Genomes and Genes
Gene Symbol: Gria1
Description: glutamate receptor, ionotropic, AMPA1 (alpha 1)
Alias: 2900051M01Rik, Glr-1, Glr1, GluA1, GluR-A, GluRA, Glur-1, Glur1, HIPA1, gluR-K1, glutamate receptor 1, AMPA-selective glutamate receptor 1, glutamate receptor A, glutamate receptor ionotropic, AMPA 1
Publications126 found, 100 shown here
- Distinct spatiotemporal expression of EFA6D, a guanine nucleotide exchange factor for ARF6, among the EFA6 family in mouse brainHiroyuki Sakagami
Division of Histology, Department of Cell Biology, Graduate School of Medicine, Tohoku University, Sendai 980 8574, Japan
Brain Res 1093:1-11. 2006..Furthermore, immunoblot analysis revealed that EFA6D was highly concentrated in the postsynaptic density fraction. These findings suggest differential spatiotemporal regulation of ARF6 by three members of the EFA6 family in the brain...
- Recruitment of parvalbumin-positive interneurons determines hippocampal function and associated behaviorElke C Fuchs
Department of Clinical Neurobiology, University Hospital of Neurology, IZN, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany
Neuron 53:591-604. 2007..These findings directly show the effects of insufficient recruitment of fast-spiking cells at the network and behavioral level and demonstrate the role of this subpopulation for working and episodic-like memory...
- Deletion of glutamate receptor-A (GluR-A) AMPA receptor subunits impairs one-trial spatial memoryD J Sanderson
Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom
Behav Neurosci 121:559-69. 2007Genetically modified mice lacking the glutamate receptor A (GluR-A) subunit of the AMPA receptor (GluR-A-/- mice) display normal spatial reference memory but impaired spatial working memory (SWM)...
- Neuromodulators control the polarity of spike-timing-dependent synaptic plasticityGeun Hee Seol
The Mind Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA
Neuron 55:919-29. 2007..These findings indicate that cholinergic and adrenergic neuromodulation associated with the behavioral state of the animal can control the gating and the polarity of cortical plasticity...
- Emotion enhances learning via norepinephrine regulation of AMPA-receptor traffickingHailan Hu
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
Cell 131:160-73. 2007..Toward this aim, we have examined the role of NE in contextual memory formation and in the synaptic delivery of GluR1-containing alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA)-type glutamate receptors during long-..
- Roles of fragile X mental retardation protein in dopaminergic stimulation-induced synapse-associated protein synthesis and subsequent alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-4-propionate (AMPA) receptor internalizationHansen Wang
Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada
J Biol Chem 285:21888-901. 2010..of SAPAP3 did not affect surface expression of alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-4-propionate (AMPA) GluR1 receptors induced by D1 receptor activation but impaired their subsequent internalization in cultured PFC neurons; ..
- Regulation of GluR1 abundance in murine hippocampal neurones by serum- and glucocorticoid-inducible kinase 3Nathalie Strutz-Seebohm
Department of Physiology I, University of Tuebingen, 72076 Tuebingen, Germany
J Physiol 565:381-90. 2005..In Xenopus oocytes expressing the AMPA subunit GluR1, we show that SGK3, and to a lesser extent SGK2, but not SGK1, increase glutamate-induced currents by increasing ..
- Ca2+/calmodulin-dependent protein kinase II binds to and phosphorylates a specific SAP97 splice variant to disrupt association with AKAP79/150 and modulate alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor (AMPAR) activityYelyzaveta A Nikandrova
Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37232, USA
J Biol Chem 285:923-34. 2010Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) promotes trafficking and activation of the GluR1 subunit of alpha-amino- 3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptors (AMPARs) during synaptic plasticity...
- Tumor necrosis-factor-alpha (TNF-alpha) induces rapid insertion of Ca2+-permeable alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA)/kainate (Ca-A/K) channels in a subset of hippocampal pyramidal neuronsFumio Ogoshi
Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA 92697 4292, USA
Exp Neurol 193:384-93. 2005..factor-alpha (TNF-alpha) was shown to increase the cell surface expression of an AMPA receptor (AMPAR) subunit (GluR1) and to potentiate vulnerability to AMPAR-mediated injury...
- Targeted deletion of the GluR-1 AMPA receptor in mice dissociates general and outcome-specific influences of appetitive rewards on learningAlexander W Johnson
School of Psychology, Cardiff University, UK
Behav Neurosci 121:1192-202. 2007..The results support the hypothesis that GluR-1 deletion impairs the associative activation of a representation of the sensory-specific incentive motivational properties of an appetitive reward...
- A role for alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid GluR1 phosphorylation in the modulatory effects of appetitive reward cues on goal-directed behaviorHans S Crombag
Department of Psychological and Brain Sciences, Neurogenetics and Behavior Center, The Johns Hopkins University, Baltimore, MD, USA
Eur J Neurosci 27:3284-91. 2008..Using homologous recombination (knock-in) techniques we targeted two phosphorylation sites on the AMPA-GluR1 receptor: the Ser831 site, phosphorylated by calcium calmodulin-dependent protein kinase II/protein kinase C, and ..
- Fibroblast growth factor receptor 1 is required for the proliferation of hippocampal progenitor cells and for hippocampal growth in mouseYasushi Ohkubo
Child Study Center, Yale University, New Haven, Connecticut 06520, USA
J Neurosci 24:6057-69. 2004..We conclude that Fgfr1 is necessary for hippocampal growth, because it promotes the proliferation of hippocampal progenitors and stem cells during development...
- Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptorShigeo Uchino
Department of Neurochemistry, National Institute of Neuroscience, Kodaira, Tokyo, Japan
J Neurochem 97:1203-14. 2006..of AMPA receptor trafficking, we performed a yeast two-hybrid screening system using the cytoplasmic tail of the GluR1 subunit of AMPA receptor as a bait and identified a synaptic molecule, Shank3/ProSAP2, as a GluR1 subunit-..
- A synaptic model of memory: long-term potentiation in the hippocampusT V Bliss
Division of Neurophysiology and Neuropharmacology, National Institute of Medical Research, Mill Hill, London, UK
Nature 361:31-9. 1993....
- Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learningD Zamanillo
Department of Molecular Neuroscience, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
Science 284:1805-11. 1999..The results suggest that CA1 hippocampal LTP is controlled by the number or subunit composition of AMPA receptors and show a dichotomy between LTP in CA1 and acquisition of spatial memory...
- Impairment of AMPA receptor function in cerebellar granule cells of ataxic mutant mouse stargazerK Hashimoto
Department of Physiology, Jichi Medical School, Minamikawachi Machi, Tochigi Ken 329 0498, Japan
J Neurosci 19:6027-36. 1999..These results suggest that the defect in MF to GC synaptic transmission is a major factor that causes the cerebellar dysfunction in the stg mutant mouse...
- Morphine-induced dependence and sensitization are altered in mice deficient in AMPA-type glutamate receptor-A subunitsO Y Vekovischeva
Department of Pharmacology and Clinical Pharmacology, University of Turku, FIN 20520 Turku, Finland
J Neurosci 21:4451-9. 2001..The results indicate that AMPA receptors are involved in the acute and chronic effects of morphine, including context-independent sensitization, and that the GluR-A subunit itself is important for morphine tolerance and dependence...
- Conditional restoration of hippocampal synaptic potentiation in Glur-A-deficient miceV Mack
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
Science 292:2501-4. 2001..is dependent on l-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors containing the glutamate receptor A (GluR-A) subunit...
- Molecular dissection of hippocampal theta-burst pairing potentiationD A Hoffman
Abteilung Zellphysiologie and Molekulare Neurobiologie, Max Planck Institut fur medizinische Forschung, Jahnstrasse 29, D 69120 Heidelberg, Germany
Proc Natl Acad Sci U S A 99:7740-5. 2002..The two components of synaptic potentiation could be relevant for different forms of information storage that are dependent on hippocampal synaptic transmission such as spatial reference and working memory...
- Spatial memory dissociations in mice lacking GluR1D Reisel
Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, OX1 3UD, UK
Nat Neurosci 5:868-73. 2002Gene-targeted mice lacking the AMPA receptor subunit GluR1 (GluR-A) have deficits in hippocampal CA3-CA1 long-term potentiation...
- Selective disruption of stimulus-reward learning in glutamate receptor gria1 knock-out miceAndy N Mead
Laboratory of Experimental Psychology, University of Sussex, Brighton BN1 9QG, United Kingdom
J Neurosci 23:1041-8. 2003..AMPA receptor glutamate receptor 1 (GluR1) subunits play a critical role in long-term potentiation (LTP)...
- Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memoryHey Kyoung Lee
Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
Cell 112:631-43. 2003..We previously reported that phosphorylation of the GluR1 subunit of AMPA receptors, which mediate rapid excitatory transmission in the brain, is modulated during LTP and ..
- A within-subjects, within-task demonstration of intact spatial reference memory and impaired spatial working memory in glutamate receptor-A-deficient miceWolfram B Schmitt
Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, United Kingdom
J Neurosci 23:3953-9. 2003Gene-targeted mice lacking the AMPA receptor subunit glutamate receptor-A (GluRA) (GluR1) and wild-type controls were compared on a radial-maze task in which the same three of six arms were always baited, but in which the rewards of milk ..
- Impaired regulation of synaptic strength in hippocampal neurons from GluR1-deficient miceBertalan K Andrasfalvy
Neuroscience Center, Louisiana State University Health Science Center, 2020 Gravier Street, New Orleans, LA 70112, USA
J Physiol 552:35-45. 2003..In fact, glutamate receptor 1 (GluR1 or GluRA) subunits containing L-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) ..
- A juvenile form of postsynaptic hippocampal long-term potentiation in mice deficient for the AMPA receptor subunit GluR-AVidar Jensen
Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, PO Box 1103 Blindern, N0317 Oslo, Norway
J Physiol 553:843-56. 2003..Our results show that in the developing hippocampus synaptic plasticity can be expressed by AMPA receptors lacking the GluR-A subunit...
- Aberrant formation of glutamate receptor complexes in hippocampal neurons of mice lacking the GluR2 AMPA receptor subunitNathalie Sans
Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892 8027, USA
J Neurosci 23:9367-73. 2003..Our data indicate that in the absence of GluR2, aberrant receptor complexes composed of GluR1 and GluR3 are formed in the hippocampus, and that there is an increased number of homomeric GluR1 and GluR3 ..
- The role of hippocampal glutamate receptor-A-dependent synaptic plasticity in conditional learning: the importance of spatiotemporal discontiguityWolfram B Schmitt
Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, United Kingdom
J Neurosci 24:7277-82. 2004Gene-targeted mice lacking the AMPA receptor subunit glutamate receptor-A (GluR-A or GluR1) and mice with cytotoxic hippocampal lesions were compared with wild-type and sham-operated controls, respectively, on a conditional learning task ..
- Reduced aggression in AMPA-type glutamate receptor GluR-A subunit-deficient miceO Y Vekovischeva
Institute of Biomedicine Pharmacology, Biomedicum Helsinki, University of Helsinki, Finland
Genes Brain Behav 3:253-65. 2004....
- The AMPA receptor subunits GluR-A and GluR-B reciprocally modulate spinal synaptic plasticity and inflammatory painBettina Hartmann
Institute for Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
Neuron 44:637-50. 2004..Thus, AMPA receptors are not mere determinants of fast synaptic transmission underlying basal pain sensitivity as previously thought, but are critically involved in activity-dependent changes in synaptic processing of nociceptive inputs...
- Effects of deletion of gria1 or gria2 genes encoding glutamatergic AMPA-receptor subunits on place preference conditioning in miceAndy N Mead
Department of Psychology, School of Life Sciences, University of Sussex, BN1 9QG, UK
Psychopharmacology (Berl) 179:164-71. 2005..Critically, this classical conditioning procedure requires the formation of associations between a rewarding stimulus and environmental cues, and the ability of these cues to direct subsequent behaviour...
- Restoration of spatial working memory by genetic rescue of GluR-A-deficient miceW B Schmitt
Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, OX1 3UD, UK
Nat Neurosci 8:270-2. 2005Gene-targeted mice lacking the AMPA receptor subunit GluR-A (also called GluR1 encoded by the gene Gria1,) have deficits in hippocampal CA3-CA1 long-term potentiation (LTP) and have profoundly impaired hippocampus-dependent spatial ..
- Differential roles for group 1 mGluR subtypes in induction and expression of chemically induced hippocampal long-term depressionLenora J Volk
Center for Basic Neuroscience, Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
J Neurophysiol 95:2427-38. 2006..This suggests different receptors and/or upstream mechanisms for chemically and synaptically induced LTD...
- Mice lacking the AMPA GluR1 receptor exhibit striatal hyperdopaminergia and 'schizophrenia-related' behaviorsL M Wiedholz
Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse, NIH, Bethesda, MD 20852, USA
Mol Psychiatry 13:631-40. 2008..study evaluated knockout (KO) mice lacking the L-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) GluR1 receptor subunit for a range of behaviors considered relevant to certain symptoms of schizophrenia...
- Identification and characterization of a novel phosphorylation site on the GluR1 subunit of AMPA receptorsHey Kyoung Lee
Howard Hughes Medical Institute, Solomon H Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
Mol Cell Neurosci 36:86-94. 2007..Here, we identified threonine-840 (T840) on the GluR1 subunit of AMPA receptors as a novel phosphorylation site...
- A pathway-specific function for different AMPA receptor subunits in amygdala long-term potentiation and fear conditioningYann Humeau
Friedrich Miescher Institute for Biomedical Research, CH 4058 Basel, Switzerland
J Neurosci 27:10947-56. 2007The AMPA receptor subunit glutamate receptor 1 (GluR1 or GluR-A) contributes to amygdala-dependent emotional learning...
- NMDA receptor activation dephosphorylates AMPA receptor glutamate receptor 1 subunits at threonine 840Jary Y Delgado
Interdepartmental PhD Program for Neuroscience, University of California, Los Angeles, 90095, USA
J Neurosci 27:13210-21. 2007..Although three previously identified phosphorylation sites in AMPA receptor glutamate receptor 1 (GluR1) subunits (S818, S831, and S845) appear to have important roles in LTP and LTD, little is known ..
- Glutamate receptors on dopamine neurons control the persistence of cocaine seekingDavid Engblom
Division of Molecular Biology of the Cell I, German Cancer Research Center, 69120 Heidelberg, Germany
Neuron 59:497-508. 2008Cocaine strengthens excitatory synapses onto midbrain dopamine neurons through the synaptic delivery of GluR1-containing AMPA receptors...
- FMRP acts as a key messenger for dopamine modulation in the forebrainHansen Wang
Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, ON M5S1A8, Canada
Neuron 59:634-47. 2008..AMPA glutamate receptor subtype 1 (GluR1) surface expression and phosphorylation in response to D1 receptor stimulation were reduced in cultured Fmr1(-/-) ..
- Retinoic acid regulates RARalpha-mediated control of translation in dendritic RNA granules during homeostatic synaptic plasticityBita Maghsoodi
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
Proc Natl Acad Sci U S A 105:16015-20. 2008..transmission by stimulating in dendrites the local translation and synaptic insertion of the AMPA receptor subunit GluR1. We have previously shown that all-trans retinoic acid (RA) mediates activity blockade-induced synaptic scaling by ..
- Postsynaptic action potentials are required for nitric-oxide-dependent long-term potentiation in CA1 neurons of adult GluR1 knock-out and wild-type miceKeith G Phillips
Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK
J Neurosci 28:14031-41. 2008..potentiation (LTP) consists of both presynaptic and postsynaptic components that rely on nitric oxide (NO) and the GluR1 subunit of the AMPA receptor, respectively...
- Induction and expression of GluA1 (GluR-A)-independent LTP in the hippocampusCarola Romberg
Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
Eur J Neurosci 29:1141-52. 2009..Here we used genetically modified mice lacking the GluA1 subunit (Gria1(-/-) mice) to investigate GluA1-independent mechanisms of LTP at CA3-CA1 synapses in transverse hippocampal slices...
- Activity pattern-dependent long-term potentiation in neocortex and hippocampus of GluA1 (GluR-A) subunit-deficient miceMarco C Frey
Department of Cell Physiology, Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
J Neurosci 29:5587-96. 2009The AMPA receptor subunit GluA1 (GluR-A) has been implicated to be critically involved in the expression of long-term potentiation (LTP) and memory formation. Mice lacking this subunit possess a profound spatial working memory deficit...
- Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approachWei Lu
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA
Neuron 62:254-68. 2009..is of particular importance with regard to AMPA-type glutamate receptors, the multimeric complexes assembled from GluA1-A4 subunits, as the trafficking of these receptors into and out of synapses is proposed to depend upon the subunit ..
- Enhanced long-term and impaired short-term spatial memory in GluA1 AMPA receptor subunit knockout mice: evidence for a dual-process memory modelDavid J Sanderson
Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, United Kingdom
Learn Mem 16:379-86. 2009The GluA1 AMPA receptor subunit is a key mediator of hippocampal synaptic plasticity and is especially important for a rapidly-induced, short-lasting form of potentiation...
- Regulation of AMPA receptor extrasynaptic insertion by 4.1N, phosphorylation and palmitoylationDa Ting Lin
Department of Neuroscience and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Nat Neurosci 12:879-87. 2009..By directly visualizing individual insertion events of the AMPAR subunit GluR1 in rodents, we found that the protein 4.1N was required for activity-dependent GluR1 insertion...
- TARP modulation of synaptic AMPA receptor trafficking and gating depends on multiple intracellular domainsAaron D Milstein
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 106:11348-51. 2009....
- Stabilization of Ca2+-permeable AMPA receptors at perisynaptic sites by GluR1-S845 phosphorylationKaiwen He
Department of Biology, College of Chemical and Life Sciences and Neuroscience and Cognitive Science NACS Program, University of Maryland, College Park, MD 20742, USA
Proc Natl Acad Sci U S A 106:20033-8. 2009..Certain types of neural activity can recruit Ca(2+)-permeable (CP) AMPARs, such as GluR1 homomers, to synapses likely via lateral diffusion from extrasynaptic sites...
- Specific roles of AMPA receptor subunit GluR1 (GluA1) phosphorylation sites in regulating synaptic plasticity in the CA1 region of hippocampusHey Kyoung Lee
Department of Biology, College of Chemical and Life Sciences, University of Maryland, College Park, MD, USA
J Neurophysiol 103:479-89. 2010..In particular, several lines of evidence suggest that reversible phosphorylation of AMPAR subunit glutamate receptor 1 (GluR1, also referred to as GluA1 or GluR-A) plays a role in long-term potentiation (LTP) and long-term ..
- A single brief burst induces GluR1-dependent associative short-term potentiation: a potential mechanism for short-term memoryMartha A Erickson
Brandeis University, Waltham, MA, USA
J Cogn Neurosci 22:2530-40. 2010..Sprengel, R., Seeburg, P. H., Nicholas, J., et al. Enhanced long-term and impaired short-term spatial memory in GluA1 AMPA receptor subunit knockout mice: Evidence for a dual-process memory model...
- Spatial working memory deficits in GluA1 AMPA receptor subunit knockout mice reflect impaired short-term habituation: evidence for Wagner's dual-process memory modelDavid J Sanderson
Department of Experimental Psychology, University of Oxford, Oxford, UK
Neuropsychologia 48:2303-15. 2010Genetically modified mice, lacking the GluA1 AMPA receptor subunit, are impaired on spatial working memory tasks, but display normal acquisition of spatial reference memory tasks...
- Does gene deletion of AMPA GluA1 phenocopy features of schizoaffective disorder?Paul J Fitzgerald
Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20852 9411, USA
Neurobiol Dis 40:608-21. 2010Glutamatergic dysfunction is strongly implicated in schizophrenia and mood disorders. GluA1 knockout (KO) mice display schizophrenia- and depression-related abnormalities. Here, we asked whether GluA1 KO show mania-related abnormalities...
- Calcium-permeable AMPA receptor dynamics mediate fear memory erasureRoger L Clem
Department of Neuroscience and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Science 330:1108-12. 2010..A transient up-regulation of this form of plasticity, which involves phosphorylation of the glutamate receptor 1 subunit of the AMPA receptor, defines a temporal window in which fear memory can be degraded by behavioral ..
- Excessive novelty-induced c-Fos expression and altered neurogenesis in the hippocampus of GluA1 knockout miceChiara Procaccini
Institute of Biomedicine Pharmacology, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
Eur J Neurosci 33:161-74. 2011Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor GluA1 subunit-deficient (GluA1-/-) mice display novelty-induced hyperactivity, cognitive and social defects and may model psychiatric disorders, such as schizophrenia ..
- Deletion of the GluA1 AMPA receptor subunit alters the expression of short-term memoryDavid J Sanderson
Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, United Kingdom
Learn Mem 18:128-31. 2011Deletion of the GluA1 AMPA receptor subunit selectively impairs short-term memory for spatial locations. We further investigated this deficit by examining memory for discrete nonspatial visual stimuli in an operant chamber...
- Deletion of the GluA1 AMPA receptor subunit impairs recency-dependent object recognition memoryDavid J Sanderson
Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, OX1 3UD, United Kingdom
Learn Mem 18:181-90. 2011Deletion of the GluA1 AMPA receptor subunit impairs short-term spatial recognition memory...
- Phosphorylation of AMPA receptors is required for sensory deprivation-induced homeostatic synaptic plasticityAnubhuti Goel
Department of Biology, University of Maryland, College Park, Maryland, United States of America
PLoS ONE 6:e18264. 2011..scaling in visual cortex of juvenile rodents, is accompanied by an increase in the phosphorylation of AMPAR GluR1 (or GluA1) subunit at the serine 845 (S845) site and the appearance of CP-AMPARs at synapses...
- Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3Xiaoming Wang
Department of Pediatrics, Duke University School of Medicine, Durham, NC 27710, USA
Hum Mol Genet 20:3093-108. 2011..Shank3(e4-9) mice have reduced levels of Homer1b/c, GKAP and GluA1 at the PSD, and show attenuated activity-dependent redistribution of GluA1-containing AMPA receptors...
- Do GluA1 knockout mice exhibit behavioral abnormalities relevant to the negative or cognitive symptoms of schizophrenia and schizoaffective disorder?Chris Barkus
Department of Experimental Psychology, South Parks Road, University of Oxford, UK
Neuropharmacology 62:1263-72. 2012..We recently found that knockout (KO) mice lacking the AMPA GluA1 subunit displayed behavioral abnormalities relevant to some of the positive symptoms of these disorders...
- Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depressionSadegh Nabavi
Center for Neural Circuits and Behavior, Division of Biology, Department of Neuroscience and Section of Neurobiology, University of California at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 110:4027-32. 2013..Our findings indicate that metabotropic actions of NMDARs can weaken active synapses without raising postsynaptic calcium, thereby revising and expanding the mechanisms controlling synaptic plasticity...
- Low density lipoprotein receptor-related protein 1 (LRP1) modulates N-methyl-D-aspartate (NMDA) receptor-dependent intracellular signaling and NMDA-induced regulation of postsynaptic protein complexesChikako Nakajima
Department of Medicine II, University Hospital and University of Freiburg, 79104 Freiburg, Germany
J Biol Chem 288:21909-23. 2013..Accordingly, NMDA-induced internalization of the AMPA receptor subunit GluA1 was impaired in LRP1-deficient neurons...
- Persistent synaptic scaling independent of AMPA receptor subunit compositionHaider F Altimimi
Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal, Quebec H3G 1A4, Canada
J Neurosci 33:11763-7. 2013..Similar to LTP, the GluA1 subunit has been suggested to be the requisite subunit for HSP-induced AMPAR insertion and acute treatment with ..
- Reversal of novelty-induced hyperlocomotion and hippocampal c-Fos expression in GluA1 knockout male mice by the mGluR2/3 agonist LY354740C Procaccini
Institute of Biomedicine Pharmacology, Biomedicum Helsinki, P O B 63, FIN 00014 University of Helsinki, Finland
Neuroscience 250:189-200. 2013..As a putative model for these disorders, a mouse line lacking the GluA1 subunit (GluA1-KO) of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor displays ..
- Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3)Nyaya Kelkar
Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
Proc Natl Acad Sci U S A 100:9843-8. 2003..The central nervous system abnormalities of Jip3-/- mice may be accounted for in part by a reduction in signal transduction by RhoA and its effector ROCK...
- Spatial reference memory in GluR-A-deficient mice using a novel hippocampal-dependent paddling pool escape taskW B Schmitt
Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford OX1 3UD, UK
Hippocampus 14:216-23. 2004..modified mice lacking the L-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptor subunit, GluR-A (GluR1), and deficient in hippocampal CA3-CA1 long-term potentiation (LTP), were assessed on a novel, hippocampal-..
- Differential regulation of AMPA receptor subunit trafficking by palmitoylation of two distinct sitesTakashi Hayashi
Howard Hughes Medical Institute, Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA
Neuron 47:709-23. 2005..These data suggest that regulated palmitoylation of AMPA receptor subunits modulates receptor trafficking and may be important for synaptic plasticity...
- Calsyntenin-1, a proteolytically processed postsynaptic membrane protein with a cytoplasmic calcium-binding domainL Vogt
Institute of Biochemistry, Institute of Anatomy, University of Zurich, Winterthurerstrasse 190, Zurich, CH 8057, Switzerland
Mol Cell Neurosci 17:151-66. 2001..Thus, calsyntenin-1 may link extracellular proteolysis in the synaptic cleft and postsynaptic Ca2+ signaling...
- Impaired outcome-specific devaluation of instrumental responding in mice with a targeted deletion of the AMPA receptor glutamate receptor 1 subunitAlexander W Johnson
School of Psychology, Cardiff University, Cardiff CF10 3YG, United Kingdom
J Neurosci 25:2359-65. 2005The present study evaluated the proposal that mice with a targeted deletion of the glutamate receptor 1 (GluR1) subunit of the AMPA receptor are impaired in using an instrumental or pavlovian signal to gain access to a representation of ..
- Synapse-specific regulation of AMPA receptor subunit composition by activityKimberly J Harms
Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Neurosci 25:6379-88. 2005..However, silenced neurons could not recruit the AMPA-type glutamate receptor subunit GluR1 as efficiently when competing with active neighbors...
- Glutamate mediates platelet activation through the AMPA receptorCraig N Morrell
Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Exp Med 205:575-84. 2008..In contrast, platelets treated with the AMPAR antagonist CNQX or platelets derived from GluR1 knockout mice are resistant to AMPA effects...
- Superresolution imaging of chemical synapses in the brainAdish Dani
Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA
Neuron 68:843-56. 2010..Combination with optogenetics further allowed molecular events associated with synaptic plasticity to be resolved at the single-synapse level...
- Individual stress vulnerability is predicted by short-term memory and AMPA receptor subunit ratio in the hippocampusMathias V Schmidt
Research Group Neurobiology of Stress, Max Planck Institute of Psychiatry, 80804 Munich, Germany
J Neurosci 30:16949-58. 2010..Finally, we provide evidence that genetic variations in the AMPA receptor subunit GluR1 are linked to the vulnerable phenotype...
- The tumor suppressor p53 guides GluA1 homeostasis through Nedd4-2 during chronic elevation of neuronal activityKathryn A Jewett
Department of Molecular and Integrative Physiology, School of Molecular and Cellular Biology, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
J Neurochem 135:226-33. 2015..Nedd4-2 encodes another ubiquitin E3 ligase. We identified glutamate receptor subunit 1 (GluA1), subunit of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors as a novel substrate of Nedd4-2...
- Glutamate receptor 1-immunopositive neurons in the gliotic CA1 area of the mouse hippocampus after pilocarpine-induced status epilepticusFeng Ru Tang
Epilepsy Research Laboratory, National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore 308433
Eur J Neurosci 21:2361-74. 2005Significant reduction in glutamate receptor 1 (GluR1)- and GluR2/3-immunopositive neurons was demonstrated in the hilus of the dentate gyrus in mice killed on days 1, 7 and 60 after pilocarpine-induced status epilepticus (PISE)...
- Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapsesChiara Verpelli
Department of Pharmacology, CNR Institute of Neuroscience, University of Milan, Milan 20129, Italy
J Biol Chem 286:34839-50. 2011....
- Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptorsNicola J Allen
Stanford University School of Medicine, Department of Neurobiology, 299 Campus Drive, Fairchild Science Building D231, Stanford, California 94305 5125, USA
Nature 486:410-4. 2012..This is achieved by increasing the surface level and clustering, but not overall cellular protein level, of the GluA1 subunit of the AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) glutamate receptor (AMPAR)...
- Deficits in LTP induction by 5-HT2A receptor antagonist in a mouse model for fragile X syndromeZhao hui Xu
Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi an, China
PLoS ONE 7:e48741. 2012..Furthermore, 5-HT2AR inhibition induced AMPA receptor GluR1 subtype surface insertion in the cultured ACC neurons of Fmr1 WT mice, however, GluR1 surface insertion by ..
- Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmissionMarc P Lussier
Receptor Biology Section and Biochemistry Section Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 109:19426-31. 2012..Therefore, our study identifies RNF167 as a selective regulator of AMPAR-mediated neurotransmission and expands our understanding of how ubiquitination dynamically regulates excitatory synapses...
- Synaptic profiles during neurite extension, refinement and retraction in the developing cochleaLin Chien Huang
Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
Neural Dev 7:38. 2012..The OHC connections are then selectively eliminated, leaving sparse innervation by type II afferent fibres, whilst the type I afferent synapses with IHCs are consolidated...
- Expression of the metabotropic glutamate receptor mGluR1 alpha and the ionotropic glutamate receptor GluR1 in the brain during the postnatal development of normal mouse and in the cerebellum from mutant miceY Ryo
Department of Molecular Neurobiology, University of Tokyo, Japan
J Neurosci Res 36:19-32. 1993..receptor type 1 alpha (mGluR1 alpha) and the non-N-methyl-D-aspartate (NMDA) ionotropic glutamate receptor type 1 (GluR1) in mouse brain was investigated using the antibodies raised against the synthetic peptides corresponding to their ..
- Allosteric modulation of AMPA-type glutamate receptors increases activity of the promoter for the neural cell adhesion molecule, N-CAMB D Holst
Department of Neurobiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 95:2597-602. 1998....
- Glutamate receptors: brain function and signal transductionS Nakanishi
Department of Biological Sciences, Kyoto University Faculty of Medicine, Yoshida, Sakyo ku, Kyoto 606, Japan
Brain Res Brain Res Rev 26:230-5. 1998..Thus, the two closely related mGluR subtypes mediate diverging intracellular signaling in glutamate transmission...
- A phylogenetic analysis reveals an unusual sequence conservation within introns involved in RNA editingP J Aruscavage
Department of Biochemistry Howard Hughes Medical Institute, University of Utah, Salt Lake City 84132, USA
RNA 6:257-69. 2000..The approximately 600-nt intron 13 of gluR-C was particularly remarkable, showing >94% nucleotide identity between human and chicken, organisms estimated to have diverged 310 million years ago...
- BDNF regulates spontaneous correlated activity at early developmental stages by increasing synaptogenesis and expression of the K+/Cl- co-transporter KCC2Fernando Aguado
Department of Cell Biology Faculty of Biology, and Barcelona Science Park, University of Barcelona, Barcelona 08028, Spain
Development 130:1267-80. 2003..Given that BDNF itself is regulated by neuronal activity, we suggest that BDNF acts as a homeostatic factor controlling the emergence, complexity and networking properties of spontaneous networks...
- Cocaine-induced potentiation of synaptic strength in dopamine neurons: behavioral correlates in GluRA(-/-) miceY Dong
Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94305, USA
Proc Natl Acad Sci U S A 101:14282-7. 2004..This enhancement requires the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit GluRA as evidenced by its absence in mice lacking this subunit...
- Molecular constituents of neuronal AMPA receptorsYuko Fukata
Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
J Cell Biol 169:399-404. 2005..AMPARs: an immature complex with the endoplasmic reticulum chaperone immunoglobulin-binding protein and a mature complex containing GluR1, TARPs, and PSD-95. These studies establish TARPs as the auxiliary components of neuronal AMPARs.
- Persistent hippocampal CA1 LTP in mice lacking the C-terminal PDZ ligand of GluR1Chong Hyun Kim
Department of Neuroscience and Howard Hughes Medical Institute, The Johns Hopkins University, Baltimore, Maryland 21205, USA
Nat Neurosci 8:985-7. 2005The C-terminal PDZ ligand of the AMPA receptor GluR1 subunit may be important for expression of CA1 hippocampal long-term potentiation...
- Gene expression differences in mice divergently selected for methamphetamine sensitivityAbraham A Palmer
Columbia Genome Center, Columbia University, 1150 St Nicholas Ave, New York, New York 10032, USA
Mamm Genome 16:291-305. 2005..detected for several genes, including Casein Kinase 1 Epsilon (Csnkle), glutamate receptor, ionotropic, AMPA1 (GluR1), GABA B1 receptor (Gabbr1), and dopamine- and cAMP-regulated phosphoprotein of 32 kDa (Darpp-32). We used the www...
- Differential co-expression of AMPA receptor subunits in substance P receptor-containing neurons of basal forebrain regions of C57/BL miceJin Ping Zhang
Institute of Neurosciences, The Fourth Military Medical University, Shaanxi, Xi an 710032, PR China
Neurochem Int 49:319-26. 2006..co-expression patterns of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA) receptor subunits 1-4 (GluR1-4) in substance P receptor (SPR)-containing neurons of the basal forebrain, which may act as a morphological basis ..
- Unipolar brush cells of the cerebellum are produced in the rhombic lip and migrate through developing white matterChris Englund
Department of Pathology, University of Washington, Seattle, Washington 98104, USA
J Neurosci 26:9184-95. 2006..Our findings support a model of cerebellar neurogenesis, in which glutamatergic and GABAergic neurons are produced from separate progenitor pools located mainly in the rhombic lip and the cerebellar ventricular zone, respectively...
- Auditory sensitivity regulation via rapid changes in expression of surface AMPA receptorsZhiqiang Chen
Department of Otology and Laryngology, Harvard Medical School, 243 Charles Street, Boston, Massachusetts 02114, USA
Nat Neurosci 10:1238-40. 2007..Thus we show that AMPA receptor cycling is important for optimizing synaptic transfer at one of the most exacting synapses in the body...
- Nicotine regulates multiple synaptic proteins by inhibiting proteasomal activityKhosrow Rezvani
Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci 27:10508-19. 2007..The same nicotine treatment increased the levels of the AMPA glutamate receptor subunit GluR1, the NMDA receptor subunit NR2A, the metabotropic receptor mGluR1alpha, the plasticity factor Homer-1A, and the ..
- Altered presymptomatic AMPA and cannabinoid receptor trafficking in motor neurons of ALS model mice: implications for excitotoxicityPingwei Zhao
Forbes Norris ALS MDA Research Center, California Pacific Medical Center Research Institute, 475 Brannan St, Suite 220, San Francisco, CA 94107, USA
Eur J Neurosci 27:572-9. 2008..the synaptic localization of specific subclasses of AMPARs [as determined by the presence of the subunits glutamate receptor 1 (GluR1) or glutamate receptor 2 (GluR2)] and CB1 in spinal cord motor neurons during disease progression in ..
- GluR1 controls dendrite growth through its binding partner, SAP97Weiguo Zhou
Department of Pediatrics, Division of Neurology, Joseph Stokes Jr Research Institute, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Neurosci 28:10220-33. 2008..In the present study, we examined the mechanism by which the GluR1 subunit of AMPA receptors controls dendrite morphogenesis...
- Vulnerability of white matter towards antenatal hypoxia is linked to a species-dependent regulation of glutamate receptor subunitsRomain H Fontaine
Institut National de la Sante et de la Recherche Medicale, AVENIR RO5230HS, Paris, France
Proc Natl Acad Sci U S A 105:16779-84. 2008..Gestational hypoxia may regulate the expression of specific glutamate-receptor subunits in fetal mice but not in fetal rats. Therefore, genetic factors may influence the susceptibility of rodents to WMD...
- Mechanism of Ca2+/calmodulin-dependent kinase II regulation of AMPA receptor gatingAnders S Kristensen
Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, USA
Nat Neurosci 14:727-35. 2011..Ca(2+)/calmodulin-dependent kinase II (CaMKII) phosphorylates the GluA1 AMPA receptor subunit at Ser831 to increase single-channel conductance...
- High-throughput analysis of promoter occupancy reveals new targets for Arx, a gene mutated in mental retardation and interneuronopathiesMarie Lise Quille
INSERM U613, Brest, France
PLoS ONE 6:e25181. 2011..Overall, these results identified multiple new candidate targets for Arx and should help to better understand the pathophysiological mechanisms of intellectual disability and epilepsy associated with ARX mutations...
- The TiPS/TINS lecture: the molecular biology of mammalian glutamate receptor channelsP H Seeburg
University of Heidelberg, Centre of Molecular Biology ZMBH, Germany
Trends Pharmacol Sci 14:297-303. 1993..This review describes the different channel types obtained by recombinant means and the genetic mechanisms controlling the expression of functionally important channel structures...
- AMPA receptor subunits expressed by single astrocytes in the juvenile mouse hippocampusG Seifert
Institute of Physiology, Department of Neurophysiology, Friedrich Schiller University Jena, Germany
Brain Res Mol Brain Res 47:286-94. 1997..The glial receptors might be involved in the modulation of gene expression as well as the regulation of proliferation and differentiation...
- Cloning of novel splice variants of mouse mGluR1H Zhu
Laboratory for Cancer Research, Chemical Biology Department, College of Pharmacy, Rutgers University, Piscataway, NJ 08855, USA
Brain Res Mol Brain Res 73:93-103. 1999Three splice variants of the mouse metabotropic glutamate receptor 1, mGluR1E55, mGluR1a and mGluR1b, have been isolated from mouse brain cDNA libraries. The sequences of mGluR1a and mGluR1b are similar to those from rat and human...
- mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordinationT Ichise
Laboratory of DNA Biology and Embryo Engineering, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
Science 288:1832-5. 2000..The impaired motor coordination was rescued by this transgene, in a dose-dependent manner. We propose that mGluR1 in PCs is a key molecule for normal synapse formation, synaptic plasticity, and motor control in the cerebellum...
- Presynaptic inhibition caused by retrograde signal from metabotropic glutamate to cannabinoid receptorsT Maejima
Department of Physiology, Kanazawa University School of Medicine, Takara machi, Kanazawa 920 8640, Japan
Neuron 31:463-75. 2001..Our data highlight a signaling mechanism whereby activation of postsynaptic mGluR retrogradely influences presynaptic functions via endocannabinoid system...
- ACTIVITY DEPENDENT MECHANISMS OF VISUAL DEVELOPMENTMriganka Sur; Fiscal Year: 2002..Such approaches are crucial to understanding the complex cellular mechanisms that underlie the development and refinement of connections during pattern formation. ..
- DYNAMIC INTEGRATION IN SOMATOSENSORY CORTEXMriganka Sur; Fiscal Year: 2004..Information from these experiments will be important for understanding the integration of multiple inputs in sensory cortex, and more generally for understanding cortical mechanisrns of object detection and discrimination. ..
- Novel genes underlying connectivity in the visual cortexMriganka Sur; Fiscal Year: 2005..abstract_text> ..
- Cortical Plasticity: Inputs, Networks and BehaviorMriganka Sur; Fiscal Year: 2007..abstract_text> ..
- Structural correlates of rapid cortical plasticityMriganka Sur; Fiscal Year: 2010..Such information is critical for explaining pathologies of cortical development, and for suggesting strategies for treatment. ..
- Molecular and functional mechanisms underlying binocular visionMriganka Sur; Fiscal Year: 2010..The planned experiments promise to elucidate the mechanisms by which Ten_m3 expression affects the development of binocular vision, and thus to provide a novel basis for the design of therapies for visual dysfunction. ..
- Nitric Oxide Regulation of Platelet Granule ExocytosisCRAIG MORRELL; Fiscal Year: 2008..Therefore, strategies to minimize granule exocytosis may prove valuable in the acute treatment of pro-thrombotic diseases. (End of Abstract) [unreadable] [unreadable]..