Genomes and Genes
Gene Symbol: Gjb5
Description: gap junction protein, beta 5
Alias: Cnx31.1, Cx31.1, Gjb-5, gap junction beta-5 protein, connexin-31.1, gap junction membrane channel protein beta 5
- Multiple members of the connexin gene family participate in preimplantation development of the mouseT C Davies
Department of Zoology, University of Western Ontario, London, Canada
Dev Genet 18:234-43. 1996..The expression of multiple connexin genes during this early period of embryogenesis (when there are only two distinct cell types) raises questions about the functional significance of connexin diversity in this context...
- Characterization of connexin31.1-deficient mice reveals impaired placental developmentQingyi Zheng-Fischhöfer
Institut fur Genetik, Abteilung Molekulargenetik, Universitat Bonn, D 53117 Bonn, Germany
Dev Biol 312:258-71. 2007..We conclude that Connexin31.1 is critical for normal placental development but appears to be functionally compensated by other connexin isoforms in the embryo proper and adult mouse...
- Connexin31.1 deficiency in the mouse impairs object memory and modulates open-field exploration, acetylcholine esterase levels in the striatum, and cAMP response element-binding protein levels in the striatum and piriform cortexE Dere
Institute of Physiological Psychology, Center for Biological and Medical Research, University of Dusseldorf, Universitatsstrasse 1, Dusseldorf, Germany
Neuroscience 153:396-405. 2008..In conclusion, gap-junctions featuring the Cx31.1 protein might be involved in open-field exploration as well as object memory and modulate levels of AChE and CREB in the striatum and piriform cortex...
- Connexin31.1 (Gjb5) deficiency blocks trophoblast stem cell differentiation and delays placental developmentMark Kibschull
1 Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada
Stem Cells Dev 23:2649-60. 2014The gap junction channel forming connexins (Cx) Cx31 (Gjb3) and Cx31.1 (Gjb5) are co-expressed in the mouse trophoblast lineage...
- Two gap junction genes, connexin 31.1 and 30.3, are closely linked on mouse chromosome 4 and preferentially expressed in skinH Hennemann
Abteilung Molekulargenetik, Universitat Bonn, Germany
J Biol Chem 267:17225-33. 1992..Microinjection of Cx30.3, but not Cx31.1 cRNA, into Xenopus oocyte pairs induced formation of functional gap junction channels with unique voltage-gated parameters compared to other connexins expressed similarly...
- Mutations in the human connexin gene GJB3 cause erythrokeratodermia variabilisG Richard
Genetic Studies Section, Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA
Nat Genet 20:366-9. 1998..of epidermally expressed connexin genes led us to characterize the human homologues of GJB3 (encoding Cx31) and GJB5 (encoding Cx31.1). GJB3, GJB5 and GJA4 were localized to a 1.1-Mb YAC in the candidate interval...
- Two interactive genes responsible for a new inherited cataract (RCT) in the mouseY Y Maeda
The Tokyo Metropolitan Institute of Medical Science Rinshoken, Dept of Laboratory Animal Science, Japan
Mamm Genome 12:278-83. 2001..The rct locus essential for the onset of the cataract was tightly linked to D4Mit278 on Chromosome (Chr) 4 with no recombination. The mrct locus was closely linked to D5Mit239 (chi2 = 66.3, P << 0.00001) on Chr 5...
- Functional significance of gap junctional coupling in preimplantation developmentF D Houghton
Department of Physiology, Dental Sciences Building, The University of Western Ontario, London, Ontario, Canada N6A 5C1
Biol Reprod 66:1403-12. 2002..New evidence of this diversification is presented using rat blastocyst outgrowths...
- Expression profiles of the connexin genes, Gjb1 and Gjb3, in the developing mouse cochleaNuria Lopez-Bigas
Genes and Disease Program, Centre de Regulacio Genomica, Barcelona, Spain
Mech Dev 119:S111-5. 2002..In the adult cochlea Gjb1 transcripts disappeared while Gjb3 expression remained present in fibrocytes with specific expression patterns...
- An update on connexin genes and their nomenclature in mouse and manGoran Sohl
Institut fur Genetik, Universitat Bonn, Germany
Cell Commun Adhes 10:173-80. 2003..Furthermore, this short review contains an update on phenotypic correlations between connexin deficient mice and patients bearing mutations in their orthologous connexin genes...
- An expression atlas of connexin genes in the mouseAnnalisa Buniello
Telethon Institute of Genetics and Medicine, Via P Castellino 111, 80131 Naples, Italy
Genomics 83:812-20. 2004....
- mRNA expression pattern of multiple members of connexin gene family in normal and abnormal fetal gonads in mouseSubhash C Juneja
Department of Zoology, The University of Western Ontario, London, Canada
Indian J Physiol Pharmacol 47:147-56. 2003..In developmentally impaired fetal ovary, only Cx43 was not expressed as expected but other three connexins were expresed. The study may be useful in interpreting human testis defects in infertility cases...
- The novel mouse connexin39 gene is expressed in developing striated muscle fibersJulia von Maltzahn
Institut fur Genetik, Abteilung Molekulargenetik, Universitat Bonn, Römerstr 164, 53117 Bonn, Germany
J Cell Sci 117:5381-92. 2004..As expression of no other known connexin could be verified in these cells, intercellular dye transfer might result from functional expression of Cx39 in developing striated muscle fibers...
- Cx31 and Cx43 double-deficient mice reveal independent functions in murine placental and skin developmentMark Kibschull
Institute of Anatomy, University Hospital Duisburg Essen, Essen, Germany
Dev Dyn 233:853-63. 2005..Therefore, in epidermal and preimplantation development, gap junctional communication can probably be compensated by other isoforms coexpressed with Cx31 and Cx43...
- Novel gene expression patterns along the proximo-distal axis of the mouse embryo before gastrulationStephen Frankenberg
The Wellcome Trust Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, Tennis Court Rd, Cambridge, UK
BMC Dev Biol 7:8. 2007..5. At E5.5, prospective anterior markers are expressed at the distal tip of the embryo, whereas prospective posterior markers are expressed more proximally, close to the boundary with the extraembryonic region...
- Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mappingJ A Haefliger
Department of Anatomy and Cellular Biology, Harvard Medical School, Boston, Massachusetts 02115
J Biol Chem 267:2057-64. 1992..Chromosomal mapping studies indicate that Cx26 and Cx46 are tightly linked on chromosome 14, and Cx37 and Cx31.1 are linked on chromosome 4, while the rest of the connexin genes are dispersed...
- CLINICAL AND GENETIC STUDIES OF NETHERTON SYNDROMEGabriele Richard; Fiscal Year: 2002....
- CONNEXINS AND THEIR ROLE IN EPIDERMAL DIFFERENTIATIONGabriele Richard; Fiscal Year: 2004..variabilis (EKV) that recently resulted in the cloning of two novel human connexin genes, GJB3 and GJB5, and the disclosure of mutations in GJB3 as proximal cause of EKV...