Genomes and Genes
Gene Symbol: Gjb6
Description: gap junction protein, beta 6
Alias: AA958971, Cx30, D14Bwg0506e, gap junction beta-6 protein, connexin-30, gap junction membrane channel protein beta 6
- Connexin30 deficiency causes instrastrial fluid-blood barrier disruption within the cochlear stria vascularisMartine Cohen-Salmon
Unité de Génétique des Déficits Sensoriels, Unité Mixte de Recherche S 587, Institut National de la Sante et de la Recherche Medicale, 75724 Paris Cedex 15, France
Proc Natl Acad Sci U S A 104:6229-34. 2007..The absence of the gap junction protein connexin30 (Cx30) in Cx30(-/-) mice results in the SV failure to produce an EP, which mainly accounts for the severe congenital ..
- Astroglial networks scale synaptic activity and plasticityUlrike Pannasch
Centre National de la Recherche Scientifique Unité Mixte de Recherche 7241 Institut National de la Santé et de la Recherche Médicale U1050, College de France, 75005 Paris, France
Proc Natl Acad Sci U S A 108:8467-72. 2011..Although the gap junction proteins connexin 30 (Cx30) and connexin 43 (Cx43) mediate the extensive network organization of astrocytes, their role in synaptic ..
- Restoration of connexin26 protein level in the cochlea completely rescues hearing in a mouse model of human connexin30-linked deafnessShoeb Ahmad
Department of Otolaryngology, Yerkes Microarray Core, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322 3030, USA
Proc Natl Acad Sci U S A 104:1337-41. 2007Mutations in genes coding for connexin26 (Cx26) and/or Cx30 are linked to approximately half of all cases of human autosomal nonsyndromic prelingual deafness...
- The impact of astrocytic gap junctional coupling on potassium buffering in the hippocampusAnke Wallraff
Department of Experimental Neurobiology, Neurosurgery, University of Bonn, 53105 Bonn, Germany
J Neurosci 26:5438-47. 2006..In general, a surprisingly large capacity for K+ clearance was conserved in mice with coupling-deficient astrocytes, indicating that gap junction-dependent processes only partially account for K+ buffering in the hippocampus...
- Gap junction-mediated intercellular biochemical coupling in cochlear supporting cells is required for normal cochlear functionsYanping Zhang
Department of Otolaryngology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322 3030, USA
Proc Natl Acad Sci U S A 102:15201-6. 2005Dysfunction of gap junctions (GJs) caused by mutations in connexin26 (Cx26) and Cx30 accounts for nearly half of all cases of hereditary nonsyndromic deafness cases...
- Quality control of astrocyte-directed Cre transgenic mice: the benefits of a direct link between loss of gene expression and reporter activationRobert Pascal Requardt
Institute of Genetics, Division of Molecular Genetics, University of Bonn, D 53117 Bonn, Germany
Glia 57:680-92. 2009..We present several strategies to control for the fidelity of hGFAP-Cre mediated recombination. (c) 2008 Wiley-Liss, Inc...
- ATP release through connexin hemichannels and gap junction transfer of second messengers propagate Ca2+ signals across the inner earFabio Anselmi
Foundation for Advanced Biomedical Research, Venetian Institute of Molecular Medicine, 35129 Padua, Italy
Proc Natl Acad Sci U S A 105:18770-5. 2008..By contrast, Ca(2+) responses failed to propagate in cultures with defective expression of connexin 26 (Cx26) or Cx30. A companion paper demonstrates that, if expression of either Cx26 or Cx30 is blocked, expression of the other is ..
- Cochlear gap junctions coassembled from Cx26 and 30 show faster intercellular Ca2+ signaling than homomeric counterpartsJianjun Sun
Section on Neurobiology, Leslie and Susan Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, California, USA
Am J Physiol Cell Physiol 288:C613-23. 2005..However, it is still unclear how Cxs contribute to the cochlear function. Recent data (33) obtained from Cx30 knockout mice showing that a reduction of Cx diversity in assembling gap junctions is sufficient to cause deafness ..
- Coordinated control of connexin 26 and connexin 30 at the regulatory and functional level in the inner earSaida Ortolano
Venetian Institute of Molecular Medicine, Foundation for Advanced Biomedical Research, 35129 Padua, Italy
Proc Natl Acad Sci U S A 105:18776-81. 2008Connexin 26 (Cx26) and connexin 30 (Cx30) are encoded by two genes (GJB2 and GJB6, respectively) that are found within 50 kb in the same complex deafness locus, DFNB1...
- Astroglial metabolic networks sustain hippocampal synaptic transmissionNathalie Rouach
Inserm U840, College de France, 11 place Marcelin Berthelot, 75005 Paris, France
Science 322:1551-5. 2008..These results indicate that astroglial gap junctions provide an activity-dependent intercellular pathway for the delivery of energetic metabolites from blood vessels to distal neurons...
- Gap junctions in the inner ear: comparison of distribution patterns in different vertebrates and assessement of connexin composition in mammalsAndrew Forge
UCL Centre for Auditory Research and Institute of Laryngology and Otology, University College London, London WC1X 8EE, United Kingdom
J Comp Neurol 467:207-31. 2003..mammalian inner ear by RT-PCR, Western blotting, and immunohistochemistry revealed four connexin isotypes, cx26, cx30, cx31, and cx43, in the cochlea and three, cx26, cx30, and cx43, in the vestibular organs...
- Connexins 26 and 30 are co-assembled to form gap junctions in the cochlea of miceShoab Ahmad
Section on Neurobiology, Leslie and Susan Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA 90057 1922, USA
Biochem Biophys Res Commun 307:362-8. 2003..Two of these connexins (Cx26 and Cx30), both belonging to the beta-group, were investigated for their molecular assemblies in the cochlea...
- Connexin expression by radial glia-like cells is required for neurogenesis in the adult dentate gyrusAlbrecht Kunze
Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Proc Natl Acad Sci U S A 106:11336-41. 2009..Neuronal precursors were not coupled. Mice lacking Cx30 and Cx43 in GFAP-positive cells displayed almost complete inhibition of proliferation and a significant decline in ..
- Connexin30 null and conditional connexin26 null mice display distinct pattern and time course of cellular degeneration in the cochleaYu Sun
Department of Otolaryngology, Emory University School of Medicine, Atlanta, GA 30322 3030, USA
J Comp Neurol 516:569-79. 2009Mutations in connexin26 (Cx26) and Cx30 are the most common cause of nonsyndromic inherited deafness in humans...
- Role of astroglial connexin30 in hippocampal gap junction couplingDominic Gosejacob
Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, 53105 Bonn, Germany
Glia 59:511-9. 2011The impact of connexin30 (Cx30) on interastrocytic gap junction coupling in the normal hippocampus is matter of debate; reporter gene analyses indicated a weak expression of Cx30 in the mouse hippocampus...
- Connexin30 (Gjb6)-deficiency causes severe hearing impairment and lack of endocochlear potentialBarbara Teubner
Institut fur Genetik, Abteilung Molekulargenetik, Universitat Bonn, Bonn, Germany
Hum Mol Genet 12:13-21. 2003The gap junction protein connexin30 (Cx30) is expressed in a variety of tissues that include epithelial and mesenchymal structures of the inner ear. We generated Cx30 (Gjb6) deficient mice by deletion of the Cx30 coding region...
- Astrocytic Cx43 and Cx30 differentially modulate adult neurogenesis in miceMarie Liebmann
Hans Berger Department of Neurology, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany
Neurosci Lett 545:40-5. 2013..The aim of this study was to determine whether loss of the main astrocytic connexins, connexin 43 (Cx43) or connexin 30 (Cx30), influences various stages of adult hippocampal neurogenesis...
- Connexin30-mediated intercellular communication plays an essential role in epithelial repair in the cochleaAndrew Forge
Centre for Auditory Research, UCL Ear Institute, London WC1X 8EE, UK
J Cell Sci 126:1703-12. 2013..Gap junctions in which Cx30 is the predominant connexin are large and numerous between supporting cells...
- Connexin dynamics in the privileged wound healing of the buccal mucosaNicola G Davis
Department of Cell and Developmental Biology, University College London, London, United Kingdom
Wound Repair Regen 21:571-8. 2013..This rapid down-regulation of all three connexins may in part underlie the rapid healing of the buccal mucosa. ..
- The psychostimulant modafinil enhances gap junctional communication in cortical astrocytesXinhe Liu
College de France, Center for Interdisciplinary Research in Biology CIRB, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7241, Institut National de la Santé et de la Recherche Médicale Unité 1050, 75231 Paris Cedex 05, France University Pierre et Marie Curie, ED, n 158, 75005 Paris, France MEMOLIFE Laboratory of Excellence and Paris Science Lettre Research University, 75005 Paris, France
Neuropharmacology 75:533-8. 2013..We report that in the cortex modafinil injection increases the expression of mRNA and protein of connexin 30 but not those of connexin 43, the other major astroglial connexin...
- Connexin-Mediated Signaling in Nonsensory Cells Is Crucial for the Development of Sensory Inner Hair Cells in the Mouse CochleaStuart L Johnson
Department of Biomedical Science, University of Sheffield, S10 2TN Sheffield, United Kingdom
J Neurosci 37:258-268. 2017Mutations in the genes encoding for gap junction proteins connexin 26 (Cx26) and connexin 30 (Cx30) have been linked to syndromic and nonsyndromic hearing loss in mice and humans...
- Astroglial potassium clearance contributes to short-term plasticity of synaptically evoked currents at the tripartite synapseJérémie Sibille
N Rouach Neuroglial Interactions in Cerebral Physiopathology, College de France, CIRB, CNRS UMR 7241, INSERM U1050, 11, place Marcelin Berthelot, 75005 Paris, France
J Physiol 592:87-102. 2014..These results show that astrocytes integrate synaptic activity via multiple ionic channels and transporters and contribute to short-term plasticity in part via potassium clearance mediated by Kir4.1 channels...
- Mutations in Cx30 that are linked to skin disease and non-syndromic hearing loss exhibit several distinct cellular pathologiesAmy C Berger
Department of Physiology and Pharmacology, University of Western Ontario, London, ON N6A 5C1, Canada
J Cell Sci 127:1751-64. 2014b>Connexin 30 (Cx30), a member of the large gap-junction protein family, plays a role in the homeostasis of the epidermis and inner ear through gap junctional intercellular communication (GJIC)...
- Rapid sodium signaling couples glutamate uptake to breakdown of ATP in perivascular astrocyte endfeetJulia Langer
Faculty of Mathematics and Natural Sciences, Institute of Neurobiology, Heinrich Heine University Duesseldorf, Universitatsstrasse 1, Duesseldorf, D 40225, Germany
Glia 65:293-308. 2017..of ∼120 µm/s and directly propagated from stimulated into neighboring endfeet; this spread was omitted in Cx30/Cx43 double-deficient mice...
- Astroglial Connexin 43 Hemichannels Modulate Olfactory Bulb Slow OscillationsLisa Roux
Center for Interdisciplinary Research in Biology, Collège de France Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7241, Institut National de la Santé et de la Recherche Médicale U1050, 75231 Paris Cedex 05, France, University Pierre et Marie Curie, 75005 Paris, France, MemoLife Laboratory of Excellence and Paris Science Lettre Research University, 75005 Paris, France
J Neurosci 35:15339-52. 2015..These results highlight a new mechanism of neuroglial interaction in the olfactory bulb, where astrocyte connexin hemichannels are both targets and modulators of neuronal circuit function...
- Isoform-specific phosphorylation-dependent regulation of connexin hemichannelsJette Skov Alstrøm
Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark and
J Neurophysiol 114:3014-22. 2015..Connexin (Cx)43 and Cx30 are the major astrocytic connexins...
- Pannexin1 channels dominate ATP release in the cochlea ensuring endocochlear potential and auditory receptor potential generation and hearingJin Chen
1 Department of Otolaryngology, University of Kentucky Medical Center, 800 Rose Street, Lexington, Kentucky, 40536, USA 2 Department of Otolaryngology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, P R of China
Sci Rep 5:10762. 2015..Moreover, defect of connexin hemichannels by deletion of connexin26 (Cx26) and Cx30, which are predominant connexin isoforms in the cochlea, did not reduce ATP release under physiological conditions...
- Activated microglia impairs neuroglial interaction by opening Cx43 hemichannels in hippocampal astrocytesVeronica Abudara
College de France, Center for Interdisciplinary Research in Biology CIRB Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7241 Institut National de la Santé et de la Recherche Médicale U1050, Paris Cedex, France University Pierre et Marie Curie, ED, Paris, France MEMOLIFE Laboratory of Excellence and Paris Science Lettre Research University, Paris, France Departamento de Fisiología, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay
Glia 63:795-811. 2015..As a whole our findings point out astroglial hemichannels as key determinants of the impairment of synaptic transmission during neuroinflammation...
- Characterization of Panglial Gap Junction Networks in the Thalamus, Neocortex, and Hippocampus Reveals a Unique Population of Glial CellsStephanie Griemsmann
Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, 53105 Bonn, Germany
Cereb Cortex 25:3420-33. 2015..Cxs), semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) and western blotting showed that Cx30 is the dominant astrocytic Cx in the thalamus...
- Expression of zonula occludens-1 (ZO-1) and the transcription factor ZO-1-associated nucleic acid-binding protein (ZONAB)-MsY3 in glial cells and colocalization at oligodendrocyte and astrocyte gap junctions in mouse brainMihai C Penes
Department of Physiology, Faculty of Medicine, University of Manitoba, 730 William Ave, Winnipeg, Manitoba R3E 3J7, Canada
Eur J Neurosci 22:404-18. 2005..with astrocytic connexins by confocal immunofluorescence demonstration of ZO-1 colocalization with astrocytic Cx30 and Cx43, and by ZO-1 coimmunoprecipitation with Cx30 and Cx43...
- Assembly of the cochlear gap junction macromolecular complex requires connexin 26Kazusaku Kamiya
J Clin Invest 124:1598-607. 2014..Surprisingly, CX26 deficiency is not compensated for by the closely related connexin CX30, which is abundantly expressed in the same cochlear cells...
- Deafness induced by Connexin 26 (GJB2) deficiency is not determined by endocochlear potential (EP) reduction but is associated with cochlear developmental disordersJin Chen
Dept of Otolaryngology, University of Kentucky Medical School, Lexington, KY 40536, USA Department of Otolaryngology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China
Biochem Biophys Res Commun 448:28-32. 2014..These data suggest that congenital deafness induced by Cx26 deficiency is not determined by EP reduction and may result from cochlear developmental disorders...
- Connexin 30 sets synaptic strength by controlling astroglial synapse invasionUlrike Pannasch
1 Center for Interdisciplinary Research in Biology, College de France, INSERM U1050, CNRS UMR 7241, Labex Memolife, PSL Research University, Paris, France 2 Doctoral school N 158, Pierre and Marie Curie University, Paris, France 3
Nat Neurosci 17:549-58. 2014Astrocytes play active roles in brain physiology by dynamic interactions with neurons. Connexin 30, one of the two main astroglial gap-junction subunits, is thought to be involved in behavioral and basic cognitive processes...
- Fast structural responses of gap junction membrane domains to AB5 toxinsIrina V Majoul
Institute of Biology, Center for Structural and Cell Biology in Medicine, University of Lubeck, 23562 Lübeck, Germany
Proc Natl Acad Sci U S A 110:E4125-33. 2013..Our data demonstrate very fast dynamics (in the millisecond-to-second range) within GJ plaques, which previously were considered to be relatively stable, long-lived structures...
- Ablation of connexin30 in transgenic mice alters expression patterns of connexin26 and connexin32 in glial cells and leptomeningesB D Lynn
Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Eur J Neurosci 34:1783-93. 2011Expression of connexin26 (Cx26), Cx30 and Cx43 in astrocytes and expression of Cx29, Cx32 and Cx47 in oligodendrocytes of adult rodent brain has been well documented, as has the interdependence of connexin expression patterns of ..
- Early developmental expression of connexin26 in the cochlea contributes to its dominate functional role in the cochlear gap junctionsYan Qu
Department of Ear Nose and Throat, Third Hospital and Bethune International Peace Hospital of Hebei Medical University, Shijiazhuang, Hebei, People s Republic of China
Biochem Biophys Res Commun 417:245-50. 2012Mutations in Gjb2 and Gjb6 genes, coding for connexin26 (Cx26) and Cx30 proteins, respectively, are linked to about half of all cases of human autosomal non-syndromic prelingual deafness...
- Loss of astrocyte connexins 43 and 30 does not significantly alter susceptibility or severity of acute experimental autoimmune encephalomyelitis in miceSarah E Lutz
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA
J Neuroimmunol 245:8-14. 2012We showed previously that mice deficient in astrocyte gap junctions Cx43 and Cx30 exhibit white matter vacuolation and hypomyelination...
- Critical role of connexin 43 in secondary expansion of traumatic spinal cord injuryChunlan Huang
Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester, Rochester, New York 14642, USA
J Neurosci 32:3333-8. 2012..for astrocytic ATP release, we here evaluated the impact on post-traumatic ATP release of deletion of connexins (Cx30/Cx43) in astrocytes...
- Purinergic inhibition of ENaC produces aldosterone escapeJames D Stockand
Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
J Am Soc Nephrol 21:1903-11. 2010..These data suggest that control of ENaC by purinergic signaling is necessary for aldosterone escape...
- Deletion of astroglial connexins weakens the blood-brain barrierPascal Ezan
Center for Interdisciplinary Research in Biology Centre National de la Recherche Scientifique, College de France, Unité Mixte de Recherche 7241 Institut National de la Santé et de la Recherche Médicale U1050, Paris, France
J Cereb Blood Flow Metab 32:1457-67. 2012..striking properties of astrocyte endfeet is their enrichment in gap junction protein connexins 43 and 30 (Cx43 and Cx30) allowing for direct intercellular trafficking of ions and small signaling molecules through perivascular ..
- Panglial gap junctional communication is essential for maintenance of myelin in the CNSOliver Tress
Institute of Genetics, Division of Molecular Genetics, University of Bonn, 53117 Bonn, Germany
J Neurosci 32:7499-518. 2012In this study, we have investigated the contribution of oligodendrocytic connexin47 (Cx47) and astrocytic Cx30 to panglial gap junctional networks as well as myelin maintenance and function by deletion of both connexin coding DNAs in mice...
- Dual reporter approaches for identification of Cre efficacy and astrocyte heterogeneityJoachim Degen
Life and Medical Sciences Institute, Medical Faculty, University of Bonn, Bonn, Germany
FASEB J 26:4576-83. 2012..Analysis of a newly generated Cx43 knock-in ECFP mouse revealed an unexpected heterogeneity of Cx43-expressing astrocytes across brain areas...
- Reduced phosphatidylinositol 4,5-bisphosphate synthesis impairs inner ear Ca2+ signaling and high-frequency hearing acquisitionLaura Rodriguez
Istituto Veneto di Medicina Molecolare, Fondazione per la Ricerca Biomedica Avanzata, 35129 Padua, Italy
Proc Natl Acad Sci U S A 109:14013-8. 2012..This mouse model also suggests that PIPKIγ may determine the level of gap junction contribution to cochlear development...
- Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injuryMichael J Chen
Department of Neurosurgery, Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, New York, USA
Glia 60:1660-70. 2012..the extent of Cx43 involvement in chronic pain, a weight-drop SCI was performed on transgenic mice with Cx43/Cx30 deletions...
- GJB6, of which mutations underlie Clouston syndrome, is a potential direct target gene of p63Atsushi Fujimoto
Laboratory of Genetic Skin Diseases, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
J Dermatol Sci 69:159-66. 2013..The disease is caused by mutations in GJB6 gene, which encodes a gap junction protein connexin 30 (Cx30).
- Connexin47 protein phosphorylation and stability in oligodendrocytes depend on expression of Connexin43 protein in astrocytesDennis May
Life and Medical Sciences Institute, Molecular Genetics, University of Bonn, D 53115 Bonn, Germany
J Neurosci 33:7985-96. 2013..These results further unravel the complexity of panglial networks and show that results of previous studies using astrocytic Cx43-deficient mice have to be reconsidered...
- Hearing is normal without connexin30Anne Cécile Boulay
College de France, Centre Interdisciplinaire de Recherche en Biologie CIRB Centre National de la Recherche Scientifique CNRS, Unité Mixte de Recherche UMR 7241 Institut National de la Santé et de la Recherche Médicale Inserm, U1050, 75231 Paris Cedex 05, France
J Neurosci 33:430-4. 2013Gjb2 and Gjb6, two contiguous genes respectively encoding the gap junction protein connexin26 (Cx26) and connexin 30 (Cx30) display overlapping expression in the inner ear...
- A pair of co-opted retroviral envelope syncytin genes is required for formation of the two-layered murine placental syncytiotrophoblastAnne Dupressoir
Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8122, and Unité de Génomique Fonctionnelle, Institut Gustave Roussy, 94805 Villejuif, France
Proc Natl Acad Sci U S A 108:E1164-73. 2011..Microarray analyses identified up-regulation of the connexin 30 gene in mutant placentae, with the protein localized at the fetomaternal interface, suggesting gap junction-..
- SMAD 8 binding to mice Msx1 basal promoter is required for transcriptional activationRenata Binato
Laboratorio de Biologia Molecular Maury Miranda, Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
Biochem J 393:141-50. 2006..Our results suggest that BMP2/BMP4 signalling through SMAD 8 is required for transcriptional activation of the mouse Msx1 gene...
- Milk secretion and ejection are impaired in the mammary gland of mice harboring a Cx43 mutant while expression and localization of tight and adherens junction proteins remain unchangedIsabelle Plante
Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada
Biol Reprod 82:837-47. 2010..Surprisingly, the levels and/or localization of Cx26 (Gjb2), Cx30 (Gjb6), Cx32 (Gjb1), E-cadherin, P-cadherin, beta-catenin, claudin-1, and occludin were all unaffected by the ..
- Connexin-deficiency affects expression levels of glial glutamate transporters within the cerebrumTina Unger
Institute of Anatomy, University of Leipzig, Medical Faculty, Liebigstr 13, 04103 Leipzig, Germany
Neurosci Lett 506:12-6. 2012..transporters, we have now assessed their expression levels in brains of conditional Cx43 knockout mice, total Cx30 knockouts, as well as Cx43/Cx30 double knockouts...
- Plasticity of astroglial networks in olfactory glomeruliLisa Roux
College de France, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7241 Institut National de la Santé et de la Recherche Médicale U1050, 75231 Paris Cedex 05, France
Proc Natl Acad Sci U S A 108:18442-6. 2011..of glomerular astrocytes to the glomerulus center and the enriched expression of two astroglial connexins (Cx43 and Cx30) within the glomeruli...
- Gap junctions mediate intercellular spread of sodium between hippocampal astrocytes in situJulia Langer
Institute of Neurobiology, Heinrich Heine University Duesseldorf, Universitatsstrasse 1, Duesseldorf, Germany
Glia 60:239-52. 2012..was disturbed on pharmacological inhibition of gap junctions, reduced in animals at P4 and virtually omitted in Cx30/Cx43 double-deficient mice...
- Human connexin 30 (GJB6), a candidate gene for nonsyndromic hearing loss: molecular cloning, tissue-specific expression, and assignment to chromosome 13q12P M Kelley
Center for Hereditary Communication Disorders, Boys Town National Research Hospital, Omaha, Nebraska 68131, USA
Genomics 62:172-6. 1999..Another gap junction gene, connexin 30 (HGMW-approved symbol GJB6), is found to lie on the same PAC clone that hybridizes to chromosome 13q12...
- Functional significance of gap junctional coupling in preimplantation developmentF D Houghton
Department of Physiology, Dental Sciences Building, The University of Western Ontario, London, Ontario, Canada N6A 5C1
Biol Reprod 66:1403-12. 2002..from reverse transcription-polymerase chain reaction analysis that the genes encoding 3 additional connexins (connexin 30 or beta6, connexin 36 or alpha9, and connexin 57 or alpha10) are also transcribed in preimplantation mouse ..
- Altered connexin expression and wound healing in the epidermis of connexin-deficient miceMarkus Kretz
Institut fur Genetik, Abteilung Molekulargenetik Römerstrasse 164, 53117 Bonn, Germany
J Cell Sci 116:3443-52. 2003..These results suggest that downregulation of connexin43 appears to be a prerequisite for the coordinated proliferation and mobilization of keratinocytes during wound healing...
- Connexin30-deficient mice show increased emotionality and decreased rearing activity in the open-field along with neurochemical changesE Dere
Institute of Physiological Psychology, Center for Biological and Medical Research, Heinrich Heine University of Dusseldorf, Germany
Eur J Neurosci 18:629-38. 2003..Thus, we have tested groups of Cx30-/-, Cx30+/-, and Cx30+/+ mice in the open-field, an object exploration task, in the graded anxiety test and on the ..
- An update on connexin genes and their nomenclature in mouse and manGoran Sohl
Institut fur Genetik, Universitat Bonn, Germany
Cell Commun Adhes 10:173-80. 2003..Furthermore, this short review contains an update on phenotypic correlations between connexin deficient mice and patients bearing mutations in their orthologous connexin genes...
- An expression atlas of connexin genes in the mouseAnnalisa Buniello
Telethon Institute of Genetics and Medicine, Via P Castellino 111, 80131 Naples, Italy
Genomics 83:812-20. 2004....
- The novel mouse connexin39 gene is expressed in developing striated muscle fibersJulia von Maltzahn
Institut fur Genetik, Abteilung Molekulargenetik, Universitat Bonn, Römerstr 164, 53117 Bonn, Germany
J Cell Sci 117:5381-92. 2004..As expression of no other known connexin could be verified in these cells, intercellular dye transfer might result from functional expression of Cx39 in developing striated muscle fibers...
- Connexin30 in rodent, cat and human brain: selective expression in gray matter astrocytes, co-localization with connexin43 at gap junctions and late developmental appearanceJ I Nagy
Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
Neuroscience 88:447-68. 1999..Taken together, these results suggest that astrocytic connexin30 expression at both regional and cellular levels is subject to regulation in adult brain as well as during brain development...
- Strain background effects and genetic modifiers of hearing in miceKenneth R Johnson
The Jackson Laboratory, Bar Harbor, ME 04609, USA
Brain Res 1091:79-88. 2006..Because modifier genes and digenic inheritance are not always distinguishable, we also include in this review several examples of digenic inheritance of hearing loss that have been reported in both mice and humans...
- Nature of Cx30-containing channels in the adult mouse mammary glandDarren Locke
Department of Pharmacology and Physiology, New Jersey Medical School, UMDNJ, Newark, NJ 07103, USA
Cell Tissue Res 328:97-107. 2007..Additionally, Cx30 is abundant in late-pregnant and early lactating gland epithelium...
- The connexin31 F137L mutant mouse as a model for the human skin disease erythrokeratodermia variabilis (EKV)Marc Schnichels
Institut fur Genetik, Abteilung Molekulargenetik, Universitat Bonn, Bonn 53117, Germany
Hum Mol Genet 16:1216-24. 2007..So far, several mutations in the Cx31 or Cx30.3 gene have been reported to cause EKV in humans...
- Expression of connexins in embryonic mouse neocortical developmentCima Cina
Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
J Comp Neurol 504:298-313. 2007..family of gap junction proteins, Cx26, Cx36, Cx37, Cx43, and Cx45 were expressed in the developing cortex of mice, Cx30 and Cx32 were absent, while Cx40 was expressed at a very low level...
- Analysis of connexin subunits required for the survival of vestibular hair cellsYan Qu
Department of Otolaryngology, Emory University School of Medicine, Atlanta, Georgia 30322 3030, USA
J Comp Neurol 504:499-507. 2007..The most commonly found human Cx mutations are either Cx26 or Cx30 deletions...
- A central role of connexin 43 in hypoxic preconditioningJane H C Lin
Department of Pathology, New York Medical College, Valhalla, New York 10595, USA
J Neurosci 28:681-95. 2008..Thus, adaptive modulation of Cx43 can offset environmental stress by adenosine-mediated elevation of cellular resistance...
- Neurons control the expression of connexin 30 and connexin 43 in mouse cortical astrocytesAnnette Koulakoff
INSERM, U840, College de France, 11 place Marcelin Berthelot, Paris, France
Glia 56:1299-311. 2008..The two main connexins, Cx30 and Cx43, that form these junctions in astrocytes of adult brain display different developmental and regional ..
- Gap junction mediated intercellular metabolite transfer in the cochlea is compromised in connexin30 null miceQing Chang
Department of Otolaryngology, Emory University School of Medicine, Atlanta, GA, USA
PLoS ONE 3:e4088. 2008Connexin26 (Cx26) and connexin30 (Cx30) are two major protein subunits that co-assemble to form gap junctions (GJs) in the cochlea. Mutations in either one of them are the major cause of non-syndromic prelingual deafness in humans...
- Connexin 30 deficiency impairs renal tubular ATP release and pressure natriuresisArnold Sipos
Department of Physiology and Biophysics and Department of Medicine, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA 90033, USA
J Am Soc Nephrol 20:1724-32. 2009..Several connexin (Cx) isoforms form mechanosensitive, ATP-permeable hemichannels. We localized Cx30 to the nonjunctional apical membrane of cells in the distal nephron and tested whether Cx30 participates in ..
- Deletion of astrocyte connexins 43 and 30 leads to a dysmyelinating phenotype and hippocampal CA1 vacuolationSarah E Lutz
Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Neurosci 29:7743-52. 2009Astrocytes are coupled via gap junctions (GJs) comprising connexin 43 (Cx43) (Gja1) and Cx30 (Gjb6), which facilitate intercellular exchange of ions. Astrocyte connexins also form heterotypic GJs with oligodendrocytic somata and lamellae...
- Connexin 30 is expressed in the mouse sino-atrial node and modulates heart rateDaniel Gros
Institut de Biologie du Developpement de Marseille Luminy, Universite de la Mediterranee, Marseille, France
Cardiovasc Res 85:45-55. 2010This study aimed at characterizing expression and the functional role of the Gjb6 gene, encoding for connexin 30 (Cx30) protein, in the adult mouse heart.
- Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexinsFrancisco J del Castillo
Unite de Genetique et Physiologie de l Audition, Institut Pasteur, Paris, France
Hum Mol Genet 19:262-75. 2010..Sequence accession numbers. GenBank: Human CNST cDNA, NM_152609; mouse Cnst cDNA, NM_146105...
- Molecular cloning and functional expression of mouse connexin-30,a gap junction gene highly expressed in adult brain and skinE Dahl
Institut fur Genetik, Abteilung Molekulargenetik, Universitat Bonn, 53117 Bonn, Federal Republic of Germany
J Biol Chem 271:17903-10. 1996..This suggests that the polarity of voltage gating and the cationic selectivity of connexin-30 are similar to those of its closest homologue, connexin-26...
- The human deafness-associated connexin 30 T5M mutation causes mild hearing loss and reduces biochemical coupling among cochlear non-sensory cells in knock-in miceMelanie Schütz
Institut fuer Genetik, Rheinische Friedrich Wilhelms Universitaet Bonn, Roemerstrasse 164, D 53117 Bonn, Germany
Hum Mol Genet 19:4759-73. 2010Mutations in the GJB2 and GJB6 genes, respectively, coding for connexin26 (Cx26) and connexin30 (Cx30) proteins, are the most common cause for prelingual non-syndromic deafness in humans...
- Diminished paracrine regulation of the epithelial Na+ channel by purinergic signaling in mice lacking connexin 30Elena Mironova
Department of Physiology, University of Texas Health Science Center, San Antonia, Texas 78229 3900, USA
J Biol Chem 286:1054-60. 2011We tested whether ATP release through Connexin 30 (Cx30) is part of a local purinergic regulatory system intrinsic to the aldosterone-sensitive distal nephron (ASDN) important for proper control of sodium excretion; if changes in sodium ..
- Dysfunction of astrocyte connexins 30 and 43 in dorsal lateral prefrontal cortex of suicide completersCarl Ernst
McGill Group for Suicide Studies, McGill University, Montreal, Quebec, Canada
Biol Psychiatry 70:312-9. 2011..Although it is known that particular neurobiological processes underlie suicidal ideation and behavior, there still remains limited knowledge about the specific factors involved...
- Epithelial Na channel (ENaC) polymorphisms in hyptertentionJames Stockand; Fiscal Year: 2007..Preliminary results support the feasibility of this investigation and suggest that this line of inquiry will yield significant and novel findings. [unreadable] [unreadable]..
- Stoichiometry and modular retrieval of ENaCJames Stockand; Fiscal Year: 2009..This research will provide critical insight about the molecualr architecture of ENaC and regulation of this important channel. ..