protein causes derepression of Sall-responsive target genes...
- Separating genetic and hemodynamic defects in neuropilin 1 knockout embryosElizabeth A V Jones
Inserm U833, F 75005, Paris, France
Development 135:2479-88. 2008..and mutants and after culture in no-flow conditions showed down-regulation of the arterial marker genes connexin 40 and ephrin B2 related to the loss of Nrp1 function...
- Connexin40 imparts conduction heterogeneity to atrial tissueDavid E Leaf
Leon H Charney Division of Cardiology, New York University School of Medicine, New York, NY 10016, USA
Circ Res 103:1001-8. 2008..Connexin40 (Cx40) is an abundant gap junction protein that is expressed in atrial myocytes...
- In calcineurin-induced cardiac hypertrophy expression of Nav1.5, Cx40 and Cx43 is reduced by different mechanismsMarti F A Bierhuizen
Department of Medical Physiology, Division Heart and Lungs, University Medical Center Utrecht, Yalelaan 50, 3584 CM Utrecht, The Netherlands
J Mol Cell Cardiol 45:373-84. 2008Alterations in expression levels of Na(v)1.5, Cx43 and Cx40 have been frequently reported in cardiac disease and are associated with the development of arrhythmias, but little is known about the underlying molecular mechanisms...
- Tbx3 is required for outflow tract developmentKarim Mesbah
Developmental Biology Institute of Marseilles Luminy, France
Circ Res 103:743-50. 2008....
- Dissection of two Cx37-independent conducted vasodilator mechanisms by deletion of Cx40: electrotonic versus regenerative conductionXavier F Figueroa
Departamento de Ciencias Fisiologicas, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
Am J Physiol Heart Circ Physiol 295:H2001-7. 2008..Connexin40 is essential for the ACh-activated regenerative vasodilator mechanism. However, neither connexin40 nor connexin37 is indispensable for the electrotonic spread of hyperpolarizing signals...
- Formation of the sinus node head and differentiation of sinus node myocardium are independently regulated by Tbx18 and Tbx3Cornelia Wiese
Center for Heart Failure Research, Academic Medical Centre, Meibergdreef 15, 1105AZ Amsterdam, The Netherlands
Circ Res 104:388-97. 2009..In contrast, Tbx3-deficient embryos formed a morphologically normal SAN, which, however, aberrantly expressed Cx40 and other atrial genes, demonstrating that Tbx3 controls differentiation of SAN head and tail cardiomyocytes but ..
- Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5Ramón A Espinoza-Lewis
Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA
Dev Biol 327:376-85. 2009..Genetically, the lack of Tbx3 and Hcn4 expression, along with ectopic activation of Nppa, Cx40, and Nkx2-5 in the Shox2(-/-) SAN region, indicates a failure in SAN differentiation...
- Gap Junction Mediated Signaling and Vascular ResponsesAlexander M Simon; Fiscal Year: 2010..In the first specific aim, the role of Cx37 and Cx40 in vascular development and angiogenesis is investigated...
- CONTROL OF CONNEXIN TRANSPORT AND ASSEMBLYMichael Koval; Fiscal Year: 2004....
- INTERCELLULAR COMMUNICATION IN MICROVESSELSBrian Duling; Fiscal Year: 2004..Hypothesis 5 - Intercellular communication is mediated by multiple connexins Hypothesis 6- Gap junctional communication plays a role in the establishment of normal vasomotor tone ..
- Regulation of the Endothelial Cell GlycocalyxBrian Duling; Fiscal Year: 2008..The experiments offer the potential for understanding a new level of microvascular regulation, and for developing strategies to understand the intracellular signaling that leads to modification of the glycocalyx. ..
- Molecular determinants of lung barrier functionMichael Koval; Fiscal Year: 2009....