Genomes and Genes
Gene Symbol: Gjb2
Description: gap junction protein, beta 2
Alias: AI325222, Cnx26, Cx26, Gjb-2, gap junction beta-2 protein, connexin-26, gap junction membrane channel protein beta 2
Publications101 found, 100 shown here
- Expression of connexins in the developing olfactory system of the mouseF Miragall
Institut fur Anatomie, Universitat Regensburg, Germany
J Comp Neurol 325:359-78. 1992..Moreover, our findings indicate that although expression of connexin43 in the olfactory system is developmentally regulated, it is not directly associated with the neuronal cell turnover of the olfactory epithelium...
- Differential expression of gap junction mRNAs and proteins in the developing murine kidney and in experimentally induced nephric mesenchymesK Sainio
Department of Pathology, University of Helsinki, Finland
Development 115:827-37. 1992The expression of three gap junction (GJ) proteins, alpha 1 (Cx43), beta 1 (Cx32), and beta 2 (Cx26), and their transcripts were examined during the ontogeny of the mouse and rat kidney...
- Aberrant expression of gap junction proteins (connexins) is associated with tumor progression during multistage mouse skin carcinogenesis in vivoY Kamibayashi
Department of Pathology, Sapporo Medical University School of Medicine, Japan
Carcinogenesis 16:1287-97. 1995..mouse skin carcinogenesis in vivo, we immunohistochemically and morphometrically analyzed the expression of connexin 26 (Cx26) and connexin 43 (Cx43) in papillomas, well-, moderately- and poorly-differentiated squamous cell ..
- Connexin expression and gap junctions in the mammary glandP Monaghan
Institute of Cancer Research, Haddow Laboratories, Sutton, Surrey, U K
Cell Biol Int 20:121-5. 1996..Analysis of connexin expression at the molecular level is now bringing new insights into the structure and function of gap junctions in a range of normal and pathological cell systems...
- Connexin 26 mutations in hereditary non-syndromic sensorineural deafnessD P Kelsell
Academic Department of Dermatology, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, UK
Nature 387:80-3. 1997..of autosomal dominant deafness and have identified a mutation in the gene encoding the gap-junction protein connexin 26 (Cx26) that segregates with the profound deafness in the family...
- Expression pattern of different gap junction connexins is related to embryo implantationR Grummer
Institute of Anatomy, University of Essen, Germany
Int J Dev Biol 40:361-7. 1996..b>cx26 is locally expressed in the uterine epithelium of the implantation chamber, cx43 in the surrounding decidua prior ..
- Transplacental uptake of glucose is decreased in embryonic lethal connexin26-deficient miceH D Gabriel
Institut fur Genetik, Abt Molekulargenetik, Universitat Bonn, 53117 Bonn, Germany
J Cell Biol 140:1453-61. 1998....
- Diverse functions of vertebrate gap junctionsA M Simon
Dept of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
Trends Cell Biol 8:477-83. 1998....
- Genetic diseases and gene knockouts reveal diverse connexin functionsT W White
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Annu Rev Physiol 61:283-310. 1999..In addition, gene targeting of connexins in mice has provided new insights into connexin function and the significance of connexin diversity...
- Targeted ablation of connexin26 in the inner ear epithelial gap junction network causes hearing impairment and cell deathMartine Cohen-Salmon
Unité de Génétique des Déficits Sensoriels, CNRS URA 1968, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
Curr Biol 12:1106-11. 2002Mutations in the gene encoding the gap junction protein connexin26 (Cx26) are responsible for the autosomal recessive isolated deafness, DFNB1, which accounts for half of the cases of prelingual profound hereditary deafness in Caucasian ..
- Gap junctions in the inner ear: comparison of distribution patterns in different vertebrates and assessement of connexin composition in mammalsAndrew Forge
UCL Centre for Auditory Research and Institute of Laryngology and Otology, University College London, London WC1X 8EE, United Kingdom
J Comp Neurol 467:207-31. 2003..in the mammalian inner ear by RT-PCR, Western blotting, and immunohistochemistry revealed four connexin isotypes, cx26, cx30, cx31, and cx43, in the cochlea and three, cx26, cx30, and cx43, in the vestibular organs...
- Loss of connexin 26 in mammary epithelium during early but not during late pregnancy results in unscheduled apoptosis and impaired developmentCeline Bry
Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Dev Biol 267:418-29. 2004..Gap junctions are intercellular channels that are formed by the protein family of connexins (Cxs). In mammary tissue, Cx26 and Cx32 are present in the secretory epithelium and Cx43 is localized in the myoepithelium...
- Altered permeability and modulatory character of connexin channels during mammary gland developmentDarren Locke
Department of Pharmacology and Physiology, UMDNJ, Newark, NJ 07101, USA
Exp Cell Res 298:643-60. 2004..Microarray study shows that the principal connexin isoform in epithelial cells during pregnancy is Cx26, up-regulated and persisting from the virgin. After parturition, there is rapid induction of Cx32...
- Gap junction-mediated intercellular biochemical coupling in cochlear supporting cells is required for normal cochlear functionsYanping Zhang
Department of Otolaryngology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322 3030, USA
Proc Natl Acad Sci U S A 102:15201-6. 2005Dysfunction of gap junctions (GJs) caused by mutations in connexin26 (Cx26) and Cx30 accounts for nearly half of all cases of hereditary nonsyndromic deafness cases...
- Postnatal development of the organ of Corti in dominant-negative Gjb2 transgenic miceA Inoshita
Department of Otorhinolaryngology, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
Neuroscience 156:1039-47. 2008..50%) of congenital bilateral nonsyndromic sensorineural deafness cases have been linked to mutations in the GJB2 coding for the connexin26...
- ATP release through connexin hemichannels and gap junction transfer of second messengers propagate Ca2+ signals across the inner earFabio Anselmi
Foundation for Advanced Biomedical Research, Venetian Institute of Molecular Medicine, 35129 Padua, Italy
Proc Natl Acad Sci U S A 105:18770-5. 2008..By contrast, Ca(2+) responses failed to propagate in cultures with defective expression of connexin 26 (Cx26) or Cx30...
- Coordinated control of connexin 26 and connexin 30 at the regulatory and functional level in the inner earSaida Ortolano
Venetian Institute of Molecular Medicine, Foundation for Advanced Biomedical Research, 35129 Padua, Italy
Proc Natl Acad Sci U S A 105:18776-81. 2008b>Connexin 26 (Cx26) and connexin 30 (Cx30) are encoded by two genes (GJB2 and GJB6, respectively) that are found within 50 kb in the same complex deafness locus, DFNB1...
- Targeted connexin26 ablation arrests postnatal development of the organ of CortiYunfeng Wang
Department of Otolaryngology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322 3030, USA
Biochem Biophys Res Commun 385:33-7. 2009Mutations in the gene coding for connexin26 (Cx26) is the most common cause of human nonsyndromic hereditary deafness...
- Connexin30 null and conditional connexin26 null mice display distinct pattern and time course of cellular degeneration in the cochleaYu Sun
Department of Otolaryngology, Emory University School of Medicine, Atlanta, GA 30322 3030, USA
J Comp Neurol 516:569-79. 2009Mutations in connexin26 (Cx26) and Cx30 are the most common cause of nonsyndromic inherited deafness in humans...
- Cochlear outer hair cells in a dominant-negative connexin26 mutant mouse preserve non-linear capacitance in spite of impaired distortion product otoacoustic emissionA Minekawa
Department of Otorhinolaryngology, Juntendo University School of Medicine, Tokyo, Japan
Neuroscience 164:1312-9. 2009..Transgenic mice were established carrying human Cx26 with the R75W mutation that was identified in a deaf family with autosomal dominant negative inheritance [Kudo T et ..
- The connexin26 S17F mouse mutant represents a model for the human hereditary keratitis-ichthyosis-deafness syndromeMelanie Schütz
Institut for Genetik, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
Hum Mol Genet 20:28-39. 2011Mutations in the GJB2 gene coding for connexin26 (Cx26) can cause a variety of deafness and hereditary hyperproliferative skin disorders in humans...
- Peripheral lymphangiogenesis in mice depends on ectodermal connexin-26 (Gjb2)Nikolai Dicke
Institute of Genetics, Division of Molecular Genetics, University of Bonn, 53117 Bonn, Germany
J Cell Sci 124:2806-15. 2011In order to study the specific function of connexin-26 (Cx26, also known as gap junction beta-2 protein; Gjb2), we generated knockin mice that expressed either a floxed lacZ reporter or, after Cre-mediated deletion, connexin-32 (Cx32)-..
- BAAV mediated GJB2 gene transfer restores gap junction coupling in cochlear organotypic cultures from deaf Cx26Sox10Cre miceGiulia Crispino
Fondazione per la Ricerca Biomedica Avanzata, Istituto Veneto di Medicina Molecolare, Padova, Italy
PLoS ONE 6:e23279. 2011..the expression and function of connexin26 and connexin30 from postnatal day 5 to adult age in double transgenic Cx26(Sox10Cre) mice, which we obtained by crossing connexin26 floxed mice with a deleter Sox10-Cre line...
- Cell degeneration is not a primary causer for Connexin26 (GJB2) deficiency associated hearing lossChun Liang
Department of Otolaryngology, University of Kentucky Medical School, Lexington, KY 40536, USA
Neurosci Lett 528:36-41. 2012Connexin26 (Cx26, GJB2) mutations can induce congenital deafness and are responsible for ∼50% of nonsyndromic hearing loss in children...
- Molecular cloning of mouse connexins26 and -32: similar genomic organization but distinct promoter sequences of two gap junction genesH Hennemann
Institut für Genetik Abt Molekulargenetik, Universität Bonn Germany
Eur J Cell Biol 58:81-9. 1992..The first exon of each gene is preceded by a TATA-less promoter region. The promoter of the mouse Cx26 gene has at least two transcription start sites and is located in a very GC-rich region which is reminiscent of ..
- Differential expression of the gap junction proteins connexin45, -43, -40, -31, and -26 in mouse skinA Butterweck
Abt Molekulargenetik der Universität, Bonn Germany
Eur J Cell Biol 65:152-63. 1994..In the epidermis of adult mice Cx43 and -31 were located similarly as in embryonic tissue, but Cx45 as well as Cx26 were not detected and in addition Cx40 was weakly expressed in the stratum basale...
- Changing patterns of gap junctional intercellular communication and connexin distribution in mouse epidermis and hair follicles during embryonic developmentR Choudhry
Department of Dermatology, University of Glasgow, Scotland
Dev Dyn 210:417-30. 1997....
- The effects of a mutant connexin 26 on epidermal differentiationGeorge Bakirtzis
Division of Cancer Sciences and Molecular Pathology, University of Glasgow, Glasgow, Scotland, United Kingdom
Cell Commun Adhes 10:359-64. 2003..inherited skin diseases, transgenic mice were produced that express the true Vohwinkel syndrome-associated mutant Cx26 (D66H), from a keratin 10 promoter, specifically in the suprabasal epidermal keratinocytes...
- Maternal Tgif is required for vascularization of the embryonic placentaLaurent Bartholin
Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville VA 22908, USA
Dev Biol 319:285-97. 2008..placenta, due to a decrease in the fetal blood vessels, and decreased expression of the gap junction protein Gjb2 (Cx26)...
- Decreased oocyte-granulosa cell gap junction communication and connexin expression in a type 1 diabetic mouse modelAnn M Ratchford
Department of Obstetrics and Gynecology, Washington University in St Louis, St Louis, Missouri 63110, USA
Mol Endocrinol 22:2643-54. 2008..Real-time RT-PCR analyses confirmed the presence of Cx26, Cx37, and Cx57 mRNA and revealed a significant decrease in Cx37 mRNA expression in oocytes from diabetic mice ..
- Ablation of connexin30 in transgenic mice alters expression patterns of connexin26 and connexin32 in glial cells and leptomeningesB D Lynn
Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Eur J Neurosci 34:1783-93. 2011Expression of connexin26 (Cx26), Cx30 and Cx43 in astrocytes and expression of Cx29, Cx32 and Cx47 in oligodendrocytes of adult rodent brain has been well documented, as has the interdependence of connexin expression patterns of ..
- The liver connexin32 interactome is a novel plasma membrane-mitochondrial signaling nexusStephanie L Fowler
Neural Regeneration Laboratory, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada
J Proteome Res 12:2597-610. 2013..Complex formation increases the pool of sideroflexin-1 that is present at the plasma membrane. Together, these data identify a novel plasma membrane/mitochondrial signaling nexus in the connexin32 interactome...
- Ultrastructural pathological changes in the cochlear cells of connexin 26 conditional knockout miceLan Lin
Department of Pathology, Eye and ENT Hospital of Fudan University, Shanghai 200031, P R China
Mol Med Rep 8:1029-36. 2013Mutations in the gene of connexin 26 (Cx26) are the most common cause of human non‑syndromic hereditary deafness. The pathogenesis of deafness caused by Cx26 remains uncertain...
- Dominant negative connexin26 mutation R75W causing severe hearing loss influences normal programmed cell death in postnatal organ of CortiAyako Inoshita
Department of Otorhinolaryngology, Juntendo University Faculty of Medicine, Hongo 2 1 1, Bunkyo ku, Tokyo 113 8431, Japan
BMC Genet 15:1. 2014..mice that carry the R75W + mutation, a dominant-negative mutation of human gap junction protein, beta 2, 26 kDa (GJB2) (also known as connexin 26 or CX26). Cx26 facilitate intercellular communication within the mammalian auditory organ.
- Connexin26 (GJB2) deficiency reduces active cochlear amplification leading to late-onset hearing lossY Zhu
Dept of Otolaryngology, University of Kentucky Medical School, Lexington, KY 40536, United States
Neuroscience 284:719-29. 2015Connexin26 (Cx26, GJB2) mutations account for >50% of nonsyndromic hearing loss. The deafness is not always congenital. A large group of these patients (∼30%) demonstrate a late-onset hearing loss, starting in childhood...
- Pannexin1 channels dominate ATP release in the cochlea ensuring endocochlear potential and auditory receptor potential generation and hearingJin Chen
1 Department of Otolaryngology, University of Kentucky Medical Center, 800 Rose Street, Lexington, Kentucky, 40536, USA 2 Department of Otolaryngology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, P R of China
Sci Rep 5:10762. 2015..Moreover, defect of connexin hemichannels by deletion of connexin26 (Cx26) and Cx30, which are predominant connexin isoforms in the cochlea, did not reduce ATP release under physiological ..
- Mir-27a promotes apoptosis of cochlear sensory epithelium in Cx26 knockout miceYunfeng Wang
Department of Otolaryngology, Affiliated Eye and ENT Hospital of Fudan University, Building 9 Room 611, 83 Fenyang Road, Xuhui District, Shanghai 200031, China
Front Biosci (Landmark Ed) 21:364-73. 2016To investigate the underlying molecular mechanism for connexin 26 (Cx26) knockout-induced apoptosis, we performed TUNEL assays to detect apoptosis in the cochlear sensory epithelium in Cx26 knockout mice...
- Hepatocyte Growth Factor-c-MET Signaling Mediates the Development of Nonsensory Structures of the Mammalian Cochlea and HearingShumei Shibata
Tina and Rick Caruso Department of Otolaryngology Head and Neck Surgery, Zilkha Neurogenetic Institute, and
J Neurosci 36:8200-9. 2016..These results suggest a novel connection between HGF signaling and deafness via melanocyte deficiencies...
- Characterization of connexin31.1-deficient mice reveals impaired placental developmentQingyi Zheng-Fischhöfer
Institut fur Genetik, Abteilung Molekulargenetik, Universitat Bonn, D 53117 Bonn, Germany
Dev Biol 312:258-71. 2007..We conclude that Connexin31.1 is critical for normal placental development but appears to be functionally compensated by other connexin isoforms in the embryo proper and adult mouse...
- Milk secretion and ejection are impaired in the mammary gland of mice harboring a Cx43 mutant while expression and localization of tight and adherens junction proteins remain unchangedIsabelle Plante
Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada
Biol Reprod 82:837-47. 2010..Surprisingly, the levels and/or localization of Cx26 (Gjb2), Cx30 (Gjb6), Cx32 (Gjb1), E-cadherin, P-cadherin, beta-catenin, claudin-1, and occludin were all unaffected by ..
- The Cx26-G45E mutation displays increased hemichannel activity in a mouse model of the lethal form of keratitis-ichthyosis-deafness syndromeGulistan Mese
Department of Physiology and Biophysics, Stony Brook University, Stony Brook, NY 11794, USA
Mol Biol Cell 22:4776-86. 2011Mutations in the GJB2 gene (Cx26) cause deafness in humans. Most are loss-of-function mutations and cause nonsyndromic deafness...
- Role of p63 and the Notch pathway in cochlea development and sensorineural deafnessAlessandro Terrinoni
Biochemistry Laboratory Istituto Dermopatico Dell Immacolata, c o Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, 00133 Rome, Italy
Proc Natl Acad Sci U S A 110:7300-5. 2013....
- Laminin α1 is essential for mouse cerebellar developmentNaoki Ichikawa-Tomikawa
Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine, Tokyo, Japan
Matrix Biol 31:17-28. 2012..A marked reduction in numbers of dendritic processes in Purkinje cells was observed in Lama1(CKO) mice. Together, these results indicate that Lama1 is required for cerebellar development and functions...
- Maternal imprinting of the mouse Snrpn gene and conserved linkage homology with the human Prader-Willi syndrome regionS E Leff
Department of Pharmacology, Stanford University School of Medicine, California 94305
Nat Genet 2:259-64. 1992....
- Chromosomal assignments of mouse connexin genes, coding for gap junctional proteins, by somatic cell hybridizationH J Schwarz
Institut fur Genetik, Abt Molekulargenetik, Universitat Bonn, Germany
Somat Cell Mol Genet 18:351-9. 1992..In addition, our results confirm the recent assignment of mouse connexin genes Cx26, Cx32, Cx37, Cx40, Cx43, and Cx46 to mouse chromosomes 14, X, 4, 3, 10, and 14, respectively, by analysis of ..
- Connexin expression and gap junction communication compartments in the developing mouse limbD W Laird
Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada
Dev Dyn 195:153-61. 1992..Thus, the lack of dye transfer between the ectoderm and underlying mesenchyme from the peak of AER height through its decline suggests that bulk transfer of morphogens between these two layers is not necessary for mouse limb development...
- Zygotic expression of the connexin43 gene supplies subunits for gap junction assembly during mouse preimplantation developmentG Valdimarsson
Department of Zoology, University of Western Ontario, London, Canada
Mol Reprod Dev 30:18-26. 1991..We conclude that connexin43 is one member of the connexin gene family whose zygotic expression is critical for preimplantation morphogenesis...
- Distribution of genes for gap junction membrane channel proteins on human and mouse chromosomesC L Hsieh
Howard Hughes Medical Institute, Stanford, California
Somat Cell Mol Genet 17:191-200. 1991..1-q24.1; GJB1 (connexin32) to Xcen-q22; GJB2 (connexin26) to 13; and GJA3 (connexin46) also to 13, probably near GJB2...
- Developmental regulation of gap junction gene expression during mouse embryonic developmentM Nishi
Department of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, California 92037
Dev Biol 146:117-30. 1991..4) In an ES cell culture line, alpha 1 was the only gap junction gene product detected. This is consistent with the findings of alpha 1 expression in the embryonic inner cell mass region and in undifferentiated teratocarcinoma cells...
- Nonoverlapping expression of Cx43 and Cx26 in the mouse placenta and decidua: a pattern of gap junction gene expression differing from that in the ratC M Pauken
Department of Biology, University of Pennsylvania, Philadelphia 19104 6017, USA
Mol Reprod Dev 41:195-203. 1995We characterized the expression of two gap junction genes (Cx26 and Cx43) in the mouse decidua and placenta. In the decidua, in situ hybridization analysis and immunostaining studies revealed a high level of Cx43 expression...
- Analysis of multiple gap junction gene products in the rodent and human mammary glandA Pozzi
Department of Cell Biology, Scripps Research Institute, La Jolla, California 92037, USA
Exp Cell Res 220:212-9. 1995The expression and localization of three different connexins (alpha 1, Cx43; beta 1, Cx32; and beta 2, Cx26) were analyzed in human, mouse, and rat mammary glands by PCR analysis of reverse-transcribed RNA (RT-PCR) and indirect ..
- Expression of gap junction proteins connexin 26 and 43 is modulated during differentiation of keratinocytes in newborn mouse epidermisY Kamibayashi
Department of Dermatology, Sapporo Medical University School of Medicine, Japan
J Invest Dermatol 101:773-8. 1993We examined the expression of the gap junction proteins connexin 26 (Cx26), 32 (Cx32), and 43 (Cx43) in keratinocytes of newborn mouse epidermis to elucidate which connexins are expressed in keratinocytes in intact skin of newborn mice, ..
- Molecular cloning, chromosomal location, and tissue-specific expression of the murine cathepsin G geneJ W Heusel
Department of Medicine, Jewish Hospital at Washington University Medical Center, St Louis, MO 63110
Blood 81:1614-23. 1993..Expression of this gene is detected only in the bone marrow and is restricted to a small population of early myeloid cells. These findings are consistent with the identification of the gene encoding murine CG...
- Assignment of connexin 26 (GJB2) and 46 (GJA3) genes to human chromosome 13q11-->q12 and mouse chromosome 14D1-E1 by in situ hybridizationC Mignon
INSERM U 406, Faculté de la Timone, Marseille
Cytogenet Cell Genet 72:185-6. 1996
- Loss of alpha 1 connexin does not alter the prenatal differentiation of pancreatic beta cells and leads to the identification of another islet cell connexinA Charollais
Department of Morphology, University of Geneva, Medical School, Centre Medical Universitaire, Switzerland
Dev Genet 24:13-26. 1999..They further provide evidence that normal and tumoral insulin-producing cells natively coexpress connexins alpha 1 and alpha 6...
- Role of connexin (gap junction) genes in cell growth control and carcinogenesisH Yamasaki
Unit of Multistage Carcinogenesis, International Agency for Research on Cancer, Lyon, France
C R Acad Sci III 322:151-9. 1999..We have produced various dominant-negative mutants of Cx26, Cx32 and Cx43 and showed that some of them prevent the growth control exerted by the corresponding wild-type genes...
- Immunolocalization of connexin 26 in the developing mouse cochleaC M Frenz
Department of Otolaryngology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Brain Res Brain Res Rev 32:172-80. 2000..In this study, we demonstrate the temporal-spatial distribution of connexin 26 in the embryonic and early postnatal mouse cochlea...
- Acute-phase response and circadian expression of connexin26 are not altered in connexin32-deficient mouse liverA Temme
Abteilung Molekulargenetik, Institut fur Genetik, Universitat Bonn, Germany
Cell Tissue Res 300:111-7. 2000In mouse hepatocytes, the gap junctional proteins connexin32 (Cx32) and connexin26 (Cx26) are expressed in the same gap junctional plaque. Expression of the major Cx32 protein is downregulated during liver regeneration and cholestasis...
- The mouse gap junction gene connexin29 is highly expressed in sciatic nerve and regulated during brain developmentG Sohl
Institut fur Genetik, Abteilung Molekulargenetik, Universitat Bonn, Germany
Biol Chem 382:973-8. 2001..Our expression data suggest that the new connexin gene is active in myelin-forming glial cells...
- A gene-driven approach to the identification of ENU mutants in the mouseEmma L Coghill
MRC Mammalian Genetics Unit and UK Mouse Genome Centre, Harwell OX11 ORD, UK
Nat Genet 30:255-6. 2002..We provide support for this approach and report the identification of mutations in the gene (Gjb2) encoding connexin 26, using archives established from the UK ENU mutagenesis program.
- Mouse horizontal cells do not express connexin26 or connexin36M R Deans
Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
Cell Commun Adhes 8:361-6. 2001..Microscopy was used to further examine the distribution of Cx26 and Cx36...
- Apoptosis in uterine epithelium and decidua in response to implantation: evidence for two different pathwaysAnike Joswig
Institute of Anatomy, University Hospital of Essen, Essen, Germany
Reprod Biol Endocrinol 1:44. 2003....
- Connexins 26 and 30 are co-assembled to form gap junctions in the cochlea of miceShoab Ahmad
Section on Neurobiology, Leslie and Susan Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA 90057 1922, USA
Biochem Biophys Res Commun 307:362-8. 2003..Two of these connexins (Cx26 and Cx30), both belonging to the beta-group, were investigated for their molecular assemblies in the cochlea...
- An update on connexin genes and their nomenclature in mouse and manGoran Sohl
Institut fur Genetik, Universitat Bonn, Germany
Cell Commun Adhes 10:173-80. 2003..Furthermore, this short review contains an update on phenotypic correlations between connexin deficient mice and patients bearing mutations in their orthologous connexin genes...
- A reporter allele for investigating connexin 26 gene expression in the mouse brainMikhail A Filippov
Department of Clinical Neurobiology, University Hospital of Neurology, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany
Eur J Neurosci 18:3183-92. 2003..In order to define the cellular distribution of connexin 26 (Cx26) in the mouse we have generated a reporter allele (Cx26lacZ) by genetically manipulating the locus so ..
- mRNA expression pattern of multiple members of connexin gene family in normal and abnormal fetal gonads in mouseSubhash C Juneja
Department of Zoology, The University of Western Ontario, London, Canada
Indian J Physiol Pharmacol 47:147-56. 2003..5 dpc knockout (Cx43-/-) fetuses. The mRNA expression pattern of connexins (Cx26, Cx30.3, Cx31, Cx31.1, Cx32, Cx37, Cx40, Cx43, Cx45, Cx46 and Cx50) was analyzed by RT-PCR...
- The novel mouse connexin39 gene is expressed in developing striated muscle fibersJulia von Maltzahn
Institut fur Genetik, Abteilung Molekulargenetik, Universitat Bonn, Römerstr 164, 53117 Bonn, Germany
J Cell Sci 117:5381-92. 2004..As expression of no other known connexin could be verified in these cells, intercellular dye transfer might result from functional expression of Cx39 in developing striated muscle fibers...
- Cx31 and Cx43 double-deficient mice reveal independent functions in murine placental and skin developmentMark Kibschull
Institute of Anatomy, University Hospital Duisburg Essen, Essen, Germany
Dev Dyn 233:853-63. 2005..Therefore, in epidermal and preimplantation development, gap junctional communication can probably be compensated by other isoforms coexpressed with Cx31 and Cx43...
- Ablation of gap junctional communication in hepatocytes of transgenic mice does not lead to disrupted cellular homeostasis or increased spontaneous tumourigenesisThomas Ott
Institut fur Genetik, Abteilung Molekulargenetik, Universitat Bonn, Römerstr 164, D 53117 Bonn, Germany
Eur J Cell Biol 85:717-28. 2006Gap junctions between murine hepatocytes are composed of two subunit proteins, connexin26 (Cx26) and connexin32 (Cx32)...
- Modulation of connexin expression and gap junction communication in astrocytes by the gram-positive bacterium S. aureusNilufer Esen
Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Glia 55:104-17. 2007..Here we investigated the effects of S. aureus and its cell wall product peptidoglycan (PGN) on Cx43, Cx30, and Cx26 expression, the main Cx isoforms found in astrocytes...
- Restoration of connexin26 protein level in the cochlea completely rescues hearing in a mouse model of human connexin30-linked deafnessShoeb Ahmad
Department of Otolaryngology, Yerkes Microarray Core, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322 3030, USA
Proc Natl Acad Sci U S A 104:1337-41. 2007Mutations in genes coding for connexin26 (Cx26) and/or Cx30 are linked to approximately half of all cases of human autosomal nonsyndromic prelingual deafness...
- Connexin levels regulate keratinocyte differentiation in the epidermisStephanie Langlois
Department of Anatomy and Cell Biology, The University of Western Ontario, London, Ontario, N6A 5C1, Canada
J Biol Chem 282:30171-80. 2007..When Cx43 expression was knocked down by 50-75%, there was a coordinate 55-65% reduction in Cx26 level, gap junction-based dye coupling was reduced by 60%, and transepithelial resistance decreased...
- Analysis of connexin subunits required for the survival of vestibular hair cellsYan Qu
Department of Otolaryngology, Emory University School of Medicine, Atlanta, Georgia 30322 3030, USA
J Comp Neurol 504:499-507. 2007..The most commonly found human Cx mutations are either Cx26 or Cx30 deletions...
- Cooperative function of Tbx1 and Brn4 in the periotic mesenchyme is necessary for cochlea formationEvan M Braunstein
Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
J Assoc Res Otolaryngol 9:33-43. 2008....
- Tumor promotion in liver of mice with a conditional Cx26 knockoutPhilip Marx-Stoelting
Institute of Pharmacology and Toxicology, Department of Toxicology, University of Tubingen, Wilhelmstr 56, 72074 Tubingen, Germany
Toxicol Sci 103:260-7. 2008..To investigate whether Cx26 plays a similar role, an initiation-promotion experiment was conducted using mice with a liver-specific knockout of ..
- Pancreatic inactivation of c-Myc decreases acinar mass and transdifferentiates acinar cells into adipocytes in miceClaire Bonal
Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland
Gastroenterology 136:309-319.e9. 2009..The basic helix-loop-helix transcription factor c-Myc is one of the main regulators of these processes in many organs. We studied the requirement of c-Myc in controlling the generation and maintenance of pancreatic mass...
- Syncytin-A knockout mice demonstrate the critical role in placentation of a fusogenic, endogenous retrovirus-derived, envelope geneAnne Dupressoir
Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, Unité Mixte de Recherche 8122, Centre National de Recherche Scientifique, Institut Gustave Roussy, 94805 Villejuif, and Université Paris Sud, 91405 Orsay, France
Proc Natl Acad Sci U S A 106:12127-32. 2009....
- Expression of Pou3f3/Brn-1 and its genomic methylation in developing auditory epitheliumHideki Mutai
Laboratory of Auditory Disorders, National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo, Japan
Dev Neurobiol 69:913-30. 2009..This is the first report to study involvement of an epigenetic regulatory mechanism in the developing mammalian auditory epithelium...
- Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexinsFrancisco J del Castillo
Unite de Genetique et Physiologie de l Audition, Institut Pasteur, Paris, France
Hum Mol Genet 19:262-75. 2010..Sequence accession numbers. GenBank: Human CNST cDNA, NM_152609; mouse Cnst cDNA, NM_146105...
- Asparagine 175 of connexin32 is a critical residue for docking and forming functional heterotypic gap junction channels with connexin26So Nakagawa
Institute for Protein Research, Osaka University, Suita, Osaka, Japan
J Biol Chem 286:19672-81. 2011..Based on the crystal structure of the Cx26 gap junction channel and homology models of heterotypic channels, we analyzed docking selectivity for several ..
- Mammalian Llgl2 is necessary for proper branching morphogenesis during placental developmentSmitha Sripathy
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Mol Cell Biol 31:2920-33. 2011....
- Connexin26 expression in brain parenchymal cells demonstrated by targeted connexin ablation in transgenic miceJ I Nagy
Department of Physiology, Faculty of Medicine, University of Manitoba, 745 Bannatyne Ave, Winnipeg, MB, Canada R3E 0J9
Eur J Neurosci 34:263-71. 2011..Cx30) and connexin43 (Cx43), but it has remained controversial whether these cells also express connexin26 (Cx26). To investigate this issue further, we examined immunofluorescence labelling of glial connexins in wild-type vs...
- Focal adhesion kinase modulates radial glia-dependent neuronal migration through connexin-26Manuel Valiente
Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
J Neurosci 31:11678-91. 2011..These results indicate that FAK plays a fundamental role in the dynamic regulation of Gap-mediated adhesions during glial-guided neuronal migration in the mouse...
- Impaired stria vascularis integrity upon loss of E-cadherin in basal cellsMark Oliver Trowe
Institut fur Molekularbiologie, OE5250, Medizinische Hochschule Hannover, Carl Neuberg Str 1, D 30625 Hannover, Germany
Dev Biol 359:95-107. 2011....
- The hepatocyte-specific phenotype of murine liver cells correlates with high expression of connexin32 and connexin26 but very low expression of connexin43R Stutenkemper
Institute für Genetik, Abteilung Molekulargenetik, Universitat Bonn, Germany
Exp Cell Res 201:43-54. 1992..Furthermore several dedifferentiated cell lines derived from rat or mouse liver and cultivated in serum-containing medium were found to express little connexin32 or connexin26 mRNA but relatively high levels of connexin43 mRNA...
- Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mappingJ A Haefliger
Department of Anatomy and Cellular Biology, Harvard Medical School, Boston, Massachusetts 02115
J Biol Chem 267:2057-64. 1992..Cx40, Cx37, and Cx33 are similar to the previously characterized Cx43 and Cx46. Cx31.1 is similar to Cx26, Cx31, and Cx32...
- Rapid modulation of gap junction expression in mouse mammary gland during pregnancy, lactation, and involutionP Monaghan
Institute of Cancer Research, Haddow Laboratories, Sutton, Surrey, United Kingdom
J Histochem Cytochem 42:931-8. 1994....
- Multiple members of the connexin gene family participate in preimplantation development of the mouseT C Davies
Department of Zoology, University of Western Ontario, London, Canada
Dev Genet 18:234-43. 1996..The expression of multiple connexin genes during this early period of embryogenesis (when there are only two distinct cell types) raises questions about the functional significance of connexin diversity in this context...
- Expression of the gap junction proteins connexin31 and connexin43 correlates with communication compartments in extraembryonic tissues and in the gastrulating mouse embryo, respectivelyE Dahl
Abt Molekulargenetik, Universitat Bonn, Germany
J Cell Sci 109:191-7. 1996..The communication boundary between those compartments may be due to incompatibility of connexin31 and connexin43 hemichannels, which do not communicate with each other in cell culture...
- Isolation and characterization of a bovine neural specific protein (CRMP-2) cDNA homologous to unc-33, a C. elegans gene implicated in axonal outgrowth and guidanceT Kamata
SAIC Frederick, IRSP, National Cancer Institute NCI FCRDC, Frederick, MD 21702, USA
Brain Res Mol Brain Res 54:219-36. 1998..Taken together, these data suggest multi-functional roles for CRMP-2 in developing and adult nervous systems, and the biological activity of CRMP-2 could be regulated by phosphorylation reaction...
- Gap junctions in normal and neoplastic mammary glandD Locke
Institute of Cancer Research, Sutton, Surrey, U K
J Pathol 186:343-9. 1998....
- TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair folliclesT Kojima
Department of Hematopoietic Factors, The Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo 108 8639, Japan
J Biol Chem 275:20742-7. 2000..The Troy gene is located near the waved coat (Wc) locus, a mutant related to abnormalities in skin and hair...
- Exocrine specific expression of Connexin32 is dependent on the basic helix-loop-helix transcription factor Mist1J Michael Rukstalis
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907 1392, USA
J Cell Sci 116:3315-25. 2003..In pancreatic acini, the connexin26 (Cx26) and connexin32 (Cx32) proteins form functional channels that coordinate the secretion of digestive enzymes...
- An expression atlas of connexin genes in the mouseAnnalisa Buniello
Telethon Institute of Genetics and Medicine, Via P Castellino 111, 80131 Naples, Italy
Genomics 83:812-20. 2004....
- Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform responseAli R Djalilian
National Human Genome Research Institute, National Eye Institute, and National Institute of Child Health and Development, NIH, Bethesda, Maryland 20892, USA
J Clin Invest 116:1243-53. 2006..gene expression to involved psoriatic plaques, including a significant upregulation of the gap junction protein connexin 26 (Cx26)...
- Oleamide derivatives suppress the spontaneous metastasis by inhibiting connexin 26Yusuke Ohba
Department of Synthetic Organic Chemistry, Graduate School of Pharmaceutical Science, Osaka University, Osaka, Japan
Int J Cancer 121:47-54. 2007We previously reported that overexpressing connexin 26 (Cx26) enhances the spontaneous metastasis of mouse BL6 melanoma cells...
- Identification of connexin36 in gap junctions between neurons in rodent locus coeruleusJ E Rash
Department of Biomedical Sciences, Colorado State University, Campus Delivery 1617, Fort Collins, CO 80523, USA
Neuroscience 147:938-56. 2007..these neurons are linked by extraordinarily abundant gap junctions consisting of connexin32 (Cx32) and connexin26 (Cx26), and that those same connexins abundantly link neurons to astrocytes...
- Expression of connexins in embryonic mouse neocortical developmentCima Cina
Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
J Comp Neurol 504:298-313. 2007..reaction, Western blot analysis, and immunohistochemistry, we found that among the family of gap junction proteins, Cx26, Cx36, Cx37, Cx43, and Cx45 were expressed in the developing cortex of mice, Cx30 and Cx32 were absent, while Cx40 ..
- Chromosomal localization of the mammalian peptide-methionine sulfoxide reductase gene and its differential expression in various tissuesJ Moskovitz
Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ 07110 1199, USA
Proc Natl Acad Sci U S A 93:3205-8. 1996..In addition, blood and alveolar macrophages showed high expression of the enzyme. The msrA gene was mapped to the central region of mouse chromosome 14, in a region of homology with human chromosomes 13 and 8p21...
- Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/wartsN Yabuta
Department of Molecular Genetics, Department of Science for Laboratory Animal Experimentation, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita, Osaka, 565 0871, Japan
Genomics 63:263-70. 2000....
- Strain background effects and genetic modifiers of hearing in miceKenneth R Johnson
The Jackson Laboratory, Bar Harbor, ME 04609, USA
Brain Res 1091:79-88. 2006..Because modifier genes and digenic inheritance are not always distinguishable, we also include in this review several examples of digenic inheritance of hearing loss that have been reported in both mice and humans...
- Zeiss LSM 510 Laser Scanning MicroscopeJOHN RASH; Fiscal Year: 2002..The DIC Board of Directors will meet bi-monthly to insure continued efficient scheduling and operation of the replacement confocal microscope, to consider future upgrades, and to establish or change DIC access policies. ..
- Gap Junctions and Connexins in Developing CNSJOHN RASH; Fiscal Year: 2005....
- Connexins in Neuronal and Glial Gap Junctions in the Central Nervous SystemJOHN RASH; Fiscal Year: 2007..abstract_text> ..