Ifnb1

Summary

Gene Symbol: Ifnb1
Description: interferon beta 1, fibroblast
Alias: IFN-beta, IFNB, Ifb, interferon beta
Species: mouse

Top Publications

  1. ncbi Interferon-beta is required for interferon-alpha production in mouse fibroblasts
    L Erlandsson
    Immunology Group, CMB, Lund University, Sweden
    Curr Biol 8:223-6. 1998
  2. pmc Impaired antiviral response and alpha/beta interferon induction in mice lacking beta interferon
    R Deonarain
    MRC Clinical Science Centre, Imperial College School of Medicine, Hammersmith Hospital, London W12 ONN, United Kingdom
    J Virol 74:3404-9. 2000
  3. ncbi The genetic control of sialadenitis versus arthritis in a NOD.QxB10.Q F2 cross
    Asa C M Johansson
    Section for Medical Inflammation Research, University of Lund, Lund, Sweden
    Eur J Immunol 32:243-50. 2002
  4. ncbi Type I interferons produced by dendritic cells promote their phenotypic and functional activation
    Maria Montoya
    Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, United Kingdom
    Blood 99:3263-71. 2002
  5. ncbi Cutting edge: a murine, IL-12-independent pathway of IFN-gamma induction by gram-negative bacteria based on STAT4 activation by Type I IFN and IL-18 signaling
    Marina A Freudenberg
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    J Immunol 169:1665-8. 2002
  6. pmc Innate recognition of bacteria by a macrophage cytosolic surveillance pathway
    MARY O'RIORDAN
    Department of Molecular and Cell Biology, School of Public Health, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 99:13861-6. 2002
  7. ncbi Production of type I IFN sensitizes macrophages to cell death induced by Listeria monocytogenes
    Silvia Stockinger
    Vienna Biocenter and University of Vienna, Institute of Microbiology and Genetics, Austria
    J Immunol 169:6522-9. 2002
  8. ncbi Upregulation of B7 molecules (CD80 and CD86) and exacerbated eosinophilic pulmonary inflammatory response in mice lacking the IFN-beta gene
    Victor Matheu
    Section for Medical Inflammation Research, Institute for Cell and Molecular Biology, Lund University, Lund, Sweden
    J Allergy Clin Immunol 111:550-7. 2003
  9. ncbi Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock
    Marina Karaghiosoff
    Institute of Animal Breeding and Genetics, Veterinary University of Vienna, A 1210 Vienna, Austria
    Nat Immunol 4:471-7. 2003
  10. ncbi IFN-beta gene deletion leads to augmented and chronic demyelinating experimental autoimmune encephalomyelitis
    Ingrid Teige
    Section for Medical Inflammation Research, Department of Cell and Molecular Biology, University of Lund, Lund, Sweden
    J Immunol 170:4776-84. 2003

Research Grants

  1. VIRUSES AND AUTOIMMUNE DISEASE
    Michael Oldstone; Fiscal Year: 2001
  2. STUDIES OF A NEW MYELIN GENE THAT CAUSES CNS DISEASE
    Michael Oldstone; Fiscal Year: 2001
  3. Pathogenesis Studies in Scrapie (TSE Diseases)
    Michael Oldstone; Fiscal Year: 2003
  4. Viruses and Diabetes
    Michael Oldstone; Fiscal Year: 2005
  5. MEASLES VIRUS STUDIES IN A TRANSGENIC MODEL
    Michael Oldstone; Fiscal Year: 2007
  6. Aging Disease--Prion/Transgenic/Immunologic Studies
    Michael Oldstone; Fiscal Year: 2008
  7. Arenavirus Receptor-Structure/Function Studies
    Michael B Oldstone; Fiscal Year: 2010
  8. Therapeutics to Prevent/Treat Lassa Fever Virus
    Michael B Oldstone; Fiscal Year: 2010
  9. NATURAL KILLER CELL TRAFFICKING AND DELIVERY OF FUNCTION
    THAIS SALAZAR MATHER; Fiscal Year: 2002
  10. Innate immune evasion and/or antagonism by eastern equine encephalitis virus
    KATHERINE RYMAN; Fiscal Year: 2007

Scientific Experts

Detail Information

Publications124 found, 100 shown here

  1. ncbi Interferon-beta is required for interferon-alpha production in mouse fibroblasts
    L Erlandsson
    Immunology Group, CMB, Lund University, Sweden
    Curr Biol 8:223-6. 1998
    ..These results imply a unique role for IFN-beta in the induction of type I interferons in peripheral tissues...
  2. pmc Impaired antiviral response and alpha/beta interferon induction in mice lacking beta interferon
    R Deonarain
    MRC Clinical Science Centre, Imperial College School of Medicine, Hammersmith Hospital, London W12 ONN, United Kingdom
    J Virol 74:3404-9. 2000
    ..Furthermore, in cultured embryo fibroblasts, viral induction of alpha interferon and of 2-5A synthetase genes is impaired. We also show that beta interferon does not prime its own expression...
  3. ncbi The genetic control of sialadenitis versus arthritis in a NOD.QxB10.Q F2 cross
    Asa C M Johansson
    Section for Medical Inflammation Research, University of Lund, Lund, Sweden
    Eur J Immunol 32:243-50. 2002
    ..The genetic control of sialadenitis seemed to be unique in comparison to diabetes and arthritis, as no loci associated with these diseases have been identified at the same location...
  4. ncbi Type I interferons produced by dendritic cells promote their phenotypic and functional activation
    Maria Montoya
    Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, United Kingdom
    Blood 99:3263-71. 2002
    ..These results show that DCs both secrete and respond to type I IFN, identifying type I interferons as autocrine DC activators...
  5. ncbi Cutting edge: a murine, IL-12-independent pathway of IFN-gamma induction by gram-negative bacteria based on STAT4 activation by Type I IFN and IL-18 signaling
    Marina A Freudenberg
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    J Immunol 169:1665-8. 2002
    ..This pathway participates in the induction of IFN-gamma by Gram-negative bacteria and is therefore expected to play a role whenever IFN-alpha or IFN-beta and IL-18 are produced concomitantly during bacterial, viral, or other infections...
  6. pmc Innate recognition of bacteria by a macrophage cytosolic surveillance pathway
    MARY O'RIORDAN
    Department of Molecular and Cell Biology, School of Public Health, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 99:13861-6. 2002
    ..of Gram-positive and Gram-negative bacterial products by this surveillance system results in transcription of the ifnb gene...
  7. ncbi Production of type I IFN sensitizes macrophages to cell death induced by Listeria monocytogenes
    Silvia Stockinger
    Vienna Biocenter and University of Vienna, Institute of Microbiology and Genetics, Austria
    J Immunol 169:6522-9. 2002
    ..The data stress the importance of type I IFN for the course of infections with intracellular bacteria and suggest that factors other than listeriolysin O contribute to macrophage death during Listeria infection...
  8. ncbi Upregulation of B7 molecules (CD80 and CD86) and exacerbated eosinophilic pulmonary inflammatory response in mice lacking the IFN-beta gene
    Victor Matheu
    Section for Medical Inflammation Research, Institute for Cell and Molecular Biology, Lund University, Lund, Sweden
    J Allergy Clin Immunol 111:550-7. 2003
    ..Some reports attributed its beneficial effects to the capacity to induce a T(H)2 response. However, other studies have suggested that endogenous type I IFN might downregulate the allergic response in mice...
  9. ncbi Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock
    Marina Karaghiosoff
    Institute of Animal Breeding and Genetics, Veterinary University of Vienna, A 1210 Vienna, Austria
    Nat Immunol 4:471-7. 2003
    ..IFN-beta-null but not STAT1-null mice were also resistant to high dose LPS treatment. Together, these data suggest that Tyk2 and IFN-beta are essential effectors in LPS induced lethality...
  10. ncbi IFN-beta gene deletion leads to augmented and chronic demyelinating experimental autoimmune encephalomyelitis
    Ingrid Teige
    Section for Medical Inflammation Research, Department of Cell and Molecular Biology, University of Lund, Lund, Sweden
    J Immunol 170:4776-84. 2003
    ..We suggest that lack of endogenous IFN-beta in CNS leads to augmented microglia activation, resulting in a sustained inflammation, cytokine production, and tissue damage with consequent chronic neurological deficits...
  11. pmc Critical roles for IFN-beta in lymphoid development, myelopoiesis, and tumor development: links to tumor necrosis factor alpha
    Raj Deonarain
    Toronto General Research Institute, University Health Network, Toronto, ON, Canada MG5 2M1
    Proc Natl Acad Sci U S A 100:13453-8. 2003
    ..Taken altogether, our data suggest that, in addition to the direct growth-inhibitory effects on tumor cells, IFN-beta is required during different stages of maturation in the development of the immune system...
  12. pmc Negative regulation of IFN-alpha/beta signaling by IFN regulatory factor 2 for homeostatic development of dendritic cells
    Kenya Honda
    Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 101:2416-21. 2004
    ....
  13. ncbi Protection against progressive leishmaniasis by IFN-beta
    Jochen Mattner
    Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen Nuremberg, Erlangen, Germany
    J Immunol 172:7574-82. 2004
    ..These results identify IFN-beta as a novel cytokine with a strong, dose-dependent protective effect against progressive cutaneous leishmaniasis that results from IL-12- and STAT4-dependent as well as -independent events...
  14. ncbi Type I IFN protects permissive macrophages from Legionella pneumophila infection through an IFN-gamma-independent pathway
    Giovanna Schiavoni
    Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy
    J Immunol 173:1266-75. 2004
    ..pneumophila infection in mouse models of susceptible macrophages and suggest the existence of different pathways for the control of intracellular bacteria in macrophages...
  15. ncbi Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-beta
    Tomonori Hirotani
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 328:383-92. 2005
    ..Genes known to be induced by type I interferons were simply dependent on TRIF for their expression. Taken together, MyD88 and TRIF play both redundant and distinct roles in LPS-induced gene expression...
  16. ncbi IRF-7 is the master regulator of type-I interferon-dependent immune responses
    Kenya Honda
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 434:772-7. 2005
    ..Thus, all elements of IFN responses, whether the systemic production of IFN in innate immunity or the local action of IFN from plasmacytoid dendritic cells in adaptive immunity, are under the control of IRF-7...
  17. ncbi Listeria-infected myeloid dendritic cells produce IFN-beta, priming T cell activation
    Hanping Feng
    CBR Institute for Biomedical Research and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 175:421-32. 2005
    ..Exposure to high concentrations of IFN-beta sensitizes naive T cells for Ag-dependent activation...
  18. ncbi Novel functions of tyrosine kinase 2 in the antiviral defense against murine cytomegalovirus
    Birgit Strobl
    Institute of Animal Breeding and Genetics, Veterinary University of Vienna, Vienna, Austria
    J Immunol 175:4000-8. 2005
    ..In addition to the established role of Tyk2 as an amplifier of Jak/Stat signaling upon IFN-alphabeta stimulation, we provide evidence for a novel role of Tyk2 as a modifier of host responses...
  19. ncbi Regulation of the type I IFN induction: a current view
    Kenya Honda
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Int Immunol 17:1367-78. 2005
    ..The understanding of the regulatory mechanisms of IFN-alpha/beta gene induction by TLRs and viruses is an emerging theme, for which much new insight has been gained over the past few years...
  20. ncbi Contribution of interferon-beta to the murine macrophage response to the toll-like receptor 4 agonist, lipopolysaccharide
    Karen E Thomas
    Department of Microbiology and Immunology, University of Maryland, Baltimore, Maryland 21201, USA
    J Biol Chem 281:31119-30. 2006
    ..g. TLR4(-/-) or TRIF(-/-) mice). Collectively, these findings reveal unanticipated regulatory roles for IFN-beta in response to LPS in vitro and in vivo...
  21. ncbi TLR-dependent induction of IFN-beta mediates host defense against Trypanosoma cruzi
    Ritsuko Koga
    Department of Molecular Genetics, Medical Institute of Bioregulation, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Immunol 177:7059-66. 2006
    ..cruzi. These findings suggest that TLR-dependent expression of IFN-beta is involved in resistance to T. cruzi infection through the induction of IRG47...
  22. ncbi Type I IFN signaling is crucial for host resistance against different species of pathogenic bacteria
    Giuseppe Mancuso
    Dipartimento di Patologia e Microbiologia Sperimentale, Universita degli Studi di Messina, Via Consolare Valeria 1, 98125 Messina, Italy
    J Immunol 178:3126-33. 2007
    ..These data may be useful to devise alternative strategies to treat bacterial infections...
  23. pmc NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs
    Ulrike Schleicher
    Institute of Medical Microbiology and Hygiene, University of Freiburg, D 79104 Freiburg, Germany
    J Exp Med 204:893-906. 2007
    ....
  24. ncbi Cutting edge: involvement of the type I IFN production and signaling pathway in lipopolysaccharide-induced IL-10 production
    Elmer Y Chang
    Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095, USA
    J Immunol 178:6705-9. 2007
    ..Our findings suggest a novel anti-inflammatory role for the type I IFN production and signaling pathway in regulating LPS response in bone marrow-derived macrophages...
  25. ncbi TAM receptors are pleiotropic inhibitors of the innate immune response
    Carla V Rothlin
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Cell 131:1124-36. 2007
    ....
  26. ncbi IFN-beta increases listeriolysin O-induced membrane permeabilization and death of macrophages
    Heather Zwaferink
    Max F Perutz Laboratories, Vienna Biocenter, Department of Microbiology and Immunobiology, University of Vienna, Vienna, Austria
    J Immunol 180:4116-23. 2008
    ..Key lipogenesis enzymes were suppressed in IFN-beta-treated cells, which may exacerbate the membrane damage caused by LLO...
  27. pmc Visualization of IFNbeta production by plasmacytoid versus conventional dendritic cells under specific stimulation conditions in vivo
    Stefanie Scheu
    Institute of Medical Microbiology and Hospital Hygiene, Universitat Dusseldorf, Universitatsstrasse 1, 40225 Dusseldorf, Germany
    Proc Natl Acad Sci U S A 105:20416-21. 2008
    ..This IFNbeta/YFP reporter mouse represents a reliable tool for the visualization and characterization of IFNbeta-producing cells in vitro and in vivo...
  28. pmc TLR4 ligands induce IFN-alpha production by mouse conventional dendritic cells and human monocytes after IFN-beta priming
    Christophe Richez
    Renal Section, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 182:820-8. 2009
    ..This data demonstrates a novel pathway for IFN-alpha production by cDCs and provides one possible explanation for how bacterial infection might precipitate disease flares in SLE...
  29. doi Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells
    Giuseppe Mancuso
    The Elie Metchnikoff Department, University of Messina, Messina, Italy
    Nat Immunol 10:587-94. 2009
    ..Thus, this cell type-specific recognition pathway links lysosomal recognition of bacterial RNA with a robust, host-protective interferon response...
  30. doi Novel reporter mouse reveals constitutive and inflammatory expression of IFN-beta in vivo
    Stefan Lienenklaus
    Molecular Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    J Immunol 183:3229-36. 2009
    ..This relatively high constitutive expression was controlled by the NF Aire and might influence induction of tolerance or T cell development...
  31. doi Regulatory effects of IFN-beta on production of osteopontin and IL-17 by CD4+ T Cells in MS
    Meiyue Chen
    Multiple Sclerosis Research Unit, Department of Neurology and Baylor Multiple Sclerosis Center, Baylor College of Medicine, Houston, TX 77030, USA
    Eur J Immunol 39:2525-36. 2009
    ..This study provides new insights into the mechanism of action of IFN-beta in the treatment of MS...
  32. pmc Induction of IFN-beta and the innate antiviral response in myeloid cells occurs through an IPS-1-dependent signal that does not require IRF-3 and IRF-7
    Stephane Daffis
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Pathog 5:e1000607. 2009
    ....
  33. pmc Stimulator of IFN gene is critical for induction of IFN-beta during Chlamydia muridarum infection
    Daniel Prantner
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Immunol 184:2551-60. 2010
    ....
  34. doi Critical role of IkappaB Kinase alpha in TLR7/9-induced type I IFN production by conventional dendritic cells
    Katsuaki Hoshino
    Laboratory for Host Defense, RIKEN Research Center for Allergy and Immunology, Graduate School of Nanobioscience, Yokohama City University, Yokohama, Japan
    J Immunol 184:3341-5. 2010
    ..Our results show that IKKalpha is a unique molecule involved in TLR7/9-MyD88-dependent type I IFN production through DC subset-specific mechanisms...
  35. pmc Murine toll-like receptor 2 activation induces type I interferon responses from endolysosomal compartments
    Nicole Dietrich
    Molecular Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    PLoS ONE 5:e10250. 2010
    ..Until now, TLR2 activation by bacterial ligands has long been associated with pro-inflammatory cytokines but not type I interferon responses...
  36. pmc A fluorescence reporter model defines "Tip-DCs" as the cellular source of interferon β in murine listeriosis
    Philipp Dresing
    Institute of Medical Microbiology and Hospital Hygiene, University of Dusseldorf, Dusseldorf, Germany
    PLoS ONE 5:e15567. 2010
    ..reporter-knockin mouse model in which YFP is expressed from a bicistronic mRNA linked by an IRES to the endogenous ifnb mRNA to assess the IFNβ production on a single cell level in situ...
  37. pmc Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis
    Mathieu Blanc
    Division of Pathway Medicine and Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Biol 9:e1000598. 2011
    ..These findings bring a new link between sterol metabolism and interferon antiviral response and support the idea of using host metabolic modifiers of innate immunity as a potential antiviral strategy...
  38. doi STAT4 is required for IFN-β-induced MCP-1 mRNA expression in murine mast cells
    Kazuma Iida
    Department of Molecular Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan
    Int Arch Allergy Immunol 155:71-6. 2011
    ..However, it is still largely unknown whether signal transducers and activators of transcription 4 (STAT4), one of the STAT proteins under type I IFN signaling, is involved in type I IFN-mediated gene expression in mast cells...
  39. doi MyD88 drives the IFN-β response to Lactobacillus acidophilus in dendritic cells through a mechanism involving IRF1, IRF3, and IRF7
    Gudrun Weiss
    Department of Basic Sciences and Environment, Molecular Immunology, Faculty of Life Sciences, University of Copenhagen, 1871 Frederiksberg, Denmark
    J Immunol 189:2860-8. 2012
    ..acidophilus induces IFN-β independently of the receptors typically used by bacteria, as it requires MyD88, Syk, and PI3K signaling and phagosomal processing to activate IRF1 and IRF3/IRF7 and thereby the release of IFN-β...
  40. pmc Failure to induce IFN-β production during Staphylococcus aureus infection contributes to pathogenicity
    Amber Kaplan
    Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Immunol 189:4537-45. 2012
    ..aureus infection (in vitro and in vivo) was protective. Together, the data demonstrate that failure to induce IFN-β production during S. aureus infection contributes to pathogenicity...
  41. doi Structural basis of a unique interferon-β signaling axis mediated via the receptor IFNAR1
    Nicole A de Weerd
    Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia
    Nat Immunol 14:901-7. 2013
    ..Thus, we provide a molecular basis for understanding specific functions of IFN-β. ..
  42. ncbi Issues in T-helper 1 development--resolved and unresolved
    Lisa S Berenson
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunol Rev 202:157-74. 2004
    ..None of these areas is static or resolved fully, and they likely will remain topics of rapid progress...
  43. pmc Type I interferon signaling is required for activation of the inflammasome during Francisella infection
    Thomas Henry
    Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
    J Exp Med 204:987-94. 2007
    ..This connection underscores the importance of the cytosolic recognition of pathogens and highlights how multiple innate immunity pathways interact before commitment to critical host responses...
  44. ncbi Mouse microsatellites from a flow-sorted 4:6 Robertsonian chromosome
    R J Cornall
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, UK
    Mamm Genome 3:620-4. 1992
    ..Eight (62%) of the 13 repeats that have been mapped lie on Chromosomes (Chr) 4 and 6. This approach is an effective way of generating informative markers on specific chromosomes...
  45. ncbi The serine/threonine phosphatase inhibitor, calyculin A, inhibits and dissociates macrophage responses to lipopolysaccharide
    S A Barber
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Immunol 155:1404-10. 1995
    ..The requirement for a "late" phosphatase activity for expression of a subset of LPS-inducible genes dissociates at least two regulatory pathways in LPS signal transduction...
  46. ncbi Effects of interferon-beta on the cytokine production of astrocytes
    Kazumasa Okada
    Department of Neurology, School of Medicine, University of Occupational and Environmental Health, Yahatanishiku, Kitakyushu 807 8555, Japan
    J Neuroimmunol 159:48-54. 2005
    ..IFN-gamma augmented the effect of IFN-beta on IL-6 production. These results suggest that IFN-beta has an activity to modulate inflammatory and immune responses by up-regulating IL-6 in the CNS of MS...
  47. ncbi Chlamydia trachomatis induces expression of IFN-gamma-inducible protein 10 and IFN-beta independent of TLR2 and TLR4, but largely dependent on MyD88
    Uma M Nagarajan
    Division of Pediatric Infectious Diseases, Arkansas Children s Hospital, Little Rock, AR 72202, USA
    J Immunol 175:450-60. 2005
    ..Furthermore, the intracellular pathways that lead to chlamydial-induced IFN-beta function through TANK-binding kinase mediated phosphorylation and nuclear translocation of IFN regulatory factor-3...
  48. doi Prominent role for plasmacytoid dendritic cells in mucosal T cell-independent IgA induction
    Hiroyuki Tezuka
    Department of Biodefense Research, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Immunity 34:247-57. 2011
    ..Our findings provide insight into the molecular basis of pDC conditioning to induce mucosal TI IgA production, which may lead to improvements in vaccination strategies and treatment for mucosal-related disorders...
  49. pmc Type I IFN promotes IL-10 production from T cells to suppress Th17 cells and Th17-associated autoimmune inflammation
    Lixia Zhang
    Department of Microbiology and Immunology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, United States of America
    PLoS ONE 6:e28432. 2011
    ..Together, results from this study suggest that IFNβ may induce antigen-specific T cells to produce IL-10, which in turn negatively regulate Th17-mediate inflammatory and autoimmune response...
  50. pmc Activation of Oas1a gene expression by type I IFN requires both STAT1 and STAT2 while only STAT2 is required for Oas1b activation
    Joanna A Pulit-Penaloza
    Department of Biology, Georgia State University, Atlanta, GA 30302, USA
    Virology 425:71-81. 2012
    ..elements regulating gene transcription confirmed that an IFN-stimulated response element (ISRE) is required for IFN beta-activation but neither the overlapping IRF binding site present in both promoters nor the adjacent Oas1b NF-kappa ..
  51. pmc Beta interferon regulation of glucose metabolism is PI3K/Akt dependent and important for antiviral activity against coxsackievirus B3
    J D Burke
    Toronto General Research Institute, University Health Network, and Department of Immunology, University of Toronto, Toronto, Canada
    J Virol 88:3485-95. 2014
    ....
  52. pmc Type-I interferon signaling through ISGF3 complex is required for sustained Rip3 activation and necroptosis in macrophages
    Scott McComb
    Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada K1N 6N5 Department of Oncology, University Children s Hospital, University of Zurich, 8032 Zurich, Switzerland
    Proc Natl Acad Sci U S A 111:E3206-13. 2014
    ..Induction of IFNAR1/Rip3-dependent necroptosis also resulted in potent inflammatory pathology in vivo. These results reveal how IFN-I mediates acute inflammation through macrophage necroptosis. ..
  53. pmc Baculovirus induces type I interferon production through toll-like receptor-dependent and -independent pathways in a cell-type-specific manner
    Takayuki Abe
    Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    J Virol 83:7629-40. 2009
    ..These results suggest that a novel signaling pathway(s) other than TLR- and IPS-1-dependent pathways participates in the production of type I IFN in response to AcNPV infection...
  54. doi Calcineurin subunit B upregulates β-interferon production by phosphorylation of interferon regulatory factor 3 via Toll-like receptor 4
    Xinyu Wang
    Department of Biochemistry and Molecular Biology, Beijing Normal University, Beijing Key Laboratory, Beijing, China
    Cancer Sci 103:515-21. 2012
    ..In addition to pro-inflammatory cytokines, transcription and production of β-interferon were also enhanced after CNB stimulation. Thus, CNB could be further explored as a cancer and virus immunotherapy drug...
  55. doi IFNβ produced by TLR4-activated tumor cells is involved in improving the antitumoral immune response
    Nicolás Gonzalo Núñez
    Centro de Investigaciones en Bioquimica Clinica e Inmunologia, CIBICI CONICET, Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba, Argentina
    Cancer Res 72:592-603. 2012
    ..Together, our findings show that tumor cells can be induced through the TLR4 pathway to produce IFN and positively contribute to the antitumoral immune response...
  56. doi The protective effects of lactoferrin against murine norovirus infection through inhibition of both viral attachment and replication
    Hiroki Ishikawa
    Department of Microbiology, Tokyo Medical University, Tokyo 160 8402, Japan
    Biochem Biophys Res Commun 434:791-6. 2013
    ..The present results provide evidence that lactoferrin may be useful as a preventive and/or therapeutic anti-norovirus agent...
  57. pmc Three-dimensional crystal structure of recombinant murine interferon-beta
    T Senda
    Faculty of Engineering, Nagaoka University of Technology, Niigata, Japan
    EMBO J 11:3193-201. 1992
    ....
  58. ncbi Assignment of 12 loci to rat chromosome 5: evidence that this chromosome is homologous to mouse chromosome 4 and to human chromosomes 9 and 1 (1p arm)
    C Szpirer
    Universite Libre de Bruxelles, Departement de Biologie Moleculaire, Rhode St Genese, Belgium
    Genomics 6:679-84. 1990
    ..GGTB2), glucose transporter (GLUT1), interferon alpha 1 and related interferon alpha (INFA), interferon beta (INFB), lymphocyte-specific protein-tyrosine kinase (LCK), oncogene MOS, alpha 2U-globulin (major urinary ..
  59. ncbi Purification and carbohydrate structure of natural murine interferon-beta
    A Civas
    Unité Associée 040622 du Centre National de la Recherche Scientifique, Université de Paris XI, Chatenay Malabry, France
    Eur J Biochem 173:311-6. 1988
    ..These results when compared with data on N-glycans suggest the following structure for the carbohydrate moiety of Mu-INF-beta: (formula; see text)...
  60. pmc Transgenic mice in the study of cytokine function
    J Taverne
    University College London Medical School, Department of Immunology, UK
    Int J Exp Pathol 74:525-46. 1993
  61. ncbi Evidence from transgenic mice that interferon-beta may be involved in the onset of diabetes mellitus
    M Pelegrin
    Departament de Bioquimica i Biologia Molecular, Facultat de Veterinaria, Universitat Autonoma de Barcelona, 08193 Bellaterra, Spain
    J Biol Chem 273:12332-40. 1998
    ..These results suggest that IFN-beta may be involved in the onset of type 1 diabetes when combined with either an additional factor or a susceptible genetic background...
  62. pmc Type I interferons regulate inflammatory cell trafficking and macrophage inflammatory protein 1alpha delivery to the liver
    Thais P Salazar-Mather
    Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
    J Clin Invest 110:321-30. 2002
    ....
  63. ncbi Subcellular trafficking of exogenously expressed interferon-beta in Madin-Darby canine kidney cells
    Masato Maruyama
    Department of Biopharmaceutics and Drug Metabolism, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto, Japan
    J Cell Physiol 201:117-25. 2004
    ..These results suggest that stably and transiently expressed IFN-betas, albeit co-localized at TGN, were transported through apparently discriminated post-TGN routes...
  64. ncbi Exogenous expression of interferon-beta in cultured brain microvessel endothelial cells
    Masaru Nakamura
    Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Biol Pharm Bull 27:1441-3. 2004
    ..These findings provide important basic information about therapeutic secretory protein gene delivery to BMECs...
  65. ncbi Diversity and relatedness among the type I interferons
    Jiabing Chen
    Toronto General Research Institute, University Health Network and Department of Immunology, University of Toronto, Ontario, Canada
    J Interferon Cytokine Res 24:687-98. 2004
    ....
  66. pmc Basal and reovirus-induced beta interferon (IFN-beta) and IFN-beta-stimulated gene expression are cell type specific in the cardiac protective response
    Michael J Stewart
    Department of Molecular Biological Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    J Virol 79:2979-87. 2005
    ....
  67. ncbi IFN-beta-mediated up-regulation of CD1d in bacteria-infected APCs
    Gayatri Raghuraman
    Department of Pathology, University of Chicago, 924 East 57th Street, Chicago, IL 60637, USA
    J Immunol 177:7841-8. 2006
    ..Taken together, these data support a role for early IFN-beta-mediated up-regulation of CD1d in NKT cell activation during infection...
  68. pmc Protective role of beta interferon in host defense against influenza A virus
    Iris Koerner
    Department of Virology, University of Freiburg, Hermann Herder Strasse 11, D 79104 Freiburg, Germany
    J Virol 81:2025-30. 2007
    ....
  69. pmc Bacterial ligands generated in a phagosome are targets of the cytosolic innate immune system
    Anat A Herskovits
    Department of Molecular and Cell Biology, University of California, Berkeley, California, United States of America
    PLoS Pathog 3:e51. 2007
    ..This study supports the hypothesis that in activated macrophages, cytosolic innate immune receptors are activated by bacterial ligands generated in the phagosome and transported to the cytosol...
  70. ncbi Antiviral and myocyte protective effects of murine interferon-beta and -{alpha}2 in coxsackievirus B3-induced myocarditis and epicarditis in Balb/c mice
    Yi Xin Wang
    Berlex Biosciences, Richmond, CA, USA
    Am J Physiol Heart Circ Physiol 293:H69-76. 2007
    ..However, the potential mechanisms leading to a differential host response for the two isoforms of mIFN remain to be elucidated...
  71. ncbi Divergent roles of IFNs in the sensitization to endotoxin shock by lactate dehydrogenase-elevating virus
    Thao Le-Thi-Phuong
    Unit of Experimental Medicine, Universite Catholique de Louvain, UCL MEXP 7430, 1200 Bruxelles, Belgium
    Int Immunol 19:1303-11. 2007
    ..In sharp contrast with other viral infections, IFN-alpha/beta diminished IFN-gamma production and the resulting increased response to LPS in LDV-infected animals...
  72. ncbi The ubiquitin-mediated degradation of Jak1 modulates osteoclastogenesis by limiting interferon-beta-induced inhibitory signaling
    Youngkyun Lee
    Department of Cell and Developmental Biology, Dental Research Institute, School of Dentistry, Seoul National University, Korea
    Blood 111:885-93. 2008
    ..These data suggest that the regulation of Jak1 expression during osteoclast differentiation might serve as an intrinsic mechanism that determines osteoclast lineage commitment by modulating the negative regulation by IFN-beta...
  73. ncbi Stimulation by TLR5 modulates osteoclast differentiation through STAT1/IFN-beta
    Hyunil Ha
    Department of Cell and Developmental Biology, Dental Research Institute, School of Dentistry, Seoul National University, 28 Yeongon dong, Jongro Gu, Seoul, Republic of Korea
    J Immunol 180:1382-9. 2008
    ..In contrast, flagellin stimulated osteoclast differentiation in cocultures of osteoblasts and bone marrow cells without inducing IFN-beta. Thus, IFN-beta acts as a critical modulator of osteoclastogenesis in response to TLR5 activation...
  74. pmc IFN-beta sensitizes neuroblastoma to the antitumor activity of temozolomide by modulating O6-methylguanine DNA methyltransferase expression
    Shannon F Rosati
    Department of Surgery, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Mol Cancer Ther 7:3852-8. 2008
    ..Thus, IFN-beta and temozolomide may be a useful combination for treating children with this difficult disease...
  75. doi Bacterial endotoxin induces the release of high mobility group box 1 via the IFN-beta signaling pathway
    Ju Hyun Kim
    Department of Pathology, Hallym University College of Medicine, Chuncheon, Korea
    J Immunol 182:2458-66. 2009
    ..Our results suggest that HMGB1 release in sepsis is dependent on the IFN-beta signaling axis; thus, therapeutic agents that selectively inhibit IFN-beta signaling could be beneficial in the treatment of sepsis...
  76. pmc Regulation of inflammatory monocyte/macrophage recruitment from the bone marrow during murine cytomegalovirus infection: role for type I interferons in localized induction of CCR2 ligands
    Meredith J Crane
    Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    J Immunol 183:2810-7. 2009
    ....
  77. pmc XBP-1 couples endoplasmic reticulum stress to augmented IFN-beta induction via a cis-acting enhancer in macrophages
    Ling Zeng
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    J Immunol 185:2324-30. 2010
    ..recruitment of IFN regulatory factor-3, CREB binding protein/p300, and transcriptional machinery to the murine ifnb1 promoter during LPS stimulation...
  78. doi TLR4 through IFN-β promotes low molecular mass hyaluronan-induced neutrophil apoptosis
    Shaw Wei Leu
    Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    J Immunol 186:556-62. 2011
    ..Thus, TLR4 plays a novel homeostatic role in noninfectious lung inflammation by accelerating the elimination of inflammatory neutrophils...
  79. pmc Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons
    Josh Gregorio
    Department of Immunology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Med 207:2921-30. 2010
    ..These data uncover a new role of pDCs in sensing tissue damage and promoting wound repair at skin surfaces...
  80. pmc Regulation of effector and memory T-cell functions by type I interferon
    Jonathan P Huber
    Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9093, USA
    Immunology 132:466-74. 2011
    ..Moreover, IFN-α/β also serves as a counter-regulator of T helper type 2 and type 17 responses, which may be important in the treatment of atopy and autoimmunity, and in the development of novel vaccine adjuvants...
  81. pmc Type I interferons increase host susceptibility to Trypanosoma cruzi infection
    Anne Danielle C Chessler
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Building I, Rm 817, 665 Huntington Avenue, Boston, MA 02115, USA
    Infect Immun 79:2112-9. 2011
    ..These findings are consistent with a growing theme in the microbial pathogenesis field in which type I IFNs can be detrimental to the host in a variety of nonviral pathogen infection models...
  82. pmc Regulatory effects of IFN-β on the development of experimental autoimmune uveoretinitis in B10RIII mice
    Min Sun
    The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, People s Republic of China
    PLoS ONE 6:e19870. 2011
    ..IFN-β has been used in the treatment of certain autoimmune diseases. Earlier studies showed that it ameliorated EAU; however, the mechanisms involved in this inhibition are still largely unknown...
  83. pmc Posttranscriptional control of type I interferon genes by KSRP in the innate immune response against viral infection
    Wei Jye Lin
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Mol Cell Biol 31:3196-207. 2011
    ..protein (KSRP), an RNA-binding protein required for ARE-mediated mRNA decay, produce higher levels of Ifna and Ifnb mRNAs in response to viral infection as a result of decreased mRNA decay...
  84. pmc MyD88 and STING signaling pathways are required for IRF3-mediated IFN-β induction in response to Brucella abortus infection
    Leonardo A de Almeida
    Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte Minas Gerais, Brazil
    PLoS ONE 6:e23135. 2011
    ..This resistance phenotype is accompanied by increased IFN-γ and NO production by IFN-αβR KO spleen cells and reduced apoptosis...
  85. pmc Polyubiquitin binding to optineurin is required for optimal activation of TANK-binding kinase 1 and production of interferon β
    Catherine E Gleason
    Medical Research Council Protein Phosphorylation Unit, The Sir James Black Centre, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    J Biol Chem 286:35663-74. 2011
    ..In conclusion, our results suggest that OPTN binds to polyubiquitylated species formed in response to LPS and poly(I:C), enhancing the activation of TBK1 that is required for optimal phosphorylation of IRF3 and production of IFNβ...
  86. ncbi Contributions of recent research to the classification of spontaneous lymphoid cell neoplasms in mice
    P K Pattengale
    Crit Rev Toxicol 16:185-212. 1986
    ....
  87. ncbi IFN-gamma and IFN-beta independently stimulate the expression of lipopolysaccharide-inducible genes in murine peritoneal macrophages
    T A Hamilton
    Research Institute, Cleveland Clinic Foundation, OH 44195
    J Immunol 142:2325-31. 1989
    ..The spectrum of stimuli and cell types which express these and other early genes suggest that they may play an important role in orchestration of the inflammatory response...
  88. ncbi Induction of endogenous IFN-alpha and IFN-beta genes by a regulatory transcription factor, IRF-1
    T Fujita
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Nature 337:270-2. 1989
    ..This may be the first demonstration of the specific induction of silent chromosomal genes by transfection of a single transcription factor gene in mammalian cells...
  89. pmc Rearrangement of genes located on homologous chromosomal segments in mouse and man: the location of genes for alpha- and beta-interferon, alpha-1 acid glycoprotein-1 and -2, and aminolevulinate dehydratase on mouse chromosome 4
    J H Nadeau
    Genetics 114:1239-55. 1986
    Gene mapping studies to determine the order of alpha- and beta-interferon (Ifa, Ifb), aminolevulinate dehydratase (Lv), and alpha-1 acid glycoprotein-1 and -2 (Orm-1, Orm-2) relative to each other and to the reference genes brown (b), B-..
  90. ncbi Mouse interferon alpha and beta genes are linked at the centromere proximal region of chromosome 4
    J A van der Korput
    J Gen Virol 66:493-502. 1985
    ..Analysis of DNA from hybrids that contained only part of chromosome 4 indicated that the MuIFN-alpha gene family and the MuIFN-beta gene are situated at the centromere-proximal region of the chromosome...
  91. ncbi Structure and expression of a cloned cDNA for mouse interferon-beta
    Y Higashi
    J Biol Chem 258:9522-9. 1983
    ..The cDNA, when fused to a SV40 promoter sequence and then introduced into COS-7 cells, directed the synthesis and secretion of a protein product indistinguishable from the authentic mouse interferon-beta...
  92. pmc Functional switching of macrophage responses to tumor necrosis factor-alpha (TNF alpha) by interferons. Implications for the pleiotropic activities of TNF alpha
    F R Lake
    Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206
    J Clin Invest 93:1661-9. 1994
    ....
  93. ncbi Interferon-alpha/beta can impede development of carcinogen-induced squamous-cell tumors in the esophagus of C57B1 mice
    J Fagerberg
    Department of Oncology Radiumhemmet, Karolinska Hospital, Stockholm, Sweden
    Int J Cancer 62:103-6. 1995
    ..Treatment with interferon after the administration of the carcinogen was terminated had no effect on the appearance of tumors. These data suggest that interferon therapy can exert certain effects on carcinogenesis...
  94. pmc The high mobility group protein HMG I(Y) can stimulate or inhibit DNA binding of distinct transcription factor ATF-2 isoforms
    W Du
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138
    Proc Natl Acad Sci U S A 91:11318-22. 1994
    ..stimulates the binding of a specific isoform of the activating transcription factor 2 (ATF-2(195)) to the interferon beta (IFN-beta) gene promoter...
  95. ncbi Cross talk between interferon-gamma and -alpha/beta signaling components in caveolar membrane domains
    A Takaoka
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Science 288:2357-60. 2000
    ..This aspect of signaling cross talk by IFNs may apply to other cytokines...
  96. ncbi Activating immunity in the liver. II. IFN-beta attenuates NK cell-dependent liver injury triggered by liver NKT cell activation
    Zlatko Trobonjaca
    Department of Physiology and Immunology, Medical Faculty, University of Rijeka, Rijeka, Croatia
    J Immunol 168:3763-70. 2002
    ..This study identifies interacting subsets of the hepatic innate immune system (and cytokines that up- and down-regulate these interactions) activated early in immune-mediated liver pathology...
  97. ncbi Regulation of receptor activator of NF-kappa B ligand-induced osteoclastogenesis by endogenous interferon-beta (INF-beta ) and suppressors of cytokine signaling (SOCS). The possible counteracting role of SOCSs- in IFN-beta-inhibited osteoclast formation
    Toshikichi Hayashi
    Department of Oral Anatomy, Meikai University School of Dentistry, Sakado, Saitama 350 0283, Japan
    J Biol Chem 277:27880-6. 2002
    ..Thus, although the inhibitory cytokine such as IFN-beta is produced in response to RANKL, the inhibition of osteoclastogenesis may be rescued by the induction of signaling suppressors such as SOCSs...
  98. pmc Transcription factor YY1 binds to the murine beta interferon promoter and regulates its transcriptional capacity with a dual activator/repressor role
    Laure Weill
    Régulation de la Transcription et Maladies Génétiques, CNRS UPR2228, UFR Biomedicale, 75270 Paris Cedex 06, France
    J Virol 77:2903-14. 2003
    ..We conclude that YY1 has a dual activator/repressor role on IFN-beta promoter activity depending on its binding site and time after infection...
  99. pmc Specific engagement of TLR4 or TLR3 does not lead to IFN-beta-mediated innate signal amplification and STAT1 phosphorylation in resident murine alveolar macrophages
    Antonello Punturieri
    Pulmonary and Critical Care Medicine Section, and Research Service, Department of Veterans Affairs Medical Center, Ann Arbor, MI 48105, USA
    J Immunol 173:1033-42. 2004
    ....
  100. pmc Local therapy with CpG motifs in a murine model of allergic airway inflammation in IFN-beta knock-out mice
    Victor Matheu
    Section of Medical Inflammation Research, Department of Cell and Molecular Biology Lund University Sweden
    Respir Res 6:25. 2005
    ..Furthermore, type-I IFNs have been proposed to play a key role in mediating effects of CpG-ODN. The precise role of IFN-beta in the immunomodulatory effects of CpG-ODN is not known...
  101. ncbi Deficiency of type I interferon contributes to Sle2-associated component lupus phenotypes
    Jianwei Li
    University of Texas Southwestern Medical School, Dallas 75390 8884, USA
    Arthritis Rheum 52:3063-72. 2005
    ....

Research Grants11

  1. VIRUSES AND AUTOIMMUNE DISEASE
    Michael Oldstone; Fiscal Year: 2001
    ..The second order of business is to determine the role of "self" (islet-cell) antigens other than the initial triggering viral antigen in the pathogenetic process leading to and determine their role in IDDM. ..
  2. STUDIES OF A NEW MYELIN GENE THAT CAUSES CNS DISEASE
    Michael Oldstone; Fiscal Year: 2001
    ..Their studies in rodents combined with those of their collaborator, Dr. Martin, should begin to characterize the role played by MONP in neurologic disease. ..
  3. Pathogenesis Studies in Scrapie (TSE Diseases)
    Michael Oldstone; Fiscal Year: 2003
    ..This model should be useful to study pathophysiology of CWD as well as probing CWD strain differences. ..
  4. Viruses and Diabetes
    Michael Oldstone; Fiscal Year: 2005
    ....
  5. MEASLES VIRUS STUDIES IN A TRANSGENIC MODEL
    Michael Oldstone; Fiscal Year: 2007
    ..abstract_text> ..
  6. Aging Disease--Prion/Transgenic/Immunologic Studies
    Michael Oldstone; Fiscal Year: 2008
    ..Lastly, Jose Criado will continue his electrophysiology and behavioral studies on the normal function of PrP and on its aberrations during TSE disease. ..
  7. Arenavirus Receptor-Structure/Function Studies
    Michael B Oldstone; Fiscal Year: 2010
    ..These findings have relevance for biodefense of several viruses including LFV. ..
  8. Therapeutics to Prevent/Treat Lassa Fever Virus
    Michael B Oldstone; Fiscal Year: 2010
    ..We anticipate making a significant contribution to drug development to treat these BSL-4 agents. ..
  9. NATURAL KILLER CELL TRAFFICKING AND DELIVERY OF FUNCTION
    THAIS SALAZAR MATHER; Fiscal Year: 2002
    ..Information resulting from these studies will yield significant and novel information for developing anti-viral and anticancer treatment protocols. ..
  10. Innate immune evasion and/or antagonism by eastern equine encephalitis virus
    KATHERINE RYMAN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  11. Key Innate Mechanisms of Natural Killer Cell Trafficking
    THAIS SALAZAR MATHER; Fiscal Year: 2007
    ..The experiments will take advantage of mice genetically deficient in chemokine or chemokine receptors. ..