Ifnar1

Summary

Gene Symbol: Ifnar1
Description: interferon (alpha and beta) receptor 1
Alias: CD118, Ifar, Ifnar, Ifrc, Infar, interferon alpha/beta receptor 1, IFN-R-1, IFN-alpha/beta receptor 1, IFN-alpha/betaR, INF-a receptor, type I interferon receptor 1
Species: mouse

Top Publications

  1. ncbi Type I IFN signaling is crucial for host resistance against different species of pathogenic bacteria
    Giuseppe Mancuso
    Dipartimento di Patologia e Microbiologia Sperimentale, Universita degli Studi di Messina, Via Consolare Valeria 1, 98125 Messina, Italy
    J Immunol 178:3126-33. 2007
  2. pmc Multiple host barriers restrict poliovirus trafficking in mice
    Sharon K Kuss
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS Pathog 4:e1000082. 2008
  3. ncbi Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
    Hiroki Kato
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    Nature 441:101-5. 2006
  4. ncbi IRF-7 is the master regulator of type-I interferon-dependent immune responses
    Kenya Honda
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 434:772-7. 2005
  5. doi Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions
    Ahmed N Hegazy
    Experimental Immunology, Department of Rheumatology and Clinical Immunology, Charite University Medicine Berlin, 10117 Berlin, Germany
    Immunity 32:116-28. 2010
  6. doi Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells
    Maria T Pallotta
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Nat Immunol 12:870-8. 2011
  7. pmc Corneal avascularity is due to soluble VEGF receptor-1
    Balamurali K Ambati
    Department of Ophthalmology, Medical College of Georgia and Augusta Veterans Affairs Medical Center, Augusta, Georgia 30907, USA
    Nature 443:993-7. 2006
  8. pmc Interferon-dependent immunity is essential for resistance to primary dengue virus infection in mice, whereas T- and B-cell-dependent immunity are less critical
    Sujan Shresta
    Division of Infectious Diseases, School of Public Health, University of California at Berkeley, Berkeley, California 94720, USA
    J Virol 78:2701-10. 2004
  9. pmc Type I interferon production enhances susceptibility to Listeria monocytogenes infection
    Ryan M O'Connell
    Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, 8 240 Factor Bldg, 10833 Le Conte Ave, 90095, USA
    J Exp Med 200:437-45. 2004
  10. pmc A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons alpha and beta and alters macrophage responses
    S Y Hwang
    Institute of Reproduction and Development, Monash Medical Centre, Monash University, Clayton, Victoria, Australia
    Proc Natl Acad Sci U S A 92:11284-8. 1995

Research Grants

  1. VIRUSES AND AUTOIMMUNE DISEASE
    Michael Oldstone; Fiscal Year: 2001
  2. STUDIES OF A NEW MYELIN GENE THAT CAUSES CNS DISEASE
    Michael Oldstone; Fiscal Year: 2001
  3. Pathogenesis Studies in Scrapie (TSE Diseases)
    Michael Oldstone; Fiscal Year: 2003
  4. Viruses and Diabetes
    Michael Oldstone; Fiscal Year: 2005
  5. MEASLES VIRUS STUDIES IN A TRANSGENIC MODEL
    Michael Oldstone; Fiscal Year: 2007
  6. Aging Disease--Prion/Transgenic/Immunologic Studies
    Michael Oldstone; Fiscal Year: 2008
  7. Arenavirus Receptor-Structure/Function Studies
    Michael B Oldstone; Fiscal Year: 2010
  8. Therapeutics to Prevent/Treat Lassa Fever Virus
    Michael B Oldstone; Fiscal Year: 2010
  9. Anti-Tumor Autoimmunity by lymphopenia T cell Expansion
    Roberto Baccala; Fiscal Year: 2008
  10. Bacterial artificial chromosomes for HSV genomics
    David Leib; Fiscal Year: 2004

Scientific Experts

Detail Information

Publications175 found, 100 shown here

  1. ncbi Type I IFN signaling is crucial for host resistance against different species of pathogenic bacteria
    Giuseppe Mancuso
    Dipartimento di Patologia e Microbiologia Sperimentale, Universita degli Studi di Messina, Via Consolare Valeria 1, 98125 Messina, Italy
    J Immunol 178:3126-33. 2007
    ..These data may be useful to devise alternative strategies to treat bacterial infections...
  2. pmc Multiple host barriers restrict poliovirus trafficking in mice
    Sharon K Kuss
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS Pathog 4:e1000082. 2008
    ..poliovirus population bottlenecks in PVR mice and in PVR mice that lack the interferon alpha/beta receptor (PVR-IFNAR-/-), an important component of innate immunity...
  3. ncbi Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
    Hiroki Kato
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    Nature 441:101-5. 2006
    ..Together, our data show that RIG-I and MDA5 distinguish different RNA viruses and are critical for host antiviral responses...
  4. ncbi IRF-7 is the master regulator of type-I interferon-dependent immune responses
    Kenya Honda
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 434:772-7. 2005
    ..Thus, all elements of IFN responses, whether the systemic production of IFN in innate immunity or the local action of IFN from plasmacytoid dendritic cells in adaptive immunity, are under the control of IRF-7...
  5. doi Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions
    Ahmed N Hegazy
    Experimental Immunology, Department of Rheumatology and Clinical Immunology, Charite University Medicine Berlin, 10117 Berlin, Germany
    Immunity 32:116-28. 2010
    ..Stable coexpression of GATA-3 and T-bet provides a molecular concept for the long-term coexistence of Th2 and Th1 cell lineage characteristics in single memory T cells...
  6. doi Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells
    Maria T Pallotta
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Nat Immunol 12:870-8. 2011
    ..Thus, IDO has a tonic, nonenzymic function that contributes to TGF-β-driven tolerance in noninflammatory contexts...
  7. pmc Corneal avascularity is due to soluble VEGF receptor-1
    Balamurali K Ambati
    Department of Ophthalmology, Medical College of Georgia and Augusta Veterans Affairs Medical Center, Augusta, Georgia 30907, USA
    Nature 443:993-7. 2006
    ....
  8. pmc Interferon-dependent immunity is essential for resistance to primary dengue virus infection in mice, whereas T- and B-cell-dependent immunity are less critical
    Sujan Shresta
    Division of Infectious Diseases, School of Public Health, University of California at Berkeley, Berkeley, California 94720, USA
    J Virol 78:2701-10. 2004
    ....
  9. pmc Type I interferon production enhances susceptibility to Listeria monocytogenes infection
    Ryan M O'Connell
    Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, 8 240 Factor Bldg, 10833 Le Conte Ave, 90095, USA
    J Exp Med 200:437-45. 2004
    ..monocytogenes-induced splenic apoptosis in IRF3- and IFNAR1-deficient mice...
  10. pmc A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons alpha and beta and alters macrophage responses
    S Y Hwang
    Institute of Reproduction and Development, Monash Medical Centre, Monash University, Clayton, Victoria, Australia
    Proc Natl Acad Sci U S A 92:11284-8. 1995
    ..in vivo role(s) of type I interferons (IFNs) and to determine the role of a component of the type I IFN receptor (IFNAR1) in mediating responses to these IFNs, we generated mice with a null mutation (-/-) in the IFNAR1 gene...
  11. pmc Type I interferon modulates monocyte recruitment and maturation in chronic inflammation
    Pui Y Lee
    Center for Autoimmune Disease, University of Florida, Gainesville, 32610 0221, USA
    Am J Pathol 175:2023-33. 2009
    ..Continuous monocyte recruitment and the lack of terminal differentiation induced by IFN-I may help sustain the chronic inflammatory response...
  12. pmc Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10
    Kindra M Kelly-Scumpia
    Department Surgery, University of Florida College of Medicine, Gainesville, FL 32610, USA
    J Exp Med 207:319-26. 2010
    ..lethal bacterial infections where systemic inflammation predominates, mice deficient in IFN-alpha/beta receptor (IFNAR) display decreased systemic inflammation and improved outcome...
  13. ncbi Recognition of cytosolic DNA activates an IRF3-dependent innate immune response
    Daniel B Stetson
    Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 24:93-103. 2006
    ..These findings define an innate immune response to DNA linked to type I interferon production...
  14. pmc Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells
    Suk Jo Kang
    Howard Hughes Medical Institute, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0795, USA
    Immunity 29:819-33. 2008
    ..Thus, spatial organization of the immune response by DCs between 6 and 24 hr ensures functional activation of innate cells, which restricts pathogens before adaptive immunity is fully activated...
  15. pmc MyD88 and Type I interferon receptor-mediated chemokine induction and monocyte recruitment during Listeria monocytogenes infection
    Ting Jia
    Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 183:1271-8. 2009
    ..phase promotes prolonged, higher level MCP-1 secretion and is dependent on signaling via the type I IFN receptor (IFNAR). Although attenuated L...
  16. doi Prominent role for plasmacytoid dendritic cells in mucosal T cell-independent IgA induction
    Hiroyuki Tezuka
    Department of Biodefense Research, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Immunity 34:247-57. 2011
    ..Our findings provide insight into the molecular basis of pDC conditioning to induce mucosal TI IgA production, which may lead to improvements in vaccination strategies and treatment for mucosal-related disorders...
  17. doi Streptococcus pneumoniae stimulates a STING- and IFN regulatory factor 3-dependent type I IFN production in macrophages, which regulates RANTES production in macrophages, cocultured alveolar epithelial cells, and mouse lungs
    Uwe Koppe
    Department of Internal Medicine Infectious Diseases and Pulmonary Medicine, Charite University Medicine Berlin, 13353 Berlin, Germany
    J Immunol 188:811-7. 2012
    ..In conclusion, we identified an immune sensing pathway detecting S. pneumoniae that triggers a type I IFN response and positively regulates RANTES production...
  18. doi Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon-dependent exhaustion
    Taku Sato
    Department of Immunology, Akita University Graduate School of Medicine, Akita, Japan
    Nat Med 15:696-700. 2009
    ..Our findings provide insight into the molecular basis for the maintenance of HSC quiescence and may lead to improvements in bone marrow transplantation and type I IFN-based therapies for viral infection and cancer...
  19. pmc Type I interferons produced by resident renal cells may promote end-organ disease in autoantibody-mediated glomerulonephritis
    Anna Marie Fairhurst
    Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8884, USA
    J Immunol 183:6831-8. 2009
    ..Collectively, these studies indicate that an important contribution of IFN-I toward the disease pathology seen in systemic autoimmunity may be exercised at the level of the end-organ...
  20. pmc Measles virus spread and pathogenesis in genetically modified mice
    B Mrkic
    Institut für Molekularbiologie Abt I, Universitat Zurich, Zurich, Switzerland
    J Virol 72:7420-7. 1998
    ..We conclude that in mice alpha/beta interferon controls MV infection and that a high-affinity receptor facilitates, but is not strictly required for, MV spread and pathogenesis...
  21. pmc Type I interferon signaling regulates Ly6C(hi) monocytes and neutrophils during acute viral pneumonia in mice
    Sang Uk Seo
    Mucosal Immunology Section, International Vaccine Institute, Seoul, South Korea
    PLoS Pathog 7:e1001304. 2011
    ..IFN-I receptor knockout (Ifnar1⁻/⁻) mice develop significant defects in the infiltration of Ly6C(hi) monocytes in the lung after influenza ..
  22. pmc Two roads diverged: interferon alpha/beta- and interleukin 12-mediated pathways in promoting T cell interferon gamma responses during viral infection
    L P Cousens
    Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
    J Exp Med 189:1315-28. 1999
    ....
  23. pmc Type I interferon sensitizes lymphocytes to apoptosis and reduces resistance to Listeria infection
    Javier A Carrero
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    J Exp Med 200:535-40. 2004
    ..Together, these data suggest that type I IFN signaling is detrimental to handling of a bacterial pathogen and may enhance the susceptibility of lymphocytes undergoing apoptosis in response to bacterial pore-forming toxins...
  24. pmc The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-beta production
    Tina Mahieu
    Department for Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology and Ghent University, Technologiepark 927, B 9052 Ghent, Belgium
    Proc Natl Acad Sci U S A 103:2292-7. 2006
    ..In contrast to TLR4-deficient mice, SPRET/Ei mice resist both LPS and sepsis induced with Klebsiella pneumoniae...
  25. ncbi CD8 T cells specific for lymphocytic choriomeningitis virus require type I IFN receptor for clonal expansion
    Peter Aichele
    Institute for Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg, Freiburg, Germany
    J Immunol 176:4525-9. 2006
    ..Lack of type I IFNR expression by P14 T cells did not affect cell division after LCMV infection but interfered with clonal expansion. Thus, direct type I IFN signaling is essential for CD8 T cell survival in certain viral infections...
  26. pmc Virus-induced unfolded protein response attenuates antiviral defenses via phosphorylation-dependent degradation of the type I interferon receptor
    Jianghuai Liu
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell Host Microbe 5:72-83. 2009
    Phosphorylation-dependent ubiquitination and degradation of the IFNAR1 chain of the type I interferon (IFN) receptor is regulated by two different pathways, one of which is ligand independent...
  27. doi Double-stranded RNA induces pancreatic beta-cell apoptosis by activation of the toll-like receptor 3 and interferon regulatory factor 3 pathways
    Zeynep Dogusan
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Route de Lennik, 808, CP 618, B 1070 Brussels, Belgium
    Diabetes 57:1236-45. 2008
    ..We presently investigated the mediators and downstream effectors of dsRNA-induced beta-cell death...
  28. pmc SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor
    K G Suresh Kumar
    Department of Animal Biology, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104 6046, USA
    EMBO J 22:5480-90. 2003
    ..Mechanisms underlying down-regulation of the type I interferon receptor consisting of IFNAR1 and IFNAR2 subunits remain largely unknown...
  29. pmc Biologic consequences of Stat1-independent IFN signaling
    M P Gil
    Department of Pathology and Immunology, Center for Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 98:6680-5. 2001
    ..Thus, the IFN receptors engage alternative Stat1-independent signaling pathways that have important physiological consequences...
  30. pmc The role of alpha/beta and gamma interferons in development of immunity to influenza A virus in mice
    G E Price
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912 3175, USA
    J Virol 74:3996-4003. 2000
    ..However, IFN-alpha/beta seems to be a valid factor in determining tissue tropism and replicative rates of highly virulent influenza virus strains as reported previously by others, and this aspect is discussed here...
  31. pmc Mice lacking the type I interferon receptor are resistant to Listeria monocytogenes
    Victoria Auerbuch
    Department of Molecular and Cell Biology, 508 Barker Hall, University of California, Berkeley, 94720, USA
    J Exp Med 200:527-33. 2004
    ..The results of this study suggest that L. monocytogenes might be exploiting an innate antiviral response to promote its pathogenesis...
  32. pmc Increased susceptibility to bacterial superinfection as a consequence of innate antiviral responses
    Alexander A Navarini
    Institute for Experimental Immunology, University Hospital Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 103:15535-9. 2006
    ..The finding that the innate antiviral immune response reduces the antibacterial granulocyte defense offers an explanation for enhanced susceptibility to bacterial superinfection during viral disease...
  33. pmc Establishment of a bluetongue virus infection model in mice that are deficient in the alpha/beta interferon receptor
    Eva Calvo-Pinilla
    Centro de Investigacion en Sanidad Animal, CISA INIA, Madrid, Spain
    PLoS ONE 4:e5171. 2009
    ..Herein, we show that adult mice deficient in type I IFN receptor (IFNAR((-/-))) are highly susceptible to BTV-4 and BTV-8 infection when the virus is administered intravenously...
  34. pmc Regulation of inflammatory monocyte/macrophage recruitment from the bone marrow during murine cytomegalovirus infection: role for type I interferons in localized induction of CCR2 ligands
    Meredith J Crane
    Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    J Immunol 183:2810-7. 2009
    ....
  35. pmc Role of the individual interferon systems and specific immunity in mice in controlling systemic dissemination of attenuated pseudorabies virus infection
    P Grob
    Institute of Virology, University of Zurich, CH 8057 Zurich, Switzerland
    J Virol 73:4748-54. 1999
    ..We present evidence that mice with an intact gamma IFN system but without mature B and T cells were able to prevent systemic dissemination of gE-TK-PRV...
  36. pmc Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection
    Ganesh A Kolumam
    Department of Immunology, University of Washington, Seattle, 98195, USA
    J Exp Med 202:637-50. 2005
    ..Thus, IFN-IR signaling in CD8 T cells is critical for the generation of effector and memory cells in response to viral infection...
  37. ncbi Bone marrow stromal cell antigen 2 is a specific marker of type I IFN-producing cells in the naive mouse, but a promiscuous cell surface antigen following IFN stimulation
    Amanda L Blasius
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 177:3260-5. 2006
    ..Finally, we show that BST2 resides within an intracellular compartment corresponding to the Golgi apparatus, and may be involved in trafficking secreted cytokines in IPC...
  38. pmc B7-1/2 (CD80/CD86) direct signaling to B cells enhances IgG secretion
    Friederike C Rau
    Center for Comparative Medicine, University of California, Davis, Davis, CA 95616, USA
    J Immunol 183:7661-71. 2009
    ..Taken together, these results identify direct signaling through B7-1/2 as a potent regulator of IgG secretion by previously activated B cells...
  39. pmc Alpha/beta interferon protects against lethal West Nile virus infection by restricting cellular tropism and enhancing neuronal survival
    Melanie A Samuel
    Department of Molecular Microbiology, Washington University School of Medicine, Campus Box 8051, 660 S Euclid Ave, St Louis, MO 63110, USA
    J Virol 79:13350-61. 2005
    ..Collectively, our data suggest that IFN-alpha/beta controls WNV infection by restricting tropism and viral burden and by preventing death of infected neurons...
  40. ncbi Influenza virus infection causes global respiratory tract B cell response modulation via innate immune signals
    W L William Chang
    Center for Comparative Medicine and
    J Immunol 178:1457-67. 2007
    ....
  41. ncbi An important role for type III interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity
    Nina Ank
    Institute of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark
    J Immunol 180:2474-85. 2008
    ..mice with respect to clearance of a panel of different viruses, whereas mice lacking the type I IFN receptor (IFNAR(-/-)) were significantly impaired...
  42. ncbi Type I interferons directly regulate lymphocyte recirculation and cause transient blood lymphopenia
    Elisabeth Kamphuis
    Division of Immunology, Paul Ehrlich Institut, Paul Ehrlich Str 51 59, D 63225 Langen, Germany
    Blood 108:3253-61. 2006
    ..In all cases analyzed, lymphopenia was critically dependent on type I interferon receptor (IFNAR) signaling...
  43. ncbi Cutting edge: enhancement of antibody responses through direct stimulation of B and T cells by type I IFN
    Agnes Le Bon
    The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, UK
    J Immunol 176:2074-8. 2006
    ..These results indicate that IFN-alphabetaR signaling in both B and T cells plays an important role in the stimulation of Ab responses by IFN-alphabeta...
  44. ncbi Coordinated and distinct roles for IFN-alpha beta, IL-12, and IL-15 regulation of NK cell responses to viral infection
    Khuong B Nguyen
    Deparment of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA
    J Immunol 169:4279-87. 2002
    ....
  45. pmc Toll-like receptor 9-induced type I IFN protects mice from experimental colitis
    Kyoko Katakura
    Department of Medicine, UCSD, La Jolla, California 92093 0663, USA
    J Clin Invest 115:695-702. 2005
    ..They also underscore the important protective role of type I IFN in intestinal homeostasis and suggest that strategies to modulate innate immunity may be of therapeutic value for the treatment of intestinal inflammatory conditions...
  46. ncbi Expression of the p60 autolysin enhances NK cell activation and is required for listeria monocytogenes expansion in IFN-gamma-responsive mice
    Jessica Humann
    Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 178:2407-14. 2007
    ..L. monocytogenes deficient for p60 (Deltap60) competed well for expansion in mice doubly deficient for IFNAR1 and IFN-gammaR1 or singly deficient for IFN-gammaR1, but not in wild-type, IFNAR1(-/-), or TLR2(-/-) mice...
  47. ncbi IFN-alpha/beta signaling is required for polarization of cytokine responses toward a protective type 1 pattern during experimental cryptococcosis
    Carmelo Biondo
    Dipartimento di Patologia e Microbiologia Sperimentale, Universita degli Studi di Messina, Messina, Italy
    J Immunol 181:566-73. 2008
    ..neoformans. Our data demonstrate that type I IFN signaling is required for polarization of cytokine responses toward a protective type I pattern during cryptococcal infection...
  48. pmc Plasmacytoid dendritic cell-derived type I interferon is crucial for the adjuvant activity of Toll-like receptor 7 agonists
    Deepa Rajagopal
    King s College London, Peter Gorer Department of Immunobiology, Guy s Hospital, London, United Kingdom
    Blood 115:1949-57. 2010
    ..This study, therefore, identifies sufficient IFN-alpha production by PDC as an important determinant of vaccine efficacy...
  49. pmc Induction of IFN-alphabeta enables Listeria monocytogenes to suppress macrophage activation by IFN-gamma
    Manira Rayamajhi
    National Jewish Health, Denver, CO 80206, USA
    J Exp Med 207:327-37. 2010
    ..Furthermore, the increased resistance of mice lacking the IFN-alphabeta receptor (IFNAR(-/-)) to L...
  50. pmc Conidia but not yeast cells of the fungal pathogen Histoplasma capsulatum trigger a type I interferon innate immune response in murine macrophages
    Diane O Inglis
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143 0414, USA
    Infect Immun 78:3871-82. 2010
    ..Interestingly, H. capsulatum growth was restricted in mice lacking the type I IFN receptor, indicating that an intact host type I IFN response is required for full virulence of H. capsulatum in mice...
  51. doi Signal 3 requirement for memory CD8+ T-cell activation is determined by the infectious pathogen
    Selina J Keppler
    Institute for Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg, Freiburg, Germany
    Eur J Immunol 41:3176-86. 2011
    ..In summary, our results reveal an essential role for direct inflammatory cytokine signaling in secondary T-cell responses...
  52. pmc The toll-like receptor 3-mediated antiviral response is important for protection against poliovirus infection in poliovirus receptor transgenic mice
    Yuko Abe
    Neurovirology Project, Tokyo Metropolitan Institute of Medical Science, 2 1 6 Kamikitazawa, Setagaya Ku, Tokyo 156 8506, Japan
    J Virol 86:185-94. 2012
    ..These results suggest that multiple pathways are involved in the antiviral response in mice and that the TLR3-TRIF-mediated signaling pathway plays an essential role in the antiviral response against PV infection...
  53. doi The negative costimulatory molecule PD-1 modulates the balance between immunity and tolerance via miR-21
    Dimitrios Iliopoulos
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Eur J Immunol 41:1754-63. 2011
    ....
  54. ncbi Type I IFN receptor signals directly stimulate local B cells early following influenza virus infection
    Elizabeth S Coro
    Center for Comparative Medicine, University of California, Davis, 95616, USA
    J Immunol 176:4343-51. 2006
    ..Thus, ligand(s) of the type I IFNR are direct nonredundant early innate signals that regulate local antiviral B cell responses...
  55. doi Type I IFN regulate DC turnover in vivo
    Fabrizio Mattei
    Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    Eur J Immunol 39:1807-18. 2009
    ..We found that DC, especially the CD8alpha(+) subset, from type I IFN receptor knock out (IFNAR KO) mice, display a reduced turnover rate when compared with DC from WT mice, as revealed by BrdU labelling ..
  56. ncbi Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA
    G Uze
    Laboratoire d Oncologie virale, CNRS UPR 274, Villejuif, France
    Cell 60:225-34. 1990
    ..Mouse cells expressing the cDNA become sensitive to the antiviral activity of and express binding sites for human interferon alpha, demonstrating that the cloned cDNA encodes a functional human interferon alpha receptor...
  57. ncbi Endogenous IFN-alpha beta suppresses colony-stimulating factor (CSF)-1-stimulated macrophage DNA synthesis and mediates inhibitory effects of lipopolysaccharide and TNF-alpha
    J A Hamilton
    Department of Medicine, University of Melbourne, The Royal Melbourne Hospital, Victoria, Australia
    J Immunol 156:2553-7. 1996
    ..it is proposed that the type I IFN receptor (IFNAR 1) "knockout" mice may be useful in delineating some of the in vivo actions of CSF-1, LPS, TNF-alpha, and possibly ..
  58. ncbi CD8(+) T cell-mediated skin disease in mice lacking IRF-2, the transcriptional attenuator of interferon-alpha/beta signaling
    S Hida
    Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Immunity 13:643-55. 2000
    ..IRF-2 may represent a unique negative regulator, attenuating IFN-alpha/beta-induced gene transcription, which is necessary for balancing the beneficial and harmful effects of IFN-alpha/beta signaling in the immune system...
  59. ncbi A unique mechanism for innate cytokine promotion of T cell responses to viral infections
    Gary C Pien
    Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    J Immunol 169:5827-37. 2002
    ..Because stimulation by microbial products is linked to innate cytokine expression, the studies also suggest a pathway for precisely limiting T cell functions to times of need...
  60. ncbi Identification of a TLR4- and TRIF-dependent activation program of dendritic cells
    Heike Weighardt
    Department of Surgery, Technical University Munich, Munich, Germany
    Eur J Immunol 34:558-64. 2004
    ..Together, these data therefore identify TRIF as a crucial regulator of TLR4-dependent dendritic cell responses...
  61. pmc Both viral and host factors contribute to neurovirulence of bovine herpesviruses 1 and 5 in interferon receptor-deficient mice
    Carlos Abril
    Institute of Virology Institute of Veterinary Pathology, University of Zurich, Zurich, Switzerland
    J Virol 78:3644-53. 2004
    ..We conclude that the alpha/beta interferon system had a protective effect, while an intact gamma interferon system was required for efficient replication of BHV-5 in mouse neurons and for the development of neurological disease...
  62. ncbi Monocyte chemoattractant protein-1 and CCR2 interactions are required for IFN-alpha/beta-induced inflammatory responses and antiviral defense in liver
    Kirsten L Hokeness
    Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    J Immunol 174:1549-56. 2005
    ....
  63. ncbi TLR-dependent induction of IFN-beta mediates host defense against Trypanosoma cruzi
    Ritsuko Koga
    Department of Molecular Genetics, Medical Institute of Bioregulation, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Immunol 177:7059-66. 2006
    ..Neutralization of IFN-beta in MyD88(-/-) macrophages led to enhanced T. cruzi growth. Cells from MyD88(-/-)IFNAR1(-/-) mice also showed impaired T. cruzi clearance...
  64. pmc Antitumor NK activation induced by the Toll-like receptor 3-TICAM-1 (TRIF) pathway in myeloid dendritic cells
    Takashi Akazawa
    Department of Immunology, Osaka Medical Center for Cancer, Nakamichi 1 3 2, Higashinari ku, Osaka 537 8511, Japan
    Proc Natl Acad Sci U S A 104:252-7. 2007
    ..This NK-dependent tumor regression did not occur in TICAM-1(-/-) or IFNAR(-/-) mice, whereas a normal NK antitumor response was induced in PKR(-/-), MyD88(-/-), IFN-beta(-/-), and wild-..
  65. pmc The feedback phase of type I interferon induction in dendritic cells requires interferon regulatory factor 8
    Prafullakumar Tailor
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 27:228-39. 2007
    ..Together, these data indicate that IRF8 magnifies the second phase of IFN transcription in DCs by prolonging binding of basic transcription machinery to the IFN promoters, thereby playing a role in innate immunity...
  66. ncbi TLR agonists promote marginal zone B cell activation and facilitate T-dependent IgM responses
    Anatoly V Rubtsov
    Integrated Department of Immunology, University of Colorado Denver and National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 180:3882-8. 2008
    ..Together, these data demonstrate that in vivo TLR agonist treatment enhances the early production of Ag-specific IgM and activates MZ B cells to promote their relocation...
  67. pmc Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN-beta induction via X-box binding protein 1
    Judith A Smith
    William S Rowe Division of Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Eur J Immunol 38:1194-203. 2008
    ....
  68. doi Bacterial endotoxin induces the release of high mobility group box 1 via the IFN-beta signaling pathway
    Ju Hyun Kim
    Department of Pathology, Hallym University College of Medicine, Chuncheon, Korea
    J Immunol 182:2458-66. 2009
    ..Our results suggest that HMGB1 release in sepsis is dependent on the IFN-beta signaling axis; thus, therapeutic agents that selectively inhibit IFN-beta signaling could be beneficial in the treatment of sepsis...
  69. pmc Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo
    Nelson C Di Paolo
    Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Immunity 31:110-21. 2009
    ..Thus, these data identify IL-1 alpha-IL-1RI as a key pathway allowing for the activation of proinflammatory responses to the virus, independently of its genomic nucleic acid recognition...
  70. ncbi Functional role of type I and type II interferons in antiviral defense
    U Muller
    Institute of Molecular Biology I, University of Zurich, Switzerland
    Science 264:1918-21. 1994
    ..Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant...
  71. pmc Differential regulation of constitutive major histocompatibility complex class I expression in T and B lymphocytes
    C K Lee
    Department of Pathology and Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, New York 10016, USA
    J Exp Med 190:1451-64. 1999
    ....
  72. ncbi Distinct requirements for IFNs and STAT1 in NK cell function
    C K Lee
    Department of Pathology, Kaplan Comprehensive Cancer Center, New York University School of Medicine, NY 10016, USA
    J Immunol 165:3571-7. 2000
    ..These results demonstrate that both IFN-alpha and IFN-gamma are required to maintain NK cell function and define a STAT1-dependent but partially IFN-independent pathway required for NK-mediated antitumor activity...
  73. ncbi Requirement for STAT1 in LPS-induced gene expression in macrophages
    Y Ohmori
    Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Ohio 44195, USA
    J Leukoc Biol 69:598-604. 2001
    ....
  74. ncbi The role of the Type I interferon response in the resistance of mice to filovirus infection
    M Bray
    Department of Viral Therapeutics, Virology Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD 21702 5011, USA
    J Gen Virol 82:1365-73. 2001
    ..The outcome of filovirus transfer between animal species appears to be determined by interactions between the virus and the innate immune response...
  75. pmc Critical role for alpha/beta and gamma interferons in persistence of lymphocytic choriomeningitis virus by clonal exhaustion of cytotoxic T cells
    R Ou
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Virol 75:8407-23. 2001
    ..We discuss the role of IFNs in influencing virus-specific T cells that determine the outcome of persistent infections...
  76. ncbi IFN-alpha/beta enhances BCR-dependent B cell responses
    Deborah Braun
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, 2781 Oeiras, Portugal
    Int Immunol 14:411-9. 2002
    ....
  77. ncbi Production of type I IFN sensitizes macrophages to cell death induced by Listeria monocytogenes
    Silvia Stockinger
    Vienna Biocenter and University of Vienna, Institute of Microbiology and Genetics, Austria
    J Immunol 169:6522-9. 2002
    ..The data stress the importance of type I IFN for the course of infections with intracellular bacteria and suggest that factors other than listeriolysin O contribute to macrophage death during Listeria infection...
  78. pmc The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression
    Josiane Ragimbeau
    Unité de Signalisation des Cytokines, CNRS URA 1961, Unite de Biologie des Interactions Cellulaires, CNRS URA 1960, Institut Pasteur, Paris 75724 Cedex 15, France
    EMBO J 22:537-47. 2003
    ..In the type I interferon receptor, Tyk2 associates with the IFNAR1 receptor subunit and positively influences ligand binding to the receptor complex...
  79. ncbi Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon
    Agnes Le Bon
    The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire RG20 7NN, England
    Nat Immunol 4:1009-15. 2003
    ..These data identify expression of IFN-alpha/beta as a mechanism for the induction of cross-priming during virus infections...
  80. pmc The alpha/beta interferon response controls tissue tropism and pathogenicity of poliovirus
    Miki Ida-Hosonuma
    Department of Microbiology and Immunology, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Tokyo 183 8526, Japan
    J Virol 79:4460-9. 2005
    ..in PVR-transgenic mice and PVR-transgenic mice deficient in the alpha/beta IFN receptor gene (PVR-transgenic/Ifnar knockout mice). PVR-transgenic/Ifnar knockout mice showed increased susceptibility to poliovirus...
  81. ncbi Type I IFNs provide a third signal to CD8 T cells to stimulate clonal expansion and differentiation
    Julie M Curtsinger
    Department of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 174:4465-9. 2005
    ..Provision of the third signal by either IFN-alpha beta or IL-12 results in regulation of the expression of a number of genes, including several that encode proteins critical for effector function...
  82. pmc A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells
    Gregory Gautier
    Laboratory for Immunological Research, Schering Plough, 69571 Dardilly, France
    J Exp Med 201:1435-46. 2005
    ..Strikingly, IL-12p70 but not IL-12p40 secretion was strongly reduced in BM-DC from STAT1(-/-) and IFNAR(-/-) mice...
  83. ncbi Critical roles for both STAT1-dependent and STAT1-independent pathways in the control of primary dengue virus infection in mice
    Sujan Shresta
    Division of Infectious Diseases, School of Public Health, University of California, Berkeley, CA 94720, USA
    J Immunol 175:3946-54. 2005
    ..Collectively, these data begin to define the nature of the STAT1-dependent vs the STAT1-independent pathway in vivo...
  84. ncbi Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity
    Jennifer E Fenner
    Centre for Functional Genomics and Human Disease, Monash Institute of Medical Research, Monash University, Clayton 3168, Australia
    Nat Immunol 7:33-9. 2006
    ..IFN-alpha and IFN-beta) and mice deficient in interferon-gamma or type I interferon receptor components (IFNAR1 or IFNAR2), we demonstrate here that SOCS1 deficiency amplified type I interferon antiviral and proinflammatory ..
  85. ncbi Cutting Edge: The direct action of type I IFN on CD4 T cells is critical for sustaining clonal expansion in response to a viral but not a bacterial infection
    Colin Havenar-Daughton
    Department of Immunology and Washington National Primate Center, University of Washington, 1959 Northeast Pacific Street, Seattle, WA 98195, USA
    J Immunol 176:3315-9. 2006
    ..Thus, direct IFN-I signals can play either a critical or minimal role in CD4 T cell clonal expansion depending on the specific pathogen...
  86. ncbi Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation
    Seiichi Kuwajima
    Department of Immunology, Akita University School of Medicine, Akita 010 8543, Japan
    Nat Immunol 7:740-6. 2006
    ..Interaction between CD40 on cDCs and CD40 ligand on pDCs led to IL-12 production by cDCs. Thus, IL-15-dependent crosstalk between cDCs and pDCs is essential for CpG-induced immune activation...
  87. ncbi Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon
    Luisa Cervantes-Barragan
    Research Department, Kantonal Hospital St Gallen, Switzerland, and Abeteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, Germany
    Blood 109:1131-7. 2007
    ..Taken together, our results suggest that rapid production of type I IFNs by pDCs is essential for the control of potentially lethal coronavirus infections...
  88. ncbi Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages
    Kohki Kawane
    Department of Genetics, Osaka University, Osaka 565 0871, Japan
    Nature 443:998-1002. 2006
    ....
  89. pmc Protective role of beta interferon in host defense against influenza A virus
    Iris Koerner
    Department of Virology, University of Freiburg, Hermann Herder Strasse 11, D 79104 Freiburg, Germany
    J Virol 81:2025-30. 2007
    ..Mx-wt) or mice carrying functional Mx1 alleles but lacking functional type I IFN receptors (designated Mx-IFNAR)...
  90. pmc Innate immune response to adenoviral vectors is mediated by both Toll-like receptor-dependent and -independent pathways
    Jiangao Zhu
    Department of Medicine, Duke University Medical Center, Box 3502, Durham, NC 27710, USA
    J Virol 81:3170-80. 2007
    ..Our results that suggest strategies to interfere with type I IFN pathway may improve the outcome of adenovirus-mediated gene therapy, whereas approaches to activate the type I IFN pathway may enhance vaccine potency...
  91. ncbi TLR signaling fine-tunes anti-influenza B cell responses without regulating effector T cell responses
    Alex K Heer
    Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology, Zurich Schlieren, Switzerland
    J Immunol 178:2182-91. 2007
    ..Taken together, these data reveal that TLR signaling is not required for anti-influenza T cell responses, but through both direct and indirect means orchestrates appropriate anti-influenza B cell responses...
  92. pmc Type I interferon signaling is required for activation of the inflammasome during Francisella infection
    Thomas Henry
    Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
    J Exp Med 204:987-94. 2007
    ..This connection underscores the importance of the cytosolic recognition of pathogens and highlights how multiple innate immunity pathways interact before commitment to critical host responses...
  93. pmc Establishment of a poliovirus oral infection system in human poliovirus receptor-expressing transgenic mice that are deficient in alpha/beta interferon receptor
    Seii Ohka
    Department of Microbiology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Virol 81:7902-12. 2007
    ..mice (Tg) carrying the human PV receptor (hPVR/CD155) gene and lacking the alpha/beta interferon receptor (IFNAR) gene (hPVR-Tg/IfnarKO) were sensitive to the oral administration of PV with 3% NaHCO3, whereas hPVR-Tg expressing ..
  94. ncbi Cutting edge: involvement of the type I IFN production and signaling pathway in lipopolysaccharide-induced IL-10 production
    Elmer Y Chang
    Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095, USA
    J Immunol 178:6705-9. 2007
    ..Our findings suggest a novel anti-inflammatory role for the type I IFN production and signaling pathway in regulating LPS response in bone marrow-derived macrophages...
  95. pmc MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis
    Matthew J Delano
    Department of Surgery, University of Florida College of Medicine, Gainesville, FL 32610, USA
    J Exp Med 204:1463-74. 2007
    ..GR-1(+)CD11b(+) cells contribute to sepsis-induced T cell suppression and preferential Th2 polarization...
  96. pmc High basal STAT4 balanced by STAT1 induction to control type 1 interferon effects in natural killer cells
    Takuya Miyagi
    Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA
    J Exp Med 204:2383-96. 2007
    ....
  97. ncbi A conserved IFN-alpha receptor tyrosine motif directs the biological response to type I IFNs
    Wenli Zhao
    Department of Microbiology, Columbia University, New York, NY 10032, USA
    J Immunol 180:5483-9. 2008
    ..their potent biological activities through an evolutionarily conserved IFN-alpha receptor (IFNAR), consisting of IFNAR1 and IFNAR2...
  98. ncbi Type I IFNs enhance susceptibility to Chlamydia muridarum lung infection by enhancing apoptosis of local macrophages
    Hongyu Qiu
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
    J Immunol 181:2092-102. 2008
    ..role of IFNIs in host resistance to chlamydial infection in vivo, we compared IFN-alpha/beta receptor knockout (IFNAR(-/-)) and wild-type control mice in susceptibility to Chlamydia trachomatis mouse pneumonitis (Chlamydia muridarum)..
  99. pmc Murine coronavirus mouse hepatitis virus is recognized by MDA5 and induces type I interferon in brain macrophages/microglia
    Jessica K Roth-Cross
    Department of Microbiology, University of Pennsylvania, School of Medicine, 36th Street and Hamilton Walk, Philadelphia, PA 19104 6076, USA
    J Virol 82:9829-38. 2008
    ..When infected with MHV, mice deficient in IFN-associated receptor expression (IFNAR(-/-)) became moribund by 48 h postinfection...
  100. ncbi Type I IFN-mediated protection of macrophages and dendritic cells secures control of murine coronavirus infection
    Luisa Cervantes-Barragan
    Research Department, Kantonal Hospital St Gallen, St Gallen, Switzerland
    J Immunol 182:1099-106. 2009
    ..Generation of bone marrow-chimeric mice expressing the type I IFN receptor (IFNAR) on either hemopoietic or non-bone marrow-derived cells revealed that the early control of MHV depended mainly on ..
  101. pmc Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop
    Nathaniel M Green
    Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 183:1569-76. 2009
    ..By contrast, IFNAR1(-/-) B cells did not produce cytokines, but did proliferate and up-regulate activation markers in response to ..

Research Grants13

  1. VIRUSES AND AUTOIMMUNE DISEASE
    Michael Oldstone; Fiscal Year: 2001
    ..The second order of business is to determine the role of "self" (islet-cell) antigens other than the initial triggering viral antigen in the pathogenetic process leading to and determine their role in IDDM. ..
  2. STUDIES OF A NEW MYELIN GENE THAT CAUSES CNS DISEASE
    Michael Oldstone; Fiscal Year: 2001
    ..Their studies in rodents combined with those of their collaborator, Dr. Martin, should begin to characterize the role played by MONP in neurologic disease. ..
  3. Pathogenesis Studies in Scrapie (TSE Diseases)
    Michael Oldstone; Fiscal Year: 2003
    ..This model should be useful to study pathophysiology of CWD as well as probing CWD strain differences. ..
  4. Viruses and Diabetes
    Michael Oldstone; Fiscal Year: 2005
    ....
  5. MEASLES VIRUS STUDIES IN A TRANSGENIC MODEL
    Michael Oldstone; Fiscal Year: 2007
    ..abstract_text> ..
  6. Aging Disease--Prion/Transgenic/Immunologic Studies
    Michael Oldstone; Fiscal Year: 2008
    ..Lastly, Jose Criado will continue his electrophysiology and behavioral studies on the normal function of PrP and on its aberrations during TSE disease. ..
  7. Arenavirus Receptor-Structure/Function Studies
    Michael B Oldstone; Fiscal Year: 2010
    ..These findings have relevance for biodefense of several viruses including LFV. ..
  8. Therapeutics to Prevent/Treat Lassa Fever Virus
    Michael B Oldstone; Fiscal Year: 2010
    ..We anticipate making a significant contribution to drug development to treat these BSL-4 agents. ..
  9. Anti-Tumor Autoimmunity by lymphopenia T cell Expansion
    Roberto Baccala; Fiscal Year: 2008
    ..The results will define the role of homeostatic T cell proliferation in tumor autoimmunity, and provide new approaches to the treatment of cancer. [unreadable] [unreadable]..
  10. Bacterial artificial chromosomes for HSV genomics
    David Leib; Fiscal Year: 2004
    ..abstract_text> ..
  11. A VEE Replicon-Based Vaccine for Dengue Virus
    Laura White; Fiscal Year: 2006
    ..abstract_text> ..
  12. Recruitment of memory CD8+ T cells to the lung airways
    JACOB KOHLMEIER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  13. Development of Cellular Assays of Dengue Virus Infection
    Priscilla Yang; Fiscal Year: 2008
    ..These inhibitors can be used to study how dengue virus interacts with its host, and they may also be useful in developing therapies for the treatment of dengue virus infections. [unreadable] [unreadable] [unreadable]..