Gjb2

Summary

Gene Symbol: Gjb2
Description: gap junction protein, beta 2
Alias: AI325222, Cnx26, Cx26, Gjb-2, gap junction beta-2 protein, connexin-26, gap junction membrane channel protein beta 2
Species: mouse

Top Publications

  1. ncbi Expression of connexins in the developing olfactory system of the mouse
    F Miragall
    Institut fur Anatomie, Universitat Regensburg, Germany
    J Comp Neurol 325:359-78. 1992
  2. ncbi Differential expression of gap junction mRNAs and proteins in the developing murine kidney and in experimentally induced nephric mesenchymes
    K Sainio
    Department of Pathology, University of Helsinki, Finland
    Development 115:827-37. 1992
  3. ncbi Aberrant expression of gap junction proteins (connexins) is associated with tumor progression during multistage mouse skin carcinogenesis in vivo
    Y Kamibayashi
    Department of Pathology, Sapporo Medical University School of Medicine, Japan
    Carcinogenesis 16:1287-97. 1995
  4. ncbi Connexin expression and gap junctions in the mammary gland
    P Monaghan
    Institute of Cancer Research, Haddow Laboratories, Sutton, Surrey, U K
    Cell Biol Int 20:121-5. 1996
  5. ncbi Connexin 26 mutations in hereditary non-syndromic sensorineural deafness
    D P Kelsell
    Academic Department of Dermatology, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, UK
    Nature 387:80-3. 1997
  6. ncbi Expression pattern of different gap junction connexins is related to embryo implantation
    R Grummer
    Institute of Anatomy, University of Essen, Germany
    Int J Dev Biol 40:361-7. 1996
  7. pmc Transplacental uptake of glucose is decreased in embryonic lethal connexin26-deficient mice
    H D Gabriel
    Institut fur Genetik, Abt Molekulargenetik, Universitat Bonn, 53117 Bonn, Germany
    J Cell Biol 140:1453-61. 1998
  8. ncbi Diverse functions of vertebrate gap junctions
    A M Simon
    Dept of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Trends Cell Biol 8:477-83. 1998
  9. ncbi Genetic diseases and gene knockouts reveal diverse connexin functions
    T W White
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Physiol 61:283-310. 1999
  10. pmc Targeted ablation of connexin26 in the inner ear epithelial gap junction network causes hearing impairment and cell death
    Martine Cohen-Salmon
    Unité de Génétique des Déficits Sensoriels, CNRS URA 1968, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Curr Biol 12:1106-11. 2002

Scientific Experts

  • Anne Dupressoir
  • Alessandro Terrinoni
  • George Bakirtzis
  • K R Johnson
  • H Yamasaki
  • D Locke
  • Kazusaku Kamiya
  • T W White
  • Subhash C Juneja
  • A Forge
  • J I Nagy
  • D P Kelsell
  • JOHN RASH
  • Anike Joswig
  • Klaus Willecke
  • Yunfeng Wang
  • Xi Lin
  • Wenxue Tang
  • Giulia Crispino
  • Thomas Ott
  • Goran Sohl
  • Chun Liang
  • K Willecke
  • Yu Sun
  • Fabio Mammano
  • A Minekawa
  • Qing Chang
  • A Inoshita
  • Saida Ortolano
  • Fabio Anselmi
  • Elke Winterhager
  • Shumei Shibata
  • Yan Qu
  • Y Zhu
  • Jin Chen
  • Ping Chen
  • Ayako Inoshita
  • Mark Kibschull
  • Yan Zhu
  • Hong Bo Zhao
  • Lan Lin
  • Stephanie L Fowler
  • Huawei Li
  • Martine Cohen-Salmon
  • Naoki Ichikawa-Tomikawa
  • Mikhail A Filippov
  • Smitha Sripathy
  • Melanie Schütz
  • Gulistan Mese
  • Mark Oliver Trowe
  • So Nakagawa
  • Nikolai Dicke
  • B D Lynn
  • Manuel Valiente
  • Shoab Ahmad
  • N A Jenkins
  • N G Copeland
  • Francisco J del Castillo
  • Isabelle Plante
  • John A Chiorini
  • Giovanni Di Pasquale
  • Claire Bonal
  • Hideki Mutai
  • H O Okamura
  • T Iizuka
  • Qing Shao
  • Dale W Laird
  • K Ikeda
  • Laurent Bartholin
  • Ann M Ratchford
  • Philip Marx-Stoelting
  • Evan M Braunstein
  • Michael Schwarz
  • Shoeb Ahmad
  • Yusuke Ohba
  • Nilufer Esen
  • Stephanie Langlois
  • Cima Cina
  • Qingyi Zheng-Fischhöfer
  • Ali R Djalilian
  • Christine Petit
  • O Traub
  • D J Gilbert
  • Hannah Monyer
  • Yanping Zhang
  • A Temme
  • Celine Bry
  • Annalisa Buniello
  • Julia von Maltzahn
  • Xiaodong Gu

Detail Information

Publications101 found, 100 shown here

  1. ncbi Expression of connexins in the developing olfactory system of the mouse
    F Miragall
    Institut fur Anatomie, Universitat Regensburg, Germany
    J Comp Neurol 325:359-78. 1992
    ..Moreover, our findings indicate that although expression of connexin43 in the olfactory system is developmentally regulated, it is not directly associated with the neuronal cell turnover of the olfactory epithelium...
  2. ncbi Differential expression of gap junction mRNAs and proteins in the developing murine kidney and in experimentally induced nephric mesenchymes
    K Sainio
    Department of Pathology, University of Helsinki, Finland
    Development 115:827-37. 1992
    The expression of three gap junction (GJ) proteins, alpha 1 (Cx43), beta 1 (Cx32), and beta 2 (Cx26), and their transcripts were examined during the ontogeny of the mouse and rat kidney...
  3. ncbi Aberrant expression of gap junction proteins (connexins) is associated with tumor progression during multistage mouse skin carcinogenesis in vivo
    Y Kamibayashi
    Department of Pathology, Sapporo Medical University School of Medicine, Japan
    Carcinogenesis 16:1287-97. 1995
    ..mouse skin carcinogenesis in vivo, we immunohistochemically and morphometrically analyzed the expression of connexin 26 (Cx26) and connexin 43 (Cx43) in papillomas, well-, moderately- and poorly-differentiated squamous cell ..
  4. ncbi Connexin expression and gap junctions in the mammary gland
    P Monaghan
    Institute of Cancer Research, Haddow Laboratories, Sutton, Surrey, U K
    Cell Biol Int 20:121-5. 1996
    ..Analysis of connexin expression at the molecular level is now bringing new insights into the structure and function of gap junctions in a range of normal and pathological cell systems...
  5. ncbi Connexin 26 mutations in hereditary non-syndromic sensorineural deafness
    D P Kelsell
    Academic Department of Dermatology, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, UK
    Nature 387:80-3. 1997
    ..of autosomal dominant deafness and have identified a mutation in the gene encoding the gap-junction protein connexin 26 (Cx26) that segregates with the profound deafness in the family...
  6. ncbi Expression pattern of different gap junction connexins is related to embryo implantation
    R Grummer
    Institute of Anatomy, University of Essen, Germany
    Int J Dev Biol 40:361-7. 1996
    ..b>cx26 is locally expressed in the uterine epithelium of the implantation chamber, cx43 in the surrounding decidua prior ..
  7. pmc Transplacental uptake of glucose is decreased in embryonic lethal connexin26-deficient mice
    H D Gabriel
    Institut fur Genetik, Abt Molekulargenetik, Universitat Bonn, 53117 Bonn, Germany
    J Cell Biol 140:1453-61. 1998
    ....
  8. ncbi Diverse functions of vertebrate gap junctions
    A M Simon
    Dept of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Trends Cell Biol 8:477-83. 1998
    ....
  9. ncbi Genetic diseases and gene knockouts reveal diverse connexin functions
    T W White
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Physiol 61:283-310. 1999
    ..In addition, gene targeting of connexins in mice has provided new insights into connexin function and the significance of connexin diversity...
  10. pmc Targeted ablation of connexin26 in the inner ear epithelial gap junction network causes hearing impairment and cell death
    Martine Cohen-Salmon
    Unité de Génétique des Déficits Sensoriels, CNRS URA 1968, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Curr Biol 12:1106-11. 2002
    Mutations in the gene encoding the gap junction protein connexin26 (Cx26) are responsible for the autosomal recessive isolated deafness, DFNB1, which accounts for half of the cases of prelingual profound hereditary deafness in Caucasian ..
  11. ncbi Gap junctions in the inner ear: comparison of distribution patterns in different vertebrates and assessement of connexin composition in mammals
    Andrew Forge
    UCL Centre for Auditory Research and Institute of Laryngology and Otology, University College London, London WC1X 8EE, United Kingdom
    J Comp Neurol 467:207-31. 2003
    ..in the mammalian inner ear by RT-PCR, Western blotting, and immunohistochemistry revealed four connexin isotypes, cx26, cx30, cx31, and cx43, in the cochlea and three, cx26, cx30, and cx43, in the vestibular organs...
  12. ncbi Loss of connexin 26 in mammary epithelium during early but not during late pregnancy results in unscheduled apoptosis and impaired development
    Celine Bry
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Dev Biol 267:418-29. 2004
    ..Gap junctions are intercellular channels that are formed by the protein family of connexins (Cxs). In mammary tissue, Cx26 and Cx32 are present in the secretory epithelium and Cx43 is localized in the myoepithelium...
  13. ncbi Altered permeability and modulatory character of connexin channels during mammary gland development
    Darren Locke
    Department of Pharmacology and Physiology, UMDNJ, Newark, NJ 07101, USA
    Exp Cell Res 298:643-60. 2004
    ..Microarray study shows that the principal connexin isoform in epithelial cells during pregnancy is Cx26, up-regulated and persisting from the virgin. After parturition, there is rapid induction of Cx32...
  14. pmc Gap junction-mediated intercellular biochemical coupling in cochlear supporting cells is required for normal cochlear functions
    Yanping Zhang
    Department of Otolaryngology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322 3030, USA
    Proc Natl Acad Sci U S A 102:15201-6. 2005
    Dysfunction of gap junctions (GJs) caused by mutations in connexin26 (Cx26) and Cx30 accounts for nearly half of all cases of hereditary nonsyndromic deafness cases...
  15. doi Postnatal development of the organ of Corti in dominant-negative Gjb2 transgenic mice
    A Inoshita
    Department of Otorhinolaryngology, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    Neuroscience 156:1039-47. 2008
    ..50%) of congenital bilateral nonsyndromic sensorineural deafness cases have been linked to mutations in the GJB2 coding for the connexin26...
  16. pmc ATP release through connexin hemichannels and gap junction transfer of second messengers propagate Ca2+ signals across the inner ear
    Fabio Anselmi
    Foundation for Advanced Biomedical Research, Venetian Institute of Molecular Medicine, 35129 Padua, Italy
    Proc Natl Acad Sci U S A 105:18770-5. 2008
    ..By contrast, Ca(2+) responses failed to propagate in cultures with defective expression of connexin 26 (Cx26) or Cx30...
  17. pmc Coordinated control of connexin 26 and connexin 30 at the regulatory and functional level in the inner ear
    Saida Ortolano
    Venetian Institute of Molecular Medicine, Foundation for Advanced Biomedical Research, 35129 Padua, Italy
    Proc Natl Acad Sci U S A 105:18776-81. 2008
    b>Connexin 26 (Cx26) and connexin 30 (Cx30) are encoded by two genes (GJB2 and GJB6, respectively) that are found within 50 kb in the same complex deafness locus, DFNB1...
  18. pmc Targeted connexin26 ablation arrests postnatal development of the organ of Corti
    Yunfeng Wang
    Department of Otolaryngology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322 3030, USA
    Biochem Biophys Res Commun 385:33-7. 2009
    Mutations in the gene coding for connexin26 (Cx26) is the most common cause of human nonsyndromic hereditary deafness...
  19. pmc Connexin30 null and conditional connexin26 null mice display distinct pattern and time course of cellular degeneration in the cochlea
    Yu Sun
    Department of Otolaryngology, Emory University School of Medicine, Atlanta, GA 30322 3030, USA
    J Comp Neurol 516:569-79. 2009
    Mutations in connexin26 (Cx26) and Cx30 are the most common cause of nonsyndromic inherited deafness in humans...
  20. doi Cochlear outer hair cells in a dominant-negative connexin26 mutant mouse preserve non-linear capacitance in spite of impaired distortion product otoacoustic emission
    A Minekawa
    Department of Otorhinolaryngology, Juntendo University School of Medicine, Tokyo, Japan
    Neuroscience 164:1312-9. 2009
    ..Transgenic mice were established carrying human Cx26 with the R75W mutation that was identified in a deaf family with autosomal dominant negative inheritance [Kudo T et ..
  21. doi The connexin26 S17F mouse mutant represents a model for the human hereditary keratitis-ichthyosis-deafness syndrome
    Melanie Schütz
    Institut for Genetik, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
    Hum Mol Genet 20:28-39. 2011
    Mutations in the GJB2 gene coding for connexin26 (Cx26) can cause a variety of deafness and hereditary hyperproliferative skin disorders in humans...
  22. doi Peripheral lymphangiogenesis in mice depends on ectodermal connexin-26 (Gjb2)
    Nikolai Dicke
    Institute of Genetics, Division of Molecular Genetics, University of Bonn, 53117 Bonn, Germany
    J Cell Sci 124:2806-15. 2011
    In order to study the specific function of connexin-26 (Cx26, also known as gap junction beta-2 protein; Gjb2), we generated knockin mice that expressed either a floxed lacZ reporter or, after Cre-mediated deletion, connexin-32 (Cx32)-..
  23. pmc BAAV mediated GJB2 gene transfer restores gap junction coupling in cochlear organotypic cultures from deaf Cx26Sox10Cre mice
    Giulia Crispino
    Fondazione per la Ricerca Biomedica Avanzata, Istituto Veneto di Medicina Molecolare, Padova, Italy
    PLoS ONE 6:e23279. 2011
    ..the expression and function of connexin26 and connexin30 from postnatal day 5 to adult age in double transgenic Cx26(Sox10Cre) mice, which we obtained by crossing connexin26 floxed mice with a deleter Sox10-Cre line...
  24. pmc Cell degeneration is not a primary causer for Connexin26 (GJB2) deficiency associated hearing loss
    Chun Liang
    Department of Otolaryngology, University of Kentucky Medical School, Lexington, KY 40536, USA
    Neurosci Lett 528:36-41. 2012
    Connexin26 (Cx26, GJB2) mutations can induce congenital deafness and are responsible for ∼50% of nonsyndromic hearing loss in children...
  25. ncbi Molecular cloning of mouse connexins26 and -32: similar genomic organization but distinct promoter sequences of two gap junction genes
    H Hennemann
    Institut für Genetik Abt Molekulargenetik, Universität Bonn Germany
    Eur J Cell Biol 58:81-9. 1992
    ..The first exon of each gene is preceded by a TATA-less promoter region. The promoter of the mouse Cx26 gene has at least two transcription start sites and is located in a very GC-rich region which is reminiscent of ..
  26. ncbi Differential expression of the gap junction proteins connexin45, -43, -40, -31, and -26 in mouse skin
    A Butterweck
    Abt Molekulargenetik der Universität, Bonn Germany
    Eur J Cell Biol 65:152-63. 1994
    ..In the epidermis of adult mice Cx43 and -31 were located similarly as in embryonic tissue, but Cx45 as well as Cx26 were not detected and in addition Cx40 was weakly expressed in the stratum basale...
  27. ncbi Changing patterns of gap junctional intercellular communication and connexin distribution in mouse epidermis and hair follicles during embryonic development
    R Choudhry
    Department of Dermatology, University of Glasgow, Scotland
    Dev Dyn 210:417-30. 1997
    ....
  28. ncbi The effects of a mutant connexin 26 on epidermal differentiation
    George Bakirtzis
    Division of Cancer Sciences and Molecular Pathology, University of Glasgow, Glasgow, Scotland, United Kingdom
    Cell Commun Adhes 10:359-64. 2003
    ..inherited skin diseases, transgenic mice were produced that express the true Vohwinkel syndrome-associated mutant Cx26 (D66H), from a keratin 10 promoter, specifically in the suprabasal epidermal keratinocytes...
  29. pmc Maternal Tgif is required for vascularization of the embryonic placenta
    Laurent Bartholin
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville VA 22908, USA
    Dev Biol 319:285-97. 2008
    ..placenta, due to a decrease in the fetal blood vessels, and decreased expression of the gap junction protein Gjb2 (Cx26)...
  30. pmc Decreased oocyte-granulosa cell gap junction communication and connexin expression in a type 1 diabetic mouse model
    Ann M Ratchford
    Department of Obstetrics and Gynecology, Washington University in St Louis, St Louis, Missouri 63110, USA
    Mol Endocrinol 22:2643-54. 2008
    ..Real-time RT-PCR analyses confirmed the presence of Cx26, Cx37, and Cx57 mRNA and revealed a significant decrease in Cx37 mRNA expression in oocytes from diabetic mice ..
  31. doi Ablation of connexin30 in transgenic mice alters expression patterns of connexin26 and connexin32 in glial cells and leptomeninges
    B D Lynn
    Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Eur J Neurosci 34:1783-93. 2011
    Expression of connexin26 (Cx26), Cx30 and Cx43 in astrocytes and expression of Cx29, Cx32 and Cx47 in oligodendrocytes of adult rodent brain has been well documented, as has the interdependence of connexin expression patterns of ..
  32. pmc The liver connexin32 interactome is a novel plasma membrane-mitochondrial signaling nexus
    Stephanie L Fowler
    Neural Regeneration Laboratory, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada
    J Proteome Res 12:2597-610. 2013
    ..Complex formation increases the pool of sideroflexin-1 that is present at the plasma membrane. Together, these data identify a novel plasma membrane/mitochondrial signaling nexus in the connexin32 interactome...
  33. pmc Ultrastructural pathological changes in the cochlear cells of connexin 26 conditional knockout mice
    Lan Lin
    Department of Pathology, Eye and ENT Hospital of Fudan University, Shanghai 200031, P R China
    Mol Med Rep 8:1029-36. 2013
    Mutations in the gene of connexin 26 (Cx26) are the most common cause of human non‑syndromic hereditary deafness. The pathogenesis of deafness caused by Cx26 remains uncertain...
  34. pmc Dominant negative connexin26 mutation R75W causing severe hearing loss influences normal programmed cell death in postnatal organ of Corti
    Ayako Inoshita
    Department of Otorhinolaryngology, Juntendo University Faculty of Medicine, Hongo 2 1 1, Bunkyo ku, Tokyo 113 8431, Japan
    BMC Genet 15:1. 2014
    ..mice that carry the R75W + mutation, a dominant-negative mutation of human gap junction protein, beta 2, 26 kDa (GJB2) (also known as connexin 26 or CX26). Cx26 facilitate intercellular communication within the mammalian auditory organ.
  35. pmc Connexin26 (GJB2) deficiency reduces active cochlear amplification leading to late-onset hearing loss
    Y Zhu
    Dept of Otolaryngology, University of Kentucky Medical School, Lexington, KY 40536, United States
    Neuroscience 284:719-29. 2015
    Connexin26 (Cx26, GJB2) mutations account for >50% of nonsyndromic hearing loss. The deafness is not always congenital. A large group of these patients (∼30%) demonstrate a late-onset hearing loss, starting in childhood...
  36. pmc Pannexin1 channels dominate ATP release in the cochlea ensuring endocochlear potential and auditory receptor potential generation and hearing
    Jin Chen
    1 Department of Otolaryngology, University of Kentucky Medical Center, 800 Rose Street, Lexington, Kentucky, 40536, USA 2 Department of Otolaryngology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, P R of China
    Sci Rep 5:10762. 2015
    ..Moreover, defect of connexin hemichannels by deletion of connexin26 (Cx26) and Cx30, which are predominant connexin isoforms in the cochlea, did not reduce ATP release under physiological ..
  37. ncbi Mir-27a promotes apoptosis of cochlear sensory epithelium in Cx26 knockout mice
    Yunfeng Wang
    Department of Otolaryngology, Affiliated Eye and ENT Hospital of Fudan University, Building 9 Room 611, 83 Fenyang Road, Xuhui District, Shanghai 200031, China
    Front Biosci (Landmark Ed) 21:364-73. 2016
    To investigate the underlying molecular mechanism for connexin 26 (Cx26) knockout-induced apoptosis, we performed TUNEL assays to detect apoptosis in the cochlear sensory epithelium in Cx26 knockout mice...
  38. pmc Hepatocyte Growth Factor-c-MET Signaling Mediates the Development of Nonsensory Structures of the Mammalian Cochlea and Hearing
    Shumei Shibata
    Tina and Rick Caruso Department of Otolaryngology Head and Neck Surgery, Zilkha Neurogenetic Institute, and
    J Neurosci 36:8200-9. 2016
    ..These results suggest a novel connection between HGF signaling and deafness via melanocyte deficiencies...
  39. ncbi Characterization of connexin31.1-deficient mice reveals impaired placental development
    Qingyi Zheng-Fischhöfer
    Institut fur Genetik, Abteilung Molekulargenetik, Universitat Bonn, D 53117 Bonn, Germany
    Dev Biol 312:258-71. 2007
    ..We conclude that Connexin31.1 is critical for normal placental development but appears to be functionally compensated by other connexin isoforms in the embryo proper and adult mouse...
  40. doi Milk secretion and ejection are impaired in the mammary gland of mice harboring a Cx43 mutant while expression and localization of tight and adherens junction proteins remain unchanged
    Isabelle Plante
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada
    Biol Reprod 82:837-47. 2010
    ..Surprisingly, the levels and/or localization of Cx26 (Gjb2), Cx30 (Gjb6), Cx32 (Gjb1), E-cadherin, P-cadherin, beta-catenin, claudin-1, and occludin were all unaffected by ..
  41. pmc The Cx26-G45E mutation displays increased hemichannel activity in a mouse model of the lethal form of keratitis-ichthyosis-deafness syndrome
    Gulistan Mese
    Department of Physiology and Biophysics, Stony Brook University, Stony Brook, NY 11794, USA
    Mol Biol Cell 22:4776-86. 2011
    Mutations in the GJB2 gene (Cx26) cause deafness in humans. Most are loss-of-function mutations and cause nonsyndromic deafness...
  42. pmc Role of p63 and the Notch pathway in cochlea development and sensorineural deafness
    Alessandro Terrinoni
    Biochemistry Laboratory Istituto Dermopatico Dell Immacolata, c o Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, 00133 Rome, Italy
    Proc Natl Acad Sci U S A 110:7300-5. 2013
    ....
  43. pmc Laminin α1 is essential for mouse cerebellar development
    Naoki Ichikawa-Tomikawa
    Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine, Tokyo, Japan
    Matrix Biol 31:17-28. 2012
    ..A marked reduction in numbers of dendritic processes in Purkinje cells was observed in Lama1(CKO) mice. Together, these results indicate that Lama1 is required for cerebellar development and functions...
  44. ncbi Maternal imprinting of the mouse Snrpn gene and conserved linkage homology with the human Prader-Willi syndrome region
    S E Leff
    Department of Pharmacology, Stanford University School of Medicine, California 94305
    Nat Genet 2:259-64. 1992
    ....
  45. ncbi Chromosomal assignments of mouse connexin genes, coding for gap junctional proteins, by somatic cell hybridization
    H J Schwarz
    Institut fur Genetik, Abt Molekulargenetik, Universitat Bonn, Germany
    Somat Cell Mol Genet 18:351-9. 1992
    ..In addition, our results confirm the recent assignment of mouse connexin genes Cx26, Cx32, Cx37, Cx40, Cx43, and Cx46 to mouse chromosomes 14, X, 4, 3, 10, and 14, respectively, by analysis of ..
  46. ncbi Connexin expression and gap junction communication compartments in the developing mouse limb
    D W Laird
    Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada
    Dev Dyn 195:153-61. 1992
    ..Thus, the lack of dye transfer between the ectoderm and underlying mesenchyme from the peak of AER height through its decline suggests that bulk transfer of morphogens between these two layers is not necessary for mouse limb development...
  47. ncbi Zygotic expression of the connexin43 gene supplies subunits for gap junction assembly during mouse preimplantation development
    G Valdimarsson
    Department of Zoology, University of Western Ontario, London, Canada
    Mol Reprod Dev 30:18-26. 1991
    ..We conclude that connexin43 is one member of the connexin gene family whose zygotic expression is critical for preimplantation morphogenesis...
  48. ncbi Distribution of genes for gap junction membrane channel proteins on human and mouse chromosomes
    C L Hsieh
    Howard Hughes Medical Institute, Stanford, California
    Somat Cell Mol Genet 17:191-200. 1991
    ..1-q24.1; GJB1 (connexin32) to Xcen-q22; GJB2 (connexin26) to 13; and GJA3 (connexin46) also to 13, probably near GJB2...
  49. ncbi Developmental regulation of gap junction gene expression during mouse embryonic development
    M Nishi
    Department of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, California 92037
    Dev Biol 146:117-30. 1991
    ..4) In an ES cell culture line, alpha 1 was the only gap junction gene product detected. This is consistent with the findings of alpha 1 expression in the embryonic inner cell mass region and in undifferentiated teratocarcinoma cells...
  50. ncbi Nonoverlapping expression of Cx43 and Cx26 in the mouse placenta and decidua: a pattern of gap junction gene expression differing from that in the rat
    C M Pauken
    Department of Biology, University of Pennsylvania, Philadelphia 19104 6017, USA
    Mol Reprod Dev 41:195-203. 1995
    We characterized the expression of two gap junction genes (Cx26 and Cx43) in the mouse decidua and placenta. In the decidua, in situ hybridization analysis and immunostaining studies revealed a high level of Cx43 expression...
  51. ncbi Analysis of multiple gap junction gene products in the rodent and human mammary gland
    A Pozzi
    Department of Cell Biology, Scripps Research Institute, La Jolla, California 92037, USA
    Exp Cell Res 220:212-9. 1995
    The expression and localization of three different connexins (alpha 1, Cx43; beta 1, Cx32; and beta 2, Cx26) were analyzed in human, mouse, and rat mammary glands by PCR analysis of reverse-transcribed RNA (RT-PCR) and indirect ..
  52. ncbi Expression of gap junction proteins connexin 26 and 43 is modulated during differentiation of keratinocytes in newborn mouse epidermis
    Y Kamibayashi
    Department of Dermatology, Sapporo Medical University School of Medicine, Japan
    J Invest Dermatol 101:773-8. 1993
    We examined the expression of the gap junction proteins connexin 26 (Cx26), 32 (Cx32), and 43 (Cx43) in keratinocytes of newborn mouse epidermis to elucidate which connexins are expressed in keratinocytes in intact skin of newborn mice, ..
  53. ncbi Molecular cloning, chromosomal location, and tissue-specific expression of the murine cathepsin G gene
    J W Heusel
    Department of Medicine, Jewish Hospital at Washington University Medical Center, St Louis, MO 63110
    Blood 81:1614-23. 1993
    ..Expression of this gene is detected only in the bone marrow and is restricted to a small population of early myeloid cells. These findings are consistent with the identification of the gene encoding murine CG...
  54. ncbi Assignment of connexin 26 (GJB2) and 46 (GJA3) genes to human chromosome 13q11-->q12 and mouse chromosome 14D1-E1 by in situ hybridization
    C Mignon
    INSERM U 406, Faculté de la Timone, Marseille
    Cytogenet Cell Genet 72:185-6. 1996
  55. ncbi Loss of alpha 1 connexin does not alter the prenatal differentiation of pancreatic beta cells and leads to the identification of another islet cell connexin
    A Charollais
    Department of Morphology, University of Geneva, Medical School, Centre Medical Universitaire, Switzerland
    Dev Genet 24:13-26. 1999
    ..They further provide evidence that normal and tumoral insulin-producing cells natively coexpress connexins alpha 1 and alpha 6...
  56. ncbi Role of connexin (gap junction) genes in cell growth control and carcinogenesis
    H Yamasaki
    Unit of Multistage Carcinogenesis, International Agency for Research on Cancer, Lyon, France
    C R Acad Sci III 322:151-9. 1999
    ..We have produced various dominant-negative mutants of Cx26, Cx32 and Cx43 and showed that some of them prevent the growth control exerted by the corresponding wild-type genes...
  57. ncbi Immunolocalization of connexin 26 in the developing mouse cochlea
    C M Frenz
    Department of Otolaryngology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Brain Res Brain Res Rev 32:172-80. 2000
    ..In this study, we demonstrate the temporal-spatial distribution of connexin 26 in the embryonic and early postnatal mouse cochlea...
  58. ncbi Acute-phase response and circadian expression of connexin26 are not altered in connexin32-deficient mouse liver
    A Temme
    Abteilung Molekulargenetik, Institut fur Genetik, Universitat Bonn, Germany
    Cell Tissue Res 300:111-7. 2000
    In mouse hepatocytes, the gap junctional proteins connexin32 (Cx32) and connexin26 (Cx26) are expressed in the same gap junctional plaque. Expression of the major Cx32 protein is downregulated during liver regeneration and cholestasis...
  59. ncbi The mouse gap junction gene connexin29 is highly expressed in sciatic nerve and regulated during brain development
    G Sohl
    Institut fur Genetik, Abteilung Molekulargenetik, Universitat Bonn, Germany
    Biol Chem 382:973-8. 2001
    ..Our expression data suggest that the new connexin gene is active in myelin-forming glial cells...
  60. ncbi A gene-driven approach to the identification of ENU mutants in the mouse
    Emma L Coghill
    MRC Mammalian Genetics Unit and UK Mouse Genome Centre, Harwell OX11 ORD, UK
    Nat Genet 30:255-6. 2002
    ..We provide support for this approach and report the identification of mutations in the gene (Gjb2) encoding connexin 26, using archives established from the UK ENU mutagenesis program.
  61. pmc Mouse horizontal cells do not express connexin26 or connexin36
    M R Deans
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Cell Commun Adhes 8:361-6. 2001
    ..Microscopy was used to further examine the distribution of Cx26 and Cx36...
  62. pmc Apoptosis in uterine epithelium and decidua in response to implantation: evidence for two different pathways
    Anike Joswig
    Institute of Anatomy, University Hospital of Essen, Essen, Germany
    Reprod Biol Endocrinol 1:44. 2003
    ....
  63. ncbi Connexins 26 and 30 are co-assembled to form gap junctions in the cochlea of mice
    Shoab Ahmad
    Section on Neurobiology, Leslie and Susan Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA 90057 1922, USA
    Biochem Biophys Res Commun 307:362-8. 2003
    ..Two of these connexins (Cx26 and Cx30), both belonging to the beta-group, were investigated for their molecular assemblies in the cochlea...
  64. ncbi An update on connexin genes and their nomenclature in mouse and man
    Goran Sohl
    Institut fur Genetik, Universitat Bonn, Germany
    Cell Commun Adhes 10:173-80. 2003
    ..Furthermore, this short review contains an update on phenotypic correlations between connexin deficient mice and patients bearing mutations in their orthologous connexin genes...
  65. ncbi A reporter allele for investigating connexin 26 gene expression in the mouse brain
    Mikhail A Filippov
    Department of Clinical Neurobiology, University Hospital of Neurology, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany
    Eur J Neurosci 18:3183-92. 2003
    ..In order to define the cellular distribution of connexin 26 (Cx26) in the mouse we have generated a reporter allele (Cx26lacZ) by genetically manipulating the locus so ..
  66. ncbi mRNA expression pattern of multiple members of connexin gene family in normal and abnormal fetal gonads in mouse
    Subhash C Juneja
    Department of Zoology, The University of Western Ontario, London, Canada
    Indian J Physiol Pharmacol 47:147-56. 2003
    ..5 dpc knockout (Cx43-/-) fetuses. The mRNA expression pattern of connexins (Cx26, Cx30.3, Cx31, Cx31.1, Cx32, Cx37, Cx40, Cx43, Cx45, Cx46 and Cx50) was analyzed by RT-PCR...
  67. ncbi The novel mouse connexin39 gene is expressed in developing striated muscle fibers
    Julia von Maltzahn
    Institut fur Genetik, Abteilung Molekulargenetik, Universitat Bonn, Römerstr 164, 53117 Bonn, Germany
    J Cell Sci 117:5381-92. 2004
    ..As expression of no other known connexin could be verified in these cells, intercellular dye transfer might result from functional expression of Cx39 in developing striated muscle fibers...
  68. ncbi Cx31 and Cx43 double-deficient mice reveal independent functions in murine placental and skin development
    Mark Kibschull
    Institute of Anatomy, University Hospital Duisburg Essen, Essen, Germany
    Dev Dyn 233:853-63. 2005
    ..Therefore, in epidermal and preimplantation development, gap junctional communication can probably be compensated by other isoforms coexpressed with Cx31 and Cx43...
  69. ncbi Ablation of gap junctional communication in hepatocytes of transgenic mice does not lead to disrupted cellular homeostasis or increased spontaneous tumourigenesis
    Thomas Ott
    Institut fur Genetik, Abteilung Molekulargenetik, Universitat Bonn, Römerstr 164, D 53117 Bonn, Germany
    Eur J Cell Biol 85:717-28. 2006
    Gap junctions between murine hepatocytes are composed of two subunit proteins, connexin26 (Cx26) and connexin32 (Cx32)...
  70. pmc Modulation of connexin expression and gap junction communication in astrocytes by the gram-positive bacterium S. aureus
    Nilufer Esen
    Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Glia 55:104-17. 2007
    ..Here we investigated the effects of S. aureus and its cell wall product peptidoglycan (PGN) on Cx43, Cx30, and Cx26 expression, the main Cx isoforms found in astrocytes...
  71. pmc Restoration of connexin26 protein level in the cochlea completely rescues hearing in a mouse model of human connexin30-linked deafness
    Shoeb Ahmad
    Department of Otolaryngology, Yerkes Microarray Core, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322 3030, USA
    Proc Natl Acad Sci U S A 104:1337-41. 2007
    Mutations in genes coding for connexin26 (Cx26) and/or Cx30 are linked to approximately half of all cases of human autosomal nonsyndromic prelingual deafness...
  72. ncbi Connexin levels regulate keratinocyte differentiation in the epidermis
    Stephanie Langlois
    Department of Anatomy and Cell Biology, The University of Western Ontario, London, Ontario, N6A 5C1, Canada
    J Biol Chem 282:30171-80. 2007
    ..When Cx43 expression was knocked down by 50-75%, there was a coordinate 55-65% reduction in Cx26 level, gap junction-based dye coupling was reduced by 60%, and transepithelial resistance decreased...
  73. pmc Analysis of connexin subunits required for the survival of vestibular hair cells
    Yan Qu
    Department of Otolaryngology, Emory University School of Medicine, Atlanta, Georgia 30322 3030, USA
    J Comp Neurol 504:499-507. 2007
    ..The most commonly found human Cx mutations are either Cx26 or Cx30 deletions...
  74. pmc Cooperative function of Tbx1 and Brn4 in the periotic mesenchyme is necessary for cochlea formation
    Evan M Braunstein
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Assoc Res Otolaryngol 9:33-43. 2008
    ....
  75. doi Tumor promotion in liver of mice with a conditional Cx26 knockout
    Philip Marx-Stoelting
    Institute of Pharmacology and Toxicology, Department of Toxicology, University of Tubingen, Wilhelmstr 56, 72074 Tubingen, Germany
    Toxicol Sci 103:260-7. 2008
    ..To investigate whether Cx26 plays a similar role, an initiation-promotion experiment was conducted using mice with a liver-specific knockout of ..
  76. doi Pancreatic inactivation of c-Myc decreases acinar mass and transdifferentiates acinar cells into adipocytes in mice
    Claire Bonal
    Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland
    Gastroenterology 136:309-319.e9. 2009
    ..The basic helix-loop-helix transcription factor c-Myc is one of the main regulators of these processes in many organs. We studied the requirement of c-Myc in controlling the generation and maintenance of pancreatic mass...
  77. pmc Syncytin-A knockout mice demonstrate the critical role in placentation of a fusogenic, endogenous retrovirus-derived, envelope gene
    Anne Dupressoir
    Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, Unité Mixte de Recherche 8122, Centre National de Recherche Scientifique, Institut Gustave Roussy, 94805 Villejuif, and Université Paris Sud, 91405 Orsay, France
    Proc Natl Acad Sci U S A 106:12127-32. 2009
    ....
  78. doi Expression of Pou3f3/Brn-1 and its genomic methylation in developing auditory epithelium
    Hideki Mutai
    Laboratory of Auditory Disorders, National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo, Japan
    Dev Neurobiol 69:913-30. 2009
    ..This is the first report to study involvement of an epigenetic regulatory mechanism in the developing mammalian auditory epithelium...
  79. pmc Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins
    Francisco J del Castillo
    Unite de Genetique et Physiologie de l Audition, Institut Pasteur, Paris, France
    Hum Mol Genet 19:262-75. 2010
    ..Sequence accession numbers. GenBank: Human CNST cDNA, NM_152609; mouse Cnst cDNA, NM_146105...
  80. pmc Asparagine 175 of connexin32 is a critical residue for docking and forming functional heterotypic gap junction channels with connexin26
    So Nakagawa
    Institute for Protein Research, Osaka University, Suita, Osaka, Japan
    J Biol Chem 286:19672-81. 2011
    ..Based on the crystal structure of the Cx26 gap junction channel and homology models of heterotypic channels, we analyzed docking selectivity for several ..
  81. pmc Mammalian Llgl2 is necessary for proper branching morphogenesis during placental development
    Smitha Sripathy
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Mol Cell Biol 31:2920-33. 2011
    ....
  82. pmc Connexin26 expression in brain parenchymal cells demonstrated by targeted connexin ablation in transgenic mice
    J I Nagy
    Department of Physiology, Faculty of Medicine, University of Manitoba, 745 Bannatyne Ave, Winnipeg, MB, Canada R3E 0J9
    Eur J Neurosci 34:263-71. 2011
    ..Cx30) and connexin43 (Cx43), but it has remained controversial whether these cells also express connexin26 (Cx26). To investigate this issue further, we examined immunofluorescence labelling of glial connexins in wild-type vs...
  83. doi Focal adhesion kinase modulates radial glia-dependent neuronal migration through connexin-26
    Manuel Valiente
    Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
    J Neurosci 31:11678-91. 2011
    ..These results indicate that FAK plays a fundamental role in the dynamic regulation of Gap-mediated adhesions during glial-guided neuronal migration in the mouse...
  84. doi Impaired stria vascularis integrity upon loss of E-cadherin in basal cells
    Mark Oliver Trowe
    Institut fur Molekularbiologie, OE5250, Medizinische Hochschule Hannover, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Dev Biol 359:95-107. 2011
    ....
  85. ncbi The hepatocyte-specific phenotype of murine liver cells correlates with high expression of connexin32 and connexin26 but very low expression of connexin43
    R Stutenkemper
    Institute für Genetik, Abteilung Molekulargenetik, Universitat Bonn, Germany
    Exp Cell Res 201:43-54. 1992
    ..Furthermore several dedifferentiated cell lines derived from rat or mouse liver and cultivated in serum-containing medium were found to express little connexin32 or connexin26 mRNA but relatively high levels of connexin43 mRNA...
  86. ncbi Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping
    J A Haefliger
    Department of Anatomy and Cellular Biology, Harvard Medical School, Boston, Massachusetts 02115
    J Biol Chem 267:2057-64. 1992
    ..Cx40, Cx37, and Cx33 are similar to the previously characterized Cx43 and Cx46. Cx31.1 is similar to Cx26, Cx31, and Cx32...
  87. ncbi Rapid modulation of gap junction expression in mouse mammary gland during pregnancy, lactation, and involution
    P Monaghan
    Institute of Cancer Research, Haddow Laboratories, Sutton, Surrey, United Kingdom
    J Histochem Cytochem 42:931-8. 1994
    ....
  88. ncbi Multiple members of the connexin gene family participate in preimplantation development of the mouse
    T C Davies
    Department of Zoology, University of Western Ontario, London, Canada
    Dev Genet 18:234-43. 1996
    ..The expression of multiple connexin genes during this early period of embryogenesis (when there are only two distinct cell types) raises questions about the functional significance of connexin diversity in this context...
  89. ncbi Expression of the gap junction proteins connexin31 and connexin43 correlates with communication compartments in extraembryonic tissues and in the gastrulating mouse embryo, respectively
    E Dahl
    Abt Molekulargenetik, Universitat Bonn, Germany
    J Cell Sci 109:191-7. 1996
    ..The communication boundary between those compartments may be due to incompatibility of connexin31 and connexin43 hemichannels, which do not communicate with each other in cell culture...
  90. ncbi Isolation and characterization of a bovine neural specific protein (CRMP-2) cDNA homologous to unc-33, a C. elegans gene implicated in axonal outgrowth and guidance
    T Kamata
    SAIC Frederick, IRSP, National Cancer Institute NCI FCRDC, Frederick, MD 21702, USA
    Brain Res Mol Brain Res 54:219-36. 1998
    ..Taken together, these data suggest multi-functional roles for CRMP-2 in developing and adult nervous systems, and the biological activity of CRMP-2 could be regulated by phosphorylation reaction...
  91. ncbi Gap junctions in normal and neoplastic mammary gland
    D Locke
    Institute of Cancer Research, Sutton, Surrey, U K
    J Pathol 186:343-9. 1998
    ....
  92. ncbi TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles
    T Kojima
    Department of Hematopoietic Factors, The Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    J Biol Chem 275:20742-7. 2000
    ..The Troy gene is located near the waved coat (Wc) locus, a mutant related to abnormalities in skin and hair...
  93. ncbi Exocrine specific expression of Connexin32 is dependent on the basic helix-loop-helix transcription factor Mist1
    J Michael Rukstalis
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907 1392, USA
    J Cell Sci 116:3315-25. 2003
    ..In pancreatic acini, the connexin26 (Cx26) and connexin32 (Cx32) proteins form functional channels that coordinate the secretion of digestive enzymes...
  94. ncbi An expression atlas of connexin genes in the mouse
    Annalisa Buniello
    Telethon Institute of Genetics and Medicine, Via P Castellino 111, 80131 Naples, Italy
    Genomics 83:812-20. 2004
    ....
  95. pmc Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response
    Ali R Djalilian
    National Human Genome Research Institute, National Eye Institute, and National Institute of Child Health and Development, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 116:1243-53. 2006
    ..gene expression to involved psoriatic plaques, including a significant upregulation of the gap junction protein connexin 26 (Cx26)...
  96. ncbi Oleamide derivatives suppress the spontaneous metastasis by inhibiting connexin 26
    Yusuke Ohba
    Department of Synthetic Organic Chemistry, Graduate School of Pharmaceutical Science, Osaka University, Osaka, Japan
    Int J Cancer 121:47-54. 2007
    We previously reported that overexpressing connexin 26 (Cx26) enhances the spontaneous metastasis of mouse BL6 melanoma cells...
  97. pmc Identification of connexin36 in gap junctions between neurons in rodent locus coeruleus
    J E Rash
    Department of Biomedical Sciences, Colorado State University, Campus Delivery 1617, Fort Collins, CO 80523, USA
    Neuroscience 147:938-56. 2007
    ..these neurons are linked by extraordinarily abundant gap junctions consisting of connexin32 (Cx32) and connexin26 (Cx26), and that those same connexins abundantly link neurons to astrocytes...
  98. ncbi Expression of connexins in embryonic mouse neocortical development
    Cima Cina
    Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
    J Comp Neurol 504:298-313. 2007
    ..reaction, Western blot analysis, and immunohistochemistry, we found that among the family of gap junction proteins, Cx26, Cx36, Cx37, Cx43, and Cx45 were expressed in the developing cortex of mice, Cx30 and Cx32 were absent, while Cx40 ..
  99. pmc Chromosomal localization of the mammalian peptide-methionine sulfoxide reductase gene and its differential expression in various tissues
    J Moskovitz
    Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ 07110 1199, USA
    Proc Natl Acad Sci U S A 93:3205-8. 1996
    ..In addition, blood and alveolar macrophages showed high expression of the enzyme. The msrA gene was mapped to the central region of mouse chromosome 14, in a region of homology with human chromosomes 13 and 8p21...
  100. ncbi Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts
    N Yabuta
    Department of Molecular Genetics, Department of Science for Laboratory Animal Experimentation, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Genomics 63:263-70. 2000
    ....
  101. pmc Strain background effects and genetic modifiers of hearing in mice
    Kenneth R Johnson
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Brain Res 1091:79-88. 2006
    ..Because modifier genes and digenic inheritance are not always distinguishable, we also include in this review several examples of digenic inheritance of hearing loss that have been reported in both mice and humans...

Research Grants4

  1. Zeiss LSM 510 Laser Scanning Microscope
    JOHN RASH; Fiscal Year: 2002
    ..The DIC Board of Directors will meet bi-monthly to insure continued efficient scheduling and operation of the replacement confocal microscope, to consider future upgrades, and to establish or change DIC access policies. ..
  2. Gap Junctions and Connexins in Developing CNS
    JOHN RASH; Fiscal Year: 2005
    ....
  3. Connexins in Neuronal and Glial Gap Junctions in the Central Nervous System
    JOHN RASH; Fiscal Year: 2007
    ..abstract_text> ..