Gjb1

Summary

Gene Symbol: Gjb1
Description: gap junction protein, beta 1
Alias: Cnx32, Cx32, connexin-32, gap junction beta-1 protein, connexin 32, connexin-43, gap junction membrane channel protein beta 1
Species: mouse

Top Publications

  1. pmc Defective propagation of signals generated by sympathetic nerve stimulation in the liver of connexin32-deficient mice
    E Nelles
    Abteilung Molekulargenetik, Universitat Bonn, Germany
    Proc Natl Acad Sci U S A 93:9565-70. 1996
  2. ncbi Connexin32 gene mutations in X-linked dominant Charcot-Marie-Tooth disease (CMTX1)
    E A Janssen
    Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands
    Hum Genet 99:501-5. 1997
  3. ncbi Structural abnormalities and deficient maintenance of peripheral nerve myelin in mice lacking the gap junction protein connexin 32
    P Anzini
    Department of Neurobiology, Swiss Federal Institute of Technology, CH 8093 Zurich, Switzerland
    J Neurosci 17:4545-51. 1997
  4. ncbi High incidence of spontaneous and chemically induced liver tumors in mice deficient for connexin32
    A Temme
    Institut fur Genetik, Abt Molekulargenetik, Universitat Bonn, Römerstr 164, 53117 Bonn, Germany
    Curr Biol 7:713-6. 1997
  5. ncbi Diverse functions of vertebrate gap junctions
    A M Simon
    Dept of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Trends Cell Biol 8:477-83. 1998
  6. ncbi The effect of connexin32 null mutation on hepatocarcinogenesis in different mouse strains
    O Moennikes
    Institut fur Toxikologie, Wilhelmstrabetae 56, 72074 Tübingen and Institut für Genetik, Bonn, Germany
    Carcinogenesis 20:1379-82. 1999
  7. ncbi Connexin29 is uniquely distributed within myelinating glial cells of the central and peripheral nervous systems
    Bruce M Altevogt
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 22:6458-70. 2002
  8. ncbi Connexin 47 (Cx47)-deficient mice with enhanced green fluorescent protein reporter gene reveal predominant oligodendrocytic expression of Cx47 and display vacuolized myelin in the CNS
    Benjamin Odermatt
    Institut fur Genetik, Universitat Bonn, D 53117 Bonn, Germany
    J Neurosci 23:4549-59. 2003
  9. ncbi Connexins are critical for normal myelination in the CNS
    Daniela M Menichella
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 23:5963-73. 2003
  10. pmc Coupling of astrocyte connexins Cx26, Cx30, Cx43 to oligodendrocyte Cx29, Cx32, Cx47: Implications from normal and connexin32 knockout mice
    J I Nagy
    Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Glia 44:205-18. 2003

Scientific Experts

Detail Information

Publications127 found, 100 shown here

  1. pmc Defective propagation of signals generated by sympathetic nerve stimulation in the liver of connexin32-deficient mice
    E Nelles
    Abteilung Molekulargenetik, Universitat Bonn, Germany
    Proc Natl Acad Sci U S A 93:9565-70. 1996
    ..It is possible, however, that they may develop neurodegenerative symptoms at older age...
  2. ncbi Connexin32 gene mutations in X-linked dominant Charcot-Marie-Tooth disease (CMTX1)
    E A Janssen
    Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands
    Hum Genet 99:501-5. 1997
    ..The nucleotide changes resulted in seven amino-acid substitutions and one premature stop codon...
  3. ncbi Structural abnormalities and deficient maintenance of peripheral nerve myelin in mice lacking the gap junction protein connexin 32
    P Anzini
    Department of Neurobiology, Swiss Federal Institute of Technology, CH 8093 Zurich, Switzerland
    J Neurosci 17:4545-51. 1997
    Mutations affecting the connexin 32 (Cx32) gene are associated with the X-linked form of the hereditary peripheral neuropathy Charcot-Marie-Tooth disease (CMTX)...
  4. ncbi High incidence of spontaneous and chemically induced liver tumors in mice deficient for connexin32
    A Temme
    Institut fur Genetik, Abt Molekulargenetik, Universitat Bonn, Römerstr 164, 53117 Bonn, Germany
    Curr Biol 7:713-6. 1997
    ..We have previously shown that transgenic mice that lack connexin32 (Cx32), the major gap junction protein expressed in hepatocytes, express lower levels of a second hepatic gap junction ..
  5. ncbi Diverse functions of vertebrate gap junctions
    A M Simon
    Dept of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Trends Cell Biol 8:477-83. 1998
    ....
  6. ncbi The effect of connexin32 null mutation on hepatocarcinogenesis in different mouse strains
    O Moennikes
    Institut fur Toxikologie, Wilhelmstrabetae 56, 72074 Tübingen and Institut für Genetik, Bonn, Germany
    Carcinogenesis 20:1379-82. 1999
    Connexin32 (Cx32) is the major gap junctional protein in mouse liver...
  7. ncbi Connexin29 is uniquely distributed within myelinating glial cells of the central and peripheral nervous systems
    Bruce M Altevogt
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 22:6458-70. 2002
    Although both Schwann cells and oligodendrocytes express connexin32 (Cx32), the loss of this connexin causes demyelination only in the PNS...
  8. ncbi Connexin 47 (Cx47)-deficient mice with enhanced green fluorescent protein reporter gene reveal predominant oligodendrocytic expression of Cx47 and display vacuolized myelin in the CNS
    Benjamin Odermatt
    Institut fur Genetik, Universitat Bonn, D 53117 Bonn, Germany
    J Neurosci 23:4549-59. 2003
    ..Initial analyses of Cx32/Cx47-double-deficient mice showed that these mice developed an action tremor and died on average at 51 d after ..
  9. ncbi Connexins are critical for normal myelination in the CNS
    Daniela M Menichella
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 23:5963-73. 2003
    Mutations in Cx32, a gap-junction channel-forming protein, result in X-linked Charcot-Marie-Tooth disease, a demyelinating disease of the peripheral nervous system...
  10. pmc Coupling of astrocyte connexins Cx26, Cx30, Cx43 to oligodendrocyte Cx29, Cx32, Cx47: Implications from normal and connexin32 knockout mice
    J I Nagy
    Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Glia 44:205-18. 2003
    ..A/O) gap junctions contain multiple connexins (Cx), including Cx26, Cx30, and Cx43 on the astrocyte side, and Cx32, Cx29, and Cx47 on the oligodendrocyte side...
  11. ncbi Unique distributions of the gap junction proteins connexin29, connexin32, and connexin47 in oligodendrocytes
    Kleopas A Kleopa
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, USA
    Glia 47:346-57. 2004
    Oligodendrocytes of adult rodents express three different connexins: connexin29 (Cx29), Cx32, and Cx47...
  12. pmc Connexin-47 and connexin-32 in gap junctions of oligodendrocyte somata, myelin sheaths, paranodal loops and Schmidt-Lanterman incisures: implications for ionic homeostasis and potassium siphoning
    N Kamasawa
    Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523 1617, USA
    Neuroscience 136:65-86. 2005
    The subcellular distributions and co-associations of the gap junction-forming proteins connexin 47 and connexin 32 were investigated in oligodendrocytes of adult mouse and rat CNS...
  13. ncbi Genetic and physiological evidence that oligodendrocyte gap junctions contribute to spatial buffering of potassium released during neuronal activity
    Daniela M Menichella
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 26:10984-91. 2006
    Mice lacking the K+ channel Kir4.1 or both connexin32 (Cx32) and Cx47 exhibit myelin-associated vacuoles, raising the possibility that oligodendrocytes, and the connexins they express, contribute to recycling the K+ evolved during ..
  14. ncbi The gap junction protein connexin32 interacts with the Src homology 3/hook domain of discs large homolog 1
    Heather S Duffy
    Department of Pharmacology, Columbia University, New York, New York 10032, USA
    J Biol Chem 282:9789-96. 2007
    ..Here we describe studies indicating that Cx32 interacts with a PDZ-containing scaffolding protein, Dlgh1 (Discs Large homolog 1)...
  15. pmc Cx29 and Cx32, two connexins expressed by myelinating glia, do not interact and are functionally distinct
    Meejin Ahn
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6077, USA
    J Neurosci Res 86:992-1006. 2008
    In rodents, oligodendrocytes and myelinating Schwann cells express connexin32 (Cx32) and Cx29, which have different localizations in the two cell types...
  16. pmc Ablation of Cx47 in transgenic mice leads to the loss of MUPP1, ZONAB and multiple connexins at oligodendrocyte-astrocyte gap junctions
    Xinbo Li
    Department of Physiology, Faculty of Medicine, University of Manitoba, Manitoba, Canada
    Eur J Neurosci 28:1503-17. 2008
    Oligodendrocytes in CNS are linked to astrocytes by heterotypic gap junctions composed of Cx32 and Cx47 in oligodendrocytes and Cx30 and Cx43 in astrocytes. These gap junctions also harbour regulatory proteins, including ZO-1 and ZONAB...
  17. pmc Connexin32 mutations cause loss of function in Schwann cells and oligodendrocytes leading to PNS and CNS myelination defects
    Irene Sargiannidou
    Neuroscience Laboratory, The Cyprus Institute of Neurology and Genetics, 1683 Nicosia, Cyprus
    J Neurosci 29:4736-49. 2009
    ..Transgenic mice with the R75W mutation and all mutant animals with Gjb1-null background developed a progressive demyelinating peripheral neuropathy along with CNS myelination defects...
  18. doi Connexin43 in cardiomyocyte mitochondria contributes to mitochondrial potassium uptake
    Elisabet Miro-Casas
    Servicio de Cardiologia, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119, Barcelona 08035, Spain
    Cardiovasc Res 83:747-56. 2009
    ..Connexin43 is present at the inner membrane of cardiomyocyte mitochondria (mCx43), but its function remains unknown...
  19. doi Oligodendrocytes in mouse corpus callosum are coupled via gap junction channels formed by connexin47 and connexin32
    Marta Maglione
    Max Delbruck Center for Molecular Medicine, Cellular Neuroscience, 13092 Berlin, Germany
    Glia 58:1104-17. 2010
    ..Oligodendrocytes are known to express Cx47, Cx32 and Cx29, astrocytes Cx43 and Cx30. In Cx47-deficient mice, the number of coupled cells was reduced by 80%...
  20. doi Dynamic expression of Cx47 in mouse brain development and in the cuprizone model of myelin plasticity
    Rosalba Parenti
    Department of Physiological Science, University of Catania, V le A Doria, 6 95125 Catania, Italy
    Glia 58:1594-609. 2010
    ..Since the expression of Cx47 in developing oligodendrocytes preceded those of Cx32 and Cx29, a role of Cx47 in myelinogenesis was postulated...
  21. ncbi Molecular cloning of mouse connexins26 and -32: similar genomic organization but distinct promoter sequences of two gap junction genes
    H Hennemann
    Institut für Genetik Abt Molekulargenetik, Universität Bonn Germany
    Eur J Cell Biol 58:81-9. 1992
    ..The promoter region of the mouse Cx32 gene contains two putative binding sites for the transcription factor HNF-1 and consensus motifs for NF-1 as well ..
  22. ncbi Characterization of a murine gene expressed from the inactive X chromosome
    G Borsani
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030
    Nature 351:325-9. 1991
    ..Nucleotide sequence analysis indicates that Xist may be associated with a protein product. The similar map positions and expression patterns for Xist in mouse and man suggest that this gene may have a role in X inactivation...
  23. ncbi Murine chromosomal location of four class III POU transcription factors
    K B Avraham
    Mammalian Genetics Laboratory, NCI Frederick Cancer Research and Development Center, Maryland 21702
    Genomics 18:131-3. 1993
    ..Chromosomal mapping has demonstrated that the four genes are unlinked: Otf-6 is located on the distal region of chromosome 4, Otf-7 on the proximal region of chromosome 4, Otf-8 on chromosome 1, and Otf-9 on the X chromosome...
  24. ncbi Physical mapping of 2000 kb of the mouse X chromosome in the vicinity of the Xist locus
    P Cooper
    Section of Comparative Biology, MRC Clinical Research Centre, Harrow, United Kingdom
    Genomics 15:570-5. 1993
    ..The DXCrc177 and DXCrc318 loci, both defined by probes derived from linking clones, are associated with CpG-rich islands. The map provides a framework for the isolation of underlying sequences in the mouse X-inactivation center region...
  25. ncbi Genetic diseases and gene knockouts reveal diverse connexin functions
    T W White
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Physiol 61:283-310. 1999
    ..In addition, gene targeting of connexins in mice has provided new insights into connexin function and the significance of connexin diversity...
  26. ncbi Macrophage-related demyelination in peripheral nerves of mice deficient in the gap junction protein connexin 32
    Igor Kobsar
    Department of Neurology, Section of Developmental Neurobiology, University of Wurzburg, Josef Schneider Strasse 11, D 97080 Wurzburg, Germany
    Neurosci Lett 320:17-20. 2002
    Mice deficient in the gap junction protein connexin 32 (Cx32) develop a slowly progressing demyelinating neuropathy, with enlarged periaxonal collars, abnormal non-compacted myelin domains and axonal sprouts...
  27. ncbi WY-14,643-mediated promotion of hepatocarcinogenesis in connexin32-wild-type and connexin32-null mice
    Oliver Moennikes
    Institut fur Pharmakologie und Toxikologie, Abteilung Toxikologie, Universitat Tubingen, Wilhelmstr 56, D 72074 Tubingen, Germany
    Carcinogenesis 24:1561-5. 2003
    Connexin32 (Cx32) is the major gap junction forming protein in liver and lack of functional Cx32 enhances hepatocarcinogenesis...
  28. ncbi Exocrine specific expression of Connexin32 is dependent on the basic helix-loop-helix transcription factor Mist1
    J Michael Rukstalis
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907 1392, USA
    J Cell Sci 116:3315-25. 2003
    ..In pancreatic acini, the connexin26 (Cx26) and connexin32 (Cx32) proteins form functional channels that coordinate the secretion of digestive enzymes...
  29. ncbi The gap junction protein connexin32 is a mouse lung tumor suppressor
    Timothy J King
    Cancer Prevention Research Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, and Department of Pathobiology, University of Washington, Seattle, Washington, USA
    Cancer Res 64:7191-6. 2004
    ..Here, we show for the first time that a gap junction protein, connexin32 (Cx32), acts as a lung tumor suppressor in a mouse model...
  30. ncbi The effects of a dominant connexin32 mutant in myelinating Schwann cells
    Linda Jo Bone Jeng
    Cell and Molecular Biology Graduate Group, The University of Pennsylvania Medical Center, Philadelphia, PA 19104 6077, USA
    Mol Cell Neurosci 32:283-98. 2006
    Mutations in GJB1, the gene encoding the gap junction protein connexin32 (Cx32), cause X-linked Charcot-Marie-Tooth disease, an inherited demyelinating peripheral neuropathy...
  31. ncbi Relative contributions of connexins 40 and 43 to atrial impulse propagation in synthetic strands of neonatal and fetal murine cardiomyocytes
    Philippe Beauchamp
    Department of Physiology, University of Bern, Switzerland
    Circ Res 99:1216-24. 2006
    ....
  32. ncbi Oocyte-directed depletion of connexin43 using the Cre-LoxP system leads to subfertility in female mice
    Eran Gershon
    Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel
    Dev Biol 313:1-12. 2008
    ....
  33. doi Expression of connexin29 and 32 in the penumbra region after traumatic brain injury of mice
    Younghye Moon
    Department of Anatomy, Korea University College of Medicine, Seoul, Korea
    Neuroreport 21:1135-9. 2010
    ..We found that the expressions of two Cx family members, Cx29 and Cx32, were progressively increased in the sharp border of injury penumbra regions after cryotraumatic brain injury...
  34. pmc Asparagine 175 of connexin32 is a critical residue for docking and forming functional heterotypic gap junction channels with connexin26
    So Nakagawa
    Institute for Protein Research, Osaka University, Suita, Osaka, Japan
    J Biol Chem 286:19672-81. 2011
    ..bonds between E2 domains are conserved in a group of heterotypically compatible hemichannels, including Cx26 and Cx32 hemichannels...
  35. pmc Deletion of oligodendrocyte Cx32 and astrocyte Cx43 causes white matter vacuolation, astrocyte loss and early mortality
    Laura M Magnotti
    Department of Neurobiology, Harvard Medical School, 220 Longwood Ave, Boston, Massachusetts 02115, USA
    Glia 59:1064-74. 2011
    ..b>Cx32-Cx43 dKO animals develop white matter vacuolation without obvious ultrastructural abnormalities in myelin...
  36. doi Connexin32 can restore hearing in connexin26 deficient mice
    Joachim Degen
    Institute of Genetics, University of Bonn, 53117 Bonn, Germany
    Eur J Cell Biol 90:817-24. 2011
    ..Here we have studied the functional equivalence of Cx26 and connexin32 (Cx32) isoforms in the cochlea...
  37. doi Disruption of oligodendrocyte gap junctions in experimental autoimmune encephalomyelitis
    Kyriaki Markoullis
    Neuroscience Laboratory, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus
    Glia 60:1053-66. 2012
    ..of inflammatory demyelination affect oligodendrocyte GJs, we studied the expression of oligodendrocytic connexin32 (Cx32) and Cx47 and astrocytic Cx43 in the experimental autoimmune encephalomyelitis (EAE) mouse model of multiple ..
  38. pmc Autophagy modulates dynamics of connexins at the plasma membrane in a ubiquitin-dependent manner
    Eloy Bejarano
    Department of Development and Molecular Biology, Albert Einstein College of Medicine, New York, NY 10461, USA
    Mol Biol Cell 23:2156-69. 2012
    ..autophagic degradation of GJ connexins, we analyzed the changes undergone by the fraction of plasma membrane connexin 43 targeted for macroautophagy and the sequence of events that trigger this process...
  39. doi Connexin 36 is expressed in beta and connexins 26 and 32 in acinar cells at the end of the secondary transition of mouse pancreatic development and increase during fetal and perinatal life
    Elia Martha Pérez-Armendariz
    Departamento de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico, DF, Mexico
    Anat Rec (Hoboken) 295:980-90. 2012
    To identify when during fetal development connexins (Cxs) 26 (Cx26) 32 (Cx32), and 36 (Cx36) begin to be expressed, as well as to characterize their spatial distribution, real time polymerase chain reaction and immunolabeling studies were ..
  40. pmc Characterization of the structure and intermolecular interactions between the connexin 32 carboxyl-terminal domain and the protein partners synapse-associated protein 97 and calmodulin
    Kelly Stauch
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Biol Chem 287:27771-88. 2012
    In Schwann cells, connexin 32 (Cx32) can oligomerize to form intracellular gap junction channels facilitating a shorter pathway for metabolite diffusion across the layers of the myelin sheath...
  41. doi Linoleic acid induces opening of connexin26 hemichannels through a PI3K/Akt/Ca(2+)-dependent pathway
    Vania Figueroa
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Biochim Biophys Acta 1828:1169-79. 2013
    ..Since LA is an essential polyunsaturated fatty acid, its effect on HCs might be relevant to cell growth as well as to cellular functions of differentiated cells such as audition...
  42. pmc Protection of a ceramide synthase 2 null mouse from drug-induced liver injury: role of gap junction dysfunction and connexin 32 mislocalization
    Woo Jae Park
    From the Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 288:30904-16. 2013
    ..All of these drugs and chemicals require connexin (Cx) 32, a key gap junction protein, to induce hepatotoxicity. Cx32 was mislocalized to an intracellular location in hepatocytes from CerS2 null mice, which resulted in accelerated ..
  43. pmc CamKII inhibitors reduce mitotic instability, connexon anomalies and progression of the in vivo behavioral phenotype in transgenic animals expressing a mutated Gjb1 gene
    Saleh Mones
    Therapy of Genetic Disorders, Faculte de Medecine, EA 4263, Aix Marseille Université Marseille, France INSERM, UMR1062, Nutrition, Obesity and Risk of Thrombosis, Faculté de Médecine Marseille, France INRA, UMR1260, Faculté de Médecine Marseille, France
    Front Neurosci 8:151. 2014
    Mutation in the Gjb1 gene, coding for a connexin (Cx32), is associated with an inherited peripheral neuropathic disorder (X-linked Charcot-Marie-Tooth, CMTX)...
  44. doi Endothelial connexin 32 regulates tissue factor expression induced by inflammatory stimulation and direct cell-cell interaction with activated cells
    Takayuki Okamoto
    Department of Molecular Pathobiology and Cell Adhesion Biology, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Atherosclerosis 236:430-7. 2014
    ..ECs express the gap junction (GJ) proteins connexin32 (Cx32), Cx37, Cx40 and Cx43...
  45. doi Transgenic replacement of Cx32 in gap junction-deficient oligodendrocytes rescues the phenotype of a hypomyelinating leukodystrophy model
    Natasa Schiza
    Neuroscience Laboratory
    Hum Mol Genet 24:2049-64. 2015
    ..Recessive GJC2/Cx47 mutations cause Pelizaeus-Merzbacher-like disease, a hypomyelinating leukodystrophy, while GJB1/Cx32 mutations cause neuropathy and chronic or acute-transient encephalopathy syndromes...
  46. doi CSF-1-activated macrophages are target-directed and essential mediators of Schwann cell dedifferentiation and dysfunction in Cx32-deficient mice
    Janos Groh
    Department of Neurology, Developmental Neurobiology, University Hospital Wuerzburg, Wuerzburg
    Glia 63:977-86. 2015
    We investigated connexin 32 (Cx32)-deficient mice, a model for the X-linked form of Charcot-Marie-Tooth neuropathy (CMT1X), regarding the impact of low-grade inflammation on Schwann cell phenotype...
  47. pmc Activated immune response in an inherited leukodystrophy disease caused by the loss of oligodendrocyte gap junctions
    Sameh K Wasseff
    Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, 450 Stemmler Hall, 3450 Hamilton Walk, Philadelphia, PA USA 19104 6077 Electronic address
    Neurobiol Dis 82:86-98. 2015
    ..junction (GJ) coupling is a widespread and essential feature of the CNS, and is mediated by connexin47 (Cx47) and Cx32. Loss of function mutations affecting Cx47 results in a severe leukodystrophy, Pelizeus-Merzbacher-like disease (..
  48. pmc Cell-Surface and Secreted Isoforms of CSF-1 Exert Opposing Roles in Macrophage-Mediated Neural Damage in Cx32-Deficient Mice
    Janos Groh
    Department of Neurology, Developmental Neurobiology, University Hospital Wuerzburg, D 97080 Wuerzburg, Germany, and
    J Neurosci 36:1890-901. 2016
    ..These results further corroborate the important role of secondary inflammation in mouse models of CMT1 and might identify specific targets for therapeutic approaches to modulate innate immune reactions...
  49. doi Aberrant trafficking of a Leu89Pro connexin32 mutant associated with X-linked dominant Charcot-Marie-Tooth disease
    Yuwei Da
    a Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China
    Neurol Res 38:897-902. 2016
    To determine the functional abnormalities of the Leu89Pro mutation in connexin32 (CX32), which we have previously reported is present within an X-linked dominant Charcot-Marie-Tooth disease family...
  50. ncbi Background lesions during a 24-month observation period in connexin 32-deficient mice
    Isao Igarashi
    Medicinal Safety Research Laboratories, Daiichi Sankyo Co, Ltd, Fukuroi, Shizuoka, Japan
    J Vet Med Sci 75:207-10. 2013
    b>Connexin 32 (Cx32) is a major gap junction protein in the liver...
  51. doi Connexin47 protein phosphorylation and stability in oligodendrocytes depend on expression of Connexin43 protein in astrocytes
    Dennis May
    Life and Medical Sciences Institute, Molecular Genetics, University of Bonn, D 53115 Bonn, Germany
    J Neurosci 33:7985-96. 2013
    ..We generated Connexin32 (Cx32)-deficient mice with additional deletion of astrocytic Cx43 to explore the role of both connexins in panglial ..
  52. ncbi The hepatocyte-specific phenotype of murine liver cells correlates with high expression of connexin32 and connexin26 but very low expression of connexin43
    R Stutenkemper
    Institute für Genetik, Abteilung Molekulargenetik, Universitat Bonn, Germany
    Exp Cell Res 201:43-54. 1992
    ..Furthermore several dedifferentiated cell lines derived from rat or mouse liver and cultivated in serum-containing medium were found to express little connexin32 or connexin26 mRNA but relatively high levels of connexin43 mRNA...
  53. ncbi Connexin expression and gap junction communication compartments in the developing mouse limb
    D W Laird
    Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada
    Dev Dyn 195:153-61. 1992
    ..and confocal microscopy together with 3-dimensional reconstruction software to map the distribution of Cx43 and Cx32 in 11-14.5 days postcoitum (dpc) mouse limbs...
  54. ncbi Developmental regulation of gap junction gene expression during mouse embryonic development
    M Nishi
    Department of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, California 92037
    Dev Biol 146:117-30. 1991
    ..4) In an ES cell culture line, alpha 1 was the only gap junction gene product detected. This is consistent with the findings of alpha 1 expression in the embryonic inner cell mass region and in undifferentiated teratocarcinoma cells...
  55. ncbi Genomic organization and chromosomal localization of mouse Eplg2, a gene encoding a binding protein for the receptor tyrosine kinase elk
    F A Fletcher
    Immunex Research and Development Corporation, Seattle, Washington 98101
    Genomics 24:127-32. 1994
    ..The first intron comprises approximately 8.5 kb of the entire 12-kb genomic sequence. Eplg2 was mapped to the mouse X chromosome by interspecific backcross analysis and is tightly linked to the androgen receptor (Ar) locus...
  56. ncbi Differential control of connexin-32 and connexin-43 expression in thyroid epithelial cells: evidence for a direct relationship between connexin-32 expression and histiotypic morphogenesis
    Y Munari-Silem
    Institut National de la Santé et de la Recherche Médicale U 369, Faculte de Medecine A Carrel, Lyon, France
    Endocrinology 135:724-34. 1994
    ..The Cx gene transcription products were analyzed by Northern blot using specific complementary DNA probes for Cx26, Cx32, and Cx43...
  57. ncbi Coexpression of gap junction proteins in the cumulus-oocyte complex
    G Valdimarsson
    Department of Zoology, University of Western Ontario, London, Canada
    Mol Reprod Dev 36:7-15. 1993
    ..Transcripts of both connexin32 (Cx32) and connexin43 (Cx43) were detected by RT-PCR in both components of the COC...
  58. ncbi Multiple members of the connexin gene family participate in preimplantation development of the mouse
    T C Davies
    Department of Zoology, University of Western Ontario, London, Canada
    Dev Genet 18:234-43. 1996
    ..The expression of multiple connexin genes during this early period of embryogenesis (when there are only two distinct cell types) raises questions about the functional significance of connexin diversity in this context...
  59. ncbi A second alternative transcript of the gap junction gene connexin32 is expressed in murine Schwann cells and modulated in injured sciatic nerve
    G Sohl
    Abt Molekulargenetik, Universitat Bonn, Germany
    Eur J Cell Biol 69:267-75. 1996
    Four connexin32 (Cx32) cDNA clones isolated from a rat sciatic nerve cDNA library differ in the nucleotide sequence of their 5' untranslated region (UTR) from the corresponding Cx32 cDNA clones previously characterized from liver...
  60. pmc Transplacental uptake of glucose is decreased in embryonic lethal connexin26-deficient mice
    H D Gabriel
    Institut fur Genetik, Abt Molekulargenetik, Universitat Bonn, 53117 Bonn, Germany
    J Cell Biol 140:1453-61. 1998
    ....
  61. ncbi Doubly mutant mice, deficient in connexin32 and -43, show normal prenatal development of organs where the two gap junction proteins are expressed in the same cells
    F D Houghton
    Department of Physiology, University of Western Ontario, London, Canada
    Dev Genet 24:5-12. 1999
    ..In the present study, we have tested this hypothesis by interbreeding mice carrying null mutations in the genes (Gjb1 and Gja1) encoding connexin32 (beta 1 connexin) and connexin43 (alpha 1 connexin), respectively...
  62. ncbi Studies in transgenic mice indicate a loss of connexin32 function in X-linked Charcot-Marie-Tooth disease
    A Abel
    Neurogenetics Branch, National Institute of Neurologic Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1250, USA
    J Neuropathol Exp Neurol 58:702-10. 1999
    ..an inherited demyelinating neuropathy caused by mutations in the gene encoding the gap junction protein connexin32 (Cx32)...
  63. ncbi Gap junction proteins connexin32 and connexin43 partially acquire growth-suppressive function in HeLa cells by deletion of their C-terminal tails
    Y Omori
    Unit of Multistage Carcinogenesis, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Carcinogenesis 20:1913-8. 1999
    ..proteins is the length of the C-terminal cytoplasmic tail, Cx26 having almost no tail, while Cx43 and connexin32 (Cx32) have long and intermediate ones, respectively...
  64. ncbi X-linked Charcot-Marie-Tooth disease and connexin32
    K H Fischbeck
    Neurogenetics Branch, National Institute of Neurological Disease and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 883:36-41. 1999
    ..Studies in cell culture and in transgenic mice show that connexin32 mutations can cause a loss of channel function or a gain of toxic effects on myelinating Schwann cells or both, with resulting peripheral nerve degeneration...
  65. ncbi Strongly decreased gap junctional permeability to inositol 1,4, 5-trisphosphate in connexin32 deficient hepatocytes
    H Niessen
    Institut fur Genetik, Abteilung Molekulare Genetik, Universitat Bonn, Romerstrasse 164, 53117, Bonn, Germany
    FEBS Lett 466:112-4. 2000
    Livers from connexin32 (Cx32) deficient mice have been shown to be defective in hormonally induced glucose mobilization...
  66. ncbi Endogenous dopaminergic regulation of horizontal cell coupling in the mammalian retina
    S He
    Vision, Touch and Hearing Research Centre, University of Queensland, Australia
    J Comp Neurol 418:33-40. 2000
    ..It has been proposed that the gap junctional coupling between horizontal cells is mediated by connexin 32 (Cx32), but the pattern and dopaminergic regulation of horizontal cell coupling were unaffected in Cx32-..
  67. ncbi Connexin expression in the retina
    G Sohl
    Institut fur Genetik, Abteilung fur Molekulargenetik, Universitat Bonn, Germany
    Brain Res Brain Res Rev 32:138-45. 2000
    ..exclude cross reactions of the corresponding antibodies, retinae from targeted connexin-deficient mice (Cx31 -/-, Cx32 -/- and Cx40 -/-) were used as negative controls for immunoblot and immunofluorescence analyses of wild-type retina...
  68. ncbi Acute-phase response and circadian expression of connexin26 are not altered in connexin32-deficient mouse liver
    A Temme
    Abteilung Molekulargenetik, Institut fur Genetik, Universitat Bonn, Germany
    Cell Tissue Res 300:111-7. 2000
    In mouse hepatocytes, the gap junctional proteins connexin32 (Cx32) and connexin26 (Cx26) are expressed in the same gap junctional plaque. Expression of the major Cx32 protein is downregulated during liver regeneration and cholestasis...
  69. ncbi Unique and shared functions of different connexins in mice
    A Plum
    Institut fur Genetik, Universitat Bonn, Roemerstrasse164, D 53117, Bonn, Germany
    Curr Biol 10:1083-91. 2000
    ..To discriminate between the unique and shared functions of Cx43, Cx40 and Cx32, we generated two 'knock-in' mouse lines, Cx43KI32 and Cx43KI40, in which the coding region of the Cx43 gene was ..
  70. ncbi A new alternatively spliced transcript of the mouse connexin32 gene is expressed in embryonic stem cells, oocytes, and liver
    G Sohl
    Institut fur Genetik, Albeilung Molekulargenetik, Universitat Bonn, 53117 Bonn, Germany
    Exp Cell Res 266:177-86. 2001
    The rodent gap junction protein connexin32 (Cx32) is highly expressed in hepatocytes, less abundantly in Schwann cells and oligodendrocytes, and at low levels in the early mouse embryo...
  71. ncbi Involvement of gap junctions in tumor suppression: analysis of genetically-manipulated mice
    Y Omori
    Unit of Multistage Carcinogenesis, International Agency for Research on Cancer, 150, cours Albert Thomas, 69372 Cedex 08, Lyon, France
    Mutat Res 477:191-6. 2001
    ..We have previously found several mutant forms of connexin 32 (Cx32) to be able to inhibit, in a dominant-negative manner, gap junctional intercellular communication (GJIC) ..
  72. ncbi Role of gap junctions in fluid secretion of lacrimal glands
    Benjamin Walcott
    Department of Neurobiology and Behavior, State University of New York, Stony Brook, NY 11794, USA
    Am J Physiol Cell Physiol 282:C501-7. 2002
    In glands such as the liver and pancreas, gap junctions containing connexin 26 and 32 (Cx26 and Cx32, respectively) couple the secretory cells. Uncoupling these junctions compromises the secretory function of these glands...
  73. ncbi Cx32 formation and/or Cx32-mediated intercellular communication induces expression and function of tight junctions in hepatocytic cell line
    Takashi Kojima
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    Exp Cell Res 276:40-51. 2002
    ..To examine the exact role of gap junctions in regulating tight junctions, we transfected connexin 32 (Cx32), Cx26, or Cx43 cDNAs into immortalized mouse hepatocytes derived from Cx32-deficient mice and examined ..
  74. ncbi Morphology and morphometric investigation of hepatocellular preneoplastic lesions and neoplasms in connexin32-deficient mice
    Matthias Evert
    Institut fur Pathologie, Otto von Guericke Universitat, Magdeburg, Germany
    Carcinogenesis 23:697-703. 2002
    ..and the formation of preneoplastic foci and hepatocellular neoplasms in transgenic knockout mice, as Connexin32 (Cx32) is the major gap junction protein in the liver...
  75. ncbi Expression profiles of the connexin genes, Gjb1 and Gjb3, in the developing mouse cochlea
    Nuria Lopez-Bigas
    Genes and Disease Program, Centre de Regulacio Genomica, Barcelona, Spain
    Gene Expr Patterns 2:113-7. 2002
    ..of the connexins in the inner ear we have analyzed the gene expression profiles of two connexin genes, Gjb1 (connexin 32) and Gjb3 (connexin 31), by in situ hybridization during the mouse cochlea organogenesis, from early otocyst up ..
  76. ncbi Oligodendrocyte progenitor enrichment in the connexin32 null-mutant mouse
    Lysanne Melanson-Drapeau
    Neural Regeneration Laboratory, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, K1H 8M5 Canada
    J Neurosci 23:1759-68. 2003
    ....
  77. pmc Connexin29 and connexin32 at oligodendrocyte and astrocyte gap junctions and in myelin of the mouse central nervous system
    James I Nagy
    Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba R3E 3J7, Canada
    J Comp Neurol 464:356-70. 2003
    The cellular localization, relation to other glial connexins (Cx30, Cx32, and Cx43), and developmental expression of Cx29 were investigated in the mouse central nervous system (CNS) with an anti-Cx29 antibody...
  78. ncbi Expression profiles of the connexin genes, Gjb1 and Gjb3, in the developing mouse cochlea
    Nuria Lopez-Bigas
    Genes and Disease Program, Centre de Regulacio Genomica, Barcelona, Spain
    Mech Dev 119:S111-5. 2002
    ..of the connexins in the inner ear we have analyzed the gene expression profiles of two connexin genes, Gjb1 (connexin 32) and Gjb3 (connexin 31), by in situ hybridization during the mouse cochlea organogenesis, from early otocyst up ..
  79. ncbi Gap junctions in the inner ear: comparison of distribution patterns in different vertebrates and assessement of connexin composition in mammals
    Andrew Forge
    UCL Centre for Auditory Research and Institute of Laryngology and Otology, University College London, London WC1X 8EE, United Kingdom
    J Comp Neurol 467:207-31. 2003
    ..Heteromeric cx26/cx30 connexons may be unique to the inner ear, which could be one factor underlying the non-syndromic character of the deafness caused by mutations in cx26...
  80. ncbi Mist1 is necessary for the establishment of granule organization in serous exocrine cells of the gastrointestinal tract
    Charis L Johnson
    Department of Physiology and Pharmacology, University of Western Ontario, Child Health Research Institute, London, Ont, Canada N6C 2V5
    Mech Dev 121:261-72. 2004
    ..Therefore, we conclude that Mist1 is necessary for complete differentiation and maturation of serous exocrine cells through the combined regulation of several exocrine specific genes...
  81. ncbi Loss of connexin 26 in mammary epithelium during early but not during late pregnancy results in unscheduled apoptosis and impaired development
    Celine Bry
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Dev Biol 267:418-29. 2004
    ..In mammary tissue, Cx26 and Cx32 are present in the secretory epithelium and Cx43 is localized in the myoepithelium...
  82. ncbi An expression atlas of connexin genes in the mouse
    Annalisa Buniello
    Telethon Institute of Genetics and Medicine, Via P Castellino 111, 80131 Naples, Italy
    Genomics 83:812-20. 2004
    ....
  83. ncbi mRNA expression pattern of multiple members of connexin gene family in normal and abnormal fetal gonads in mouse
    Subhash C Juneja
    Department of Zoology, The University of Western Ontario, London, Canada
    Indian J Physiol Pharmacol 47:147-56. 2003
    ..Gap junctions play important roles in ovarian and testicular function. Connexin 43 (Cx43) knockout mouse is a model for developmentally impaired fetal gonads...
  84. ncbi Tight junction protein MAGI-1 is up-regulated by transfection with connexin 32 in an immortalized mouse hepatic cell line: cDNA microarray analysis
    Masaki Murata
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cell Tissue Res 319:341-7. 2005
    ..Recently, we found that Cx32 but not Cx26 was closely related to tight junctional proteins in primary cultured rat hepatocytes (Kojima et al...
  85. ncbi Prenylation-defective human connexin32 mutants are normally localized and function equivalently to wild-type connexin32 in myelinating Schwann cells
    Yan Huang
    Department of Neurology, The University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 25:7111-20. 2005
    Mutations in GJB1, the gene encoding the gap junction protein connexin32 (Cx32), cause the X-linked form of Charcot-Marie-Tooth disease, an inherited demyelinating neuropathy...
  86. ncbi Connexin29 is highly expressed in cochlear Schwann cells, and it is required for the normal development and function of the auditory nerve of mice
    Wenxue Tang
    Department of Otolaryngology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 26:1991-9. 2006
    ..Our findings demonstrated the requirement of Cx29 for normal cochlear functions and suggest that Cx29 is a new candidate gene for studying the auditory neuropathy...
  87. pmc Selectivity of connexin 43 channels is regulated through protein kinase C-dependent phosphorylation
    Jose F Ek-Vitorin
    Department of Physiology, University of Arizona, Tucson 85724, USA
    Circ Res 98:1498-505. 2006
    ..Our data suggest that the selectivity of gap junction channels at intercalated disks is increased early in ischemia...
  88. ncbi Connexin 43-mediated modulation of polarized cell movement and the directional migration of cardiac neural crest cells
    Xin Xu
    Laboratory of Developmental Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20850, USA
    Development 133:3629-39. 2006
    b>Connexin 43 knockout (Cx43alpha1KO) mice have conotruncal heart defects that are associated with a reduction in the abundance of cardiac neural crest cells (CNCs) targeted to the heart...
  89. ncbi Proliferation of adult sertoli cells following conditional knockout of the Gap junctional protein GJA1 (connexin 43) in mice
    Santhi Sridharan
    Department of Veterinary Biosciences, University of Illinois at Urbana Champaign, Urbana, Illinois 61802, USA
    Biol Reprod 76:804-12. 2007
    GJA1 (also known and referred to here as connexin 43 and abbreviated CX43) is the predominant testicular gap junction protein, and CX43 may regulate Sertoli cell maturation and spermatogenesis...
  90. ncbi A role for Connexin43 during neurodevelopment
    Amy E Wiencken-Barger
    Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA
    Glia 55:675-86. 2007
    ..In conclusion, neurodevelopment of Shuffler/Cx43 cKO mice is abnormal, and the observed cellular phenotype may explain behavioral disturbances seen in these animals as well as in humans carrying Cx43 mutations...
  91. ncbi Interplay between cystic fibrosis transmembrane regulator and gap junction channels made of connexins 45, 40, 32 and 50 expressed in oocytes
    Basilio A Kotsias
    Department of Pharmacology and Physiology, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642 8711, USA
    J Membr Biol 214:1-8. 2006
    ..interaction between CFTR and gap junction channels, we coexpressed in Xenopus oocytes CFTR and either Cx45, Cx40, Cx32 or Cx50 and monitored junctional conductance (G (j)) and its sensitivity to transjunctional voltage (V (j)) by the ..
  92. pmc Connexin 32 increases the proliferative response of Schwann cells to neuregulin-1 (Nrg1)
    Mona Freidin
    Department of Neurology, State University of New York Downstate at Brooklyn, Brooklyn NY 10021, USA
    Proc Natl Acad Sci U S A 106:3567-72. 2009
    b>Connexin 32 (Cx32), a gap junction protein, is found within the para-nodal region and Schmidt-Lanterman incisures of myelinating Schwann cells (SCs)...
  93. pmc Congenital hypomyelinating neuropathy with lethal conduction failure in mice carrying the Egr2 I268N mutation
    Robert H Baloh
    Department of Neurology, and Hope Center for Neurological Diseases, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 29:2312-21. 2009
    ....
  94. doi Impact of connexin32 deletion on E7 or RET/PTC3 oncogene-driven growth and neoplastic transformation of the thyroid gland
    Gaëlle Prost
    Institut National de Santé et de Recherche Médicale, UMR 664, Lyon F 69372, France
    Endocr Relat Cancer 16:873-84. 2009
    ..Using genetically modified mice, we previously found that Cx32 acts as a down-regulator of growth in normal thyroid gland...
  95. pmc Cx32 and Cx47 mediate oligodendrocyte:astrocyte and oligodendrocyte:oligodendrocyte gap junction coupling
    Sameh K Wasseff
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6077, USA
    Neurobiol Dis 42:506-13. 2011
    ..to be exclusively coupled to astrocytes (O:A coupling) via heterotypic gap junctions composed of Cx47:Cx43 and Cx32:Cx30...
  96. ncbi Six genes of the human connexin gene family coding for gap junctional proteins are assigned to four different human chromosomes
    K Willecke
    Institut für Genetik Abt Molekulargenetik Universität, Bonn Bundesrepublik Deutschland
    Eur J Cell Biol 53:275-80. 1990
    ..A pseudogene of connexin 43 that lacks an intron of the cx43 gene has been located on human chromosome 5...
  97. ncbi The murine interleukin-2 receptor gamma chain gene: organization, chromosomal localization and expression in the adult thymus
    J P DiSanto
    INSERM U132, Hopital Necker Enfants Malades, Institut Pasteur, Paris, France
    Eur J Immunol 24:3014-8. 1994
    ..Genomic clones for the murine IL-2R gamma will allow for further studies on the regulation and function of this gene in vivo...
  98. ncbi Molecular basis of common hereditary motor and sensory neuropathies in humans and in mouse models
    G J Snipes
    Department of Neurobiology, Stanford University School of Medicine, California 94305, USA
    Brain Pathol 5:233-47. 1995
    ....
  99. ncbi Physical mapping of connexin 32 (GJB1) and 43 (GJA1) genes to bovine chromosomes Xq22 and 9q15/16 by fluorescence in situ hybridization
    B Castiglioni
    Istituto per la Difesa e la Valorizzazione del Germoplasma Animale, CNR, Via Celoria 10, 20133 Milano, Italy
    Mamm Genome 7:634-5. 1996
  100. ncbi Connexin32-null mice develop demyelinating peripheral neuropathy
    S S Scherer
    Department of Neurology, University of Pennsylvania Medical Center, Philidelphia 19104 6077, USA
    Glia 24:8-20. 1998
    Mutations in the gene encoding the gap junction protein connexin32 (Cx32) cause X-linked Charcot-Marie-Tooth disease (CMTX), a common form of inherited demyelinating peripheral neuropathy...
  101. ncbi Electrophysiological properties of gap junction channels in hepatocytes isolated from connexin32-deficient and wild-type mice
    V Valiunas
    Department of Physiology, University of Bern, Buhlplatz 5, CH 3012 Bern, Switzerland
    Pflugers Arch 437:846-56. 1999
    Hepatocytes were isolated from wild-type and connexin32-deficient (Cx32-deficient) mice. Pairs of cells were chosen to study the electrical properties of gap junction channels using the dual voltage-clamp method...

Research Grants7

  1. Zeiss LSM 510 Laser Scanning Microscope
    JOHN RASH; Fiscal Year: 2002
    ..The DIC Board of Directors will meet bi-monthly to insure continued efficient scheduling and operation of the replacement confocal microscope, to consider future upgrades, and to establish or change DIC access policies. ..
  2. Gap Junctions and Connexins in Developing CNS
    JOHN RASH; Fiscal Year: 2005
    ....
  3. Connexins in Neuronal and Glial Gap Junctions in the Central Nervous System
    JOHN RASH; Fiscal Year: 2007
    ..abstract_text> ..
  4. BIOLOGICALLY BASED CANCER RISK ASSESSMENT FOR MIXTURES
    E Luebeck; Fiscal Year: 2001
    ..To evaluate the usefulness of the TEF approach we propose to analyze the Allegheny/non-Allegheny coke oven cohort data, as an example. ..
  5. MSM Scales of carcinogenesis: cells, crypts and cancer
    E Luebeck; Fiscal Year: 2007
    ..This includes consequences for cancer screening, early detection, and the testing of specific intervention and prevention strategies. [unreadable] [unreadable]..
  6. "Connexin-Dependent Transcriptomic Networks in Controlling the Heart Rhythm"
    DUMITRU ANDREI IACOBAS; Fiscal Year: 2010
    ..Our project has the unique feature of describing and quantifying the Cx40- and Cx43-dependent Gene Regulatory Networks of the heart rhythm, with the long term goal to open novel therapeutic horizons in cardiology. ..