Gria2

Summary

Gene Symbol: Gria2
Description: glutamate receptor, ionotropic, AMPA2 (alpha 2)
Alias: GluA2, GluR-B, Glur-2, Glur2, glutamate receptor 2, AMPA selective glutamate receptor, AMPA-selective glutamate receptor 2, gluR-K2, glutamate receptor B, glutamate receptor ionotropic, AMPA 2
Species: mouse

Top Publications

  1. pmc RNA editing of the IQ domain in Ca(v)1.3 channels modulates their Ca²⁺-dependent inactivation
    Hua Huang
    Department of Physiology, Yong Loo Lin School Medicine, National University of Singapore, 117597 Singapore
    Neuron 73:304-16. 2012
  2. ncbi Tumor necrosis-factor-alpha (TNF-alpha) induces rapid insertion of Ca2+-permeable alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA)/kainate (Ca-A/K) channels in a subset of hippocampal pyramidal neurons
    Fumio Ogoshi
    Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA 92697 4292, USA
    Exp Neurol 193:384-93. 2005
  3. ncbi The proteoglycan NG2 is complexed with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by the PDZ glutamate receptor interaction protein (GRIP) in glial progenitor cells. Implications for glial-neuronal signaling
    Judith Stegmuller
    Department of Neurobiology, University of Heidelberg, Im Neuenheimer Feld 364, Germany
    J Biol Chem 278:3590-8. 2003
  4. doi Neuronal enriched endosomal protein of 21 kDa colocalizes with glutamate receptor subunit GLUR2/3 at the postsynaptic membrane
    J K Utvik
    Institute of Basic Medical Sciences, Department of Anatomy, University of Oslo, P O Box 1105 Blindern, 0317 Oslo, Norway
    Neuroscience 158:96-104. 2009
  5. doi Linking supply to demand: the neuronal monocarboxylate transporter MCT2 and the alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionic acid receptor GluR2/3 subunit are associated in a common trafficking process
    Karin Pierre
    Departement de Physiologie, Universite de Lausanne, 7 rue du Bugnon, CH 1005 Lausanne, Switzerland
    Eur J Neurosci 29:1951-63. 2009
  6. doi Use of MGLUR2 and MGLUR3 knockout mice to explore in vivo receptor specificity of the MGLUR2/3 selective antagonist LY341495
    A M Linden
    Institute of Biomedicine, Pharmacology, University of Helsinki, Finland
    Neuropharmacology 57:172-82. 2009
  7. ncbi The caveolin scaffolding domain modifies 2-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor binding properties by inhibiting phospholipase A2 activity
    Sophie B Gaudreault
    Douglas Hospital Research Center, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec H4A 2B4, Canada
    J Biol Chem 279:356-62. 2004
  8. ncbi Anxiolytic-like activity of the mGLU2/3 receptor agonist LY354740 in the elevated plus maze test is disrupted in metabotropic glutamate receptor 2 and 3 knock-out mice
    A M Linden
    Neuroscience Research Division, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Psychopharmacology (Berl) 179:284-91. 2005
  9. ncbi Effects of mGlu2 or mGlu3 receptor deletions on mGlu2/3 receptor agonist (LY354740)-induced brain c-Fos expression: specific roles for mGlu2 in the amygdala and subcortical nuclei, and mGlu3 in the hippocampus
    Anni Maija Linden
    Neuroscience Discovery, Lilly Research Laboratories, Central Nervous System Research, Eli Lilly and Company, Lilly Corporate Center, Drop Code 0510, Indianapolis, IN 46285, USA
    Neuropharmacology 51:213-28. 2006
  10. ncbi RNA editing in brain controls a determinant of ion flow in glutamate-gated channels
    B Sommer
    Laboratory for Molecular Neuroendocrinology, University of Heidelberg, Federal Republic of Germany
    Cell 67:11-9. 1991

Scientific Experts

Detail Information

Publications118 found, 100 shown here

  1. pmc RNA editing of the IQ domain in Ca(v)1.3 channels modulates their Ca²⁺-dependent inactivation
    Hua Huang
    Department of Physiology, Yong Loo Lin School Medicine, National University of Singapore, 117597 Singapore
    Neuron 73:304-16. 2012
    ..Our study reveals a mechanism for fine-tuning Ca(v)1.3 channel properties in CNS, which likely impacts a broad spectrum of neurobiological functions...
  2. ncbi Tumor necrosis-factor-alpha (TNF-alpha) induces rapid insertion of Ca2+-permeable alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA)/kainate (Ca-A/K) channels in a subset of hippocampal pyramidal neurons
    Fumio Ogoshi
    Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA 92697 4292, USA
    Exp Neurol 193:384-93. 2005
    ..6 nM, 15 min) induced a rapid increase in cell surface levels not only of GluR1, but also of the AMPAR subunit GluR2, on most neurons, without evident new protein synthesis...
  3. ncbi The proteoglycan NG2 is complexed with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by the PDZ glutamate receptor interaction protein (GRIP) in glial progenitor cells. Implications for glial-neuronal signaling
    Judith Stegmuller
    Department of Neurobiology, University of Heidelberg, Im Neuenheimer Feld 364, Germany
    J Biol Chem 278:3590-8. 2003
    ..AMPA receptor complex in glial-neuronal recognition and signaling...
  4. doi Neuronal enriched endosomal protein of 21 kDa colocalizes with glutamate receptor subunit GLUR2/3 at the postsynaptic membrane
    J K Utvik
    Institute of Basic Medical Sciences, Department of Anatomy, University of Oslo, P O Box 1105 Blindern, 0317 Oslo, Norway
    Neuroscience 158:96-104. 2009
    ..Using immunogold electron microscopy, we show that NEEP21 is colocalized with the AMPAR subunits GluR2/3 in postsynaptic spines...
  5. doi Linking supply to demand: the neuronal monocarboxylate transporter MCT2 and the alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionic acid receptor GluR2/3 subunit are associated in a common trafficking process
    Karin Pierre
    Departement de Physiologie, Universite de Lausanne, 7 rue du Bugnon, CH 1005 Lausanne, Switzerland
    Eur J Neurosci 29:1951-63. 2009
    ..Using immunofluorescence, we show in this study that MCT2 colocalizes extensively with GluR2/3 subunits of AMPA receptors in neurons from various mouse brain regions as well as in cultured neurons...
  6. doi Use of MGLUR2 and MGLUR3 knockout mice to explore in vivo receptor specificity of the MGLUR2/3 selective antagonist LY341495
    A M Linden
    Institute of Biomedicine, Pharmacology, University of Helsinki, Finland
    Neuropharmacology 57:172-82. 2009
    ..Alternatively, functions of mGluR2 and mGluR3 may be redundant, resulting similar effects irrespective the receptor subtype being antagonized in vivo by LY341495...
  7. ncbi The caveolin scaffolding domain modifies 2-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor binding properties by inhibiting phospholipase A2 activity
    Sophie B Gaudreault
    Douglas Hospital Research Center, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec H4A 2B4, Canada
    J Biol Chem 279:356-62. 2004
    ..These results raised the possibility that caveolin-1, via the inhibition of cPLA2 enzymatic activity, may interfere with synaptic facilitation and long term potentiation formation in the hippocampus...
  8. ncbi Anxiolytic-like activity of the mGLU2/3 receptor agonist LY354740 in the elevated plus maze test is disrupted in metabotropic glutamate receptor 2 and 3 knock-out mice
    A M Linden
    Neuroscience Research Division, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Psychopharmacology (Berl) 179:284-91. 2005
    ..However, the lack of mGlu2 or mGlu3 receptor specific agonists has prevented in vivo characterization of individual functions of these two receptors in mediating the anxiolytic-like effects of LY354740...
  9. ncbi Effects of mGlu2 or mGlu3 receptor deletions on mGlu2/3 receptor agonist (LY354740)-induced brain c-Fos expression: specific roles for mGlu2 in the amygdala and subcortical nuclei, and mGlu3 in the hippocampus
    Anni Maija Linden
    Neuroscience Discovery, Lilly Research Laboratories, Central Nervous System Research, Eli Lilly and Company, Lilly Corporate Center, Drop Code 0510, Indianapolis, IN 46285, USA
    Neuropharmacology 51:213-28. 2006
    ....
  10. ncbi RNA editing in brain controls a determinant of ion flow in glutamate-gated channels
    B Sommer
    Laboratory for Molecular Neuroendocrinology, University of Heidelberg, Federal Republic of Germany
    Cell 67:11-9. 1991
    ..This process apparently edits subunit transcripts of the two glutamate receptor classes with different efficiency and selectivity...
  11. ncbi Early-onset epilepsy and postnatal lethality associated with an editing-deficient GluR-B allele in mice
    R Brusa
    Laboratory of Molecular Neuroendocrinology, University of Heidelberg, Germany
    Science 270:1677-80. 1995
    ..These mice developed seizures and died by 3 weeks of age, showing that GluR-B pre-mRNA editing is essential for brain function...
  12. ncbi Cloned glutamate receptors
    M Hollmann
    Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037
    Annu Rev Neurosci 17:31-108. 1994
  13. ncbi Enhanced LTP in mice deficient in the AMPA receptor GluR2
    Z Jia
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Neuron 17:945-56. 1996
    ..However, one subunit of the AMPARs, GluR2, is also known to control Ca2+ influx...
  14. ncbi Multiple behavioral anomalies in GluR2 mutant mice exhibiting enhanced LTP
    R Gerlai
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ont, Canada
    Behav Brain Res 95:37-45. 1998
    We have previously disrupted the ionotropic glutamate receptor type 2 gene (GluR2) using gene targeting in embryonic stem cells and generated mice which lacked the GluR2 gene product...
  15. pmc The AMPA receptor subunit GluR-B in its Q/R site-unedited form is not essential for brain development and function
    K Kask
    Department of Molecular Neuroscience, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 95:13777-82. 1998
    ..This constitutes proof in vivo that elevated calcium influx through AMPARs need not generate pathophysiological consequences...
  16. ncbi Neurological dysfunctions in mice expressing different levels of the Q/R site-unedited AMPAR subunit GluR-B
    D Feldmeyer
    Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Heidelberg, Germany
    Nat Neurosci 2:57-64. 1999
    ..Thus, changes in GluR-B gene expression and Q/R site editing can affect critical architectural and functional aspects of excitatory principal neurons...
  17. ncbi Impairment of AMPA receptor function in cerebellar granule cells of ataxic mutant mouse stargazer
    K Hashimoto
    Department of Physiology, Jichi Medical School, Minamikawachi Machi, Tochigi Ken 329 0498, Japan
    J Neurosci 19:6027-36. 1999
    ..These results suggest that the defect in MF to GC synaptic transmission is a major factor that causes the cerebellar dysfunction in the stg mutant mouse...
  18. ncbi Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2
    M Higuchi
    Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Heidelberg, Germany
    Nature 406:78-81. 2000
    ..We conclude that this transcript is the physiologically most important substrate of ADAR2...
  19. ncbi AMPA receptor-mediated miniature synaptic calcium transients in GluR2 null mice
    Sabrina Wang
    Kinsmen Laboratory, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia V6T 1Z3
    J Neurophysiol 88:29-40. 2002
    AMPA-type glutamate receptors are normally Ca(2+) impermeable due to the expression of the GluR2 receptor subunit...
  20. ncbi Requirement of AMPA receptor GluR2 phosphorylation for cerebellar long-term depression
    Hee Jung Chung
    Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 USA
    Science 300:1751-5. 2003
    ..LTD was absent in cultured cerebellar Purkinje cells from mutant mice lacking the AMPA receptor GluR2 subunit and could be rescued by transient transfection with the wild-type GluR2 subunit...
  21. ncbi Synaptic transmission and plasticity in the absence of AMPA glutamate receptor GluR2 and GluR3
    Yanghong Meng
    Program in Brain and Behavior, The Hospital for Sick Children, Toronto, Ontario, Canada
    Neuron 39:163-76. 2003
    The AMPA glutamate receptor (AMPAR) subunits GluR2 and GluR3 are thought to be important for synaptic targeting/stabilization of AMPARs and the expression of hippocampal long-term depression (LTD)...
  22. pmc A juvenile form of postsynaptic hippocampal long-term potentiation in mice deficient for the AMPA receptor subunit GluR-A
    Vidar Jensen
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, PO Box 1103 Blindern, N0317 Oslo, Norway
    J Physiol 553:843-56. 2003
    ..Our results show that in the developing hippocampus synaptic plasticity can be expressed by AMPA receptors lacking the GluR-A subunit...
  23. ncbi Aberrant formation of glutamate receptor complexes in hippocampal neurons of mice lacking the GluR2 AMPA receptor subunit
    Nathalie Sans
    Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892 8027, USA
    J Neurosci 23:9367-73. 2003
    ..To investigate the mechanism that neurons use to regulate the assembly of receptor subunits, we studied a GluR2 knock-out mouse...
  24. ncbi The AMPA receptor subunits GluR-A and GluR-B reciprocally modulate spinal synaptic plasticity and inflammatory pain
    Bettina Hartmann
    Institute for Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    Neuron 44:637-50. 2004
    ..Thus, AMPA receptors are not mere determinants of fast synaptic transmission underlying basal pain sensitivity as previously thought, but are critically involved in activity-dependent changes in synaptic processing of nociceptive inputs...
  25. ncbi A genetic switch for epilepsy in adult mice
    Heinz E Krestel
    Department of Molecular Neurobiology, Max Planck Institute for Medical Research, 69120 Heidelberg, Germany
    J Neurosci 24:10568-78. 2004
    ....
  26. ncbi Calcium-permeable AMPA receptor plasticity is mediated by subunit-specific interactions with PICK1 and NSF
    Stephanie M Gardner
    Department of Neuroscience, Johns Hopkins University, School of Medicine, Howard Hughes Medical Institute, 725 North Wolfe Street, Baltimore, Maryland 21205, USA
    Neuron 45:903-15. 2005
    ..Since the AMPA receptor GluR2 subunit confers calcium permeability, this plasticity is thought to occur through the dynamic exchange of synaptic ..
  27. ncbi Targeted in vivo mutations of the AMPA receptor subunit GluR2 and its interacting protein PICK1 eliminate cerebellar long-term depression
    Jordan P Steinberg
    Howard Hughes Medical Institute, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 49:845-60. 2006
    ..Phosphorylation of the AMPA receptor subunit GluR2 on serine-880 as well as interaction of GluR2 with PICK1 have been suggested to contribute to the endocytic ..
  28. ncbi Forebrain-specific glutamate receptor B deletion impairs spatial memory but not hippocampal field long-term potentiation
    Derya R Shimshek
    Department of Molecular Neurobiology, Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
    J Neurosci 26:8428-40. 2006
    We demonstrate the fundamental importance of glutamate receptor B (GluR-B) containing AMPA receptors in hippocampal function by analyzing mice with conditional GluR-B deficiency in postnatal forebrain principal neurons (GluR-B(deltaFb))...
  29. ncbi Conservation of glutamate receptor 2-containing AMPA receptors during long-term potentiation
    Hillel Adesnik
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 27:4598-602. 2007
    ..Here, we rigorously test these hypotheses and conclude that calcium-permeable AMPA receptors are not inserted during LTP nor does potentiation require ongoing activity to be maintained...
  30. pmc Activation of extrasynaptic NMDA receptors induces a PKC-dependent switch in AMPA receptor subtypes in mouse cerebellar stellate cells
    Lu Sun
    Department of Biology, 208 Mueller Lab, Penn State University, State College, PA 16802, USA
    J Physiol 583:537-53. 2007
    ..This extrasynaptic NMDAR-induced switch in synaptic AMPARs from GluR2-lacking (Ca(2+)-permeable) to GluR2-containing (Ca(2+)-impermeable) receptors requires the activation of protein ..
  31. ncbi Long-term potentiation in the hippocampal CA1 region does not require insertion and activation of GluR2-lacking AMPA receptors
    Erin E Gray
    Interdepartmental PhD Program for Neuroscience, David Geffen School of Medicine at UCLA, 53 231 Center for the Health Sciences, Los Angeles, CA 90095 1751, USA
    J Neurophysiol 98:2488-92. 2007
    ..Although it is widely accepted that the AMPA receptors at these synapses contain glutamate receptor type 2 (GluR2) subunits, recent findings suggest that LTP in hippocampal slices obtained from 2- to 3-wk-old rodents is ..
  32. ncbi Rapid synthesis and synaptic insertion of GluR2 for mGluR-LTD in the ventral tegmental area
    Manuel Mameli
    Department of Basic Neuroscience, Medical Faculty, University of Geneva, CH 1211 Geneva, Switzerland
    Science 317:530-3. 2007
    ..We show that mGluR-LTD is expressed by an exchange of GluR2-lacking AMPA receptors for GluR2-containing receptors with a lower single-channel conductance...
  33. ncbi Enhanced LTP of primary afferent neurotransmission in AMPA receptor GluR2-deficient mice
    Dong Ho Youn
    Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA
    Pain 136:158-67. 2008
    ..potentiation (LTP) and long-term depression (LTD) in the SDH, was investigated using mice deficient in AMPAR GluR2 subunit...
  34. pmc Synaptic AMPA receptor subunit trafficking is independent of the C terminus in the GluR2-lacking mouse
    Sandip Panicker
    Department of Cellular and Molecular Pharmacology and Physiology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 105:1032-7. 2008
    ..In hippocampal pyramidal cells, AMPA receptors are heteromeric receptors containing the GluR2 subunit and either GluR1 or GluR3...
  35. pmc Ca(2+) permeable AMPA receptor induced long-term potentiation requires PI3/MAP kinases but not Ca/CaM-dependent kinase II
    Suhail Asrar
    Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada
    PLoS ONE 4:e4339. 2009
    Ca(2+) influx via GluR2-lacking Ca(2+)-permeable AMPA glutamate receptors (CP-AMPARs) can trigger changes in synaptic efficacy in both interneurons and principle neurons, but the underlying mechanisms remain unknown...
  36. pmc Persistent inflammation induces GluR2 internalization via NMDA receptor-triggered PKC activation in dorsal horn neurons
    Jang Su Park
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 29:3206-19. 2009
    Spinal cord GluR2-lacking AMPA receptors (AMPARs) contribute to nociceptive hypersensitivity in persistent pain, but the molecular mechanisms underlying this event are not completely understood...
  37. pmc Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach
    Wei Lu
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 62:254-68. 2009
    ..This study provides a functional quantification of the subunit composition of AMPARs in the CNS and suggests novel roles for AMPAR subunits in receptor trafficking...
  38. pmc Opposing gradients of ribbon size and AMPA receptor expression underlie sensitivity differences among cochlear-nerve/hair-cell synapses
    Leslie D Liberman
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114 3096, USA
    J Neurosci 31:801-8. 2011
    ..imaging of mouse cochleas immunostained for CtBP2 (C-terminal binding protein 2, a major ribbon protein) and GluR2/3 (glutamate receptors 2 and 3)...
  39. pmc Synaptic profiles during neurite extension, refinement and retraction in the developing cochlea
    Lin Chien Huang
    Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Neural Dev 7:38. 2012
    ..The OHC connections are then selectively eliminated, leaving sparse innervation by type II afferent fibres, whilst the type I afferent synapses with IHCs are consolidated...
  40. ncbi The organization of the gene for the functionally dominant alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor subunit GluR-B
    M Kohler
    Laboratory of Molecular Neuroendocrinology, University of Heidelberg, Federal Republic of Germany
    J Biol Chem 269:17367-70. 1994
    ..The major GluR-B mRNAs in murine brain, 4 and 6 kilobase differ in the length of their 3'-untranslated region...
  41. ncbi The influence of glutamate receptor 2 expression on excitotoxicity in Glur2 null mutant mice
    K Iihara
    Toronto Western Hospital, University of Toronto, Toronto, Ontario M5T 2S8, Canada
    J Neurosci 21:2224-39. 2001
    ..Consequently, the mechanisms governing AMPAR-mediated excitotoxicity have been difficult to elucidate. The GluR2 subunit is of particular interest because it influences AMPAR pharmacology, Ca(2+) permeability, and AMPAR ..
  42. pmc Age-dependent requirement of AKAP150-anchored PKA and GluR2-lacking AMPA receptors in LTP
    Yuan Lu
    Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242 1109, USA
    EMBO J 26:4879-90. 2007
    ..It abolished hippocampal LTP in 7-12 but not 4-week-old mice. Inhibitors of PKA and of GluR2-lacking AMPA receptors blocked single tetanus LTP in hippocampal slices of 8 but not 4-week-old WT mice...
  43. ncbi Place-cell impairment in glutamate receptor 2 mutant mice
    Jun Yan
    Department of Physiology and Biophysics, University of Calgary, Calgary, T2N 4NI Canada
    J Neurosci 22:RC204. 2002
    ..We made glutamate receptor 2 (GluR2) null mutant mice that show enhanced non-Hebbian LTP in hippocampal CA1 neurons and impaired ..
  44. ncbi Loss of GLUR2 alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid receptor subunit differentially affects remaining synaptic glutamate receptors in cerebellum and cochlear nuclei
    Ronald S Petralia
    Laboratory of Neurochemistry, NIDCD NIH, 50 4142, 50 South Drive MSC 8027, Bethesda, MD 20892 8027, USA
    Eur J Neurosci 19:2017-29. 2004
    ..Most AMPA receptors are impermeable to calcium because they contain the GluR2 subunit...
  45. ncbi Loss of postsynaptic GABA(A) receptor clustering in gephyrin-deficient mice
    M Kneussel
    Department of Neurochemistry, Max Planck Institute for Brain Research, D 60528 Frankfurt Main, Germany
    J Neurosci 19:9289-97. 1999
    ..In addition, gephyrin may be important for efficient membrane insertion and/or metabolic stabilization of inhibitory receptors at developing postsynaptic sites...
  46. ncbi Impaired reproductive behavior by lack of GluR-B containing AMPA receptors but not of NMDA receptors in hypothalamic and septal neurons
    Derya R Shimshek
    Department of Molecular Neuroscience, Max Planck Institute for Medical Research, Heidelberg, Germany
    Mol Endocrinol 20:219-31. 2006
    ....
  47. pmc GABAA alpha6-containing receptors are selectively compromised in cerebellar granule cells of the ataxic mouse, stargazer
    Helen L Payne
    Centre for Integrative Neurosciences, School of Biological and Biomedical Sciences, Science Research Laboratories, Durham University, South Road, Durham DH1 3LE, United Kingdom
    J Biol Chem 282:29130-43. 2007
    ..We propose that some aspects of assembly, trafficking, targeting, and/or expression of extrasynaptic alpha6-containing GABA(A) receptors in cerebellar granule cells are selectively regulated by AMPA receptor-mediated signaling...
  48. pmc Endocytosis and recycling of AMPA receptors lacking GluR2/3
    Virginie Biou
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Proc Natl Acad Sci U S A 105:1038-43. 2008
    ..Here, we address the roles of GluR2 and GluR3 in controlling the recycling- and activity-dependent endocytosis of AMPARs by using cultured hippocampal ..
  49. doi Proteomics analysis of immuno-precipitated synaptic protein complexes
    P Klemmer
    Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, VU University Amsterdam, De Boelelaan 1085, 1081 Amsterdam, The Netherlands
    J Proteomics 72:82-90. 2009
    ..e., the glutamate receptor (GluR2), scaffolding proteins (PSD-95 and CASK), voltage gated potassium (KCNQ2 and Kv4...
  50. pmc HNK-1 glyco-epitope regulates the stability of the glutamate receptor subunit GluR2 on the neuronal cell surface
    Ippei Morita
    Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    J Biol Chem 284:30209-17. 2009
    ..study, we identified an alpha-amino-3-hydroxy-5-methylisoxazole propionate (AMPA)-type glutamate receptor subunit, GluR2, which directly contributes to excitatory synaptic transmission and synaptic plasticity, as a novel HNK-1 carrier ..
  51. doi Shox2 function couples neural, muscular and skeletal development in the proximal forelimb
    Lori Vickerman
    Department of Biological Sciences, University of Calgary, Calgary, AB, Canada
    Dev Biol 350:323-36. 2011
    ..These data demonstrate that Shox2 is required for normal skeletal, neural and muscular development in the forelimb at a similar early developmental stage in each tissue...
  52. doi Conditional deletion of NRSF in forebrain neurons accelerates epileptogenesis in the kindling model
    Xiao Ling Hu
    Institute of Neuroscience, Chinese Academy of Sciences, Shanghai 200031, PR China
    Cereb Cortex 21:2158-65. 2011
    ..Furthermore, the derepression of BDNF was associated by activation of PLCγ and PI(3)K signaling pathways. These findings indicate that NRSF functions as an intrinsic repressor of limbic epileptogenesis...
  53. pmc Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3
    Xiaoming Wang
    Department of Pediatrics, Duke University School of Medicine, Durham, NC 27710, USA
    Hum Mol Genet 20:3093-108. 2011
    ..We conclude that loss of major Shank3 species produces biochemical, cellular and morphological changes, leading to behavioral abnormalities in mice that bear similarities to human ASD patients with SHANK3 mutations...
  54. pmc GluA2-lacking AMPA receptors in hippocampal CA1 cell synapses: evidence from gene-targeted mice
    Andrei Rozov
    Division of Neuroscience, Medical Research Institute Ninewells Hospital and Medical School, Dundee University Dundee, UK
    Front Mol Neurosci 5:22. 2012
    The GluA2 subunit in heteromeric alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor channels restricts Ca(2+) permeability and block by polyamines, rendering linear the current-voltage relationship of these ..
  55. doi High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes
    Jochen Schwenk
    Institute of Physiology, University of Freiburg, Hermann Herder Str 7, 79104 Freiburg, Germany
    Neuron 74:621-33. 2012
    ..6 and 1 MDa. The additional constituents change the gating properties of AMPARs and provide links to the protein dynamics fundamental for the complex role of AMPARs in formation and operation of glutamatergic synapses...
  56. pmc O-GlcNAcylation of AMPA receptor GluA2 is associated with a novel form of long-term depression at hippocampal synapses
    Erica W Taylor
    Department of Cell, Developmental and Integrative Biology, Department of Neurology, Department of Psychiatry and Behavioral Neurobiology, and Division of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294
    J Neurosci 34:10-21. 2014
    Serine phosphorylation of AMPA receptor (AMPAR) subunits GluA1 and GluA2 modulates AMPAR trafficking during long-term changes in strength of hippocampal excitatory transmission required for normal learning and memory...
  57. pmc FXR1P limits long-term memory, long-lasting synaptic potentiation, and de novo GluA2 translation
    Denise Cook
    Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, QC H3G 1A4, Canada
    Cell Rep 9:1402-16. 2014
    ..enhances long-term storage of spatial memories, hippocampal late-phase long-term potentiation (L-LTP), and de novo GluA2 synthesis...
  58. pmc Alterations in Hippocampal Oxidative Stress, Expression of AMPA Receptor GluR2 Subunit and Associated Spatial Memory Loss by Bacopa monnieri Extract (CDRI-08) in Streptozotocin-Induced Diabetes Mellitus Type 2 Mice
    Surya P Pandey
    Biochemistry and Molecular Biology Lab, Centre of Advanced Study in Zoology, Banaras Hindu University, Varanasi, 221005, Uttar Pradesh, India
    PLoS ONE 10:e0131862. 2015
    ..mice and this is correlated with a significant decline in oxidative stress and up regulation of the AMPA receptor GluR2 subunit gene expression in the hippocampus...
  59. ncbi Gamma-hydroxybutyric acid-induced absence seizures in GluR2 null mutant mice
    R Q Hu
    Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    Brain Res 897:27-35. 2001
    In this electrophysiological study, we examined the susceptibility of GluR2 mutant null mice to absence seizures in comparison with wild-type controls...
  60. pmc DNA methylation mediates persistent epileptiform activity in vitro and in vivo
    Ziv M Machnes
    Department of Pharmacology and Therapeutics McGill University, McGill University, Montreal, Quebec, Canada
    PLoS ONE 8:e76299. 2013
    ..We analyzed changes in the gria2 gene, which encodes for the GluA2 subunit of the ionotropic glutamate, alpha-amino-3-hydroxy-5-methyl-4-isoxazole ..
  61. doi Extensive cryptic splicing upon loss of RBM17 and TDP43 in neurodegeneration models
    Qiumin Tan
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Hum Mol Genet . 2016
    ..We propose that repression of cryptic splicing by RBPs is critical for neuronal health and survival. CrypSplice is available at www.liuzlab.org/CrypSplice...
  62. ncbi Glycine receptor beta-subunit gene mutation in spastic mouse associated with LINE-1 element insertion
    S F Kingsmore
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
    Nat Genet 7:136-41. 1994
    ..These results provide evidence that Glrb is necessary for postsynaptic expression of glycine receptor complexes, and suggest Glrb as a candidate gene for inherited myoclonus in other species...
  63. pmc Transmembrane and ubiquitin-like domain-containing protein 1 (Tmub1/HOPS) facilitates surface expression of GluR2-containing AMPA receptors
    Hyunjeong Yang
    Department of Biological Information, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan
    PLoS ONE 3:e2809. 2008
    ..in the brain and which exists in a synaptosomal membrane fraction, facilitates the recycling of the AMPAR subunit GluR2 to the cell surface...
  64. pmc MicroRNA-223 is neuroprotective by targeting glutamate receptors
    Maged M Harraz
    Neuroregeneration Program, Institute for Cell Engineering, Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 109:18962-7. 2012
    ..the response to neuronal injury by regulating the functional expression of the glutamate receptor subunits GluR2 and NR2B in brain...
  65. doi Expression, subunit composition, and function of AMPA-type glutamate receptors are changed in activated microglia; possible contribution of GluA2 (GluR-B)-deficiency under pathological conditions
    Kaoru Beppu
    Laboratory of Pathophysiology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Glia 61:881-91. 2013
    ..of glutamate (Glu) receptors (AMPAR), which are highly Ca(2+) impermeable due to the expression of GluA2. However, the functional importance of AMPAR in microglia remains to be investigated, especially under ..
  66. ncbi RNA editing of the glutamate receptor subunits GluR2 and GluR6 in human brain tissue
    W Paschen
    Department of Psychiatry and Neuroscience, Johns Hopkins University, School of Medicine, Baltimore
    J Neurochem 63:1596-602. 1994
    Editing of mRNA in the coding region of the second transmembrane domain of glutamate receptor subunits GluR2, GluR5, and GluR6 involves a change of the base A in genomic DNA to the base G in mRNA as described in rat brain...
  67. ncbi AMPA receptor subunits expressed by single astrocytes in the juvenile mouse hippocampus
    G Seifert
    Institute of Physiology, Department of Neurophysiology, Friedrich Schiller University Jena, Germany
    Brain Res Mol Brain Res 47:286-94. 1997
    ..Our results suggest the expression of a heteromeric subunit architecture. In all cells, the GluR2 subunit was present, which is known to confer a low Ca2+ permeability to the receptor complex...
  68. pmc Allosteric modulation of AMPA-type glutamate receptors increases activity of the promoter for the neural cell adhesion molecule, N-CAM
    B D Holst
    Department of Neurobiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 95:2597-602. 1998
    ....
  69. ncbi Glutamate receptors: brain function and signal transduction
    S Nakanishi
    Department of Biological Sciences, Kyoto University Faculty of Medicine, Yoshida, Sakyo ku, Kyoto 606, Japan
    Brain Res Brain Res Rev 26:230-5. 1998
    ..Thus, the two closely related mGluR subtypes mediate diverging intracellular signaling in glutamate transmission...
  70. ncbi The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn
    T Hayashi
    Department of Oncology, Institute of Medical Science, The University of Tokyo, Japan
    Nature 397:72-6. 1999
    ..Thus, AMPA receptors generate intracellular signals from the cell surface to the nucleus through the Lyn-MAPK pathway, which may contribute to synaptic plasticity by regulating the expression of BDNF...
  71. ncbi Use-dependent AMPA receptor block in mice lacking GluR2 suggests postsynaptic site for LTP expression
    Z F Mainen
    Cold Spring Harbor Laboratory, New York 11724, USA
    Nat Neurosci 1:579-86. 1998
    ..To test these models directly, we studied a GluR2 knockout mouse in which AMPA receptor transmission is rendered sensitive to a use-dependent block by polyamine ..
  72. pmc A phylogenetic analysis reveals an unusual sequence conservation within introns involved in RNA editing
    P J Aruscavage
    Department of Biochemistry Howard Hughes Medical Institute, University of Utah, Salt Lake City 84132, USA
    RNA 6:257-69. 2000
    ..The approximately 600-nt intron 13 of gluR-C was particularly remarkable, showing >94% nucleotide identity between human and chicken, organisms estimated to have diverged 310 million years ago...
  73. ncbi Blockade of AMPA receptors and volatile anesthetics: reduced anesthetic requirements in GluR2 null mutant mice for loss of the righting reflex and antinociception but not minimum alveolar concentration
    D T Joo
    Department of Anesthesia, University of Toronto, Ontario, Canada
    Anesthesiology 94:478-88. 2001
    ..AMPA receptors lacking the GluR2 subunit are resistant to blockade by barbiturates in vitro...
  74. ncbi Evidence that GRIP, a PDZ-domain protein which is expressed in the embryonic forebrain, co-activates transcription with DLX homeodomain proteins
    G Yu
    Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry, 401 Parnassus Avenue, University of California at San Francisco, CA 94143 0984, USA
    Brain Res Dev Brain Res 130:217-30. 2001
    ..Furthermore, these results suggest a link between glutamate receptors, PDZ proteins and the DLX transcription factors, all of which are co-expressed in the developing basal ganglia...
  75. ncbi Distribution of alpha-amino-3-hydroxy-5-methyl-4 isoazolepropionic acid and N-methyl-D-aspartate receptor subunits in the vestibular and spiral ganglia of the mouse during early development
    Julien Puyal
    INSERM U 432, Universite de Montpellier II, UM 2, CC 89, Place Bataillon, 34095 Montpellier Cedex 5, France
    Brain Res Dev Brain Res 139:51-7. 2002
    ..distribution of the glutamate receptor subunits, alpha-amino-3-hydroxy-5-methyl-4 isoazolepropionic acid (AMPA) GluR2 and GluR2/R3, and N-methyl-D-aspartate (NMDA) NR1, and the timing of their appearance during early development of ..
  76. ncbi Heteromer formation of delta2 glutamate receptors with AMPA or kainate receptors
    Kazuhisa Kohda
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Brain Res Mol Brain Res 110:27-37. 2003
    ..receptors were partially co-immunoprecipitated from cerebellar synaptosomal fractions by antibodies against GluR2 or KA2...
  77. ncbi BDNF regulates spontaneous correlated activity at early developmental stages by increasing synaptogenesis and expression of the K+/Cl- co-transporter KCC2
    Fernando Aguado
    Department of Cell Biology Faculty of Biology, and Barcelona Science Park, University of Barcelona, Barcelona 08028, Spain
    Development 130:1267-80. 2003
    ..Given that BDNF itself is regulated by neuronal activity, we suggest that BDNF acts as a homeostatic factor controlling the emergence, complexity and networking properties of spontaneous networks...
  78. ncbi Microtubule-associated protein light chain 2 is a stargazin-AMPA receptor complex-interacting protein in vivo
    Jane H Ives
    School of Biological and Biomedical Sciences, Science Research Laboratories, University of Durham, South Road, Durham DH1 3LE, United Kingdom
    J Biol Chem 279:31002-9. 2004
    ..soluble cerebellar extracts revealed that LC2 is pulled down not only by anti-stargazin antibodies but also anti-GluR2 antibodies suggesting that stargazin and AMPA receptor subunits associate with LC2...
  79. ncbi Effects of deletion of gria1 or gria2 genes encoding glutamatergic AMPA-receptor subunits on place preference conditioning in mice
    Andy N Mead
    Department of Psychology, School of Life Sciences, University of Sussex, BN1 9QG, UK
    Psychopharmacology (Berl) 179:164-71. 2005
    ..Critically, this classical conditioning procedure requires the formation of associations between a rewarding stimulus and environmental cues, and the ability of these cues to direct subsequent behaviour...
  80. pmc Molecular constituents of neuronal AMPA receptors
    Yuko Fukata
    Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 169:399-404. 2005
    ..facilitate purification of neuronal AMPAR complexes, we generated a transgenic mouse expressing an epitope-tagged GluR2 subunit of AMPARs...
  81. ncbi GluR2 deficiency accelerates motor neuron degeneration in a mouse model of amyotrophic lateral sclerosis
    Philip Van Damme
    Laboratory of Neurobiology, K U Leuven, Campus Gasthuisberg, Leuven, Belgium
    J Neuropathol Exp Neurol 64:605-12. 2005
    ..e. GluR2-lacking) AMPA receptors...
  82. ncbi Differential regulation of AMPA receptor subunit trafficking by palmitoylation of two distinct sites
    Takashi Hayashi
    Howard Hughes Medical Institute, Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA
    Neuron 47:709-23. 2005
    ..These data suggest that regulated palmitoylation of AMPA receptor subunits modulates receptor trafficking and may be important for synaptic plasticity...
  83. ncbi Long-term depression requires postsynaptic AMPA GluR2 receptor in adult mouse cingulate cortex
    Hiroki Toyoda
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Science Building, 1 King s College Circle, Toronto, Ontario, Canada
    J Cell Physiol 211:336-43. 2007
    ..Here, we used integrative genetic, pharmacological and electrophysiological approaches to demonstrate that AMPA GluR2, but not GluR3, subunit is critical for cingulate LTD...
  84. pmc Group II metabotropic glutamate receptors inhibit glutamate release at thalamocortical synapses in the developing somatosensory cortex
    Z Mateo
    Department of Physiology, Pharmacology and Toxicology, Ponce School of Medicine, PO Box 7004, Ponce, Puerto Rico 00732
    Neuroscience 146:1062-72. 2007
    ..This inhibition provides a feedback mechanism for preventing excessive excitation of cortical neurons that could play a role in the plasticity and refinement of thalamocortical connections during this early developmental period...
  85. ncbi GluR2-free alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors intensify demyelination in experimental autoimmune encephalomyelitis
    Peter Bannerman
    UC Davis School of Medicine, Shriners Hospital, Sacramento, California 95817, USA
    J Neurochem 102:1064-70. 2007
    We adopted a genetic approach to test the importance of edited GluR2-free, Ca(2+)-permeable, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors in the pathophysiology of experimental autoimmune encephalomyelitis, an ..
  86. ncbi Auditory sensitivity regulation via rapid changes in expression of surface AMPA receptors
    Zhiqiang Chen
    Department of Otology and Laryngology, Harvard Medical School, 243 Charles Street, Boston, Massachusetts 02114, USA
    Nat Neurosci 10:1238-40. 2007
    ..Thus we show that AMPA receptor cycling is important for optimizing synaptic transfer at one of the most exacting synapses in the body...
  87. ncbi GluR2 expressed by glial fibrillary acidic protein promoter decreases the number of neurons
    Keisuke Tsuzuki
    Department of Neurophysiology, Gunma University Graduate School of Medicine, Gunma 371 8511, Japan
    Front Biosci 13:2784-96. 2008
    ..b>GluR2, a subunit of AMPA receptors, is the determinant of Ca2+-permeability and surface expression of the receptors...
  88. pmc Parkin occurs in a stable, non-covalent, approximately 110-kDa complex in brain
    Cindy Van Humbeeck
    Department of Neurosciences, Division of Experimental Neurology, University of Leuven, Leuven, Belgium
    Eur J Neurosci 27:284-93. 2008
    ..These data demonstrate that parkin oligomerizes into a stable, non-covalent, heteromeric complex in vivo, and suggest that parkin may have as yet unidentified stable binding partners...
  89. pmc A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling
    Kei Hori
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Genes Dev 22:166-78. 2008
    ....
  90. pmc Voluntary oral nicotine intake in mice down-regulates GluR2 but does not modulate depression-like behaviors
    Patricia Vieyra-Reyes
    Yale University, Department of Psychiatry, 34 Park Street, New Haven, CT 06508, USA
    Neurosci Lett 434:18-22. 2008
    ..were few behavioral changes in mice subjected to chronic nicotine exposure, but there was a marked regulation of GluR2 in the mesolimbic system...
  91. pmc Altered presymptomatic AMPA and cannabinoid receptor trafficking in motor neurons of ALS model mice: implications for excitotoxicity
    Pingwei Zhao
    Forbes Norris ALS MDA Research Center, California Pacific Medical Center Research Institute, 475 Brannan St, Suite 220, San Francisco, CA 94107, USA
    Eur J Neurosci 27:572-9. 2008
    ..subclasses of AMPARs [as determined by the presence of the subunits glutamate receptor 1 (GluR1) or glutamate receptor 2 (GluR2)] and CB1 in spinal cord motor neurons during disease progression in a G93ASOD1 mouse model of ALS...
  92. pmc Identification of a serotonin/glutamate receptor complex implicated in psychosis
    Javier Gonzalez-Maeso
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nature 452:93-7. 2008
    ..These regulatory changes indicate that the 2AR-mGluR2 complex may be involved in the altered cortical processes of schizophrenia, and this complex is therefore a promising new target for the treatment of psychosis...
  93. pmc Vulnerability of white matter towards antenatal hypoxia is linked to a species-dependent regulation of glutamate receptor subunits
    Romain H Fontaine
    Institut National de la Sante et de la Recherche Medicale, AVENIR RO5230HS, Paris, France
    Proc Natl Acad Sci U S A 105:16779-84. 2008
    ..Gestational hypoxia may regulate the expression of specific glutamate-receptor subunits in fetal mice but not in fetal rats. Therefore, genetic factors may influence the susceptibility of rodents to WMD...
  94. pmc Characteristics and functions of {alpha}-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors expressed in mouse pancreatic {alpha}-cells
    Jung Hwa Cho
    Department of Physiology and Biophysics, University of Washington School of Medicine, G 424 Health Science Building, Box 357290, Seattle, Washington 98195 7290, USA
    Endocrinology 151:1541-50. 2010
    ..In conclusion, iGluRs expressed in mouse alpha-cells resemble the low Ca(2+)-permeable AMPA receptor in brain and can stimulate exocytosis...
  95. doi YB-1 binds to GluR2 mRNA and CaM1 mRNA in the brain and regulates their translational levels in an activity-dependent manner
    Toru Tanaka
    Research Unit of Biochemistry, School of Pharmacy, Nihon University, Funabashi, Chiba, Japan
    Cell Mol Neurobiol 30:1089-100. 2010
    ..In this study we found that YB-1 interacted with the mRNAs for glutamate receptor subunit 2 (GluR2) and calmodulin1 (CaM1) in both brain and NG108-15 cells...
  96. doi Induced loss of ADAR2 engenders slow death of motor neurons from Q/R site-unedited GluR2
    Takuto Hideyama
    Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Neurosci 30:11917-25. 2010
    b>GluR2 is a subunit of the AMPA receptor, and the adenosine for the Q/R site of its pre-mRNA is converted to inosine (A-to-I conversion) by the enzyme called adenosine deaminase acting on RNA 2 (ADAR2)...
  97. doi GluA2 (GluR2) regulates metabotropic glutamate receptor-dependent long-term depression through N-cadherin-dependent and cofilin-mediated actin reorganization
    Zikai Zhou
    Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    J Neurosci 31:819-33. 2011
    The GluA2 (GluR2) subunit is critical for the regulation of AMPA receptor properties and synaptic plasticity, but the underlying mechanisms remain unclear...
  98. doi Glutamate receptor δ2 is essential for input pathway-dependent regulation of synaptic AMPAR contents in cerebellar Purkinje cells
    Miwako Yamasaki
    Department of Anatomy, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    J Neurosci 31:3362-74. 2011
    ..In both control and GluRδ2-KO mice, GluA1-3 were localized at PF and CF synapses in PCs, while GluA2-4 were at PF synapses in interneurons...
  99. pmc Pin1 and WWP2 regulate GluR2 Q/R site RNA editing by ADAR2 with opposing effects
    Roberto Marcucci
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK
    EMBO J 30:4211-22. 2011
    ADAR2 catalyses the deamination of adenosine to inosine at the GluR2 Q/R site in the pre-mRNA encoding the critical subunit of AMPA receptors...