Gjb5

Summary

Gene Symbol: Gjb5
Description: gap junction protein, beta 5
Alias: Cnx31.1, Cx31.1, Gjb-5, gap junction beta-5 protein, connexin-31.1, gap junction membrane channel protein beta 5
Species: mouse

Top Publications

  1. ncbi Multiple members of the connexin gene family participate in preimplantation development of the mouse
    T C Davies
    Department of Zoology, University of Western Ontario, London, Canada
    Dev Genet 18:234-43. 1996
  2. ncbi Characterization of connexin31.1-deficient mice reveals impaired placental development
    Qingyi Zheng-Fischhöfer
    Institut fur Genetik, Abteilung Molekulargenetik, Universitat Bonn, D 53117 Bonn, Germany
    Dev Biol 312:258-71. 2007
  3. doi Connexin31.1 deficiency in the mouse impairs object memory and modulates open-field exploration, acetylcholine esterase levels in the striatum, and cAMP response element-binding protein levels in the striatum and piriform cortex
    E Dere
    Institute of Physiological Psychology, Center for Biological and Medical Research, University of Dusseldorf, Universitatsstrasse 1, Dusseldorf, Germany
    Neuroscience 153:396-405. 2008
  4. pmc Connexin31.1 (Gjb5) deficiency blocks trophoblast stem cell differentiation and delays placental development
    Mark Kibschull
    1 Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada
    Stem Cells Dev 23:2649-60. 2014
  5. ncbi Two gap junction genes, connexin 31.1 and 30.3, are closely linked on mouse chromosome 4 and preferentially expressed in skin
    H Hennemann
    Abteilung Molekulargenetik, Universitat Bonn, Germany
    J Biol Chem 267:17225-33. 1992
  6. ncbi Mutations in the human connexin gene GJB3 cause erythrokeratodermia variabilis
    G Richard
    Genetic Studies Section, Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 20:366-9. 1998
  7. ncbi Two interactive genes responsible for a new inherited cataract (RCT) in the mouse
    Y Y Maeda
    The Tokyo Metropolitan Institute of Medical Science Rinshoken, Dept of Laboratory Animal Science, Japan
    Mamm Genome 12:278-83. 2001
  8. ncbi Functional significance of gap junctional coupling in preimplantation development
    F D Houghton
    Department of Physiology, Dental Sciences Building, The University of Western Ontario, London, Ontario, Canada N6A 5C1
    Biol Reprod 66:1403-12. 2002
  9. ncbi Expression profiles of the connexin genes, Gjb1 and Gjb3, in the developing mouse cochlea
    Nuria Lopez-Bigas
    Genes and Disease Program, Centre de Regulacio Genomica, Barcelona, Spain
    Mech Dev 119:S111-5. 2002
  10. ncbi An update on connexin genes and their nomenclature in mouse and man
    Goran Sohl
    Institut fur Genetik, Universitat Bonn, Germany
    Cell Commun Adhes 10:173-80. 2003

Research Grants

  1. CLINICAL AND GENETIC STUDIES OF NETHERTON SYNDROME
    Gabriele Richard; Fiscal Year: 2002
  2. CONNEXINS AND THEIR ROLE IN EPIDERMAL DIFFERENTIATION
    Gabriele Richard; Fiscal Year: 2004

Scientific Experts

  • Ekrem Dere
  • Subhash C Juneja
  • Y Y Maeda
  • G Richard
  • Stephen Frankenberg
  • Mark Kibschull
  • Elke Winterhager
  • Klaus Willecke
  • Stephen J Lye
  • Goran Sohl
  • Qingyi Zheng-Fischhöfer
  • Annalisa Buniello
  • Julia von Maltzahn
  • Elzbieta Matysiak-Zablocki
  • Keith Colaco
  • F D Houghton
  • Nuria Lopez-Bigas
  • G M Kidder
  • K J Barr
  • Harald Reucher
  • Elisabeth Petrasch-Parwez
  • Marc Schnichels
  • Markus Kretz
  • Jörg Strotmann
  • James I Nagy
  • Bruce D Lynn
  • Otto Traub
  • Thomas M Magin
  • Stefano Volinia
  • Paolo Gasparini
  • Carsten Euwens
  • Donatella Montanaro
  • Valeria Marigo
  • H D Gabriel
  • E Winterhager
  • Maria L Arbones
  • R Grummer
  • T C Davies
  • G Walter
  • O Traub
  • H J Leese
  • Lionel Simonneau
  • Xavier Estivill
  • D H Jones
  • D Zhu
  • J A Haefliger
  • H Hennemann
  • J B White
  • N G Copeland
  • D L Paul
  • N A Jenkins
  • D J Gilbert
  • R Bruzzone
  • S Chang
  • B J Nicholson
  • K Willecke
  • P A Lalley
  • E Dahl
  • H J Schwarz

Detail Information

Publications16

  1. ncbi Multiple members of the connexin gene family participate in preimplantation development of the mouse
    T C Davies
    Department of Zoology, University of Western Ontario, London, Canada
    Dev Genet 18:234-43. 1996
    ..The expression of multiple connexin genes during this early period of embryogenesis (when there are only two distinct cell types) raises questions about the functional significance of connexin diversity in this context...
  2. ncbi Characterization of connexin31.1-deficient mice reveals impaired placental development
    Qingyi Zheng-Fischhöfer
    Institut fur Genetik, Abteilung Molekulargenetik, Universitat Bonn, D 53117 Bonn, Germany
    Dev Biol 312:258-71. 2007
    ..We conclude that Connexin31.1 is critical for normal placental development but appears to be functionally compensated by other connexin isoforms in the embryo proper and adult mouse...
  3. doi Connexin31.1 deficiency in the mouse impairs object memory and modulates open-field exploration, acetylcholine esterase levels in the striatum, and cAMP response element-binding protein levels in the striatum and piriform cortex
    E Dere
    Institute of Physiological Psychology, Center for Biological and Medical Research, University of Dusseldorf, Universitatsstrasse 1, Dusseldorf, Germany
    Neuroscience 153:396-405. 2008
    ..In conclusion, gap-junctions featuring the Cx31.1 protein might be involved in open-field exploration as well as object memory and modulate levels of AChE and CREB in the striatum and piriform cortex...
  4. pmc Connexin31.1 (Gjb5) deficiency blocks trophoblast stem cell differentiation and delays placental development
    Mark Kibschull
    1 Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada
    Stem Cells Dev 23:2649-60. 2014
    The gap junction channel forming connexins (Cx) Cx31 (Gjb3) and Cx31.1 (Gjb5) are co-expressed in the mouse trophoblast lineage...
  5. ncbi Two gap junction genes, connexin 31.1 and 30.3, are closely linked on mouse chromosome 4 and preferentially expressed in skin
    H Hennemann
    Abteilung Molekulargenetik, Universitat Bonn, Germany
    J Biol Chem 267:17225-33. 1992
    ..Microinjection of Cx30.3, but not Cx31.1 cRNA, into Xenopus oocyte pairs induced formation of functional gap junction channels with unique voltage-gated parameters compared to other connexins expressed similarly...
  6. ncbi Mutations in the human connexin gene GJB3 cause erythrokeratodermia variabilis
    G Richard
    Genetic Studies Section, Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 20:366-9. 1998
    ..of epidermally expressed connexin genes led us to characterize the human homologues of GJB3 (encoding Cx31) and GJB5 (encoding Cx31.1). GJB3, GJB5 and GJA4 were localized to a 1.1-Mb YAC in the candidate interval...
  7. ncbi Two interactive genes responsible for a new inherited cataract (RCT) in the mouse
    Y Y Maeda
    The Tokyo Metropolitan Institute of Medical Science Rinshoken, Dept of Laboratory Animal Science, Japan
    Mamm Genome 12:278-83. 2001
    ..The rct locus essential for the onset of the cataract was tightly linked to D4Mit278 on Chromosome (Chr) 4 with no recombination. The mrct locus was closely linked to D5Mit239 (chi2 = 66.3, P << 0.00001) on Chr 5...
  8. ncbi Functional significance of gap junctional coupling in preimplantation development
    F D Houghton
    Department of Physiology, Dental Sciences Building, The University of Western Ontario, London, Ontario, Canada N6A 5C1
    Biol Reprod 66:1403-12. 2002
    ..New evidence of this diversification is presented using rat blastocyst outgrowths...
  9. ncbi Expression profiles of the connexin genes, Gjb1 and Gjb3, in the developing mouse cochlea
    Nuria Lopez-Bigas
    Genes and Disease Program, Centre de Regulacio Genomica, Barcelona, Spain
    Mech Dev 119:S111-5. 2002
    ..In the adult cochlea Gjb1 transcripts disappeared while Gjb3 expression remained present in fibrocytes with specific expression patterns...
  10. ncbi An update on connexin genes and their nomenclature in mouse and man
    Goran Sohl
    Institut fur Genetik, Universitat Bonn, Germany
    Cell Commun Adhes 10:173-80. 2003
    ..Furthermore, this short review contains an update on phenotypic correlations between connexin deficient mice and patients bearing mutations in their orthologous connexin genes...
  11. ncbi An expression atlas of connexin genes in the mouse
    Annalisa Buniello
    Telethon Institute of Genetics and Medicine, Via P Castellino 111, 80131 Naples, Italy
    Genomics 83:812-20. 2004
    ....
  12. ncbi mRNA expression pattern of multiple members of connexin gene family in normal and abnormal fetal gonads in mouse
    Subhash C Juneja
    Department of Zoology, The University of Western Ontario, London, Canada
    Indian J Physiol Pharmacol 47:147-56. 2003
    ..In developmentally impaired fetal ovary, only Cx43 was not expressed as expected but other three connexins were expresed. The study may be useful in interpreting human testis defects in infertility cases...
  13. ncbi The novel mouse connexin39 gene is expressed in developing striated muscle fibers
    Julia von Maltzahn
    Institut fur Genetik, Abteilung Molekulargenetik, Universitat Bonn, Römerstr 164, 53117 Bonn, Germany
    J Cell Sci 117:5381-92. 2004
    ..As expression of no other known connexin could be verified in these cells, intercellular dye transfer might result from functional expression of Cx39 in developing striated muscle fibers...
  14. ncbi Cx31 and Cx43 double-deficient mice reveal independent functions in murine placental and skin development
    Mark Kibschull
    Institute of Anatomy, University Hospital Duisburg Essen, Essen, Germany
    Dev Dyn 233:853-63. 2005
    ..Therefore, in epidermal and preimplantation development, gap junctional communication can probably be compensated by other isoforms coexpressed with Cx31 and Cx43...
  15. pmc Novel gene expression patterns along the proximo-distal axis of the mouse embryo before gastrulation
    Stephen Frankenberg
    The Wellcome Trust Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, Tennis Court Rd, Cambridge, UK
    BMC Dev Biol 7:8. 2007
    ..5. At E5.5, prospective anterior markers are expressed at the distal tip of the embryo, whereas prospective posterior markers are expressed more proximally, close to the boundary with the extraembryonic region...
  16. ncbi Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping
    J A Haefliger
    Department of Anatomy and Cellular Biology, Harvard Medical School, Boston, Massachusetts 02115
    J Biol Chem 267:2057-64. 1992
    ..Chromosomal mapping studies indicate that Cx26 and Cx46 are tightly linked on chromosome 14, and Cx37 and Cx31.1 are linked on chromosome 4, while the rest of the connexin genes are dispersed...

Research Grants2

  1. CLINICAL AND GENETIC STUDIES OF NETHERTON SYNDROME
    Gabriele Richard; Fiscal Year: 2002
    ....
  2. CONNEXINS AND THEIR ROLE IN EPIDERMAL DIFFERENTIATION
    Gabriele Richard; Fiscal Year: 2004
    ..variabilis (EKV) that recently resulted in the cloning of two novel human connexin genes, GJB3 and GJB5, and the disclosure of mutations in GJB3 as proximal cause of EKV...