Genomes and Genes
Gene Symbol: Ifnar1
Description: interferon (alpha and beta) receptor 1
Alias: CD118, Ifar, Ifnar, Ifrc, Infar, interferon alpha/beta receptor 1, IFN-R-1, IFN-alpha/beta receptor 1, IFN-alpha/betaR, INF-a receptor, type I interferon receptor 1
Publications175 found, 100 shown here
- Type I IFN signaling is crucial for host resistance against different species of pathogenic bacteriaGiuseppe Mancuso
Dipartimento di Patologia e Microbiologia Sperimentale, Universita degli Studi di Messina, Via Consolare Valeria 1, 98125 Messina, Italy
J Immunol 178:3126-33. 2007..These data may be useful to devise alternative strategies to treat bacterial infections...
- Multiple host barriers restrict poliovirus trafficking in miceSharon K Kuss
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
PLoS Pathog 4:e1000082. 2008..poliovirus population bottlenecks in PVR mice and in PVR mice that lack the interferon alpha/beta receptor (PVR-IFNAR-/-), an important component of innate immunity...
- Differential roles of MDA5 and RIG-I helicases in the recognition of RNA virusesHiroki Kato
Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
Nature 441:101-5. 2006..Together, our data show that RIG-I and MDA5 distinguish different RNA viruses and are critical for host antiviral responses...
- IRF-7 is the master regulator of type-I interferon-dependent immune responsesKenya Honda
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
Nature 434:772-7. 2005..Thus, all elements of IFN responses, whether the systemic production of IFN in innate immunity or the local action of IFN from plasmacytoid dendritic cells in adaptive immunity, are under the control of IRF-7...
- Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functionsAhmed N Hegazy
Experimental Immunology, Department of Rheumatology and Clinical Immunology, Charite University Medicine Berlin, 10117 Berlin, Germany
Immunity 32:116-28. 2010..Stable coexpression of GATA-3 and T-bet provides a molecular concept for the long-term coexistence of Th2 and Th1 cell lineage characteristics in single memory T cells...
- Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cellsMaria T Pallotta
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
Nat Immunol 12:870-8. 2011..Thus, IDO has a tonic, nonenzymic function that contributes to TGF-β-driven tolerance in noninflammatory contexts...
- Corneal avascularity is due to soluble VEGF receptor-1Balamurali K Ambati
Department of Ophthalmology, Medical College of Georgia and Augusta Veterans Affairs Medical Center, Augusta, Georgia 30907, USA
Nature 443:993-7. 2006....
- Interferon-dependent immunity is essential for resistance to primary dengue virus infection in mice, whereas T- and B-cell-dependent immunity are less criticalSujan Shresta
Division of Infectious Diseases, School of Public Health, University of California at Berkeley, Berkeley, California 94720, USA
J Virol 78:2701-10. 2004....
- Type I interferon production enhances susceptibility to Listeria monocytogenes infectionRyan M O'Connell
Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, 8 240 Factor Bldg, 10833 Le Conte Ave, 90095, USA
J Exp Med 200:437-45. 2004..monocytogenes-induced splenic apoptosis in IRF3- and IFNAR1-deficient mice...
- A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons alpha and beta and alters macrophage responsesS Y Hwang
Institute of Reproduction and Development, Monash Medical Centre, Monash University, Clayton, Victoria, Australia
Proc Natl Acad Sci U S A 92:11284-8. 1995..in vivo role(s) of type I interferons (IFNs) and to determine the role of a component of the type I IFN receptor (IFNAR1) in mediating responses to these IFNs, we generated mice with a null mutation (-/-) in the IFNAR1 gene...
- Type I interferon modulates monocyte recruitment and maturation in chronic inflammationPui Y Lee
Center for Autoimmune Disease, University of Florida, Gainesville, 32610 0221, USA
Am J Pathol 175:2023-33. 2009..Continuous monocyte recruitment and the lack of terminal differentiation induced by IFN-I may help sustain the chronic inflammatory response...
- Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10Kindra M Kelly-Scumpia
Department Surgery, University of Florida College of Medicine, Gainesville, FL 32610, USA
J Exp Med 207:319-26. 2010..lethal bacterial infections where systemic inflammation predominates, mice deficient in IFN-alpha/beta receptor (IFNAR) display decreased systemic inflammation and improved outcome...
- Recognition of cytosolic DNA activates an IRF3-dependent innate immune responseDaniel B Stetson
Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Immunity 24:93-103. 2006..These findings define an innate immune response to DNA linked to type I interferon production...
- Regulation of hierarchical clustering and activation of innate immune cells by dendritic cellsSuk Jo Kang
Howard Hughes Medical Institute, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0795, USA
Immunity 29:819-33. 2008..Thus, spatial organization of the immune response by DCs between 6 and 24 hr ensures functional activation of innate cells, which restricts pathogens before adaptive immunity is fully activated...
- MyD88 and Type I interferon receptor-mediated chemokine induction and monocyte recruitment during Listeria monocytogenes infectionTing Jia
Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
J Immunol 183:1271-8. 2009..phase promotes prolonged, higher level MCP-1 secretion and is dependent on signaling via the type I IFN receptor (IFNAR). Although attenuated L...
- Prominent role for plasmacytoid dendritic cells in mucosal T cell-independent IgA inductionHiroyuki Tezuka
Department of Biodefense Research, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
Immunity 34:247-57. 2011..Our findings provide insight into the molecular basis of pDC conditioning to induce mucosal TI IgA production, which may lead to improvements in vaccination strategies and treatment for mucosal-related disorders...
- Streptococcus pneumoniae stimulates a STING- and IFN regulatory factor 3-dependent type I IFN production in macrophages, which regulates RANTES production in macrophages, cocultured alveolar epithelial cells, and mouse lungsUwe Koppe
Department of Internal Medicine Infectious Diseases and Pulmonary Medicine, Charite University Medicine Berlin, 13353 Berlin, Germany
J Immunol 188:811-7. 2012..In conclusion, we identified an immune sensing pathway detecting S. pneumoniae that triggers a type I IFN response and positively regulates RANTES production...
- Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon-dependent exhaustionTaku Sato
Department of Immunology, Akita University Graduate School of Medicine, Akita, Japan
Nat Med 15:696-700. 2009..Our findings provide insight into the molecular basis for the maintenance of HSC quiescence and may lead to improvements in bone marrow transplantation and type I IFN-based therapies for viral infection and cancer...
- Type I interferons produced by resident renal cells may promote end-organ disease in autoantibody-mediated glomerulonephritisAnna Marie Fairhurst
Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8884, USA
J Immunol 183:6831-8. 2009..Collectively, these studies indicate that an important contribution of IFN-I toward the disease pathology seen in systemic autoimmunity may be exercised at the level of the end-organ...
- Measles virus spread and pathogenesis in genetically modified miceB Mrkic
Institut für Molekularbiologie Abt I, Universitat Zurich, Zurich, Switzerland
J Virol 72:7420-7. 1998..We conclude that in mice alpha/beta interferon controls MV infection and that a high-affinity receptor facilitates, but is not strictly required for, MV spread and pathogenesis...
- Type I interferon signaling regulates Ly6C(hi) monocytes and neutrophils during acute viral pneumonia in miceSang Uk Seo
Mucosal Immunology Section, International Vaccine Institute, Seoul, South Korea
PLoS Pathog 7:e1001304. 2011..IFN-I receptor knockout (Ifnar1⁻/⁻) mice develop significant defects in the infiltration of Ly6C(hi) monocytes in the lung after influenza ..
- Two roads diverged: interferon alpha/beta- and interleukin 12-mediated pathways in promoting T cell interferon gamma responses during viral infectionL P Cousens
Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
J Exp Med 189:1315-28. 1999....
- Type I interferon sensitizes lymphocytes to apoptosis and reduces resistance to Listeria infectionJavier A Carrero
Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
J Exp Med 200:535-40. 2004..Together, these data suggest that type I IFN signaling is detrimental to handling of a bacterial pathogen and may enhance the susceptibility of lymphocytes undergoing apoptosis in response to bacterial pore-forming toxins...
- The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-beta productionTina Mahieu
Department for Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology and Ghent University, Technologiepark 927, B 9052 Ghent, Belgium
Proc Natl Acad Sci U S A 103:2292-7. 2006..In contrast to TLR4-deficient mice, SPRET/Ei mice resist both LPS and sepsis induced with Klebsiella pneumoniae...
- CD8 T cells specific for lymphocytic choriomeningitis virus require type I IFN receptor for clonal expansionPeter Aichele
Institute for Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg, Freiburg, Germany
J Immunol 176:4525-9. 2006..Lack of type I IFNR expression by P14 T cells did not affect cell division after LCMV infection but interfered with clonal expansion. Thus, direct type I IFN signaling is essential for CD8 T cell survival in certain viral infections...
- Virus-induced unfolded protein response attenuates antiviral defenses via phosphorylation-dependent degradation of the type I interferon receptorJianghuai Liu
Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Cell Host Microbe 5:72-83. 2009Phosphorylation-dependent ubiquitination and degradation of the IFNAR1 chain of the type I interferon (IFN) receptor is regulated by two different pathways, one of which is ligand independent...
- Double-stranded RNA induces pancreatic beta-cell apoptosis by activation of the toll-like receptor 3 and interferon regulatory factor 3 pathwaysZeynep Dogusan
Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Route de Lennik, 808, CP 618, B 1070 Brussels, Belgium
Diabetes 57:1236-45. 2008..We presently investigated the mediators and downstream effectors of dsRNA-induced beta-cell death...
- SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptorK G Suresh Kumar
Department of Animal Biology, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104 6046, USA
EMBO J 22:5480-90. 2003..Mechanisms underlying down-regulation of the type I interferon receptor consisting of IFNAR1 and IFNAR2 subunits remain largely unknown...
- Biologic consequences of Stat1-independent IFN signalingM P Gil
Department of Pathology and Immunology, Center for Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 98:6680-5. 2001..Thus, the IFN receptors engage alternative Stat1-independent signaling pathways that have important physiological consequences...
- The role of alpha/beta and gamma interferons in development of immunity to influenza A virus in miceG E Price
Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912 3175, USA
J Virol 74:3996-4003. 2000..However, IFN-alpha/beta seems to be a valid factor in determining tissue tropism and replicative rates of highly virulent influenza virus strains as reported previously by others, and this aspect is discussed here...
- Mice lacking the type I interferon receptor are resistant to Listeria monocytogenesVictoria Auerbuch
Department of Molecular and Cell Biology, 508 Barker Hall, University of California, Berkeley, 94720, USA
J Exp Med 200:527-33. 2004..The results of this study suggest that L. monocytogenes might be exploiting an innate antiviral response to promote its pathogenesis...
- Increased susceptibility to bacterial superinfection as a consequence of innate antiviral responsesAlexander A Navarini
Institute for Experimental Immunology, University Hospital Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
Proc Natl Acad Sci U S A 103:15535-9. 2006..The finding that the innate antiviral immune response reduces the antibacterial granulocyte defense offers an explanation for enhanced susceptibility to bacterial superinfection during viral disease...
- Establishment of a bluetongue virus infection model in mice that are deficient in the alpha/beta interferon receptorEva Calvo-Pinilla
Centro de Investigacion en Sanidad Animal, CISA INIA, Madrid, Spain
PLoS ONE 4:e5171. 2009..Herein, we show that adult mice deficient in type I IFN receptor (IFNAR((-/-))) are highly susceptible to BTV-4 and BTV-8 infection when the virus is administered intravenously...
- Regulation of inflammatory monocyte/macrophage recruitment from the bone marrow during murine cytomegalovirus infection: role for type I interferons in localized induction of CCR2 ligandsMeredith J Crane
Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
J Immunol 183:2810-7. 2009....
- Role of the individual interferon systems and specific immunity in mice in controlling systemic dissemination of attenuated pseudorabies virus infectionP Grob
Institute of Virology, University of Zurich, CH 8057 Zurich, Switzerland
J Virol 73:4748-54. 1999..We present evidence that mice with an intact gamma IFN system but without mature B and T cells were able to prevent systemic dissemination of gE-TK-PRV...
- Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infectionGanesh A Kolumam
Department of Immunology, University of Washington, Seattle, 98195, USA
J Exp Med 202:637-50. 2005..Thus, IFN-IR signaling in CD8 T cells is critical for the generation of effector and memory cells in response to viral infection...
- Bone marrow stromal cell antigen 2 is a specific marker of type I IFN-producing cells in the naive mouse, but a promiscuous cell surface antigen following IFN stimulationAmanda L Blasius
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
J Immunol 177:3260-5. 2006..Finally, we show that BST2 resides within an intracellular compartment corresponding to the Golgi apparatus, and may be involved in trafficking secreted cytokines in IPC...
- B7-1/2 (CD80/CD86) direct signaling to B cells enhances IgG secretionFriederike C Rau
Center for Comparative Medicine, University of California, Davis, Davis, CA 95616, USA
J Immunol 183:7661-71. 2009..Taken together, these results identify direct signaling through B7-1/2 as a potent regulator of IgG secretion by previously activated B cells...
- Alpha/beta interferon protects against lethal West Nile virus infection by restricting cellular tropism and enhancing neuronal survivalMelanie A Samuel
Department of Molecular Microbiology, Washington University School of Medicine, Campus Box 8051, 660 S Euclid Ave, St Louis, MO 63110, USA
J Virol 79:13350-61. 2005..Collectively, our data suggest that IFN-alpha/beta controls WNV infection by restricting tropism and viral burden and by preventing death of infected neurons...
- Influenza virus infection causes global respiratory tract B cell response modulation via innate immune signalsW L William Chang
Center for Comparative Medicine and
J Immunol 178:1457-67. 2007....
- An important role for type III interferon (IFN-lambda/IL-28) in TLR-induced antiviral activityNina Ank
Institute of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark
J Immunol 180:2474-85. 2008..mice with respect to clearance of a panel of different viruses, whereas mice lacking the type I IFN receptor (IFNAR(-/-)) were significantly impaired...
- Type I interferons directly regulate lymphocyte recirculation and cause transient blood lymphopeniaElisabeth Kamphuis
Division of Immunology, Paul Ehrlich Institut, Paul Ehrlich Str 51 59, D 63225 Langen, Germany
Blood 108:3253-61. 2006..In all cases analyzed, lymphopenia was critically dependent on type I interferon receptor (IFNAR) signaling...
- Cutting edge: enhancement of antibody responses through direct stimulation of B and T cells by type I IFNAgnes Le Bon
The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, UK
J Immunol 176:2074-8. 2006..These results indicate that IFN-alphabetaR signaling in both B and T cells plays an important role in the stimulation of Ab responses by IFN-alphabeta...
- Coordinated and distinct roles for IFN-alpha beta, IL-12, and IL-15 regulation of NK cell responses to viral infectionKhuong B Nguyen
Deparment of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA
J Immunol 169:4279-87. 2002....
- Toll-like receptor 9-induced type I IFN protects mice from experimental colitisKyoko Katakura
Department of Medicine, UCSD, La Jolla, California 92093 0663, USA
J Clin Invest 115:695-702. 2005..They also underscore the important protective role of type I IFN in intestinal homeostasis and suggest that strategies to modulate innate immunity may be of therapeutic value for the treatment of intestinal inflammatory conditions...
- Expression of the p60 autolysin enhances NK cell activation and is required for listeria monocytogenes expansion in IFN-gamma-responsive miceJessica Humann
Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Immunol 178:2407-14. 2007..L. monocytogenes deficient for p60 (Deltap60) competed well for expansion in mice doubly deficient for IFNAR1 and IFN-gammaR1 or singly deficient for IFN-gammaR1, but not in wild-type, IFNAR1(-/-), or TLR2(-/-) mice...
- IFN-alpha/beta signaling is required for polarization of cytokine responses toward a protective type 1 pattern during experimental cryptococcosisCarmelo Biondo
Dipartimento di Patologia e Microbiologia Sperimentale, Universita degli Studi di Messina, Messina, Italy
J Immunol 181:566-73. 2008..neoformans. Our data demonstrate that type I IFN signaling is required for polarization of cytokine responses toward a protective type I pattern during cryptococcal infection...
- Plasmacytoid dendritic cell-derived type I interferon is crucial for the adjuvant activity of Toll-like receptor 7 agonistsDeepa Rajagopal
King s College London, Peter Gorer Department of Immunobiology, Guy s Hospital, London, United Kingdom
Blood 115:1949-57. 2010..This study, therefore, identifies sufficient IFN-alpha production by PDC as an important determinant of vaccine efficacy...
- Induction of IFN-alphabeta enables Listeria monocytogenes to suppress macrophage activation by IFN-gammaManira Rayamajhi
National Jewish Health, Denver, CO 80206, USA
J Exp Med 207:327-37. 2010..Furthermore, the increased resistance of mice lacking the IFN-alphabeta receptor (IFNAR(-/-)) to L...
- Conidia but not yeast cells of the fungal pathogen Histoplasma capsulatum trigger a type I interferon innate immune response in murine macrophagesDiane O Inglis
Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143 0414, USA
Infect Immun 78:3871-82. 2010..Interestingly, H. capsulatum growth was restricted in mice lacking the type I IFN receptor, indicating that an intact host type I IFN response is required for full virulence of H. capsulatum in mice...
- Signal 3 requirement for memory CD8+ T-cell activation is determined by the infectious pathogenSelina J Keppler
Institute for Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg, Freiburg, Germany
Eur J Immunol 41:3176-86. 2011..In summary, our results reveal an essential role for direct inflammatory cytokine signaling in secondary T-cell responses...
- The toll-like receptor 3-mediated antiviral response is important for protection against poliovirus infection in poliovirus receptor transgenic miceYuko Abe
Neurovirology Project, Tokyo Metropolitan Institute of Medical Science, 2 1 6 Kamikitazawa, Setagaya Ku, Tokyo 156 8506, Japan
J Virol 86:185-94. 2012..These results suggest that multiple pathways are involved in the antiviral response in mice and that the TLR3-TRIF-mediated signaling pathway plays an essential role in the antiviral response against PV infection...
- The negative costimulatory molecule PD-1 modulates the balance between immunity and tolerance via miR-21Dimitrios Iliopoulos
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
Eur J Immunol 41:1754-63. 2011....
- Type I IFN receptor signals directly stimulate local B cells early following influenza virus infectionElizabeth S Coro
Center for Comparative Medicine, University of California, Davis, 95616, USA
J Immunol 176:4343-51. 2006..Thus, ligand(s) of the type I IFNR are direct nonredundant early innate signals that regulate local antiviral B cell responses...
- Type I IFN regulate DC turnover in vivoFabrizio Mattei
Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
Eur J Immunol 39:1807-18. 2009..We found that DC, especially the CD8alpha(+) subset, from type I IFN receptor knock out (IFNAR KO) mice, display a reduced turnover rate when compared with DC from WT mice, as revealed by BrdU labelling ..
- Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNAG Uze
Laboratoire d Oncologie virale, CNRS UPR 274, Villejuif, France
Cell 60:225-34. 1990..Mouse cells expressing the cDNA become sensitive to the antiviral activity of and express binding sites for human interferon alpha, demonstrating that the cloned cDNA encodes a functional human interferon alpha receptor...
- Endogenous IFN-alpha beta suppresses colony-stimulating factor (CSF)-1-stimulated macrophage DNA synthesis and mediates inhibitory effects of lipopolysaccharide and TNF-alphaJ A Hamilton
Department of Medicine, University of Melbourne, The Royal Melbourne Hospital, Victoria, Australia
J Immunol 156:2553-7. 1996..it is proposed that the type I IFN receptor (IFNAR 1) "knockout" mice may be useful in delineating some of the in vivo actions of CSF-1, LPS, TNF-alpha, and possibly ..
- CD8(+) T cell-mediated skin disease in mice lacking IRF-2, the transcriptional attenuator of interferon-alpha/beta signalingS Hida
Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
Immunity 13:643-55. 2000..IRF-2 may represent a unique negative regulator, attenuating IFN-alpha/beta-induced gene transcription, which is necessary for balancing the beneficial and harmful effects of IFN-alpha/beta signaling in the immune system...
- A unique mechanism for innate cytokine promotion of T cell responses to viral infectionsGary C Pien
Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
J Immunol 169:5827-37. 2002..Because stimulation by microbial products is linked to innate cytokine expression, the studies also suggest a pathway for precisely limiting T cell functions to times of need...
- Identification of a TLR4- and TRIF-dependent activation program of dendritic cellsHeike Weighardt
Department of Surgery, Technical University Munich, Munich, Germany
Eur J Immunol 34:558-64. 2004..Together, these data therefore identify TRIF as a crucial regulator of TLR4-dependent dendritic cell responses...
- Both viral and host factors contribute to neurovirulence of bovine herpesviruses 1 and 5 in interferon receptor-deficient miceCarlos Abril
Institute of Virology Institute of Veterinary Pathology, University of Zurich, Zurich, Switzerland
J Virol 78:3644-53. 2004..We conclude that the alpha/beta interferon system had a protective effect, while an intact gamma interferon system was required for efficient replication of BHV-5 in mouse neurons and for the development of neurological disease...
- Monocyte chemoattractant protein-1 and CCR2 interactions are required for IFN-alpha/beta-induced inflammatory responses and antiviral defense in liverKirsten L Hokeness
Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
J Immunol 174:1549-56. 2005....
- TLR-dependent induction of IFN-beta mediates host defense against Trypanosoma cruziRitsuko Koga
Department of Molecular Genetics, Medical Institute of Bioregulation, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan
J Immunol 177:7059-66. 2006..Neutralization of IFN-beta in MyD88(-/-) macrophages led to enhanced T. cruzi growth. Cells from MyD88(-/-)IFNAR1(-/-) mice also showed impaired T. cruzi clearance...
- Antitumor NK activation induced by the Toll-like receptor 3-TICAM-1 (TRIF) pathway in myeloid dendritic cellsTakashi Akazawa
Department of Immunology, Osaka Medical Center for Cancer, Nakamichi 1 3 2, Higashinari ku, Osaka 537 8511, Japan
Proc Natl Acad Sci U S A 104:252-7. 2007..This NK-dependent tumor regression did not occur in TICAM-1(-/-) or IFNAR(-/-) mice, whereas a normal NK antitumor response was induced in PKR(-/-), MyD88(-/-), IFN-beta(-/-), and wild-..
- The feedback phase of type I interferon induction in dendritic cells requires interferon regulatory factor 8Prafullakumar Tailor
Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Immunity 27:228-39. 2007..Together, these data indicate that IRF8 magnifies the second phase of IFN transcription in DCs by prolonging binding of basic transcription machinery to the IFN promoters, thereby playing a role in innate immunity...
- TLR agonists promote marginal zone B cell activation and facilitate T-dependent IgM responsesAnatoly V Rubtsov
Integrated Department of Immunology, University of Colorado Denver and National Jewish Medical and Research Center, Denver, CO 80206, USA
J Immunol 180:3882-8. 2008..Together, these data demonstrate that in vivo TLR agonist treatment enhances the early production of Ag-specific IgM and activates MZ B cells to promote their relocation...
- Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN-beta induction via X-box binding protein 1Judith A Smith
William S Rowe Division of Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Eur J Immunol 38:1194-203. 2008....
- Bacterial endotoxin induces the release of high mobility group box 1 via the IFN-beta signaling pathwayJu Hyun Kim
Department of Pathology, Hallym University College of Medicine, Chuncheon, Korea
J Immunol 182:2458-66. 2009..Our results suggest that HMGB1 release in sepsis is dependent on the IFN-beta signaling axis; thus, therapeutic agents that selectively inhibit IFN-beta signaling could be beneficial in the treatment of sepsis...
- Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivoNelson C Di Paolo
Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA
Immunity 31:110-21. 2009..Thus, these data identify IL-1 alpha-IL-1RI as a key pathway allowing for the activation of proinflammatory responses to the virus, independently of its genomic nucleic acid recognition...
- Functional role of type I and type II interferons in antiviral defenseU Muller
Institute of Molecular Biology I, University of Zurich, Switzerland
Science 264:1918-21. 1994..Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant...
- Differential regulation of constitutive major histocompatibility complex class I expression in T and B lymphocytesC K Lee
Department of Pathology and Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, New York 10016, USA
J Exp Med 190:1451-64. 1999....
- Distinct requirements for IFNs and STAT1 in NK cell functionC K Lee
Department of Pathology, Kaplan Comprehensive Cancer Center, New York University School of Medicine, NY 10016, USA
J Immunol 165:3571-7. 2000..These results demonstrate that both IFN-alpha and IFN-gamma are required to maintain NK cell function and define a STAT1-dependent but partially IFN-independent pathway required for NK-mediated antitumor activity...
- Requirement for STAT1 in LPS-induced gene expression in macrophagesY Ohmori
Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Ohio 44195, USA
J Leukoc Biol 69:598-604. 2001....
- The role of the Type I interferon response in the resistance of mice to filovirus infectionM Bray
Department of Viral Therapeutics, Virology Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD 21702 5011, USA
J Gen Virol 82:1365-73. 2001..The outcome of filovirus transfer between animal species appears to be determined by interactions between the virus and the innate immune response...
- Critical role for alpha/beta and gamma interferons in persistence of lymphocytic choriomeningitis virus by clonal exhaustion of cytotoxic T cellsR Ou
Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
J Virol 75:8407-23. 2001..We discuss the role of IFNs in influencing virus-specific T cells that determine the outcome of persistent infections...
- IFN-alpha/beta enhances BCR-dependent B cell responsesDeborah Braun
Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, 2781 Oeiras, Portugal
Int Immunol 14:411-9. 2002....
- Production of type I IFN sensitizes macrophages to cell death induced by Listeria monocytogenesSilvia Stockinger
Vienna Biocenter and University of Vienna, Institute of Microbiology and Genetics, Austria
J Immunol 169:6522-9. 2002..The data stress the importance of type I IFN for the course of infections with intracellular bacteria and suggest that factors other than listeriolysin O contribute to macrophage death during Listeria infection...
- The tyrosine kinase Tyk2 controls IFNAR1 cell surface expressionJosiane Ragimbeau
Unité de Signalisation des Cytokines, CNRS URA 1961, Unite de Biologie des Interactions Cellulaires, CNRS URA 1960, Institut Pasteur, Paris 75724 Cedex 15, France
EMBO J 22:537-47. 2003..In the type I interferon receptor, Tyk2 associates with the IFNAR1 receptor subunit and positively influences ligand binding to the receptor complex...
- Cross-priming of CD8+ T cells stimulated by virus-induced type I interferonAgnes Le Bon
The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire RG20 7NN, England
Nat Immunol 4:1009-15. 2003..These data identify expression of IFN-alpha/beta as a mechanism for the induction of cross-priming during virus infections...
- The alpha/beta interferon response controls tissue tropism and pathogenicity of poliovirusMiki Ida-Hosonuma
Department of Microbiology and Immunology, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Tokyo 183 8526, Japan
J Virol 79:4460-9. 2005..in PVR-transgenic mice and PVR-transgenic mice deficient in the alpha/beta IFN receptor gene (PVR-transgenic/Ifnar knockout mice). PVR-transgenic/Ifnar knockout mice showed increased susceptibility to poliovirus...
- Type I IFNs provide a third signal to CD8 T cells to stimulate clonal expansion and differentiationJulie M Curtsinger
Department of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
J Immunol 174:4465-9. 2005..Provision of the third signal by either IFN-alpha beta or IL-12 results in regulation of the expression of a number of genes, including several that encode proteins critical for effector function...
- A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cellsGregory Gautier
Laboratory for Immunological Research, Schering Plough, 69571 Dardilly, France
J Exp Med 201:1435-46. 2005..Strikingly, IL-12p70 but not IL-12p40 secretion was strongly reduced in BM-DC from STAT1(-/-) and IFNAR(-/-) mice...
- Critical roles for both STAT1-dependent and STAT1-independent pathways in the control of primary dengue virus infection in miceSujan Shresta
Division of Infectious Diseases, School of Public Health, University of California, Berkeley, CA 94720, USA
J Immunol 175:3946-54. 2005..Collectively, these data begin to define the nature of the STAT1-dependent vs the STAT1-independent pathway in vivo...
- Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activityJennifer E Fenner
Centre for Functional Genomics and Human Disease, Monash Institute of Medical Research, Monash University, Clayton 3168, Australia
Nat Immunol 7:33-9. 2006..IFN-alpha and IFN-beta) and mice deficient in interferon-gamma or type I interferon receptor components (IFNAR1 or IFNAR2), we demonstrate here that SOCS1 deficiency amplified type I interferon antiviral and proinflammatory ..
- Cutting Edge: The direct action of type I IFN on CD4 T cells is critical for sustaining clonal expansion in response to a viral but not a bacterial infectionColin Havenar-Daughton
Department of Immunology and Washington National Primate Center, University of Washington, 1959 Northeast Pacific Street, Seattle, WA 98195, USA
J Immunol 176:3315-9. 2006..Thus, direct IFN-I signals can play either a critical or minimal role in CD4 T cell clonal expansion depending on the specific pathogen...
- Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activationSeiichi Kuwajima
Department of Immunology, Akita University School of Medicine, Akita 010 8543, Japan
Nat Immunol 7:740-6. 2006..Interaction between CD40 on cDCs and CD40 ligand on pDCs led to IL-12 production by cDCs. Thus, IL-15-dependent crosstalk between cDCs and pDCs is essential for CpG-induced immune activation...
- Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferonLuisa Cervantes-Barragan
Research Department, Kantonal Hospital St Gallen, Switzerland, and Abeteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, Germany
Blood 109:1131-7. 2007..Taken together, our results suggest that rapid production of type I IFNs by pDCs is essential for the control of potentially lethal coronavirus infections...
- Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophagesKohki Kawane
Department of Genetics, Osaka University, Osaka 565 0871, Japan
Nature 443:998-1002. 2006....
- Protective role of beta interferon in host defense against influenza A virusIris Koerner
Department of Virology, University of Freiburg, Hermann Herder Strasse 11, D 79104 Freiburg, Germany
J Virol 81:2025-30. 2007..Mx-wt) or mice carrying functional Mx1 alleles but lacking functional type I IFN receptors (designated Mx-IFNAR)...
- Innate immune response to adenoviral vectors is mediated by both Toll-like receptor-dependent and -independent pathwaysJiangao Zhu
Department of Medicine, Duke University Medical Center, Box 3502, Durham, NC 27710, USA
J Virol 81:3170-80. 2007..Our results that suggest strategies to interfere with type I IFN pathway may improve the outcome of adenovirus-mediated gene therapy, whereas approaches to activate the type I IFN pathway may enhance vaccine potency...
- TLR signaling fine-tunes anti-influenza B cell responses without regulating effector T cell responsesAlex K Heer
Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology, Zurich Schlieren, Switzerland
J Immunol 178:2182-91. 2007..Taken together, these data reveal that TLR signaling is not required for anti-influenza T cell responses, but through both direct and indirect means orchestrates appropriate anti-influenza B cell responses...
- Type I interferon signaling is required for activation of the inflammasome during Francisella infectionThomas Henry
Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
J Exp Med 204:987-94. 2007..This connection underscores the importance of the cytosolic recognition of pathogens and highlights how multiple innate immunity pathways interact before commitment to critical host responses...
- Establishment of a poliovirus oral infection system in human poliovirus receptor-expressing transgenic mice that are deficient in alpha/beta interferon receptorSeii Ohka
Department of Microbiology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
J Virol 81:7902-12. 2007..mice (Tg) carrying the human PV receptor (hPVR/CD155) gene and lacking the alpha/beta interferon receptor (IFNAR) gene (hPVR-Tg/IfnarKO) were sensitive to the oral administration of PV with 3% NaHCO3, whereas hPVR-Tg expressing ..
- Cutting edge: involvement of the type I IFN production and signaling pathway in lipopolysaccharide-induced IL-10 productionElmer Y Chang
Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095, USA
J Immunol 178:6705-9. 2007..Our findings suggest a novel anti-inflammatory role for the type I IFN production and signaling pathway in regulating LPS response in bone marrow-derived macrophages...
- MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsisMatthew J Delano
Department of Surgery, University of Florida College of Medicine, Gainesville, FL 32610, USA
J Exp Med 204:1463-74. 2007..GR-1(+)CD11b(+) cells contribute to sepsis-induced T cell suppression and preferential Th2 polarization...
- High basal STAT4 balanced by STAT1 induction to control type 1 interferon effects in natural killer cellsTakuya Miyagi
Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA
J Exp Med 204:2383-96. 2007....
- A conserved IFN-alpha receptor tyrosine motif directs the biological response to type I IFNsWenli Zhao
Department of Microbiology, Columbia University, New York, NY 10032, USA
J Immunol 180:5483-9. 2008..their potent biological activities through an evolutionarily conserved IFN-alpha receptor (IFNAR), consisting of IFNAR1 and IFNAR2...
- Type I IFNs enhance susceptibility to Chlamydia muridarum lung infection by enhancing apoptosis of local macrophagesHongyu Qiu
Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
J Immunol 181:2092-102. 2008..role of IFNIs in host resistance to chlamydial infection in vivo, we compared IFN-alpha/beta receptor knockout (IFNAR(-/-)) and wild-type control mice in susceptibility to Chlamydia trachomatis mouse pneumonitis (Chlamydia muridarum)..
- Murine coronavirus mouse hepatitis virus is recognized by MDA5 and induces type I interferon in brain macrophages/microgliaJessica K Roth-Cross
Department of Microbiology, University of Pennsylvania, School of Medicine, 36th Street and Hamilton Walk, Philadelphia, PA 19104 6076, USA
J Virol 82:9829-38. 2008..When infected with MHV, mice deficient in IFN-associated receptor expression (IFNAR(-/-)) became moribund by 48 h postinfection...
- Type I IFN-mediated protection of macrophages and dendritic cells secures control of murine coronavirus infectionLuisa Cervantes-Barragan
Research Department, Kantonal Hospital St Gallen, St Gallen, Switzerland
J Immunol 182:1099-106. 2009..Generation of bone marrow-chimeric mice expressing the type I IFN receptor (IFNAR) on either hemopoietic or non-bone marrow-derived cells revealed that the early control of MHV depended mainly on ..
- Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loopNathaniel M Green
Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA
J Immunol 183:1569-76. 2009..By contrast, IFNAR1(-/-) B cells did not produce cytokines, but did proliferate and up-regulate activation markers in response to ..
- VIRUSES AND AUTOIMMUNE DISEASEMichael Oldstone; Fiscal Year: 2001..The second order of business is to determine the role of "self" (islet-cell) antigens other than the initial triggering viral antigen in the pathogenetic process leading to and determine their role in IDDM. ..
- STUDIES OF A NEW MYELIN GENE THAT CAUSES CNS DISEASEMichael Oldstone; Fiscal Year: 2001..Their studies in rodents combined with those of their collaborator, Dr. Martin, should begin to characterize the role played by MONP in neurologic disease. ..
- Pathogenesis Studies in Scrapie (TSE Diseases)Michael Oldstone; Fiscal Year: 2003..This model should be useful to study pathophysiology of CWD as well as probing CWD strain differences. ..
- Viruses and DiabetesMichael Oldstone; Fiscal Year: 2005....
- MEASLES VIRUS STUDIES IN A TRANSGENIC MODELMichael Oldstone; Fiscal Year: 2007..abstract_text> ..
- Aging Disease--Prion/Transgenic/Immunologic StudiesMichael Oldstone; Fiscal Year: 2008..Lastly, Jose Criado will continue his electrophysiology and behavioral studies on the normal function of PrP and on its aberrations during TSE disease. ..
- Arenavirus Receptor-Structure/Function StudiesMichael B Oldstone; Fiscal Year: 2010..These findings have relevance for biodefense of several viruses including LFV. ..
- Therapeutics to Prevent/Treat Lassa Fever VirusMichael B Oldstone; Fiscal Year: 2010..We anticipate making a significant contribution to drug development to treat these BSL-4 agents. ..
- Anti-Tumor Autoimmunity by lymphopenia T cell ExpansionRoberto Baccala; Fiscal Year: 2008..The results will define the role of homeostatic T cell proliferation in tumor autoimmunity, and provide new approaches to the treatment of cancer. [unreadable] [unreadable]..
- Bacterial artificial chromosomes for HSV genomicsDavid Leib; Fiscal Year: 2004..abstract_text> ..
- A VEE Replicon-Based Vaccine for Dengue VirusLaura White; Fiscal Year: 2006..abstract_text> ..
- Recruitment of memory CD8+ T cells to the lung airwaysJACOB KOHLMEIER; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Development of Cellular Assays of Dengue Virus InfectionPriscilla Yang; Fiscal Year: 2008..These inhibitors can be used to study how dengue virus interacts with its host, and they may also be useful in developing therapies for the treatment of dengue virus infections. [unreadable] [unreadable] [unreadable]..