Gene Symbol: Gpi1
Description: glucose phosphate isomerase 1
Alias: Amf, Gpi, Gpi-1, Gpi-1r, Gpi-1s, Gpi-1t, Gpi1-r, Gpi1-s, Gpi1-t, Gpi1s, NK/GPI, Nlk, Org, Pgi, Phi, glucose-6-phosphate isomerase, autocrine motility factor, glucose phosphate isomerase 1 complex, glucose phosphate isomerase 1, regulatory, glucose phosphate isomerase 1, structural, glucose phosphate isomerase 1, temporal, maturation factor, neuroleukin, phosphoglucose isomerase, phosphohexose isomerase
Species: mouse

Top Publications

  1. ncbi Genetic mapping of a new homeobox gene to mouse chromosome 7
    K R Johnson
    Jackson Laboratory, Bar Harbor, Maine 04609
    Genomics 14:1107-9. 1992
  2. pmc Chromosomal assignment of two endogenous ecotropic murine leukemia virus proviruses of the AKR/J mouse strain
    B A Taylor
    J Virol 56:172-5. 1985
  3. ncbi Mitochondrial malate dehydrogenase and malic enzyme: Mendelian inherited electrophoretic variants in the mouse
    T B Shows
    Biochem Genet 4:707-18. 1970
  4. pmc Formation of IL-7Ralphahigh and IL-7Ralphalow CD8 T cells during infection is regulated by the opposing functions of GABPalpha and Gfi-1
    Anmol Chandele
    Department of Immunobiology, Yale Medical School, New Haven, CT 06511, USA
    J Immunol 180:5309-19. 2008
  5. ncbi Genetic characterization of important mouse strains used in cancer research
    H H Krog
    Hereditas 87:201-4. 1977
  6. ncbi Genetic regulation of glucose phosphate isomerase in mouse oocytes
    A C Peterson
    Nature 276:267-9. 1978
  7. ncbi Conservation of autosomal gene synteny groups in mouse and man
    P A Lalley
    Nature 274:160-3. 1978
  8. pmc Genetic variation at a locus (TAM-1) for submaxillary gland protease in the mouse and its location on chromosome No. 7
    L C Skow
    Genetics 90:713-24. 1978
  9. ncbi Characterization of murine carcinoembryonic antigen gene family members
    F Rudert
    Institut fur Immunbiologie, Universitat Freiburg, FRG
    Mamm Genome 3:262-73. 1992
  10. ncbi Fat (fat) and tubby (tub): two autosomal recessive mutations causing obesity syndromes in the mouse
    D L Coleman
    Jackson Laboratory, Bar Harbor, Maine 04609
    J Hered 81:424-7. 1990

Scientific Experts

  • Hiroshi Kondoh
  • Jo Peters
  • Nobutada Tanaka
  • Robert A White
  • J Martin Collinson
  • Walter Pretsch
  • Arayo Haga
  • Hady Felfly
  • N A Jenkins
  • N G Copeland
  • Jennifer A Walker
  • Avraham Raz
  • Patricia Benveniste
  • Marie Trudel
  • Tatsuyoshi Funasaka
  • Anmol Chandele
  • A Repiso
  • Natasha Szuber
  • A Kelly
  • Carla M Cuda
  • Noriko Naba
  • Soichi Tsutsumi
  • J T Graham Solomons
  • Simon N Archer
  • Hisamitsu Nagase
  • J D West
  • Caryn Y Ito
  • C A Kozak
  • Isao Matsumoto
  • D J Gilbert
  • Ekaterini Kotsopoulou
  • Marion Espeli
  • Andrew M Hall
  • Lars Nitschke
  • Paul A Lyons
  • Robert N Barker
  • Kenneth G C Smith
  • Salima Janmohamed
  • Deborah Hyam
  • R Bauchwitz
  • Catherine Frelin
  • Mary Barbara
  • Robert Herrington
  • Norman N Iscove
  • Joan L Buss
  • R Andres
  • J M Urena
  • Nikhil S Joshi
  • Prem Ponka
  • F Climent
  • William E Paul
  • Warren J Leonard
  • Shan Soe-Lin
  • G B Downes
  • Susan M Kaech
  • Jinfang Zhu
  • Suigui Wan
  • Laurence Morel
  • Byron P Croker
  • P W Lane
  • Eric S Sobel
  • I Ben-Porath
  • K Kalman
  • Romeo Caffe
  • Theo van Veen
  • N Krishnamurthy
  • Hilary Muirhead
  • Tatsuo Shimura
  • John Chirgwin
  • Poonam Ahuja
  • Takashi Yanagawa
  • Yoshio Kusakabe
  • Michael K Swan
  • Russell G Foster
  • Sandra Krings
  • R T Bronson
  • Hiroyuki Kuwano
  • Ella M Zimmerly
  • Katsura Shiraiwa
  • Malcolm von Schantz
  • Kazuo T Nakamura
  • Christopher Davies
  • Catherine Mikol
  • Suzanne Burns
  • P Faik
  • Carol Y J Li
  • John E Dick
  • William L Stanford
  • Alan Bernstein
  • David M Lee

Detail Information

Publications105 found, 100 shown here

  1. ncbi Genetic mapping of a new homeobox gene to mouse chromosome 7
    K R Johnson
    Jackson Laboratory, Bar Harbor, Maine 04609
    Genomics 14:1107-9. 1992
    ..No recombination was observed between Dbx and Odc-rs6, indicating that Dbx lies approximately 25 cM distal to the Chr 7 centromere in a region that has conserved linkage relationships with regions of human Chrs 11 and 19...
  2. pmc Chromosomal assignment of two endogenous ecotropic murine leukemia virus proviruses of the AKR/J mouse strain
    B A Taylor
    J Virol 56:172-5. 1985
    ..Akv-3 is the second ecotropic murine leukemia virus provirus to be mapped near the agouti locus. The results are discussed in relation to possible nonrandomness of viral integration...
  3. ncbi Mitochondrial malate dehydrogenase and malic enzyme: Mendelian inherited electrophoretic variants in the mouse
    T B Shows
    Biochem Genet 4:707-18. 1970
  4. pmc Formation of IL-7Ralphahigh and IL-7Ralphalow CD8 T cells during infection is regulated by the opposing functions of GABPalpha and Gfi-1
    Anmol Chandele
    Department of Immunobiology, Yale Medical School, New Haven, CT 06511, USA
    J Immunol 180:5309-19. 2008
  5. ncbi Genetic characterization of important mouse strains used in cancer research
    H H Krog
    Hereditas 87:201-4. 1977
  6. ncbi Genetic regulation of glucose phosphate isomerase in mouse oocytes
    A C Peterson
    Nature 276:267-9. 1978
  7. ncbi Conservation of autosomal gene synteny groups in mouse and man
    P A Lalley
    Nature 274:160-3. 1978
  8. pmc Genetic variation at a locus (TAM-1) for submaxillary gland protease in the mouse and its location on chromosome No. 7
    L C Skow
    Genetics 90:713-24. 1978
    ..strains and B6AF1 X B6 and B6D2F1 X B6 backcrosses established linkage of Tam-1 to glucose phosphate isomerase (Gpi-1), pink-eyed dilution [p] and beta-hemoglobin (Hbb) on chromosome 7. The gene order is Gpi-1--Tam-1--p--HBB...
  9. ncbi Characterization of murine carcinoembryonic antigen gene family members
    F Rudert
    Institut fur Immunbiologie, Universitat Freiburg, FRG
    Mamm Genome 3:262-73. 1992
    ..The more distantly related Cea-5 seems to be ubiquitously expressed. The putative promoter region of Cea-2 lacks typical TATA- or CAAT-boxes, but contains other conserved motifs that could play a role in the initiation of transcription...
  10. ncbi Fat (fat) and tubby (tub): two autosomal recessive mutations causing obesity syndromes in the mouse
    D L Coleman
    Jackson Laboratory, Bar Harbor, Maine 04609
    J Hered 81:424-7. 1990
  11. ncbi The mouse Cebp gene encoding a DNA-binding protein is polymorphic and is located on chromosome 7
    K G Xanthopoulos
    Rockefeller University, New York, NY 10021
    Cytogenet Cell Genet 50:174-5. 1989
  12. ncbi Glucosephosphate isomerase (GPI-1) expression in mouse ova: cis regulation of monomer realization
    A Peterson
    Biochem Genet 23:827-46. 1985
    A survey of the glucosephosphate isomerase (GPI-1) activity expressed in mature mouse ova has revealed multiple interstrain differences. Genetic variation at a site either linked to (less than 1...
  13. pmc DNA sequence polymorphism in an androgen-regulated gene is associated with alteration in the encoded RNAs
    R W Elliott
    Proc Natl Acad Sci U S A 80:501-4. 1983
    ..908 structural gene, revealed by Southern blotting of HindIII-generated DNA fragments, was found to map near the Gpi-1 and Tam-1 loci on chromosome 7. The 908 structural gene has been termed RP2...
  14. pmc Chromosomal mapping of murine c-fes and c-src genes
    C Blatt
    Mol Cell Biol 4:978-81. 1984
    ..The c-fes gene was mapped to the proximal portion of chromosome 7, very close to the Gpi-1 locus, whereas c-src was linked to the Psp locus on the distal half of chromosome 2.
  15. ncbi Reduced pigmentation (rp), a new coat colour gene with effects on kidney lysosomal glycosidases in the mouse
    S Gibb
    Genet Res 37:95-103. 1981
  16. ncbi GPI expression in female germ cells of the mouse
    A McLaren
    Genet Res 37:303-9. 1981
  17. ncbi Genetic variation for prolidase (PEP-4) in the mouse maps near the gene for glucosephosphate isomerase (GPI-1) on chromosome 7
    L C Skow
    Biochem Genet 19:695-700. 1981
    ..forms are expressed codominantly and that Pep-4 is located between the genes for glucosephosphate isomerase (Gpi-1) and pink-eyed dilution (p) on chromosome 7...
  18. ncbi A single B1 subunit mapped to mouse chromosome 7 may be a common component of Na channel isoforms from brain, skeletal muscle and heart
    J Tong
    Dept of Physiology, Johns Hopkins University School of Medicine
    Biochem Biophys Res Commun 195:679-85. 1993
    ..A mutation in a single beta 1 subunit forming functional complexes with multiple Na channel isoforms could underlie these deficits...
  19. ncbi Genomic organization, nucleotide sequence, biophysical properties, and localization of the voltage-gated K+ channel gene KCNA4/Kv1.4 to mouse chromosome 2/human 11p14 and mapping of KCNC1/Kv3.1 to mouse 7/human 11p14.3-p15.2 and KCNA1/Kv1.1 to human 12p13
    R S Wymore
    Department of Physiology, University of California, Irvine 92717
    Genomics 20:191-202. 1994
    ..1, lies approximately 1.8 cM from the Myod-1 gene on mouse chromosome 7, and in situ hybridization localizes KCNC1/hKv3.1 to the homologous region on human chromosome 11p14.3-p15.2. A third gene, KCNA1/hKv1.1, was mapped to human 12p13...
  20. ncbi A genetically defined animal model of anembryonic pregnancy
    J D West
    Department of Obstetrics and Gynaecology, University of Edinburgh, UK
    Hum Reprod 8:1316-23. 1993
    ..mouse conceptuses, homozygous for a defect in the gene encoding the glycolytic enzyme, glucose phosphate isomerase (GPI) died in utero by 9 1/2 days post coitum...
  21. ncbi Sequence characterization of alleles Gpi1-Sa and Gpi1-Sb at the glucose phosphate isomerase structural locus
    S R Pearce
    Wellcome Research Laboratory for Molecular Genetics, Division of Biochemistry and Molecular Biology, UMDS, Guy s Hospital, London, UK
    Mamm Genome 6:537-9. 1995
    The sequences of alleles Gpi1-sa and Gpi1-sb at the glucose phosphate isomerase structural locus have been determined from cDNA of the mouse inbred strains 101/H Gpi1-sa and C3H/HeH Gpi1-sb by RT PCR and direct sequencing of the amplified ..
  22. ncbi Genetic evidence that glycolysis is necessary for gastrulation in the mouse
    A Kelly
    Department of Obstetrics and Gynaecology, University of Edinburgh, Scotland, UK
    Dev Dyn 207:300-8. 1996
    Mouse embryos homozygous for the Gpi1-sa-m1H null allele (abbreviated to m) of glucose phosphate isomerase (GPI) die early in development...
  23. ncbi Chromosome mapping of the mouse Akt2 gene and Akt2 pseudogene
    D A Altomare
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cytogenet Cell Genet 74:248-51. 1996
    ..The Akt2 pseudogene was mapped to proximal MMU11 by both multilocus mapping and fluorescence in situ hybridization...
  24. ncbi Chromosomal mapping of Tmp (Emp1), Xmp (Emp2), and Ymp (Emp3), genes encoding membrane proteins related to Pmp22
    I Ben-Porath
    Department of Genetics, Hebrew University, Jerusalem, Israel
    Genomics 49:443-7. 1998
    ..These data suggest that this family of membrane glycoproteins evolved as a result of chromosomal duplications...
  25. ncbi Developmentally distinct effects on human epsilon-, gamma- and delta-globin levels caused by the absence or altered position of the human beta-globin gene in YAC transgenic mice
    R Bauchwitz
    Columbia University, Department of Genetics and Development, 701 West 168th Street, New York, NY 10032, USA
    Hum Mol Genet 9:561-74. 2000
    ..The relationship of these measurements of transgenic globin expression to a possible binary model of globin LCR action and to mimicry from red blood cell loss due to transgenic globin imbalances are discussed...
  26. ncbi Survival and normal function of glycolysis-deficient mouse oocytes
    A Kelly
    Genes and Development Group, Department of Reproductive and Developmental Sciences, University of Edinburgh, Hugh Robson Building, George Square, UK
    Reproduction 124:469-73. 2002
    Mouse embryos homozygous for a null allele of Gpi1 which encodes the glycolytic enzyme glucose phosphate isomerase fail to complete gastrulation and die at about embryonic day 7...
  27. ncbi Absence of phosphoglucose isomerase-1 in retinal photoreceptor, pigment epithelium and Muller cells
    Simon N Archer
    School of Biomedical and Molecular Sciences, University of Surrey, Guildford GU2 7XH, UK
    Eur J Neurosci 19:2923-30. 2004
    ..Extracellularly, Gpi1 may act as a cytokine, independently described as neuroleukin and autocrine motility factor. Retinal Gpi1 expression was investigated by Northern and Western blot analysis and immunohistochemistry...
  28. ncbi Autocrine motility factor signaling enhances pancreatic cancer metastasis
    Soichi Tsutsumi
    Department of General Surgical Science Surgery I, Gunma University Graduate School of Medicine, Maebashi, Japan
    Clin Cancer Res 10:7775-84. 2004
    b>Autocrine motility factor (AMF)/phosphoglucose isomerase (PGI) is a ubiquitous cytosolic enzyme that plays a key role in glycolysis...
  29. ncbi Glycolytic enzymes can modulate cellular life span
    Hiroshi Kondoh
    Wolfson Institute for Biomedical Research, University College London, London Research Institute, London, United Kingdom
    Cancer Res 65:177-85. 2005
    ..Because wild-type p53 down-regulates PGM, mutation of p53 can facilitate immortalization via effects on PGM levels and glycolysis...
  30. ncbi Murine lupus susceptibility locus Sle1a controls regulatory T cell number and function through multiple mechanisms
    Carla M Cuda
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610, USA
    J Immunol 179:7439-47. 2007
    ..Overall, these results show that Sle1a controls both Treg number and function by multiple mechanisms, directly on the Tregs themselves and indirectly through the response of effector T cells and the regulatory role of dendritic cells...
  31. doi Successful correction of murine sickle cell disease with reduced stem cell requirements reinforced by fractionated marrow infusions
    Hady Felfly
    Institut de Recherches Cliniques de Montreal, Molecular Genetics and Development, Faculte de Medecine de l Universite de Montreal, 110 ouest avenue des Pins, Montreal, QC, Canada
    Br J Haematol 148:646-58. 2010
  32. doi Intermediate-term hematopoietic stem cells with extended but time-limited reconstitution potential
    Patricia Benveniste
    Ontario Cancer Institute, Toronto, ON M5G 2M9, Canada
    Cell Stem Cell 6:48-58. 2010
  33. doi Increased red cell turnover in a line of CD22-deficient mice is caused by Gpi1c: a model for hereditary haemolytic anaemia
    Jennifer A Walker
    Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
    Eur J Immunol 42:3212-22. 2012
    ..mice is red cell intrinsic and appears to be the consequence of a defective allele of glucose phosphate isomerase, Gpi1(c)...
  34. ncbi Assignment of the genes for thymidine kinase and galactokinase to Mus musculus chromosome 11 and the preferential segregation of this chromosome in Chinese hamster/mouse somatic cell hybrids
    C A Kozak
    Somatic Cell Genet 3:121-33. 1977
  35. ncbi Gene linkage analysis in the mouse by somatic cell hybridization: assignment of adenine phosphoribosyltransferase to chromosome 8 and alpha-galactosidase to the X chromosome
    C Kozak
    Somatic Cell Genet 1:371-82. 1975
    ..All other isozymes examined segregated independently of one another...
  36. ncbi Linear dose-response relationship of erythrocyte enzyme-activity mutations in offspring of ethylnitrosourea-treated mice
    D J Charles
    Mutat Res 176:81-91. 1987
    ..The recovered mouse mutants might be used as animal models to study corresponding genetic diseases in humans...
  37. ncbi Characterization and chromosomal location of endogenous mouse mammary tumor virus loci in GR, NFS, and DBA mice
    J I MacInnes
    Virology 132:12-25. 1984
  38. ncbi Xylose dehydrogenase-1, a new gene on mouse chromosome 7
    M F Newton
    Biochem Genet 20:733-45. 1982
    ..Two of these determine proteins differing in electrophoretic mobility and the third is a "null." This easily scored variation may prove useful both for gene mapping and in population genetics...
  39. pmc Application of the ovarian teratoma mapping method in the mouse
    J T Eppig
    Genetics 103:797-812. 1983
    ..Centromere-gene recombination was measured at 11.3 +/- 1.2% for the centromere of chromosome 7 - Gpi-1 interval and 15.8 +/- 2.4% for the centromere of chromosome 14 - Np-1 interval using the ovarian teratoma method...
  40. ncbi Mouse cartilage matrix deficiency (cmd) caused by a 7 bp deletion in the aggrecan gene
    H Watanabe
    Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892
    Nat Genet 7:154-7. 1994
    ..DNA sequencing of the aggrecan gene identified a 7 bp deletion in exon 5 resulting in a severely truncated molecule. The finding of an aggrecan mutation in the cmd mouse confirms the critical role of aggrecan in cartilage formation...
  41. ncbi Genetic predisposition to pre-B lymphomas in SL/Kh strain mice
    Y Yamada
    Department of Pathology, Faculty of Medicine, Kyoto University, Japan
    Cancer Res 54:403-7. 1994
    ..One, encoded by a 27-kilobase EcoRI fragment, was closely linked to Gpi-1a on chromosome 7 and its expression seemed to be a prerequisite for the occurrence of all types of hemopoietic ..
  42. ncbi Identification of a new family of Pbx-related homeobox genes
    T Nakamura
    ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    Oncogene 13:2235-42. 1996
    ..The identification of two additional Meis genes identifies a new family of potential Hox cofactors as well as two new potential disease genes...
  43. ncbi Hematopoietic stem cell and progenitor defects in Sca-1/Ly-6A-null mice
    Caryn Y Ito
    Programme in Cancer Blood, Hospital for Sick Children, Toronto, ON, Canada
    Blood 101:517-23. 2003
    ..Thus, our studies conclusively demonstrate that Sca-1, in addition to being a marker of HSCs, regulates the developmental program of HSCs and specific progenitor populations...
  44. ncbi Crystallization and preliminary X-ray crystallographic studies of mouse autocrine motility factor
    Noriko Naba
    School of Pharmaceutical Sciences, Showa University, Tokyo 142 8555, Japan
    Acta Crystallogr D Biol Crystallogr 60:2084-6. 2004
    Mouse autocrine motility factor (mAMF), a tumour-secreted cytokine that stimulates cell migration in vitro and metastasis in vivo, has been crystallized by the hanging-drop vapour-diffusion method...
  45. ncbi Chromosomal localization of uroplakin genes of cattle and mice
    A M Ryan
    Department of Veterinary Pathobiology, Texas A and M University, College Station 77843
    Mamm Genome 4:656-61. 1993
    ..Our results also suggest likely positions for two human uroplakin genes and should facilitate further analysis of their possible involvement in disease...
  46. ncbi Biochemical genetics of a new glucosephosphate isomerase allele (Gpi-1c) from wild mice
    R A Padua
    Biochem Genet 16:127-43. 1978
    We have found a new allele at the structural locus for glucosephosphate isomerase (called Gpi-1c) in a population of wild mice...
  47. pmc Assignment of genes to regions of mouse chromosomes
    E M Eicher
    Proc Natl Acad Sci U S A 75:946-50. 1978
  48. ncbi Genetic regulation of coumarin hydroxylase activity in mice. Evidence for single locus control on chromosome
    A W Wood
    J Biol Chem 254:5647-51. 1979
  49. ncbi Acute and late disease induced by murine coronavirus, strain JHM, in a series of recombinant inbred strains between BALB/cHeA and STS/A mice
    S Kyuwa
    Department of Animal Pathology, University of Tokyo, Japan
    Microb Pathog 12:95-104. 1992
    ..These results may suggest that JHMV-induced late disease is also under multifactorial control. The pathogenesis of JHMV infection is discussed...
  50. pmc Tissue restricted expression and chromosomal localization of the YB-1 gene encoding a 42 kD nuclear CCAAT binding protein
    D D Spitkovsky
    Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, Heidelberg, FRG
    Nucleic Acids Res 20:797-803. 1992
    ..Finally, we have identified four YB-1 related loci in the mouse genome and have mapped these loci to four different mouse chromosomes by interspecific backcross analysis...
  51. ncbi Murine chromosomal location of four hepatocyte-enriched transcription factors: HNF-3 alpha, HNF-3 beta, HNF-3 gamma, and HNF-4
    K B Avraham
    Mammalian Genetics Laboratory, National Cancer Institute Frederick Cancer Research and Development Center, Maryland 21702
    Genomics 13:264-8. 1992
  52. ncbi Genetic and age related models of neurodegeneration in mice: dystrophic axons
    R T Bronson
    Jackson Laboratory, Bar Harbor, ME 04609
    J Neurogenet 8:71-83. 1992
    ..The mutant models of neuroaxonal dystrophy may prove useful in studies of the pathophysiology of DA in general and of specific inherited diseases of man, such as infantile neuroaxonal dystrophy and Hallervordin-Spatz disease...
  53. pmc Immune responses in newly developed short-lived SAM mice. IV. Chromosomal location of a gene controlling defective helper T-cell activity
    K Hanada
    Department of Senescence Biology, Kyoto University, Japan
    Immunology 74:160-4. 1991
    ..Low responders in the F2 generation showed a significantly higher incidence of SAM-P/1 genotype at the Gpi-1 as well as c locus on chromosome 7 (Chr.7)...
  54. ncbi Segregation of genes from donor strain during the production of recombinant congenic strains
    L F van Zutphen
    Department of Laboratory Animal Science, Faculty of Veterinary Medicine, University of Utrecht, The Netherlands
    Lab Anim 25:193-7. 1991
    ..Four marker genes (Pep-3; Pgm-1; Gpi-1 and Es-3) located at 4 different chromosomes were selected and the allelic distribution was tested after 3-4 and ..
  55. ncbi Characterization and chromosomal mapping of a cDNA encoding tryptophan hydroxylase from a mouse mastocytoma cell line
    J Stoll
    Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892
    Genomics 7:88-96. 1990
    ..Because TPH has been mapped to human chromosome 11, this assignment further defines regions of homology between these mouse and human chromosomes...
  56. ncbi Glucose phosphate isomerase enzyme-activity mutants in Mus musculus: genetical and biochemical characterization
    W Pretsch
    GSF Institut für Säugetiergenetik, Ingolstädter Landstr, Neuherberg, Federal Republic of Germany
    Biochem Genet 28:97-110. 1990
    Two glucose-6-phosphate isomerase (GPI) mutants with approximately 60% residual activity in blood compared to wild type have been independently detected in offspring derived from 1-ethyl-1-nitrosourea-treated male mice...
  57. ncbi Hydrocephalus with hop gait (hyh): a new mutation on chromosome 7 in the mouse
    R T Bronson
    Jackson Laboratory, Bar Harbor, ME 04609
    Brain Res Dev Brain Res 54:131-6. 1990
    ..It has been mapped to the proximal end of Chromosome 7 close to the Gpi-1 locus...
  58. ncbi Analysis of mutations of glucose phosphate isomerase-1, Gpi-1, in the mouse
    J Peters
    M R C Radiobiology Unit, Didcot, Oxon
    Prog Clin Biol Res 340:125-32. 1990
  59. ncbi Chromosomal and regional localization of the genes for UMPH2, APRT, PEPD, PEPS, PSP, and PGP in mink: comparison with man and mouse
    S D Pack
    Institute of Cytology and Genetics, Academy of Sciences of the USSR, Siberian Department, Novosibirsk
    Cytogenet Cell Genet 50:127-31. 1989
    ..The present data is compared with that previously established for man and mouse with reference to the conservation of syntenic gene groups and G-band homoeologies of chromosomes in mammals...
  60. ncbi Genetic factors controlling structure and expression of apolipoproteins B and E in mice
    A J Lusis
    J Biol Chem 262:7594-604. 1987
    ..These results clarify the organization and regulation of the genes for apoB and apoE, and they provide information about the naturally occurring polymorphisms affecting their expression...
  61. ncbi Analysis of recombination in the centromere region of mouse chromosome 7 using ovarian teratoma and backcross methods
    J T Eppig
    Jackson Laboratory, Bar Harbor, ME 04609
    J Hered 79:425-9. 1988
    ..The recombination percentage for the centromere-Gpi-1 (glucose phosphate isomerase-1) interval was 13.4 +/- 2.6 using the ovarian teratoma mapping method...
  62. ncbi Molecular cloning and expression of neuroleukin, a neurotrophic factor for spinal and sensory neurons
    M E Gurney
    Science 234:566-74. 1986
    ..The factor was therefore named neuroleukin. Neuroleukin promotes the survival in culture of a subpopulation of embryonic spinal neurons that probably ..
  63. ncbi Gene mapping in the Chinese hamster and conservation of syntenic groups and Q-band homologies between Chinese hamster and mouse chromosomes
    H Satoh
    Cytogenet Cell Genet 39:285-91. 1985
    ..loci were confirmed: ESD, NP, and PEPB on chromosome 1, ME1 and MPI on chromosome 4, AK1 on chromosome 6, and GPI and PEPD on chromosome 9...
  64. ncbi Aldehyde reductase isozymes in the mouse: evidence for two new loci and localization of Ahr-3 on chromosome 7
    P B Mather
    Biochem Genet 23:483-96. 1985
    ..Genet. 20:1067, 1982)], hexonate dehydrogenase (AHR-2), and alcohol dehydrogenase A2 in terms of their differential substrate, coenzyme, and inhibitor specificities...
  65. ncbi Variations in the amount of glucose phosphate isomerase in lymphocytes and erythrocytes from A/J and C57BL/6J mice
    C M Warner
    Biochem Genet 23:815-25. 1985
    In a comparative study of A/J (Gpi-1a) and C57BL/6J (Gpi-1b) mice, we observed that erythrocytes of A/J mice exhibited significantly higher glucose phosphate isomerase (GPI) activity compared to erythrocytes of C57BL/6J mice on a per ..
  66. ncbi Genetic mapping of a murine leukemia virus-inducing locus of AKR mice
    W P Rowe
    Science 178:860-2. 1972
    ..appears to be the integrated genome of the virus, is designated Akv-1, and is on linkage group 1, 12 map units from Gpi-1, with gene order c-Gpi-1-Akv-1...
  67. ncbi Human times mouse hybrid cells segregating mouse chromosomes and isozymes
    J D Minna
    Nature 252:401-4. 1974
  68. ncbi Linkage of isozyyme loci in the mouse: phosphoglucomutase-2 (Pgm-2), mitochondrial NADP malate dehydrogenase (Mod-2), and dipeptidase-1 (Dip-1)
    V M Chapman
    Biochem Genet 5:101-10. 1971
  69. ncbi Binucleate and polyploid cells in the decidua of the mouse
    J D Ansell
    J Embryol Exp Morphol 31:223-7. 1974
  70. ncbi Linkage analyses using biochemical variants in mice. 3. Linkage relationships of eleven biochemical markers
    J J Hutton
    Biochem Genet 4:339-50. 1970
  71. ncbi Biochemical polymorphisms in feral and inbred mice (mus musculus)
    T H Roderick
    Biochem Genet 5:457-66. 1971
  72. ncbi Biochemical and immunological characterization of genetic variants of phosphoglucose isomerase from mouse
    D J Charles
    Biochem Genet 18:153-69. 1980
    Two electrophoretic variants of phosphoglucose isomerase (PGI) were purified from whole body extracts of DBA/2J and C57BL/6J mice by a substrate-affinity elution from an 8-(6-aminohexyl)amino-ATP-Sepharose column followed by preparative ..
  73. pmc Genetic mapping of endogenous mouse mammary tumor viruses: locus characterization, segregation, and chromosomal distribution
    V L Traina
    J Virol 40:735-44. 1981
    ..The results are consistent with the view that integration of mouse mammary tumor virus can take place at numerous sites within the genome, and once inserted, these proviruses appear to be relatively stable genetic entities...
  74. ncbi A new allele of the Gpi-1t temporal gene that regulates the expression of glucose phosphate isomerase in mouse oocytes
    J D West
    Genet Res 44:169-81. 1984
  75. ncbi Chromosome assignment of genes encoding the alpha and beta subunits of glycoprotein hormones in man and mouse
    S L Naylor
    Somatic Cell Genet 9:757-70. 1983 human CG beta cDNA segregated concordantly with the human chromosome 19 marker enzymes PEPD (peptidase D) and GPI (glucose phosphate isomerase) and a normal chromosome 19 in karyotyped hybrids...
  76. ncbi Serum gp70 production regulated by a gene on murine chromosome 7
    N Maruyama
    Immunogenetics 18:365-71. 1983
    ..This gene has been tentatively designated Sgp-2. Sgp-2 is linked with the Hbb locus on chromosome 7. The estimated frequency of recombination between Sgp-2 and Hbb in this setting is about 20%...
  77. ncbi The acute phase response of mouse liver. Genetic analysis of the major acute phase reactants
    H Baumann
    J Biol Chem 259:566-73. 1984
    ..Structural variation for serum amyloid A enabled mapping its structural gene, S alpha alpha, to chromosome 7, near Gpi-1...
  78. ncbi Lyb-8.2: A new B cell antigen defined and characterized with a monoclonal antibody
    F W Symington
    Immunogenetics 16:381-91. 1982
    ..The expression of Lyb-8.2 is controlled by a locus on chromosome 7 that is closely linked to Gpi-1 and RP-2. Added Lyb-8...
  79. ncbi Prt-4 and Prt-5: new constituents of a gene cluster on chromosome 7 coding for esterproteases in the submandibular gland of the house mouse (Mus musculus)
    J Otto
    Biochem Genet 19:431-44. 1981
    ..Prt-4 and Prt-5 proved to be different from Tam-1. From a four-point-cross, the gene order Gpi-1-(Tam-1, Prt-4, Prt-5)-c is suggested...
  80. ncbi Precise mapping of the gene for Ly-21.2 on the 7th chromosome
    J Kennard
    J Immunogenet 9:389-95. 1982
    ..The results of these 3-point cross studies show that the gene encoding Ly-21.2 maps 27 units distal to albinism...
  81. ncbi Confirmational, provisional, and/or regional assignment of 15 enzyme loci onto Chinese hamster autosomes 1, 2, and 7
    R L Stallings
    Somatic Cell Genet 7:683-98. 1981
    ..The assignments provide markers for the study of the genetic consequences of chromosomal rearrangements in Chinese hamster cell lines and support the concept of conservation of mammalian autosomal linkage groups...
  82. ncbi Mouse MHC class I-like Fc receptor encoded outside the MHC
    J J Ahouse
    Rosenstiel Center for Basic Biomedical Sciences, Brandeis University, Waltham, MA 02254 9110
    J Immunol 151:6076-88. 1993
    ..The mouse FcRn alpha-chain is similar in sequence to the class I MHC Ag, encoded on chromosome 17 in the mouse. However, we find that the mouse FcRn gene lies outside the MHC, on chromosome 7...
  83. pmc The genes encoding the glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in human, mouse, and rat
    C Szpirer
    Departement de Biologie Moleculaire, Universite Libre de Bruxelles, Rhode St Genese, Belgium
    Proc Natl Acad Sci U S A 91:11849-53. 1994
    ..Our data extend the conserved synteny established between certain human, mouse, and rat Chrs...
  84. ncbi Identification of a novel tandemly repeated sequence present in an intron of the glucose phosphate isomerase (GPI) gene in mouse and man
    P Faik
    Wellcome Research Laboratory for Molecular Genetics, UMDS, Guy s Hospital, London, United Kingdom
    Genomics 21:122-7. 1994
    Glucose phosphate isomerase (GPI, glucose 6-phosphate ketol-isomerase, EC is a housekeeping gene expressed in all tissues and organisms that utilize glycolysis and gluconeogenesis...
  85. pmc Glycogen synthase: a putative locus for diet-induced hyperglycemia
    M F Seldin
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
    J Clin Invest 94:269-76. 1994
    ..For hyperglycemia, 19 of 23 strains were concordant with the D7Mit25 marker and 20 of 23 strains with the Gpi-1 locus on proximal mouse chromosome 7...
  86. ncbi Linkage relationships between ALPL, ENO1, GPI, PGD, and TGFB1 on porcine chromosome 6
    P A Clamp
    Department of Animal Sciences, University of Illinois, Urbana Champaign
    Genomics 17:324-9. 1993
    ..loci encoding liver/bone/kidney alkaline phosphatase (ALPL), enolase 1-alpha (ENO1), glucose-phosphate isomerase (GPI), phosphogluconate dehydrogenase (PGD), and transforming growth factor beta 1 (TGFB1) in swine...
  87. ncbi Mouse selenocysteine tRNA([Ser]Sec) gene (Trsp) and its localization on chromosome 7
    T Ohama
    Laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    Genomics 19:595-6. 1994
  88. ncbi Genetic mapping of three GABAA receptor-subunit genes in the mouse
    M Danciger
    Jules Stein Eye Institute, UCLA School of Medicine
    Genomics 16:361-5. 1993
    ..The Gabrb-1, Gabra-2 pair of genes on Chr 5 maps near the mouse "circling mutation" pi (pirouette)...
  89. ncbi Mouse chromosomal location of the CCAAT/enhancer binding proteins C/EBP beta (Cebpb), C/EBP delta (Cebpd), and CRP1 (Cebpe)
    N A Jenkins
    ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Maryland 21702 1201, USA
    Genomics 28:333-6. 1995
    ..Here, we show that Cebpb maps to mouse chromosome 2, Cebpd to chromosome 16, and Cebpe to chromosome 14. The assignment of Cebpd to chromosome 16 identifies a new region of homology between mouse chromosome 16 and human chromosome 8...
  90. ncbi Cardiac and skeletal muscle troponin I isoforms are encoded by a dispersed gene family on mouse chromosomes 1 and 7
    J L Guenet
    Institut Pasteur de Paris, Unite de Genetique des Mammiferes, Paris, France
    Mamm Genome 7:13-5. 1996
    ..The cardiac troponin I locus (Tnni3) also mapped to Chr 7, approximately 5-10 cM from the centromere and unlinked to the fast skeletal muscle troponin I locus. Thus, the troponin I gene family is dispersed in the mouse genome...
  91. ncbi Gene structure and chromosomal localization of the mouse NMDA receptor channel subunits
    M Nagasawa
    Department of Neuropharmacology, Niigata University, Japan
    Brain Res Mol Brain Res 36:1-11. 1996
    ..Each of these genes mapped to a single chromosome location. The mapping results assigned the five loci to five different mouse autosomes, indicating that they have become well dispersed among mouse chromosomes...
  92. ncbi Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7
    K Kalman
    Department of Physiology, University of California Irvine, Irvine, California 92697, USA
    J Biol Chem 273:5851-7. 1998
    ..In situ hybridization demonstrates the presence of Kv1.7 in mouse pancreatic islet cells. Kv1.7 was also isolated from mouse brain and hamster insulinoma cells by polymerase chain reaction...
  93. ncbi Juvenile bare: a new hair loss mutation on chromosome 7 of the mouse
    P W Lane
    Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Hered 89:254-7. 1998
    ..The hair loss is caused by a recessive mutation, which we have named juvenile bare (jb), located on proximal chromosome 7...
  94. ncbi Chromosomal mapping of five mouse G protein gamma subunits
    G B Downes
    Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri, 63110, USA
    Genomics 57:173-6. 1999
    ..Combined with previous mapping studies, these data indicate that, with the possible exception of gamma1 and gamma11, the G protein gamma subunit genes are well dispersed within the mouse and human genomes...
  95. ncbi Enzyme-activity mutants in Mus musculus. I. Phenotypic description and genetic characterization of ethylnitrosourea-induced mutations
    W Pretsch
    GSF National Research Center for Environment and Health, Institute of Mammalian Genetics, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
    Mamm Genome 11:537-42. 2000
    ..Genetic and biochemical characterizations were routinely performed. These mutants provide insight into the mechanism of ENU mutagenesis and can serve as models for structure-function studies of the corresponding enzymes...
  96. ncbi How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease
    Isao Matsumoto
    Section on Immunology and Immunogenetics, Joslin Diabetes Center Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 1 Joslin Place, Boston, MA 02115, USA
    Nat Immunol 3:360-5. 2002
    ..pathogenic immunoglobulins (Igs) that recognize the ubiquitous cytoplasmic enzyme glucose-6-phosphate isomerase (GPI)...
  97. ncbi Tumor autocrine motility factor induces hyperpermeability of endothelial and mesothelial cells leading to accumulation of ascites fluid
    Tatsuyoshi Funasaka
    Department of Hygienics, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu 502 8585, Japan
    Biochem Biophys Res Commun 293:192-200. 2002
    ..Here, we report a new factor that is involved in this process, e.g., autocrine motility factor (AMF)...
  98. ncbi The roles of Pax6 in the cornea, retina, and olfactory epithelium of the developing mouse embryo
    J Martin Collinson
    Division of Reproductive and Developmental Sciences, Genes and Development Group, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, Scotland, UK
    Dev Biol 255:303-12. 2003
  99. ncbi Chromosomal localization, hematologic characterization, and iron metabolism of the hereditary erythroblastic anemia (hea) mutant mouse
    Robert A White
    Children s Mercy Hospitals and Clinics, Pediatric Research Center, 4th Floor, 2401 Gillham Rd, Kansas City, MO 64108, USA
    Blood 104:1511-8. 2004
    ..When this diet is removed there is reversion to anemia with concomitant loss of overloaded iron stores. We speculate that the hea/fsn gene is required for iron uptake into erythropoietic cells and for kidney iron reabsorption...
  100. ncbi The crystal structure of mouse phosphoglucose isomerase at 1.6A resolution and its complex with glucose 6-phosphate reveals the catalytic mechanism of sugar ring opening
    J T Graham Solomons
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Mol Biol 342:847-60. 2004
    b>Phosphoglucose isomerase (PGI) is an enzyme of glycolysis that interconverts glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P) but, outside the cell, is a multifunctional cytokine...
  101. pmc Glutamate oxaloacetate transaminase (got) genetics in the mouse: polymorphism of got-1
    V M Chapman
    Department of Biology, Kline Biology Tower, Yale University, New Haven, Connecticut 06520
    Genetics 70:299-305. 1972
    ..Furthermore, no close linkage of Got-1 and the loci c, Gpi-1, Mod-2, Mod-1, Ld-1, Gpd-1, Pgm-1 or Gpo-1 was observed...