Genomes and Genes
Gene Symbol: Gt(ROSA)26Sor
Description: gene trap ROSA 26, Philippe Soriano
Alias: AV258896, Gtrgeo26, Gtrosa26, R26, ROSA26
Publications167 found, 100 shown here
- Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locusS Srinivas
Department of Genetics and Development, Columbia University, New York, USA
BMC Dev Biol 1:4. 2001....
- Identification of stem cells in small intestine and colon by marker gene Lgr5Nick Barker
Hubrecht Institute, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
Nature 449:1003-7. 2007..Using an inducible Cre knock-in allele and the Rosa26-lacZ reporter strain, lineage-tracing experiments were performed in adult mice...
- Generalized lacZ expression with the ROSA26 Cre reporter strainP Soriano
Nat Genet 21:70-1. 1999
- Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent proteinNathan C Shaner
Nat Biotechnol 22:1567-72. 2004..Three monomers with distinguishable hues from yellow-orange to red-orange have higher quantum efficiencies...
- Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouseShigemi Hayashi
Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
Dev Biol 244:305-18. 2002..This inducible Cre system will be a broadly useful tool to modulate gene activity in mouse embryos, adults, and culture systems where temporal control is an important consideration...
- A global double-fluorescent Cre reporter mouseMandar Deepak Muzumdar
Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA
Genesis 45:593-605. 2007..In addition to serving as a global Cre reporter, the mT/mG mouse may also be used as a tool for lineage tracing, transplantation studies, and analysis of cell morphology in vivo...
- The Lin28/let-7 axis regulates glucose metabolismHao Zhu
Stem Cell Transplantation Program, Division of Pediatric Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, MA, USA
Cell 147:81-94. 2011..These data establish the Lin28/let-7 pathway as a central regulator of mammalian glucose metabolism...
- A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortexHiroki Taniguchi
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
Neuron 71:995-1013. 2011..As such, this approach will accelerate the study of GABAergic circuits throughout the mammalian brain...
- Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heartChen Leng Cai
Institute of Molecular Medicine, Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
Dev Cell 5:877-89. 2003..Our results have implications for the development of specific cardiac lineages, left-right asymmetry, cardiac evolution, and isolation of cardiac progenitor cells...
- Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineagesKarl Ludwig Laugwitz
Institute of Molecular Medicine, University of California, San Diego, School of Medicine, La Jolla, California 92093, USA
Nature 433:647-53. 2005..The discovery of native cardioblasts represents a genetically based system to identify steps in cardiac cell lineage formation and maturation in development and disease...
- Fate of the mammalian cardiac neural crestX Jiang
Departments of Biological Sciences and Cell and Neurobiology, Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, IGM 240, Los Angeles, CA 90033, USA
Development 127:1607-16. 2000....
- Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissuesKonrad Hochedlinger
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
Cell 121:465-77. 2005..These data show that certain adult progenitors remain competent to interpret key embryonic signals and support the notion that progenitor cells are a driving force in tumorigenesis...
- Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineageJessica A Gorski
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
J Neurosci 22:6309-14. 2002..Structures that are located near the basal ganglia (e.g., the amygdala and endopiriform nuclei) are not uniformly derived from Emx1-expressing cells...
- Tissue-specific and inducible Cre-mediated recombination in the gut epitheliumFatima el Marjou
Morphogenesis and intracellular signalling, Institut Curie CNRS, Paris, France
Genesis 39:186-93. 2004..The villin-Cre and villin-Cre-ERT2 mice provide valuable tools for studies of cell lineage allocation and gene function in the developing and adult intestine...
- Faithful activation of an extra-bright red fluorescent protein in "knock-in" Cre-reporter mice ideally suited for lineage tracing studiesHervé Luche
Institute of Immunology, University Clinics Ulm, Ulm, Germany
Eur J Immunol 37:43-53. 2007..red fluorescent protein (tdRFP) with advanced spectral and biological properties into the ubiquitously expressed ROSA26 locus of C57BL/6-ES cells, we have generated a novel inbred Cre-reporter mouse with several unique characteristics...
- Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identitiesBrian D Harfe
Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610, USA
Cell 118:517-28. 2004..Genetic studies of the effects of limiting accessibility of Shh within the limb support this model, in which the effect of the Shh morphogen is dictated by a temporal as well as a spatial gradient...
- Genetic fate mapping reveals that the caudal ganglionic eminence produces a large and diverse population of superficial cortical interneuronsGoichi Miyoshi
Smilow Neuroscience Program and the Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
J Neurosci 30:1582-94. 2010..Thus, in conjunction with previous studies, we have now determined the spatial and temporal origins of the vast majority of cortical interneuron subtypes...
- Transgenic mice with hematopoietic and lymphoid specific expression of CreJasper de Boer
Department of Molecular Immunology, National Institute for Medical Research, The Ridgeway, London, GB
Eur J Immunol 33:314-25. 2003..Both of these Cre-transgenic lines will be useful in generating tissue-specific gene deletions within all the cells of hematopoietic or lymphoid tissues...
- Reprogramming of T cells to natural killer-like cells upon Bcl11b deletionPeng Li
Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
Science 329:85-9. 2010..Therefore, ITNKs may represent a new cell source for cell-based therapies...
- The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesisRui Benedito
Cancer Research UK London Research Institute, Vascular Development Laboratory, London, UK
Cell 137:1124-35. 2009....
- Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brainBarton Wicksteed
Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Chicago, Chicago, llinois, USA
Diabetes 59:3090-8. 2010..The objective of this study was to examine whether mouse transgenic Cre lines, used to mediate β-cell- or pancreas-specific recombination, also drive Cre expression in the brain...
- Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestineBlair B Madison
Department of Cell and Developmental Biology, The University of Michigan Medical School, Ann Arbor, Michigan 48109 0616, USA
J Biol Chem 277:33275-83. 2002....
- Leptin targets in the mouse brainMichael M Scott
Division of Hypothalamic Research, Departments of Internal Medicine and Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Comp Neurol 514:518-32. 2009..Thus, we provide data supporting the use of the LepRb-IRES-Cre line for the assessment of the anatomic and functional characteristics of neurons expressing leptin receptor...
- Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivoY Y Kisanuki
Department of Molecular Genetics, Howard Hughes Medical Institute, Dallas, Texas, 75390 9050, USA
Dev Biol 230:230-42. 2001..Tie2-Cre transgenic mice are a new genetic tool for the analyses of endothelial cell-lineage and endothelial cell-specific gene targeting...
- The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitorsYoshiya Kawaguchi
Vanderbilt Developmental Biology Program, Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, Tennessee 37232 2175, USA
Nat Genet 32:128-34. 2002..These experiments provide evidence that Ptf1a expression is specifically connected to the acquisition of pancreatic fate by undifferentiated foregut endoderm...
- Aberrant T cell differentiation in the absence of DicerStefan A Muljo
The CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
J Exp Med 202:261-9. 2005..Independent of their proliferation defect, Dicer-deficient helper T cells preferentially expressed interferon-gamma, the hallmark effector cytokine of the Th1 lineage...
- A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administrationThorsten Buch
Laboratory for Molecular Immunology, Institute for Genetics, University of Cologne, D 50931 Cologne, Germany
Nat Methods 2:419-26. 2005..Notably, we show that the developing DT-specific antibody response is weak and not neutralizing, and thus does not impede the efficacy of DT. Our results validate the use of iDTR mice as a tool for cell ablation in vivo...
- Testing gene function early in the B cell lineage in mb1-cre miceE Hobeika
Max Planck Institute of Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
Proc Natl Acad Sci U S A 103:13789-94. 2006..The availability of a mouse line with efficient cre-mediated recombination at an early developmental stage in the B lineage provides an opportunity to study the role of various genes specifically in B cell development and function...
- The cell and molecular basis of mechanical, cold, and inflammatory painBjarke Abrahamsen
Molecular Nociception Group, University College London UCL, Gower Street, London, WC1E 6BT, UK
Science 321:702-5. 2008..These data demonstrate that Na(v)1.8-expressing neurons are essential for mechanical, cold, and inflammatory pain but not for neuropathic pain or heat sensing...
- Basal cells as stem cells of the mouse trachea and human airway epitheliumJason R Rock
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 106:12771-5. 2009..Like those from the mouse trachea, human airway basal cells both self-renew and generate luminal daughters in the sphere-forming assay...
- Cell tracing shows the contribution of the yolk sac to adult haematopoiesisIgor M Samokhvalov
Laboratory for Stem Cell Biology, Center for Developmental Biology, RIKEN Kobe, Kobe 650 0047, Japan
Nature 446:1056-61. 2007..We observed virtually no contribution of the labelled cells towards the yolk sac vasculature, indicating early segregation of endothelial and haematopoietic lineages...
- Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleenMichele L Caton
Department of Microbiology, Columbia University Medical Center, New York, NY 10032, USA
J Exp Med 204:1653-64. 2007..Thus, canonical Notch-RBP-J signaling controls the maintenance of CD8(-) DCs in the splenic MZ, revealing an unexpected role of the Notch pathway in the innate immune system...
- Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heartBin Zhou
Harvard Stem Cell Institute and Department of Cardiology, Children s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
Nature 454:109-13. 2008..These results identify Wt1(+) epicardial cells as previously unrecognized cardiomyocyte progenitors, and lay the foundation for future efforts to harness the cardiogenic potential of these progenitors for cardiac regeneration and repair...
- Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinomaEtienne Meylan
Koch Institute for Integrative Cancer Research, and Department of Biology, and Howard Hughes Medical Institute, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
Nature 462:104-7. 2009..These findings also provide support for the development of NF-kappaB inhibitory drugs as targeted therapies for the treatment of patients with defined mutations in Kras and p53...
- Leptin action via neurotensin neurons controls orexin, the mesolimbic dopamine system and energy balanceGina M Leinninger
Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
Cell Metab 14:313-23. 2011..Thus, LHA LepRb(Nts) neurons mediate physiologic leptin action on OX neurons and the mesolimbic DA system, and contribute importantly to the control of energy balance...
- Corneal avascularity is due to soluble VEGF receptor-1Balamurali K Ambati
Department of Ophthalmology, Medical College of Georgia and Augusta Veterans Affairs Medical Center, Augusta, Georgia 30907, USA
Nature 443:993-7. 2006....
- TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epitheliaNeil A Bhowmick
Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Science 303:848-51. 2004..Thus, TGF-beta signaling in fibroblasts modulates the growth and oncogenic potential of adjacent epithelia in selected tissues...
- Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous systemJean Livet
Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA
Nature 450:56-62. 2007..The ability of the Brainbow system to label uniquely many individual cells within a population may facilitate the analysis of neuronal circuitry on a large scale...
- Multiple layers of B cell memory with different effector functionsIsmail Dogan
Institut National de la Santé et de la Recherche Médicale U783 Développement du système immunitaire, Universite Paris Descartes, Faculte de Medecine, Site Necker Enfants Malades, Paris, France
Nat Immunol 10:1292-9. 2009..This model, in which B cell memory appears in several layers with different functions, reconciles previous conflicting propositions...
- Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birthMyriam Solar
Genomic Programming of Beta Cells Laboratory, Institut d Investigacions Biomediques August Pi i Sunyer, 08036 Barcelona, Spain
Dev Cell 17:849-60. 2009..Thus, once the ductal epithelium differentiates it has a restricted plasticity, even under regenerative settings...
- IL-7 and IL-15 independently program the differentiation of intestinal CD3-NKp46+ cell subsets from Id2-dependent precursorsNaoko Satoh-Takayama
Cytokines and Lymphoid Development Unit, Institut Pasteur, 75724 Paris, France
J Exp Med 207:273-80. 2010..1(-)Rorc(+) cells are not canonical NK cell precursors. These studies highlight the independent cytokine regulation of functionally diverse intestinal NKp46(+) cell subsets...
- Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehogEric Dessaud
Developmental Neurobiology, MRC National Institute for Medical Research, London, United Kingdom
PLoS Biol 8:e1000382. 2010..This suggests an alternative to conventional models of morphogen action that rely solely on the level of signalling...
- Integrin α6β4 identifies an adult distal lung epithelial population with regenerative potential in miceHarold A Chapman
Department of Medicine, Cardiovascular Research Institute, and Lung Biology Center, UCSF, San Francisco, California 94143, USA
J Clin Invest 121:2855-62. 2011....
- PI3K integrates the action of insulin and leptin on hypothalamic neuronsAllison Wanting Xu
Department of Genetics, Stanford University School of Medicine, Stanford, California, USA
J Clin Invest 115:951-8. 2005..These results suggest a new view of hypothalamic circuitry, in which the effects of leptin and insulin are integrated by anorexigenic but not by orexigenic neurons...
- Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediatesAnna L Means
Department of Surgery, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Development 132:3767-76. 2005....
- Math1 is expressed in temporally discrete pools of cerebellar rhombic-lip neural progenitorsRob Machold
Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, New York 10016, USA
Neuron 48:17-24. 2005..Thus, we demonstrate that the cerebellar rhombic lip gives rise to multiple cell types within rhombomere 1...
- Toxicity of ligand-dependent Cre recombinases and generation of a conditional Cre deleter mouse allowing mosaic recombination in peripheral tissuesDorothe Hameyer
Institute of Toxicology Mouse Genetics, Johannes Gutenberg Universitat Mainz, Mainz, Germany
Physiol Genomics 31:32-41. 2007..To compare ligand-dependent Cre recombinases, different Cre estrogen receptor fusions were introduced into the ROSA26 locus of embryonic stem (ES) cells and assayed for genotoxicity and recombination efficiency...
- Induction of an IL7-R(+)c-Kit(hi) myelolymphoid progenitor critically dependent on IFN-gamma signaling during acute malariaNikolai N Belyaev
Division of Molecular Immunology, Medical Research Council National Institute for Medical Research, London, UK
Nat Immunol 11:477-85. 2010..Thus, IFN-gamma is a key modulator of hematopoiesis and innate and adaptive immunity during acute malaria infection...
- FGF10 controls the patterning of the tracheal cartilage rings via ShhFrederic G Sala
Developmental Biology and Regenerative Medicine Program, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
Development 138:273-82. 2011..We propose that disturbed balances of Fgf10 and Shh may explain a subset of human tracheomalacia without tracheo-esophageal fistula or tracheal atresia...
- Context-specific α- to-β-cell reprogramming by forced Pdx1 expressionYu Ping Yang
Vanderbilt University Program in Developmental Biology, Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
Genes Dev 25:1680-5. 2011..Our findings reveal that Pdx1 can work single-handedly as a potent context-dependent autonomous reprogramming agent, and suggest a postnatal differentiation evaluation stage involved in normal endocrine maturation...
- Spatial and temporal expression of the Cre gene under the control of the MMTV-LTR in different lines of transgenic miceK U Wagner
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha 68198 6805, USA
Transgenic Res 10:545-53. 2001..We have now characterized in depth the expression of the MMTV-Cre transgene using the ROSA26-lox-Stop-lox-LacZ reporter strain to determine the temporal and spatial activation of Cre on the level of single ..
- Neurogenin 3-expressing progenitor cells in the gastrointestinal tract differentiate into both endocrine and non-endocrine cell typesSusan E Schonhoff
Division of Gastroenterology, GRASP Digestive Disease Center, Tufts New England Medical Center, Boston, MA 02111, USA
Dev Biol 270:443-54. 2004..Thus, ngn3 expression occurs in mixed populations of immature cells that are not irreversibly committed to endocrine differentiation...
- Dynamic contribution of nestin-expressing stem cells to adult neurogenesisDiane C Lagace
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
J Neurosci 27:12623-9. 2007....
- A myocardial lineage derives from Tbx18 epicardial cellsChen Leng Cai
Skaggs School of Pharmacy, University of California, San Diego, La Jolla, California 92093, USA
Nature 454:104-8. 2008..The pluripotency of Tbx18 proepicardial cells provides a theoretical framework for applying these progenitors to effect cardiac repair and regeneration...
- Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cellsYunfu Sun
Skaggs School of Pharmacy, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Dev Biol 304:286-96. 2007..Our studies suggest a role for Isl1 in these distinct domains of expression within the heart...
- Intestine-specific ablation of mouse atonal homolog 1 (Math1) reveals a role in cellular homeostasisNoah F Shroyer
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Gastroenterology 132:2478-88. 2007..We hypothesized that Math1 is important in cell fate commitment, and therefore mediates proliferative homeostasis and the adaptive response following intestinal resection in the adult intestine...
- Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline inductionGusztav Belteki
Samuel Lunenfeld Research Institute, Mount Sinai Hospital 600 University Avenue, Toronto, Ontario, Canada M5G 1X5
Nucleic Acids Res 33:e51. 2005..To ensure reliable rtTA expression in a broad range of cell types, we have targeted the rtTA transgene into the ROSA26 locus...
- Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skinHugo J Snippert
Hubrecht Institute KNAW Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, Netherlands
Science 327:1385-9. 2010..Adult Lgr6+ cells executed long-term wound repair, including the formation of new hair follicles. We conclude that Lgr6 marks the most primitive epidermal stem cell...
- Distinct roles of transcription factors brn3a and brn3b in controlling the development, morphology, and function of retinal ganglion cellsTudor C Badea
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuron 61:852-64. 2009..These findings reveal distinct roles for Brn3a and Brn3b in programming RGC diversity, and they illustrate the broad utility of germline methods for genetically manipulating and visualizing individual identified mammalian neurons...
- Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liverChristoph H Osterreicher
Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 108:308-13. 2011..These findings suggest that FSP1 is a marker of a specific subset of inflammatory macrophages in liver injury, fibrosis, and cancer...
- A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathwayDónal O'Carroll
The Laboratory for Lymphocyte Signaling, The Rockefeller University, New York, New York 10021, USA
Genes Dev 21:1999-2004. 2007..Collectively, our data identify Ago2 as a highly specialized member of the Argonaute family with an essential nonredundant Slicer-independent function within the mammalian miRNA pathway...
- Beta1 integrin expression on endothelial cells is required for angiogenesis but not for vasculogenesisHarikrishna Tanjore
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Dev Dyn 237:75-82. 2008..These results indicate that beta1 integrin expression on vascular endothelial cells is crucial for embryonic angiogenesis but dispensable for vasculogenesis...
- TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat functionLiang Zhou
The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
Nature 453:236-40. 2008..Therefore, the decision of antigen-stimulated cells to differentiate into either T(H)17 or T(reg) cells depends on the cytokine-regulated balance of RORgammat and Foxp3...
- Combinations of genetic mutations in the adult neural stem cell compartment determine brain tumour phenotypesThomas S Jacques
Neural Development Unit, UCL Institute of Child Health and Department of Histopathology, Great Ormond Street Hospital, London, UK
EMBO J 29:222-35. 2010..Our study underlines an important role of stem cells and the relevance of initial genetic mutations in the pathogenesis and phenotype of brain tumours...
- Transgenic expression of haem oxygenase-1 in pancreatic beta cells protects non-obese mice used as a model of diabetes from autoimmune destruction and prolongs graft survival following islet transplantationS H Huang
Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China
Diabetologia 53:2389-400. 2010..We investigated whether transgenic expression of Ho-1 (also known as Hmox1) in pancreatic beta cells would protect NOD mice from autoimmune damage and prolong graft survival following islet transplantation...
- Pet-1 is required across different stages of life to regulate serotonergic functionChen Liu
Case Western Reserve University, School of Medicine, Department of Neurosciences, Cleveland, Ohio, USA
Nat Neurosci 13:1190-8. 2010..These findings indicate that Pet-1 is required across the lifespan of the mouse and that behavioral pathogenesis can result from both developmental and adult-onset alterations in serotonergic transcription...
- NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegenerationShin H Kang
The Solomon H Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21205, USA
Neuron 68:668-81. 2010..These results indicate that NG2+ cells in the normal CNS are oligodendrocyte precursors with restricted lineage potential and that cell loss and gliosis are not sufficient to alter the lineage potential of these progenitors...
- Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin productionMichal Safran
Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 103:105-10. 2006....
- Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transitionDebra F Higgins
Department of Medicine, Renal Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Clin Invest 117:3810-20. 2007....
- NG2 cells generate both oligodendrocytes and gray matter astrocytesXiaoqin Zhu
Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269 3156, USA
Development 135:145-57. 2008..These observations suggest that NG2+ cells are precursors of oligodendrocytes and some protoplasmic astrocytes in gray matter...
- Lhx2 selector activity specifies cortical identity and suppresses hippocampal organizer fateVishakha S Mangale
Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India
Science 319:304-9. 2008..In addition to providing functional evidence for Lhx2 selector activity, these findings show that the cortical hem is a hippocampal organizer...
- Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytesChangchun Xiao
Immune Disease Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Immunol 9:405-14. 2008..This mechanism probably contributed to the lymphoproliferative disease and autoimmunity of miR-17-92-transgenic mice and contributes to lymphoma development in patients with amplifications of the miR-17-92 coding region...
- Early forebrain wiring: genetic dissection using conditional Celsr3 mutant miceLibing Zhou
Developmental Neurobiology, Universite Catholique de Louvain, 1200 Bruxelles, Belgique
Science 320:946-9. 2008..These observations provide in vivo evidence that Celsr3-mediated interactions between axons and guidepost cells govern axonal tract formation in mammals...
- Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birthAkari Inada
Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 105:19915-9. 2008..expressing human carbonic anhydrase II (CAII) promoter: Cre recombinase (Cre) or inducible CreER(TM) to cross with ROSA26 loxP-Stop-loxP LacZ reporter mice...
- Inactivation of p53 and Pten promotes invasive bladder cancerAnna M Puzio-Kuter
Department of Urology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Genes Dev 23:675-80. 2009..Our integrated analyses of mouse and human bladder cancer provide a rationale for investigating mTOR inhibition for treatment of patients with invasive disease...
- Characterization of Nkx6-2-derived neocortical interneuron lineagesVitor H Sousa
Neuroscience Program, Smilow Research Center, New York University, New York, NY 10016, USA
Cereb Cortex 19:i1-10. 2009....
- Distinct self-renewal and differentiation phases in the niche of infrequently dividing hair follicle stem cellsYing V Zhang
Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
Cell Stem Cell 5:267-78. 2009..We propose that large clusters of tissue stem cells behave as populations whose maintenance involves unidirectional daughter-cell-fate decisions...
- The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemiaUlf Klein
Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA
Cancer Cell 17:28-40. 2010..miR-15a/16-1-deletion accelerates the proliferation of both human and mouse B cells by modulating the expression of genes controlling cell-cycle progression. These results define the role of 13q14 deletions in the pathogenesis of CLL...
- Beta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanismAnn C Zovein
Department of Molecular, Cellular, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA
Dev Cell 18:39-51. 2010..Combined, our findings demonstrate that beta1 integrin functions upstream of Par3 as part of a molecular cascade required for endothelial cell polarity and lumen formation...
- The antiapoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophagesIvan Dzhagalov
Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
Blood 109:1620-6. 2007..These data suggest that Mcl-1 plays a nonredundant role in promoting the survival of neutrophils but not macrophages...
- Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasiaJean Paul De La O
Department of Human Genetics, University of Utah, 15 North 2030 East, Room 2100, Salt Lake City, UT 84112, USA
Proc Natl Acad Sci U S A 105:18907-12. 2008..At the cellular level, Notch/Kras coactivation promotes rapid reprogramming of acinar cells to a duct-like phenotype, providing an explanation for how a characteristically ductal tumor can arise from nonductal acinar cells...
- A highly efficient Escherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNAE C Lee
Mouse Cancer Genetics Program, National Cancer Institute Frederick, Frederick, Maryland 21702, USA
Genomics 73:56-65. 2001....
- Beta1-class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortexD Graus-Porta
Friedrich Miescher Institute, Maulbeerstr 66, 4058, Basel, Switzerland
Neuron 31:367-79. 2001..The phenotype of the beta1-deficient mice resembles pathological changes observed in human cortical dysplasias, suggesting that defective integrin-mediated signal transduction contributes to the development of some of these diseases...
- A transgenic mouse model of metastatic carcinoma involving transdifferentiation of a gastric epithelial lineage progenitor to a neuroendocrine phenotypeAndrew J Syder
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 101:4471-6. 2004....
- Targeted insertion of the Cre-recombinase gene at the phenylethanolamine n-methyltransferase locus: a new model for studying the developmental distribution of adrenergic cellsSteven N Ebert
Department of Pharmacology, Georgetown University Medical Center, Washington, DC 20057, USA
Dev Dyn 231:849-58. 2004..epinephrine biosynthetic enzyme phenylethanolamine n-methyltransferase (Pnmt) and crossed these Pnmt-Cre mice with ROSA26 reporter (R26R) mice to activate LacZ (encoding beta-galactosidase) expression in cells that were selectively ..
- An ES cell system for rapid, spatial and temporal analysis of gene function in vitro and in vivoJunhao Mao
Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
Nucleic Acids Res 33:e155. 2005..in a novel embryonic stem (ES) cell line enables rapid identification of targeting to the ubiquitously expressed Rosa26 locus...
- SOX9 is required for maintenance of the pancreatic progenitor cell poolPhilip A Seymour
Department of Developmental and Cell Biology, University of California, Irvine, CA 92697 2300, USA
Proc Natl Acad Sci U S A 104:1865-70. 2007..These findings will be of major significance for the development of in vitro protocols for cell replacement therapies...
- Mosaic removal of hedgehog signaling in the adult SVZ reveals that the residual wild-type stem cells have a limited capacity for self-renewalFrancesca Balordi
Smilow Neuroscience Program and the Department of Cell Biology, Smilow Research Center, New York University School of Medicine, New York, New York 10016, USA
J Neurosci 27:14248-59. 2007..These results demonstrate that ongoing hedgehog signaling is required to maintain adult neural stem cells and that their ability to self-renew is limited...
- Cutaneous cancer stem cell maintenance is dependent on beta-catenin signallingIlaria Malanchi
Ecole Polytechnique Fédérale de Lausanne ISREC Swiss Institute for Experimental Cancer Research and National Center of Competence in Research Molecular Oncology, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
Nature 452:650-3. 2008..Because Wnt/beta-catenin signalling is not essential for normal epidermal homeostasis, such a mechanistic difference may thus be targeted to eliminate CSCs and consequently eradicate squamous cell carcinomas...
- The anti-apoptotic Bcl-2 family member Mcl-1 promotes T lymphocyte survival at multiple stagesIvan Dzhagalov
Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
J Immunol 181:521-8. 2008..Furthermore, we demonstrate that Mcl-1 functions together with Bcl-xL to promote double-positive thymocyte survival. Thus, Mcl-1 is a critical anti-apoptotic factor for the survival of T cells at multiple stages in vivo...
- An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic miceMilena Traykova-Brauch
Department of Cellular and Molecular Pathology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Nat Med 14:979-84. 2008..These experiments establish Pax8-rtTA mice as a powerful tool for modeling renal diseases in transgenic mice...
- Genetic mapping of Foxb1-cell lineage shows migration from caudal diencephalon to telencephalon and lateral hypothalamusTianyu Zhao
Department of Genes and Behavior, Brain Development Group, Max Planck Institute of Biophysical Chemistry, Gottingen, Germany
Eur J Neurosci 28:1941-55. 2008..The expanded neuroepithelium generates abundant neurons for the medial hypothalamus at the tuberal level. Finally, we have uncovered novel diencephalon-to-telencephalon migrations into septum, piriform cortex and amygdala...
- Response of small intestinal epithelial cells to acute disruption of cell division through CDC25 deletionGwanghee Lee
Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 106:4701-6. 2009..These findings have implications for the development of novel, less cytotoxic cancer chemotherapeutic drugs that specifically target the cell cycle...
- Transcription factor Gbx2 acts cell-nonautonomously to regulate the formation of lineage-restriction boundaries of the thalamusLi Chen
Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
Development 136:1317-26. 2009..We propose that, within the developing thalamus, the dynamic and differential expression of Gbx2 may be involved in the specific segregation of thalamic neurons, leading to partition of the thalamus into different nuclei...
- Lineage analysis of quiescent regenerative stem cells in the adult brain by genetic labelling reveals spatially restricted neurogenic niches in the olfactory bulbClaudio Giachino
Department of Molecular Embryology, Max Planck Institute of Immunobiology, Stubeweg 51, D 79108 Freiburg, Germany
Eur J Neurosci 30:9-24. 2009..In summary, using conditional lineage tracing we have identified neonatal cells that are the source of neurogenic and regenerative neural stem cells in the adult SVZ and occupy a novel neurogenic niche in the OB...
- Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in miceEric Camerer
Cardiovascular Research Institute, UCSF, San Francisco, California 94158 2517, USA
J Clin Invest 119:1871-9. 2009..Our results suggest that the blood communicates with blood vessels via plasma S1P to maintain vascular integrity and regulate vascular leak. This pathway prevents lethal responses to leak-inducing mediators in mouse models...
- Arcuate nucleus expression of NKX2.1 and DLX and lineages expressing these transcription factors in neuropeptide Y(+), proopiomelanocortin(+), and tyrosine hydroxylase(+) neurons in neonatal and adult miceCindy L Yee
Nina Ireland Laboratory of Developmental Neurobiology, University of California San Francisco, Genetics and Development, San Francisco, California 94158 2611, USA
J Comp Neurol 517:37-50. 2009..These results have implications for the genetic control of arcuate development and function and for the utility of the Nkx2.1-Cre and Dlx5/6i-Cre mouse lines to alter gene expression in the developing arcuate...
- Lin-Sca-1+CD49fhigh stem/progenitors are tumor-initiating cells in the Pten-null prostate cancer modelDavid J Mulholland
Departments of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, California 90095 1735, USA
Cancer Res 69:8555-62. 2009..Therefore, the LSC subpopulation is capable of initiating a cancerous phenotype that recapitulates the pathology seen in the primary lesions of the Pten mutant prostate model...
- Inhibitory role of sphingosine 1-phosphate receptor 2 in macrophage recruitment during inflammationJason Michaud
Department of Cell Biology, Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
J Immunol 184:1475-83. 2010..Our results suggest that S1P serves as a negative regulator of macrophage recruitment by inhibiting migration in these cells and identify an additional facet to the regulation of leukocyte trafficking by S1P...
- A primary cilia-dependent etiology for midline facial disordersSamantha A Brugmann
Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University, Stanford, CA 94305, USA
Hum Mol Genet 19:1577-92. 2010..These data also raise the possibility that genes encoding ciliary proteins are candidates for human conditions of hypertelorism and FNDs...
- Endothelial alpha5 and alphav integrins cooperate in remodeling of the vasculature during developmentArjan van der Flier
Howard Hughes Medical Institute, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Development 137:2439-49. 2010..These integrins on other cells, and/or other integrins on endothelial cells, might contribute to fibronectin assembly and vascular development...
- Somatomedin: Autologous Regulator of Bone FormationErnesto Canalis; Fiscal Year: 2008..These investigations should clarify the role of CHOP in bone cell differentiation and function. [unreadable] [unreadable]..
- Muscle protein synthesis and gene expression in myostatin-deficient miceStephen L Welle; Fiscal Year: 2010..Knowledge of the physiological and molecular effects of reducing myostatin activity in mature muscle will reveal potential benefits and limitations of anti-myostatin therapy. ..
- CHANGES IN GENE EXPRESSION IN SENESCENT MUSCLEStephen Welle; Fiscal Year: 2003..abstract_text> ..
- Conditional Deletion of Dnaic1 as a Model of Primary Ciliary DyskinesiaLAWRENCE OSTROWSKI; Fiscal Year: 2007..If successful, this model will also provide a novel system to investigate other questions concerning pulmonary health and disease. [unreadable] [unreadable] [unreadable]..
- Calcium channels at ribbon synapses in the retinaCATHERINE MORGANS; Fiscal Year: 2008..The results of these experiments will provide insight into the composition and functional organization of retinal ribbon synapses and into the perturbation of retinal function associated with CSNB2. ..
- GENETIC AND BEHAVIORAL DISSECTION OF INHIBITORY CONTROLXiaoxi Zhuang; Fiscal Year: 2008..Aim 3 is to test directly the hypothesis that impaired D2 receptor function underlies impaired inhibitory control using mice that lack or have reduced postsynaptic D2 receptors. ..
- Epigenetic Mechanisms in Motor Habits StabilityXiaoxi Zhuang; Fiscal Year: 2007..These studies will point to potential epigenetic interventions in the future that may be able to treat drug addition by reversing motor habits. [unreadable] [unreadable] [unreadable]..
- Skeletal Biology and Medicine ConferenceMone Zaidi; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable]..
- Phenotypic screen in mouse embryonic for TGF-beta signaling mutationsJAY VIVIAN; Fiscal Year: 2007..Cell-based mutation screening strategies as developed in this proposal can be applied to any active biochemical pathway in mouse ES cells, to generate mouse lines for analysis in vivo. [unreadable] [unreadable] [unreadable]..
- The Role of NFATc1 and Calcineurin in Bone RemodelingMone Zaidi; Fiscal Year: 2007..unreadable] [unreadable]..
- Redox-mediated NF-kappaB activation by LPS and IL-1JOHN ENGELHARDT; Fiscal Year: 2008..Findings from these studies may lead to alternative therapeutic approaches targeting the liver by which to abrogate the detrimental effects of systemic cytokine production during sepsis. ..
- Central Serotonergic Pathways Regulating Energy BalanceLORA HEISLER; Fiscal Year: 2007....
- CYSTEINE PROTEASES IN MHC CLASS II ANTIGEN PRESENTATIONHarold Chapman; Fiscal Year: 2007..abstract_text> ..
- 2006 Cancer Model MechanismsWilliam Kaelin; Fiscal Year: 2006..unreadable] [unreadable] [unreadable] [unreadable]..
- ROLE OF THE LCR IN HUMAN BETA-GLOBIN GENE REGULATIONKENNETH PETERSON; Fiscal Year: 2001..Specific Aim 3 will test the role of the LCR sequences in LCR complex formation and globin gene regulation using transgenic mice containing mutant beta-globin loci by applying FRET. ..
- Lung epithelial and vascular morphogenesisDavid Warburton; Fiscal Year: 2006..abstract_text> ..
- MECHANISMS OF RAAV TRANSDUCTION IN THE AIRWAYJOHN ENGELHARDT; Fiscal Year: 2008..Further elucidation of rAAV transduction biology in the airway will aid in the development of clinically applicable methods for increasing the efficacy of rAAV gene transfer in vivo. ..
- Molecular Studies of Brain MalformationsHuaiyu Hu; Fiscal Year: 2007....
- TGF-beta Signaling in Chondrocyte DifferentiationRosa Serra; Fiscal Year: 2008..The results of these studies will enhance our understanding of molecular events involved in development and maintenance of the skeletal system. [unreadable] [unreadable]..
- Mechanisms of In Vivo Cell FusionAndrew Duncan; Fiscal Year: 2008..Aim 2: To determine relevant properties of fusion-derived hepatocytes. Aim 3: To enhance in vivo cell fusion by expression of fusogenic viral envelope proteins. [unreadable] [unreadable] [unreadable]..
- Excitatory Activity Control of Adult NeurogenesisKarl Deisseroth; Fiscal Year: 2008..program that can be transitioned to a tenure-track position in a psychiatry department, where I look forward to continuing with 75-80% research and 20-25% patient care, and opportunities to teach and mentor others ..
- Role of ALK3 in atrioventricular valve developmentVinciane Gaussin; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- Transactivation of Fetal HemoglobinKENNETH PETERSON; Fiscal Year: 2007..This proposal will generate unique tools and new strategies to understand mechanisms of ?-globin gene regulation for treatment of SCD. ..
- AUTOCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESISDavid Warburton; Fiscal Year: 2009..Aim 4: To determine the role of tyrosine phosphorylation in protein-protein interaction and supra-molecular assembly of mSPRY2 with SHP2 and FRS2. Aim 5: To determine the functional importance of Shp2 in lung morphogenesis in vivo. ..
- Transcriptional Control of Early Coronary Vascular DevelopmentRAVINDRA P MISRA; Fiscal Year: 2010....
- Molecular Imaging of Novel Cardiomyocyte Stem CellsSTEVEN EBERT; Fiscal Year: 2009..Aim 2: In vivo magnetic resonance imaging (MRI) of transplanted cardiomyocyte stem (Pnmt+) cells. Aim 3: In vivo bioluminescence imaging (BLI) of transplanted cardiomyocyte stem (Pnmt+) cells. (End of Abstract) ..
- Chromatin-based cellular memory in neural stem cellsDaniel Lim; Fiscal Year: 2009..Furthermore, our studies may lead to discoveries of how derangements in chromatin remodeling can lead to the development of brain tumors. ..
- DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATIONDavid Warburton; Fiscal Year: 2010..Inosine may function as a low molecular weight therapeutic to ameliorate lung injury, protect lung progenitor cells and hence to promote recovery of the alveolar epithelium from acute injury in both adult and neonate. ..
- HNF6 Function in the Pancreatic Endocrine LineageMaureen A Gannon; Fiscal Year: 2010..e. is HNF6 needed only at early stages of endocrine specification, or is it required continuously during embryogenesis for terminal differentiation and acquisition of mature function. ..
- ROLE OF MYOSTATIN IN CACHEXIASe Jin Lee; Fiscal Year: 2005..abstract_text> ..
- DAB2 AND RAS REGULATIONXiangxi Xu; Fiscal Year: 2001..These mechanistic studies of Dab2 will enhance our understanding of its role in cell growth regulation and the possible involvement in breast and ovary tumorigenicity. ..
- GENDER AND RISK OF DRUG INDUCED CARDIAC ARRHYTHMIASSTEVEN EBERT; Fiscal Year: 2001....
- TGF BETA EXPRESSION FOLLOWING ISCHEMIC ACUTE RENAL FAILDAVID BASILE; Fiscal Year: 2002..abstract_text> ..
- SMAD MEDIATED SIGNALING DURING LUNG MORPHOGENESISWei Shi; Fiscal Year: 2002..The results of this project will provide new rationales for novel therapeutic strategies to modulate TGF-beta signaling during lung development, injury, repair, and disease. ..
- IDENTIFICATION OF BIOCHEMICAL ABNORMALITIES IN PCD CILIALAWRENCE OSTROWSKI; Fiscal Year: 2002..Further studies of the role of these proteins in the assembly and function of cilia may also result in improved treatment for other air way diseases. ..
- TG737 SIGNALING PATHWAY AND POLYCYSTIC KIDNEYBradley Yoder; Fiscal Year: 2003..Overall, results generated from this proposal will give important insight into the biological function of Tg737 and how disruption of the Tg737/polycystin-1 signaling pathway results in the formation of renal cyst. ..
- DEVELOPMENTAL MECHANISMS OF HOXA5 SPATIAL REGULATIONLucie Jeannotte; Fiscal Year: 2003..Completion of these aims will provide critical information required for elucidating the pathway controlling Hoxa5 expression, information useful to develop a detailed understanding of regional patterning during development. ..
- NEURONAL MIGRATION IN THE DEVELOPING BRAINHuaiyu Hu; Fiscal Year: 2003....
- CD38/ADP RIBOSYL CYCLASE R0LE IN OSTEOCLAST REGULATIONMone Zaidi; Fiscal Year: 2003..Taken together, the studies should provide mechanistic insights into the role of the NAD+/CD38/cADPr/Ca2+ system in osteoclast control. ..
- The Role of Sonic Hedgehog in telencephalic patterningRobert Machold; Fiscal Year: 2004..This work will hopefully lead to a deeper understanding of regional specification in the developing forebrain. ..
- Locus-linked Regulatory Motifs of Globin Gene SwitchingKENNETH PETERSON; Fiscal Year: 2004....
- Excess TGF beta in neonatal lung injury and repairDavid Warburton; Fiscal Year: 2004..abstract_text> ..
- CNS Disease and Autoimmunity of Glutamate ReceptorsScott Rogers; Fiscal Year: 2005..abstract_text> ..
- SRF/MYOCD: new targets in Alzheimer's neurovasculatureJOSEPH MIANO; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- A Ciliated Cell-Specific Promoter for Gene Therapy of CFLAWRENCE OSTROWSKI; Fiscal Year: 2005..Specific Aim 3: To demonstrate correction of the CF phenotype in both in vitro and in vivo models by targeted expression of the normal CFTR gene in ciliated cells. ..
- SACRAL CREST CELLS AND ENTERIC NEURODEVELOPMENTRaj Kapur; Fiscal Year: 2005..The results of this study will further our understanding of normal enteric neurodevelopment and congenital disorders of intestinal motility. ..
- THE ROLE OF SRF IN CARDIAC FUNCTION AND DEVELOPMENTRAVINDRA MISRA; Fiscal Year: 2005..These studies will both elucidate the mechanisms by which SRF functions in heart and will establish powerful new methodologies for studying heart formation and function. ..
- The role of HNF4 in gastrointestinal developmentMichele Battle; Fiscal Year: 2006..By understanding how this transcription factor functions in the gut, greater insight into the fundamental molecular processes underlying gut development wilt be gained. ..
- TGFb in stromal epithelial interactions in mammary glandRosa Serra; Fiscal Year: 2005..The proposed experiments will improve our understanding of stromal-epithelial interactions in the mammary gland. ..
- Kim-1 in Renal Epithelial Cell Motility and AdhesionBENJAMIN HUMPHREYS; Fiscal Year: 2005..The proposed studies will have great relevance in understanding the molecular mechanisms of renal regeneration and renal cell cancer invasion and metastasis. ..
- Analysis of a Retinoid-Induced Tumor Suppressor in SMCJOSEPH MIANO; Fiscal Year: 2006..Such information has enormous potential for understanding and treating human vascular Idisease and other pathological disorders, including cancer where retinoids have been in clinical use for years. ..
- ROLE OF THE PTEN PATHWAY IN MELANOMAMarcus Bosenberg; Fiscal Year: 2005..He has also completed Ph.D. training in cell biology. The proposed research will be carried out in the laboratory of Dr. Ronald DePinho at the Dana-Farber Cancer Institute, an affiliate of the Harvard Medical School. ..
- NEURAL AND MECHANICAL REGULATION OF SLOW MYOSINKaryn Esser; Fiscal Year: 2004....
- Skeletal Development and Remodeling in Health, Disease and AgingMone Zaidi; Fiscal Year: 2005..A local forum, which will provide the non-scientific public an informal opportunity to learn about the latest research and therapies emerging in the field, is also planned. ..
- The Role of Cartilage Link Protein 1 (Crtl1) in Heart DevelopmentARNO WESSELS; Fiscal Year: 2010..Understanding the role of Crtl1, and Crtl1-associated mechanisms, in heart development may further our knowledge of the etiology of a variety of these malformations including the mechanisms that lead to muscular septal defects. ..
- The role of nyctalopin in the mammalian retinaCATHERINE MORGANS; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Adipogenesis, Obesity and InflammationPhilipp Scherer; Fiscal Year: 2005..Some sessions will be held jointly with the "Diabetes Mellitus and the control of Cellular Energy Metabolism" meeting that will effectively complement the obesity meeting. ..
- Locus-linked Regulatory Motifs of Globin Gene SwitchingKENNETH PETERSON; Fiscal Year: 2008..abstract_text> ..
- Foxm 1b endocrine pancreas growth and regenerationMaureen Gannon; Fiscal Year: 2009..A thorough understanding of Foxml regulation of 3 cell mass may lead to strategies for maintaining 3 cell mass and enhancing 3 cell proliferation in diabetics. ..
- TGF-beta Signaling in Mesenchymal ChondroprogenitorsAnna Spagnoli; Fiscal Year: 2007..Understanding the role of TGF-beta in MCC biology will provide a framework for therapeutic manipulations to optimize the use of MCC in cartilage diseases. ..
- New Insights into Animals Models of DiabetesEdward Leiter; Fiscal Year: 2003..The meeting is planned for 200 participants. Because of limited seating capacity in The Jackson Laboratory's auditorium, the meeting venue will be the Bar Harbor Regency Hotel, where participants will be housed and fed. ..
- The role of EGFR signaling in progression of Kras-induced pacreatic tumorsAnna Means; Fiscal Year: 2007..The studies proposed here investigate EGFR signaling as a potential biomarker and/or therapeutic target, by studying its effects on tumorigenesis in a mouse model of pancreatic cancer. [unreadable] [unreadable] [unreadable]..
- TGFbeta/Bmp Signaling during Mammalian Lens DevelopmentYasuhide Furuta; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- Function of GATA-6 in Vascular Smooth MuscleJohn Lepore; Fiscal Year: 2005..End of Abstract) ..